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John Freedman

Research Profile

Anatomy

Blood Platelets

Physiology

Platelet Activation

Procedures

Living Beings

Disorders

Idiopathic Thrombocytopenic Purpura

Chemicals & Drugs

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Publications

TOP 3
Armen V Gyulkhandanyan; John Freedman; Asuman Mutlu; Valery Leytin
Selective triggering of platelet apoptosis, platelet activation or both.
Asuman Mutlu; John Freedman; Armen V Gyulkhandanyan; Valery Leytin
Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimetic ABT-737 and calcium ionophore A23187: caspase-8 is activated via bypass of the death receptors.
Michael Blankstein; Robert Byrick; John Freedman; M B Garvey; Masaki Nakane; Annie K W Bang; Radovan Zdero; Emil H Schemitsch
A preliminary study of platelet activation after embolization of marrow contents.

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All Publications

2013: Armen V Gyulkhandanyan; John Freedman; Asuman Mutlu; Valery Leytin
Selective triggering of platelet apoptosis, platelet activation or both.
British journal of haematology 2013;161(2):245-54.
2012: Asuman Mutlu; John Freedman; Armen V Gyulkhandanyan; Valery Leytin
Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimetic ABT-737 and calcium ionophore A23187: caspase-8 is activated via bypass of the death receptors.
British journal of haematology 2012;159(5):565-71.
2012: Michael Blankstein; Robert Byrick; John Freedman; M B Garvey; Masaki Nakane; Annie K W Bang; Radovan Zdero; Emil H Schemitsch
A preliminary study of platelet activation after embolization of marrow contents.
Journal of orthopaedic trauma 2012;26(11):e214-20.
2012: Rukhsana Aslam; John Freedman; Simon Gebremeskel; Li Guo; Yu Hu; Michael Kim; Heyu Ni; George B Segel; Edwin R Speck; John W Semple
Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia.
Blood 2012;120(10):2127-32.
2012: Armen V Gyulkhandanyan; John Freedman; Asuman Mutlu; Valery Leytin
Markers of platelet apoptosis: methodology and applications.
Journal of thrombosis and thrombolysis 2012;33(4):397-411.
2012: Katerina Pavenski; John Freedman; J W Semple
HLA alloimmunization against platelet transfusions: pathophysiology, significance, prevention and management.
Tissue antigens 2012;79(4):237-45.
2010: Davor Brinc; Hoang Le-Tien; Andrew R Crow; John W Semple; John Freedman; Alan H Lazarus
Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model.
Transfusion 2010;50(9):2016-25.
2010: Margaret L Rand; Hong Wang; K W Annie Bang; Jerome M Teitel; Victor S Blanchette; John Freedman; Alan T Nurden
Phosphatidylserine exposure and other apoptotic-like events in Bernard-Soulier syndrome platelets.
American journal of hematology 2010;85(8):584-92.
2010: Adam M Gwozdz; Roland Leung; Hong Wang; K W A Bang; Marian A Packham; John Freedman; Margaret L Rand
Calpain inhibition by calpeptin does not prevent APLT activity reduction in PS-exposing platelets, but calpeptin has independent pro-apoptotic effects.
Thrombosis and haemostasis 2010;103(6):1218-27.
2010: John W Semple; John Freedman
Platelets and innate immunity.
Cellular and molecular life sciences : CMLS 2010;67(4):499-511.
2010: Michael Blankstein; Robert Byrick; Masaki Nakane; K W Annie Bang; John Freedman; Robin R Richards; Osamu Kajikawa; Rad Zdero; David Bell; Hans Kreder
Amplified inflammatory response to sequential hemorrhage, resuscitation, and pulmonary fat embolism: an animal study.
The Journal of bone and joint surgery. American volume 2010;92(1):149-61.
2010: Nadine Shehata; Valerie A Palda; Ralph M Meyer; Tom D Blydt-Hansen; Patricia Campbell; Carl Cardella; Steven Martin; Peter Nickerson; Kevork M Peltekian; Heather Ross; Tom K Waddell; Lori West; David Anderson; John Freedman; Heather Hume
The use of immunoglobulin therapy for patients undergoing solid organ transplantation: an evidence-based practice guideline.
Transfusion medicine reviews 2010;24 Suppl 1():S7-S27.
2009: Valery Leytin; Asuman Mutlu; Sergiy Mykhaylov; David J Allen; Armen V Gyulkhandanyan; John Freedman
The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.
Haematologica 2009;94(12):1783-4.
2009: Nadine Shehata; Alan Tinmouth; Gary Naglie; John Freedman; Kumanan Wilson
ABO-identical versus nonidentical platelet transfusion: a systematic review.
Transfusion 2009;49(11):2442-53.
2009: Hong Yang; Sean Lang; Zhimin Zhai; Ling Li; Walter H A Kahr; Pingguo Chen; Jelena Brkić; Christopher M Spring; Matthew J Flick; Jay L Degen; John Freedman; Heyu Ni
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.
Blood 2009;114(2):425-36.
2009: Valery Leytin; David J Allen; Asuman Mutlu; Sergiy Mykhaylov; Elena Lyubimov; John Freedman
Stored platelet concentrates produced by the platelet-rich plasma method are more resistant to apoptosis but more sensitive to activation than are platelets prepared by the buffy-coat and apheresis methods.
Transfusion 2009;49(7):1493-4.
2009: Valery Leytin; David J Allen; Asuman Mutlu; Armen V Gyulkhandanyan; Sergiy Mykhaylov; John Freedman
Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore.
Laboratory investigation; a journal of technical methods and pathology 2009;89(4):374-84.
2009: Adili Reheman; Hong Yang; Guangheng Zhu; Wuxun Jin; Feng He; Christopher M Spring; Xufang Bai; Peter L Gross; John Freedman; Heyu Ni
Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor.
Blood 2009;113(8):1809-17.
2008: Davor Brinc; Hoang Le-Tien; Andrew R Crow; Vinayakumar Siragam; John Freedman; Alan H Lazarus
Transfusion of IgG-opsonized foreign red blood cells mediates reduction of antigen-specific B cell priming in a murine model.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):948-53.
2008: Valery Leytin; David J Allen; Asuman Mutlu; Sergiy Mykhaylov; Elena V Lyubimov; John Freedman
Platelet activation and apoptosis are different phenomena: evidence from the sequential dynamics and the magnitude of responses during platelet storage.
British journal of haematology 2008;142(3):494-7.
2008: Frederick A Ofosu; John Freedman; John W Semple
Plasma-derived biological medicines used to promote haemostasis.
Thrombosis and haemostasis 2008;99(5):851-62.
2008: Davor Brinc; Hoang Le-Tien; Andrew R Crow; Vinayakumar Siragam; John Freedman; Alan H Lazarus
Immunoglobulin G-mediated regulation of the murine immune response to transfused red blood cells occurs in the absence of active immune suppression: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the fetus and newborn?
Immunology 2008;124(1):141-6.
2008: A Mutlu; David J Allen; John Freedman; Valery Leytin
The level of matrix metalloproteinase-2 in donor plasma strongly correlates with post-transfusion recovery of stored platelet concentrates.
Vox sanguinis 2008;94(2):143-5.
2008: John Freedman; Katherine Luke; Michael Escobar; Lee Vernich; Jo Anne Chiavetta
Experience of a network of transfusion coordinators for blood conservation (Ontario Transfusion Coordinators [ONTraC]).
Transfusion 2008;48(2):237-50.
2007: Rukhsana Aslam; Michael Kim; Edwin R Speck; Arjuna Contram Seetanah; Steven Molinski; John Freedman; John W Semple
Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells.
Transfusion 2007;47(11):2161-8.
2007: Davor Brinc; Hoang Le-Tien; Andrew R Crow; John Freedman; Alan H Lazarus
IgG-mediated immunosuppression is not dependent on erythrocyte clearance or immunological evasion: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the newborn?
British journal of haematology 2007;139(2):275-9.
2007: Mimi Kjaersgaard; Rukhsana Aslam; Michael Kim; Edwin R Speck; John Freedman; Donald I H Stewart; Erik J Wiersma; John W Semple
Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets.
Blood 2007;110(4):1359-61.
2007: Margaret L Rand; Hong Wang; K W A Bang; Marian A Packham; John Freedman
Persistence of phosphatidylserine exposure on activated platelets in vivo in rabbits.
Thrombosis and haemostasis 2007;98(2):477-8.
2007: John W Semple; Rukhsana Aslam; Michael Kim; Edwin R Speck; John Freedman
Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets.
Blood 2007;109(11):4803-5.
2007: Valery Leytin; David J Allen; Elena V Lyubimov; John Freedman
Higher thrombin concentrations are required to induce platelet apoptosis than to induce platelet activation.
British journal of haematology 2007;136(5):762-4.
2007: R Leung; A M Gwozdz; Hong Wang; K W A Bang; Marian A Packham; John Freedman; Margaret L Rand
Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity.
Journal of thrombosis and haemostasis : JTH 2007;5(3):560-70.
2007: Markus Schmugge; K W A Bang; Victor S Blanchette; Manuela Albisetti; Bairbre L Connolly; John Freedman; Margaret L Rand
Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines.
Acta haematologica 2007;117(3):145-8.
2007: Andrew R Crow; Seng Song; John W Semple; John Freedman; Alan H Lazarus
A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?
Blood 2007;109(1):155-8.
2006: Valery Leytin; David J Allen; Sergiy Mykhaylov; Elena V Lyubimov; John Freedman
Thrombin-triggered platelet apoptosis.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2656-63.
2006: H Yang; A Reheman; Pingguo Chen; G Zhu; R O Hynes; John Freedman; D D Wagner; Heyu Ni
Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo.
Journal of thrombosis and haemostasis : JTH 2006;4(10):2230-7.
2006: Michelle Lee Webster; Ebrahim Sayeh; Min Crow; Pingguo Chen; Bernhard Nieswandt; John Freedman; Heyu Ni
Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies.
Blood 2006;108(3):943-6.
2006: Margaret L Rand; Hong Wang; K W A Bang; Marian A Packham; John Freedman
Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits.
Journal of thrombosis and haemostasis : JTH 2006;4(7):1621-3.
2006: Vinayakumar Siragam; Andrew R Crow; Davor Brinc; Seng Song; John Freedman; Alan H Lazarus
Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells.
Nature medicine 2006;12(6):688-92.
2006: Valery Leytin; Sergiy Mykhaylov; Alison F Starkey; David J Allen; Herbert Lau; Heyu Ni; John W Semple; Alan H Lazarus; John Freedman
Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia.
British journal of haematology 2006;133(1):78-82.
2006: Heyu Ni; Pingguo Chen; Christopher M Spring; Ebrahim Sayeh; John W Semple; Alan H Lazarus; Richard O Hynes; John Freedman
A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.
Blood 2006;107(7):2976-83.
2006: Rukhsana Aslam; Edwin R Speck; Michael Kim; Andrew R Crow; K W A Bang; Frederick Nestel; Heyu Ni; Alan H Lazarus; John Freedman; John W Semple
Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo.
Blood 2006;107(2):637-41.
2005: John Freedman; K Luke; Neerav Monga; S Lincoln; R Koen; M Escobar; Jo Anne Chiavetta
A provincial program of blood conservation: The Ontario Transfusion Coordinators (ONTraC).
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2005;33(3):343-9.
2005: John Freedman
Theme issue on Ontario initiatives in blood conservation and blood management.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2005;33(3):315-6.
2005: John W Semple; John Freedman
Autoimmune pathogenesis and autoimmune hemolytic anemia.
Seminars in hematology 2005;42(3):122-30.
2005: A Reheman; P Gross; H Yang; Pingguo Chen; D Allen; Valery Leytin; John Freedman; Heyu Ni
Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation.
Journal of thrombosis and haemostasis : JTH 2005;3(5):875-83.
2005: Seng Song; Andrew R Crow; Vinayakumar Siragam; John Freedman; Alan H Lazarus
Monoclonal antibodies that mimic the action of anti-D in the amelioration of murine ITP act by a mechanism distinct from that of IVIg.
Blood 2005;105(4):1546-8.
2005: Vinayakumar Siragam; Davor Brinc; Andrew R Crow; Seng Song; John Freedman; Alan H Lazarus
Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?
The Journal of clinical investigation 2005;115(1):155-60.
2004: Ebrahim Sayeh; Rukhsana Aslam; Edwin R Speck; Hoang Le-Tien; Alan H Lazarus; John Freedman; John W Semple
Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype.
Transfusion 2004;44(11):1572-8.
2004: Valery Leytin; David J Allen; Adam Gwozdz; Bernadette Garvey; John Freedman
Role of platelet surface glycoprotein Ibalpha and P-selectin in the clearance of transfused platelet concentrates.
Transfusion 2004;44(10):1487-95.
2004: John Freedman; M Bernadette Garvey
Immunoadsorption of factor VIII inhibitors.
Current opinion in hematology 2004;11(5):327-33.
2004: Valery Leytin; David J Allen; Sergiy Mykhaylov; Lukasz Mis; Elena V Lyubimov; Bernadette Garvey; John Freedman
Pathologic high shear stress induces apoptosis events in human platelets.
Biochemical and biophysical research communications 2004;320(2):303-10.
2004: Alan T Nurden; Christelle Breillat; Béatrice Jacquelin; Robert Combrié; John Freedman; Victor S Blanchette; Markus Schmugge; Margaret L Rand
Triple heterozygosity in the integrin alphaIIb subunit in a patient with Glanzmann's thrombasthenia.
Journal of thrombosis and haemostasis : JTH 2004;2(5):813-9.
2004: Margaret L Rand; Hong Wang; K W A Bang; K S V Poon; Marian A Packham; John Freedman
Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence.
Journal of thrombosis and haemostasis : JTH 2004;2(4):651-9.
2004: Ebrahim Sayeh; Katherine Sterling; Edwin R Speck; John Freedman; John W Semple
IgG antiplatelet immunity is dependent on an early innate natural killer cell-derived interferon-gamma response that is regulated by CD8+ T cells.
Blood 2004;103(7):2705-9.
2004: Markus Schmugge; M S Dunn; K S Amankwah; Victor S Blanchette; John Freedman; Margaret L Rand
The activity of the von Willebrand factor cleaving protease ADAMTS-13 in newborn infants.
Journal of thrombosis and haemostasis : JTH 2004;2(2):228-33.
2003: John Freedman
ITP: an overview of the conference and future directions with an abbreviated ITP history.
Journal of pediatric hematology/oncology 2003;25 Suppl 1():S77-84.
2003: John Freedman; Margaret L Rand; Olive Russell; Carole Davis; Patricia L Cheatley; Victor Blanchette; M Bernadette Garvey
Immunoadsorption may provide a cost-effective approach to management of patients with inhibitors to FVIII.
Transfusion 2003;43(11):1508-13.
2003: Malini D Coopamah; John Freedman; John W Semple
Anti-D initially stimulates an Fc-dependent leukocyte oxidative burst and subsequently suppresses erythrophagocytosis via interleukin-1 receptor antagonist.
Blood 2003;102(8):2862-7.
2003: Markus Schmugge; Margaret L Rand; K W A Bang; Meera Mody; Michael Stephen Dunn; Kofi Sarpong Amankwah; Victor S Blanchette; John Freedman
The relationship of von Willebrand factor binding to activated platelets from healthy neonates and adults.
Pediatric research 2003;54(4):474-9.
2003: Andrew R Crow; Seng Song; John Freedman; Cheryl D Helgason; R Keith Humphries; Katherine A Siminovitch; Alan H Lazarus
IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity.
Blood 2003;102(2):558-60.
2003: Valery Leytin; David J Allen; Bernadette Garvey; John Freedman
Extending storage of human platelets from 5 to 7 or 8 days does not significantly reduce their in vivo recovery and survival in a rabbit model.
Transfusion 2003;43(7):983-5.
2003: Valery Leytin; John Freedman
Platelet apoptosis in stored platelet concentrates and other models.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2003;28(3):285-95.
2003: Markus Schmugge; Margaret L Rand; John Freedman
Platelets and von Willebrand factor.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2003;28(3):269-77.
2003: Heyu Ni; John Freedman
Platelets in hemostasis and thrombosis: role of integrins and their ligands.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2003;28(3):257-64.
2003: Seng Song; Andrew R Crow; John Freedman; Alan H Lazarus
Monoclonal IgG can ameliorate immune thrombocytopenia in a murine model of ITP: an alternative to IVIG.
Blood 2003;101(9):3708-13.
2003: Qigui Yu; Jenny X Gu; Colin Kovacs; John Freedman; Elaine K Thomas; Mario A Ostrowski
Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8+ T cell memory responses in HIV-1-infected and HIV-1-uninfected individuals.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1797-805.
2003: Andrew R Crow; Seng Song; John W Semple; John Freedman; Alan H Lazarus
IVIG induces dose-dependent amelioration of ITP in rodent models.
Blood 2003;101(4):1658-9; author reply 1659.
2003: S Song; Meera Mody; John Freedman; J Ellis; Alan H Lazarus
von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function.
Journal of thrombosis and haemostasis : JTH 2003;1(2):337-46.
2003: Valery Leytin; David Mazer; Meera Mody; Bernadette Garvey; John Freedman
Hemolink, an o-raffinose cross-linked haemoglobin-based oxygen carrier, does not affect activation and function of human platelets in whole blood in vitro.
British journal of haematology 2003;120(3):535-41.
2003: Kumanan Wilson; Laura MacDougall; Brigitte Pinard; Mohammad A Amin; Dean Fergusson; Ian Graham; Morris A Blajchman; John Freedman; Doug Angus; Paul C Hébert
How should Canada fund the blood system? An evaluation of the chargeback proposal.
Hospital quarterly 2003;6(3):47-4.
2003: Malini D Coopamah; M Bernadette Garvey; John Freedman; John W Semple
Cellular immune mechanisms in autoimmune thrombocytopenic purpura: An update.
Transfusion medicine reviews 2003;17(1):69-80.
2002: Valery Leytin; Samantha Shakoor; Meera Mody; David Allen; Bernadette Garvey; John Freedman
Sepsis- and endotoxemia-generated cytokines do not trigger activation of human platelets.
Critical care medicine 2002;30(12):2771-3.
2002: John W Semple; John Freedman
Leukoreduction just doesn't "take away" immunogenic leukcocytes, it creates an immunosuppressive leukocyte dose.
Vox sanguinis 2002;83 Suppl 1():425-7.
2002: John W Semple; Michael Kim; Alan H Lazarus; John Freedman
Gamma-globulins prepared from sera of multiparous women bind anti-HLA antibodies and inhibit an established in vivo human alloimmune response.
Blood 2002;100(3):1055-9.
2002: John W Semple; John Freedman
Recipient antigen-processing pathways of allogeneic platelet antigens: essential mediators of immunity.
Transfusion 2002;42(7):958-61.
2002: Valery Leytin; David J Allen; Meera Mody; Margaret L Rand; Barbara Hannach; Bernadette Garvey; John Freedman
A rabbit model for monitoring in vivo viability of human platelet concentrates using flow cytometry.
Transfusion 2002;42(6):711-8.
2002: John W Semple; D Allen; M Rutherford; M Woloski; Michele David; Cindy D Wakefield; Sheila Butchart; John Freedman; Victor Blanchette
Anti-D (WinRho SD) treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production.
American journal of hematology 2002;69(3):225-7.
2002: John Freedman; Meera Mody; Alan H Lazarus; Lori Dewar; S Song; Victor S Blanchette; M Bernadette Garvey; Frederick A Ofosu
Platelet activation and hypercoagulability following treatment with porcine factor VIII (HYATE:C).
American journal of hematology 2002;69(3):192-9.
2002: Margaret L Rand; H Wang; Meera Mody; I Chu; I Treutiger; A Nguyen; Marian A Packham; John Freedman
Concurrent measurement of the survival of two populations of rabbit platelets labeled with either two PKH lipophilic dyes or two concentrations of biotin.
Cytometry 2002;47(2):111-7.
2001: Andrew R Crow; Seng Song; John W Semple; John Freedman; Alan H Lazarus
IVIg inhibits reticuloendothelial system function and ameliorates murine passive-immune thrombocytopenia independent of anti-idiotype reactivity.
British journal of haematology 2001;115(3):679-86.
2001: Mario A Ostrowski; J X Gu; Colin Kovacs; John Freedman; Mark A Luscher; Kelly S MacDonald
Quantitative and qualitative assessment of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cell immunity to gag in HIV-1-infected individuals with differential disease progression: reciprocal interferon-gamma and interleukin-10 responses.
The Journal of infectious diseases 2001;184(10):1268-78.
2001: Valery Leytin; S Shakoor; Meera Mody; D Allen; B Hannach; Bernadette Garvey; John Freedman
Interleukins 1beta, 6, 8 and tumour necrosis factor alpha do not induce platelet activation.
Transfusion medicine (Oxford, England) 2001;11(5):389-90.
2001: BA Cavic; John Freedman; Z Morel; Meera Mody; Margaret L Rand; D C Stone; Michael Thompson
Blood platelet adhesion to protein studied by on-line acoustic wave sensor.
The Analyst 2001;126(3):342-8.
2000: B J Patterson; John Freedman; Victor Blanchette; G Sher; Peter H Pinkerton; B Hannach; Jacinta Meharchand; W Lau; N Boyce; E Pinchefsky; T Tasev; J Pinchefsky; S Poon; L Shulman; P MacK; K Thomas; N Blanchette; D Greenspan; Tony Panzarella
Effect of premedication guidelines and leukoreduction on the rate of febrile nonhaemolytic platelet transfusion reactions.
Transfusion medicine (Oxford, England) 2000;10(3):199-206.
2000: Andrew R Crow; John Freedman; B Hannach; Alan H Lazarus
Monoclonal antibody-mediated inhibition of the human HLA alloimmune response to platelet transfusion is antigen specific and independent of Fcgamma receptor-mediated immune suppression.
British journal of haematology 2000;110(2):481-7.
2000: Valery Leytin; Meera Mody; John W Semple; Bernadette Garvey; John Freedman
Quantification of platelet activation status by analyzing P-selectin expression.
Biochemical and biophysical research communications 2000;273(2):565-70.
2000: P Mack; John Freedman
Autoimmune hemolytic anemia: a history.
Transfusion medicine reviews 2000;14(3):223-33.
2000: S Song; John Freedman; Meera Mody; Alan H Lazarus
Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets.
British journal of haematology 2000;109(4):851-6.
2000: Valery Leytin; Meera Mody; John W Semple; Bernadette Garvey; John Freedman
Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations.
Biochemical and biophysical research communications 2000;269(1):85-90.
2000: K W A Bang; Edwin R Speck; Victor S Blanchette; John Freedman; John W Semple
Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens.
Blood 2000;95(5):1735-42.
2000: Alan H Lazarus; J Ellis; John W Semple; Meera Mody; Andrew R Crow; John Freedman
Comparison of platelet immunity in patients with SLE and with ITP.
Transfusion science 2000;22(1-2):19-27.
1999: JF Wright; H Wang; A Hornstein; M Hogarth; Meera Mody; M Bernadette Garvey; Victor Blanchette; Gail Rock; John Freedman
Characterization of platelet glycoproteins and platelet/endothelial cell antibodies in patients with thrombotic thrombocytopenic purpura.
British journal of haematology 1999;107(3):546-55.
1999: S Song; John Freedman; Meera Mody; Alan H Lazarus
p38 MAPK is activated but not necessary in porcine von Willebrand factor-dependent platelet activation.
British journal of haematology 1999;107(3):532-8.
1999: Alan H Lazarus; Andrew R Crow; John Freedman; Victor Blanchette; B Hannach
Inhibition of a secondary human alloimmune response via the soluble active component of CD154 (CD40L) in severe combined immune-deficient mice engrafted with human lymphocytes.
Transfusion 1999;39(8):818-23.
1999: Meera Mody; Alan H Lazarus; John W Semple; John Freedman
Preanalytical requirements for flow cytometric evaluation of platelet activation: choice of anticoagulant.
Transfusion medicine (Oxford, England) 1999;9(2):147-54.
1999: Andrew R Crow; John Freedman; B Hannach; Victor Blanchette; Alan H Lazarus
Antibody-mediated inhibition of the human alloimmune response to platelet transfusion in Hu-PBL-SCID mice.
British journal of haematology 1999;104(4):919-24.
1999: John W Semple; Edwin R Speck; D Cosgrave; Alan H Lazarus; Victor S Blanchette; John Freedman
Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity.
Blood 1999;93(2):713-20.
1998: W K Chia; Victor Blanchette; Meera Mody; JF Wright; John Freedman
Characterization of HIV-1-specific antibodies and HIV-1-crossreactive antibodies to platelets in HIV-1-infected haemophiliac patients.
British journal of haematology 1998;103(4):1014-22.
1998: Frederick A Ofosu; John Freedman; Lori Dewar; Y Song; John W Fenton
A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation.
The Biochemical journal 1998;336 ( Pt 2)():283-5.
1998: A Schimmer; Meera Mody; M Sager; M Bernadette Garvey; M Hogarth; John Freedman
Platelet cold agglutinins: a flow cytometric analysis.
Transfusion science 1998;19(3):217-24.
1998: John Freedman; M Bernadette Garvey; G Elinder; Victor S Blanchette
Directions for research in autoimmune thrombocytopenic purpura (ITP).
Acta paediatrica (Oslo, Norway : 1992). Supplement 1998;424():82-4.
1998: BR Saxon; Meera Mody; Victor S Blanchette; John Freedman
Reticulated platelet counts in the assessment of thrombocytopenic disorders.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1998;424():65-70.
1998: John Freedman; M Blanchette
Idiopathic thrombocytopenic purpura (ITP): a historical odyssey.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1998;424():3-6.
1998: Manuel Carcao; Victor S Blanchette; JA Dean; L He; M A Kern; Ann Marie Stain; Cathy Sparling; Derek Stephens; G Ryan; John Freedman; Margaret L Rand
The Platelet Function Analyzer (PFA-100): a novel in-vitro system for evaluation of primary haemostasis in children.
British journal of haematology 1998;101(1):70-3.
1998: Hong Chang; Meera Mody; Alan H Lazarus; Frederick A Ofosu; M Bernadette Garvey; Victor Blanchette; Jerome M Teitel; John Freedman
Platelet activation induced by porcine factor VIII (Hyate:C).
American journal of hematology 1998;57(3):200-5.
1998: Victor Blanchette; John Freedman; B Garvey
Management of chronic immune thrombocytopenic purpura in children and adults.
Seminars in hematology 1998;35(1 Suppl 1):36-51.
1997: Pamela J Angle; P Thomas; B Chiu; John Freedman
Bronchiolitis obliterans with organizing pneumonia and cold agglutinin disease associated with phenytoin hypersensitivity syndrome.
Chest 1997;112(6):1697-9.
1997: Alan H Lazarus; Andrew R Crow; John W Semple; D Cosgrave; E J Kalovsky; B Hannach; Victor Blanchette; John Freedman
Induction of a secondary human anti-HLA alloimmune response in severe combined immunodeficient mice engrafted with human lymphocytes.
Transfusion 1997;37(11-12):1192-9.
1997: Elizabeth J Phillips; Clifford A Ottaway; John Freedman; M Kardish; J Li; W Singer; Ignatius W Fong
The effect of exercise on lymphocyte redistribution and leucocyte function in asymptomatic HIV-infected subjects.
Brain, behavior, and immunity 1997;11(3):217-27.
1997: John W Semple; K A Siminovitch; Meera Mody; Y Milev; Alan H Lazarus; JF Wright; John Freedman
Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure.
British journal of haematology 1997;97(4):747-54.
1997: L Liu; John Freedman; A Hornstein; John W Fenton; Y Song; Frederick A Ofosu
Binding of thrombin to the G-protein-linked receptor, and not to glycoprotein Ib, precedes thrombin-mediated platelet activation.
The Journal of biological chemistry 1997;272(3):1997-2004.
1997: T Kühne; John Freedman; John W Semple; J Doyle; Sheila Butchart; Victor S Blanchette
Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura.
The Journal of pediatrics 1997;130(1):17-24.
1996: Thomas Kühne; G Ryan; Victor Blanchette; John W Semple; A Hornstein; Meera Mody; W Chang; L McWhirter; John Freedman
Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants.
Pediatric research 1996;40(6):876-80.
1996: A Bang; E R Speck; Victor S Blanchette; John Freedman; John W Semple
Recipient humoral immunity against leukoreduced allogeneic platelets is suppressed by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase.
Blood 1996;88(8):2959-66.
1996: J F Wright; Victor S Blanchette; H Wang; N Arya; M Petric; John W Semple; W K Chia; John Freedman
Characterization of platelet-reactive antibodies in children with varicella-associated acute immune thrombocytopenic purpura (ITP).
British journal of haematology 1996;95(1):145-52.
1996: John W Semple; Y Milev; D Cosgrave; Meera Mody; A Hornstein; Victor Blanchette; John Freedman
Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity.
Blood 1996;87(10):4245-54.
1996: L Liu; John Freedman; A Hornstein; L Dewar; Morris A Blajchman; Frederick A Ofosu
Plasmin accelerates platelet-dependent prothrombinase formation without activating the platelets.
British journal of haematology 1996;92(2):458-65.
1995: Alan H Lazarus; J F Wright; Victor Blanchette; John Freedman
Analysis of platelets by flow cytometry.
Transfusion science 1995;16(4):353-61.
1995: J F Wright; Alan H Lazarus; John Freedman
Applications of flow cytometry in the analysis of blood leukocytes.
Transfusion science 1995;16(4):333-41.
1995: John W Semple; John Freedman
Abnormal cellular immune mechanisms associated with autoimmune thrombocytopenia.
Transfusion medicine reviews 1995;9(4):327-38.
1995: Thomas Kühne; A Hornstein; John W Semple; W Chang; Victor Blanchette; John Freedman
Flow cytometric evaluation of platelet activation in blood collected into EDTA vs. Diatube-H, a sodium citrate solution supplemented with theophylline, adenosine, and dipyridamole.
American journal of hematology 1995;50(1):40-5.
1995: John W Semple; E R Speck; Y P Milev; Victor Blanchette; John Freedman
Indirect allorecognition of platelets by T helper cells during platelet transfusions correlates with anti-major histocompatibility complex antibody and cytotoxic T lymphocyte formation.
Blood 1995;86(2):805-12.
1995: C David Mazer; A Hornstein; John Freedman
Platelet activation in warm and cold heart surgery.
The Annals of thoracic surgery 1995;59(6):1481-6.
1995: John Freedman; Alan H Lazarus
Applications of flow cytometry in transfusion medicine.
Transfusion medicine reviews 1995;9(2):87-109.
1995: W K Chia; John Freedman; X Li; I Salit; M Kardish; Stanley E Read
Programmed cell death induced by HIV type 1 antigen stimulation is associated with a decrease in cytotoxic T lymphocyte activity in advanced HIV type 1 infection.
AIDS research and human retroviruses 1995;11(2):249-56.
1994: L Liu; John Freedman; A Hornstein; John W Fenton; Frederick A Ofosu
Thrombin binding to platelets and their activation in plasma.
British journal of haematology 1994;88(3):592-600.
1993: J W Semple; D Allen; W Chang; P Castaldi; John Freedman
Rapid separation of CD4+ and CD19+ lymphocyte populations from human peripheral blood by a magnetic activated cell sorter (MACS).
Cytometry 1993;14(8):955-60.
1993: E Atlas; John Freedman; Victor Blanchette; M D Kazatchkine; John W Semple
Downregulation of the anti-HLA alloimmune response by variable region-reactive (anti-idiotypic) antibodies in leukemic patients transfused with platelet concentrates.
Blood 1993;81(2):538-42.
1992: John W Semple; John Freedman
Cellular immune mechanisms in chronic autoimmune thrombocytopenic purpura (ATP).
Autoimmunity 1992;13(4):311-9.
1991: John Freedman; A Hornstein
Simple method for differentiating between HLA and platelet-specific antibodies by flow cytometry.
American journal of hematology 1991;38(4):314-20.
1991: J W Semple; S Bruce; John Freedman
Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura.
American journal of hematology 1991;37(4):258-62.
1991: John Freedman; Victor Blanchette; A Hornstein; S Farkas; R Milner; M Adams; F C Lim; M Bernadette Garvey; B Hannach
White cell depletion of red cell and pooled random-donor platelet concentrates by filtration and residual lymphocyte subset analysis.
Transfusion 1991;31(5):433-40.
1990: A Keith Stewart; John Freedman; M Bernadette Garvey
Acute leukemia evolving from multiple myeloma and co-expressing myeloid and plasma cell antigens.
American journal of hematology 1990;34(3):210-4.
1989: John Freedman; A Gafni; M Bernadette Garvey; Victor Blanchette
A cost-effectiveness evaluation of platelet crossmatching and HLA matching in the management of alloimmunized thrombocytopenic patients.
Transfusion 1989;29(3):201-7.
1988: John Freedman; M Bernadette Garvey; Z Salomon de Friedberg; A Hornstein; Victor Blanchette
Random donor platelet crossmatching: comparison of four platelet antibody detection methods.
American journal of hematology 1988;28(1):1-7.
1988: R Shupak; Jerome M Teitel; M Bernadette Garvey; John Freedman
Intraarticular methylprednisolone therapy in hemophilic arthropathy.
American journal of hematology 1988;27(1):26-9.
1987: John Freedman; J Wright; F C Lim; M Bernadette Garvey
Hemolytic warm IgM autoagglutinins in autoimmune hemolytic anemia.
Transfusion 1987;27(6):464-7.
1987: John Freedman
The significance of complement on the red cell surface.
Transfusion medicine reviews 1987;1(1):58-70.
1987: John Freedman; R Mazaheri; S Read; M Bernadette Garvey; Jerome M Teitel
Humoral and cellular immune abnormalities in adult hemophiliacs followed over a 2-year period.
Diagnostic and clinical immunology 1987;5(1):30-40.