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Barbara French

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Ronik Khachatoorian; Eden M Maloney; Julie Wang; David Dawson; Barbara A French; Samuel W French; Samuel W French
SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway.
Samuel W French; Jun Li; J Oliva; B Tillman; Fawzia Bardag-Gorce; Barbara A French; A Canaan
FAT10 knock out mice livers fail to develop Mallory-Denk bodies in the DDC mouse model.
Barbara A French; Fawzia Bardag-Gorce; V Buslon; Jun Li; J Oliva; J Zhong; Samuel W French
Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells.

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All Publications

2013: Ronik Khachatoorian; Eden M Maloney; Julie Wang; David Dawson; Barbara A French; Samuel W French; Samuel W French
SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway.
Experimental and molecular pathology 2013;94(1):243-6.
2012: Samuel W French; Jun Li; J Oliva; B Tillman; Fawzia Bardag-Gorce; Barbara A French; A Canaan
FAT10 knock out mice livers fail to develop Mallory-Denk bodies in the DDC mouse model.
Experimental and molecular pathology 2012;93(3):309-14.
2012: Barbara A French; Fawzia Bardag-Gorce; V Buslon; Jun Li; J Oliva; J Zhong; Samuel W French
Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells.
Experimental and molecular pathology 2012;92(3):318-26.
2011: Samuel W French; Jun Li; Fawzia Bardag-Gorce; Barbara A French; J Oliva
The role of innate immunity in the pathogenesis of preneoplasia in drug-induced chronic hepatitis based on a mouse model.
Experimental and molecular pathology 2011;91(3):653-9.
2010: Fawzia Bardag-Gorce; Jun Li; J Oliva; Shelly C Lu; Barbara A French; Samuel W French
The cyclic pattern of blood alcohol levels during continuous ethanol feeding in rats: the effect of feeding S-adenosylmethionine.
Experimental and molecular pathology 2010;88(3):380-7.
2010: Joan Oliva; Barbara A French; X Qing; Samuel W French
The identification of stem cells in human liver diseases and hepatocellular carcinoma.
Experimental and molecular pathology 2010;88(3):331-40.
2010: Jun Li; Joan Oliva; Fawzia Bardag-Gorce; Jennifer Dedes; Barbara A French; Samuel W French
Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changes.
Genes & nutrition 2010;5(2):169-79.
2009: Joan Oliva; Fawzia Bardag-Gorce; Barbara A French; Jun Li; Samuel W French
The regulation of non-coding RNA expression in the liver of mice fed DDC.
Experimental and molecular pathology 2009;87(1):12-9.
2009: Fawzia Bardag-Gorce; Joan Oliva; Jennifer Dedes; Jun Li; Barbara A French; Samuel W French
Chronic ethanol feeding alters hepatocyte memory which is not altered by acute feeding.
Alcoholism, clinical and experimental research 2009;33(4):684-92.
2009: Joan Oliva; Fawzia Bardag-Gorce; Jun Li; Barbara A French; Sheila K Nguyen; Shelly C Lu; Samuel W French
Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms.
Experimental and molecular pathology 2009;86(2):77-86.
2008: Joan Oliva; Barbara A French; Jun Li; Fawzia Bardag-Gorce; Paul Fu; Samuel W French
Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol.
Experimental and molecular pathology 2008;85(3):155-9.
2008: Joan Oliva; Fawzia Bardag-Gorce; Barbara A French; Jun Li; Laron McPhaul; Fataneh Amidi; Jennifer Dedes; Amir Habibi; Sheila Nguyen; Samuel W French
Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis.
Experimental and molecular pathology 2008;84(2):102-12.
2008: Jun Li; Fawzia Bardag-Gorce; Jennifer Dedes; Barbara A French; Fataneh Amidi; Joan Oliva; Samuel W French
S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory.
Hepatology (Baltimore, Md.) 2008;47(2):613-24.
2008: Ilya Gukovsky; Aurelia Lugea; Mohammad Shahsahebi; Jason H Cheng; Peggy P Hong; Yoon J Jung; Quing-gao Deng; Barbara A French; W Lungo; Samuel W French; Hidekazu Tsukamoto; Stephen J Pandol
A rat model reproducing key pathological responses of alcoholic chronic pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G68-79.
2007: Fataneh Amidi; Barbara A French; David Chung; Charles H Halsted; Valentina Medici; Samuel W French
M-30 and 4HNE are sequestered in different aggresomes in the same hepatocytes.
Experimental and molecular pathology 2007;83(3):296-300.
2007: Fawzia Bardag-Gorce; Jennifer Dedes; Barbara A French; Joan V Oliva; Jun Li; Samuel W French
Mallory body formation is associated with epigenetic phenotypic change in hepatocytes in vivo.
Experimental and molecular pathology 2007;83(2):160-8.
2007: Fawzia Bardag-Gorce; Barbara A French; Michael Joyce; Mercedes Baires; Rosalyn O Montgomery; Jun Li; Samuel French
Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels.
Experimental and molecular pathology 2007;82(2):197-202.
2006: Fawzia Bardag-Gorce; Barbara A French; Li Nan; Helen Song; Sheila Khanh Nguyen; Holly Yong; Jennifer Dede; Samuel W French
CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation.
Experimental and molecular pathology 2006;81(3):191-201.
2006: M Waheed Roomi; Karl Gaal; Qi X Yuan; Barbara A French; Paul Fu; Fawzia Bardag-Gorce; Samuel W French
Preneoplastic liver cell foci expansion induced by thioacetamide toxicity in drug-primed mice.
Experimental and molecular pathology 2006;81(1):8-14.
2006: Fawzia Bardag-Gorce; Barbara A French; Jennifer Dedes; Jun Li; Samuel W French
Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared.
Experimental and molecular pathology 2006;80(3):241-51.
2006: Li Nan; Jennifer Dedes; Barbara A French; Fawzia Bardag-Gorce; Jun Li; Yong Wu; Samuel W French
Mallory body (cytokeratin aggresomes) formation is prevented in vitro by p38 inhibitor.
Experimental and molecular pathology 2006;80(3):228-40.
2006: Li Nan; Fawzia Bardag-Gorce; Yong Wu; Jun Li; Barbara A French; Samuel W French
Mallory body forming cells express the preneoplastic hepatocyte phenotype.
Experimental and molecular pathology 2006;80(2):109-18.
2005: Barbara A French; Jennifer Dedes; Fawzia Bardag-Gorce; Jun Li; Latoyia Wilson; Paul Fu; Li Nan; Samuel W French
Microarray analysis of gene expression in the liver during the urinary ethanol cycle in rats fed ethanol intragastrically at a constant rate.
Experimental and molecular pathology 2005;79(2):87-94.
2005: Fawzia Bardag-Gorce; Tricia Francis; Li Nan; Jun Li; Yan He Lue; Barbara A French; Samuel W French
Modifications in P62 occur due to proteasome inhibition in alcoholic liver disease.
Life sciences 2005;77(20):2594-602.
2005: Yong Wu; Li Nan; Fawzia Bardag-Gorce; Jun Li; Barbara A French; La Toyia Wilson; Jennifer Dedes; Samuel W French
The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro study.
Experimental and molecular pathology 2005;79(1):1-8.
2005: Jun Li; Barbara A French; Li Nan; Paul Fu; Samuel W French
Uncoupling of oxidative phosphorylation prevents the urinary alcohol level cycling caused by feeding ethanol continuously at a constant rate.
Experimental and molecular pathology 2005;78(3):228-32.
2005: Fawzia Bardag-Gorce; L Wilson; Li Nan; Jun Li; Barbara A French; Timothy R Morgan; Kengathevy Morgan; Samuel W French
CYP2E1 inhibition enhances mallory body formation.
Experimental and molecular pathology 2005;78(3):207-11.
2005: Li Nan; Yong Wu; Fawzia Bardag-Gorce; Jun Li; Barbara A French; La Toyia Wilson; Samuel W French
The p105/50 NF-kappaB pathway is essential for Mallory body formation.
Experimental and molecular pathology 2005;78(3):198-206.
2005: Fawzia Bardag-Gorce; Jun Li; Barbara A French; Samuel W French
The effect of ethanol-induced CYP2E1 on proteasome activity: the role of 4-hydroxynonenal.
Experimental and molecular pathology 2005;78(2):109-15.
2005: Jun Li; Paul Fu; M Deleon; Barbara A French; Samuel W French
The effect of Viagra (sildenafil citrate) on liver injury caused by chronic ethanol intragastric feeding in rats.
Experimental and molecular pathology 2005;78(2):101-8.
2005: Li Nan; Yong Wu; Fawzia Bardag-Gorce; Jun Li; Barbara A French; La Toyia Wilson; Sheila Khanh Nguyen; Samuel W French
RNA interference of VCP/p97 increases Mallory body formation.
Experimental and molecular pathology 2005;78(1):1-9.
2004: Jun Li; Paul Fu; Barbara A French; Samuel W French
The effect of rotenone on the urinary ethanol cycle in rats fed ethanol intragastrically.
Experimental and molecular pathology 2004;77(3):210-3.
2004: Li Nan; Yong Wu; Fawzia Bardag-Gorce; Jun Li; Barbara A French; Alan N Fu; Tricia Francis; Jennifer Vu; Samuel W French
p62 is involved in the mechanism of Mallory body formation.
Experimental and molecular pathology 2004;77(3):168-75.
2004: Jun Li; Barbara A French; Paul Fu; Fawzia Bardag-Gorce; Samuel W French
Catecholamines are involved in the mechanism of the urinary alcohol level cycle in rats fed ethanol intragastrically at a constant rate.
Life sciences 2004;75(25):3043-51.
2004: Fawzia Bardag-Gorce; Ravi Venkatesh; Jun Li; Barbara A French; Samuel W French
Hyperphosphorylation of rat liver proteasome subunits: the effects of ethanol and okadaic acid are compared.
Life sciences 2004;75(5):585-97.
2004: Fawzia Bardag-Gorce; Nora E Riley; Li Nan; Rosalyn O Montgomery; Jun Li; Barbara A French; Yanhe Lue; Samuel W French
The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation.
Experimental and molecular pathology 2004;76(1):9-16.
2003: Jun Li; Barbara A French; Paul Fu; Fawzia Bardag-Gorce; Samuel W French
Mechanism of the alcohol cyclic pattern: role of catecholamines.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(2):G442-8.
2003: Fawzia Bardag-Gorce; Nora E Riley; Victoria Nguyen; Rosalyn O Montgomery; Barbara A French; Jun Li; Fijs W B van Leeuwen; W Lungo; Laron McPhaul; Samuel W French
The mechanism of cytokeratin aggresome formation: the role of mutant ubiquitin (UBB+1).
Experimental and molecular pathology 2003;74(2):160-7.
2002: Fawzia Bardag-Gorce; Fijs W B van Leeuwen; Victoria Nguyen; Barbara A French; Jun Li; Nora E Riley; Laron McPhaul; Yanhe Lue; Samuel W French
The role of the ubiquitin-proteasome pathway in the formation of mallory bodies.
Experimental and molecular pathology 2002;73(2):75-83.
2002: Fawzia Bardag-Gorce; Barbara A French; Jun Li; Nora E Riley; Qi X Yuan; Vimonrat Valinluck; Paul Fu; Magnus Ingelman-Sundberg; Seokjoo Yoon; Samuel W French
The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats.
Gastroenterology 2002;123(1):325-35.
2002: Fawzia Bardag-Gorce; Jun Li; Barbara A French; Samuel W French
Ethanol withdrawal induced CYP2E1 degradation in vivo, blocked by proteasomal inhibitor PS-341.
Free radical biology & medicine 2002;32(1):17-21.
2001: Barbara A French; F van Leeuwen; Nora E Riley; Qi X Yuan; Fawzia Bardag-Gorce; Karl Gaal; Yanhe Lue; N Marceau; Samuel W French
Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin.
Experimental and molecular pathology 2001;71(3):241-6.
2001: Jun Li; Barbara A French; Nora E Riley; Fawzia Bardag-Gorce; Paul Fu; Samuel W French
Oral low-carbohydrate alcohol liquid diet induces experimental steatohepatitis in the rat.
Experimental and molecular pathology 2001;71(2):132-6.
2001: Jun Li; Barbara A French; Paul Fu; Samuel W French
Liver necrosis induced by thyroid hormone administration in rats fed ethanol.
Experimental and molecular pathology 2001;71(1):79-88.
2001: Fawzia Bardag-Gorce; Barbara A French; Yanhe Lue; Victoria Nguyen; Yu-Jui Yvonne Wan; Samuel W French
Mallory bodies formed in proteasome-depleted hepatocytes: an immunohistochemical study.
Experimental and molecular pathology 2001;70(1):7-18.
2000: Fawzia Bardag-Gorce; Qi X Yuan; Jun Li; Barbara A French; C Fang; Magnus Ingelman-Sundberg; Samuel W French
The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol.
Biochemical and biophysical research communications 2000;279(1):23-9.
2000: Qi X Yuan; Y Nagao; Barbara A French; Yu-Jui Yvonne Wan; Samuel W French
Dexamethasone enhances mallory body formation in drug-primed mouse liver.
Experimental and molecular pathology 2000;69(3):202-10.
2000: Z Gouillon; D Lucas; Jun Li; A L Hagbjork; Barbara A French; Paul Fu; C Fang; Magnus Ingelman-Sundberg; T M Donohue; Samuel W French
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 2000;224(4):302-8.
2000: Jun Li; Victoria Nguyen; Barbara A French; A F Parlow; Grace L Su; Paul Fu; Qi X Yuan; Samuel W French
Mechanism of the alcohol cyclic pattern: role of the hypothalamic-pituitary-thyroid axis.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(1):G118-25.
1999: Z Q Gouillon; K Miyamoto; T M Donohue; Yu-Jui Yvonne Wan; Barbara A French; Y Nagao; Paul Fu; R C Reitz; A Hagbjork; C Yap; Qi X Yuan; Magnus Ingelman-Sundberg; Samuel W French
Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway.
Frontiers in bioscience : a journal and virtual library 1999;4():A16-25.
1998: Y Nagao; Barbara A French; Yan Cai; Samuel W French; Yu-Jui Yvonne Wan
Inhibition of PPAR alpha/RXR alpha-mediated direct hyperplasia pathways during griseofulvin-induced hepatocarcinogenesis.
Journal of cellular biochemistry 1998;69(2):189-200.
1998: Z Q Zhang-Gouillon; Qi X Yuan; B Hu; N Marceau; Barbara A French; Karl Gaal; Y Nagao; Yu-Jui Yvonne Wan; Samuel W French
Mallory body formation by ethanol feeding in drug-primed mice.
Hepatology (Baltimore, Md.) 1998;27(1):116-22.
1996: Qi X Yuan; N Marceau; Barbara A French; P Fu; Samuel W French
Mallory body induction in drug-primed mouse liver.
Hepatology (Baltimore, Md.) 1996;24(3):603-12.
1995: Qi X Yuan; N Marceau; Barbara A French; P Fu; Samuel W French
Heat shock in vivo induces Mallory body formation in drug primed mouse liver.
Experimental and molecular pathology 1995;63(1):63-76.