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Massimo Fresta

Research Profile

Chemicals & Drugs

Anatomy

Procedures

Calorimetry, Differential Scanning

Living Beings

Rats
Mouse

Occupations

Chemistry, Pharmaceutical

Co-author Network

Publications

TOP 3
Donatella Paolino; Efisio Puxeddu; Diego Russo; Marilena Celano; Donato Cosco; Sonia Moretti; Massimo Fresta
Gemcitabine-loaded biocompatible nanocapsules for the effective treatment of human cancer.
Donatella Paolino; Christian Celia; Massimo Fresta; Gaetano Giammona; Mariano Licciardi; Gennara Cavallaro
Folate-targeted supramolecular vesicular aggregates as a new frontier for effective anticancer treatment in in vivo model.
Donatella Paolino; Elena Trapasso; Valeria M Morittu; Christian Celia; Felisa Cilurzo; Donato Cosco; Massimo Fresta
Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles.

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All Publications

2013: Donatella Paolino; Efisio Puxeddu; Diego Russo; Marilena Celano; Donato Cosco; Sonia Moretti; Massimo Fresta
Gemcitabine-loaded biocompatible nanocapsules for the effective treatment of human cancer.
Nanomedicine (London, England) 2013;8(2):193-201.
2012: Donatella Paolino; Christian Celia; Massimo Fresta; Gaetano Giammona; Mariano Licciardi; Gennara Cavallaro
Folate-targeted supramolecular vesicular aggregates as a new frontier for effective anticancer treatment in in vivo model.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;82(1):94-102.
2012: Donatella Paolino; Elena Trapasso; Valeria M Morittu; Christian Celia; Felisa Cilurzo; Donato Cosco; Massimo Fresta
Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles.
Journal of controlled release : official journal of the Controlled Release Society 2012;162(1):143-51.
2012: Donatella Paolino; Elena Trapasso; Christian Celia; Felisa Cilurzo; Massimo Fresta
Paclitaxel-loaded ethosomes®: potential treatment of squamous cell carcinoma, a malignant transformation of actinic keratoses.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;81(1):102-12.
2012: Christian Celia; Felisa Cilurzo; Donato Cosco; Massimo Fresta; Elena Trapasso; Donatella Paolino
Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders.
Biomedical microdevices 2012;14(1):119-30.
2012: Donato Cosco; Massimo Fresta; Flavio Rocco; Margherita Vono; Maurizio Ceruti; Donatella Paolino
Self-assembled squalenoyl-cytarabine nanostructures as a potent nanomedicine for treatment of leukemic diseases.
International journal of nanomedicine 2012;7():2535-46.
2011: Christian Celia; Donato Cosco; Donatella Paolino; Massimo Fresta
Gemcitabine-loaded innovative nanocarriers vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity.
Expert opinion on drug delivery 2011;8(12):1609-29.
2011: Donatella Paolino; Donato Cosco; Roberto Molinaro; Christian Celia; Massimo Fresta
Supramolecular devices to improve the treatment of brain diseases.
Drug discovery today 2011;16(7-8):311-24.
2010: Mariano Licciardi; Donatella Paolino; Christian Celia; Gaetano Giammona; Gennara Cavallaro; Massimo Fresta
Folate-targeted supramolecular vesicular aggregates based on polyaspartyl-hydrazide copolymers for the selective delivery of antitumoral drugs.
Biomaterials 2010;31(28):7340-54.
2010: Carlotta Marianecci; Donatella Paolino; Christian Celia; Massimo Fresta; m carafa; Franco Alhaique
Non-ionic surfactant vesicles in pulmonary glucocorticoid delivery: characterization and interaction with human lung fibroblasts.
Journal of controlled release : official journal of the Controlled Release Society 2010;147(1):127-35.
2010: Donatella Paolino; Donato Cosco; Leda Racanicchi; Elena Trapasso; Christian Celia; Michelangelo Iannone; Efisio Puxeddu; Giuseppe Costante; Sebastiano Filetti; Diego Russo; Massimo Fresta
Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(2):144-50.
2010: Michelangelo Iannone; Donato Cosco; Felisa Cilurzo; Christian Celia; Donatella Paolino; Vincenzo Mollace; Domenicantonio Rotiroti; Massimo Fresta
A novel animal model to evaluate the ability of a drug delivery system to promote the passage through the BBB.
Neuroscience letters 2010;469(1):93-6.
2009: Donato Cosco; D Caponio; C Celia; R Citraro; Rita Muzzalupo; Donatella Paolino; Nevio Picci; Massimo Fresta
Novel PEG-coated niosomes based on bola-surfactant as drug carriers for 5-fluorouracil.
Biomedical microdevices 2009;11(5):1115-25.
2009: Donato Cosco; Alessandra Bulotta; Monica Ventura; Christian Celia; Teresa Calimeri; Gino Perri; Donatella Paolino; Nicola Costa; Paola Neri; Pierosandro Tagliaferri; Pierfrancesco Tassone; Massimo Fresta
In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer.
Cancer chemotherapy and pharmacology 2009;64(5):1009-20.
2009: Christian Celia; Elena Trapasso; Donato Cosco; Donatella Paolino; Massimo Fresta
Turbiscan lab expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent.
Colloids and surfaces. B, Biointerfaces 2009;72(1):155-60.
2009: Rosario Pignatello; Donatella Paolino; V Pantò; V Pistară; M G Calvagno; D Russo; Giovanni Puglisi; Massimo Fresta
Lipoamino acid prodrugs of paclitaxel: synthesis and cytotoxicity evaluation on human anaplastic thyroid carcinoma cells.
Current cancer drug targets 2009;9(2):202-13.
2008: Marilena Celano; S Schenone; Donato Cosco; Michele Navarra; E Puxeddu; L Racanicchi; C Brullo; E Varano; Stefano Alcaro; Elisabetta Ferretti; G Botta; Sebastiano Filetti; Massimo Fresta; M Botta; Diego Russo
Cytotoxic effects of a novel pyrazolopyrimidine derivative entrapped in liposomes in anaplastic thyroid cancer cells in vitro and in xenograft tumors in vivo.
Endocrine-related cancer 2008;15(2):499-510.
2008: Christian Celia; Natalia Malara; Rosa Terracciano; Donato Cosco; Donatella Paolino; Massimo Fresta; Rocco Savino
Liposomal delivery improves the growth-inhibitory and apoptotic activity of low doses of gemcitabine in multiple myeloma cancer cells.
Nanomedicine : nanotechnology, biology, and medicine 2008;4(2):155-66.
2008: Donatella Paolino; Donato Cosco; Rita Muzzalupo; Elena Trapasso; Nevio Picci; Massimo Fresta
Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer.
International journal of pharmaceutics 2008;353(1-2):233-42.
2008: Christian Celia; Maria Grazia Calvagno; Donatella Paolino; Bulotta Stefania; Cinzia Anna Ventura; Diego Russo; Massimo Fresta
Improved in vitro anti-tumoral activity, intracellular uptake and apoptotic induction of gemcitabine-loaded pegylated unilamellar liposomes.
Journal of nanoscience and nanotechnology 2008;8(4):2102-13.
2008: Donatella Paolino; Donato Cosco; M Licciardi; Gaetano Giammona; Massimo Fresta; G Cavallaro
Polyaspartylhydrazide copolymer-based supramolecular vesicular aggregates as delivery devices for anticancer drugs.
Biomacromolecules 2008;9(4):1117-30.
2007: Donatella Paolino; Rita Muzzalupo; Antonio Ricciardi; Christian Celia; Nevio Picci; Massimo Fresta
In vitro and in vivo evaluation of Bola-surfactant containing niosomes for transdermal delivery.
Biomedical microdevices 2007;9(4):421-33.
2007: Stanislava Stosic-Grujicic; Ivana Cvetkovic; Katia Mangano; Massimo Fresta; Danijela Maksimovic-Ivanic; Ljubica Harhaji; Dusan Popadic; Miljana Momcilovic; Djordje Miljkovic; Joseph Kim; Yousef Al-Abed; Yousef Al Abed; Ferdinando Nicoletti
A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice.
The Journal of pharmacology and experimental therapeutics 2007;320(3):1038-49.
2006: Andrea Cappelli; Valter Travagli; Iacopo Zanardi; Maurizio Anzini; Gianluca Giorgi; Alessandro Donati; Marianna Aggravi; Mario Casolaro; Massimo Fresta; Eugenio Paccagnini; Francesco Makovec; Salvatore Vomero
Physicochemical and biopharmaceutical characterization of endo-2-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-1H-benz[e]isoindol-1-one (CR3124) a novel potent 5-HT3 receptor antagonist.
Journal of pharmaceutical sciences 2006;95(12):2706-21.
2005: Donatella Paolino; Giuseppe Lucania; Domenico Mardente; Franco Alhaique; Massimo Fresta
Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers.
Journal of controlled release : official journal of the Controlled Release Society 2005;106(1-2):99-110.
2005: Barbara Ruozi; Giovanni Tosi; Flavio Forni; Massimo Fresta; Maria Angela Vandelli
Atomic force microscopy and photon correlation spectroscopy: two techniques for rapid characterization of liposomes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2005;25(1):81-9.
2005: Francesco Castelli; Antonio Raudino; Massimo Fresta
A mechanistic study of the permeation kinetics through biomembrane models: gemcitabine-phospholipid bilayer interaction.
Journal of colloid and interface science 2005;285(1):110-7.
2004: Marilena Celano; Maria Grazia Calvagno; Bulotta Stefania; Donatella Paolino; Franco Arturi; Domenicantonio Rotiroti; Sebastiano Filetti; Massimo Fresta; Diego Russo
Cytotoxic effects of gemcitabine-loaded liposomes in human anaplastic thyroid carcinoma cells.
BMC cancer 2004;4():63.
2004: Donatella Paolino; Michelangelo Iannone; Venera Cardile; Marcella Renis; Giovanni Puglisi; Domenicantonio Rotiroti; Massimo Fresta
Tolerability and improved protective action of idebenone-loaded pegylated liposomes on ethanol-induced injury in primary cortical astrocytes.
Journal of pharmaceutical sciences 2004;93(7):1815-27.
2003: Andrea Cappelli; Gal la Pericot Mohr; Andrea Gallelli; Germano Giuliani; Maurizio Anzini; Salvatore Vomero; Massimo Fresta; Patrizia Porcu; Elisabetta Maciocco; Alessandra Concas; Giovanni Biggio; Alessandro Donati
Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands.
Journal of medicinal chemistry 2003;46(17):3568-71.
2003: Claudia Giannavola; Claudio Bucolo; Adriana Maltese; Donatella Paolino; Maria Angela Vandelli; Giovanni Puglisi; Vinecent H L Lee; Massimo Fresta
Influence of preparation conditions on acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability.
Pharmaceutical research 2003;20(4):584-90.
2002: Massimo Fresta; Salvatore Guccione; Andrea Rosario Beccari; Pio Maria Furneri; Giovanni Puglisi
Combining molecular modeling with experimental methodologies: mechanism of membrane permeation and accumulation of ofloxacin.
Bioorganic & medicinal chemistry 2002;10(12):3871-89.
2002: Donatella Paolino; Cinzia Anna Ventura; Steven Nisticò; Giovanni Puglisi; Massimo Fresta
Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability.
International journal of pharmaceutics 2002;244(1-2):21-31.
2002: Carolina Muscoli; Massimo Fresta; Venera Cardile; Maddalena Palumbo; Marcella Renis; Giovanni Puglisi; Donatella Paolino; Steven Nisticò; Domenicantonio Rotiroti; Vincenzo Mollace
Ethanol-induced injury in rat primary cortical astrocytes involves oxidative stress: effect of idebenone.
Neuroscience letters 2002;329(1):21-4.
2002: Stefano Alcaro; Cinzia Anna Ventura; Donatella Paolino; Danilo Battaglia; Francesco Ortuso; Luigi Cattel; Giovanni Puglisi; Massimo Fresta
Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes.
Bioorganic & medicinal chemistry letters 2002;12(12):1637-41.
2002: Maddalena Palumbo; Alessandra Russo; Venera Cardile; Marcella Renis; Donatella Paolino; Giovanni Puglisi; Massimo Fresta
Improved antioxidant effect of idebenone-loaded polyethyl-2-cyanoacrylate nanocapsules tested on human fibroblasts.
Pharmaceutical research 2002;19(1):71-8.
2001: Massimo Fresta; Giacomo Fontana; Claudio Bucolo; G Cavallaro; Gaetano Giammona; Giovanni Puglisi
Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir.
Journal of pharmaceutical sciences 2001;90(3):288-97.
2001: Cinzia Anna Ventura; Massimo Fresta; Donatella Paolino; S Pedotti; Antonino Corsaro; Giovanni Puglisi
Biomembrane model interaction and percutaneous absorption of papaverine through rat skin: effects of cyclodextrins as penetration enhancers.
Journal of drug targeting 2001;9(5):379-93.
2000: Pio Maria Furneri; Massimo Fresta; Giovanni Puglisi; Gianna Tempera
Ofloxacin-loaded liposomes: in vitro activity and drug accumulation in bacteria.
Antimicrobial agents and chemotherapy 2000;44(9):2458-64.
1999: Massimo Fresta; Giovanni Puglisi
Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes.
Pharmaceutical research 1999;16(12):1843-9.
1999: Massimo Fresta; Annamaria Panico; Claudio Bucolo; Claudia Giannavola; Giovanni Puglisi
Characterization and in-vivo ocular absorption of liposome-encapsulated acyclovir.
The Journal of pharmacy and pharmacology 1999;51(5):565-76.
1998: Massimo Fresta; Rosa Chillemi; santi spampinato; Sebastiano Sciuto; Giovanni Puglisi
Liposomal delivery of a 30-mer antisense oligodeoxynucleotide to inhibit proopiomelanocortin expression.
Journal of pharmaceutical sciences 1998;87(5):616-25.
1997: Massimo Fresta; Giovanni Puglisi
Survival rate improvement in a rat ischemia model by long circulating liposomes containing cytidine-5I-diphosphate choline.
Life sciences 1997;61(13):1227-35.
1996: Massimo Fresta; P M Furneri; E Mezzasalma; V M Nicolosi; Giovanni Puglisi
Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils.
Antimicrobial agents and chemotherapy 1996;40(12):2865-73.
1996: Massimo Fresta; Gennara Cavallaro; Gaetano Giammona; E Wehrli; Giovanni Puglisi
Preparation and characterization of polyethyl-2-cyanoacrylate nanocapsules containing antiepileptic drugs.
Biomaterials 1996;17(8):751-8.
1996: Rosario Pignatello; Valeria Sorrenti; G Spampinato; T Pecora; A Panico; Claudia Di Giacomo; Massimo Fresta; Angelo Vanella; Giovanni Puglisi
Synthesis and preliminary in vitro screening of lipophilic alpha, gamma-bis(amides) as potential prodrugs of methotrexate.
Anti-cancer drug design 1996;11(3):253-64.
1996: Antonino Villari; N Micali; Massimo Fresta; S Trusso; Giovanni Puglisi
Time-resolved fluorescence. An approach in protein analysis.
Advances in experimental medicine and biology 1996;398():739-47.
1996: Massimo Fresta; Giovanni Puglisi
Application of liposomes as potential cutaneous drug delivery systems. In vitro and in vivo investigation with radioactively labelled vesicles.
Journal of drug targeting 1996;4(2):95-101.
1995: Massimo Fresta; E Wehrli; Giovanni Puglisi
Enhanced therapeutic effect of cytidine-5'-diphosphate choline when associated with GM1 containing small liposomes as demonstrated in a rat ischemia model.
Pharmaceutical research 1995;12(11):1769-74.
1995: Massimo Fresta; Giovanni Puglisi; Gaetano Giammona; Gennara Cavallaro; N Micali; P M Furneri
Pefloxacine mesilate- and ofloxacin-loaded polyethylcyanoacrylate nanoparticles: characterization of the colloidal drug carrier formulation.
Journal of pharmaceutical sciences 1995;84(7):895-902.
1995: Massimo Fresta; Spadaro Angelo; G Cerniglia; I M Ropero; Giovanni Puglisi; P M Furneri
Intracellular accumulation of ofloxacin-loaded liposomes in human synovial fibroblasts.
Antimicrobial agents and chemotherapy 1995;39(6):1372-5.
1994: Massimo Fresta; Giovanni Puglisi; Claudia Di Giacomo; A Russo
Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion.
The Journal of pharmacy and pharmacology 1994;46(12):974-81.
1994: M A Vandelli; Massimo Fresta; Giovanni Puglisi; Flavio Forni
An interpretative analysis of the effect of the surfactants used for the preparation of polyalkylcyanoacrylate nanoparticles on the release process.
Journal of microencapsulation 1994;11(5):531-8.
1994: Antonino Villari; N Micali; Massimo Fresta; Giovanni Puglisi
Spectrofluorimetry at zero angle: determination of salicylic acid in an acetylsalicylic acid pharmaceutical formulation.
The Analyst 1994;119(7):1561-5.
1993: Giovanni Puglisi; Gaetano Giammona; Massimo Fresta; Bianca Carlisi; N Micali; Antonino Villari
Evaluation of polyalkylcyanoacrylate nanoparticles as a potential drug carrier: preparation, morphological characterization and loading capacity.
Journal of microencapsulation 1993;10(3):353-66.
1992: Antonino Villari; N Micali; Massimo Fresta; Giovanni Puglisi
Simultaneous spectrophotometric determination in solid phase of aspirin and its impurity salicylic acid in pharmaceutical formulations.
Journal of pharmaceutical sciences 1992;81(9):895-8.
1992: Giovanni Puglisi; Massimo Fresta; C La Rosa; Cinzia Anna Ventura; A M Panico; G Mazzone
Liposomes as a potential drug carrier for citicoline (CDP-choline) and the effect of formulation conditions on encapsulation efficiency.
Die Pharmazie 1992;47(3):211-5.