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Dolores Fregona

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Eszter Márta Nagy; Sergio Sitran; Laura Caparrotta; Monica Favaro; Luciano Marchiò; monica montopoli; Dolores Fregona
Zinc(II) complexes with dithiocarbamato derivatives: structural characterisation and biological assays on cancerous cell lines.
Morelle Negom Kouodom; Luca Ronconi; Sergio Sitran; Donatella Aldinucci; Giulia Boscutti; Marta Celegato; Marco Crisma; Fernando Formaggio; Dolores Fregona
Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy.
Eszter M Nagy; Andrea Pettenuzzo; Giulia Boscutti; Lisa Dalla Via; Luciano Marchiò; Dolores Fregona
Ruthenium(II/III)-based compounds with encouraging antiproliferative activity against non-small-cell lung cancer.

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All Publications

2012: Eszter Márta Nagy; Sergio Sitran; Laura Caparrotta; Monica Favaro; Luciano Marchiò; monica montopoli; Dolores Fregona
Zinc(II) complexes with dithiocarbamato derivatives: structural characterisation and biological assays on cancerous cell lines.
Journal of inorganic biochemistry 2012;117():131-9.
2012: Morelle Negom Kouodom; Luca Ronconi; Sergio Sitran; Donatella Aldinucci; Giulia Boscutti; Marta Celegato; Marco Crisma; Fernando Formaggio; Dolores Fregona
Rational design of gold(III)-dithiocarbamato peptidomimetics for the targeted anticancer chemotherapy.
Journal of inorganic biochemistry 2012;117():248-60.
2012: Eszter M Nagy; Andrea Pettenuzzo; Giulia Boscutti; Lisa Dalla Via; Luciano Marchiò; Dolores Fregona
Ruthenium(II/III)-based compounds with encouraging antiproliferative activity against non-small-cell lung cancer.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(45):14464-72.
2012: Eszter Márta Nagy; Chiara Nardon; Luca Ronconi; Dolores Fregona
Noble metal-dithiocarbamates precious allies in the fight against cancer.
Mini reviews in medicinal chemistry 2012;12(12):1216-29.
2012: Morelle Negom Kouodom; Luciano Marchiò; Chiara Nardon; Luca Ronconi; Donatella Aldinucci; Marta Celegato; Qingping Dou; Fernando Formaggio; Dolores Fregona
Toward the selective delivery of chemotherapeutics into tumor cells by targeting peptide transporters: tailored gold-based anticancer peptidomimetics.
Journal of medicinal chemistry 2012;55(5):2212-26.
2012: Lisa Dalla Via; Chiara Nardon; Dolores Fregona
Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer: a challenge for the future.
Future medicinal chemistry 2012;4(4):525-43.
2012: F Chiara; Dolores Fregona; A Gambalunga; A Nicolli; Andrea Rasola; Luca Ronconi; M Sciacovelli; Paolo Bernardi; Andrea Trevisan
Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death.
Cell death & disease 2012;3():e444.
2011: Eszter Márta Nagy; Chiara Nardon; Andrea Trevisan; Lorena Giovagnini; Luciano Marchiò; Dolores Fregona
Promising anticancer mono- and dinuclear ruthenium(III) dithiocarbamato complexes: systematic solution studies.
Dalton transactions (Cambridge, England : 2003) 2011;40(44):11885-95.
2011: Cristina Marzano; Luca Ronconi; Andrea Trevisan; Maria Cecilia Giron; Federica Chiara; Patrizia Cristofori; Ivo Faustinelli; Dolores Fregona
Gold(III)-dithiocarbamato anticancer agents: activity, toxicology and histopathological studies in rodents.
International journal of cancer. Journal international du cancer 2011;129(2):487-96.
2010: Eszter Marta Nagy; Lisa Dalla Via; Luca Ronconi; Dolores Fregona
Recent advances in PUVA photochemotherapy and PDT for the treatment of cancer.
Current pharmaceutical design 2010;16(16):1863-76.
2010: Luca Ronconi; Donatella Aldinucci; Qingping Dou; Dolores Fregona
Latest insights into the anticancer activity of gold(III)-dithiocarbamato complexes.
Anti-cancer agents in medicinal chemistry 2010;10(4):283-92.
2010: Xia Zhang; Michael Frezza; Vesna Milacic; Luca Ronconi; Yuhua Fan; Caifeng Bi; Dolores Fregona; Qingping Dou
Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes.
Journal of cellular biochemistry 2010;109(1):162-72.
2009: Luca Ronconi; Dolores Fregona
The Midas touch in cancer chemotherapy: from platinum- to gold-dithiocarbamato complexes.
Dalton transactions (Cambridge, England : 2003) 2009;(48):10670-80.
2009: Lorena Giovagnini; E Mancinetti; Luca Ronconi; Sergio Sitran; L Marchiò; I Castagliuolo; Paola Brun; Andrea Trevisan; Dolores Fregona
Preliminary chemico-biological studies on Ru(III) compounds with S-methyl pyrrolidine/dimethyl dithiocarbamate.
Journal of inorganic biochemistry 2009;103(5):774-82.
2008: Lorena Giovagnini; Sergio Sitran; Ignazio Castagliuolo; Paola Brun; Maddalena Corsini; Piero Zanello; Alfonso Zoleo; Annalisa Maniero; Barbara Biondi; Dolores Fregona
Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity.
Dalton transactions (Cambridge, England : 2003) 2008;(47):6699-708.
2008: Vesna Milacic; Di Chen; Lorena Giovagnini; Alejandro Diez; Dolores Fregona; Qingping Dou
Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity.
Toxicology and applied pharmacology 2008;231(1):24-33.
2008: Lorena Giovagnini; Sergio Sitran; monica montopoli; Laura Caparrotta; Maddalena Corsini; Claudia Rosani; Piero Zanello; Qingping Dou; Dolores Fregona
Chemical and biological profiles of novel copper(II) complexes containing S-donor ligands for the treatment of cancer.
Inorganic chemistry 2008;47(14):6336-43.
2008: Donatella Aldinucci; Lara Cattaruzza; Debora Lorenzon; Lorena Giovagnini; Dolores Fregona; Alfonso Colombatti
Antiproliferative and apoptotic effects of two new Pd(II) methylsarcosinedithiocarbamate derivatives on human acute myeloid leukemia cells in vitro.
Oncology research 2008;17(3):103-13.
2008: Vesna Milacic; Dolores Fregona; Qingping Dou
Gold complexes as prospective metal-based anticancer drugs.
Histology and histopathology 2008;23(1):101-8.
2007: Daniela Saggioro; Maria Pia Rigobello; Lucia Paloschi; Alessandra Folda; Stephen A Moggach; Simon Parsons; Luca Ronconi; Dolores Fregona; Alberto Bindoli
Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by thioredoxin redox system inhibition and activation of ERK pathway.
Chemistry & biology 2007;14(10):1128-39.
2007: Donatella Aldinucci; Debora Lorenzon; Luigi Stefani; Lorena Giovagnini; Alfonso Colombatti; Dolores Fregona
Antiproliferative and apoptotic effects of two new gold(III) methylsarcosinedithiocarbamate derivatives on human acute myeloid leukemia cells in vitro.
Anti-cancer drugs 2007;18(3):323-32.
2007: Patrizia Cristofori; Edoardo Zanetti; Dolores Fregona; Alessandro Piaia; Andrea Trevisan
Renal proximal tubule segment-specific nephrotoxicity: an overview on biomarkers and histopathology.
Toxicologic pathology 2007;35(2):270-5.
2006: Vesna Milacic; Di Chen; Luca Ronconi; Kristin R Landis-Piwowar; Dolores Fregona; Qingping Dou
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts.
Cancer research 2006;66(21):10478-86.
2006: Luca Ronconi; Cristina Marzano; Piero Zanello; Maddalena Corsini; Giorgia Miolo; Carlo Maccà; Andrea Trevisan; Dolores Fregona
Gold(III) dithiocarbamate derivatives for the treatment of cancer: solution chemistry, DNA binding, and hemolytic properties.
Journal of medicinal chemistry 2006;49(5):1648-57.
2005: Lorena Giovagnini; Cristina Marzano; Frazia Bettio; Dolores Fregona
Mixed complexes of Pt(II) and Pd(II) with ethylsarcosinedithiocarbamate and 2-/3-picoline as antitumor agents.
Journal of inorganic biochemistry 2005;99(11):2139-50.
2005: Luca Ronconi; Lorena Giovagnini; Cristina Marzano; Frazia Bettìo; Rodolfo Graziani; Giuseppe Pilloni; Dolores Fregona
Gold dithiocarbamate derivatives as potential antineoplastic agents: design, spectroscopic properties, and in vitro antitumor activity.
Inorganic chemistry 2005;44(6):1867-81.
2005: Lorena Giovagnini; Luca Ronconi; Donatella Aldinucci; Debora Lorenzon; Sergio Sitran; Dolores Fregona
Synthesis, characterization, and comparative in vitro cytotoxicity studies of platinum(II), palladium(II), and gold(III) methylsarcosinedithiocarbamate complexes.
Journal of medicinal chemistry 2005;48(5):1588-95.
2004: Andrea Trevisan; Matteo Borella Venturini; Livio Di Marco; Andrea Fabrello; Monica Giraldo; Edoardo Zanetti; Cristina Marzano; Dolores Fregona
Erythrocyte aminolevulinic acid dehydratase inhibition by cis-platin.
Toxicology letters 2004;152(2):105-10.
2004: Cristina Marzano; Frazia Bettio; Francarosa Baccichetti; Andrea Trevisan; Lorena Giovagnini; Dolores Fregona
Antitumor activity of a new platinum(II) complex with low nephrotoxicity and genotoxicity.
Chemico-biological interactions 2004;148(1-2):37-48.
2004: V Alverdi; Lorena Giovagnini; Cristina Marzano; Roberta Seraglia; Frazia Bettio; Sergio Sitran; Rodolfo Graziani; Dolores Fregona
Characterization studies and cytotoxicity assays of Pt(II) and Pd(II) dithiocarbamate complexes by means of FT-IR, NMR spectroscopy and mass spectrometry.
Journal of inorganic biochemistry 2004;98(6):1117-28.
2003: Dolores Fregona; Lorena Giovagnini; Luca Ronconi; Cristina Marzano; Andrea Trevisan; Sergio Sitran; B Biondi; Franco Bordin
Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate. Synthesis, chemical and biological characterization and in vitro nephrotoxicity.
Journal of inorganic biochemistry 2003;93(3-4):181-9.
2002: Cristina Marzano; Dolores Fregona; Francarosa Baccichetti; Andrea Trevisan; Lorena Giovagnini; Franco Bordin
Cytotoxicity and DNA damage induced by a new platinum(II) complex with pyridine and dithiocarbamate.
Chemico-biological interactions 2002;140(3):215-29.
2002: Luca Ronconi; Cristina Marzano; U Russo; Sergio Sitran; Rodolfo Graziani; Dolores Fregona
Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine.
Journal of inorganic biochemistry 2002;91(2):413-20.
2002: Cristina Marzano; Andrea Trevisan; Lorena Giovagnini; Dolores Fregona
Synthesis of a new platinum(II) complex: anticancer activity and nephrotoxicity in vitro.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(4):413-9.
2002: Andrea Trevisan; Cristina Marzano; Patrizia Cristofori; Matteo Borella Venturini; Lorena Giovagnini; Dolores Fregona
Synthesis of a palladium(II)-dithiocarbamate complex: biological assay and nephrotoxicity in rats.
Archives of toxicology 2002;76(5-6):262-8.
2001: G Faraglia; Dolores Fregona; Sergio Sitran; Lorena Giovagnini; Cristina Marzano; Francarosa Baccichetti; U Casellato; Rodolfo Graziani
Platinum(II) and palladium(II) complexes with dithiocarbamates and amines: synthesis, characterization and cell assay.
Journal of inorganic biochemistry 2001;83(1):31-40.