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Ernesto Freire

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Occupations

Procedures

Concepts & Ideas

Physiology

Protein Folding

Disorders

Protein Denaturation

Chemicals & Drugs

Phenomena

Living Beings

HIV-1

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Co-Publications
Name
14
Velazquez-Campoy, Adrian
13
Schön, Arne
13
Kiso, Yoshiaki
11
Luque, Irene
9
Hilser, Vincent
9
Sodroski, Joseph
8
Todd, MJ
7
Leavitt, Stephanie
7
Ohtaka, Hiroyasu
7
Amzel, Mario
6
Chaiken, Irwin
6
Nezami, Azin
6
Madani, Navid
6
Hidaka, Koushi
6
Kimura, Tooru

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Publications

TOP 3
Freire Ernesto
A thermodynamic approach to the affinity optimization of drug candidates.
Kassa Aemro; Madani Navid; Schön Arne; Haim Hillel; Finzi Andrés; Xiang Shi-Hua; Wang Liping; Princiotto Amy; Pancera Marie; Courter Joel; Smith Amos B; Freire Ernesto; Kwong Peter D; Sodroski Joseph
Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain.
Regnier Thomas; Sarma Diganta; Hidaka Koushi; Bacha Usman; Freire Ernesto; Hayashi Yoshio; Kiso Yoshiaki
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.

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All Publications

2009: Freire Ernesto
A thermodynamic approach to the affinity optimization of drug candidates.
Chemical biology & drug design 2009;74(5):468-72.
2009: Kassa Aemro; Madani Navid; Schön Arne; Haim Hillel; Finzi Andrés; Xiang Shi-Hua; Wang Liping; Princiotto Amy; Pancera Marie; Courter Joel; Smith Amos B; Freire Ernesto; Kwong Peter D; Sodroski Joseph
Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain.
Journal of virology 2009;83(17):8364-78.
2009: Regnier Thomas; Sarma Diganta; Hidaka Koushi; Bacha Usman; Freire Ernesto; Hayashi Yoshio; Kiso Yoshiaki
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(10):2722-7.
2009: Brower Evan T; Schön Arne; Klein Jeffrey C; Freire Ernesto
Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120.
Biochemistry 2009;48(4):779-85.
2009: Freire Ernesto; Schön Arne; Velazquez-Campoy Adrian
Isothermal titration calorimetry: general formalism using binding polynomials.
Methods in enzymology 2009;455():127-55.
2008: Hidaka Koushi; Kimura Tooru; Ruben Adam J; Uemura Tsuyoshi; Kamiya Mami; Kiso Aiko; Okamoto Tetsuya; Tsuchiya Yumi; Hayashi Yoshio; Freire Ernesto; Kiso Yoshiaki
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Bioorganic & medicinal chemistry 2008;16(23):10049-60.
2008: Madani Navid; Schön Arne; Princiotto Amy M; Lalonde Judith M; Courter Joel R; Soeta Takahiro; Ng Danny; Wang Liping; Brower Evan T; Xiang Shi-Hua; Kwon Young Do; Huang Chih-Chin; Wyatt Richard; Kwong Peter D; Freire Ernesto; Smith Amos B; Sodroski Joseph
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.
Structure (London, England : 1993) 2008;16(11):1689-701.
2008: Freire Ernesto
Do enthalpy and entropy distinguish first in class from best in class?
Drug discovery today 2008;13(19-20):869-74.
2008: Bacha Usman; Barrila Jennifer; Gabelli Sandra B; Kiso Yoshiaki; Mario Amzel L; Freire Ernesto
Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro).
Chemical biology & drug design 2008;72(1):34-49.
2008: Gopi Hosahudya; Umashankara M; Pirrone Vanessa; LaLonde Judith; Madani Navid; Tuzer Ferit; Baxter Sabine; Zentner Isaac; Cocklin Simon; Jawanda Navneet; Miller Shendra R; Schön Arne; Klein Jeffrey C; Freire Ernesto; Krebs Fred C; Smith Amos B; Sodroski Joseph; Chaiken Irwin
Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.
Journal of medicinal chemistry 2008;51(9):2638-47.
2008: Brower Evan T; Bacha Usman M; Kawasaki Yuko; Freire Ernesto
Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use.
Chemical biology & drug design 2008;71(4):298-305.
2008: Cremades Nunilo; Velazquez-Campoy Adrián; Freire Ernesto; Sancho Javier
The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.
Biochemistry 2008;47(2):627-39.
2007: Lafont Virginie; Armstrong Anthony A; Ohtaka Hiroyasu; Kiso Yoshiaki; Mario Amzel L; Freire Ernesto
Compensating enthalpic and entropic changes hinder binding affinity optimization.
Chemical biology & drug design 2007;69(6):413-22.
2007: Hidaka Koushi; Kimura Tooru; Tsuchiya Yumi; Kamiya Mami; Ruben Adam J; Freire Ernesto; Hayashi Yoshio; Kiso Yoshiaki
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.
Bioorganic & medicinal chemistry letters 2007;17(11):3048-52.
2007: Muzammil S; Armstrong A A; Kang L W; Jakalian A; Bonneau P R; Schmelmer V; Amzel L M; Freire E
Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.
Journal of virology 2007;81(10):5144-54.
2007: Groesch Teresa D; Freire Ernesto
Characterization of intramolecular interactions of HIV-1 accessory protein Nef by differential scanning calorimetry.
Biophysical chemistry 2007;126(1-3):36-42.
2006: Barrila Jennifer; Bacha Usman; Freire Ernesto
Long-range cooperative interactions modulate dimerization in SARS 3CLpro.
Biochemistry 2006;45(50):14908-16.
2006: Schön Arne; Madani Navid; Klein Jeffrey C; Hubicki Amy; Ng Danny; Yang Xinzhen; Smith Amos B; Sodroski Joseph; Freire Ernesto
Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.
Biochemistry 2006;45(36):10973-80.
2006: Cremades Nunilo; Sancho Javier; Freire Ernesto
The native-state ensemble of proteins provides clues for folding, misfolding and function.
Trends in biochemical sciences 2006;31(9):494-6.
2006: Aguilar Rubén C; Longhi Silvia A; Shaw Jonathan D; Yeh Lan-Yu; Kim Sean; Schön Arne; Freire Ernesto; Hsu Ariel; McCormick William K; Watson Hadiya A; Wendland Beverly
Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4116-21.
2006: Ruben Adam J; Kiso Yoshiaki; Freire Ernesto
Overcoming roadblocks in lead optimization: a thermodynamic perspective.
Chemical biology & drug design 2006;67(1):2-4.
2006: Velazquez-Campoy Adrian; Freire Ernesto
Isothermal titration calorimetry to determine association constants for high-affinity ligands.
Nature protocols 2006;1(1):186-91.
2005: Carbonell Teresa; Freire Ernesto
Binding thermodynamics of statins to HMG-CoA reductase.
Biochemistry 2005;44(35):11741-8.
2005: Murali Ramachandran; Cheng Xin; Berezov Alan; Du Xiulian; Schön Arnie; Freire Ernesto; Xu Xiaowei; Chen Youhai H; Greene Mark I
Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10970-5.
2005: Pancera Marie; Lebowitz Jacob; Schön Arne; Zhu Ping; Freire Ernesto; Kwong Peter D; Roux Kenneth H; Sodroski Joseph; Wyatt Richard
Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: characterization and ligand binding analysis.
Journal of virology 2005;79(15):9954-69.
2005: Ohtaka Hiroyasu; Freire Ernesto
Adaptive inhibitors of the HIV-1 protease.
Progress in biophysics and molecular biology 2005;88(2):193-208.
2005: Velázquez Campoy Adrián; Freire Ernesto
ITC in the post-genomic era...? Priceless.
Biophysical chemistry 2005;115(2-3):115-24.
2004: Abdel-Rahman Hamdy M; Kimura Tooru; Hidaka Koushi; Kiso Aiko; Nezami Azin; Freire Ernesto; Hayashi Yoshio; Kiso Yoshiaki
Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases.
Biological chemistry 2004;385(11):1035-9.
2004: Kiso Aiko; Hidaka Koushi; Kimura Tooru; Hayashi Yoshio; Nezami Azin; Freire Ernesto; Kiso Yoshiaki
Search for substrate-based inhibitors fitting the S2' space of malarial aspartic protease plasmepsin II.
Journal of peptide science : an official publication of the European Peptide Society 2004;10(11):641-7.
2004: Velázquez-Campoy Adrián; Ohtaka Hiroyasu; Nezami Azin; Muzammil Salman; Freire Ernesto
Isothermal titration calorimetry.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 17():Unit 17.8.
2004: Ohtaka Hiroyasu; Muzammil Salman; Schön Arne; Velazquez-Campoy Adrian; Vega Sonia; Freire Ernesto
Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets.
The international journal of biochemistry & cell biology 2004;36(9):1787-99.
2004: Bacha Usman; Barrila Jennifer; Velazquez-Campoy Adrian; Leavitt Stephanie A; Freire Ernesto
Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro.
Biochemistry 2004;43(17):4906-12.
2004: Vega Sonia; Kang Lin-Woo; Velazquez-Campoy Adrian; Kiso Yoshiaki; Amzel L Mario; Freire Ernesto
A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease.
Proteins 2004;55(3):594-602.
2004: Si Zhihai; Madani Navid; Cox Jason M; Chruma Jason J; Klein Jeffrey C; Schön Arne; Phan Ngoc; Wang Liping; Biorn Alyssa C; Cocklin Simon; Chaiken Irwin; Freire Ernesto; Smith Amos B; Sodroski Joseph G
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):5036-41.
2004: Biorn Alyssa C; Cocklin Simon; Madani Navid; Si Zhihai; Ivanovic Tijana; Samanen James; Van Ryk Donald I; Pantophlet Ralph; Burton Dennis R; Freire Ernesto; Sodroski Joseph; Chaiken Irwin M
Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.
Biochemistry 2004;43(7):1928-38.
2004: Leavitt Stephanie A; SchOn Arne; Klein Jeffrey C; Manjappara Uma; Chaiken Irwin M; Freire Ernesto
Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.
Current protein & peptide science 2004;5(1):1-8.
2004: Velazquez-Campoy Adrian; Leavitt Stephanie A; Freire Ernesto
Characterization of protein-protein interactions by isothermal titration calorimetry.
Methods in molecular biology (Clifton, N.J.) 2004;261():35-54.
2003: Velazquez-Campoy Adrian; Muzammil Salman; Ohtaka Hiroyasu; Schön Arne; Vega Sonia; Freire Ernesto
Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design.
Current drug targets. Infectious disorders 2003;3(4):311-28.
2003: Ohtaka Hiroyasu; Schön Arne; Freire Ernesto
Multidrug resistance to HIV-1 protease inhibition requires cooperative coupling between distal mutations.
Biochemistry 2003;42(46):13659-66.
2003: Schön Arne; del Mar Ingaramo Maria; Freire Ernesto
The binding of HIV-1 protease inhibitors to human serum proteins.
Biophysical chemistry 2003;105(2-3):221-30.
2003: Velázquez-Campoy Adrián; Vega Sonia; Fleming Erin; Bacha Usman; Sayed Yasien; Dirr Heini W; Freire Ernesto
Protease inhibition in African subtypes of HIV-1.
AIDS reviews 2003;5(3):165-71.
2003: Nezami Azin; Kimura Tooru; Hidaka Koushi; Kiso Aiko; Liu Jun; Kiso Yoshiaki; Goldberg Daniel E; Freire Ernesto
High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.
Biochemistry 2003;42(28):8459-64.
2003: Muzammil Salman; Ross Patrick; Freire Ernesto
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry 2003;42(3):631-8.
2002: Kwong Peter D; Doyle Michael L; Casper David J; Cicala Claudia; Leavitt Stephanie A; Majeed Shahzad; Steenbeke Tavis D; Venturi Miro; Chaiken Irwin; Fung Michael; Katinger Hermann; Parren Paul W I H; Robinson James; Van Ryk Donald; Wang Liping; Burton Dennis R; Freire Ernesto; Wyatt Richard; Sodroski Joseph; Hendrickson Wayne A; Arthos James
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Nature 2002;420(6916):678-82.
2002: Nezami Azin; Freire Ernesto
The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors.
International journal for parasitology 2002;32(13):1669-76.
2002: Luque Irene; Freire Ernesto
Structural parameterization of the binding enthalpy of small ligands.
Proteins 2002;49(2):181-90.
2002: Ohtaka Hiroyasu; Velázquez-Campoy Adrian; Xie Dong; Freire Ernesto
Overcoming drug resistance in HIV-1 chemotherapy: the binding thermodynamics of Amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease.
Protein science : a publication of the Protein Society 2002;11(8):1908-16.
2002: Velazquez-Campoy Adrian; Vega Sonia; Freire Ernesto
Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes.
Biochemistry 2002;41(27):8613-9.
2002: Dowd Cynthia S; Leavitt Stephanie; Babcock Gregory; Godillot Alexis P; Van Ryk Don; Canziani Gabriela A; Sodroski Joseph; Freire Ernesto; Chaiken Irwin M
Beta-turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site.
Biochemistry 2002;41(22):7038-46.
2002: Nezami Azin; Luque Irene; Kimura Tooru; Kiso Yoshiaki; Freire Ernesto
Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.
Biochemistry 2002;41(7):2273-80.
2002: Freire Ernesto
Designing drugs against heterogeneous targets.
Nature biotechnology 2002;20(1):15-6.
2002: Luque Irene; Leavitt Stephanie A; Freire Ernesto
The linkage between protein folding and functional cooperativity: two sides of the same coin?
Annual review of biophysics and biomolecular structure 2002;31():235-56.
2001: Leavitt S; Freire E
Direct measurement of protein binding energetics by isothermal titration calorimetry.
Current opinion in structural biology 2001;11(5):560-6.
2001: Karantza V; Freire E; Moudrianakis E N
Thermodynamic studies of the core histones: stability of the octamer subunits is not altered by removal of their terminal domains.
Biochemistry 2001;40(43):13114-23.
2001: Velazquez-Campoy A; Kiso Y; Freire E
The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design.
Archives of biochemistry and biophysics 2001;390(2):169-75.
2001: Velazquez-Campoy A; Todd M J; Vega S; Freire E
Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6062-7.
2001: Velazquez-Campoy A; Freire E
Incorporating target heterogeneity in drug design.
Journal of cellular biochemistry. Supplement 2001;Suppl 37():82-8.
2001: Freire E
The thermodynamic linkage between protein structure, stability, and function.
Methods in molecular biology (Clifton, N.J.) 2001;168():37-68.
2000: Freire E
Can allosteric regulation be predicted from structure?
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11680-2.
2000: Todd M J; Luque I; Velázquez-Campoy A; Freire E
Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant.
Biochemistry 2000;39(39):11876-83.
2000: Velazquez-Campoy A; Luque I; Todd M J; Milutinovich M; Kiso Y; Freire E
Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor.
Protein science : a publication of the Protein Society 2000;9(9):1801-9.
2000: Velazquez-Campoy A; Todd M J; Freire E
HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity.
Biochemistry 2000;39(9):2201-7.
2000: D'Aquino J A; Freire E; Amzel L M
Binding of small organic molecules to macromolecular targets: evaluation of conformational entropy changes.
Proteins 2000;Suppl 4():93-107.
2000: Luque I; Freire E
Structural stability of binding sites: consequences for binding affinity and allosteric effects.
Proteins 2000;Suppl 4():63-71.
1999: Freire E
The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10118-22.
1999: Todd M J; Freire E
The effect of inhibitor binding on the structural stability and cooperativity of the HIV-1 protease.
Proteins 1999;36(2):147-56.
1999: Sadqi M; Casares S; Abril M A; López-Mayorga O; Conejero-Lara F; Freire E
The native state conformational ensemble of the SH3 domain from alpha-spectrin.
Biochemistry 1999;38(28):8899-906.
1999: Kholodenko V; Freire E
A simple method to measure the absolute heat capacity of proteins.
Analytical biochemistry 1999;270(2):336-8.
1998: Todd M J; Semo N; Freire E
The structural stability of the HIV-1 protease.
Journal of molecular biology 1998;283(2):475-88.
1998: Hilser V J; Dowdy D; Oas T G; Freire E
The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9903-8.
1998: Milstein S J; Leipold H; Sarubbi D; Leone-Bay A; Mlynek G M; Robinson J R; Kasimova M; Freire E
Partially unfolded proteins efficiently penetrate cell membranes--implications for oral drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):259-67.
1998: Luque I; Todd M J; Gómez J; Semo N; Freire E
Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis.
Biochemistry 1998;37(17):5791-7.
1998: Kasimova M R; Milstein S J; Freire E
The conformational equilibrium of human growth hormone.
Journal of molecular biology 1998;277(2):409-18.
1998: Luque I; Gómez J; Semo N; Freire E
Structure-based thermodynamic design of peptide ligands: application to peptide inhibitors of the aspartic protease endothiapepsin.
Proteins 1998;30(1):74-85.
1998: Luque I; Freire E
Structure-based prediction of binding affinities and molecular design of peptide ligands.
Methods in enzymology 1998;295():100-27.
1998: Freire E
Statistical thermodynamic linkage between conformational and binding equilibria.
Advances in protein chemistry 1998;51():255-79.
1998: Gómez J; Semo N; Freire E
Structural thermodynamic study of the binding of renin inhibitors to endothiapepsin.
Advances in experimental medicine and biology 1998;436():325-8.
1997: Boudker O; Todd M J; Freire E
The structural stability of the co-chaperonin GroES.
Journal of molecular biology 1997;272(5):770-9.
1997: Bardi J S; Luque I; Freire E
Structure-based thermodynamic analysis of HIV-1 protease inhibitors.
Biochemistry 1997;36(22):6588-96.
1997: Hilser V J; Townsend B D; Freire E
Structure-based statistical thermodynamic analysis of T4 lysozyme mutants: structural mapping of cooperative interactions.
Biophysical chemistry 1997;64(1-3):69-79.
1997: Hilser V J; Freire E
Predicting the equilibrium protein folding pathway: structure-based analysis of staphylococcal nuclease.
Proteins 1997;27(2):171-83.
1996: Hilser V J; Gómez J; Freire E
The enthalpy change in protein folding and binding: refinement of parameters for structure-based calculations.
Proteins 1996;26(2):123-33.
1996: Luque I; Mayorga O L; Freire E
Structure-based thermodynamic scale of alpha-helix propensities in amino acids.
Biochemistry 1996;35(42):13681-8.
1996: Hilser V J; Freire E
Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.
Journal of molecular biology 1996;262(5):756-72.
1996: D'Aquino J A; Gómez J; Hilser V J; Lee K H; Amzel L M; Freire E
The magnitude of the backbone conformational entropy change in protein folding.
Proteins 1996;25(2):143-56.
1996: Johnson C R; Angeletti M; Pucciarelli S; Freire E
Oxygen binding to fallow-deer (Dama dama) hemoglobin: stepwise enthalpies at pH 7.4.
Biophysical chemistry 1996;59(1-2):107-17.
1996: Karantza V; Freire E; Moudrianakis E N
Thermodynamic studies of the core histones: pH and ionic strength effects on the stability of the (H3-H4)/(H3-H4)2 system.
Biochemistry 1996;35(6):2037-46.
1995: Privalov G; Kavina V; Freire E; Privalov P L
Precise scanning calorimeter for studying thermal properties of biological macromolecules in dilute solution.
Analytical biochemistry 1995;232(1):79-85.
1995: Echabe I; Haltia T; Freire E; Goñi F M; Arrondo J L
Subunit III of cytochrome c oxidase influences the conformation of subunits I and II: an infrared study.
Biochemistry 1995;34(41):13565-9.
1995: Kenar K T; García-Moreno B; Freire E
A calorimetric characterization of the salt dependence of the stability of the GCN4 leucine zipper.
Protein science : a publication of the Protein Society 1995;4(9):1934-8.
1995: Griko Y V; Freire E; Privalov G; van Dael H; Privalov P L
The unfolding thermodynamics of c-type lysozymes: a calorimetric study of the heat denaturation of equine lysozyme.
Journal of molecular biology 1995;252(4):447-59.
1995: Gómez J; Freire E
Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin.
Journal of molecular biology 1995;252(3):337-50.
1995: Gómez J; Hilser V J; Xie D; Freire E
The heat capacity of proteins.
Proteins 1995;22(4):404-12.
1995: Haltia T; Freire E
Forces and factors that contribute to the structural stability of membrane proteins.
Biochimica et biophysica acta 1995;1241(2):295-322.
1995: Karantza V; Baxevanis A D; Freire E; Moudrianakis E N
Thermodynamic studies of the core histones: ionic strength and pH dependence of H2A-H2B dimer stability.
Biochemistry 1995;34(17):5988-96.
1995: Johnson C R; Morin P E; Arrowsmith C H; Freire E
Thermodynamic analysis of the structural stability of the tetrameric oligomerization domain of p53 tumor suppressor.
Biochemistry 1995;34(16):5309-16.
1995: Todd M J; Boudkin O; Freire E; Lorimer G H
GroES and the chaperonin-assisted protein folding cycle: GroES has no affinity for nucleotides.
FEBS letters 1995;359(2-3):123-5.
1995: Haltia T; Freire E
Forces and factors that contribute to the structural stability of membrane proteins.
Biochimica et biophysica acta 1995;1228(1):1-27.
1995: Murphy K P; Freire E; Paterson Y
Configurational effects in antibody-antigen interactions studied by microcalorimetry.
Proteins 1995;21(2):83-90.
1995: Hilser V J; Freire E
Quantitative analysis of conformational equilibrium using capillary electrophoresis: applications to protein folding.
Analytical biochemistry 1995;224(2):465-85.
1995: Murphy K P; Freire E
Thermodynamic strategies for rational protein and drug design.
Pharmaceutical biotechnology 1995;7():219-41.
1995: Freire E
Thermal denaturation methods in the study of protein folding.
Methods in enzymology 1995;259():144-68.
1995: Freire E
Thermodynamics of partly folded intermediates in proteins.
Annual review of biophysics and biomolecular structure 1995;24():141-65.
1995: Freire E
Differential scanning calorimetry.
Methods in molecular biology (Clifton, N.J.) 1995;40():191-218.
1994: Xie D; Fox R; Freire E
Thermodynamic characterization of an equilibrium folding intermediate of staphylococcal nuclease.
Protein science : a publication of the Protein Society 1994;3(12):2175-84.
1994: Xie D; Freire E
Structure based prediction of protein folding intermediates.
Journal of molecular biology 1994;242(1):62-80.
1994: Lee K H; Xie D; Freire E; Amzel L M
Estimation of changes in side chain configurational entropy in binding and folding: general methods and application to helix formation.
Proteins 1994;20(1):68-84.
1994: Haltia T; Semo N; Arrondo J L; Goñi F M; Freire E
Thermodynamic and structural stability of cytochrome c oxidase from Paracoccus denitrificans.
Biochemistry 1994;33(32):9731-40.
1994: Xie D; Freire E
Molecular basis of cooperativity in protein folding. V. Thermodynamic and structural conditions for the stabilization of compact denatured states.
Proteins 1994;19(4):291-301.
1994: Freire E; Xie D
Thermodynamic prediction of structural determinants of the molten globule state of barnase.
Biophysical chemistry 1994;51(2-3):243-51.
1994: Haynie D T; Freire E
Thermodynamic strategies for stabilizing intermediate states of proteins.
Biopolymers 1994;34(2):261-72.
1994: Griko Y V; Freire E; Privalov P L
Energetics of the alpha-lactalbumin states: a calorimetric and statistical thermodynamic study.
Biochemistry 1994;33(7):1889-99.
1994: Murphy K P; Xie D; Thompson K S; Amzel L M; Freire E
Entropy in biological binding processes: estimation of translational entropy loss.
Proteins 1994;18(1):63-7.
1994: Haynie D T; Freire E
Estimation of the folding/unfolding energetics of marginally stable proteins using differential scanning calorimetry.
Analytical biochemistry 1994;216(1):33-41.
1994: Freire E
Statistical thermodynamic analysis of differential scanning calorimetry data: structural deconvolution of heat capacity function of proteins.
Methods in enzymology 1994;240():502-30.
1993: Wang Z Y; Freire E; McCarty R E
Influence of nucleotide binding site occupancy on the thermal stability of the F1 portion of the chloroplast ATP synthase.
The Journal of biological chemistry 1993;268(28):20785-90.
1993: Freire E; Haynie D T; Xie D
Molecular basis of cooperativity in protein folding. IV. CORE: a general cooperative folding model.
Proteins 1993;17(2):111-23.
1993: Xie D; Bhakuni V; Freire E
Are the molten globule and the unfolded states of apo-alpha-lactalbumin enthalpically equivalent?
Journal of molecular biology 1993;232(1):5-8.
1993: Montgomery D; Jordan R; McMacken R; Freire E
Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli molecular chaperone DnaK.
Journal of molecular biology 1993;232(2):680-92.
1993: Freire E
Structural thermodynamics: prediction of protein stability and protein binding affinities.
Archives of biochemistry and biophysics 1993;303(2):181-4.
1993: Thompson K S; Vinson C R; Freire E
Thermodynamic characterization of the structural stability of the coiled-coil region of the bZIP transcription factor GCN4.
Biochemistry 1993;32(21):5491-6.
1993: Haynie D T; Freire E
Structural energetics of the molten globule state.
Proteins 1993;16(2):115-40.
1993: Murphy K P; Xie D; Garcia K C; Amzel L M; Freire E
Structural energetics of peptide recognition: angiotensin II/antibody binding.
Proteins 1993;15(2):113-20.
1993: Hilser V J; Worosila G D; Freire E
Analysis of thermally induced protein folding/unfolding transitions using free solution capillary electrophoresis.
Analytical biochemistry 1993;208(1):125-31.
1992: Bains G; Lee R T; Lee Y C; Freire E
Microcalorimetric study of wheat germ agglutinin binding to N-acetylglucosamine and its oligomers.
Biochemistry 1992;31(50):12624-8.
1992: Plaza del Pino I M; Pace C N; Freire E
Temperature and guanidine hydrochloride dependence of the structural stability of ribonuclease T1.
Biochemistry 1992;31(45):11196-202.
1992: Fu L; Freire E
On the origin of the enthalpy and entropy convergence temperatures in protein folding.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9335-8.
1992: Murphy K P; Bhakuni V; Xie D; Freire E
Molecular basis of co-operativity in protein folding. III. Structural identification of cooperative folding units and folding intermediates.
Journal of molecular biology 1992;227(1):293-306.
1992: Straume M; Freire E
Two-dimensional differential scanning calorimetry: simultaneous resolution of intrinsic protein structural energetics and ligand binding interactions by global linkage analysis.
Analytical biochemistry 1992;203(2):259-68.
1992: Masserini M; Freire E; Palestini P; Calappi E; Tettamanti G
Fuc-GM1 ganglioside mimics the receptor function of GM1 for cholera toxin.
Biochemistry 1992;31(8):2422-6.
1992: Freire E; Murphy K P; Sanchez-Ruiz J M; Galisteo M L; Privalov P L
The molecular basis of cooperativity in protein folding. Thermodynamic dissection of interdomain interactions in phosphoglycerate kinase.
Biochemistry 1992;31(1):250-6.
1992: Murphy K P; Freire E
Thermodynamics of structural stability and cooperative folding behavior in proteins.
Advances in protein chemistry 1992;43():313-61.
1992: Breslauer K J; Freire E; Straume M
Calorimetry: a tool for DNA and ligand-DNA studies.
Methods in enzymology 1992;211():533-67.
1991: Freire E; Murphy K P
Molecular basis of co-operativity in protein folding.
Journal of molecular biology 1991;222(3):687-98.
1991: Xie D; Bhakuni V; Freire E
Calorimetric determination of the energetics of the molten globule intermediate in protein folding: apo-alpha-lactalbumin.
Biochemistry 1991;30(44):10673-8.
1991: LiCalsi C; Crocenzi T S; Freire E; Roseman S
Sugar transport by the bacterial phosphotransferase system. Structural and thermodynamic domains of enzyme I of Salmonella typhimurium.
The Journal of biological chemistry 1991;266(29):19519-27.
1991: Morin P E; Freire E
Direct calorimetric analysis of the enzymatic activity of yeast cytochrome c oxidase.
Biochemistry 1991;30(34):8494-500.
1991: Bhakuni V; Xie D; Freire E
Thermodynamic identification of stable folding intermediates in the B-subunit of cholera toxin.
Biochemistry 1991;30(20):5055-60.
1991: Bains G; Freire E
Calorimetric determination of cooperative interactions in high affinity binding processes.
Analytical biochemistry 1991;192(1):203-6.
1991: van Osdol W W; Mayorga O L; Freire E
Multifrequency calorimetry of the folding/unfolding transition of cytochrome c.
Biophysical journal 1991;59(1):48-54.
1990: Ramsay G; Freire E
Linked thermal and solute perturbation analysis of cooperative domain interactions in proteins. Structural stability of diphtheria toxin.
Biochemistry 1990;29(37):8677-83.
1990: Morin P E; Diggs D; Freire E
Thermal stability of membrane-reconstituted yeast cytochrome c oxidase.
Biochemistry 1990;29(3):781-8.
1990: Freire E; van Osdol W W; Mayorga O L; Sanchez-Ruiz J M
Calorimetrically determined dynamics of complex unfolding transitions in proteins.
Annual review of biophysics and biophysical chemistry 1990;19():159-88.
1989: Na G C; Phillips L J; Freire E I
In vitro collagen fibril assembly: thermodynamic studies.
Biochemistry 1989;28(18):7153-61.
1989: Masserini M; Palestini P; Freire E
Influence of glycolipid oligosaccharide and long-chain base composition on the thermotropic properties of dipalmitoylphosphatidylcholine large unilamellar vesicles containing gangliosides.
Biochemistry 1989;28(12):5029-34.
1989: Schön A; Freire E
Thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside GM1.
Biochemistry 1989;28(12):5019-24.
1989: Bradrick T D; Freire E; Georghiou S
A high-sensitivity differential scanning calorimetric study of the interaction of melittin with dipalmitoylphosphatidylcholine fused unilamellar vesicles.
Biochimica et biophysica acta 1989;982(1):94-102.
1989: Ramsay G; Montgomery D; Berger D; Freire E
Energetics of diphtheria toxin membrane insertion and translocation: calorimetric characterization of the acid pH induced transition.
Biochemistry 1989;28(2):529-33.
1988: Mayorga O L; van Osdol W W; Lacomba J L; Freire E
Frequency spectrum of enthalpy fluctuations associated with macromolecular transitions.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9514-8.
1988: Stearman R S; Frankel A D; Freire E; Liu B S; Pabo C O
Combining thermostable mutations increases the stability of lambda repressor.
Biochemistry 1988;27(19):7571-4.
1988: Shortle D; Meeker A K; Freire E
Stability mutants of staphylococcal nuclease: large compensating enthalpy-entropy changes for the reversible denaturation reaction.
Biochemistry 1988;27(13):4761-8.
1988: Goins B; Freire E
Thermal stability and intersubunit interactions of cholera toxin in solution and in association with its cell-surface receptor ganglioside GM1.
Biochemistry 1988;27(6):2046-52.
1987: Myers M; Mayorga O L; Emtage J; Freire E
Thermodynamic characterization of interactions between ornithine transcarbamylase leader peptide and phospholipid bilayer membranes.
Biochemistry 1987;26(14):4309-15.
1987: Lopez Mayorga O; Freire E
Dynamic analysis of differential scanning calorimetry data.
Biophysical chemistry 1987;27(1):87-96.
1987: Rigell C W; Freire E
Differential detergent solubility investigation of thermally induced transitions in cytochrome c oxidase.
Biochemistry 1987;26(14):4366-71.
1987: Tsao Y S; Freire E; Huang L
Thermodynamic and phase characterization of phosphatidylethanolamine and ganglioside GD1a mixtures.
Biochimica et biophysica acta 1987;900(1):79-87.
1987: Masserini M; Freire E
Kinetics of ganglioside transfer between liposomal and synaptosomal membranes.
Biochemistry 1987;26(1):237-42.
1986: Goins B; Masserini M; Barisas B G; Freire E
Lateral diffusion of ganglioside GM1 in phospholipid bilayer membranes.
Biophysical journal 1986;49(4):849-56.
1986: Ramsay G; Prabhu R; Freire E
Direct measurement of the energetics of association between myelin basic protein and phosphatidylserine vesicles.
Biochemistry 1986;25(8):2265-70.
1986: Masserini M; Freire E
Thermotropic characterization of phosphatidylcholine vesicles containing ganglioside GM1 with homogeneous ceramide chain length.
Biochemistry 1986;25(5):1043-9.
1985: Rigell C W; de Saussure C; Freire E
Protein and lipid structural transitions in cytochrome c oxidase-dimyristoylphosphatidylcholine reconstitutions.
Biochemistry 1985;24(20):5638-46.
1985: Myers M; Freire E
Calorimetric and fluorescence characterization of interactions between enkephalins and liposomal and synaptic plasma membranes containing gangliosides.
Biochemistry 1985;24(15):4076-82.
1985: Goins B; Freire E
Lipid phase separations induced by the association of cholera toxin to phospholipid membranes containing ganglioside GM1.
Biochemistry 1985;24(7):1791-7.
1984: Babbitt B; Huang L; Freire E
Thermotropic and dynamic characterization of interactions of acylated alpha-bungarotoxin with phospholipid bilayer membranes.
Biochemistry 1984;23(17):3920-6.
1984: Myers M; Wortman C; Freire E
Modulation of neuraminidase activity by the physical state of phospholipid bilayers containing gangliosides Gd1a and Gt1b.
Biochemistry 1984;23(7):1442-8.
1983: Freire E; Markello T; Rigell C; Holloway P W
Calorimetric and fluorescence characterization of interactions between cytochrome b5 and phosphatidylcholine bilayers.
Biochemistry 1983;22(7):1675-80.
1982: Snyder B; Freire E
Fluorescence energy transfer in two dimensions. A numeric solution for random and nonrandom distributions.
Biophysical journal 1982;40(2):137-48.
1982: Freire E; Snyder B
Quantitative characterization of the lateral distribution of membrane proteins within the lipid bilayer.
Biophysical journal 1982;37(3):617-24.
1981: Estep T N; Freire E; Anthony F; Barenholz Y; Biltonen R L; Thompson T E
Thermal behavior of stearoylsphingomyelin-cholesterol dispersions.
Biochemistry 1981;20(25):7115-8.
1981: Anthony F H; Biltonen R L; Freire E
Modification of a vibrating-tube density meter for precise temperature scanning.
Analytical biochemistry 1981;116(1):161-7.
1981: Lichtenberg D; Freire E; Schmidt C F; Barenholz Y; Felgner P L; Thompson T E
Effect of surface curvature on stability, thermodynamic behavior, and osmotic activity of dipalmitoylphosphatidylcholine single lamellar vesicles.
Biochemistry 1981;20(12):3462-7.
1981: Felgner P L; Freire E; Barenholz Y; Thompson T E
Asymmetric incorporation of trisialoganglioside into dipalmitoylphosphatidylcholine vesicles.
Biochemistry 1981;20(8):2168-72.
1980: Freire E; Bach D; Correa-Freire M; Miller I; Barenholz Y
Calorimetric investigation of the complex phase behavior of glucocerebroside dispersions.
Biochemistry 1980;19(16):3662-5.
1980: Snyder B; Freire E
Compositional domain structure in phosphatidylcholine--cholesterol and sphingomyelin--cholesterol bilayers.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):4055-9.
1980: Freire E; Snyder B
Estimation of the lateral distribution of molecules in two-component lipid bilayers.
Biochemistry 1980;19(1):88-94.
1980: Robinson B H; Sherwood W G; Mayes S; Freire E; Oei J; DiBattista D
Factors affecting glucose turnover and utilization in the neonatal subhuman primate (Macaca mulatta).
Biology of the neonate 1980;37(1-2):60-6.
1979: Correa-Freire M C; Freire E; Barenholz Y; Biltonen R L; Thompson T E
Thermotropic behavior of monoglucocerebroside--dipalmitoylphosphatidylcholine multilamellar liposomes.
Biochemistry 1979;18(3):442-5.
1978: Freire E; Biltonen R
Estimation of molecular averages and equilibrium fluctuations in lipid bilayer systems from the excess heat capacity function.
Biochimica et biophysica acta 1978;514(1):54-68.
1978: Lentz B R; Freire E; Biltonen R L
Fluorescence and calorimetric studies of phase transitions in phosphatidylcholine multilayers: kinetics of the pretransition.
Biochemistry 1978;17(21):4475-80.
1978: Freire E; Biltonen R L
Thermodynamics of transfer ribonucleic acids: the effect of sodium on the thermal unfolding of yeast tRNAPhe.
Biopolymers 1978;17(5):1257-72.
1978: Biltonen R L; Freire E
Thermodynamic characterization of conformational states of biological macromolecules using differential scanning calorimetry.
CRC critical reviews in biochemistry 1978;5(2):85-124.
1977: Suurkuusk J; Alvarez J; Freire E; Biltonen R
Calorimetric determination of the heat capacity changes associated with the conformational transitions of polyriboadenylic acid and polyribouridylic acid.
Biopolymers 1977;16(12):2641-52.

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