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David Frazer

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Bean T Chen; Jared L Cumpston; Vincent Castranova; Sherri Friend; Walter McKinney; Dale W Porter; Diane Schwegler-Berry; Samuel Stone; David G Frazer
Multi-walled carbon nanotubes: sampling criteria and aerosol characterization.
Ann F Hubbs; Mark C Jackson; Michael Kashon; Kathleen Kreiss; Diane Schwegler-Berry; Patsy A Willard; Lori A Battelli; Vincent Castranova; Amy M Cumpston; Jeffrey S Fedan; Kara L Fluharty; David G Frazer; Sherri Friend; William T Goldsmith; Madhusudan P Goravanahally; Krishnan Sriram
Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats.
Walter McKinney; Robert R Mercer; Jeffrey S Reynolds; T M Sager; T A Thomas; S Waugh; Bean T Chen; David G Frazer; M Jackson; C Johnson; Kristine Krajnak; Aliakbar A Afshari; Vincent Castranova
Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles.

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2012: Bean T Chen; Jared L Cumpston; Vincent Castranova; Sherri Friend; Walter McKinney; Dale W Porter; Diane Schwegler-Berry; Samuel Stone; David G Frazer
Multi-walled carbon nanotubes: sampling criteria and aerosol characterization.
Inhalation toxicology 2012;24(12):798-820.
2012: Ann F Hubbs; Mark C Jackson; Michael Kashon; Kathleen Kreiss; Diane Schwegler-Berry; Patsy A Willard; Lori A Battelli; Vincent Castranova; Amy M Cumpston; Jeffrey S Fedan; Kara L Fluharty; David G Frazer; Sherri Friend; William T Goldsmith; Madhusudan P Goravanahally; Krishnan Sriram
Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats.
The American journal of pathology 2012;181(3):829-44.
2012: Walter McKinney; Robert R Mercer; Jeffrey S Reynolds; T M Sager; T A Thomas; S Waugh; Bean T Chen; David G Frazer; M Jackson; C Johnson; Kristine Krajnak; Aliakbar A Afshari; Vincent Castranova
Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles.
Inhalation toxicology 2012;24(7):447-57.
2012: Aaron Erdely; David G Frazer; Ja K Gu; Tracy Hulderman; Michael Kashon; Shengqiao Li; Angie Liston; Rebecca Salmen-Muniz; Petia P Simeonova; Samuel Stone; James M Antonini; Bean T Chen; Patti C Zeidler-Erdely
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation.
Particle and fibre toxicology 2012;9():25.
2011: Ryan F LeBuf; Bean T Chen; David G Frazer; Aleksandr B Stefaniak; M Abbas Virji
Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments.
Nanotoxicology 2011;5(4):687-99.
2011: Aaron Erdely; Tracy Hulderman; Rebecca Salmen-Muniz; Angie Liston; Patti C Zeidler-Erdely; Bean T Chen; Samuel Stone; David G Frazer; James M Antonini; Petia P Simeonova
Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice.
Toxicology letters 2011;204(1):12-6.
2011: James M Antonini; Jenny R Roberts; Samuel Stone; Bean T Chen; Diane Schwegler-Berry; Rebecca Chapman; Patti C Zeidler-Erdely; Ronnee N Andrews; David G Frazer
Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats.
Archives of toxicology 2011;85(5):487-98.
2011: Patti C Zeidler-Erdely; Lori A Battelli; Sam Stone; Bean T Chen; David G Frazer; Shih-Houng Young; Aaron Erdely; Michael Kashon; Ronnee Andrews; James M Antonini
Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice.
Inhalation toxicology 2011;23(2):112-20.
2011: Krishnan Sriram; David G Frazer; William T Goldsmith; Mark Jackson; Amy M Jefferson; Gary X Lin; Walter McKinney; Victor A Robinson; Vincent Castranova
Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A.
Journal of toxicology and environmental health. Part A 2011;74(21):1405-18.
2011: Jenny R Roberts; Michael J Shimko; Janet A Thompson; Eric J Zaccone; Vincent Castranova; David G Frazer; William T Goldsmith; Mark Jackson; Michael Kashon; Allison Kenyon; Walter McKinney; Giovanni Piedimonte; Jeffrey S Reynolds; Jeffrey S Fedan
Pulmonary effects after acute inhalation of oil dispersant (COREXIT EC9500A) in rats.
Journal of toxicology and environmental health. Part A 2011;74(21):1381-96.
2011: David G Frazer; Jeffrey S Reynolds; Mark C Jackson
Determining when enhanced pause (Penh) is sensitive to changes in specific airway resistance.
Journal of toxicology and environmental health. Part A 2011;74(5):287-95.
2010: Bean T Chen; Aliakbar Afshari; Samuel Stone; Mark Jackson; Diane Schwegler-Berry; David G Frazer; Vincent Castranova; Treye A Thomas
Nanoparticles-containing spray can aerosol: characterization, exposure assessment, and generator design.
Inhalation toxicology 2010;22(13):1072-82.
2010: William T Goldsmith; A M Mahmoud; Jeffrey S Reynolds; Walter McKinney; Aliakbar A Afshari; A A Abaza; David G Frazer
A system for recording high fidelity cough sound and airflow characteristics.
Annals of biomedical engineering 2010;38(2):469-77.
2009: James M Antonini; Krishnan Sriram; Stanley A Benkovic; Jenny R Roberts; Samuel Stone; Bean T Chen; Diane Schwegler-Berry; Amy M Jefferson; Brenda K Billig; Christopher M Felton; Mary Ann Hammer; Fang Ma; David G Frazer; James P O'Callaghan; Diane B Miller
Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure.
Neurotoxicology 2009;30(6):915-25.
2009: James M Antonini; Jenny R Roberts; Sam Stone; Bean T Chen; Diane Schwegler-Berry; David G Frazer
Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats.
Inhalation toxicology 2009;21(3):182-92.
2009: Ayman A Abaza; Jeremy B Day; Jeffrey S Reynolds; Ahmed M Mahmoud; W Travis Goldsmith; Walter G McKinney; E Lee Petsonk; David G Frazer
Classification of voluntary cough sound and airflow patterns for detecting abnormal pulmonary function.
Cough (London, England) 2009;5():8.
2008: Jeffrey S Reynolds; Victor J Johnson; David G Frazer
Unrestrained acoustic plethysmograph for measuring specific airway resistance in mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;105(2):711-7.
2008: Ann F Hubbs; William T Goldsmith; Michael Kashon; David G Frazer; Robert R Mercer; Lori A Battelli; Gregory J Kullman; Diane Schwegler-Berry; Sherri Friend; Vincent Castranova
Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats.
Toxicologic pathology 2008;36(2):330-44.
2007: James M Antonini; Samuel Stone; Jenny R Roberts; Bean Chen; Diane Schwegler-Berry; Aliakbar A Afshari; David G Frazer
Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats.
Toxicology and applied pharmacology 2007;223(3):234-45.
2006: Jeffrey S Reynolds; David G Frazer
Unrestrained acoustic plethysmograph for measuring tidal volume in mice.
Annals of biomedical engineering 2006;34(9):1494-9.
2006: Linda J Huffman; Christopher M Beighley; David G Frazer; Walter McKinney; Dale W Porter
Increased susceptibility of the lungs of hyperthyroid rats to oxidant injury: specificity of effects.
Toxicology 2006;225(2-3):119-27.
2006: Brandon F Law; Samuel Stone; David G Frazer; Paul D Siegel
Characterization of laboratory simulated road paving-like asphalt by high-performance liquid chromatography and gas chromatography-mass spectrometry.
Journal of occupational and environmental hygiene 2006;3(7):343-50.
2006: James M Antonini; Aliakbar A Afshari; Samuel Stone; Bean Chen; Diane Schwegler-Berry; W Gary Fletcher; William T Goldsmith; Kurt H Vandestouwe; Walter McKinney; Vincent Castranova; David G Frazer
Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals.
Journal of occupational and environmental hygiene 2006;3(4):194-203; quiz D45.
2006: Linda J Huffman; Christopher M Beighley; David G Frazer; Walter McKinney; Dale W Porter
Increased susceptibility of hyperthyroid rats to ozone: early events and mechanisms.
Journal of toxicology and environmental health. Part A 2006;69(6):465-79.
2005: William G Lindsley; Steven Collicott; Gunter N Franz; Brian Stolarik; Walter McKinney; David G Frazer
Asymmetric and axisymmetric constant curvature liquid-gas interfaces in pulmonary airways.
Annals of biomedical engineering 2005;33(3):365-75.
2004: David G Frazer; William G Lindsley; Kimberly Rosenberry; Walter McKinney; William T Goldsmith; Jeffrey S Reynolds; Seth Tomblyn; Aliakbar A Afshari
Model predictions of the recruitment of lung units and the lung surface area-volume relationship during inflation.
Annals of biomedical engineering 2004;32(5):756-63.
2004: HW Zhao; Xuejun J Yin; David G Frazer; Mark W Barger; Paul D Siegel; Lyndell Millecchia; BZ Zhong; Seth Tomblyn; Samuel Stone; Joseph K H Ma; Vincent Castranova; Jane Y C Ma
Effects of paving asphalt fume exposure on genotoxic and mutagenic activities in the rat lung.
Mutation research 2004;557(2):137-49.
2004: Linda J Huffman; David G Frazer; DJ Prugh; K Brumbaugh; C Platania; Jeffrey S Reynolds; William T Goldsmith
Enhanced pulmonary inflammatory response to inhaled endotoxin in pregnant rats.
Journal of toxicology and environmental health. Part A 2004;67(2):125-44.
2003: Jin J Wang; William D Marshall; David G Frazer; Brandon Law; Daniel M Lewis
Characterization of DNA adducts from lung tissue of asphalt fume-exposed mice by nanoflow liquid chromatography quadrupole time-of-flight mass spectrometry.
Analytical biochemistry 2003;322(1):79-88.
2003: Jin J Wang; David G Frazer; Samuel Stone; Travis Goldsmith; Brandon Law; Amy Moseley; Janet Simpson; Aliakbar A Afshari; Daniel M Lewis
Urinary benzo[a]pyrene and its metabolites as molecular biomarkers of asphalt fume exposure characterized by microflow LC coupled to hybrid quadrupole time-of-flight mass spectrometry.
Analytical chemistry 2003;75(21):5953-60.
2003: James M Antonini; Jenny R Roberts; Michael D Taylor; Xuejun Yin; Samuel Stone; Amy Moseley; Joseph K H Ma; David G Frazer; Vincent Castranova; Jane Y C Ma
Effect of asphalt fume inhalation exposure at simulated road paving conditions prior to bacterial infection on lung defense responses in rats.
Inhalation toxicology 2003;15(13):1347-68.
2003: Jin J Wang; David G Frazer; Brandon Law; Daniel M Lewis
Identification and quantification of urinary benzo[a]pyrene and its metabolites from asphalt fume exposed mice by microflow LC coupled to hybrid quadrupole time-of-flight mass spectrometry.
The Analyst 2003;128(7):864-70.
2003: Jane Y C Ma; Appavoo Rengasamy; David G Frazer; Mark W Barger; Ann F Hubbs; Lori A Battelli; Seth Tomblyn; Samuel Stone; Vincent Castranova
Inhalation exposure of rats to asphalt fumes generated at paving temperatures alters pulmonary xenobiotic metabolism pathways without lung injury.
Environmental health perspectives 2003;111(9):1215-21.
2003: Erin R Sikora; Samuel Stone; Seth Tomblyn; David G Frazer; Vincent Castranova; Richard D Dey
Asphalt exposure enhances neuropeptide levels in sensory neurons projecting to the rat nasal epithelium.
Journal of toxicology and environmental health. Part A 2003;66(11):1015-27.
2003: Shih-Houng Young; Victor A Robinson; Mark W Barger; David G Frazer; Vincent Castranova; Robert R Jacobs
Partially opened triple helix is the biologically active conformation of 1-->3-beta-glucans that induces pulmonary inflammation in rats.
Journal of toxicology and environmental health. Part A 2003;66(6):551-63.
2003: Shih-Houng Young; Victor A Robinson; Mark W Barger; Michael Whitmer; Dale W Porter; David G Frazer; Vincent Castranova
Exposure to particulate 1-->3-beta-glucans induces greater pulmonary toxicity than soluble 1-->3-beta-glucans in rats.
Journal of toxicology and environmental health. Part A 2003;66(1):25-38.
2002: Jeffrey S Reynolds; Kimberly J Stemple; Raymond A Petsko; Thomas R Ebeling; David G Frazer
Nonlinear model for offline correction of pulmonary waveform generators.
IEEE transactions on bio-medical engineering 2002;49(12 Pt 2):1567-73.
2002: Ann F Hubbs; Lori A Battelli; William T Goldsmith; Dale W Porter; David G Frazer; S Friend; Diane Schwegler-Berry; Robert R Mercer; Jeffrey S Reynolds; Ardith Grote; Vincent Castranova; Greg Kullman; Jeffrey S Fedan; Janet Thompson; W G Jones
Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring.
Toxicology and applied pharmacology 2002;185(2):128-35.
2002: Anna A Shvedova; Elena R Kisin; Ashley Murray; Travis Goldsmith; Jeffrey S Reynolds; Vincent Castranova; David G Frazer; Choudari Kommineni
Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets.
Toxicology 2002;177(2-3):285-97.
2002: Shih-Houng Young; Victor A Robinson; Mark W Barger; Patti C Zeidler; Dale W Porter; David G Frazer; Vincent Castranova
Modified endotoxin responses in rats pretreated with 1-->3-beta-glucan (zymosan A).
Toxicology and applied pharmacology 2002;178(3):172-9.
2002: Vincent Castranova; David G Frazer; L K Manley; Richard D Dey
Pulmonary alterations associated with inhalation of occupational and environmental irritants.
International immunopharmacology 2002;2(2-3):163-72.
2001: Shih-Houng Young; Victor A Robinson; Mark W Barger; Dale W Porter; David G Frazer; Vincent Castranova
Acute inflammation and recovery in rats after intratracheal instillation of a 1-->3-beta-glucan (zymosan A).
Journal of toxicology and environmental health. Part A 2001;64(4):311-25.
2001: J Wang; Daniel M Lewis; Vincent Castranova; David G Frazer; Travis Goldsmith; Seth Tomblyn; J Simpson; Samuel Stone; Aliakbar A Afshari; Paul D Siegel
Characterization of asphalt fume composition under simulated road paving conditions by GC/MS and microflow LC/quadrupole time-of-flight MS.
Analytical chemistry 2001;73(15):3691-700.
2001: Zhong-Xin Wu; D F Maize; Brian E Satterfield; David G Frazer; Jeffrey S Fedan; Richard D Dey
Role of intrinsic airway neurons in ozone-induced airway hyperresponsiveness in ferret trachea.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(1):371-8.
2001: Shih-Houng Young; J Ye; David G Frazer; Xianglin Shi; Vincent Castranova
Molecular mechanism of tumor necrosis factor-alpha production in 1-->3-beta-glucan (zymosan)-activated macrophages.
The Journal of biological chemistry 2001;276(23):20781-7.
2001: Linda J Huffman; DJ Judy; K Brumbaugh; David G Frazer; Jeffrey S Reynolds; Walter McKinney; William T Goldsmith
Hyperthyroidism increases the risk of ozone-induced lung toxicity in rats.
Toxicology and applied pharmacology 2001;173(1):18-26.
2001: Ann F Hubbs; N S Minhas; William Jones; Mark Greskevitch; Lori A Battelli; Dale W Porter; William T Goldsmith; David G Frazer; Douglas Landsittel; Jane Y C Ma; Mark W Barger; K Hill; Diane Schwegler-Berry; Victor A Robinson; Vincent Castranova
Comparative pulmonary toxicity of 6 abrasive blasting agents.
Toxicological sciences : an official journal of the Society of Toxicology 2001;61(1):135-43.
2001: L Brancazio; Gunter N Franz; E L Petsonk; David G Frazer
Lung area--volume models in relation to the recruitment--derecruitment of individual lung units.
Annals of biomedical engineering 2001;29(3):252-62.
2000: Linda J Huffman; DJ Judy; K Murali Krishna Rao; David G Frazer; William T Goldsmith
Lung responses to hypothyroidism, hyperthyroidism, and lipopolysaccharide challenge in rats.
Journal of toxicology and environmental health. Part A 2000;61(7):623-39.
2000: Jeffrey S Fedan; Lyndell Millecchia; Richard A Johnston; Appavoo Rengasamy; Ann F Hubbs; Richard D Dey; L X Yuan; D Watson; William T Goldsmith; Jeffrey S Reynolds; L Orsini; Juanita _ Carnes; Deborah Cutler; David G Frazer
Effect of ozone treatment on airway reactivity and epithelium-derived relaxing factor in guinea pigs.
The Journal of pharmacology and experimental therapeutics 2000;293(3):724-34.
1999: W Cheng; D S DeLong; Gunter N Franz; E L Petsonk; David G Frazer
Discountinuous lung sounds and hysteresis in control and Tween 20-rinsed excised rat lungs.
Respiration physiology 1999;117(2-3):131-40.
1998: J Huang; Lyndell Millecchia; David G Frazer; Jeffrey S Fedan
Airway hyperreactivity elicited by toluene diisocyanate (TDI)-albumin conjugate is not accompanied by airway eosinophilic infiltration in guinea pigs.
Archives of toxicology 1998;72(3):141-6.
1997: J Huang; David G Frazer; Lyndell Millecchia; Jeffrey S Fedan
Brief exposure of air-filled guinea-pig isolated trachea to low levels of toluene diisocyanate (TDI) vapor in vitro increases reactivity to methacholine.
Toxicology 1997;124(2):83-93.
1997: T E Lawrence; Lyndell Millecchia; David G Frazer; Jeffrey S Fedan
Pulmonary dendritic cell distribution and prevalence in guinea pig airways: effect of ovalbumin sensitization and challenge.
The Journal of pharmacology and experimental therapeutics 1997;282(2):995-1004.
1997: Linda J Huffman; DJ Judy; David G Frazer; R E Shapiro; Vincent Castranova; M Billie; H V Dedhia
Inhalation of toluene diisocyanate is associated with increased production of nitric oxide by rat bronchoalveolar lavage cells.
Toxicology and applied pharmacology 1997;145(1):61-7.
1997: Ann F Hubbs; Vincent Castranova; Jane Y C Ma; David G Frazer; Paul D Siegel; B S Ducatman; Ardith Grote; Diane Schwegler-Berry; Victor A Robinson; C Van Dyke; Mark W Barger; J Xiang; J Parker
Acute lung injury induced by a commercial leather conditioner.
Toxicology and applied pharmacology 1997;143(1):37-46.
1995: Jeffrey S Fedan; T E Warner; L X Yuan; V a Robinson; David G Frazer
Nitric oxide synthase inhibitor and lipopolysaccharide effects on reactivity of guinea pig airways.
The Journal of pharmacology and experimental therapeutics 1995;272(3):1141-50.
1994: Jeffrey S Fedan; L X Yuan; J J Belt; David G Frazer
Polarized effects of amiloride and 4,4'-diisothiocyano-stilbene-2,2'-disulfonic acid on ATP-induced contraction of trachea.
European journal of pharmacology 1994;256(1):51-6.
1993: J A Smith; David G Frazer; Jeffrey S Fedan
Alteration in the modulatory role of respiratory epithelium after exposure of guinea pigs to respirable cotton dust.
The Journal of pharmacology and experimental therapeutics 1993;264(2):683-8.
1993: Jeffrey S Fedan; J J Belt; L X Yuan; David G Frazer
Relaxant effects of nucleotides in guinea pig isolated, perfused trachea: lack of involvement of prostanoids, Cl- channels and adenosine.
The Journal of pharmacology and experimental therapeutics 1993;264(1):217-20.
1993: Jeffrey S Fedan; J J Belt; L X Yuan; David G Frazer
Contractile effects of nucleotides in guinea pig isolated, perfused trachea: involvement of respiratory epithelium, prostanoids and Na+ and Cl- channels.
The Journal of pharmacology and experimental therapeutics 1993;264(1):210-6.
1992: Jeffrey S Fedan; David G Frazer
Influence of epithelium on the reactivity of guinea pig isolated, perfused trachea to bronchoactive drugs.
The Journal of pharmacology and experimental therapeutics 1992;262(2):741-50.
1990: Jeffrey S Fedan; M E Nutt; David G Frazer
Reactivity of guinea-pig isolated trachea to methacholine, histamine and isoproterenol applied serosally versus mucosally.
European journal of pharmacology 1990;190(3):337-45.
1985: Jeffrey S Fedan; David G Frazer; WJ Moorman; M D Attfield; M S Franczak; C J Kosten; J F Cahill; T R Lewis; F H Green
Effects of a two-year inhalation exposure of rats to coal dust and/or diesel exhaust on tension responses of isolated airway smooth muscle.
The American review of respiratory disease 1985;131(4):651-5.