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William Frazier

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David R Soto-Pantoja; William A Frazier; Thomas W Miller; David D Roberts
Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies.
Elfaridah P Frazier; Jeff S Isenberg; Sruti Shiva; Lei Zhao; Paul Schlesinger; Julie Dimitry; Mones S Abu-Asab; Maria Tsokos; David D Roberts; William A Frazier
Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.
Jeff S Isenberg; Yan Qin; Justin B Maxhimer; John M Sipes; Daryl Despres; Jurgen Schnermann; William A Frazier; David D Roberts
Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress.

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All Publications

2012: David R Soto-Pantoja; William A Frazier; Thomas W Miller; David D Roberts
Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):E2842; author reply E2844-5.
2011: Elfaridah P Frazier; Jeff S Isenberg; Sruti Shiva; Lei Zhao; Paul Schlesinger; Julie Dimitry; Mones S Abu-Asab; Maria Tsokos; David D Roberts; William A Frazier
Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.
Matrix biology : journal of the International Society for Matrix Biology 2011;30(2):154-61.
2009: Jeff S Isenberg; Yan Qin; Justin B Maxhimer; John M Sipes; Daryl Despres; Jurgen Schnermann; William A Frazier; David D Roberts
Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(2):110-9.
2009: Jeff S Isenberg; Douglas S Annis; Michael L Pendrak; Malgorzata Ptaszynska; William A Frazier; Deane F Mosher; David D Roberts
Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.
The Journal of biological chemistry 2009;284(2):1116-25.
2008: Jeff S Isenberg; William A Frazier; Murali K Cherukuri; David A Wink; David D Roberts
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.
Current drug targets 2008;9(10):833-41.
2008: Jeff S Isenberg; Martin J Romeo; Justin B Maxhimer; Jeremy Smedley; William A Frazier; David D Roberts
Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model: implications for human disease.
Annals of surgery 2008;247(5):860-8.
2008: Jeff S Isenberg; David D Roberts; William A Frazier
CD47: a new target in cardiovascular therapy.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(4):615-21.
2008: Jeff S Isenberg; William A Frazier; David D Roberts
Thrombospondin-1: a physiological regulator of nitric oxide signaling.
Cellular and molecular life sciences : CMLS 2008;65(5):728-42.
2008: Jeff S Isenberg; Martin J Romeo; Christine Yu; Christine K Yu; Khauh Nghiem; Jude Monsale; Margaret E Rick; David A Wink; William A Frazier; David D Roberts
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.
Blood 2008;111(2):613-23.
2008: Jeff S Isenberg; Loretta K Pappan; Martin J Romeo; Mones Abu-Asab; Maria Tsokos; David A Wink; William A Frazier; David D Roberts
Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts.
Annals of surgery 2008;247(1):180-90.
2007: Jeff S Isenberg; Fuminori Hyodo; Loretta K Pappan; Mones Abu-Asab; Maria Tsokos; Murali K Cherukuri; William A Frazier; David D Roberts
Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(12):2582-8.
2007: Jeff S Isenberg; Martin J Romeo; Mones Abu-Asab; Maria Tsokos; Anna Oldenborg; Loretta K Pappan; David A Wink; William A Frazier; David D Roberts
Increasing survival of ischemic tissue by targeting CD47.
Circulation research 2007;100(5):712-20.
2006: Jeff S Isenberg; Lisa A Ridnour; Julie Dimitry; William A Frazier; David A Wink; David D Roberts
CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1.
The Journal of biological chemistry 2006;281(36):26069-80.
2006: Sven Hagnerud; Partha Pratim Manna; Marina Cella; Asa Stenberg; William A Frazier; Marco COLONna; Per-Arne Oldenborg
Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):5772-8.
2005: Partha Pratim Manna; Julie Dimitry; Per-Arne Oldenborg; William A Frazier
CD47 augments Fas/CD95-mediated apoptosis.
The Journal of biological chemistry 2005;280(33):29637-44.
2005: Mattias Olsson; Pierre Bruhns; William A Frazier; Jeffrey V Ravetch; Per-Arne Oldenborg
Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia.
Blood 2005;105(9):3577-82.
2005: Jeff S Isenberg; Maria J Calzada; Longen Zhou; Nenghua Guo; Jack Lawler; Xue-Qing Wang; William A Frazier; David D Roberts
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(2):110-23.
2004: John F McDonald; Alex Zheleznyak; William A Frazier
Cholesterol-independent interactions with CD47 enhance alphavbeta3 avidity.
The Journal of biological chemistry 2004;279(17):17301-11.
2004: Partha Pratim Manna; William A Frazier
CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.
Cancer research 2004;64(3):1026-36.
2003: J F McDonald; Julie Dimitry; William A Frazier
An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs.
Biochemistry 2003;42(33):10001-11.
2003: Partha Pratim Manna; William A Frazier
The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3544-53.
2000: X Han; H Sterling; Yibang Chen; C Saginario; Eric J Brown; William A Frazier; FP Lindberg; Agnès Vignery
CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation.
The Journal of biological chemistry 2000;275(48):37984-92.
2000: Nader Sheibani; Christine M Sorenson; William A Frazier
Differential modulation of cadherin-mediated cell-cell adhesion by platelet endothelial cell adhesion molecule-1 isoforms through activation of extracellular regulated kinases.
Molecular biology of the cell 2000;11(8):2793-802.
2000: Eugene A Podrez; Maria Febbraio; Nader Sheibani; Dave Schmitt; Roy L Silverstein; David P Hajjar; P A Cohen; William A Frazier; Henry F Hoff; Stanley L Hazen
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species.
The Journal of clinical investigation 2000;105(8):1095-108.
2000: Nader Sheibani; Christine M Sorenson; L A Cornelius; William A Frazier
Thrombospondin-1, a natural inhibitor of angiogenesis, is present in vitreous and aqueous humor and is modulated by hyperglycemia.
Biochemical and biophysical research communications 2000;267(1):257-61.
1999: XQ Wang; FP Lindberg; William A Frazier
Integrin-associated protein stimulates alpha2beta1-dependent chemotaxis via Gi-mediated inhibition of adenylate cyclase and extracellular-regulated kinases.
The Journal of cell biology 1999;147(2):389-400.
1999: JM Green; A Zhelesnyak; Jun Chung; FP Lindberg; Marika Sarfati; William A Frazier; Eric J Brown
Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins.
The Journal of cell biology 1999;146(3):673-82.
1999: Jun Chung; XQ Wang; FP Lindberg; William A Frazier
Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation.
Blood 1999;94(2):642-8.
1999: William A Frazier; A G Gao; Julie Dimitry; Jun Chung; Eric J Brown; FP Lindberg; Maurine E Linder
The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi.
The Journal of biological chemistry 1999;274(13):8554-60.
1999: Nader Sheibani; William A Frazier
Thrombospondin-1, PECAM-1, and regulation of angiogenesis.
Histology and histopathology 1999;14(1):285-94.
1999: Nader Sheibani; Christine M Sorenson; William A Frazier
Tissue specific expression of alternatively spliced murine PECAM-1 isoforms.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;214(1):44-54.
1998: Nader Sheibani; William A Frazier
Direct use of synthetic peptides for antiserum production.
BioTechniques 1998;25(1):28-30, 32.
1998: XQ Wang; William A Frazier
The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells.
Molecular biology of the cell 1998;9(4):865-74.
1998: Nader Sheibani; William A Frazier
Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype.
Molecular biology of the cell 1998;9(4):701-13.
1997: DW Dawson; SF Pearce; R Zhong; Roy L Silverstein; William A Frazier; Noel P Bouck
CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells.
The Journal of cell biology 1997;138(3):707-17.
1997: Nader Sheibani; William A Frazier
Miniprep DNA isolation for automated sequencing of multiple samples.
Analytical biochemistry 1997;250(1):117-9.
1997: Nader Sheibani; P J Newman; William A Frazier
Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis.
Molecular biology of the cell 1997;8(7):1329-41.
1997: Jun Chung; A G Gao; William A Frazier
Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.
The Journal of biological chemistry 1997;272(23):14740-6.
1996: Nader Sheibani; William A Frazier
Repression of thrombospondin-1 expression, a natural inhibitor of angiogenesis, in polyoma middle T transformed NIH3T3 cells.
Cancer letters 1996;107(1):45-52.
1996: A G Gao; FP Lindberg; J M Dimitry; Eric J Brown; William A Frazier
Thrombospondin modulates alpha v beta 3 function through integrin-associated protein.
The Journal of cell biology 1996;135(2):533-44.
1996: A G Gao; FP Lindberg; M B Finn; Scott D Blystone; Eric J Brown; William A Frazier
Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.
The Journal of biological chemistry 1996;271(1):21-4.
1995: M F DeFreitas; C K Yoshida; William A Frazier; D L Mendrick; Robert Kypta; Louis F Reichardt
Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth.
Neuron 1995;15(2):333-43.
1995: Nader Sheibani; William A Frazier
Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6788-92.
1994: A G Gao; William A Frazier
Identification of a receptor candidate for the carboxyl-terminal cell binding domain of thrombospondins.
The Journal of biological chemistry 1994;269(47):29650-7.
1993: M D Kosfeld; William A Frazier
Identification of a new cell adhesion motif in two homologous peptides from the COOH-terminal cell binding domain of human thrombospondin.
The Journal of biological chemistry 1993;268(12):8808-14.
1992: M D Kosfeld; William A Frazier
Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1.
The Journal of biological chemistry 1992;267(23):16230-6.
1991: M D Kosfeld; T V Pavlopoulos; William A Frazier
Cell attachment activity of the carboxyl-terminal domain of human thrombospondin expressed in Escherichia coli.
The Journal of biological chemistry 1991;266(36):24257-9.
1991: C A Prater; J Plotkin; D Jaye; William A Frazier
The properdin-like type I repeats of human thrombospondin contain a cell attachment site.
The Journal of cell biology 1991;112(5):1031-40.