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Stefan Freund

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TOP 3
Manuela K Hospenthal; Stefan M V Freund; David Komander
Assembly, analysis and architecture of atypical ubiquitin chains.
Natalia von Muhlinen; Benjamin J Ravenhill; Trevor J Rutherford; Masato Akutsu; Stuart Bloor; Agnes Foeglein; Stefan M V Freund; David Komander; Felix Randow
An essential role for the ATG8 ortholog LC3C in antibacterial autophagy.
Maxime Veillette; Katsiaryna Bichel; Stefan M V Freund; Leo C James; Paulina Pawlica; Quang Toan Pham; Mélodie B Plourde; Carlos Reyes-Moreno; Lionel Berthoux
The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import.

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All Publications

2013: Manuela K Hospenthal; Stefan M V Freund; David Komander
Assembly, analysis and architecture of atypical ubiquitin chains.
Nature structural & molecular biology 2013;20(5):555-65.
2013: Natalia von Muhlinen; Benjamin J Ravenhill; Trevor J Rutherford; Masato Akutsu; Stuart Bloor; Agnes Foeglein; Stefan M V Freund; David Komander; Felix Randow
An essential role for the ATG8 ortholog LC3C in antibacterial autophagy.
Autophagy 2013;9(5):784-6.
2013: Maxime Veillette; Katsiaryna Bichel; Stefan M V Freund; Leo C James; Paulina Pawlica; Quang Toan Pham; Mélodie B Plourde; Carlos Reyes-Moreno; Lionel Berthoux
The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import.
Retrovirology 2013;10():25.
2012: Natalia von Muhlinen; Ágnes Foeglein; Benjamin J Ravenhill; Trevor J Rutherford; Masato Akutsu; Stuart Bloor; Stefan M V Freund; David Komander; Felix Randow
LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy.
Molecular cell 2012;48(3):329-42.
2012: Bernhard C Lechtenberg; Stefan M V Freund; James A Huntington
An ensemble view of thrombin allostery.
Biological chemistry 2012;393(9):889-98.
2012: Matthew E C Caines; Stefan M V Freund; Katsiaryna Bichel; William A McEwan; Amanda J Price; Greg J Towers; Brian J Willett; Leo C James
Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Nature structural & molecular biology 2012;19(4):411-6.
2012: Tobias Brandt; Stefan M V Freund; Daniel P Teufel; Fiona M Townsley; Dmitry B Veprintsev
Molecular basis for modulation of the p53 target selectivity by KLF4.
PloS one 2012;7(10):e48252.
2011: Aruna Sathyamurthy; Mark D Allen; Stefan M V Freund; Christopher M Johnson; Mark Bycroft
Structural basis of p63α SAM domain mutants involved in AEC syndrome.
The FEBS journal 2011;278(15):2680-8.
2011: Eviatar Natan; Cetin Baloglu; Kevin Pagel; Stefan M V Freund; Nina Morgner; Carol V Robinson; Alan R Fersht; Andreas C Joerger
Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer.
Journal of molecular biology 2011;409(3):358-68.
2011: Andrew J Finch; Christine Hilcenko; Nicolas Basse; Lesley F Drynan; Beatriz Goyenechea; Tobias F Menne; Africa González Fernández; Paul Simpson; Clive S D'Santos; Mark J Arends; jean donadieu; Christine Bellanné-Chantelot; Michael Costanzo; Charles Boone; Andrew N McKenzie; Stefan M V Freund; Alan J Warren
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Genes & development 2011;25(9):917-29.
2010: Bernhard C Lechtenberg; Daniel J D Johnson; Stefan M V Freund; James A Huntington
NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14087-92.
2010: Anja Bremm; Stefan M V Freund; David Komander
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.
Nature structural & molecular biology 2010;17(8):939-47.
2010: Alessandro Vezzoli; Nicolas Bonadies; Mark D Allen; Stefan M V Freund; Clara M Santiveri; Brynn T Kvinlaug; Brian J P Huntly; Berthold Göttgens; Mark Bycroft
Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.
Nature structural & molecular biology 2010;17(5):617-9.
2009: Kian Hoe Khoo; Andreas C Joerger; Stefan M V Freund; Alan Fersht
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.
Protein engineering, design & selection : PEDS 2009;22(7):421-30.
2009: Katja Knauth; Edward Cartwright; Stefan M V Freund; Mark Bycroft; Alexander Buchberger
VHL mutations linked to type 2C von Hippel-Lindau disease cause extensive structural perturbations in pVHL.
The Journal of biological chemistry 2009;284(16):10514-22.
2009: Sarah Burge; Daniel P Teufel; Fiona M Townsley; Stefan M V Freund; Mark Bycroft; Alan Fersht
Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3142-7.
2009: Bernhard C Lechtenberg; Mark D Allen; Trevor J Rutherford; Stefan M V Freund; Mark Bycroft
Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2.
Protein science : a publication of the Protein Society 2009;18(3):657-61.
2008: Stefan M V Freund; Christopher M Johnson; Agnès M Jaulent; Neil Ferguson
Moving towards high-resolution descriptions of the molecular interactions and structural rearrangements of the human hepatitis B core protein.
Journal of molecular biology 2008;384(5):1301-13.
2008: Clara M Santiveri; Bernhard C Lechtenberg; Mark D Allen; Aruna Sathyamurthy; Agnès M Jaulent; Stefan M V Freund; Mark Bycroft
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.
Journal of molecular biology 2008;382(5):1107-12.
2007: Begona Sot; Stefan M V Freund; Alan Fersht
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.
The Journal of biological chemistry 2007;282(40):29193-200.
2007: Mark D Allen; Tomasz L Religa; Stefan M V Freund; Mark Bycroft
Solution structure of the BRK domains from CHD7.
Journal of molecular biology 2007;371(5):1135-40.
2007: Henning Tidow; Roberto Melero; Efstratios Mylonas; Stefan M V Freund; J Günter Grossmann; José María Carazo; Dmitri I Svergun; Mikel Valle; Alan Fersht
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12324-9.
2007: Daniel P Teufel; Stefan M V Freund; Mark Bycroft; Alan Fersht
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(17):7009-14.
2006: Viknesh Sivanathan; Mark D Allen; Charissa de Bekker; Rachel Baker; Lidia K Arciszewska; Stefan M V Freund; Mark Bycroft; Jan Löwe; David J Sherratt
The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS.
Nature structural & molecular biology 2006;13(11):965-72.
2006: Henning Tidow; Dmitry B Veprintsev; Stefan M V Freund; Alan Fersht
Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).
The Journal of biological chemistry 2006;281(43):32526-33.
2006: Mark D Allen; Charles G Grummitt; Christine Hilcenko; Sandra Young Min; Louise M Tonkin; Christopher M Johnson; Stefan M V Freund; Mark Bycroft; Alan J Warren
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase.
The EMBO journal 2006;25(19):4503-12.
2006: José Manuel Pérez Cañadillas; Henning Tidow; Stefan M V Freund; Trevor J Rutherford; Hwee Ching Ang; Alan Fersht
Solution structure of p53 core domain: structural basis for its instability.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2109-14.
2006: Dmitry B Veprintsev; Stefan M V Freund; Antonina Andreeva; Stacey E Rutledge; Henning Tidow; José Manuel Pérez Cañadillas; Caroline M Blair; Alan Fersht
Core domain interactions in full-length p53 in solution.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2115-9.
2006: Grace W Yu; Stefan Rudiger; Dmitry B Veprintsev; Stefan M V Freund; M Rosario Fernandez-Fernandez; Alan Fersht
The central region of HDM2 provides a second binding site for p53.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1227-32.
2005: Tomasz L Religa; J S Markson; Ugo Mayor; Stefan M V Freund; Alan Fersht
Solution structure of a protein denatured state and folding intermediate.
Nature 2005;437(7061):1053-6.
2005: Markus A Seeliger; Martin Spichty; Sadie E Kelly; Mark Bycroft; Stefan M V Freund; Martin Karplus; Laura S Itzhaki
Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.
The Journal of biological chemistry 2005;280(34):30448-59.
2005: Caroline M S Ekblad; Gayatri B Chavali; Balaku P Basu; Stefan M V Freund; Dmitry B Veprintsev; Luke Hughes-Davies; Tony Kouzarides; Aidan J Doherty; Laura S Itzhaki
Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
EMBO reports 2005;6(7):675-80.
2005: Assaf Friedler; Dmitry B Veprintsev; Stefan M V Freund; Karoly I von Glos; Alan Fersht
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation.
Structure (London, England : 1993) 2005;13(4):629-36.
2004: Richard L Weinberg; Stefan M V Freund; Dmitry B Veprintsev; Mark Bycroft; Alan Fersht
Regulation of DNA binding of p53 by its C-terminal domain.
Journal of molecular biology 2004;342(3):801-11.
2004: Robert B Best; Trevor J Rutherford; Stefan M V Freund; Jane Clarke
Hydrophobic core fluidity of homologous protein domains: relation of side-chain dynamics to core composition and packing.
Biochemistry 2004;43(5):1145-55.
2004: Oliver Schon; Assaf Friedler; Stefan M V Freund; Alan Fersht
Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes.
Journal of molecular biology 2004;336(1):197-202.
2004: Assaf Friedler; Brian S DeDecker; Stefan M V Freund; Caroline Blair; Stefan Rüdiger; Alan Fersht
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".
Journal of molecular biology 2004;336(1):187-96.
2003: Ugo Mayor; J Günter Grossmann; Nicholas W Foster; Stefan M V Freund; Alan Fersht
The denatured state of Engrailed Homeodomain under denaturing and native conditions.
Journal of molecular biology 2003;333(5):977-91.
2003: Elliott J Stollar; Ugo Mayor; Simon C Lovell; Luca Federici; Stefan M V Freund; Alan Fersht; Ben F Luisi
Crystal structures of engrailed homeodomain mutants: implications for stability and dynamics.
The Journal of biological chemistry 2003;278(44):43699-708.
2003: Ugo Mayor; Nicholas R Guydosh; Christopher M Johnson; J Günter Grossmann; Satoshi Sato; Gouri S Jas; Stefan M V Freund; Darwin O V Alonso; Valerie Daggett; Alan Fersht
The complete folding pathway of a protein from nanoseconds to microseconds.
Nature 2003;421(6925):863-7.
2002: Oliver Schon; Assaf Friedler; Mark Bycroft; Stefan M V Freund; Alan Fersht
Molecular mechanism of the interaction between MDM2 and p53.
Journal of molecular biology 2002;323(3):491-501.
2002: Stefan Rudiger; Stefan M V Freund; Dmitry B Veprintsev; Alan Fersht
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11085-90.
2002: Lars O Emrén; Assaf Friedler; Stefan M V Freund; Stefan Rudiger; Alan Fersht
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10305-9.
2002: Caroline M S Ekblad; Hannah R Wilkinson; Joost Schymkowitz; Frederic Rousseau; Stefan M V Freund; Laura S Itzhaki
Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.
Journal of molecular biology 2002;320(3):431-42.
2002: Thomas M Rippin; Stefan M V Freund; Dmitry B Veprintsev; Alan Fersht
Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding.
Journal of molecular biology 2002;319(2):351-8.
2002: Thomas M Rippin; Vladimir Bykov; Stefan M V Freund; Galina Selivanova; Klas G Wiman; Alan Fersht
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.
Oncogene 2002;21(14):2119-29.
2002: Assaf Friedler; Lars O Emrén; Dmitry B Veprintsev; Stefan M V Freund; Thomas M Rippin; Penka V Nikolova; Mark R Proctor; Stefan Rüdiger; Alan Fersht
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):937-42.
2001: SF Poget; Stefan M V Freund; Mark J Howard; Mark Bycroft
The ligand-binding loops in the tunicate C-type lectin TC14 are rigid.
Biochemistry 2001;40(37):10966-72.
2001: Steven L Kazmirski; Kam-Bo Wong; Stefan M V Freund; Y J Tan; Alan Fersht; Valerie Daggett
Protein folding from a highly disordered denatured state: the folding pathway of chymotrypsin inhibitor 2 at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4349-54.
2000: G B Legge; SF Poget; Mark R Proctor; Stefan M V Freund; Mark Bycroft
Letter to the editor: 1H, 13C and 15N NMR assignments of the C-type lectin TC14.
Journal of biomolecular NMR 2000;18(3):283-4.
2000: Alexander Buchberger; Mark J Howard; Stefan M V Freund; M Proctor; P J Butler; Alan Fersht; Mark Bycroft
Biophysical characterization of elongin C from Saccharomyces cerevisiae.
Biochemistry 2000;39(36):11137-46.
2000: Kam-Bo Wong; J Clarke; CJ Bond; J L Neira; Stefan M V Freund; Alan Fersht; Valerie Daggett
Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding.
Journal of molecular biology 2000;296(5):1257-82.
2000: A Ramos; stefan gruenert; Jan Adams; DR Micklem; Mark R Proctor; Stefan M V Freund; Mark Bycroft; Daniel St Johnston; Gabriele Varani
RNA recognition by a Staufen double-stranded RNA-binding domain.
The EMBO journal 2000;19(5):997-1009.
1999: N Kobayashi; Stefan M V Freund; J Chatellier; R Zahn; Alan Fersht
NMR analysis of the binding of a rhodanese peptide to a minichaperone in solution.
Journal of molecular biology 1999;292(1):181-90.
1999: Kam-Bo Wong; Brian S DeDecker; Stefan M V Freund; Mark R Proctor; Mark Bycroft; Alan Fersht
Hot-spot mutants of p53 core domain evince characteristic local structural changes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8438-42.
1998: S Fong; Mark Bycroft; J Clarke; Stefan M V Freund
Characterisation of urea-denatured states of an immunoglobulin superfamily domain by heteronuclear NMR.
Journal of molecular biology 1998;278(2):417-29.
1998: T R Killick; Stefan M V Freund; Alan Fersht
Real-time NMR studies on folding of mutants of barnase and chymotrypsin inhibitor 2.
FEBS letters 1998;423(1):110-2.
1997: Kam-Bo Wong; Alan Fersht; Stefan M V Freund
NMR 15N relaxation and structural studies reveal slow conformational exchange in barstar C40/82A.
Journal of molecular biology 1997;268(2):494-511.
1997: Mark Bycroft; Tim Hubbard; M Proctor; Stefan M V Freund; Alexey G Murzin
The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold.
Cell 1997;88(2):235-42.
1996: S Fong; Stefan J Hamill; Mark R Proctor; Stefan M V Freund; G M Benian; C Chothia; Mark Bycroft; Jane Clarke
Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.
Journal of molecular biology 1996;264(3):624-39.
1996: Stefan M V Freund; Kam-Bo Wong; Alan Fersht
Initiation sites of protein folding by NMR analysis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10600-3.
1996: Kam-Bo Wong; Stefan M V Freund; Alan Fersht
Cold denaturation of barstar: 1H, 15N and 13C NMR assignment and characterisation of residual structure.
Journal of molecular biology 1996;259(4):805-18.
1995: Vickery Arcus; S Vuilleumier; Stefan M V Freund; Mark Bycroft; Alan Fersht
A comparison of the pH, urea, and temperature-denatured states of barnase by heteronuclear NMR: implications for the initiation of protein folding.
Journal of molecular biology 1995;254(2):305-21.
1995: Mark Bycroft; Mark R Proctor; Stefan M V Freund; Daniel St Johnston
Assignment of the backbone 1H,15N,13C NMR resonances and secondary structure of a double-stranded RNA binding domain from the Drosophila protein staufen.
FEBS letters 1995;362(3):333-6.
1994: Vickery Arcus; S Vuilleumier; Stefan M V Freund; Mark Bycroft; Alan Fersht
Toward solving the folding pathway of barnase: the complete backbone 13C, 15N, and 1H NMR assignments of its pH-denatured state.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9412-6.
1994: M J Lubienski; Mark Bycroft; Stefan M V Freund; Alan Fersht
Three-dimensional solution structure and 13C assignments of barstar using nuclear magnetic resonance spectroscopy.
Biochemistry 1994;33(30):8866-77.