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Jean-Marie Frère

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TOP 3
Astrid Zervosen; André Zapun; Jean-Marie Frère
Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.
Astrid Zervosen; Eric Sauvage; Paulette Charlier; Jean-Marie Frère; André Luxen
Development of new drugs for an old target: the penicillin binding proteins.
Marylène Vandevenne; Vincent Campisi; Astrid Freichels; Jean-Marie Frère; Moreno Galleni; Gilles Gaspard; Carole Gillard; Patrice Filée
Comparative functional analysis of the human macrophage chitotriosidase.

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All Publications

2013: Astrid Zervosen; André Zapun; Jean-Marie Frère
Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.
Antimicrobial agents and chemotherapy 2013;57(1):661-3.
2012: Astrid Zervosen; Eric Sauvage; Paulette Charlier; Jean-Marie Frère; André Luxen
Development of new drugs for an old target: the penicillin binding proteins.
Molecules (Basel, Switzerland) 2012;17(11):12478-505.
2011: Marylène Vandevenne; Vincent Campisi; Astrid Freichels; Jean-Marie Frère; Moreno Galleni; Gilles Gaspard; Carole Gillard; Patrice Filée
Comparative functional analysis of the human macrophage chitotriosidase.
Protein science : a publication of the Protein Society 2011;20(8):1451-63.
2011: Astrid Zervosen; André Bouillez; Paulette Charlier; Jean-Marie Frère; Alexandre Herman; Raphaël Herman; Bernard Joris; Frédéric Kerff; André Luxen; Fabio Prati; Rex F Pratt; Eric Sauvage
Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin-binding protein.
Journal of the American Chemical Society 2011;133(28):10839-48.
2011: Eduard Dolušić; Pierre Larrieu; Sébastien Blanc; Frédéric Sapunaric; Jenny Pouyez; Laurence Moineaux; Delphine Colette; Vincent Stroobant; Luc Pilotte; Didier Colau; Thierry Ferain; Graeme Fraser; Moreno Galleni; Jean-Marie Frère; Bernard Masereel; Benoît Van den Eynde; Johan Wouters; Raphaël Frédérick
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
European journal of medicinal chemistry 2011;46(7):3058-65.
2011: Adeline Derouaux; Samo Turk; Nick K Olrichs; Stanislav Gobec; Eefjan Breukink; Ana Amoroso; Julien Offant; Julieanne Bostock; Katherine Mariner; Ian Chopra; Thierry Vernet; Astrid Zervosen; Bernard Joris; Jean-Marie Frère; Martine Nguyen-Distèche; Mohammed Terrak
Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor.
Biochemical pharmacology 2011;81(9):1098-105.
2011: Louise E Horsfall; Youssef Izougarhane; Patricia Lassaux; Nathalie Selevsek; Benoit M R Liénard; Laurent Poirel; Michael B Kupper; Kurt M Hoffmann; Jean-Marie Frère; Moreno Galleni; Carine Bebrone
Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme.
The FEBS journal 2011;278(8):1252-63.
2011: Patricia Lassaux; Daouda A K Traoré; Elodie Loisel; Adrien Favier; Jean-Denis Docquier; Jean Sébastien Sohier; Clémentine Laurent; Carine Bebrone; Jean-Marie Frère; Jean-Luc Ferrer; Moreno Galleni
Biochemical and structural characterization of the subclass B1 metallo-β-lactamase VIM-4.
Antimicrobial agents and chemotherapy 2011;55(3):1248-55.
2011: Eduard Dolušić; Pierre Larrieu; Sébastien Blanc; Frédéric Sapunaric; Bernadette Norberg; Laurence Moineaux; Delphine Colette; Vincent Stroobant; Luc Pilotte; Didier Colau; Thierry Ferain; Graeme Fraser; Moreno Galeni; Jean-Marie Frère; Bernard Masereel; Benoît Van den Eynde; Johan Wouters; Moreno Galleni; Raphaël Frédérick
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Bioorganic & medicinal chemistry 2011;19(4):1550-61.
2010: Lionel Vercheval; Cédric Bauvois; Alexandre di Paolo; Franck Borel; Jean-Luc Ferrer; Eric Sauvage; Alain Matagne; Jean-Marie Frère; Paulette Charlier; Moreno Galleni; Frédéric Kerff
Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70.
The Biochemical journal 2010;432(3):495-504.
2010: Frédéric Mercier; Astrid Zervosen; Nathalie Teller; Jean-Marie Frère; Raphaël Herman; Anne Pennartz; Bernard Joris; André Luxen
1,6-AnhMurNAc derivatives for assay development of amidase AmiD.
Bioorganic & medicinal chemistry 2010;18(21):7422-31.
2010: Luisa Borgianni; Julie Vandenameele; Alain Matagne; Luca Bini; Robert A Bonomo; Jean-Marie Frère; Gian Maria Rossolini; Jean-Denis Docquier
Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding.
Antimicrobial agents and chemotherapy 2010;54(8):3197-204.
2010: Patricia Lassaux; Matthieu Hamel; Mihaela Gulea; Heinrich Delbrück; Paola Sandra Mercuri; Louise Horsfall; Dominique Dehareng; Michaël Kupper; Jean-Marie Frère; Kurt Hoffmann; Moreno Galleni; Carine Bebrone
Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases.
Journal of medicinal chemistry 2010;53(13):4862-76.
2010: Julie Vandenameele; Annabelle Lejeune; Alexandre Di Paolo; Alain Brans; Jean-Marie Frère; Franz X Schmid; Alain Matagne
Folding of class A beta-lactamases is rate-limited by peptide bond isomerization and occurs via parallel pathways.
Biochemistry 2010;49(19):4264-75.
2010: Frédéric Kerff; Stephanie Petrella; Frédéric Mercier; Eric Sauvage; Raphaël Herman; Anne Pennartz; Astrid Zervosen; André Luxen; Jean-Marie Frère; Bernard Joris; Paulette Charlier
Specific structural features of the N-acetylmuramoyl-L-alanine amidase AmiD from Escherichia coli and mechanistic implications for enzymes of this family.
Journal of molecular biology 2010;397(1):249-59.
2009: Stéphane Baurin; Lionel Vercheval; Fabrice Bouillenne; Claudia Falzone; Alain Brans; Lilian Jacquamet; Jean-Luc Ferrer; Eric Sauvage; Dominique Dehareng; Jean-Marie Frère; Paulette Charlier; Moreno Galleni; Frédéric Kerff
Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases.
Biochemistry 2009;48(47):11252-63.
2009: Colette Duez; Astrid Zervosen; Nathalie Teller; Rémy Melkonian; Emmanuel Banzubazé; Fabrice Bouillenne; André Luxen; Jean-Marie Frère
Characterization of the proteins encoded by the Bacillus subtilis yoxA-dacC operon.
FEMS microbiology letters 2009;300(1):42-7.
2009: Yves Decrem; Géraldine Rath; Virginie Blasioli; Philippe Cauchie; Séverine Robert; Jérôme Beaufays; Jean-Marie Frère; Olivier Feron; Jean-Michel Dogné; Chantal Dessy; Luc Vanhamme; Edmond Godfroid
Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis.
The Journal of experimental medicine 2009;206(11):2381-95.
2009: Olivier Jacquin; Dorothée Balbeur; Christian Damblon; Pierre Marchot; Edwin De Pauw; Gordon Roberts; Jean-Marie Frère; Alain Matagne
Positively cooperative binding of zinc ions to Bacillus cereus 569/H/9 beta-lactamase II suggests that the binuclear enzyme is the only relevant form for catalysis.
Journal of molecular biology 2009;392(5):1278-91.
2009: Boukaré Zeba; Filomena De Luca; Alain Dubus; Michael Delmarcelle; Jacques Simporé; Odile G Nacoulma; Gian Maria Rossolini; Jean-Marie Frère; Jean-Denis Docquier
IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso.
Antimicrobial agents and chemotherapy 2009;53(10):4320-6.
2009: Carine Bebrone; Heinrich Delbrück; Michaël B Kupper; Philipp Schlömer; Charlotte Willmann; Jean-Marie Frère; Rainer Fischer; Moreno Galleni; Kurt M V Hoffmann
The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site.
Antimicrobial agents and chemotherapy 2009;53(10):4464-71.
2008: marie-eve dumez; Nathalie Teller; Frédéric Mercier; Tetsuya Tanaka; Isabel Vandenberghe; Michel Vandenbranden; Bart Devreese; André Luxen; Jean-Marie Frère; Alain Matagne; Alain Jacquet; Moreno Galleni; Andy Chevigné
Activation mechanism of recombinant Der p 3 allergen zymogen: contribution of cysteine protease Der p 1 and effect of propeptide glycosylation.
The Journal of biological chemistry 2008;283(45):30606-17.
2008: Nadia Ruth; Birgit Quinting; Jacques Mainil; Bernard Hallet; Jean-Marie Frère; Kris Huygen; Moreno Galleni
Creating hybrid proteins by insertion of exogenous peptides into permissive sites of a class A beta-lactamase.
The FEBS journal 2008;275(20):5150-60.
2008: Carine Bebrone; Christine Anne; Frédéric Kerff; Gianpiero Garau; Kris De Vriendt; Raphaël Lantin; Bart Devreese; Jozef Van Beeumen; Otto Dideberg; Jean-Marie Frère; Moreno Galleni
Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila.
The Biochemical journal 2008;414(1):151-9.
2008: Benoît M R Liénard; Gianpiero Garau; Louise Horsfall; Andreas Ioannis Karsisiotis; Christian Damblon; Patricia Lassaux; Cyril Papamicael; Gordon Roberts; Moreno Galleni; Otto Dideberg; Jean-Marie Frère; Christopher J Schofield
Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.
Organic & biomolecular chemistry 2008;6(13):2282-94.
2008: M Vandevenne; G Gaspard; N Yilmaz; Fabrizio Giannotta; Jean-Marie Frère; Moreno Galleni; Patrice Filée
Rapid and easy development of versatile tools to study protein/ligand interactions.
Protein engineering, design & selection : PEDS 2008;21(7):443-51.
2008: Magdalena Stoczko; Jean-Marie Frère; Gian Maria Rossolini; Jean-Denis Docquier
Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora.
Antimicrobial agents and chemotherapy 2008;52(7):2473-9.
2008: Catherine Michaux; Jan Massant; Frédéric Kerff; Jean-Marie Frère; Jean-Denis Docquier; Isabel Vandenberghe; Bart Samyn; Annick Pierrard; Georges Feller; Paulette Charlier; Jozef Van Beeumen; Johan Wouters
Crystal structure of a cold-adapted class C beta-lactamase.
The FEBS journal 2008;275(8):1687-97.
2008: Benoît M R Liénard; Rebekka Hüting; Patricia Lassaux; Moreno Galleni; Jean-Marie Frère; Christopher J Schofield
Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.
Journal of medicinal chemistry 2008;51(3):684-8.
2008: Annabelle Lejeune; RH Pain; Paulette Charlier; Jean-Marie Frère; Alain Matagne
TEM-1 beta-lactamase folds in a nonhierarchical manner with transient non-native interactions involving the C-terminal region.
Biochemistry 2008;47(4):1186-93.
2007: Andy Chevigné; Roya Barumandzadeh; Sylvie Groslambert; Benoît Cloes; Dominique Dehareng; Patrice Filée; Jean-Claude Marx; Jean-Marie Frère; Alain Matagne; Alain Jacquet; Moreno Galleni
Relationship between propeptide pH unfolding and inhibitory ability during ProDer p 1 activation mechanism.
Journal of molecular biology 2007;374(1):170-85.
2007: Marylène Vandevenne; Patrice Filee; Natacha Scarafone; Benoît Cloes; Gilles Gaspard; Nursel Yilmaz; Mireille Dumoulin; Jean-Marie François; Jean-Marie Frère; Moreno Galleni
The Bacillus licheniformis BlaP beta-lactamase as a model protein scaffold to study the insertion of protein fragments.
Protein science : a publication of the Protein Society 2007;16(10):2260-71.
2007: Eric Sauvage; Colette Duez; Raphaël Herman; Frédéric Kerff; Stephanie Petrella; John W Anderson; Suara A Adediran; Rex F Pratt; Jean-Marie Frère; Paulette Charlier
Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide.
Journal of molecular biology 2007;371(2):528-39.
2007: L E Horsfall; Gianpiero Garau; B M R Liénard; Otto Dideberg; C J Schofield; Jean-Marie Frère; Moreno Galleni
Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.
Antimicrobial agents and chemotherapy 2007;51(6):2136-42.
2007: Andy Chevigné; Nursel Yilmaz; Gilles Gaspard; Fabrizio Giannotta; Jean Marie François; Jean-Marie Frère; Moreno Galleni; Patrice Filée
Use of bifunctional hybrid beta-lactamases for epitope mapping and immunoassay development.
Journal of immunological methods 2007;320(1-2):81-93.
2007: Benoît M R Liénard; Louise E Horsfall; Moreno Galleni; Jean-Marie Frère; Christopher J Schofield
Inhibitors of the FEZ-1 metallo-beta-lactamase.
Bioorganic & medicinal chemistry letters 2007;17(4):964-8.
2007: Yoshikazu Ishii; Moreno Galleni; Ling Ma; Jean-Marie Frère; Keizo Yamaguchi
Biochemical characterisation of the CTX-M-14 beta-lactamase.
International journal of antimicrobial agents 2007;29(2):159-64.
2006: Eric Sauvage; Eveline Fonzé; Birgit Quinting; Moreno Galleni; Jean-Marie Frère; Paulette Charlier
Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.
Antimicrobial agents and chemotherapy 2006;50(7):2516-21.
2006: Nathalie Selevsek; Andreas Tholey; Elmar Heinzle; Benoît M R Liénard; Neil J Oldham; Christopher J Schofield; Uwe Heinz; Hans-Werner Adolph; Jean-Marie Frère
Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry.
Journal of the American Society for Mass Spectrometry 2006;17(7):1000-4.
2006: Magdalena Stoczko; Jean-Marie Frère; Gian Maria Rossolini; Jean-Denis Docquier
Postgenomic scan of metallo-beta-lactamase homologues in rhizobacteria: identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum.
Antimicrobial agents and chemotherapy 2006;50(6):1973-81.
2006: Claudine Fraipont; Frédéric Sapunaric; Astrid Zervosen; Geneviève Auger; Bart Devreese; Thierry Lioux; Didier Blanot; Dominique Mengin-Lecreulx; Piet Herdewijn; Jozef Van Beeumen; Jean-Marie Frère; Martine Nguyen-Distèche
Glycosyl transferase activity of the Escherichia coli penicillin-binding protein 1b: specificity profile for the substrate.
Biochemistry 2006;45(12):4007-13.
2006: Joanna Zawadzka-Skomial; Zdzislaw Markiewicz; Martine Nguyen-Distèche; Bart Devreese; Jean-Marie Frère; Mohammed Terrak
Characterization of the bifunctional glycosyltransferase/acyltransferase penicillin-binding protein 4 of Listeria monocytogenes.
Journal of bacteriology 2006;188(5):1875-81.
2006: Kris De Vriendt; Gonzalez Van Driessche; Bart Devreese; Carine Bebrone; Christine Anne; Jean-Marie Frère; Moreno Galleni; Jozef Van Beeumen
Monitoring the zinc affinity of the metallo-beta-lactamase CphA by automated nanoESI-MS.
Journal of the American Society for Mass Spectrometry 2006;17(2):180-8.
2005: Jean-Marie Frère; Pierre Marchot
Inactivators in competition. How to deal with them ... and not!
Biochemical pharmacology 2005;70(10):1417-23.
2005: Noureddine Rhazi; Michaël Delmarcelle; Eric Sauvage; Françoise Jacquemotte; Kris Devriendt; Valérie Tallon; Léon Ghosez; Jean-Marie Frère
Specificity and reversibility of the transpeptidation reaction catalyzed by the Streptomyces R61 D-Ala-D-Ala peptidase.
Protein science : a publication of the Protein Society 2005;14(11):2922-8.
2005: Suara A Adediran; Michiyoshi Nukaga; Stéphane Baurin; Jean-Marie Frère; Rex F Pratt
Inhibition of class D beta-lactamases by acyl phosphates and phosphonates.
Antimicrobial agents and chemotherapy 2005;49(10):4410-2.
2005: Cédric Bauvois; Akiko Shimizu Ibuka; Almeida Celso; Jimena Alba; Yoshikazu Ishii; Jean-Marie Frère; Moreno Galleni
Kinetic properties of four plasmid-mediated AmpC beta-lactamases.
Antimicrobial agents and chemotherapy 2005;49(10):4240-6.
2005: Eric Sauvage; Raphaël Herman; Stephanie Petrella; Colette Duez; Fabrice Bouillenne; Jean-Marie Frère; Paulette Charlier
Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins.
The Journal of biological chemistry 2005;280(35):31249-56.
2005: Michaël Delmarcelle; Marie-Caroline Boursoit; Patrice Filée; Stéphane Lucius Baurin; Jean-Marie Frère; Bernard Joris
Specificity inversion of Ochrobactrum anthropi D-aminopeptidase to a D,D-carboxypeptidase with new penicillin binding activity by directed mutagenesis.
Protein science : a publication of the Protein Society 2005;14(9):2296-303.
2005: Carine Bebrone; Christine Anne; Kris De Vriendt; Bart Devreese; Gian Maria Rossolini; Jozef Van Beeumen; Jean-Marie Frère; Moreno Galleni
Dramatic broadening of the substrate profile of the Aeromonas hydrophila CphA metallo-beta-lactamase by site-directed mutagenesis.
The Journal of biological chemistry 2005;280(31):28195-202.
2005: Antonio Llinas; Naveed Ahmed; Massimiliano Cordaro; Andrew P Laws; Jean-Marie Frère; Michaël Delmarcelle; Nicholas R Silvaggi; Judith A Kelly; Michael I Page
Inactivation of bacterial DD-peptidase by beta-sultams.
Biochemistry 2005;44(21):7738-46.
2005: Nadia Ruth; Jacques Mainil; Virginie Roupie; Jean-Marie Frère; Moreno Galleni; Kris Huygen
DNA vaccination for the priming of neutralizing antibodies against non-immunogenic STa enterotoxin from enterotoxigenic Escherichia coli.
Vaccine 2005;23(27):3618-27.
2005: Frédéric de Lemos Esteves; Thierry Gouders; Josette Lamotte-Brasseur; Sébastien Rigali; Jean-Marie Frère
Improving the alkalophilic performances of the Xyl1 xylanase from Streptomyces sp. S38: structural comparison and mutational analysis.
Protein science : a publication of the Protein Society 2005;14(2):292-302.
2005: Gianpiero Garau; Carine Bebrone; Christine Anne; Moreno Galleni; Jean-Marie Frère; Otto Dideberg
A metallo-beta-lactamase enzyme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem.
Journal of molecular biology 2005;345(4):785-95.
2004: Jean-Denis Docquier; Teresa Lopizzo; Sabrina Liberatori; Manuela Prenna; Maria Thaller; Jean-Marie Frère; Gian Maria Rossolini
Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum.
Antimicrobial agents and chemotherapy 2004;48(12):4778-83.
2004: Christelle Vreuls; Patrice Filée; Hélène Van Melckebeke; Tony Aerts; Peter De Deyn; Gabriel Llabrès; Alain Matagne; Jean-Pierre Simorre; Jean-Marie Frère; Bernard Joris
Guanidinium chloride denaturation of the dimeric Bacillus licheniformis BlaI repressor highlights an independent domain unfolding pathway.
The Biochemical journal 2004;384(Pt 1):179-90.
2004: Laurent Dreesen; Christophe Humbert; Yannick Sartenaer; Y Caudano; Cédric Volcke; Alaa A Mani; André Peremans; Paul A Thiry; Sophie Hanique; Jean-Marie Frère
Electronic and molecular properties of an adsorbed protein monolayer probed by two-color sum-frequency generation spectroscopy.
Langmuir : the ACS journal of surfaces and colloids 2004;20(17):7201-7.
2004: Paola Sandra Mercuri; Isabel García-Sáez; Kris De Vriendt; Iris Thamm; Bart Devreese; Jozef Van Beeumen; Otto Dideberg; Gian Maria Rossolini; Jean-Marie Frère; Moreno Galleni
Probing the specificity of the subclass B3 FEZ-1 metallo-beta-lactamase by site-directed mutagenesis.
The Journal of biological chemistry 2004;279(32):33630-8.
2004: Gianpiero Garau; Isabel García-Sáez; Carine Bebrone; Christine Anne; Paola Sandra Mercuri; Moreno Galleni; Jean-Marie Frère; Otto Dideberg
Update of the standard numbering scheme for class B beta-lactamases.
Antimicrobial agents and chemotherapy 2004;48(7):2347-9.
2004: Frédéric de Lemos Esteves; Virginie Ruelle; Josette Lamotte-Brasseur; Birgit Quinting; Jean-Marie Frère
Acidophilic adaptation of family 11 endo-beta-1,4-xylanases: modeling and mutational analysis.
Protein science : a publication of the Protein Society 2004;13(5):1209-18.
2004: Wing Y Tsang; Anupma Dhanda; Christopher J Schofield; Jean-Marie Frère; Moreno Galleni; Michael I Page
The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives.
Bioorganic & medicinal chemistry letters 2004;14(7):1737-9.
2004: Sophie Hanique; Maria-Luigi Colombo; Erik Goormaghtigh; Patrice Soumillion; Jean-Marie Frère; Bernard Joris
Evidence of an intramolecular interaction between the two domains of the BlaR1 penicillin receptor during the signal transduction.
The Journal of biological chemistry 2004;279(14):14264-72.
2004: Astrid Zervosen; Wei-Ping Lu; Zhouliang Chen; Ronald E White; Thomas Demuth; Jean-Marie Frère
Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones.
Antimicrobial agents and chemotherapy 2004;48(3):961-9.
2004: Bernard Grisart; Frédéric Farnir; Latifa Karim; Nadine Cambisano; Jong-Joo Kim; Angela Kvasz; Myriam Mni; Patricia Simon; Jean-Marie Frère; Wouter Coppieters; Michel Georges
Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2398-403.
2004: Maria-Luigi Colombo; Sophie Hanique; Stéphane L Baurin; Cédric Bauvois; Kris De Vriendt; Jozef J Van Beeumen; Jean-Marie Frère; Bernard Joris
The ybxI gene of Bacillus subtilis 168 encodes a class D beta-lactamase of low activity.
Antimicrobial agents and chemotherapy 2004;48(2):484-90.
2004: Catherine Généreux; Dominique Dehareng; Bart Devreese; Jozef Van Beeumen; Jean-Marie Frère; Bernard Joris
Mutational analysis of the catalytic centre of the Citrobacter freundii AmpD N-acetylmuramyl-L-alanine amidase.
The Biochemical journal 2004;377(Pt 1):111-20.
2003: Frédéric Kerff; Paulette Charlier; Maria-Luigi Colombo; Eric Sauvage; Alain Brans; Jean-Marie Frère; Bernard Joris; Eveline Fonzé
Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis.
Biochemistry 2003;42(44):12835-43.
2003: Marc Vanhove; M Zakhem; Bart Devreese; Nicola Franceschini; Christine Anne; Carine Bebrone; Gianfranco Amicosante; Gian Maria Rossolini; Jozef Van Beeumen; Jean-Marie Frère; Moreno Galleni
Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-beta-lactamase.
Cellular and molecular life sciences : CMLS 2003;60(11):2501-9.
2003: Akiko Shimizu Ibuka; Yoshikazu Ishii; Moreno Galleni; Masaji Ishiguro; Keizo Yamaguchi; Jean-Marie Frère; Hiroshi Matsuzawa; Hiroshi Sakai
Crystal structure of extended-spectrum beta-lactamase Toho-1: insights into the molecular mechanism for catalytic reaction and substrate specificity expansion.
Biochemistry 2003;42(36):10634-43.
2003: Johan Wouters; Eveline Fonzé; Marcel Vermeire; Jean-Marie Frère; Paulette Charlier
Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue.
Cellular and molecular life sciences : CMLS 2003;60(8):1764-73.
2003: John W Anderson; Suara A Adediran; Paulette Charlier; Martine Nguyen-Distèche; Jean-Marie Frère; Robert A Nicholas; Rex F Pratt
On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides.
The Biochemical journal 2003;373(Pt 3):949-55.
2003: Isabel García-Saez; Julie Hopkins; Cyril Papamicael; Nicola Franceschini; Gianfranco Amicosante; Gian Maria Rossolini; Moreno Galleni; Jean-Marie Frère; Otto Dideberg
The 1.5-A structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, D-captopril.
The Journal of biological chemistry 2003;278(26):23868-73.
2003: Valérie Duval; Marc Swinnen; Sophie Lepage; Alain Brans; Benoît Granier; Christine Franssen; Jean-Marie Frère; Bernard Joris
The kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin-receptor shed a new light on the derepression of beta-lactamase synthesis.
Molecular microbiology 2003;48(6):1553-64.
2003: Patrice Filée; Christelle Vreuls; Raphaël Herman; Iris Thamm; Tony Aerts; Peter Paul De Deyn; Jean-Marie Frère; Bernard Joris
Dimerization and DNA binding properties of the Bacillus licheniformis 749/I BlaI repressor.
The Journal of biological chemistry 2003;278(19):16482-7.
2003: Catherine Moali; Christine Anne; Josette Lamotte-Brasseur; Sylvie Groslambert; Bart Devreese; Jozef Van Beeumen; Moreno Galleni; Jean-Marie Frère
Analysis of the importance of the metallo-beta-lactamase active site loop in substrate binding and catalysis.
Chemistry & biology 2003;10(4):319-29.
2003: Noureddine Rhazi; Paulette Charlier; Dominique Dehareng; Danièle Engher; Marcel Vermeire; Jean-Marie Frère; Martine Nguyen-Distèche; Eveline Fonzé
Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis.
Biochemistry 2003;42(10):2895-906.
2003: Jean-Denis Docquier; Josette Lamotte-Brasseur; Moreno Galleni; Gianfranco Amicosante; Jean-Marie Frère; Gian Maria Rossolini
On functional and structural heterogeneity of VIM-type metallo-beta-lactamases.
The Journal of antimicrobial chemotherapy 2003;51(2):257-66.
2003: Isabel García-Sáez; Paola Sandra Mercuri; Cyril Papamicael; R Kahn; Jean-Marie Frère; Moreno Galleni; Gian Maria Rossolini; Otto Dideberg
Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril.
Journal of molecular biology 2003;325(4):651-60.
2002: Bernard Lakaye; Alain Dubus; Bernard Joris; Jean-Marie Frère
Method for estimation of low outer membrane permeability to beta-lactam antibiotics.
Antimicrobial agents and chemotherapy 2002;46(9):2901-7.
2002: Jean-Denis Docquier; Fabrizio Pantanella; Francesco Giuliani; Maria Thaller; Gianfranco Amicosante; Moreno Galleni; Jean-Marie Frère; Karen Bush; Gian Maria Rossolini
CAU-1, a subclass B3 metallo-beta-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome.
Antimicrobial agents and chemotherapy 2002;46(6):1823-30.
2002: Patrice Filée; Kamal Benlafya; Michaël Delmarcelle; Georgios Moutzourelis; Jean-Marie Frère; Alain Brans; Bernard Joris
The fate of the BlaI repressor during the induction of the Bacillus licheniformis BlaP beta-lactamase.
Molecular microbiology 2002;44(3):685-94.
2002: Dominique de Seny; Christelle Prosperi-Meys; Carine Bebrone; Gian Maria Rossolini; Michael I Page; Philippe Noel; Jean-Marie Frère; Moreno Galleni
Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase.
The Biochemical journal 2002;363(Pt 3):687-96.
2002: Eveline Fonzé; Marc Vanhove; Georges Dive; Eric Sauvage; Jean-Marie Frère; Paulette Charlier
Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin.
Biochemistry 2002;41(6):1877-85.
2001: Nicola Franceschini; L Boschi; S Pollini; R Herman; Mariagrazia Perilli; Moreno Galleni; Jean-Marie Frère; Gianfranco Amicosante; Gian Maria Rossolini
Characterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties.
Antimicrobial agents and chemotherapy 2001;45(12):3509-16.
2001: Katja Conrath; Marc Lauwereys; Moreno Galleni; Alain Matagne; Jean-Marie Frère; Jörg Kinne; Lode Wyns; Serge Muyldermans
Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae.
Antimicrobial agents and chemotherapy 2001;45(10):2807-12.
2001: Annabelle Lejeune; Marc Vanhove; Josette Lamotte-Brasseur; RH Pain; Jean-Marie Frère; Alain Matagne
Quantitative analysis of the stabilization by substrate of Staphylococcus aureus PC1 beta-lactamase.
Chemistry & biology 2001;8(8):831-42.
2001: Han Remaut; C Bompard-Gilles; C Goffin; Jean-Marie Frère; Jozef Van Beeumen
Structure of the Bacillus subtilis D-aminopeptidase DppA reveals a novel self-compartmentalizing protease.
Nature structural biology 2001;8(8):674-8.
2001: Mateja Vilar; Moreno Galleni; Tom Solmajer; B Turk; Jean-Marie Frère; Alain Matagne
Kinetic study of two novel enantiomeric tricyclic beta-lactams which efficiently inactivate class C beta-lactamases.
Antimicrobial agents and chemotherapy 2001;45(8):2215-23.
2001: Astrid Zervosen; M H Valladares; Bart Devreese; Christelle Prosperi-Meys; Hans-Werner Adolph; Paola Sandra Mercuri; Marc Vanhove; Gianfranco Amicosante; Jozef Van Beeumen; Jean-Marie Frère; Moreno Galleni
Inactivation of Aeromonas hydrophila metallo-beta-lactamase by cephamycins and moxalactam.
European journal of biochemistry / FEBS 2001;268(13):3840-50.
2001: Carine Bebrone; Catherine Moali; F Mahy; Sandrine Rival; Jean-Denis Docquier; Gian Maria Rossolini; Jacques Fastrez; Rex F Pratt; Jean-Marie Frère; Moreno Galleni
CENTA as a chromogenic substrate for studying beta-lactamases.
Antimicrobial agents and chemotherapy 2001;45(6):1868-71.
2001: Paola Sandra Mercuri; Fabrice Bouillenne; L Boschi; Josette Lamotte-Brasseur; Gianfranco Amicosante; Bart Devreese; Jozef Van Beeumen; Jean-Marie Frère; Gian Maria Rossolini; Moreno Galleni
Biochemical characterization of the FEZ-1 metallo-beta-lactamase of Legionella gormanii ATCC 33297T produced in Escherichia coli.
Antimicrobial agents and chemotherapy 2001;45(4):1254-62.
2001: Moreno Galleni; Josette Lamotte-Brasseur; Gian Maria Rossolini; J Spencer; Otto Dideberg; Jean-Marie Frère
Standard numbering scheme for class B beta-lactamases.
Antimicrobial agents and chemotherapy 2001;45(3):660-3.
2001: Colette Duez; Marc Vanhove; X Gallet; Fabrice Bouillenne; Jean-Denis Docquier; Alain Brans; Jean-Marie Frère
Purification and characterization of PBP4a, a new low-molecular-weight penicillin-binding protein from Bacillus subtilis.
Journal of bacteriology 2001;183(5):1595-9.
2001: Johan Wouters; Paulette Charlier; D Monnaie; Jean-Marie Frère; Eveline Fonzé
Expression, purification, crystallization and preliminary X-ray analysis of the native class C beta-lactamase from Enterobacter cloacae 908R and two mutants.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 1):162-4.
2000: Alain Dubus; malkit sami; T J Brown; Christopher J Schofield; Jack E Baldwin; Jean-Marie Frère
Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
FEBS letters 2000;485(2-3):142-6.
2000: A Cheggour; L Fanuel; Colette Duez; Bernard Joris; Fabrice Bouillenne; Bart Devreese; Gonzalez Van Driessche; Jozef Van Beeumen; Jean-Marie Frère; Colette Goffin
The dppA gene of Bacillus subtilis encodes a new D-aminopeptidase.
Molecular microbiology 2000;38(3):504-13.
2000: Nicola Franceschini; B Caravelli; Jean-Denis Docquier; Moreno Galleni; Jean-Marie Frère; Gianfranco Amicosante; Gian Maria Rossolini
Purification and biochemical characterization of the VIM-1 metallo-beta-lactamase.
Antimicrobial agents and chemotherapy 2000;44(11):3003-7.
2000: C Bompard-Gilles; Han Remaut; Vincent Villeret; T Prangé; L Fanuel; Michaël Delmarcelle; Bernard Joris; Jean-Marie Frère; Jozef Van Beeumen
Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family.
Structure (London, England : 1993) 2000;8(9):971-80.
2000: Laurent Chantalat; E Duée; Moreno Galleni; Jean-Marie Frère; Otto Dideberg
Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase.
Protein science : a publication of the Protein Society 2000;9(7):1402-6.
2000: L Boschi; Paola Sandra Mercuri; Maria Letizia Riccio; Gianfranco Amicosante; Moreno Galleni; Jean-Marie Frère; Gian Maria Rossolini
The Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases.
Antimicrobial agents and chemotherapy 2000;44(6):1538-43.
2000: J Georis; Frédéric de Lemos Esteves; Josette Lamotte-Brasseur; V Bougnet; Bart Devreese; Fabrizio Giannotta; Benoît Granier; Jean-Marie Frère
An additional aromatic interaction improves the thermostability and thermophilicity of a mesophilic family 11 xylanase: structural basis and molecular study.
Protein science : a publication of the Protein Society 2000;9(3):466-75.
2000: C Bompard-Gilles; Vincent Villeret; G J Davies; L Fanuel; Bernard Joris; Jean-Marie Frère; Jozef Van Beeumen
A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi.
Structure (London, England : 1993) 2000;8(2):153-62.
2000: M Hernandez Valladares; Martin Kiefer; Uwe Heinz; R P Soto; Wolfram Meyer-Klaucke; HF Nolting; Michael Zeppezauer; Moreno Galleni; Jean-Marie Frère; Gian Maria Rossolini; Gianfranco Amicosante; Hans-Werner Adolph
Kinetic and spectroscopic characterization of native and metal-substituted beta-lactamase from Aeromonas hydrophila AE036.
FEBS letters 2000;467(2-3):221-5.
2000: Fabrice Bouillenne; Alain Matagne; Bernard Joris; Jean-Marie Frère
Technique for a rapid and efficient purification of the SHV-1 and PSE-2 beta-lactamases.
Journal of chromatography. B, Biomedical sciences and applications 2000;737(1-2):261-5.
1999: J Georis; Fabrizio Giannotta; Josette Lamotte-Brasseur; Bart Devreese; Jozef Van Beeumen; Benoît Granier; Jean-Marie Frère
Sequence, overproduction and purification of the family 11 endo-beta-1,4-xylanase encoded by the xyl1 gene of Streptomyces sp. S38.
Gene 1999;237(1):123-33.
1999: Gian Maria Rossolini; Nicola Franceschini; L Lauretti; B Caravelli; Maria Letizia Riccio; Moreno Galleni; Jean-Marie Frère; Gianfranco Amicosante
Cloning of a Chryseobacterium (Flavobacterium) meningosepticum chromosomal gene (blaA(CME)) encoding an extended-spectrum class A beta-lactamase related to the Bacteroides cephalosporinases and the VEB-1 and PER beta-lactamases.
Antimicrobial agents and chemotherapy 1999;43(9):2193-9.
1999: Noureddine Rhazi; Moreno Galleni; Michael I Page; Jean-Marie Frère
Peptidase activity of beta-lactamases.
The Biochemical journal 1999;341 ( Pt 2)():409-13.
1999: L Fanuel; Colette Goffin; A Cheggour; Bart Devreese; Gonzalez Van Driessche; Bernard Joris; Jozef Van Beeumen; Jean-Marie Frère
The DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family.
The Biochemical journal 1999;341 ( Pt 1)():147-55.
1999: R Paul-Soto; Rogert Bauer; Jean-Marie Frère; Moreno Galleni; Wolfram Meyer-Klaucke; HF Nolting; Gian Maria Rossolini; Dominique de Seny; M Hernandez Valladares; Michael Zeppezauer; Hans-Werner Adolph
Mono- and binuclear Zn2+-beta-lactamase. Role of the conserved cysteine in the catalytic mechanism.
The Journal of biological chemistry 1999;274(19):13242-9.
1999: L Fanuel; Iris Thamm; V Kostanjevecki; Bart Samyn; Bernard Joris; Colette Goffin; J Brannigan; Jozef Van Beeumen; Jean-Marie Frère
Two new aminopeptidases from Ochrobactrum anthropi active on D-alanyl-p-nitroanilide.
Cellular and molecular life sciences : CMLS 1999;55(5):812-8.
1999: N Laraki; Nicola Franceschini; Gian Maria Rossolini; P Santucci; C Meunier; Edwin De Pauw; Gianfranco Amicosante; Jean-Marie Frère; Moreno Galleni
Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli.
Antimicrobial agents and chemotherapy 1999;43(4):902-6.
1999: N Laraki; Moreno Galleni; Iris Thamm; M L Riccio; Gianfranco Amicosante; Jean-Marie Frère; Gian Maria Rossolini
Structure of In31, a blaIMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes.
Antimicrobial agents and chemotherapy 1999;43(4):890-901.
1999: C Bompard-Gilles; Vincent Villeret; L Fanuel; Bernard Joris; Jean-Marie Frère; Jozef Van Beeumen
Crystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 3):699-701.
1999: Alain Matagne; Alain Dubus; Moreno Galleni; Jean-Marie Frère
The beta-lactamase cycle: a tale of selective pressure and bacterial ingenuity.
Natural product reports 1999;16(1):1-19.
1999: Jean-Marie Frère; Alain Dubus; Moreno Galleni; Alain Matagne; Gianfranco Amicosante
Mechanistic diversity of beta-lactamases.
Biochemical Society transactions 1999;27(2):58-63.
1999: Bernard Lakaye; Alain Dubus; Sophie Lepage; Sylvie Groslambert; Jean-Marie Frère
When drug inactivation renders the target irrelevant to antibiotic resistance: a case story with beta-lactams.
Molecular microbiology 1999;31(1):89-101.
1998: R Paul-Soto; M Hernandez Valladares; Moreno Galleni; Rogert Bauer; Michael Zeppezauer; Jean-Marie Frère; Hans-Werner Adolph
Mono- and binuclear Zn-beta-lactamase from Bacteroides fragilis: catalytic and structural roles of the zinc ions.
FEBS letters 1998;438(1-2):137-40.
1998: J M Wilkin; Josette Lamotte-Brasseur; Jean-Marie Frère
The catalytic mechanism of DD-peptidases: unexpected importance of tyrosine 280 in the transpeptidation reaction catalysed by the Streptomyces R61 DD-peptidase.
Cellular and molecular life sciences : CMLS 1998;54(7):726-32.
1998: A Carfi; E Duée; Moreno Galleni; Jean-Marie Frère; Otto Dideberg
1.85 A resolution structure of the zinc (II) beta-lactamase from Bacillus cereus.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 3):313-23.
1998: Alain Matagne; Josette Lamotte-Brasseur; Jean-Marie Frère
Catalytic properties of class A beta-lactamases: efficiency and diversity.
The Biochemical journal 1998;330 ( Pt 2)():581-98.
1998: Marc Vanhove; Annabelle Lejeune; Gilliane Guillaume; R Virden; RH Pain; F X Schmid; Jean-Marie Frère
A collapsed intermediate with nonnative packing of hydrophobic residues in the folding of TEM-1 beta-lactamase.
Biochemistry 1998;37(7):1941-50.
1998: A Carfi; E Duée; R Paul-Soto; Moreno Galleni; Jean-Marie Frère; Otto Dideberg
X-ray structure of the ZnII beta-lactamase from Bacteroides fragilis in an orthorhombic crystal form.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 1):45-57.
1997: X Raquet; Valère Lounnas; Josette Lamotte-Brasseur; Jean-Marie Frère; Rebecca C Wade
pKa calculations for class A beta-lactamases: methodological and mechanistic implications.
Biophysical journal 1997;73(5):2416-26.
1997: G H Zhao; Colette Duez; Sophie Lepage; C Forceille; Noureddine Rhazi; D Klein; Jean-Marie Ghuysen; Jean-Marie Frère
Site-directed mutagenesis of the Actinomadura R39 DD-peptidase.
The Biochemical journal 1997;327 ( Pt 2)():377-81.
1997: M Adam; Claudine Fraipont; Noureddine Rhazi; Martine Nguyen-Distèche; Bernard Lakaye; Jean-Marie Frère; Bart Devreese; Jozef Van Beeumen; Y van Heijenoort; Jean Van Heijenoort; Jean-Marie Ghuysen
The bimodular G57-V577 polypeptide chain of the class B penicillin-binding protein 3 of Escherichia coli catalyzes peptide bond formation from thiolesters and does not catalyze glycan chain polymerization from the lipid II intermediate.
Journal of bacteriology 1997;179(19):6005-9.
1997: M Hernandez Valladares; A Felici; G Weber; Hans-Werner Adolph; Michael Zeppezauer; Gian Maria Rossolini; Gianfranco Amicosante; Jean-Marie Frère; Moreno Galleni
Zn(II) dependence of the Aeromonas hydrophila AE036 metallo-beta-lactamase activity and stability.
Biochemistry 1997;36(38):11534-41.
1997: Philippe Ledent; Colette Duez; Marc Vanhove; Annabelle Lejeune; Eveline Fonzé; Paulette Charlier; F Rhazi-Filali; Iris Thamm; Gilliane Guillaume; Bart Samyn; Bart Devreese; Jozef Van Beeumen; Josette Lamotte-Brasseur; Jean-Marie Frère
Unexpected influence of a C-terminal-fused His-tag on the processing of an enzyme and on the kinetic and folding parameters.
FEBS letters 1997;413(2):194-6.
1997: A Carfí; R Paul-Soto; Lydie Martin; Y Pétillot; Jean-Marie Frère; Otto Dideberg
Purification, crystallization and preliminary X-ray analysis of Bacteroides fragilis Zn2+ beta-lactamase.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 4):485-7.
1997: Birgit Quinting; Reyrat Jean-Marc; D Monnaie; Gianfranco Amicosante; Vladimir Pelicic; B Gicquel; Jean-Marie Frère; Moreno Galleni
Contribution of beta-lactamase production to the resistance of mycobacteria to beta-lactam antibiotics.
FEBS letters 1997;406(3):275-8.
1997: Birgit Quinting; Moreno Galleni; J Timm; B Gicquel; Gianfranco Amicosante; Jean-Marie Frère
Purification and properties of the Mycobacterium smegmatis mc(2)155 beta-lactamase.
FEMS microbiology letters 1997;149(1):11-5.
1997: C Jacobs; Jean-Marie Frère; S Normark
Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria.
Cell 1997;88(6):823-32.
1997: Karin Hardt; Bernard Joris; Sophie Lepage; Robert Brasseur; J O Lampen; Jean-Marie Frère; Anthony L Fink; Jean-Marie Ghuysen
The penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in Bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle.
Molecular microbiology 1997;23(5):935-44.
1997: Gilliane Guillaume; Marc Vanhove; Josette Lamotte-Brasseur; Philippe Ledent; M Jamin; Bernard Joris; Jean-Marie Frère
Site-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies.
The Journal of biological chemistry 1997;272(9):5438-44.
1997: G H Zhao; Jean-Marie Frère
Reversible inhibition of enzymatic systems involving covalent intermediates.
Journal of enzyme inhibition 1997;11(4):245-64.
1997: Marc Vanhove; Gilliane Guillaume; Philippe Ledent; J H Richards; RH Pain; Jean-Marie Frère
Kinetic and thermodynamic consequences of the removal of the Cys-77-Cys-123 disulphide bond for the folding of TEM-1 beta-lactamase.
The Biochemical journal 1997;321 ( Pt 2)():413-7.
1997: X Raquet; Josette Lamotte-Brasseur; Fabrice Bouillenne; Jean-Marie Frère
A disulfide bridge near the active site of carbapenem-hydrolyzing class A beta-lactamases might explain their unusual substrate profile.
Proteins 1997;27(1):47-58.
1996: Alain Dubus; Philippe Ledent; Josette Lamotte-Brasseur; Jean-Marie Frère
The roles of residues Tyr150, Glu272, and His314 in class C beta-lactamases.
Proteins 1996;25(4):473-85.
1996: Marc Vanhove; X Raquet; T Palzkill; RH Pain; Jean-Marie Frère
The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 beta-lactamase is the trans to cis isomerization of a non-proline peptide bond.
Proteins 1996;25(1):104-11.
1996: V Mainfroid; P Terpstra; M Beauregard; Jean-Marie Frère; S C Mande; Wim G J Hol; Joseph A Martial; K Goraj
Three hTIM mutants that provide new insights on why TIM is a dimer.
Journal of molecular biology 1996;257(2):441-56.
1996: C Damblon; X Raquet; L Y Lian; Josette Lamotte-Brasseur; E Fonze; Paulette Charlier; Gordon Roberts; Jean-Marie Frère
The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):1747-52.
1996: M Hernandez Villadares; Moreno Galleni; Jean-Marie Frère; A Felici; Mariagrazia Perilli; Nicola Franceschini; Gian Maria Rossolini; Arduino Oratore; Gianfranco Amicosante
Overproduction and purification of the Aeromonas hydrophila CphA metallo-beta-lactamase expressed in Escherichia coli.
Microbial drug resistance (Larchmont, N.Y.) 1996;2(2):253-6.
1995: A Carfi; S Pares; E Duée; Moreno Galleni; Colette Duez; Jean-Marie Frère; Otto Dideberg
The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.
The EMBO journal 1995;14(20):4914-21.
1995: Eveline Fonzé; Paulette Charlier; Y To'th; M Vermeire; X Raquet; Alain Dubus; Jean-Marie Frère
TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):682-94.
1995: X Raquet; Marc Vanhove; Josette Lamotte-Brasseur; S Goussard; P Courvalin; Jean-Marie Frère
Stability of TEM beta-lactamase mutants hydrolyzing third generation cephalosporins.
Proteins 1995;23(1):63-72.
1995: C Damblon; G H Zhao; M Jamin; Philippe Ledent; Alain Dubus; Marc Vanhove; X Raquet; L Christiaens; Jean-Marie Frère
Breakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates.
The Biochemical journal 1995;309 ( Pt 2)():431-6.
1995: Marc Vanhove; S Houba; J b1motte-Brasseur; Jean-Marie Frère
Probing the determinants of protein stability: comparison of class A beta-lactamases.
The Biochemical journal 1995;308 ( Pt 3)():859-64.
1995: Marc Vanhove; X Raquet; Jean-Marie Frère
Investigation of the folding pathway of the TEM-1 beta-lactamase.
Proteins 1995;22(2):110-8.
1995: Moreno Galleni; Josette Lamotte-Brasseur; X Raquet; Alain Dubus; D Monnaie; J R Knox; Jean-Marie Frère
The enigmatic catalytic mechanism of active-site serine beta-lactamases.
Biochemical pharmacology 1995;49(9):1171-8.
1995: Jean-Marie Frère
Beta-lactamases and bacterial resistance to antibiotics.
Molecular microbiology 1995;16(3):385-95.
1995: J Grandchamps; Martine Nguyen-Distèche; C Damblon; Jean-Marie Frère; Jean-Marie Ghuysen
Streptomyces K15 active-site serine DD-transpeptidase: specificity profile for peptide, thiol ester and ester carbonyl donors and pathways of the transfer reactions.
The Biochemical journal 1995;307 ( Pt 2)():335-9.
1995: Sophie Lepage; Bernard Lakaye; Moreno Galleni; Iris Thamm; M Crine; S Groslambert; Jean-Marie Frère
Saturation of penicillin-binding protein 1 by beta-lactam antibiotics in growing cells of Bacillus licheniformis.
Molecular microbiology 1995;16(2):365-72.
1995: C Jacobs; Bernard Joris; M Jamin; K Klarsov; J Van Beeumen; Dominique Mengin-Lecreulx; Jean Van Heijenoort; James T Park; Staffan Normark; Jean-Marie Frère
AmpD, essential for both beta-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-L-alanine amidase.
Molecular microbiology 1995;15(3):553-9.
1995: Moreno Galleni; X Raquet; Josette Lamotte-Brasseur; Eveline Fonzé; Gianfranco Amicosante; Jean-Marie Frère
DD-peptidases and beta-lactamases: catalytic mechanisms and specificities.
Journal of chemotherapy (Florence, Italy) 1995;7(1):3-7.
1995: Alain Matagne; Jean-Marie Frère
Contribution of mutant analysis to the understanding of enzyme catalysis: the case of class A beta-lactamases.
Biochimica et biophysica acta 1995;1246(2):109-27.
1995: M Jamin; J M Wilkin; Jean-Marie Frère
Bacterial DD-transpeptidases and penicillin.
Essays in biochemistry 1995;29():1-24.
1995: Alain Matagne; Philippe Ledent; D Monnaie; A Felici; M Jamin; X Raquet; Moreno Galleni; D Klein; I François; Jean-Marie Frère
Kinetic study of interaction between BRL 42715, beta-lactamases, and D-alanyl-D-alanine peptidases.
Antimicrobial agents and chemotherapy 1995;39(1):227-31.
1994: X Raquet; Josette Lamotte-Brasseur; Eveline Fonzé; S Goussard; P Courvalin; Jean-Marie Frère
TEM beta-lactamase mutants hydrolysing third-generation cephalosporins. A kinetic and molecular modelling analysis.
Journal of molecular biology 1994;244(5):625-39.
1994: M Datz; Bernard Joris; E A Azab; Moreno Galleni; J Van Beeumen; Jean-Marie Frère; H H Martin
A common system controls the induction of very different genes. The class-A beta-lactamase of Proteus vulgaris and the enterobacterial class-C beta-lactamase.
European journal of biochemistry / FEBS 1994;226(1):149-57.
1994: Colette Duez; C Piron-Fraipont; Bernard Joris; Jean Dusart; M S Urdea; J A Martial; Jean-Marie Frère; Jean-Marie Ghuysen
Primary structure of the Streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene.
European journal of biochemistry / FEBS 1994;224(3):1079.
1994: L Fanuel; B Granier; J M Wilkin; C Bellefroid-Bourguignon; Bernard Joris; J Knowles; E Komives; J Van Beeumen; Jean-Marie Ghuysen; Jean-Marie Frère
The precursor of the Streptomyces R61 DD-peptidase containing a C-terminal extension is inactive.
FEBS letters 1994;351(1):49-52.
1994: D Monnaie; Alain Dubus; Jean-Marie Frère
The role of lysine-67 in a class C beta-lactamase is mainly electrostatic.
The Biochemical journal 1994;302 ( Pt 1)():1-4.
1994: Alain Dubus; J M Wilkin; X Raquet; Staffan Normark; Jean-Marie Frère
Catalytic mechanism of active-site serine beta-lactamases: role of the conserved hydroxy group of the Lys-Thr(Ser)-Gly triad.
The Biochemical journal 1994;301 ( Pt 2)():485-94.
1994: J M Wilkin; Alain Dubus; Bernard Joris; Jean-Marie Frère
The mechanism of action of DD-peptidases: the role of Threonine-299 and -301 in the Streptomyces R61 DD-peptidase.
The Biochemical journal 1994;301 ( Pt 2)():477-83.
1994: M Jamin; C Damblon; A M Bauduin-Misselyn; F Durant; Gordon Roberts; Paulette Charlier; G Llabres; Jean-Marie Frère
Direct n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase.
The Biochemical journal 1994;301 ( Pt 1)():199-203.
1994: Moreno Galleni; Nicola Franceschini; Birgit Quinting; Lanfranco Fattorini; G Orefici; Arduino Oratore; Jean-Marie Frère; Gianfranco Amicosante
Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.
Antimicrobial agents and chemotherapy 1994;38(7):1608-14.
1994: D Monnaie; Alain Dubus; D Cooke; Jacqueline Marchand-Brynaert; Staffan Normark; Jean-Marie Frère
Role of residue Lys315 in the mechanism of action of the Enterobacter cloacae 908R beta-lactamase.
Biochemistry 1994;33(17):5193-201.
1994: J Timm; Mariagrazia Perilli; C Duez; J Trias; G Orefici; Lanfranco Fattorini; Gianfranco Amicosante; Arduino Oratore; B Joris; Jean-Marie Frère
Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer.
Molecular microbiology 1994;12(3):491-504.
1993: Philippe Ledent; Jean-Marie Frère
Substrate-induced inactivation of the OXA2 beta-lactamase.
The Biochemical journal 1993;295 ( Pt 3)():871-8.
1993: Alain Matagne; M F Ghuysen; Jean-Marie Frère
Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview.
The Biochemical journal 1993;295 ( Pt 3)():705-11.
1993: Alain Matagne; Josette Lamotte-Brasseur; Jean-Marie Frère
Interactions between active-site serine beta-lactamases and so-called beta-lactamase-stable antibiotics. Kinetic and molecular modelling studies.
European journal of biochemistry / FEBS 1993;217(1):61-7.
1993: Alain Matagne; Josette Lamotte-Brasseur; Georges Dive; J R Knox; Jean-Marie Frère
Interactions between active-site-serine beta-lactamases and compounds bearing a methoxy side chain on the alpha-face of the beta-lactam ring: kinetic and molecular modelling studies.
The Biochemical journal 1993;293 ( Pt 3)():607-11.
1993: M Jamin; J M Wilkin; Jean-Marie Frère
A new kinetic mechanism for the concomitant hydrolysis and transfer reactions catalyzed by bacterial DD-peptidases.
Biochemistry 1993;32(28):7278-85.
1993: M Jamin; C Damblon; S Millier; Regine Hakenbeck; Jean-Marie Frère
Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.
The Biochemical journal 1993;292 ( Pt 3)():735-41.
1993: Alain Dubus; D Monnaie; C Jacobs; Staffan Normark; Jean-Marie Frère
A dramatic change in the rate-limiting step of beta-lactam hydrolysis results from the substitution of the active-site serine residue by a cysteine in the class-C beta-lactamase of Enterobacter cloacae 908R.
The Biochemical journal 1993;292 ( Pt 2)():537-43.
1993: Philippe Ledent; X Raquet; Bernard Joris; J Van Beeumen; Jean-Marie Frère
A comparative study of class-D beta-lactamases.
The Biochemical journal 1993;292 ( Pt 2)():555-62.
1993: J M Wilkin; M Jamin; C Damblon; G H Zhao; Bernard Joris; Colette Duez; Jean-Marie Frère
The mechanism of action of DD-peptidases: the role of tyrosine-159 in the Streptomyces R61 DD-peptidase.
The Biochemical journal 1993;291 ( Pt 2)():537-44.
1993: A Felici; Gianfranco Amicosante; Arduino Oratore; R Strom; Philippe Ledent; Bernard Joris; L Fanuel; Jean-Marie Frère
An overview of the kinetic parameters of class B beta-lactamases.
The Biochemical journal 1993;291 ( Pt 1)():151-5.
1993: Moreno Galleni; Bernard Lakaye; Sophie Lepage; M Jamin; Iris Thamm; Bernard Joris; Jean-Marie Frère
A new, highly sensitive method for the detection and quantification of penicillin-binding proteins.
The Biochemical journal 1993;291 ( Pt 1)():19-21.
1992: B Granier; Colette Duez; Sophie Lepage; S Englebert; Jean Dusart; Otto Dideberg; J Van Beeumen; Jean-Marie Frère; Jean-Marie Ghuysen
Primary and predicted secondary structure of the Actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4.
The Biochemical journal 1992;286 ( Pt 3)():981-2.
1992: G Laible; W Keck; Rudi Lurz; H Mottl; Jean-Marie Frère; M Jamin; Regine Hakenbeck
Penicillin-binding protein 2x of Streptococcus pneumoniae. Expression in Escherichia coli and purification of a soluble enzymatically active derivative.
European journal of biochemistry / FEBS 1992;207(3):943-9.
1992: D Monnaie; Richard Virden; Jean-Marie Frère
A rapid-kinetic study of the class C beta-lactamase of Enterobacter cloacae 908R.
FEBS letters 1992;306(2-3):108-12.
1992: A M Hadonou; J M Wilkin; L Varetto; Bernard Joris; Josette Lamotte-Brasseur; D Klein; Colette Duez; Jean-Marie Ghuysen; Jean-Marie Frère
Site-directed mutagenesis of the Streptomyces R61 DD-peptidase. Catalytic function of the conserved residues around the active site and a comparison with class-A and class-C beta-lactamases.
European journal of biochemistry / FEBS 1992;207(1):97-102.
1992: C Jacobs; Alain Dubus; D Monnaie; Staffan Normark; Jean-Marie Frère
Mutation of serine residue 318 in the class C beta-lactamase of Enterobacter cloacae 908R.
FEMS microbiology letters 1992;71(1):95-100.
1992: C Bourguignon-Bellefroid; Bernard Joris; J Van Beeumen; Jean-Marie Ghuysen; Jean-Marie Frère
Point mutations of two arginine residues in the Streptomyces R61 DD-peptidase.
The Biochemical journal 1992;283 ( Pt 1)():123-8.
1992: B Granier; Colette Duez; Sophie Lepage; S Englebert; Jean Dusart; Otto Dideberg; J Van Beeumen; Jean-Marie Frère; Jean-Marie Ghuysen
Primary and predicted secondary structures of the Actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4.
The Biochemical journal 1992;282 ( Pt 3)():781-8.
1992: A M Hadonou; M Jamin; M Adam; Bernard Joris; Jean Dusart; Jean-Marie Ghuysen; Jean-Marie Frère
Importance of the His-298 residue in the catalytic mechanism of the Streptomyces R61 extracellular DD-peptidase.
The Biochemical journal 1992;282 ( Pt 2)():495-500.
1992: C Bourguignon-Bellefroid; J M Wilkin; Bernard Joris; R T Aplin; C Houssier; F G Prendergast; J Van Beeumen; Jean-Marie Ghuysen; Jean-Marie Frère
Importance of the two tryptophan residues in the Streptomyces R61 exocellular DD-peptidase.
The Biochemical journal 1992;282 ( Pt 2)():361-7.
1992: Josette Lamotte-Brasseur; F Jacob-Dubuisson; Georges Dive; Jean-Marie Frère; Jean-Marie Ghuysen
Streptomyces albus G serine beta-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes.
The Biochemical journal 1992;282 ( Pt 1)():189-95.
1991: Alain Matagne; Bernard Joris; Jean-Marie Frère
Anomalous behaviour of a protein during SDS/PAGE corrected by chemical modification of carboxylic groups.
The Biochemical journal 1991;280 ( Pt 2)():553-6.
1991: M Jamin; M Adam; C Damblon; L Christiaens; Jean-Marie Frère
Accumulation of acyl-enzyme in DD-peptidase-catalysed reactions with analogues of peptide substrates.
The Biochemical journal 1991;280 ( Pt 2)():499-506.
1991: Bernard Joris; Philippe Ledent; Otto Dideberg; Eveline Fonzé; Josette Lamotte-Brasseur; J A Kelly; Jean-Marie Ghuysen; Jean-Marie Frère
Comparison of the sequences of class A beta-lactamases and of the secondary structure elements of penicillin-recognizing proteins.
Antimicrobial agents and chemotherapy 1991;35(11):2294-301.
1991: Josette Lamotte-Brasseur; Georges Dive; Otto Dideberg; Paulette Charlier; Jean-Marie Frère; Jean-Marie Ghuysen
Mechanism of acyl transfer by the class A serine beta-lactamase of Streptomyces albus G.
The Biochemical journal 1991;279 ( Pt 1)():213-21.
1991: F Jacob-Dubuisson; Josette Lamotte-Brasseur; Otto Dideberg; Bernard Joris; Jean-Marie Frère
Arginine 220 is a critical residue for the catalytic mechanism of the Streptomyces albus G beta-lactamase.
Protein engineering 1991;4(7):811-9.
1991: J Brannigan; Alain Matagne; F Jacob; C Damblon; Bernard Joris; D Klein; Brian G Spratt; Jean-Marie Frère
The mutation Lys234His yields a class A beta-lactamase with a novel pH-dependence.
The Biochemical journal 1991;278 ( Pt 3)():673-8.
1991: L Varetto; F De Meester; D Monnaie; Jacqueline Marchand-Brynaert; Georges Dive; F Jacob; Jean-Marie Frère
The importance of the negative charge of beta-lactam compounds in the interactions with active-site serine DD-peptidases and beta-lactamases.
The Biochemical journal 1991;278 ( Pt 3)():801-7.
1991: Mariagrazia Perilli; Nicola Franceschini; Bernardetta Segatore; Gianfranco Amicosante; Arduino Oratore; C Duez; B Joris; Jean-Marie Frère
Cloning and nucleotide sequencing of the gene encoding the beta-lactamase from Citrobacter diversus.
FEMS microbiology letters 1991;67(1):79-84.
1991: F Jacob; Bernard Joris; Jean-Marie Frère
Active-site serine mutants of the Streptomyces albus G beta-lactamase.
The Biochemical journal 1991;277 ( Pt 3)():647-52.
1991: Jean-Marie Frère; Bernard Joris; B Granier; Alain Matagne; F Jacob; C Bourguignon-Bellefroid
Diversity of the mechanisms of resistance to beta-lactam antibiotics.
Research in microbiology 1991;142(6):705-10.
1991: Nicola Franceschini; Gianfranco Amicosante; Mariagrazia Perilli; Mauro Maccarrone; Arduino Oratore; J van Beeumen; Jean-Marie Frère
Proteolytic interconversion and N-terminal sequences of the Citrobacter diversus major beta-lactamases.
The Biochemical journal 1991;275 ( Pt 3)():629-33.
1991: Alain Matagne; Bernard Joris; J Van Beeumen; Jean-Marie Frère
Ragged N-termini and other variants of class A beta-lactamases analysed by chromatofocusing.
The Biochemical journal 1991;273 ( Pt 3)():503-10.
1990: F Jacob; Bernard Joris; Sophie Lepage; Jean Dusart; Jean-Marie Frère
Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis.
The Biochemical journal 1990;271(2):399-406.
1990: F Jacob; Bernard Joris; Otto Dideberg; Jean Dusart; Jean-Marie Ghuysen; Jean-Marie Frère
Engineering a novel beta-lactamase by a single point mutation.
Protein engineering 1990;4(1):79-86.
1990: M Adam; C Damblon; B Plaitin; L Christiaens; Jean-Marie Frère
Chromogenic depsipeptide substrates for beta-lactamases and penicillin-sensitive DD-peptidases.
The Biochemical journal 1990;270(2):525-9.
1990: P C Moews; James R Knox; Otto Dideberg; Paulette Charlier; Jean-Marie Frère
Beta-lactamase of Bacillus licheniformis 749/C at 2 A resolution.
Proteins 1990;7(2):156-71.
1990: Alain Matagne; A M Misselyn-Bauduin; Bernard Joris; T Erpicum; B Granier; Jean-Marie Frère
The diversity of the catalytic properties of class A beta-lactamases.
The Biochemical journal 1990;265(1):131-46.
1989: S Houba; S Willem; Colette Duez; C Molitor; Jean Dusart; Jean-Marie Frère; Jean-Marie Ghuysen
Nucleotide sequence of the gene encoding the active-site serine beta-lactamase from Actinomadura R39.
FEMS microbiology letters 1989;53(3):241-6.
1989: J A Kelly; James R Knox; H Zhao; Jean-Marie Frère; J M Ghaysen
Crystallographic mapping of beta-lactams bound to a D-alanyl-D-alanine peptidase target enzyme.
Journal of molecular biology 1989;209(2):281-95.
1989: C Piron-Fraipont; Colette Duez; Alain Matagne; C Molitor; Jean Dusart; Jean-Marie Frère; Jean-Marie Ghuysen
Cloning and amplified expression in Streptomyces lividans of the gene encoding the extracellular beta-lactamase of Actinomadura R39.
The Biochemical journal 1989;262(3):849-54.
1989: Jean-Marie Frère
Quantitative relationship between sensitivity to beta-lactam antibiotics and beta-lactamase production in gram-negative bacteria--I. Steady-state treatment.
Biochemical pharmacology 1989;38(9):1415-26.
1989: U Hechler; M van den Weghe; H H Martin; Jean-Marie Frère
Overproduced beta-lactamase and the outer-membrane barrier as resistance factors in Serratia marcescens highly resistant to beta-lactamase-stable beta-lactam antibiotics.
Journal of general microbiology 1989;135(5):1275-90.
1989: Jean-Marie Frère; Bernard Joris; M Crine; H H Martin
Quantitative relationship between sensitivity to beta-lactam antibiotics and beta-lactamase production in gram-negative bacteria--II. Non-steady-state treatment and progress curves.
Biochemical pharmacology 1989;38(9):1427-33.
1989: F De Meester; Alain Matagne; Georges Dive; Jean-Marie Frère
Unexpected influence of ionic strength on branched-pathway interactions between beta-lactamases and beta-halogenopenicillanates.
The Biochemical journal 1989;257(1):245-9.
1988: Jean-Marie Frère; Bernard Joris; Otto Dideberg; Paulette Charlier; J M Ghuysen
Penicillin-recognizing enzymes.
Biochemical Society transactions 1988;16(6):934-8.
1988: Moreno Galleni; Gianfranco Amicosante; Jean-Marie Frère
A survey of the kinetic parameters of class C beta-lactamases. Cephalosporins and other beta-lactam compounds.
The Biochemical journal 1988;255(1):123-9.
1988: Moreno Galleni; Jean-Marie Frère
A survey of the kinetic parameters of class C beta-lactamases. Penicillins.
The Biochemical journal 1988;255(1):119-22.
1988: Gianfranco Amicosante; Arduino Oratore; Nicola Franceschini; Mauro Maccarrone; R Strom; Moreno Galleni; Jean-Marie Frère
Citrobacter diversus ULA-27 beta-lactamases. Improved purification and general properties.
The Biochemical journal 1988;254(3):885-90.
1988: Bernard Joris; Jean-Marie Ghuysen; Georges Dive; A Renard; Otto Dideberg; Paulette Charlier; Jean-Marie Frère; J A Kelly; J C Boyington; P C Moews
The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 DD-peptidase family.
The Biochemical journal 1988;250(2):313-24.
1988: Jean-Marie Frère; Bernard Joris; L Varetto; M Crine
Structure-activity relationships in the beta-lactam family: an impossible dream.
Biochemical pharmacology 1988;37(1):125-32.
1988: Jean-Marie Frère; Bernard Joris
Beta-lactamases as the main resistance factor to penicillin-related antibiotics.
Annales de biologie clinique 1988;46(2):151-6.
1987: L Varetto; Jean-Marie Frère; Jean-Marie Ghuysen
The importance of the negative charge of beta-lactam compounds for the inactivation of the active-site serine DD-peptidase of Streptomyces R61.
FEBS letters 1987;225(1-2):218-22.
1987: Otto Dideberg; Paulette Charlier; J P Wéry; P Dehottay; Jean Dusart; T Erpicum; Jean-Marie Frère; Jean-Marie Ghuysen
The crystal structure of the beta-lactamase of Streptomyces albus G at 0.3 nm resolution.
The Biochemical journal 1987;245(3):911-3.
1987: P Dehottay; Jean Dusart; F De Meester; Bernard Joris; J Van Beeumen; T Erpicum; Jean-Marie Frère; Jean-Marie Ghuysen
Nucleotide sequence of the gene encoding the Streptomyces albus G beta-lactamase precursor.
European journal of biochemistry / FEBS 1987;166(2):345-50.
1987: F De Meester; Bernard Joris; G Reckinger; C Bellefroid-Bourguignon; Jean-Marie Frère; S G Waley
Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases.
Biochemical pharmacology 1987;36(14):2393-403.
1987: F De Meester; Bernard Joris; M V Lenzini; P Dehottay; T Erpicium; Jean Dusart; D Klein; Jean-Marie Ghuysen; Jean-Marie Frère; J Van Beeumen
The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G.
The Biochemical journal 1987;244(2):427-32.
1987: Bernard Joris; F De Meester; Moreno Galleni; Jean-Marie Frère; J Van Beeumen
The K1 beta-lactamase of Klebsiella pneumoniae.
The Biochemical journal 1987;243(2):561-7.
1987: Colette Duez; C Piron-Fraipont; Bernard Joris; Jean Dusart; M S Urdea; J A Martial; Jean-Marie Frère; Jean-Marie Ghuysen
Primary structure of the Streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene.
European journal of biochemistry / FEBS 1987;162(3):509-18.
1986: Bernard Joris; F De Meester; Moreno Galleni; S Masson; Jean Dusart; Jean-Marie Frère; J Van Beeumen; K Bush; R Sykes
Properties of a class C beta-lactamase from Serratia marcescens.
The Biochemical journal 1986;239(3):581-6.
1986: F De Meester; Jean-Marie Frère; S G Waley; S J Cartwright; R Virden; F Lindberg
6-beta-Iodopenicillanate as a probe for the classification of beta-lactamases.
The Biochemical journal 1986;239(3):575-80.
1986: Jean-Marie Ghuysen; Jean-Marie Frère; M Leyh-Bouille; Martine Nguyen-Distèche; Jacques Coyette
Active-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions. Procedures for studying the penicillin-binding proteins of bacterial plasma membranes.
The Biochemical journal 1986;235(1):159-65.
1986: Martine Nguyen-Distèche; M Leyh-Bouille; S Pirlot; Jean-Marie Frère; Jean-Marie Ghuysen
Streptomyces K15 DD-peptidase-catalysed reactions with ester and amide carbonyl donors.
The Biochemical journal 1986;235(1):167-76.
1986: P Dehottay; Jean Dusart; Colette Duez; M V Lenzini; J A Martial; Jean-Marie Frère; Jean-Marie Ghuysen; T Kieser
Cloning and amplified expression in Streptomyces lividans of a gene encoding extracellular beta-lactamase from Streptomyces albus G.
Gene 1986;42(1):31-6.
1985: J A Kelly; James R Knox; P C Moews; G J Hite; J B Bartolone; H Zhao; Bernard Joris; Jean-Marie Frère; Jean-Marie Ghuysen
2.8-A Structure of penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase from Streptomyces R61 and complexes with beta-lactams.
The Journal of biological chemistry 1985;260(10):6449-58.
1985: M V Lenzini; Jean-Marie Frère
The beta-lactamase of Streptomyces cacaoi: interaction with cefoxitin and beta-iodopenicillanate.
Journal of enzyme inhibition 1985;1(1):25-34.
1984: Paulette Charlier; Otto Dideberg; J C Jamoulle; Jean-Marie Frère; Jean-Marie Ghuysen; Georges Dive; Josette Lamotte-Brasseur
Active-site-directed inactivators of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G.
The Biochemical journal 1984;219(3):763-72.
1984: Jean-Marie Ghuysen; Jean-Marie Frère; M Leyh-Bouille; Martine Nguyen-Distèche; Jacques Coyette; Jean Dusart; Bernard Joris; Colette Duez; Otto Dideberg; Paulette Charlier
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics.
Scandinavian journal of infectious diseases. Supplementum 1984;42():17-37.
1983: Paulette Charlier; Otto Dideberg; Jean-Marie Frère; P C Moews; James R Knox
Crystallographic data for the beta-lactamase from Enterobacter cloacae P99.
Journal of molecular biology 1983;171(2):237-8.
1982: J A Kelly; P C Moews; James R Knox; Jean-Marie Frère; Jean-Marie Ghuysen
Penicillin target enzyme and the antibiotic binding site.
Science (New York, N.Y.) 1982;218(4571):479-81.
1982: Otto Dideberg; Paulette Charlier; Georges Dive; Bernard Joris; Jean-Marie Frère; Jean-Marie Ghuysen
Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 A resolution.
Nature 1982;299(5882):469-70.