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Arnold Fridland
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Chemicals & Drugs
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Network (preview)
16
Robbins, Brian
12
Srinivas, Ranga
11
Johns, David
8
Mitsuya, Hiroaki
4
Ray, Adrian
4
Rodman, John
4
Flynn, Patricia
3
Connelly, MC
3
Vela, Jennifer
2
Bardeguez, Arlene
2
Grassi, Jacques
2
Perno, Carlo Federico
2
Marquez, Victor
1
Mirochnick, Mark
1
Mofenson, Lynne
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Geonetwork of Arnold Fridland (preview)
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All Publications
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2008: Reiser Hans; Wang Jianying; Chong Lee; Watkins William J; Ray Adrian S; Shibata Riri; Birkus Gabriel; Cihlar Tomas; Wu Sylvia; Li Bei; Liu Xiaohong; Henne Ilana N; Wolfgang Grushenka H I; Desai Manoj; Rhodes Gerald R; Fridland Arnold; Lee William A; Plunkett William; Vail David; Thamm Douglas H; Jeraj Robert; Tumas Daniel B
GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2824-32.
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2007: Mirochnick M; Rodman J H; Robbins B L; Fridland A; Gandía J; Hitti J; Bardeguez A; Rathore M H; Gonzalez Garcia A; Cababasay M; Samson P; Mofenson L; Bryson Y J; Dorenbaum A
Pharmacokinetics of oral zidovudine administered during labour: a preliminary study.
HIV medicine 2007;8(7):451-6.
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2007: Vela Jennifer E; Olson Loren Y; Huang Alan; Fridland Arnold; Ray Adrian S
Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2'-deoxyadenosine triphosphate by ion-pairing LC/MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;848(2):335-43.
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2005: Ray Adrian S; Myrick Florence; Vela Jennifer E; Olson Loren Y; Eisenberg Eugene J; Borroto-Esodo Katyna; Miller Michael D; Fridland Arnold
Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine.
Antiviral therapy 2005;10(3):451-7.
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2004: Ray Adrian S; Vela Jennifer E; Olson Loren; Fridland Arnold
Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells.
Biochemical pharmacology 2004;68(9):1825-31.
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2004: Ray Adrian S; Olson Loren; Fridland Arnold
Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir.
Antimicrobial agents and chemotherapy 2004;48(4):1089-95.
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2003: Robbins Brian L; Wilcox Carrie K; Fridland Arnold; Rodman John H
Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells.
Pharmacotherapy 2003;23(6):695-701.
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2003: Tran Thu T; Robbins Brian L; Pinkerton Frank H; Ferrua Bernard; Grassi Jacques; Fridland Arnold
A new sensitive cartridge-RIA method for determination of stavudine (D4T) triphosphate in human cells in vivo.
Antiviral research 2003;58(2):125-9.
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2000: Fridland A; Connelly M C; Robbins B L
Cellular factors for resistance against antiretroviral agents.
Antiviral therapy 2000;5(3):181-5.
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2000: Hughes W T; Shenep J L; Rodman J H; Fridland A; Willoughby R; Blanchard S; Purdue L; Coakley D F; Cundy K C; Culnane M; Zimmer B; Burchett S; Read J S
Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group.
Antimicrobial agents and chemotherapy 2000;44(4):1041-6.
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2000: Robbins B L; Greenhaw J; Fridland A
Cellular phosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key intermediate in the activation of the antiviral agent DDI, in human peripheral blood mononuclear cells.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):405-13.
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1999: Rodman J H; Flynn P M; Robbins B; Jimenez E; Bardeguez A D; Rodriguez J F; Blanchard S; Fridland A
Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants.
The Journal of infectious diseases 1999;180(6):1844-50.
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1999: Schuetz J D; Connelly M C; Sun D; Paibir S G; Flynn P M; Srinivas R V; Kumar A; Fridland A
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.
Nature medicine 1999;5(9):1048-51.
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1998: Srinivas R V; Middlemas D; Flynn P; Fridland A
Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters.
Antimicrobial agents and chemotherapy 1998;42(12):3157-62.
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1998: Robbins B L; Tran T T; Pinkerton F H; Akeb F; Guedj R; Grassi J; Lancaster D; Fridland A
Development of a new cartridge radioimmunoassay for determination of intracellular levels of lamivudine triphosphate in the peripheral blood mononuclear cells of human immunodeficiency virus-infected patients.
Antimicrobial agents and chemotherapy 1998;42(10):2656-60.
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1998: Srinivas R V; Fridland A
Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains.
Antimicrobial agents and chemotherapy 1998;42(6):1484-7.
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1998: Robbins B L; Srinivas R V; Kim C; Bischofberger N; Fridland A
Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.
Antimicrobial agents and chemotherapy 1998;42(3):612-7.
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1997: Pisarev V M; Lee S H; Connelly M C; Fridland A
Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.
Molecular pharmacology 1997;52(1):63-8.
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1997: Srinivas R V; Connely M; Fridland A
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes.
Antiviral research 1997;35(1):23-7.
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1997: Tanaka M; Srinivas R V; Ueno T; Kavlick M F; Hui F K; Fridland A; Driscoll J S; Mitsuya H
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine.
Antimicrobial agents and chemotherapy 1997;41(6):1313-8.
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1996: Robbins B L; Waibel B H; Fridland A
Quantitation of intracellular zidovudine phosphates by use of combined cartridge-radioimmunoassay methodology.
Antimicrobial agents and chemotherapy 1996;40(11):2651-4.
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1996: Rodman J H; Robbins B; Flynn P M; Fridland A
A systemic and cellular model for zidovudine plasma concentrations and intracellular phosphorylation in patients.
The Journal of infectious diseases 1996;174(3):490-9.
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1995: Robbins B L; Greenhaw J; Connelly M C; Fridland A
Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells.
Antimicrobial agents and chemotherapy 1995;39(10):2304-8.
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1995: Aduma P; Connelly M C; Srinivas R V; Fridland A
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates.
Molecular pharmacology 1995;47(4):816-22.
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1995: Robbins B L; Connelly M C; Marshall D R; Srinivas R V; Fridland A
A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent.
Molecular pharmacology 1995;47(2):391-7.
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1994: Gong Y F; Marshall D R; Srinivas R V; Fridland A
Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates.
Antimicrobial agents and chemotherapy 1994;38(7):1683-7.
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1994: Robbins B L; Rodman J; McDonald C; Srinivas R V; Flynn P M; Fridland A
Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells.
Antimicrobial agents and chemotherapy 1994;38(1):115-21.
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1993: Srinivas R V; Robbins B L; Connelly M C; Gong Y F; Bischofberger N; Fridland A
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.
Antimicrobial agents and chemotherapy 1993;37(10):2247-50.
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1993: Connelly M C; Robbins B L; Fridland A
Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cells.
Biochemical pharmacology 1993;46(6):1053-7.
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1993: Gong Y F; Srinivas R V; Fridland A
5-Amino-4-imidazolecarboxamide riboside potentiates the metabolism and anti-human immunodeficiency virus activity of 2',3'-dideoxyinosine.
Molecular pharmacology 1993;44(1):30-6.
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1993: Ahluwalia G; Cooney D A; Hartman N R; Mitsuya H; Yarchoan R; Fridland A; Broder S; Johns D G
Anomalous accumulation and decay of 2',3'-dideoxyadenosine-5'-triphosphate in human T-cell cultures exposed to the anti-HIV drug 2',3'-dideoxyinosine.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(2):369-76.
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1992: Bondoc L L; Ahluwalia G; Cooney D A; Hartman N R; Johns D G; Fridland A
Metabolic pathways for the activation of the antiviral agent 2',3'-dideoxyguanosine in human lymphoid cells.
Molecular pharmacology 1992;42(3):525-30.
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1991: Hartman N R; Ahluwalia G S; Cooney D A; Mitsuya H; Kageyama S; Fridland A; Broder S; Johns D G
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.
Molecular pharmacology 1991;40(1):118-24.
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1991: Bondoc L L; Robbins B L; Ahluwalia G S; Mitsuya H; Johns D G; Fridland A
Modulation of metabolism and anti-HIV-1 activity of purine 2',3'-dideoxynucleosides by IMP dehydrogenase inhibitors.
Advances in experimental medicine and biology 1991;309A():49-53.
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1990: Bondoc L L; Shannon W M; Secrist J A; Vince R; Fridland A
Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells.
Biochemistry 1990;29(42):9839-43.
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1990: Ahluwalia G; Cooney D A; Bondoc L L; Currens M J; Ford H; Johns D G; Mitsuya H; Fridland A
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the antiviral nucleoside 2' ,3'-dideoxyguanosine.
Biochemical and biophysical research communications 1990;171(3):1297-303.
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1990: Fridland A; Connelly M C; Ashmun R
Relationship of deoxynucleotide changes to inhibition of DNA synthesis induced by the antiretroviral agent 3'-azido-3'-deoxythymidine and release of its monophosphate by human lymphoid cells (CCRF-CEM).
Molecular pharmacology 1990;37(5):665-70.
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1990: Masood R; Ahluwalia G S; Cooney D A; Fridland A; Marquez V E; Driscoll J S; Hao Z; Mitsuya H; Perno C F; Broder S
2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosine.
Molecular pharmacology 1990;37(4):590-6.
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1990: Fridland A; Johnson M A; Cooney D A; Ahluwalia G; Marquez V E; Driscoll J S; Johns D G
Metabolism in human leukocytes of anti-HIV dideoxypurine nucleosides.
Annals of the New York Academy of Sciences 1990;616():205-16.
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1989: Johnson M A; Fridland A
Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.
Molecular pharmacology 1989;36(2):291-5.
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1989: Sarup J C; Johnson M A; Verhoef V; Fridland A
Regulation of purine deoxynucleoside phosphorylation by deoxycytidine kinase from human leukemic blast cells.
Biochemical pharmacology 1989;38(16):2601-7.
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1988: Johnson M A; Ahluwalia G; Connelly M C; Cooney D A; Broder S; Johns D G; Fridland A
Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.
The Journal of biological chemistry 1988;263(30):15354-7.
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1988: Hao Z; Cooney D A; Hartman N R; Perno C F; Fridland A; DeVico A L; Sarngadharan M G; Broder S; Johns D G
Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro.
Molecular pharmacology 1988;34(4):431-5.
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1987: Ahluwalia G; Cooney D A; Mitsuya H; Fridland A; Flora K P; Hao Z; Dalal M; Broder S; Johns D G
Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity.
Biochemical pharmacology 1987;36(22):3797-800.
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1987: Johnson M A; Johns D G; Fridland A
2',3'-Dideoxynucleoside phosphorylation by deoxycytidine kinase from normal human thymus extracts: activation of potential drugs for AIDS therapy.
Biochemical and biophysical research communications 1987;148(3):1252-8.
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1987: Cooney D A; Ahluwalia G; Mitsuya H; Fridland A; Johnson M; Hao Z; Dalal M; Balzarini J; Broder S; Johns D G
Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity.
Biochemical pharmacology 1987;36(11):1765-8.
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1987: Fridland A; Verhoef V
Mechanism for ara-CTP catabolism in human leukemic cells and effect of deaminase inhibitors on this process.
Seminars in oncology 1987;14(2 Suppl 1):262-8.
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1987: Sarup J C; Fridland A
Identification of purine deoxyribonucleoside kinases from human leukemia cells: substrate activation by purine and pyrimidine deoxyribonucleosides.
Biochemistry 1987;26(2):590-7.
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1986: Verhoef V; Ashmun R; Fridland A
Rhodamine 123 and flow cytometry to monitor the cytotoxic actions of nucleoside analogues in nondividing human lymphocytes.
Anticancer research 1986;6(5):1117-21.
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1986: Fridland A; Connelly M C; Robbins T J
Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase.
Cancer research 1986;46(2):532-7.
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1985: Fridland A; Verhoef V
Metabolism and selectivity of arabinonucleoside in human lymphoid cells.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1985;179(4):456-62.
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1985: Verhoef V; Fridland A
Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts.
Cancer research 1985;45(8):3646-50.
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1983: Verhoef V; Germain G; Fridland A
Adenosine phosphorylase activity in mycoplasma-free growth media for mammalian cells.
Experimental cell research 1983;149(1):37-44.
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1983: Chwang T L; Fridland A; Verhoef V
Novel derivatives of 9-beta-D-arabinofuranosylpurines that are cytotoxic to variants of human leukemia lymphoblast cells resistant to both 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosyladenine.
Biochemical pharmacology 1983;32(17):2943-6.
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1983: Chwang T L; Fridland A; Avery T L
2'-O-nitro-1-beta-D-arabinofuranosylcytosine. A new derivative of 1-beta-D-arabinofuranosylcytosine that resists enzymatic deamination and has antileukemic activity.
Journal of medicinal chemistry 1983;26(2):280-3.
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1981: Verhoef V; Sarup J; Fridland A
Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases.
Cancer research 1981;41(11 Pt 1):4478-83.
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