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Jane Fridlyand

Research Profile

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Jill M Spoerke; Sankar Mohan; Carol O'Brien; Ajay Pandita; Leanne Ross; Deepak Sampath; David S Shames; Lukas C Amler; Rainer K Brachmann; Jane Fridlyand; Lori S Friedman; Garret M Hampton; Peter M Haverty; Ling Huw; Hartmut Koeppen; Mark R Lackner
Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models.
Timothy R Wilson; Yibing Yan; Jeff Sosman; Daniel P Sutherlin; Yulei Wang; Luciana Burton; Emily Chan; Jane Fridlyand; Hartmut Koeppen; Jiang Li; Eva Lin; Mark Merchant; John Moffat; Richard Neve; Jing Peng; Elicia Penuel; Antoni Ribas; Jeff Settleman
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Jane Fridlyand; Lee D Kaiser; Gwen Fyfe
Analysis of tumor burden versus progression-free survival for Phase II decision making.

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All Publications

2012: Jill M Spoerke; Sankar Mohan; Carol O'Brien; Ajay Pandita; Leanne Ross; Deepak Sampath; David S Shames; Lukas C Amler; Rainer K Brachmann; Jane Fridlyand; Lori S Friedman; Garret M Hampton; Peter M Haverty; Ling Huw; Hartmut Koeppen; Mark R Lackner
Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(24):6771-83.
2012: Timothy R Wilson; Yibing Yan; Jeff Sosman; Daniel P Sutherlin; Yulei Wang; Luciana Burton; Emily Chan; Jane Fridlyand; Hartmut Koeppen; Jiang Li; Eva Lin; Mark Merchant; John Moffat; Richard Neve; Jing Peng; Elicia Penuel; Antoni Ribas; Jeff Settleman
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Nature 2012;487(7408):505-9.
2011: Jane Fridlyand; Lee D Kaiser; Gwen Fyfe
Analysis of tumor burden versus progression-free survival for Phase II decision making.
Contemporary clinical trials 2011;32(3):446-52.
2010: Bruno M Costa; Justin S Smith; Ying Chen; Justin Chen; Heidi S Phillips; Kenneth Aldape; Giuseppe Zardo; Janice M Nigro; C David James; Jane Fridlyand; Rui M Reis; Joseph F Costello
Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma.
Cancer research 2010;70(2):453-62.
2010: Erich P Huang; Jane Fridlyand; Nicholas Lewin-Koh; Peng Yue; Xiaoyan Shi; David Dornan; Bart Burington
Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data.
BMC cancer 2010;10():586.
2009: Bryan T. J. Hennessy; Ana M Gonzalez-Angulo; Katherine Stemke-Hale; Michael Z Gilcrease; Savitri Krishnamurthy; Ju-Seog Lee; Jane Fridlyand; Aysegul Sahin; Roshan Agarwal; Corwin Joy; Wenbin Liu; David N Stivers; Keith A Baggerly; Mark Carey; Ana Lluch; Carlos Monteagudo; Xiaping He; Victor Weigman; Cheng Fan; Juan Palazzo; Gabriel N Hortobagyi; Laura K Nolden; Nicholas J Wang; Vicente Valero; Joe Gray; Charles M Perou; Gordon B Mills
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Cancer research 2009;69(10):4116-24.
2009: S S Kwek; R Roy; H Zhou; Joan CLIMENT; J A Martinez-Climent; Jane Fridlyand; Donna G Albertson
Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis.
Oncogene 2009;28(17):1892-903.
2008: Amaya Viros; Jane Fridlyand; Jürgen Bauer; Konstantin Lasithiotakis; Claus Garbe; Daniel Pinkel; Boris C Bastian
Improving melanoma classification by integrating genetic and morphologic features.
PLoS medicine 2008;5(6):e120.
2008: Peter M Haverty; Jane Fridlyand; Li Li; Gad Getz; Rameen Beroukhim; Scott Lohr; Thomas D Wu; Guy Cavet; Zemin Zhang; Chant John
High-resolution genomic and expression analyses of copy number alterations in breast tumors.
Genes, chromosomes & cancer 2008;47(6):530-42.
2008: Kristin N Byrd; Bing Huey; Ritu Roydasgupta; Jane Fridlyand; Antoine M Snijders; Donna G Albertson
FBXW7 and DNA copy number instability.
Breast cancer research and treatment 2008;109(1):47-54.
2008: Susie A Lee; Coral Ho; Ritu Roy; Cynthia Kosinski; Mohini A Patil; Aaron D Tward; Jane Fridlyand; Xin Chen
Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer.
Hepatology (Baltimore, Md.) 2008;47(4):1200-10.
2008: Nobumoto Tomioka; S Oba; Miki Ohira; A Misra; Jane Fridlyand; S Ishii; Yohko Nakamura; Eriko Isogai; Takahiro Hirata; Y Yoshida; Satoru Todo; Yasuhiko Kaneko; D G Albertson; D Pinkel; Burt Feuerstein; Akira Nakagawara
Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature.
Oncogene 2008;27(4):441-9.
2008: Sushmita Roy; S Andrew Josephson; Jane Fridlyand; Jon Karch; Cigall Kadoch; Juliana Karrim; Lloyd Damon; Patrick Treseler; Sandeep Kunwar; Marc Shuman; Ted Jones; Christopher H Becker; Howard Schulman; James L Rubenstein
Protein biomarker identification in the CSF of patients with CNS lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(1):96-105.
2008: Antoine M Snijders; Mario A Hermsen; Joshua Baughman; Tineke E Buffart; Bing Huey; Pavla Gajduskova; Ritu Roydasgupta; Taku Tokuyasu; Gerrit A Meijer; Jane Fridlyand; Donna G Albertson
Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability.
Genes, chromosomes & cancer 2008;47(1):71-83.
2007: Adam Hittelman; Shivaranjani Sridharan; Ritu Roy; Jane Fridlyand; Massimo Loda; Colin Collins; Pamela L Paris
Evaluation of whole genome amplification protocols for array and oligonucleotide CGH.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2007;16(4):198-206.
2007: Yinghui Guan; Wen-Lin Kuo; Jackie L Stilwell; Hirokuni Takano; Anna Lapuk; Jane Fridlyand; Jian-Hua Mao; Mamie Yu; Melinda A Miller; Jennifer L Santos; Steve Kalloger; Joseph W Carlson; David Ginzinger; Susan E Celniker; Gordon B Mills; David Huntsman; Joe Gray
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5745-55.
2007: James L Rubenstein; Jane Fridlyand; Lauren E Abrey; Arthur Shen; Jon Karch; Endi Wang; Samar Issa; Lloyd Damon; Michael Prados; Michael McDermott; Joan O'Brien; Christopher Haqq; Marc Shuman
Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(11):1350-6.
2007: Joan CLIMENT; Peter Dimitrow; Jane Fridlyand; Jose Palacios; Reiner Siebert; Donna G Albertson; Joe Gray; Daniel Pinkel; Ana Lluch; Jose A Martinez-Climent
Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer.
Cancer research 2007;67(2):818-26.
2007: Christina Yau; Vita Fedele; Ritu Roydasgupta; Jane Fridlyand; Alan Hubbard; Joe Gray; Karen L Chew; Shanaz H Dairkee; Dan H Moore; Francesco Schittulli; Stefania Tommasi; angelo paradiso; Donna G Albertson; Christopher C Benz
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers.
Breast cancer research : BCR 2007;9(5):R59.
2007: Pavla Gajduskova; Antoine M Snijders; Serena Kwek; Ritu Roydasgupta; Jane Fridlyand; Taku Tokuyasu; Daniel Pinkel; Donna G Albertson
Genome position and gene amplification.
Genome biology 2007;8(6):R120.
2007: Christoph Thorns; Boris C Bastian; Daniel Pinkel; Ritu Roydasgupta; Jane Fridlyand; Hartmut Merz; Manuela Krokowski; Heinz-Wolfram Bernd; Alfred C Feller
Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach.
Genes, chromosomes & cancer 2007;46(1):37-44.
2006: Koei Chin; Sandy Devries; Jane Fridlyand; Paul Spellman; Ritu Roydasgupta; Wen-Lin Kuo; Anna Lapuk; Richard M Neve; Zuwei Qian; Tom Ryder; Fanqing Chen; Heidi Feiler; Taku Tokuyasu; Christopher Kingsley; Shanaz H Dairkee; Zhenhang Meng; Karen L Chew; Daniel Pinkel; Ajay Jain; Britt-Marie Ljung; Laura Esserman; Donna G Albertson; Frederic M Waldman; Joe Gray
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
Cancer cell 2006;10(6):529-41.
2006: Richard M Neve; Koei Chin; Jane Fridlyand; Jennifer Yeh; Frederick L Baehner; Tea Fevr; Laura Clark; Nora Bayani; Jean-Philippe Coppe; Frances Tong; Terence P Speed; Paul Spellman; Sandy Devries; Anna Lapuk; Nick J Wang; Wen-Lin Kuo; Jackie L Stilwell; Daniel Pinkel; Donna G Albertson; Frederic M Waldman; Frank McCormick; Robert B Dickson; Michael D Johnson; Marc Lippman; Stephen Ethier; Adi F Gazdar; Joe Gray
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer cell 2006;10(6):515-27.
2006: Karolin Trautmann; Jonathan P Terdiman; Amy J French; Ritu Roydasgupta; Nancy Sein; Sanjay Kakar; Jane Fridlyand; Antoine M Snijders; Donna G Albertson; Stephen N Thibodeau; Frederic M Waldman
Chromosomal instability in microsatellite-unstable and stable colon cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6379-85.
2006: Paul A Reynolds; Mahvash Sigaroudinia; Giuseppe Zardo; Matthew B Wilson; Geoffrey M Benton; Caroline J Miller; Chibo Hong; Jane Fridlyand; Joseph F Costello; Thea D Tlsty
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
The Journal of biological chemistry 2006;281(34):24790-802.
2006: James L Rubenstein; Jane Fridlyand; Arthur Shen; Kenneth Aldape; David Ginzinger; Tracy Batchelor; Patrick Treseler; Mitchel Berger; Michael McDermott; Michael Prados; Jon Karch; Craig Y Okada; William Hyun; Seema Parikh; Christopher Haqq; Marc Shuman
Gene expression and angiotropism in primary CNS lymphoma.
Blood 2006;107(9):3716-23.
2006: Kimberly J Bussey; Koei Chin; Samir Lababidi; Mark Reimers; William C Reinhold; Wen-Lin Kuo; Fuad G Gwadry; Hosein Kouros-Mehr; Jane Fridlyand; Ajay Jain; Colin Collins; Satoshi Nishizuka; Giovanni Tonon; Anna V Roschke; Kristen S Gehlhaus; Ilan Kirsch; Dominic A Scudiero; Joe Gray; John N Weinstein
Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel.
Molecular cancer therapeutics 2006;5(4):853-67.
2006: Donna G Albertson; Antoine M Snijders; Jane Fridlyand; Richard Jordan; Daniel Pinkel; Brian L Schmidt
Genomic analysis of tumors by array comparative genomic hybridization: more is better.
Cancer research 2006;66(7):3955-6; author reply 3956.
2006: Ying Chen; Amanda E. Toland; Jane McLennan; Jane Fridlyand; Beth Crawford; Joseph F Costello; John L Ziegler
Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer.
Genetic testing 2006;10(4):281-4.
2006: Jane Fridlyand; Antoine M Snijders; Bauke Ylstra; Hua Li; Adam B Olshen; Richard Segraves; Shanaz H Dairkee; Taku Tokuyasu; Britt-Marie Ljung; Ajay N Jain; Jane McLennan; John Ziegler; Koei Chin; Sandy Devries; Heidi Feiler; Joe Gray; Frederic M Waldman; Daniel Pinkel; Donna G Albertson
Breast tumor copy number aberration phenotypes and genomic instability.
BMC cancer 2006;6():96.
2005: John A Curtin; Jane Fridlyand; Toshiro Kageshita; Hetal N Patel; Klaus J Busam; Heinz Kutzner; Kwang-Hyun Cho; Setsuya Aiba; Eva-B Bröcker; Philip E LeBoit; Daniel Pinkel; Boris C Bastian
Distinct sets of genetic alterations in melanoma.
The New England journal of medicine 2005;353(20):2135-47.
2005: Hanni Willenbrock; Jane Fridlyand
A comparison study: applying segmentation to array CGH data for downstream analyses.
Bioinformatics (Oxford, England) 2005;21(22):4084-91.
2005: Richard C Chao; Urszula Pyzel; Jane Fridlyand; Yien-Ming Kuo; Lewis Teel; Jennifer Haaga; Alexander D Borowsky; Andrew Horvai; Scott C Kogan; Jeannette Bonifas; Bing Huey; Tyler Jacks; Donna G Albertson; Kevin Shannon
Therapy-induced malignant neoplasms in Nf1 mutant mice.
Cancer cell 2005;8(4):337-48.
2005: Ekaterina Blaveri; Jeremy L Brewer; Ritu Roydasgupta; Jane Fridlyand; Sandy Devries; Theresa Koppie; Sunanda Pejavar; Kshama Mehta; Peter Carroll; Jeff Simko; Frederic M Waldman
Bladder cancer stage and outcome by array-based comparative genomic hybridization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):7012-22.
2005: Antoine M Snijders; Brian L Schmidt; Jane Fridlyand; Nusi Dekker; Daniel Pinkel; RICHARD JORDAN; Donna G Albertson
Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma.
Oncogene 2005;24(26):4232-42.
2005: Tsui-Ting Ching; Alika K Maunakea; Peter Jun; Chibo Hong; Giuseppe Zardo; Daniel Pinkel; Donna G Albertson; Jane Fridlyand; Jian-Hua Mao; Ksenya Shchors; William A Weiss; Joseph F Costello
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3.
Nature genetics 2005;37(6):645-51.
2005: Antoine M Snijders; Norma J Nowak; Bing Huey; Jane Fridlyand; Sindy Law; Jeffrey Conroy; Taku Tokuyasu; Kubilay Demir; Readman Chiu; Jian-Hua Mao; Ajay N Jain; Steven J M Jones; Allan Balmain; Daniel Pinkel; Donna G Albertson
Mapping segmental and sequence variations among laboratory mice using BAC array CGH.
Genome research 2005;15(2):302-11.
2004: Kentaro Nakao; Kshama R Mehta; Jane Fridlyand; Dan H Moore; Ajay N Jain; Amalia Lafuente; John W Wiencke; Jonathan P Terdiman; Frederic M Waldman
High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.
Carcinogenesis 2004;25(8):1345-57.
2004: Pamela L Paris; Armann Andaya; Jane Fridlyand; Ajay N Jain; Vivian Weinberg; David Kowbel; John H Brebner; Jeff Simko; J E Vivienne Watson; Stanislav Volik; Donna G Albertson; Daniel Pinkel; Janneke C Alers; Theo Van der Kwast; Kees J Vissers; Fritz H Schroder; Mark F Wildhagen; Phillip G Febbo; Arul M Chinnaiyan; Kenneth J Pienta; Peter R Carroll; Mark A Rubin; Colin Collins; Herman van Dekken
Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors.
Human molecular genetics 2004;13(13):1303-13.
2004: Janet L Maldonado; Luika Timmerman; Jane Fridlyand; Boris C Bastian
Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway.
The American journal of pathology 2004;164(5):1783-7.
2004: Jeffrey H Hager; J Graeme Hodgson; Jane Fridlyand; Sujatmi Hariono; Joe Gray; Douglas Hanahan
Oncogene expression and genetic background influence the frequency of DNA copy number abnormalities in mouse pancreatic islet cell carcinomas.
Cancer research 2004;64(7):2406-10.
2003: Janet L Maldonado; Jane Fridlyand; Hetal Patel; Ajay N Jain; Klaus J Busam; Toshiro Kageshita; Tomomichi Ono; Donna G Albertson; Daniel Pinkel; Boris C Bastian
Determinants of BRAF mutations in primary melanomas.
Journal of the National Cancer Institute 2003;95(24):1878-90.
2003: James Korkola; Sandy Devries; Jane Fridlyand; E Shelley Hwang; Anne L H Estep; Yunn-Yi Chen; Karen L Chew; Shanaz H Dairkee; Ronald M Jensen; Frederic M Waldman
Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis.
Cancer research 2003;63(21):7167-75.
2003: Christopher S Hackett; J Graeme Hodgson; Mark E Law; Jane Fridlyand; Kazutoyo Osoegawa; Pieter J de Jong; Norma J Nowak; Daniel Pinkel; Donna G Albertson; Ajay Jain; Robert Jenkins; Joe Gray; William A Weiss
Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.
Cancer research 2003;63(17):5266-73.
2003: Antoine M Snijders; Jane Fridlyand; Dorus A Mans; Richard Segraves; Ajay N Jain; Daniel Pinkel; Donna G Albertson
Shaping of tumor and drug-resistant genomes by instability and selection.
Oncogene 2003;22(28):4370-9.
2003: Antoine M Snijders; Marlies E Nowee; Jane Fridlyand; Jurgen M J Piek; Josephine C Dorsman; Ajay N Jain; Daniel Pinkel; Paulus van Diest; René H M Verheijen; Donna G Albertson
Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma.
Oncogene 2003;22(27):4281-6.
2003: Sandrine Dudoit; Jane Fridlyand
Bagging to improve the accuracy of a clustering procedure.
Bioinformatics (Oxford, England) 2003;19(9):1090-9.
2003: Joris Veltman; Jane Fridlyand; Sunanda Pejavar; Adam B Olshen; James Korkola; Sandy Devries; Peter Carroll; Wen-Lin Kuo; Daniel Pinkel; Donna Albertson; Carlos Cordon-Cardo; Ajay N Jain; Frederic M Waldman
Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.
Cancer research 2003;63(11):2872-80.
2003: Pamela L Paris; Donna G Albertson; Janneke C Alers; Armann Andaya; Peter Carroll; Jane Fridlyand; Ajay N Jain; Sherwin Kamkar; David Kowbel; Pieter-Jaap Krijtenburg; Daniel Pinkel; Fritz H Schröder; Kees J Vissers; Vivienne J E Watson; Mark F Wildhagen; Colin Collins; Herman van Dekken
High-resolution analysis of paraffin-embedded and formalin-fixed prostate tumors using comparative genomic hybridization to genomic microarrays.
The American journal of pathology 2003;162(3):763-70.
2002: R C Andrew Symons; Mark J Daly; Jane Fridlyand; Terence P Speed; Wendy D Cook; Steve Gerondakis; Alan W Harris; Simon J Foote
Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11299-304.
2002: Sandrine Dudoit; Jane Fridlyand
A prediction-based resampling method for estimating the number of clusters in a dataset.
Genome biology 2002;3(7):RESEARCH0036.