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Manuel Fresno

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Chagas' Disease

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Ricardo S Corral; Henar Cuervo; Núria Gironès; Néstor A Guerrero; Manuel Fresno
Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes.
Sandra Donnini; Federica Finetti; Manuel Fresno; Antonio Giachetti; H Hanaka; Miguel A Iñiguez; O Rådmark; E Terzuoli; Marina Ziche
EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.
Vinatha Sreeramkumar; Manuel Fresno; Natalia Cuesta
Prostaglandin E2 and T cells: friends or foes?

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2013: Ricardo S Corral; Henar Cuervo; Núria Gironès; Néstor A Guerrero; Manuel Fresno
Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes.
PLoS neglected tropical diseases 2013;7(2):e2034.
2012: Sandra Donnini; Federica Finetti; Manuel Fresno; Antonio Giachetti; H Hanaka; Miguel A Iñiguez; O Rådmark; E Terzuoli; Marina Ziche
EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.
Oncogene 2012;31(29):3457-66.
2012: Vinatha Sreeramkumar; Manuel Fresno; Natalia Cuesta
Prostaglandin E2 and T cells: friends or foes?
Immunology and cell biology 2012;90(6):579-86.
2012: Manuel D Díaz-Muñoz; Manuel Fresno; Inés C Osma-García; Miguel A Iñiguez
Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages.
The Biochemical journal 2012;443(2):451-61.
2012: Carolina Aquilino; Laura Corvo; Leticia Escudero; Manuel Fresno; Maria Luisa Gonzalez Rubio; Francisco Malpartida; Elena Maria Seco; Manuel Soto; Pedro Bonay
Differential trypanocidal activity of novel macrolide antibiotics; correlation to genetic lineage.
PloS one 2012;7(7):e40901.
2012: Jossela Calderón; JAVIER Carrión; Elena Maganto-Garcia; Carmen Punzón; Cox Terhorst; Manuel Fresno
The receptor Slamf1 on the surface of myeloid lineage cells controls susceptibility to infection by Trypanosoma cruzi.
PLoS pathogens 2012;8(7):e1002799.
2012: Maria Pilar Aoki; Eugenio Antonio Carrera-Silva; Henar Cuervo; Manuel Fresno; Núria Gironès; Susana Gea
Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection.
Journal of parasitology research 2012;2012():737324.
2011: Henar Cuervo; Patrick De Baetselier; Alain Beschin; Sofía Carbajosa; Núria Gironès; Néstor A Guerrero; Manuel Fresno
Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2656-65.
2011: Matilde Alique; Laura Calleros; Alicia Luengo; Mercedes Griera; Miguel Ángel Iñiguez; Carmen Punzón; Manuel Fresno; Manuel Rodríguez-Puyol; Diego Rodríguez-Puyol
Changes in extracellular matrix composition regulate cyclooxygenase-2 expression in human mesangial cells.
American journal of physiology. Cell physiology 2011;300(4):C907-18.
2011: JAVIER Carrión; Cristina Folgueira; Manuel Fresno; Manuel Soto; Jose M Requena
Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation.
Parasites & vectors 2011;4():150.
2011: Susana Alvarez; Almudena Blanco; Manuel Fresno; Ma Ángeles Muñoz-Fernández
TNF-α contributes to caspase-3 independent apoptosis in neuroblastoma cells: role of NFAT.
PloS one 2011;6(1):e16100.
2010: Aranzazu Cruz-Adalia; Luis Jesús Jiménez-Borreguero; Marta Ramírez-Huesca; Isabel Chico-Calero; Olga Barreiro; Erica López-Conesa; Manuel Fresno; Francisco Sánchez-Madrid; Pilar Martín
CD69 limits the severity of cardiomyopathy after autoimmune myocarditis.
Circulation 2010;122(14):1396-404.
2010: Miguel A Iñiguez; Carmen Punzón; Cristina Cacheiro-Llaguno; Manuel D Díaz-Muñoz; Javier Duque; Rosa Cuberes; Inés Alvarez; Eva M Andrés; Jordi Buxens; Helmut Buschmann; José M Vela; Manuel Fresno
Cyclooxygenase-independent inhibitory effects on T cell activation of novel 4,5-dihydro-3 trifluoromethyl pyrazole cyclooxygenase-2 inhibitors.
International immunopharmacology 2010;10(10):1295-304.
2010: Manuel D Díaz-Muñoz; Inés C Osma-García; Cristina Cacheiro-Llaguno; Manuel Fresno; Miguel A Iñiguez
Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages.
Cellular signalling 2010;22(10):1427-36.
2010: Erika Terzuoli; Sandra Donnini; Antonio Giachetti; Miguel A Iñiguez; Manuel Fresno; Giovanni Melillo; Marina Ziche
Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(16):4207-16.
2010: Susana Alvarez; Almudena Blanco; Manuel Fresno; M Angeles Muñoz-Fernández
Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity.
Journal of neurochemistry 2010;113(3):772-83.
2010: Pilar Alcaide; Yaw Chin Lim; Francis W Luscinskas; Manuel Fresno
Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.
Infection and immunity 2010;78(3):1260-8.
2010: Almudena Blanco; Susana Alvarez; Manuel Fresno; Maria Ángeles Muñoz-Fernández
Amyloid-β induces cyclooxygenase-2 and PGE2 release in human astrocytes in NF-κ B dependent manner.
Journal of Alzheimer's disease : JAD 2010;22(2):493-505.
2009: Javier Santos; Laura González-Sánchez; María Matabuena-Deyzaguirre; María Villa-Morales; Patricia Cozar; P López-Nieva; Pablo Fernández-Navarro; Manuel Fresno; Manuel D Díaz-Muñoz; Jean Louis GUENET; Xavier Montagutelli; José Fernández-Piqueras
A role for stroma-derived annexin A1 as mediator in the control of genetic susceptibility to T-cell lymphoblastic malignancies through prostaglandin E2 secretion.
Cancer research 2009;69(6):2577-87.
2009: Ma Isabel Clemente; Susana Alvarez; Ma Jesús Serramía; Ombretta Turriziani; Miguel Genebat; Manuel Leal; Manuel Fresno; M Angeles Muñoz-Fernández
Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4.
Antiviral therapy 2009;14(8):1101-11.
2009: Aitor G Granja; Elena G Sánchez; Prado Sabina; Manuel Fresno; Yolanda Revilla
African swine fever virus blocks the host cell antiviral inflammatory response through a direct inhibition of PKC-theta-mediated p300 transactivation.
Journal of virology 2009;83(2):969-80.
2008: Alicia M Hidalgo-Estévez; Carmen Punzón; Gonzalo Sanchez-Duffhues; Eduardo Muñoz; Manuel Fresno
HIV-1-Tat potentiates CXCL12/stromal cell-derived factor 1-induced downregulation of membrane CXCR4 in T lymphocytes through protein kinase C zeta.
Molecular immunology 2008;46(1):106-15.
2008: Susana Alvarez; Almudena Blanco; Florian Kern; Manuel Fresno; Ma Angeles Muñoz-Fernández
HIV-2 induces NF-kappaB activation and cyclooxygenase-2 expression in human astroglial cells.
Virology 2008;380(1):144-51.
2008: Virginia Vila-del Sol; Carmen Punzón; Manuel Fresno
IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4461-70.
2008: Elena Maganto-Garcia; Carmen Punzon; Cox Terhorst; Manuel Fresno
Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophages.
Traffic (Copenhagen, Denmark) 2008;9(8):1299-315.
2008: Miguel A Iñiguez; Cristina Cacheiro-Llaguno; Natalia Cuesta; Manuel D Díaz-Muñoz; Manuel Fresno
Prostanoid function and cardiovascular disease.
Archives of physiology and biochemistry 2008;114(3):201-9.
2008: Henar Cuervo; Miguel A Pineda; M Pilar Aoki; Susana Gea; Manuel Fresno; Núria Gironès
Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages.
The Journal of infectious diseases 2008;197(12):1772-82.
2008: Raquel Grau; Manuel D Díaz-Muñoz; Cristina Cacheiro-Llaguno; Manuel Fresno; Miguel A Iñiguez
Role of peroxisome proliferator-activated receptor alpha in the control of cyclooxygenase 2 and vascular endothelial growth factor: involvement in tumor growth.
PPAR research 2008;2008():352437.
2008: Almudena Blanco; Susana Alvarez; Manuel Fresno; M Angeles Muñoz-Fernández
Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):530-40.
2007: Andrea Pellegrini; Natalia Guinazu; Maria Pilar Aoki; Isabel Chico Calero; Eugenio Antonio Carrera-Silva; Nuria Girones; Manuel Fresno; Susana Gea
Spleen B cells from BALB/c are more prone to activation than spleen B cells from C57BL/6 mice during a secondary immune response to cruzipain.
International immunology 2007;19(12):1395-402.
2007: Natalia Guinazu; Andrea Pellegrini; Eugenio Antonio Carrera-Silva; Maria Pilar Aoki; Ana Maria Cabanillas; Nuria Gìronés; Manuel Fresno; Roxana Cano; Susana Gea
Immunisation with a major Trypanosoma cruzi antigen promotes pro-inflammatory cytokines, nitric oxide production and increases TLR2 expression.
International journal for parasitology 2007;37(11):1243-54.
2007: Elena Gómez-Casero; Belén San-Antonio; Miguel A Iñiguez; Manuel Fresno
Cot/Tpl2 and PKCzeta cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain.
Cellular signalling 2007;19(8):1652-61.
2007: Núria Gironès; Eugenio Carrasco-Marin; Henar Cuervo; nestor guerrero; cristina sanoja; Sparrow John; Reyes Flores-Herráez; Lorena Fernández-Prieto; Isabel Chico-Calero; Hugo Salgado; JAVIER Carrión; Manuel Fresno
Role of Trypanosoma cruzi autoreactive T cells in the generation of cardiac pathology.
Annals of the New York Academy of Sciences 2007;1107():434-44.
2007: Núria Gironès; M Adela Valero; Maria A García-Bodelón; Isabel Chico-Calero; Carmen Punzón; Manuel Fresno; Santiago Mas-Coma
Immune suppression in advanced chronic fascioliasis: an experimental study in a rat model.
The Journal of infectious diseases 2007;195(10):1504-12.
2007: Laura Diaz Muñoz; M Jesús Serramía; Manuel Fresno; M Angeles Muñoz-Fernández
Progesterone inhibits HIV-1 replication in human trophoblast cells through inhibition of autocrine tumor necrosis factor secretion.
The Journal of infectious diseases 2007;195(9):1294-302.
2007: Emma Castro; Nuria Gironés; José Luis Bueno; JAVIER Carrión; Lily Lin; Manuel Fresno
The efficacy of photochemical treatment with amotosalen HCl and ultraviolet A (INTERCEPT) for inactivation of Trypanosoma cruzi in pooled buffy-coat platelets.
Transfusion 2007;47(3):434-41.
2007: Carmen Sánchez-Valdepeñas; Carmen Punzón; Belén San-Antonio; Angel Martin; Manuel Fresno
Differential regulation of p65 and c-Rel NF-kappaB transactivating activity by Cot, protein kinase C zeta and NIK protein kinases in CD3/CD28 activated T cells.
Cellular signalling 2007;19(3):528-37.
2007: Ricardo S Corral; Miguel A Iñiguez; Javier Duque; R López-Pérez; Manuel Fresno
Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells.
Oncogene 2007;26(7):958-69.
2007: Susana Alvarez; M Jesús Serramía; Manuel Fresno; M Angeles Muñoz-Fernández
HIV-1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in astrocytoma cells through a nuclear factor-kappaB-dependent mechanism.
Neuromolecular medicine 2007;9(2):179-93.
2007: Virginia Vila-del Sol; Manuel D Díaz-Muñoz; Manuel Fresno
Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages.
Journal of leukocyte biology 2007;81(1):272-83.
2006: N Gironés; José Luis Bueno; JAVIER Carrión; Manuel Fresno; E Castro
The efficacy of photochemical treatment with methylene blue and light for the reduction of Trypanosoma cruzi in infected plasma.
Vox sanguinis 2006;91(4):285-91.
2006: Aitor G Granja; Prado Sabina; María L Salas; Manuel Fresno; Yolanda Revilla
Regulation of inducible nitric oxide synthase expression by viral A238L-mediated inhibition of p65/RelA acetylation and p300 transactivation.
Journal of virology 2006;80(21):10487-96.
2006: Javier Duque; Manuel D Díaz-Muñoz; Manuel Fresno; Miguel A Iñiguez
Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells.
Cellular signalling 2006;18(8):1262-9.
2006: Carmen del Aguila; Fernando Izquierdo; Aitor G Granja; Carolina Hurtado; Soledad Fenoy; Manuel Fresno; Yolanda Revilla
Encephalitozoon microsporidia modulates p53-mediated apoptosis in infected cells.
International journal for parasitology 2006;36(8):869-76.
2006: Alicia M Hidalgo-Estévez; Esther González; Carmen Punzón; Manuel Fresno
Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells.
The Journal of general virology 2006;87(Pt 6):1603-12.
2006: Arántzazu Alfranca; Miguel A Iñiguez; Manuel Fresno; Juan Miguel Redondo
Prostanoid signal transduction and gene expression in the endothelium: role in cardiovascular diseases.
Cardiovascular research 2006;70(3):446-56.
2006: Carmen Sánchez-Valdepeñas; Angel G Martín; Parameswaran Ramakrishnan; David Wallach; Manuel Fresno
NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4666-74.
2006: Raquel Grau; Carmen Punzón; Manuel Fresno; Miguel A Iñiguez
Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1.
The Biochemical journal 2006;395(1):81-8.
2006: Aitor G Granja; María L Nogal; Carolina Hurtado; Carmen del Aguila; Angel L Carrascosa; María L Salas; Manuel Fresno; Yolanda Revilla
The viral protein A238L inhibits TNF-alpha expression through a CBP/p300 transcriptional coactivators pathway.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):451-62.
2005: Susana Alvarez; M Jesús Serramía; Manuel Fresno; M Angeles Muñoz-Fernández
Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism.
Journal of neurochemistry 2005;94(3):850-61.
2005: Javier Duque; Manuel Fresno; Miguel A Iñiguez
Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2.
The Journal of biological chemistry 2005;280(10):8686-93.
2005: Virginia Vila-del Sol; Manuel Fresno
Involvement of TNF and NF-kappa B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2825-33.
2005: Núria Gironès; H Cuervo; Manuel Fresno
Trypanosoma cruzi-induced molecular mimicry and Chagas' disease.
Current topics in microbiology and immunology 2005;296():89-123.
2004: Aitor G Granja; María L Nogal; Carolina Hurtado; Virginia Vila-del Sol; Angel L Carrascosa; María L Salas; Manuel Fresno; Yolanda Revilla
The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway.
The Journal of biological chemistry 2004;279(51):53736-46.
2004: José L Jimenez; Miguel A Iñiguez; M Angeles Muñoz-Fernández; Manuel Fresno
Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes.
Cellular signalling 2004;16(12):1363-73.
2004: Pilar Alcaide; Manuel Fresno
The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin.
International immunology 2004;16(10):1365-75.
2004: Raquel Grau; Miguel A Iñiguez; Manuel Fresno
Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism.
Cancer research 2004;64(15):5162-71.
2004: Pilar Alcaide; Manuel Fresno
AgC10, a mucin from Trypanosoma cruzi, destabilizes TNF and cyclooxygenase-2 mRNA by inhibiting mitogen-activated protein kinase p38.
European journal of immunology 2004;34(6):1695-704.
2003: Clara I Rodríguez; Núria Gironès; Manuel Fresno
Cha, a basic helix-loop-helix transcription factor involved in the regulation of upstream stimulatory factor activity.
The Journal of biological chemistry 2003;278(44):43135-45.
2003: C Domingo; Ignacio Gadea; Mercedes Pardeiro; C Castilla; S Fernández; M A Fernández-Clua; Juan J de la Cruz-Troca; Carmen Punzón; Francisco Soriano; Manuel Fresno; Enrique Tabarés
Immunological properties of a DNA plasmid encoding a chimeric protein of herpes simplex virus type 2 glycoprotein B and glycoprotein D.
Vaccine 2003;21(25-26):3565-74.
2003: Carmen Punzón; Antonio Alcaide; Manuel Fresno
In vitro anti-inflammatory activity of Phlebodium decumanum. Modulation of tumor necrosis factor and soluble TNF receptors.
International immunopharmacology 2003;3(9):1293-9.
2003: Miguel A Iñiguez; Antonio Rodríguez; Olga V Volpert; Manuel Fresno; Juan Miguel Redondo
Cyclooxygenase-2: a therapeutic target in angiogenesis.
Trends in molecular medicine 2003;9(2):73-8.
2003: Núria Gironès; Manuel Fresno
Etiology of Chagas disease myocarditis: autoimmunity, parasite persistence, or both?
Trends in parasitology 2003;19(1):19-22.
2002: Iñigo Angulo; Manuel Fresno
Cytokines in the pathogenesis of and protection against malaria.
Clinical and diagnostic laboratory immunology 2002;9(6):1145-52.
2002: Ana I Rico; Núria Gironès; Manuel Fresno; Carlos Alonso; Jose M Requena
The heat shock proteins, Hsp70 and Hsp83, of Leishmania infantum are mitogens for mouse B cells.
Cell stress & chaperones 2002;7(4):339-46.
2002: Oscar Goñi; Pilar Alcaide; Manuel Fresno
Immunosuppression during acute Trypanosoma cruzi infection: involvement of Ly6G (Gr1(+))CD11b(+ )immature myeloid suppressor cells.
International immunology 2002;14(10):1125-34.
2002: Belén San-Antonio; Miguel A Iñiguez; Manuel Fresno
Protein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activity.
The Journal of biological chemistry 2002;277(30):27073-80.
2002: Iñigo Angulo; María Belén Jiménez-Díaz; José Francisco García-Bustos; Domingo Gargallo; Federico Gómez de las Heras; M Angeles Muñoz-Fernández; Manuel Fresno
Candida albicans infection enhances immunosuppression induced by cyclophosphamide by selective priming of suppressive myeloid progenitors for NO production.
Cellular immunology 2002;218(1-2):46-58.
2002: Carmen Punzón; Salvador Resino; José M Bellón; M Angeles Muñoz-Fernández; Manuel Fresno
Analysis of the systemic immune response in HIV-1-infected patients suffering from opportunistic Candida infection.
European cytokine network 2002;13(2):215-23.
2002: Clara I Rodríguez; María L Nogal; Angel L Carrascosa; María L Salas; Manuel Fresno; Yolanda Revilla
African swine fever virus IAP-like protein induces the activation of nuclear factor kappa B.
Journal of virology 2002;76(8):3936-42.
2001: Núria Gironès; Clara I Rodríguez; Beatriz Basso; José Ma Bellon; Salvador Resino; M Angeles Muñoz-Fernández; Susana Gea; Edgardo Moretti; Manuel Fresno
Antibodies to an epitope from the Cha human autoantigen are markers of Chagas' disease.
Clinical and diagnostic laboratory immunology 2001;8(6):1039-43.
2001: José L Jimenez; Carmen Punzón; J Navarro; M Angeles Muñoz-Fernández; Manuel Fresno
Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappaB and nuclear factor of activated T cells activation.
The Journal of pharmacology and experimental therapeutics 2001;299(2):753-9.
2001: Pedro Bonay; R Molina; Manuel Fresno
Binding specificity of mannose-specific carbohydrate-binding protein from the cell surface of Trypanosoma cruzi.
Glycobiology 2001;11(9):719-29.
2001: R de Gregorio; Miguel A Iñiguez; Manuel Fresno; Susana Alemany
Cot kinase induces cyclooxygenase-2 expression in T cells through activation of the nuclear factor of activated T cells.
The Journal of biological chemistry 2001;276(29):27003-9.
2001: J González-Nicolás; Salvador Resino; José Luis Jiménez; Susana Alvarez; Manuel Fresno; M Angeles Muñoz-Fernández
Tumor necrosis factor-alpha and nitric oxide in vertically HIV-1-infected children: implications for pathogenesis.
European cytokine network 2001;12(3):437-44.
2001: Angel Martin; Belén San-Antonio; Manuel Fresno
Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha.
The Journal of biological chemistry 2001;276(19):15840-9.
2001: José Luis Jiménez; J González-Nicolás; Susana Alvarez; Manuel Fresno; M Angeles Muñoz-Fernández
Regulation of human immunodeficiency virus type 1 replication in human T lymphocytes by nitric oxide.
Journal of virology 2001;75(10):4655-63.
2001: Núria Gironès; Clara I Rodríguez; E Carrasco-Marín; R F Hernáez; J L de Rego; Manuel Fresno
Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease.
The Journal of clinical investigation 2001;107(8):985-93.
2001: E González; Carmen Punzón; M González; Manuel Fresno
HIV-1 Tat inhibits IL-2 gene transcription through qualitative and quantitative alterations of the cooperative Rel/AP1 complex bound to the CD28RE/AP1 composite element of the IL-2 promoter.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4560-9.
2001: G L Hernández; Olga V Volpert; Miguel A Iñiguez; Encarnación Lorenzo; Sara Martínez-Martínez; Raquel Grau; Manuel Fresno; Juan Miguel Redondo
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2.
The Journal of experimental medicine 2001;193(5):607-20.
2000: Fuencisla Matesanz; Concepción Delgado; Manuel Fresno; Antonio Alcina
Allelic selection of human IL-2 gene.
European journal of immunology 2000;30(12):3516-21.
2000: Laura Giordanengo; C Maldonado; Héctor W Rivarola; D Iosa; N Girones; Manuel Fresno; Susana Gea
Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring.
European journal of immunology 2000;30(11):3181-9.
2000: P B Miarons; Manuel Fresno
Lectins from tropical sponges. Purification and characterization of lectins from genus Aplysina.
The Journal of biological chemistry 2000;275(38):29283-9.
2000: Angel Martin; Manuel Fresno
Tumor necrosis factor-alpha activation of NF-kappa B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel.
The Journal of biological chemistry 2000;275(32):24383-91.
2000: Miguel A Iñiguez; S Martinez-Martinez; Carmen Punzón; Juan Miguel Redondo; Manuel Fresno
An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes.
The Journal of biological chemistry 2000;275(31):23627-35.
2000: Luis F García-Fernández; Miguel A Iñiguez; N Eguchi; Manuel Fresno; Y Urade; Alberto Muñoz
Dexamethasone induces lipocalin-type prostaglandin D synthase gene expression in mouse neuronal cells.
Journal of neurochemistry 2000;75(2):460-70.
2000: Iñigo Angulo; Federico Gómez de las Heras; J F García-Bustos; D Gargallo; M Angeles Muñoz-Fernández; Manuel Fresno
Nitric oxide-producing CD11b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice.
Blood 2000;95(1):212-20.
1999: E Obregón; Carmen Punzón; Eduardo Fernández-Cruz; Manuel Fresno; M Angeles Muñoz-Fernández
HIV-1 infection induces differentiation of immature neural cells through autocrine tumor necrosis factor and nitric oxide production.
Virology 1999;261(2):193-204.
1999: Miguel A Iñiguez; Carmen Punzón; Manuel Fresno
Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):111-9.
1999: Esperanza Rodríguez; Pedro Bonay; Manuel Fresno; Teresa Gárate
Cloning and characterization of Rab and Ran/TC4 cDNA clones in Trichinella spp.
Parasitology research 1999;85(7):607-11.
1999: Pedro Bonay; Manuel Fresno
Isolation and purification of a neutral alpha(1,2)-mannosidase from Trypanosoma cruzi.
Glycobiology 1999;9(5):423-33.
1999: T Laín de Lera; Lola Folgueira; A G Martín; C Dargemont; MA Pedraza; Mercedes Bermejo; Pedro Bonay; Manuel Fresno; J Alcami
Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes.
Oncogene 1999;18(8):1581-8.
1998: S Larrucea; Carolina González-Rubio; Rosario Cambronero; B Ballou; Pedro Bonay; Eduardo López-Granados; Philippe Bouvet; Gumersindo Fontán; Manuel Fresno; Margarita López-Trascasa
Cellular adhesion mediated by factor J, a complement inhibitor. Evidence for nucleolin involvement.
The Journal of biological chemistry 1998;273(48):31718-25.
1998: Pedro Bonay; I Durán-Chica; Manuel Fresno; Balbino Alarcon; Antonio Alcina
Antiparasitic effects of the intra-Golgi transport inhibitor megalomicin.
Antimicrobial agents and chemotherapy 1998;42(10):2668-73.
1998: G M Bertot; Ricardo S Corral; Manuel Fresno; C Rodríguez; A M Katzin; S Grinstein
Trypanosoma cruzi tubulin eliminated in the urine of the infected host.
The Journal of parasitology 1998;84(3):608-14.
1998: J Navarro; Carmen Punzón; José Luis Jiménez; Eduardo Fernández-Cruz; A Pizarro; Manuel Fresno; M Angeles Muñoz-Fernández
Inhibition of phosphodiesterase type IV suppresses human immunodeficiency virus type 1 replication and cytokine production in primary T cells: involvement of NF-kappaB and NFAT.
Journal of virology 1998;72(6):4712-20.
1998: Yolanda Revilla; M Callejo; Javier M Rodríguez; E Culebras; María L Nogal; María L Salas; E Viñuela; Manuel Fresno
Inhibition of nuclear factor kappaB activation by a virus-encoded IkappaB-like protein.
The Journal of biological chemistry 1998;273(9):5405-11.
1997: M Angeles Muñoz-Fernández; J Navarro; A Garcia; Carmen Punzón; Eduardo Fernández-Cruz; Manuel Fresno
Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation.
The Journal of allergy and clinical immunology 1997;100(6 Pt 1):838-45.
1997: JA de Diego; Carmen Punzón; M Duarte; Manuel Fresno
Alteration of macrophage function by a Trypanosoma cruzi membrane mucin.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4983-9.
1997: Pedro Bonay; J Solís; H de la Calle; Manuel Fresno; A Grubb; Enrique Méndez
Massive glycation of protein HC, a low molecular weight lipocalin, in non-diabetic individuals.
FEBS letters 1997;416(3):276-80.
1997: Pedro Bonay; Manuel Fresno; Balbino Alarcon
Megalomicin disrupts lysosomal functions.
Journal of cell science 1997;110 ( Pt 16)():1839-49.
1997: E Obregón; M C Punzón; J González-Nicolás; E Fernandez-Cruz; Manuel Fresno; M Angeles Muñoz-Fernández
Induction of adhesion/differentiation of human neuroblastoma cells by tumour necrosis factor-alpha requires the expression of an inducible nitric oxide synthase.
The European journal of neuroscience 1997;9(6):1184-93.
1997: J Gómez; A García; L R-Borlado; Pedro Bonay; C Martínez-A; Augusto Silva; Manuel Fresno; Ana Carrera; C Eicher-Streiber; A Rebollo
IL-2 signaling controls actin organization through Rho-like protein family, phosphatidylinositol 3-kinase, and protein kinase C-zeta.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1516-22.
1996: María J Bullido; M A Muñoz-Fernandez; María Recuero; Manuel Fresno; Fernando Valdivieso
Alzheimer's amyloid precursor protein is expressed on the surface of hematopoietic cells upon activation.
Biochimica et biophysica acta 1996;1313(1):54-62.
1996: J Navarro; M C Punzón; Angel Pizarro; Eduardo Fernández-Cruz; Manuel Fresno; M Angeles Muñoz-Fernández
Pentoxifylline inhibits acute HIV-1 replication in human T cells by a mechanism not involving inhibition of tumour necrosis factor synthesis or nuclear factor-kappa B activation.
AIDS (London, England) 1996;10(5):469-75.
1996: Pedro Bonay; S Munro; Manuel Fresno; Balbino Alarcon
Intra-Golgi transport inhibition by megalomicin.
The Journal of biological chemistry 1996;271(7):3719-26.
1995: J Gómez; A Martínez de Aragón; Pedro Bonay; C Pitton; A García; A Silva; Manuel Fresno; F Alvarez; Angelita Rebollo
Physical association and functional relationship between protein kinase C zeta and the actin cytoskeleton.
European journal of immunology 1995;25(9):2673-8.
1995: Pedro Bonay; Manuel Fresno
Characterization of carbohydrate binding proteins in Trypanosoma cruzi.
The Journal of biological chemistry 1995;270(19):11062-70.
1995: A Salmerón; A Borroto; Manuel Fresno; M J Crumpton; Steven C Ley; Balbino Alarcon
Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1675-83.
1995: F X Pimentel-Muiños; J Mazana; Manuel Fresno
Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha.
European journal of immunology 1995;25(1):179-86.
1994: F X Pimentel-Muiños; J Mazana; Manuel Fresno
Regulation of interleukin-2 receptor alpha chain expression and nuclear factor.kappa B activation by protein kinase C in T lymphocytes. Autocrine role of tumor necrosis factor alpha.
The Journal of biological chemistry 1994;269(39):24424-9.
1994: J Navarro; Angel Pizarro; Eduardo Fernández-Cruz; Manuel Fresno; M Angeles Muñoz-Fernández
Pentoxifylline preferentially inhibits interleukin-10 production by HIV-1-infected human T cells.
AIDS (London, England) 1994;8(8):1192-4.
1994: F X Pimentel-Muiños; M Angeles Muñoz-Fernández; Manuel Fresno
Control of T lymphocyte activation and IL-2 receptor expression by endogenously secreted lymphokines.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5714-22.
1994: M Angeles Muñoz-Fernández; Eva Cano; Catherine A O'Donnell; J Doyle; Foo Y Liew; Manuel Fresno
Tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin-6 but not TNF-beta induce differentiation of neuroblastoma cells: the role of nitric oxide.
Journal of neurochemistry 1994;62(4):1330-6.
1994: Manuel Fresno; C Hernández-Munaín; JA de Diego; L Rivas; J Scharfstein; Pedro Bonay
Trypanosoma cruzi: identification of a membrane cysteine proteinase linked through a GPI anchor.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):431-7.
1993: M Angeles Muñoz-Fernández; Manuel Fresno
Involvement of nitric oxide on the cytokine induced growth of glial cell.
Biochemical and biophysical research communications 1993;194(1):319-25.
1993: M A Fernández; M Angeles Muñoz-Fernández; Manuel Fresno
Involvement of beta 1 integrins in the binding and entry of Trypanosoma cruzi into human macrophages.
European journal of immunology 1993;23(2):552-7.
1993: C Hernández-Munaín; J L De Diego; Pedro Bonay; N Gironés; Manuel Fresno
GP 50/55, a membrane antigen of Trypanosoma cruzi involved in autoimmunity and immunosuppression.
Biological research 1993;26(1-2):209-18.
1992: F X Pimentel-Muiños; J A Lopez-Guerrero; Manuel Fresno; Miguel A Alonso
CD4 gene transcription is transiently repressed during differentiation of myeloid cells to macrophage-like cells.
European journal of biochemistry / FEBS 1992;207(1):321-5.
1992: Eva Cano; M Angeles Muñoz-Fernández; Manuel Fresno
Regulation of interleukin-2 responses by phosphatidic acid.
European journal of immunology 1992;22(7):1883-9.
1992: M Angeles Muñoz-Fernández; F X Pimentel-Muiños; A González; F Gambon; L Alvarez-Vallina; Manuel Fresno
Differential effect of tumour necrosis factor on human thymocyte subpopulations.
Immunology 1992;76(3):439-45.
1992: A Mallabiabarrena; Manuel Fresno; Balbino Alarcon
An endoplasmic reticulum retention signal in the CD3 epsilon chain of the T-cell receptor.
Nature 1992;357(6379):593-6.
1992: C Hernández-Munaín; J L De Diego; Antonio Alcina; Manuel Fresno
A Trypanosoma cruzi membrane protein shares an epitope with a lymphocyte activation antigen and induces crossreactive antibodies.
The Journal of experimental medicine 1992;175(6):1473-82.
1992: M Angeles Muñoz-Fernández; M A Fernández; Manuel Fresno
Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-alpha and IFN-gamma through a nitric oxide-dependent mechanism.
Immunology letters 1992;33(1):35-40.
1992: M Angeles Muñoz-Fernández; M A Fernández; Manuel Fresno
Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism.
European journal of immunology 1992;22(2):301-7.
1991: M R Campanero; R Pulido; J L Alonso; J P Pivel; F X Pimentel-Muiños; Manuel Fresno; Francisco Sánchez-Madrid
Down-regulation by tumor necrosis factor-alpha of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism.
European journal of immunology 1991;21(12):3045-8.
1991: A Salmerón; Francisco Sánchez-Madrid; M A Ursa; Manuel Fresno; Balbino Alarcon
A conformational epitope expressed upon association of CD3-epsilon with either CD3-delta or CD3-gamma is the main target for recognition by anti-CD3 monoclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(9):3047-52.
1991: J A López-Guerrero; Francisco Martinez-Abarca; Manuel Fresno; Luis Carrasco; Miguel A Alonso
Cell type determines the relative proportions of (-) and (+) strand RNA during poliovirus replication.
Virus research 1991;20(1):23-9.
1991: M Angeles Muñoz-Fernández; R Armas-Portela; JAVIER DIAZ-NIDO; J L Alonso; Manuel Fresno; Jesús Avila
Differential effects of tumor necrosis factor on the growth and differentiation of neuroblastoma and glioma cells.
Experimental cell research 1991;194(1):161-4.
1991: Balbino Alarcon; Steven C Ley; F Sánchez-Madrid; Richard S Blumberg; S T Ju; Manuel Fresno; Cox Terhorst
The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.
The EMBO journal 1991;10(4):903-12.
1991: C Hernández-Munaín; M A Fernández; Antonio Alcina; Manuel Fresno
Characterization of a glycosyl-phosphatidylinositol-anchored membrane protein from Trypanosoma cruzi.
Infection and immunity 1991;59(4):1409-16.
1991: J A López-Guerrero; Carlos Cabañas; Carmelo Bernabeu; Manuel Fresno; Miguel A Alonso
Effects of poliovirus replication on undifferentiated and differentiated monocytic U937 cells: comparative studies with human macrophages.
Intervirology 1991;32(3):137-48.
1990: J A López-Guerrero; F X Pimentel-Muiños; Manuel Fresno; Miguel A Alonso
Role of soluble cytokines on the restricted replication of poliovirus in the monocytic U937 cell line.
Virus research 1990;16(2):225-30.
1990: Eva Cano; Angel Pizarro; Juan Miguel Redondo; Francisco Sánchez-Madrid; Carmelo Bernabeu; Manuel Fresno
Induction of T cell activation by monoclonal antibodies specific for the transferrin receptor.
European journal of immunology 1990;20(4):765-70.
1990: M Angeles Muñoz-Fernández; F X Pimentel-Muiños; Miguel A Alonso; M Campanero; Francisco Sánchez-Madrid; Augusto Silva; J L Alonso; Manuel Fresno
Synergy of tumor necrosis factor with protein kinase C activators on T cell activation.
European journal of immunology 1990;20(3):605-10.
1989: J A López-Guerrero; Luis Carrasco; Francisco Martinez-Abarca; Manuel Fresno; Miguel A Alonso
Restriction of poliovirus RNA translation in a human monocytic cell line.
European journal of biochemistry / FEBS 1989;186(3):577-82.
1989: J A López-Guerrero; Carlos Cabañas; Carmelo Bernabeu; Manuel Fresno; Miguel A Alonso
Poliovirus infection interferes with the phorbol ester-induced differentiation of the monocytic U937 cell line.
Virus research 1989;14(1):65-72.
1989: J A Lopez Guerrero; Juan Miguel Redondo; Balbino Alarcon; Francisco Sánchez-Madrid; M Rodríguez Moya; M Ortíz de Landazuri; Carmelo Bernabeu; Manuel Fresno
Different functional domains on the transferrin receptor molecule defined by monoclonal antibodies.
Immunology 1989;66(2):252-7.
1988: Juan Miguel Redondo; Abelardo López-Rivas; V Vila; E J Cragoe; Manuel Fresno
The role of protein kinase C in T lymphocyte proliferation. Existence of protein kinase C-dependent and -independent pathways.
The Journal of biological chemistry 1988;263(33):17467-70.
1988: Antonio Alcina; Manuel Fresno
Early and late heat-induced proteins during Leishmania mexicana transformation.
Biochemical and biophysical research communications 1988;156(3):1360-7.
1988: Antonio Alcina; Alan Jeffrey Hargreaves; Jesús Avila; J E Hesketh; Manuel Fresno
The detection of a spectrin-like protein in Trypanosoma cruzi with a polyclonal antibody.
Cell biology international reports 1988;12(11):979-85.
1988: J A López-Guerrero; Balbino Alarcon; Manuel Fresno
Mechanism of recognition of herpes simplex virus type 1-infected cells by natural killer cells.
The Journal of general virology 1988;69 ( Pt 11)():2859-68.
1988: Juan Miguel Redondo; Manuel Fresno; Abelardo López-Rivas
Inhibition of interleukin 2-induced proliferation of cloned murine T cells by glucocorticoids. Possible involvement of an inhibitory protein.
European journal of immunology 1988;18(10):1555-9.
1988: Antonio Alcina; Manuel Fresno; Balbino Alarcon
Activity of P536, a UDP-glucose analog, against Trypanosoma cruzi.
Antimicrobial agents and chemotherapy 1988;32(9):1412-5.
1988: Antonio Alcina; Manuel Fresno
A tubulin-related 55 kilodalton surface antigen recognized by different Trypanosoma cruzi stage-specific monoclonal antibodies from infected mice.
Molecular and biochemical parasitology 1988;29(2-3):181-90.
1988: Balbino Alarcon; Juan Miguel Redondo; H Bugany; L Carrasco; Manuel Fresno
Inhibition of natural killer cytotoxicity by extracellular ppp(A2'p5')nA oligonucleotides.
International journal of immunopharmacology 1988;10(1):73-80.
1987: Antonio Alcina; Manuel Fresno
A colorimetric assay based on cell viability for the indirect detection of intracellular replication and killing of Trypanosoma cruzi.
Journal of immunological methods 1987;105(1):1-8.
1987: Antonio Alcina; Francisco Zafra; Cecilio Giménez; Manuel Fresno
Stimulation of the trypanocidal and endoribonuclease activities by the interferon induced (2'-5') oligoadenylates.
Molecular and biochemical parasitology 1987;26(1-2):113-9.
1987: Antonio Alcina; Manuel Fresno
Activation by synergism between endotoxin and lymphokines of the mouse macrophage cell line J774 against infection by Trypanosoma cruzi.
Parasite immunology 1987;9(2):175-86.
1987: J M Redondo; J A López-Guerrero; Manuel Fresno
Potentiation of interleukin-2 activity by levamisole and imidazole.
Immunology letters 1987;14(2):111-6.
1986: J M Redondo; Abelardo López-Rivas; Manuel Fresno
Activation of the Na+/K+-ATPase by interleukin-2.
FEBS letters 1986;206(2):199-202.
1986: Antonio Alcina; Alan Jeffrey Hargreaves; Jesús Avila; Manuel Fresno
A Trypanosoma cruzi monoclonal antibody that recognizes a superficial tubulin-like antigen.
Biochemical and biophysical research communications 1986;139(3):1176-83.
1985: Antonio Alcina; Manuel Fresno
Suppressor factor of T-cell activation and decreased interleukin 2 activity in experimental African trypanosomiasis.
Infection and immunity 1985;50(2):382-7.