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Ernesto Freire

Research Profile

Occupations

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Physiology

Protein Folding

Chemicals & Drugs

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TOP 3
Kantharaju Kamanna; Pamela Kubinski; Karyn McFadden; Diogo Rodrigo Moreira; Arne Schön; Ferit Tuzer; Mark Contarino; Caitlin Duffy; Ernesto Freire; Andrew Holmes; Rachna Aneja; Lauren D Bailey; Irwin Chaiken
Non-natural peptide triazole antagonists of HIV-1 envelope gp120.
Sho Konno; Kiyohiko Nakada; Kentaro Takayama; Pillaiyar Thanigaimalai; Fumika Yakushiji; Takehito Yamamoto; Yuri Yamazaki; Kenichi Akaji; Shen-En Chen; Ernesto Freire; Rie Kakiuchi; Yuko Kawasaki; Yoshiaki Kiso; Yoshio Hayashi
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.
Yingyun Liu; Arne Schön; Ernesto Freire
Optimization of CD4/gp120 inhibitors by thermodynamic-guided alanine-scanning mutagenesis.

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All Publications

2013: Kantharaju Kamanna; Pamela Kubinski; Karyn McFadden; Diogo Rodrigo Moreira; Arne Schön; Ferit Tuzer; Mark Contarino; Caitlin Duffy; Ernesto Freire; Andrew Holmes; Rachna Aneja; Lauren D Bailey; Irwin Chaiken
Non-natural peptide triazole antagonists of HIV-1 envelope gp120.
ChemMedChem 2013;8(2):322-8.
2013: Sho Konno; Kiyohiko Nakada; Kentaro Takayama; Pillaiyar Thanigaimalai; Fumika Yakushiji; Takehito Yamamoto; Yuri Yamazaki; Kenichi Akaji; Shen-En Chen; Ernesto Freire; Rie Kakiuchi; Yuko Kawasaki; Yoshiaki Kiso; Yoshio Hayashi
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.
Bioorganic & medicinal chemistry 2013;21(2):412-24.
2013: Yingyun Liu; Arne Schön; Ernesto Freire
Optimization of CD4/gp120 inhibitors by thermodynamic-guided alanine-scanning mutagenesis.
Chemical biology & drug design 2013;81(1):72-8.
2012: Marino J E Resendiz; Arne Schön; Ernesto Freire; Marc M Greenberg
Photochemical control of RNA structure by disrupting π-stacking.
Journal of the American Chemical Society 2012;134(30):12478-81.
2012: Sandhya Kortagere; Fred C Krebs; Navid Madani; Marie K Mankowski; Julio Martín-García; Apara Oza; Shendra R Passic; Amy Princiotto; Roger G Ptak; Arne Schön; Luz-Jeannette Sierra; Kevin Anthony; Simon Cocklin; Ernesto Freire; David M Jones; Joseph Sodroski; Eric Stavale; Gokul Swaminathan; Xiaozhao Wang; Isaac Zentner; Amos B Smith
Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid.
Journal of virology 2012;86(16):8472-81.
2012: Judith M LaLonde; Navid Madani; John R Mascola; Amy M Princiotto; Arne Schön; Joel R Courter; Ernesto Freire; David M Jones; Toyoharu Kobayashi; Young Do Kwon; Peter D Kwong; Joseph Sodroski; Takahiro Soeta; Alexander W Sun; Xueling Wu; Amos B Smith
Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors.
Journal of medicinal chemistry 2012;55(9):4382-96.
2011: Yuko Kawasaki; Ernesto Freire
Finding a better path to drug selectivity.
Drug discovery today 2011;16(21-22):985-90.
2011: Rogelio Siles; Yuko Kawasaki; Patrick Ross; Ernesto Freire
Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases.
Bioorganic & medicinal chemistry letters 2011;21(18):5305-9.
2011: Arne Schön; Sonia Y Lam; Ernesto Freire
Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions.
Future medicinal chemistry 2011;3(9):1129-37.
2011: Syna Kuriakose Gift; Isaac J Zentner; Arne Schön; Karyn McFadden; M Umashankara; Srivats Rajagopal; Mark Contarino; Caitlin Duffy; Joel R Courter; Mei-Yun Zhang; Jonathan M Gershoni; Simon Cocklin; Dimiter S Dimitrov; Amos B Smith; Ernesto Freire; Irwin Chaiken
Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.
Biochemistry 2011;50(14):2756-68.
2011: Arne Schön; Navid Madani; Amos B Smith; Judith M Lalonde; Ernesto Freire
Some binding-related drug properties are dependent on thermodynamic signature.
Chemical biology & drug design 2011;77(3):161-5.
2011: Judith M Lalonde; Mark A Elban; Joel R Courter; Akihiro Sugawara; Takahiro Soeta; Navid Madani; Amy M Princiotto; Young Do Kwon; Peter D Kwong; Arne Schön; Ernesto Freire; Joseph Sodroski; Amos B Smith
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.
Bioorganic & medicinal chemistry 2011;19(1):91-101.
2010: Muddegowda Umashankara; Karyn McFadden; Isaac Zentner; Arne Schön; Srivats Rajagopal; Ferit Tuzer; Syna A Kuriakose; Mark Contarino; Judith Lalonde; Ernesto Freire; Irwin Chaiken
The active core in a triazole peptide dual-site antagonist of HIV-1 gp120.
ChemMedChem 2010;5(11):1871-9.
2010: Takuya Miura; Koushi Hidaka; Tsuyoshi Uemura; Keisuke Kashimoto; Yuto Hori; Yuko Kawasaki; Adam J Ruben; Ernesto Freire; Tooru Kimura; Yoshiaki Kiso
Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.
Bioorganic & medicinal chemistry letters 2010;20(16):4836-9.
2010: Jennifer Barrila; Sandra B. Gabelli; Usman Bacha; Mario Amzel; Ernesto Freire
Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) .
Biochemistry 2010;49(20):4308-17.
2010: Evan T Brower; Arne Schön; Ernesto Freire
Naturally occurring variability in the envelope glycoprotein of HIV-1 and development of cell entry inhibitors.
Biochemistry 2010;49(11):2359-67.
2010: Yuko Kawasaki; Eduardo E Chufan; Virginie Lafont; Koushi Hidaka; Yoshiaki Kiso; L Mario Amzel; Ernesto Freire
How much binding affinity can be gained by filling a cavity?
Chemical biology & drug design 2010;75(2):143-51.
2010: Hyun-Su Lee; Mark Contarino; M Umashankara; Arne Schön; Ernesto Freire; Amos B Smith; Irwin M Chaiken; Lynn S Penn
Use of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120.
Analytical and bioanalytical chemistry 2010;396(3):1143-52.
2010: John E Ladbury; Gerhard Klebe; Ernesto Freire
Adding calorimetric data to decision making in lead discovery: a hot tip.
Nature reviews. Drug discovery 2010;9(1):23-7.
2009: Ernesto Freire
A thermodynamic approach to the affinity optimization of drug candidates.
Chemical biology & drug design 2009;74(5):468-72.
2009: Aemro Kassa; Navid Madani; Arne Schön; Hillel Haim; Andrés Finzi; Shi-Hua Xiang; Liping Wang; Amy Princiotto; Marie Pancera; Joel Courter; Amos B Smith; Ernesto Freire; Peter D Kwong; Joseph Sodroski
Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain.
Journal of virology 2009;83(17):8364-78.
2009: Chunlong Ma; Alexei L Polishchuk; Yuki Ohigashi; Amanda L Stouffer; Arne Schön; Emma Magavern; Xianghong Jing; James D Lear; Ernesto Freire; Robert A Lamb; William F DeGrado; Lawrence H Pinto
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12283-8.
2009: Thomas Regnier; Diganta Sarma; Koushi Hidaka; Usman Bacha; Ernesto Freire; Yoshio Hayashi; Yoshiaki Kiso
New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(10):2722-7.
2009: Evan T Brower; Arne Schön; Jeffrey C Klein; Ernesto Freire
Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120.
Biochemistry 2009;48(4):779-85.
2009: Ernesto Freire; Arne Schön; Adrian Velazquez-Campoy
Isothermal titration calorimetry: general formalism using binding polynomials.
Methods in enzymology 2009;455():127-55.
2008: Koushi Hidaka; Tooru Kimura; Adam J Ruben; Tsuyoshi Uemura; Mami Kamiya; Aiko Kiso; Tetsuya Okamoto; Yumi Tsuchiya; Yoshio Hayashi; Ernesto Freire; Yoshiaki Kiso
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Bioorganic & medicinal chemistry 2008;16(23):10049-60.
2008: Navid Madani; Arne Schön; Amy M Princiotto; Judith M Lalonde; Joel R Courter; Takahiro Soeta; Danny Ng; Liping Wang; Evan T Brower; Shi-Hua Xiang; Young Do Kwon; Chih-Chin Huang; Richard Wyatt; Peter D Kwong; Ernesto Freire; Amos B Smith; Joseph Sodroski
Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.
Structure (London, England : 1993) 2008;16(11):1689-701.
2008: Ernesto Freire
Do enthalpy and entropy distinguish first in class from best in class?
Drug discovery today 2008;13(19-20):869-74.
2008: Usman Bacha; Jennifer Barrila; Sandra B. Gabelli; Yoshiaki Kiso; L Mario Amzel; Ernesto Freire
Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro).
Chemical biology & drug design 2008;72(1):34-49.
2008: Hosahudya Gopi; M Umashankara; Vanessa Pirrone; Judith LaLonde; Navid Madani; Ferit Tuzer; Sabine Baxter; Isaac Zentner; Simon Cocklin; Navneet Jawanda; Shendra R Miller; Arne Schön; Jeffrey C Klein; Ernesto Freire; Fred C Krebs; Amos B Smith; Joseph Sodroski; Irwin Chaiken
Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.
Journal of medicinal chemistry 2008;51(9):2638-47.
2008: Evan T Brower; Usman M Bacha; Yuko Kawasaki; Ernesto Freire
Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use.
Chemical biology & drug design 2008;71(4):298-305.
2008: Nunilo Cremades; Adrian Velazquez-Campoy; Ernesto Freire; javier sancho
The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.
Biochemistry 2008;47(2):627-39.
2007: Virginie Lafont; Anthony A Armstrong; Hiroyasu Ohtaka; Yoshiaki Kiso; L Mario Amzel; Ernesto Freire
Compensating enthalpic and entropic changes hinder binding affinity optimization.
Chemical biology & drug design 2007;69(6):413-22.
2007: Koushi Hidaka; Tooru Kimura; Yumi Tsuchiya; Mami Kamiya; Adam J Ruben; Ernesto Freire; Yoshio Hayashi; Yoshiaki Kiso
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.
Bioorganic & medicinal chemistry letters 2007;17(11):3048-52.
2007: Salman Muzammil; Anthony A Armstrong; Lin-Woo Kang; Araz Jakalian; Pierre R Bonneau; V Schmelmer; Mario Amzel; Ernesto Freire
Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.
Journal of virology 2007;81(10):5144-54.
2007: Teresa D Groesch; Ernesto Freire
Characterization of intramolecular interactions of HIV-1 accessory protein Nef by differential scanning calorimetry.
Biophysical chemistry 2007;126(1-3):36-42.
2006: Jennifer Barrila; Usman Bacha; Ernesto Freire
Long-range cooperative interactions modulate dimerization in SARS 3CLpro.
Biochemistry 2006;45(50):14908-16.
2006: Arne Schön; Navid Madani; Jeffrey C Klein; Amy Hubicki; Danny Ng; Xinzhen Yang; Amos B Smith; Joseph Sodroski; Ernesto Freire
Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.
Biochemistry 2006;45(36):10973-80.
2006: Nunilo Cremades; javier sancho; Ernesto Freire
The native-state ensemble of proteins provides clues for folding, misfolding and function.
Trends in biochemical sciences 2006;31(9):494-6.
2006: Ruben Claudio Aguilar; Silvia A Longhi; Jonathan D Shaw; Lan-Yu Yeh; Sean Kim; Arne Schön; Ernesto Freire; Ariel Hsu; William K McCormick; Hadiya A Watson; Beverly Wendland
Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4116-21.
2006: Adrian Velazquez-Campoy; Ernesto Freire
Isothermal titration calorimetry to determine association constants for high-affinity ligands.
Nature protocols 2006;1(1):186-91.
2006: Adam J Ruben; Yoshiaki Kiso; Ernesto Freire
Overcoming roadblocks in lead optimization: a thermodynamic perspective.
Chemical biology & drug design 2006;67(1):2-4.
2005: Teresa Carbonell; Ernesto Freire
Binding thermodynamics of statins to HMG-CoA reductase.
Biochemistry 2005;44(35):11741-8.
2005: Ramachandran Murali; Xin Cheng; Alan Berezov; Xiulian Du; Arne Schön; Ernesto Freire; Xiaowei Xu; Youhai H Chen; Mark I Greene
Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10970-5.
2005: Marie Pancera; Jacob Lebowitz; Arne Schön; Ping Zhu; Ernesto Freire; Peter D Kwong; Kenneth H Roux; Joseph Sodroski; Richard Wyatt
Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: characterization and ligand binding analysis.
Journal of virology 2005;79(15):9954-69.
2005: Hiroyasu Ohtaka; Ernesto Freire
Adaptive inhibitors of the HIV-1 protease.
Progress in biophysics and molecular biology 2005;88(2):193-208.
2005: Adrián Velázquez-Campoy; Ernesto Freire
ITC in the post-genomic era...? Priceless.
Biophysical chemistry 2005;115(2-3):115-24.
2004: Hamdy M Abdel-Rahman; Tooru Kimura; Koushi Hidaka; Aiko Kiso; Azin Nezami; Ernesto Freire; Yoshio Hayashi; Yoshiaki Kiso
Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases.
Biological chemistry 2004;385(11):1035-9.
2004: Aiko Kiso; Koushi Hidaka; Tooru Kimura; Yoshio Hayashi; Azin Nezami; Ernesto Freire; Yoshiaki Kiso
Search for substrate-based inhibitors fitting the S2' space of malarial aspartic protease plasmepsin II.
Journal of peptide science : an official publication of the European Peptide Society 2004;10(11):641-7.
2004: Adrián Velázquez-Campoy; Hiroyasu Ohtaka; Azin Nezami; Salman Muzammil; Ernesto Freire
Isothermal titration calorimetry.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] 2004;Chapter 17():Unit 17.8.
2004: Hiroyasu Ohtaka; Salman Muzammil; Arne Schön; Adrian Velazquez-Campoy; Sonia Vega; Ernesto Freire
Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets.
The international journal of biochemistry & cell biology 2004;36(9):1787-99.
2004: Sonia Vega; Lin-Woo Kang; Adrian Velazquez-Campoy; Yoshiaki Kiso; Mario Amzel; Ernesto Freire
A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease.
Proteins 2004;55(3):594-602.
2004: Usman Bacha; Jennifer Barrila; Adrian Velazquez-Campoy; Stephanie A Leavitt; Ernesto Freire
Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro.
Biochemistry 2004;43(17):4906-12.
2004: Zhihai Si; Navid Madani; Jason M. Cox; Jason J Chruma; Jeffrey C Klein; Arne Schön; Ngoc Phan; Liping Wang; Alyssa C Biorn; Simon Cocklin; Irwin Chaiken; Ernesto Freire; Amos B Smith; Joseph Sodroski
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):5036-41.
2004: Alyssa C Biorn; Simon Cocklin; Navid Madani; Zhihai Si; Tijana Ivanovic; James Samanen; Donald Van Ryk; Ralph Pantophlet; Dennis R Burton; Ernesto Freire; Joseph Sodroski; Irwin Chaiken
Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.
Biochemistry 2004;43(7):1928-38.
2004: Stephanie A Leavitt; Arne SchOn; Jeffrey C Klein; Uma Manjappara; Irwin Chaiken; Ernesto Freire
Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.
Current protein & peptide science 2004;5(1):1-8.
2004: Adrian Velazquez-Campoy; Stephanie A Leavitt; Ernesto Freire
Characterization of protein-protein interactions by isothermal titration calorimetry.
Methods in molecular biology (Clifton, N.J.) 2004;261():35-54.
2003: Adrian Velazquez-Campoy; Salman Muzammil; Hiroyasu Ohtaka; Arne Schön; Sonia Vega; Ernesto Freire
Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design.
Current drug targets. Infectious disorders 2003;3(4):311-28.
2003: Hiroyasu Ohtaka; Arne Schön; Ernesto Freire
Multidrug resistance to HIV-1 protease inhibition requires cooperative coupling between distal mutations.
Biochemistry 2003;42(46):13659-66.
2003: Arne Schön; Maria del Mar Ingaramo; Ernesto Freire
The binding of HIV-1 protease inhibitors to human serum proteins.
Biophysical chemistry 2003;105(2-3):221-30.
2003: Azin Nezami; Tooru Kimura; Koushi Hidaka; Aiko Kiso; Jun Liu; Yoshiaki Kiso; Daniel E Goldberg; Ernesto Freire
High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.
Biochemistry 2003;42(28):8459-64.
2003: Adrián Velázquez-Campoy; Sonia Vega; Erin Fleming; Usman Bacha; Yasien Sayed; Heini W Dirr; Ernesto Freire
Protease inhibition in African subtypes of HIV-1.
AIDS reviews 2003;5(3):165-71.
2003: Salman Muzammil; Patrick Ross; Ernesto Freire
A major role for a set of non-active site mutations in the development of HIV-1 protease drug resistance.
Biochemistry 2003;42(3):631-8.
2002: Peter D Kwong; Michael Doyle; David J Casper; Claudia Cicala; Stephanie A Leavitt; Shahzad Majeed; Tavis D Steenbeke; Miro Venturi; Irwin Chaiken; Michael Fung; Hermann Katinger; Paul W I H Parren; James Robinson; Donald Van Ryk; Liping Wang; Dennis R Burton; Ernesto Freire; Richard Wyatt; Joseph Sodroski; Wayne A Hendrickson; James Arthos
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Nature 2002;420(6916):678-82.
2002: Azin Nezami; Ernesto Freire
The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors.
International journal for parasitology 2002;32(13):1669-76.
2002: Irene Luque; Ernesto Freire
Structural parameterization of the binding enthalpy of small ligands.
Proteins 2002;49(2):181-90.
2002: Hiroyasu Ohtaka; Adrián Velázquez-Campoy; Dong Xie; Ernesto Freire
Overcoming drug resistance in HIV-1 chemotherapy: the binding thermodynamics of Amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease.
Protein science : a publication of the Protein Society 2002;11(8):1908-16.
2002: Adrian Velazquez-Campoy; Sonia Vega; Ernesto Freire
Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes.
Biochemistry 2002;41(27):8613-9.
2002: Cynthia S Dowd; Stephanie A Leavitt; Gregory Babcock; Alexis P Godillot; Donald Van Ryk; Gabriela Canziani; Joseph Sodroski; Ernesto Freire; Irwin Chaiken
Beta-turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site.
Biochemistry 2002;41(22):7038-46.
2002: Azin Nezami; Irene Luque; Tooru Kimura; Yoshiaki Kiso; Ernesto Freire
Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.
Biochemistry 2002;41(7):2273-80.
2002: Irene Luque; Stephanie A Leavitt; Ernesto Freire
The linkage between protein folding and functional cooperativity: two sides of the same coin?
Annual review of biophysics and biomolecular structure 2002;31():235-56.
2002: Ernesto Freire
Designing drugs against heterogeneous targets.
Nature biotechnology 2002;20(1):15-6.
2001: V Karantza; Ernesto Freire; Evangelos N Moudrianakis
Thermodynamic studies of the core histones: stability of the octamer subunits is not altered by removal of their terminal domains.
Biochemistry 2001;40(43):13114-23.
2001: Stephanie A Leavitt; Ernesto Freire
Direct measurement of protein binding energetics by isothermal titration calorimetry.
Current opinion in structural biology 2001;11(5):560-6.
2001: Adrian Velazquez-Campoy; Yoshiaki Kiso; Ernesto Freire
The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design.
Archives of biochemistry and biophysics 2001;390(2):169-75.
2001: Adrian Velazquez-Campoy; MJ Todd; Sonia Vega; Ernesto Freire
Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6062-7.
2001: Adrian Velazquez-Campoy; Ernesto Freire
Incorporating target heterogeneity in drug design.
Journal of cellular biochemistry. Supplement 2001;Suppl 37():82-8.
2001: Ernesto Freire
The thermodynamic linkage between protein structure, stability, and function.
Methods in molecular biology (Clifton, N.J.) 2001;168():37-68.
2000: Ernesto Freire
Can allosteric regulation be predicted from structure?
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11680-2.
2000: MJ Todd; Irene Luque; Adrián Velázquez-Campoy; Ernesto Freire
Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant.
Biochemistry 2000;39(39):11876-83.
2000: Adrian Velazquez-Campoy; Irene Luque; MJ Todd; M Milutinovich; Yoshiaki Kiso; Ernesto Freire
Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor.
Protein science : a publication of the Protein Society 2000;9(9):1801-9.
2000: Adrian Velazquez-Campoy; MJ Todd; Ernesto Freire
HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity.
Biochemistry 2000;39(9):2201-7.
2000: J A D'Aquino; Ernesto Freire; Mario Amzel
Binding of small organic molecules to macromolecular targets: evaluation of conformational entropy changes.
Proteins 2000;Suppl 4():93-107.
2000: Irene Luque; Ernesto Freire
Structural stability of binding sites: consequences for binding affinity and allosteric effects.
Proteins 2000;Suppl 4():63-71.
1999: Ernesto Freire
The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10118-22.
1999: MJ Todd; Ernesto Freire
The effect of inhibitor binding on the structural stability and cooperativity of the HIV-1 protease.
Proteins 1999;36(2):147-56.
1999: Mourad Sadqi; Salvador Casares; M A Abril; Obdulio López-Mayorga; Francisco Conejero-Lara; Ernesto Freire
The native state conformational ensemble of the SH3 domain from alpha-spectrin.
Biochemistry 1999;38(28):8899-906.
1999: V Kholodenko; Ernesto Freire
A simple method to measure the absolute heat capacity of proteins.
Analytical biochemistry 1999;270(2):336-8.
1998: MJ Todd; N Semo; Ernesto Freire
The structural stability of the HIV-1 protease.
Journal of molecular biology 1998;283(2):475-88.
1998: Vincent J Hilser; David Wesley Dowdy; Terrence G Oas; Ernesto Freire
The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):9903-8.
1998: S J Milstein; HR Leipold; D Sarubbi; A Leone-Bay; G M Mlynek; Joseph R Robinson; M Kasimova; Ernesto Freire
Partially unfolded proteins efficiently penetrate cell membranes--implications for oral drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):259-67.
1998: Irene Luque; MJ Todd; J Gómez; N Semo; Ernesto Freire
Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis.
Biochemistry 1998;37(17):5791-7.
1998: M R Kasimova; S J Milstein; Ernesto Freire
The conformational equilibrium of human growth hormone.
Journal of molecular biology 1998;277(2):409-18.
1998: Irene Luque; Ernesto Freire
Structure-based prediction of binding affinities and molecular design of peptide ligands.
Methods in enzymology 1998;295():100-27.
1998: Ernesto Freire
Statistical thermodynamic linkage between conformational and binding equilibria.
Advances in protein chemistry 1998;51():255-79.
1998: J Gómez; N Semo; Ernesto Freire
Structural thermodynamic study of the binding of renin inhibitors to endothiapepsin.
Advances in experimental medicine and biology 1998;436():325-8.
1998: Irene Luque; J Gómez; N Semo; Ernesto Freire
Structure-based thermodynamic design of peptide ligands: application to peptide inhibitors of the aspartic protease endothiapepsin.
Proteins 1998;30(1):74-85.
1997: O Boudker; MJ Todd; Ernesto Freire
The structural stability of the co-chaperonin GroES.
Journal of molecular biology 1997;272(5):770-9.
1997: J S Bardi; Irene Luque; Ernesto Freire
Structure-based thermodynamic analysis of HIV-1 protease inhibitors.
Biochemistry 1997;36(22):6588-96.
1997: Vincent J Hilser; B D Townsend; Ernesto Freire
Structure-based statistical thermodynamic analysis of T4 lysozyme mutants: structural mapping of cooperative interactions.
Biophysical chemistry 1997;64(1-3):69-79.
1997: Vincent J Hilser; Ernesto Freire
Predicting the equilibrium protein folding pathway: structure-based analysis of staphylococcal nuclease.
Proteins 1997;27(2):171-83.
1996: Irene Luque; O L Mayorga; Ernesto Freire
Structure-based thermodynamic scale of alpha-helix propensities in amino acids.
Biochemistry 1996;35(42):13681-8.
1996: Vincent J Hilser; Ernesto Freire
Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.
Journal of molecular biology 1996;262(5):756-72.
1996: Vincent J Hilser; J Gómez; Ernesto Freire
The enthalpy change in protein folding and binding: refinement of parameters for structure-based calculations.
Proteins 1996;26(2):123-33.
1996: J A D'Aquino; J Gómez; Vincent J Hilser; K H Lee; Mario Amzel; Ernesto Freire
The magnitude of the backbone conformational entropy change in protein folding.
Proteins 1996;25(2):143-56.
1996: C R Johnson; Mauro Angeletti; Stefania Pucciarelli; Ernesto Freire
Oxygen binding to fallow-deer (Dama dama) hemoglobin: stepwise enthalpies at pH 7.4.
Biophysical chemistry 1996;59(1-2):107-17.
1996: V Karantza; Ernesto Freire; E N Moudrianakis
Thermodynamic studies of the core histones: pH and ionic strength effects on the stability of the (H3-H4)/(H3-H4)2 system.
Biochemistry 1996;35(6):2037-46.
1995: G Privalov; V Kavina; Ernesto Freire; P L Privalov
Precise scanning calorimeter for studying thermal properties of biological macromolecules in dilute solution.
Analytical biochemistry 1995;232(1):79-85.
1995: Izaskun Echabe; T Haltia; Ernesto Freire; Félix M Goñi; José L R Arrondo
Subunit III of cytochrome c oxidase influences the conformation of subunits I and II: an infrared study.
Biochemistry 1995;34(41):13565-9.
1995: YV Griko; Ernesto Freire; G Privalov; H van Dael; Peter L Privalov
The unfolding thermodynamics of c-type lysozymes: a calorimetric study of the heat denaturation of equine lysozyme.
Journal of molecular biology 1995;252(4):447-59.
1995: J Gómez; Ernesto Freire
Thermodynamic mapping of the inhibitor site of the aspartic protease endothiapepsin.
Journal of molecular biology 1995;252(3):337-50.
1995: K T Kenar; B García-Moreno; Ernesto Freire
A calorimetric characterization of the salt dependence of the stability of the GCN4 leucine zipper.
Protein science : a publication of the Protein Society 1995;4(9):1934-8.
1995: J Gómez; Vincent J Hilser; D Xie; Ernesto Freire
The heat capacity of proteins.
Proteins 1995;22(4):404-12.
1995: T Haltia; Ernesto Freire
Forces and factors that contribute to the structural stability of membrane proteins.
Biochimica et biophysica acta 1995;1241(2):295-322.
1995: V Karantza; Andreas D Baxevanis; Ernesto Freire; E N Moudrianakis
Thermodynamic studies of the core histones: ionic strength and pH dependence of H2A-H2B dimer stability.
Biochemistry 1995;34(17):5988-96.
1995: C R Johnson; P E Morin; Cheryl H Arrowsmith; Ernesto Freire
Thermodynamic analysis of the structural stability of the tetrameric oligomerization domain of p53 tumor suppressor.
Biochemistry 1995;34(16):5309-16.
1995: T Haltia; Ernesto Freire
Forces and factors that contribute to the structural stability of membrane proteins.
Biochimica et biophysica acta 1995;1228(1):1-27.
1995: M J Todd; O Boudkin; Ernesto Freire; G H Lorimer
GroES and the chaperonin-assisted protein folding cycle: GroES has no affinity for nucleotides.
FEBS letters 1995;359(2-3):123-5.
1995: K P Murphy; Ernesto Freire; Yvonne Paterson
Configurational effects in antibody-antigen interactions studied by microcalorimetry.
Proteins 1995;21(2):83-90.
1995: Vincent J Hilser; Ernesto Freire
Quantitative analysis of conformational equilibrium using capillary electrophoresis: applications to protein folding.
Analytical biochemistry 1995;224(2):465-85.
1995: K P Murphy; Ernesto Freire
Thermodynamic strategies for rational protein and drug design.
Pharmaceutical biotechnology 1995;7():219-41.
1995: Ernesto Freire
Thermal denaturation methods in the study of protein folding.
Methods in enzymology 1995;259():144-68.
1995: Ernesto Freire
Thermodynamics of partly folded intermediates in proteins.
Annual review of biophysics and biomolecular structure 1995;24():141-65.
1995: Ernesto Freire
Differential scanning calorimetry.
Methods in molecular biology (Clifton, N.J.) 1995;40():191-218.
1994: D Xie; R Fox; Ernesto Freire
Thermodynamic characterization of an equilibrium folding intermediate of staphylococcal nuclease.
Protein science : a publication of the Protein Society 1994;3(12):2175-84.
1994: D Xie; Ernesto Freire
Structure based prediction of protein folding intermediates.
Journal of molecular biology 1994;242(1):62-80.
1994: K H Lee; D Xie; Ernesto Freire; Mario Amzel
Estimation of changes in side chain configurational entropy in binding and folding: general methods and application to helix formation.
Proteins 1994;20(1):68-84.
1994: T Haltia; N Semo; José L R Arrondo; Félix M Goñi; Ernesto Freire
Thermodynamic and structural stability of cytochrome c oxidase from Paracoccus denitrificans.
Biochemistry 1994;33(32):9731-40.
1994: D Xie; Ernesto Freire
Molecular basis of cooperativity in protein folding. V. Thermodynamic and structural conditions for the stabilization of compact denatured states.
Proteins 1994;19(4):291-301.
1994: Ernesto Freire; D Xie
Thermodynamic prediction of structural determinants of the molten globule state of barnase.
Biophysical chemistry 1994;51(2-3):243-51.
1994: YV Griko; Ernesto Freire; Peter L Privalov
Energetics of the alpha-lactalbumin states: a calorimetric and statistical thermodynamic study.
Biochemistry 1994;33(7):1889-99.
1994: D T Haynie; Ernesto Freire
Thermodynamic strategies for stabilizing intermediate states of proteins.
Biopolymers 1994;34(2):261-72.
1994: K P Murphy; D Xie; K S Thompson; Mario Amzel; Ernesto Freire
Entropy in biological binding processes: estimation of translational entropy loss.
Proteins 1994;18(1):63-7.
1994: D T Haynie; Ernesto Freire
Estimation of the folding/unfolding energetics of marginally stable proteins using differential scanning calorimetry.
Analytical biochemistry 1994;216(1):33-41.
1994: Ernesto Freire
Statistical thermodynamic analysis of differential scanning calorimetry data: structural deconvolution of heat capacity function of proteins.
Methods in enzymology 1994;240():502-30.
1993: Z Y Wang; Ernesto Freire; Richard E McCarty
Influence of nucleotide binding site occupancy on the thermal stability of the F1 portion of the chloroplast ATP synthase.
The Journal of biological chemistry 1993;268(28):20785-90.
1993: Ernesto Freire; D T Haynie; D Xie
Molecular basis of cooperativity in protein folding. IV. CORE: a general cooperative folding model.
Proteins 1993;17(2):111-23.
1993: D Montgomery; Robert Jordan; ROGER MCMACKEN; Ernesto Freire
Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli molecular chaperone DnaK.
Journal of molecular biology 1993;232(2):680-92.
1993: D Xie; V Bhakuni; Ernesto Freire
Are the molten globule and the unfolded states of apo-alpha-lactalbumin enthalpically equivalent?
Journal of molecular biology 1993;232(1):5-8.
1993: Ernesto Freire
Structural thermodynamics: prediction of protein stability and protein binding affinities.
Archives of biochemistry and biophysics 1993;303(2):181-4.
1993: K S Thompson; C R Vinson; Ernesto Freire
Thermodynamic characterization of the structural stability of the coiled-coil region of the bZIP transcription factor GCN4.
Biochemistry 1993;32(21):5491-6.
1993: D T Haynie; Ernesto Freire
Structural energetics of the molten globule state.
Proteins 1993;16(2):115-40.
1993: K P Murphy; D Xie; K C Garcia; Mario Amzel; Ernesto Freire
Structural energetics of peptide recognition: angiotensin II/antibody binding.
Proteins 1993;15(2):113-20.
1993: Vincent J Hilser; G D Worosila; Ernesto Freire
Analysis of thermally induced protein folding/unfolding transitions using free solution capillary electrophoresis.
Analytical biochemistry 1993;208(1):125-31.
1992: G Bains; Reiko T Lee; Yuan C Lee; Ernesto Freire
Microcalorimetric study of wheat germ agglutinin binding to N-acetylglucosamine and its oligomers.
Biochemistry 1992;31(50):12624-8.
1992: I M Plaza del Pino; C Nick Pace; Ernesto Freire
Temperature and guanidine hydrochloride dependence of the structural stability of ribonuclease T1.
Biochemistry 1992;31(45):11196-202.
1992: L Fu; Ernesto Freire
On the origin of the enthalpy and entropy convergence temperatures in protein folding.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9335-8.
1992: K P Murphy; V Bhakuni; D Xie; Ernesto Freire
Molecular basis of co-operativity in protein folding. III. Structural identification of cooperative folding units and folding intermediates.
Journal of molecular biology 1992;227(1):293-306.
1992: M Straume; Ernesto Freire
Two-dimensional differential scanning calorimetry: simultaneous resolution of intrinsic protein structural energetics and ligand binding interactions by global linkage analysis.
Analytical biochemistry 1992;203(2):259-68.
1992: Massimo Masserini; Ernesto Freire; Paola Palestini; E Calappi; Guido Tettamanti
Fuc-GM1 ganglioside mimics the receptor function of GM1 for cholera toxin.
Biochemistry 1992;31(8):2422-6.
1992: Ernesto Freire; K P Murphy; Jose M Sanchez-Ruiz; M L Galisteo; Peter L Privalov
The molecular basis of cooperativity in protein folding. Thermodynamic dissection of interdomain interactions in phosphoglycerate kinase.
Biochemistry 1992;31(1):250-6.
1992: K P Murphy; Ernesto Freire
Thermodynamics of structural stability and cooperative folding behavior in proteins.
Advances in protein chemistry 1992;43():313-61.
1992: Kenneth J Breslauer; Ernesto Freire; M Straume
Calorimetry: a tool for DNA and ligand-DNA studies.
Methods in enzymology 1992;211():533-67.
1991: Ernesto Freire; K P Murphy
Molecular basis of co-operativity in protein folding.
Journal of molecular biology 1991;222(3):687-98.
1991: D Xie; V Bhakuni; Ernesto Freire
Calorimetric determination of the energetics of the molten globule intermediate in protein folding: apo-alpha-lactalbumin.
Biochemistry 1991;30(44):10673-8.
1991: C LiCalsi; T S Crocenzi; Ernesto Freire; Saul Roseman
Sugar transport by the bacterial phosphotransferase system. Structural and thermodynamic domains of enzyme I of Salmonella typhimurium.
The Journal of biological chemistry 1991;266(29):19519-27.
1991: P E Morin; Ernesto Freire
Direct calorimetric analysis of the enzymatic activity of yeast cytochrome c oxidase.
Biochemistry 1991;30(34):8494-500.
1991: V Bhakuni; D Xie; Ernesto Freire
Thermodynamic identification of stable folding intermediates in the B-subunit of cholera toxin.
Biochemistry 1991;30(20):5055-60.
1991: G Bains; Ernesto Freire
Calorimetric determination of cooperative interactions in high affinity binding processes.
Analytical biochemistry 1991;192(1):203-6.
1991: W W van Osdol; O L Mayorga; Ernesto Freire
Multifrequency calorimetry of the folding/unfolding transition of cytochrome c.
Biophysical journal 1991;59(1):48-54.
1990: G Ramsay; Ernesto Freire
Linked thermal and solute perturbation analysis of cooperative domain interactions in proteins. Structural stability of diphtheria toxin.
Biochemistry 1990;29(37):8677-83.
1990: P E Morin; D Diggs; Ernesto Freire
Thermal stability of membrane-reconstituted yeast cytochrome c oxidase.
Biochemistry 1990;29(3):781-8.
1990: Ernesto Freire; W W van Osdol; O L Mayorga; Jose M Sanchez-Ruiz
Calorimetrically determined dynamics of complex unfolding transitions in proteins.
Annual review of biophysics and biophysical chemistry 1990;19():159-88.
1989: G C Na; L J Phillips; Ernesto Freire
In vitro collagen fibril assembly: thermodynamic studies.
Biochemistry 1989;28(18):7153-61.
1989: T D Bradrick; Ernesto Freire; Solon Georghiou
A high-sensitivity differential scanning calorimetric study of the interaction of melittin with dipalmitoylphosphatidylcholine fused unilamellar vesicles.
Biochimica et biophysica acta 1989;982(1):94-102.
1989: Massimo Masserini; Paola Palestini; Ernesto Freire
Influence of glycolipid oligosaccharide and long-chain base composition on the thermotropic properties of dipalmitoylphosphatidylcholine large unilamellar vesicles containing gangliosides.
Biochemistry 1989;28(12):5029-34.
1989: A Schön; Ernesto Freire
Thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside GM1.
Biochemistry 1989;28(12):5019-24.
1989: G Ramsay; D Montgomery; D Berger; Ernesto Freire
Energetics of diphtheria toxin membrane insertion and translocation: calorimetric characterization of the acid pH induced transition.
Biochemistry 1989;28(2):529-33.
1988: O L Mayorga; W W van Osdol; J L Lacomba; Ernesto Freire
Frequency spectrum of enthalpy fluctuations associated with macromolecular transitions.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9514-8.
1988: R S Stearman; Alan D Frankel; Ernesto Freire; B S Liu; Carl O Pabo
Combining thermostable mutations increases the stability of lambda repressor.
Biochemistry 1988;27(19):7571-4.
1988: David Shortle; Alan K Meeker; Ernesto Freire
Stability mutants of staphylococcal nuclease: large compensating enthalpy-entropy changes for the reversible denaturation reaction.
Biochemistry 1988;27(13):4761-8.
1988: Beth Goins; Ernesto Freire
Thermal stability and intersubunit interactions of cholera toxin in solution and in association with its cell-surface receptor ganglioside GM1.
Biochemistry 1988;27(6):2046-52.
1987: M Myers; O L Mayorga; J Emtage; Ernesto Freire
Thermodynamic characterization of interactions between ornithine transcarbamylase leader peptide and phospholipid bilayer membranes.
Biochemistry 1987;26(14):4309-15.
1987: C W Rigell; Ernesto Freire
Differential detergent solubility investigation of thermally induced transitions in cytochrome c oxidase.
Biochemistry 1987;26(14):4366-71.
1987: O Lopez Mayorga; Ernesto Freire
Dynamic analysis of differential scanning calorimetry data.
Biophysical chemistry 1987;27(1):87-96.
1987: Y S Tsao; Ernesto Freire; L Huang
Thermodynamic and phase characterization of phosphatidylethanolamine and ganglioside GD1a mixtures.
Biochimica et biophysica acta 1987;900(1):79-87.
1987: M Masserini; Ernesto Freire
Kinetics of ganglioside transfer between liposomal and synaptosomal membranes.
Biochemistry 1987;26(1):237-42.
1986: G Ramsay; R Prabhu; Ernesto Freire
Direct measurement of the energetics of association between myelin basic protein and phosphatidylserine vesicles.
Biochemistry 1986;25(8):2265-70.
1986: Beth Goins; M Masserini; B G Barisas; Ernesto Freire
Lateral diffusion of ganglioside GM1 in phospholipid bilayer membranes.
Biophysical journal 1986;49(4):849-56.
1986: M Masserini; Ernesto Freire
Thermotropic characterization of phosphatidylcholine vesicles containing ganglioside GM1 with homogeneous ceramide chain length.
Biochemistry 1986;25(5):1043-9.
1985: C W Rigell; C de Saussure; Ernesto Freire
Protein and lipid structural transitions in cytochrome c oxidase-dimyristoylphosphatidylcholine reconstitutions.
Biochemistry 1985;24(20):5638-46.
1985: M Myers; Ernesto Freire
Calorimetric and fluorescence characterization of interactions between enkephalins and liposomal and synaptic plasma membranes containing gangliosides.
Biochemistry 1985;24(15):4076-82.
1985: Beth Goins; Ernesto Freire
Lipid phase separations induced by the association of cholera toxin to phospholipid membranes containing ganglioside GM1.
Biochemistry 1985;24(7):1791-7.
1984: B Babbitt; L Huang; Ernesto Freire
Thermotropic and dynamic characterization of interactions of acylated alpha-bungarotoxin with phospholipid bilayer membranes.
Biochemistry 1984;23(17):3920-6.
1984: M Myers; C Wortman; Ernesto Freire
Modulation of neuraminidase activity by the physical state of phospholipid bilayers containing gangliosides Gd1a and Gt1b.
Biochemistry 1984;23(7):1442-8.
1983: Ernesto Freire; T Markello; C Rigell; P W Holloway
Calorimetric and fluorescence characterization of interactions between cytochrome b5 and phosphatidylcholine bilayers.
Biochemistry 1983;22(7):1675-80.
1982: B Snyder; Ernesto Freire
Fluorescence energy transfer in two dimensions. A numeric solution for random and nonrandom distributions.
Biophysical journal 1982;40(2):137-48.
1982: Ernesto Freire; B Snyder
Quantitative characterization of the lateral distribution of membrane proteins within the lipid bilayer.
Biophysical journal 1982;37(3):617-24.
1981: T N Estep; Ernesto Freire; F Anthony; Y Barenholz; R L Biltonen; T E Thompson
Thermal behavior of stearoylsphingomyelin-cholesterol dispersions.
Biochemistry 1981;20(25):7115-8.
1981: F H Anthony; R L Biltonen; Ernesto Freire
Modification of a vibrating-tube density meter for precise temperature scanning.
Analytical biochemistry 1981;116(1):161-7.
1981: Dov Lichtenberg; Ernesto Freire; C F Schmidt; Y Barenholz; P L Felgner; TE Thompson
Effect of surface curvature on stability, thermodynamic behavior, and osmotic activity of dipalmitoylphosphatidylcholine single lamellar vesicles.
Biochemistry 1981;20(12):3462-7.
1981: P L Felgner; Ernesto Freire; Y Barenholz; T E Thompson
Asymmetric incorporation of trisialoganglioside into dipalmitoylphosphatidylcholine vesicles.
Biochemistry 1981;20(8):2168-72.
1980: Ernesto Freire; D Bach; M Correa-Freire; I Miller; Y Barenholz
Calorimetric investigation of the complex phase behavior of glucocerebroside dispersions.
Biochemistry 1980;19(16):3662-5.
1980: B Snyder; Ernesto Freire
Compositional domain structure in phosphatidylcholine--cholesterol and sphingomyelin--cholesterol bilayers.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):4055-9.
1980: Ernesto Freire; B Snyder
Estimation of the lateral distribution of molecules in two-component lipid bilayers.
Biochemistry 1980;19(1):88-94.
1980: B H Robinson; W G Sherwood; S Mayes; Ernesto Freire; J Oei; D DiBattista
Factors affecting glucose turnover and utilization in the neonatal subhuman primate (Macaca mulatta).
Biology of the neonate 1980;37(1-2):60-6.
1979: M C Correa-Freire; Ernesto Freire; Y Barenholz; R L Biltonen; T E Thompson
Thermotropic behavior of monoglucocerebroside--dipalmitoylphosphatidylcholine multilamellar liposomes.
Biochemistry 1979;18(3):442-5.
1978: Ernesto Freire; R Biltonen
Estimation of molecular averages and equilibrium fluctuations in lipid bilayer systems from the excess heat capacity function.
Biochimica et biophysica acta 1978;514(1):54-68.
1978: Barry R Lentz; Ernesto Freire; R L Biltonen
Fluorescence and calorimetric studies of phase transitions in phosphatidylcholine multilayers: kinetics of the pretransition.
Biochemistry 1978;17(21):4475-80.
1978: Ernesto Freire; R L Biltonen
Thermodynamics of transfer ribonucleic acids: the effect of sodium on the thermal unfolding of yeast tRNAPhe.
Biopolymers 1978;17(5):1257-72.
1978: R L Biltonen; Ernesto Freire
Thermodynamic characterization of conformational states of biological macromolecules using differential scanning calorimetry.
CRC critical reviews in biochemistry 1978;5(2):85-124.
1977: J Suurkuusk; J Alvarez; Ernesto Freire; R Biltonen
Calorimetric determination of the heat capacity changes associated with the conformational transitions of polyriboadenylic acid and polyribouridylic acid.
Biopolymers 1977;16(12):2641-52.