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Michael Freitas

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TOP 3
Flavia Pichiorri; Claudia Piovan; Alberto Rocci; Charles L Shapiro; Tiffany Talabere; Stefano Volinia; Jia You; Veronica Balatti; John C Byrd; Luciano Cascione; Jessica Consiglio; Vincenzo Coppola; Luciana De Luca; Michael A Freitas; Pierluigi Gasparini; Jingwen Guan; Craig C Hofmeister; Alessandro Lagana; Guido Marcucci; Gerard Nuovo; Dario Palmieri; Carlo M Croce
In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.
John P Shapiro; Cenny Taslim; Sabyasachi Biswas; Shili Lin; Anand S Merchant; Brad H Rovin; Sashwati Roy; Anjali Satoskar; Chandan K Sen; Michael A Freitas
A quantitative proteomic workflow for characterization of frozen clinical biopsies: laser capture microdissection coupled with label-free mass spectrometry.
Anjali A Satoskar; John P Shapiro; Huijuan Song; Daniel J Birmingham; Cherri N Bott; Sergey V Brodsky; Michael A Freitas; Lee A Hebert; Gyongyi Nadasdy; Tibor Nadasdy; Brad H Rovin
Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli.

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All Publications

2013: Flavia Pichiorri; Claudia Piovan; Alberto Rocci; Charles L Shapiro; Tiffany Talabere; Stefano Volinia; Jia You; Veronica Balatti; John C Byrd; Luciano Cascione; Jessica Consiglio; Vincenzo Coppola; Luciana De Luca; Michael A Freitas; Pierluigi Gasparini; Jingwen Guan; Craig C Hofmeister; Alessandro Lagana; Guido Marcucci; Gerard Nuovo; Dario Palmieri; Carlo M Croce
In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.
The Journal of experimental medicine 2013;210(5):951-68.
2012: John P Shapiro; Cenny Taslim; Sabyasachi Biswas; Shili Lin; Anand S Merchant; Brad H Rovin; Sashwati Roy; Anjali Satoskar; Chandan K Sen; Michael A Freitas
A quantitative proteomic workflow for characterization of frozen clinical biopsies: laser capture microdissection coupled with label-free mass spectrometry.
Journal of proteomics 2012;77():433-40.
2012: Anjali A Satoskar; John P Shapiro; Huijuan Song; Daniel J Birmingham; Cherri N Bott; Sergey V Brodsky; Michael A Freitas; Lee A Hebert; Gyongyi Nadasdy; Tibor Nadasdy; Brad H Rovin
Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2012;25(5):709-21.
2012: Eric K Johnson; Alistair Phillips; Liwen Zhang; Marvin Adams; Michael A Freitas; Stanley C Froehner; Kari B Green-Church; Federica Montanaro
Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins.
PloS one 2012;7(8):e43515.
2011: Jia You; John C Byrd; David M Lucas; Susan V Olesik; Matthew D Ringel; Motoyasu Saji; Liwen Wang; Michael A Freitas
High-sensitivity TFA-free LC-MS for profiling histones.
Proteomics 2011;11(16):3326-34.
2010: Liwen Wang; Sean W Harshman; Shujun Liu; Chen Ren; Hua Xu; Larry Sallans; Michael Grever; John C Byrd; Guido Marcucci; Michael A Freitas
Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.
Proteomics 2010;10(23):4281-92.
2010: David M Lucas; Lapo Alinari; Derek A West; Melanie E Davis; Ryan B Edwards; Amy J Johnson; Kristie A Blum; Craig C Hofmeister; Michael A Freitas; Mark R Parthun; Dasheng Wang; Amy Lehman; Xiaoli Zhang; David Jarjoura; Samuel K Kulp; Carlo M Croce; Michael R Grever; Ching-Shih Chen; Robert A Baiocchi; John C Byrd
The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.
PloS one 2010;5(6):e10941.
2010: Lanhao Yang; Shengjiang Tu; Chen Ren; Esther M M Bulloch; Chung-Lin Liao; Ming-Daw Tsai; Michael A Freitas
Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy.
Analytical biochemistry 2010;396(1):13-22.
2009: Xiaodan Su; Naduparambil K Jacob; Ravindra Amunugama; Pang-Hung Hsu; Richard Fishel; Michael A Freitas
Enrichment and characterization of histones by two-dimensional hydroxyapatite/reversed-phase liquid chromatography-mass spectrometry.
Analytical biochemistry 2009;388(1):47-55.
2009: Hua Xu; Liwen Wang; Larry Sallans; Michael A Freitas
A hierarchical MS2/MS3 database search algorithm for automated analysis of phosphopeptide tandem mass spectra.
Proteomics 2009;9(7):1763-70.
2009: Xiaodan Su; David M Lucas; Liwen Zhang; Hua Xu; Vlad Zabrouskov; Melanie E Davis; Amy R Knapp; Donn C Young; Philip R O Payne; Mark R Parthun; Guido Marcucci; Michael R Grever; John C Byrd; Michael A Freitas
Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia.
Proteomics 2009;9(5):1197-206.
2009: Hua Xu; Michael A Freitas
MassMatrix: a database search program for rapid characterization of proteins and peptides from tandem mass spectrometry data.
Proteomics 2009;9(6):1548-55.
2008: Liwen Zhang; Hua Xu; Chwen-Lih Chen; Kari B Green-Church; Michael A Freitas; Yeong-Renn Chen
Mass spectrometry profiles superoxide-induced intramolecular disulfide in the FMN-binding subunit of mitochondrial Complex I.
Journal of the American Society for Mass Spectrometry 2008;19(12):1875-86.
2008: Hua Xu; Lanhao Yang; Michael A Freitas
A robust linear regression based algorithm for automated evaluation of peptide identifications from shotgun proteomics by use of reversed-phase liquid chromatography retention time.
BMC bioinformatics 2008;9():347.
2008: Hua Xu; Liwen Zhang; Michael A Freitas
Identification and characterization of disulfide bonds in proteins and peptides from tandem MS data by use of the MassMatrix MS/MS search engine.
Journal of proteome research 2008;7(1):138-44.
2007: Shengjiang Tu; Esther M M Bulloch; Lanhao Yang; Chen Ren; Wei-Chieh Huang; Pang-Hung Hsu; Chein-Hung Chen; Chung-Lin Liao; Hui-Ming Yu; Wan-Sheng Lo; Michael A Freitas; Ming-Daw Tsai
Identification of histone demethylases in Saccharomyces cerevisiae.
The Journal of biological chemistry 2007;282(19):14262-71.
2007: Xiaodan Su; Naduparambil K Jacob; Ravindra Amunugama; David M Lucas; Amy R Knapp; Chen Ren; Melanie E Davis; Guido Marcucci; Mark R Parthun; John C Byrd; Richard Fishel; Michael A Freitas
Liquid chromatography mass spectrometry profiling of histones.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;850(1-2):440-54.
2007: Xiaodan Su; Liwen Zhang; David M Lucas; Melanie E Davis; Amy R Knapp; Kari B Green-Church; Guido Marcucci; Mark R Parthun; John C Byrd; Michael A Freitas
Histone H4 acetylation dynamics determined by stable isotope labeling with amino acids in cell culture and mass spectrometry.
Analytical biochemistry 2007;363(1):22-34.
2007: Amy R Knapp; Chen Ren; Xiaodan Su; David M Lucas; John C Byrd; Michael A Freitas; Mark R Parthun
Quantitative profiling of histone post-translational modifications by stable isotope labeling.
Methods (San Diego, Calif.) 2007;41(3):312-9.
2007: Chen Ren; Shujun Liu; Kalpana Ghoshal; Pang-Hung Hsu; Samson T Jacob; Guido Marcucci; Michael A Freitas
Simultaneous metabolic labeling of cells with multiple amino acids: Localization and dynamics of histone acetylation and methylation.
Proteomics. Clinical applications 2007;1(1):130-42.
2007: Hua Xu; Michael A Freitas
A mass accuracy sensitive probability based scoring algorithm for database searching of tandem mass spectrometry data.
BMC bioinformatics 2007;8():133.
2007: Liwen Zhang; Xiaodan Su; Shujun Liu; Amy R Knapp; Mark R Parthun; Guido Marcucci; Michael A Freitas
Histone H4 N-terminal acetylation in Kasumi-1 cells treated with depsipeptide determined by acetic acid-urea polyacrylamide gel electrophoresis, amino acid coded mass tagging, and mass spectrometry.
Journal of proteome research 2007;6(1):81-8.
2005: Chen Ren; Liwen Zhang; Michael A Freitas; Kalpana Ghoshal; Mark R Parthun; Samson T Jacob
Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors.
Journal of the American Society for Mass Spectrometry 2005;16(10):1641-53.
2005: Jianxin Ye; Xi Ai; Ericka E Eugeni; Liwen Zhang; Laura Rocco Carpenter; Mary A Jelinek; Michael A Freitas; Mark R Parthun
Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly.
Molecular cell 2005;18(1):123-30.
2004: Michael A Freitas; Amy R Sklenar; Mark R Parthun
Application of mass spectrometry to the identification and quantification of histone post-translational modifications.
Journal of cellular biochemistry 2004;92(4):691-700.
2004: Liwen Zhang; Michael A Freitas; Joseph Wickham; Mark R Parthun; Marko I Klisovic; Guido Marcucci; John C Byrd
Differential expression of histone post-translational modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry.
Journal of the American Society for Mass Spectrometry 2004;15(1):77-86.
2003: Liwen Zhang; Ericka E Eugeni; Mark R Parthun; Michael A Freitas
Identification of novel histone post-translational modifications by peptide mass fingerprinting.
Chromosoma 2003;112(2):77-86.
2003: Michael A Freitas; Eric King; Stone D-H Shi
Tool command language automation of the modular ion cyclotron data acquisition system (MIDAS) for data-dependent tandem Fourier transform ion cyclotron resonance mass spectrometry.
Rapid communications in mass spectrometry : RCM 2003;17(4):363-70.
2002: Peng Wang; Hua Fu; Donald F Snavley; Michael A Freitas; Dehua Pei
Screening combinatorial libraries by mass spectrometry. 2. Identification of optimal substrates of protein tyrosine phosphatase SHP-1.
Biochemistry 2002;41(19):6202-10.
2002: Elizabeth B Kujawinski; Patrick G Hatcher; Michael A Freitas
High-resolution Fourier transform ion cyclotron resonance mass spectrometry of humic and fulvic acids: improvements and comparisons.
Analytical chemistry 2002;74(2):413-9.
2001: Michael A Freitas; A G Marshall
Gas phase RNA and DNA ions 2. Conformational dependence of the gas-phase H/D exchange of nucleotide-5'-monophosphates.
Journal of the American Society for Mass Spectrometry 2001;12(7):780-5.
2001: Kari B Green-Church; Patrick A Limbach; Michael A Freitas; A G Marshall
Gas-phase hydrogen/deuterium exchange of positively charged mononucleotides by use of Fourier-transform ion cyclotron resonance mass spectrometry.
Journal of the American Society for Mass Spectrometry 2001;12(3):268-77.
2001: Peng Wang; D F Snavley; Michael A Freitas; Dehua Pei
Screening combinatorial libraries for optimal enzyme substrates by mass spectrometry.
Rapid communications in mass spectrometry : RCM 2001;15(14):1166-71.