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Rafael Fridman

Research Profile

Chemicals & Drugs

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Mouse

Physiology

Enzyme Activation

Anatomy

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Hsueh-Liang Fu; Malika Kumarasiri; Kiran V Mahasenan; Shahriar Mobashery; anjum sohail; Dorota Tokmina-Roszyk; Rajeshwari R Valiathan; Benjamin D Wasinski; Maria Margarida Bernardo; Gregg B Fields; Rafael Fridman
Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases.
Hsueh-Liang Fu; Paul H. Huang; Malika Kumarasiri; Kiran V Mahasenan; Cosmin Mihai; Shahriar Mobashery; anjum sohail; Rajeshwari R Valiathan; Gunjan Agarwal; Richard Arkwright; Rafael Fridman
Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.
Rafael Fridman; Hynda K Kleinman; Irina Aranoutova; Gabriel Benton; R Daniel Bonfil
Increased initiation and growth of tumor cell lines, cancer stem cells and biopsy material in mice using basement membrane matrix protein (Cultrex or Matrigel) co-injection.

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2013: Hsueh-Liang Fu; Malika Kumarasiri; Kiran V Mahasenan; Shahriar Mobashery; anjum sohail; Dorota Tokmina-Roszyk; Rajeshwari R Valiathan; Benjamin D Wasinski; Maria Margarida Bernardo; Gregg B Fields; Rafael Fridman
Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases.
The Journal of biological chemistry 2013;288(17):12114-29.
2013: Hsueh-Liang Fu; Paul H. Huang; Malika Kumarasiri; Kiran V Mahasenan; Cosmin Mihai; Shahriar Mobashery; anjum sohail; Rajeshwari R Valiathan; Gunjan Agarwal; Richard Arkwright; Rafael Fridman
Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.
The Journal of biological chemistry 2013;288(11):7430-7.
2012: Rafael Fridman; Hynda K Kleinman; Irina Aranoutova; Gabriel Benton; R Daniel Bonfil
Increased initiation and growth of tumor cell lines, cancer stem cells and biopsy material in mice using basement membrane matrix protein (Cultrex or Matrigel) co-injection.
Nature protocols 2012;7(6):1138-44.
2012: Rajeshwari R Valiathan; Celina G Kleer; Birgit Leitinger; Marta Marco; Rafael Fridman
Discoidin domain receptor tyrosine kinases: new players in cancer progression.
Cancer metastasis reviews 2012;31(1-2):295-321.
2012: M Katie Conley-LaComb; Rafael Fridman; Wei Huang; Young Suk Jung; R Daniel Bonfil; Yong Q Chen; Michael L Cher; Abdo Najy; Dongping Shi; Shihua Wang; Hyeong-Reh Choi Kim
PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer.
The American journal of pathology 2012;180(3):1017-27.
2012: Young Suk Jung; Rosemarie Chirco; Rafael Fridman; Xu-Wen Liu; Richard B Warner; Hyeong-Reh Choi Kim
TIMP-1 induces an EMT-like phenotypic conversion in MDCK cells independent of its MMP-inhibitory domain.
PloS one 2012;7(6):e38773.
2012: Marta Toth; Anjum Sohail; Rafael Fridman
Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography.
Methods in molecular biology (Clifton, N.J.) 2012;878():121-35.
2011: anjum sohail; Huiren Zhao; Marta Marco; Scott Merriman; Shahriar Mobashery; Qicun Shi; Rafael Fridman
Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase.
The Journal of biological chemistry 2011;286(38):33178-89.
2011: Melissa Dobson; Rafael Fridman; Ludmila Kaplun; Stephanie Ma; Gopalakrishnan Ramakrishnan; Vitaly Balan; Guri Tzivion
Bimodal regulation of FoxO3 by AKT and 14-3-3.
Biochimica et biophysica acta 2011;1813(8):1453-64.
2011: Elisa Nuti; Francesca Casalini; Salvatore Santamaria; Pamela Gabelloni; Sara Bendinelli; Eleonora Da Pozzo; Barbara Costa; Luciana Marinelli; Valeria La Pietra; Ettore Novellino; M Margarida Bernardo; Rafael Fridman; Federico Da Settimo; Claudia Martini; Armando Rossello
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
European journal of medicinal chemistry 2011;46(7):2617-29.
2010: Essa Mayyas; Maria Margarida Bernardo; Lindsay Runyan; anjum sohail; Venkatesh Subba-Rao; MA Pantea; Rafael Fridman; Peter Manfred Hoffmann
Dissociation kinetics of an enzyme-inhibitor system using single-molecule force measurements.
Biomacromolecules 2010;11(12):3352-8.
2010: Seaho Kim; Wei Huang; Emilio P Mottillo; anjum sohail; Yoon-Ah Ham; M Katie Conley-Lacomb; Chong Jai Kim; Guri Tzivion; Hyeong-Reh Choi Kim; Shihua Wang; Yong Q Chen; Rafael Fridman
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
Biochimica et biophysica acta 2010;1803(11):1287-97.
2010: Carl Fortin; anjum sohail; Qing Sun; Patrick P McDonald; Rafael Fridman; Tamàs Fülöp
MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis.
International immunology 2010;22(8):637-49.
2010: Aaron L Sabbota; Hyeong-Reh Choi Kim; Xiaoning Zhe; Rafael Fridman; R Daniel Bonfil; Michael L Cher
Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration.
Cancer research 2010;70(13):5558-66.
2010: Rafael Fridman
Matrix metalloproteinases.
Biochimica et biophysica acta 2010;1803(1):1-2.
2009: Major Gooyit; Mijoon Lee; Dusan Hesek; Bill Boggess; Allen G Oliver; Rafael Fridman; Shahriar Mobashery; Mayland Chang
Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.
Chemical biology & drug design 2009;74(6):535-46.
2009: Christopher Forbes; Qicun Shi; Jed F Fisher; Mijoon Lee; Dusan Hesek; Leticia I Llarrull; Marta Toth; Michael Gossing; Rafael Fridman; Shahriar Mobashery
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
Chemical biology & drug design 2009;74(6):527-34.
2009: Mijoon Lee; giuseppe celenza; Bill Boggess; Jennifer Blase; Qicun Shi; Marta Toth; Maria Margarida Bernardo; William R Wolter; Mark A Suckow; Dusan Hesek; Bruce C Noll; Rafael Fridman; Shahriar Mobashery; Mayland Chang
A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.
Chemical biology & drug design 2009;73(2):189-202.
2008: Huiren Zhao; anjum sohail; Qing Sun; Qicun Shi; Seaho Kim; Shahriar Mobashery; Rafael Fridman
Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25).
The Journal of biological chemistry 2008;283(50):35023-32.
2008: Danmei Xu; Naoko Suenaga; Mariola J Edelmann; Rafael Fridman; Ruth J Muschel; Benedikt M Kessler
Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach.
Molecular & cellular proteomics : MCP 2008;7(11):2215-28.
2008: R Daniel Bonfil; Rafael Fridman; Shahriar Mobashery; Michael L Cher
Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis?
Current oncology (Toronto, Ont.) 2008;15(4):188-92.
2008: Jin-Ah Cho; Pamela Osenkowski; Huiren Zhao; Seaho Kim; Marta Toth; Kristina Cole; Amro Aboukameel; Allen Saliganan; Lucia Schuger; R Daniel Bonfil; Rafael Fridman
The inactive 44-kDa processed form of membrane type 1 matrix metalloproteinase (MT1-MMP) enhances proteolytic activity via regulation of endocytosis of active MT1-MMP.
The Journal of biological chemistry 2008;283(25):17391-405.
2008: anjum sohail; Qing Sun; Huiren Zhao; Maria Margarida Bernardo; Jin-Ah Cho; Rafael Fridman
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.
Cancer metastasis reviews 2008;27(2):289-302.
2007: Pratima Nangia-Makker; Tirza Raz; Larry Tait; Victor Hogan; Rafael Fridman; Avraham Raz
Galectin-3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancers.
Cancer research 2007;67(24):11760-8.
2007: Gabriel Rosenblum; Samy O Meroueh; Marta Toth; Jed F Fisher; Rafael Fridman; Shahriar Mobashery; Irit Sagi
Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma.
Journal of the American Chemical Society 2007;129(44):13566-74.
2007: Mijoon Lee; Adriel Villegas-Estrada; giuseppe celenza; Bill Boggess; Marta Toth; Gloria Kreitinger; Christopher Forbes; Rafael Fridman; Shahriar Mobashery; Mayland Chang
Metabolism of a highly selective gelatinase inhibitor generates active metabolite.
Chemical biology & drug design 2007;70(5):371-82.
2007: Yi I Wu; Hidayatullah Munshi; Scott J Snipas; Guy S Salvesen; Rafael Fridman; M Sharon Stack
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.
The Biochemical journal 2007;407(2):171-7.
2007: R Daniel Bonfil; Sreenivasa R Chinni; Rafael Fridman; Hyeong-Reh Choi Kim; Michael L Cher
Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis.
Urologic oncology 2007;25(5):407-11.
2007: Qing Sun; Christopher R Weber; anjum sohail; Maria Margarida Bernardo; Marta Toth; Huiren Zhao; Jerrold R Turner; Rafael Fridman
MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties.
The Journal of biological chemistry 2007;282(30):21998-2010.
2007: R Daniel Bonfil; Zhong Dong; J Carlos Trindade Filho; Aaron Sabbota; Pamela Osenkowski; Sanaa M Nabha; Hamilto Yamamoto; Sreenivasa R Chinni; Huiren Zhao; Shahriar Mobashery; Robert L Vessella; Rafael Fridman; Michael L Cher
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.
The American journal of pathology 2007;170(6):2100-11.
2007: Heather M McClung; Stacey L Thomas; Pamela Osenkowski; Marta Toth; Priya Menon; Avraham Raz; Rafael Fridman; Sandra Rempel
SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells.
Neuroscience letters 2007;419(2):172-7.
2007: Kulrut Borrirukwanit; Marc A Lafleur; Francesca A Mercuri; Tony Blick; John T Price; Rafael Fridman; Joseph J Pereira; Vijittra Leardkamonkarn; Erik W Thompson
The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(4):291-305.
2007: Catharine C Calkins; Julie Dosescu; Nancy A Day; Weiping Ren; Rafael Fridman; Bonnie F Sloane; Kamiar Moin
Functional expression of recombinant human stefin A in mammalian and bacterial cells.
Protein expression and purification 2007;52(2):463-71.
2006: Marta Toth; anjum sohail; Shahriar Mobashery; Rafael Fridman
MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts.
Biochemical and biophysical research communications 2006;350(2):377-84.
2006: Ki-Kyung Jung; Xu-Wen Liu; Rosemarie Chirco; Rafael Fridman; Hyeong-Reh Choi Kim
Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.
The EMBO journal 2006;25(17):3934-42.
2006: Dusan Hesek; Marta Toth; Viktor Krchnak; Rafael Fridman; Shahriar Mobashery
Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease.
The Journal of organic chemistry 2006;71(16):5848-54.
2006: R Daniel Bonfil; Aaron Sabbota; Sanaa M Nabha; Maria Margarida Bernardo; Zhong Dong; Hong Meng; Hamilto Yamamoto; Sreenivasa R Chinni; In Taek Lim; Mayland Chang; Lusia C Filetti; Shahriar Mobashery; Michael L Cher; Rafael Fridman
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor.
International journal of cancer. Journal international du cancer 2006;118(11):2721-6.
2006: Marcus E Taube; Xu-Wen Liu; Rafael Fridman; Hyeong-Reh Choi Kim
TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein.
Oncogene 2006;25(21):3041-8.
2006: Dusan Hesek; Marta Toth; Samy O Meroueh; Stephen Brown; Huiren Zhao; Wael A Sakr; Rafael Fridman; Shahriar Mobashery
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples.
Chemistry & biology 2006;13(4):379-86.
2006: Wilhelm J Lubbe; Zengyi Y Zhou; Weili Fu; David Zuzga; Stephanie Schulz; Rafael Fridman; Ruth J Muschel; Scott A Waldman; Giovanni M Pitari
Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1876-82.
2005: Masahiro Ikejiri; Maria Margarida Bernardo; R Daniel Bonfil; Marta Toth; Mayland Chang; Rafael Fridman; Shahriar Mobashery
Potent mechanism-based inhibitors for matrix metalloproteinases.
The Journal of biological chemistry 2005;280(40):33992-4002.
2005: Mijoon Lee; Maria Margarida Bernardo; Samy O Meroueh; Stephen Brown; Rafael Fridman; Shahriar Mobashery
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.
Organic letters 2005;7(20):4463-5.
2005: Pamela Osenkowski; Samy O Meroueh; Dumitru Pavel; Shahriar Mobashery; Rafael Fridman
Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing.
The Journal of biological chemistry 2005;280(28):26160-8.
2005: Masahiro Ikejiri; Maria Margarida Bernardo; Samy O Meroueh; Stephen Brown; Mayland Chang; Rafael Fridman; Shahriar Mobashery
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.
The Journal of organic chemistry 2005;70(14):5709-12.
2005: Zezong Gu; Jiankun Cui; Stephen Brown; Rafael Fridman; Shahriar Mobashery; Alex Y Strongin; Stuart A Lipton
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(27):6401-8.
2005: Gabriel Sosne; Patricia L Christopherson; Ronald Barrett; Rafael Fridman
Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury.
Investigative ophthalmology & visual science 2005;46(7):2388-95.
2005: Achim Krüger; Matthias J E Arlt; Michael Gerg; Charlotte Kopitz; Maria Margarida Bernardo; Mayland Chang; Shahriar Mobashery; Rafael Fridman
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.
Cancer research 2005;65(9):3523-6.
2005: Marta Toth; Pamela Osenkowski; Dusan Hesek; Stephen Brown; Samy O Meroueh; Wael A Sakr; Shahriar Mobashery; Rafael Fridman
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase.
The Biochemical journal 2005;387(Pt 2):497-506.
2005: Zhong Dong; R Daniel Bonfil; Sreenivasa R Chinni; Xiyun Deng; J Carlos Trindade Filho; Maria Margarida Bernardo; Ulka Nitin Vaishampayan; Mingxin Che; Bonnie F Sloane; Shijie Sheng; Rafael Fridman; Michael L Cher
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.
The American journal of pathology 2005;166(4):1173-86.
2005: Katia Bourd-Boittin; Rafael Fridman; Stéphanie Fanchon; Dominique Septier; Michel Goldberg; Suzanne Menashi
Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development.
Experimental cell research 2005;304(2):493-505.
2005: Xu-Wen Liu; Marcus E Taube; Ki-Kyung Jung; Zhong Dong; Yong J Lee; Stefanie Roshy; Bonnie F Sloane; Rafael Fridman; Hyeong-Reh Choi Kim
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1.
Cancer research 2005;65(3):898-906.
2004: Mijoon Lee; Rafael Fridman; Shahriar Mobashery
Extracellular proteases as targets for treatment of cancer metastases.
Chemical Society reviews 2004;33(7):401-9.
2004: Pamela Osenkowski; Marta Toth; Rafael Fridman
Processing, shedding, and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP).
Journal of cellular physiology 2004;200(1):2-10.
2004: Huiren Zhao; Maria Margarida Bernardo; Pamela Osenkowski; anjum sohail; Duanqing Pei; Hideaki Nagase; Masahide Kashiwagi; Paul D Soloway; Yves A DeClerck; Rafael Fridman
Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.
The Journal of biological chemistry 2004;279(10):8592-601.
2004: Yi I Wu; Hidayatullah Munshi; Ratna Sen; Scott J Snipas; Guy S Salvesen; Rafael Fridman; M Sharon Stack
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
The Journal of biological chemistry 2004;279(9):8278-89.
2004: Stephen Brown; Samy O Meroueh; Rafael Fridman; Shahriar Mobashery
Quest for selectivity in inhibition of matrix metalloproteinases.
Current topics in medicinal chemistry 2004;4(12):1227-38.
2004: R Daniel Bonfil; Pamela Osenkowski; Rafael Fridman; Michael L Cher
Matrix metalloproteinaes and bone metastasis.
Cancer treatment and research 2004;118():173-95.
2003: Xu-Wen Liu; Maria Margarida Bernardo; Rafael Fridman; Hyeong-Reh Choi Kim
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway.
The Journal of biological chemistry 2003;278(41):40364-72.
2003: Maria Margarida Bernardo; Rafael Fridman
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.
The Biochemical journal 2003;374(Pt 3):739-45.
2003: Marta Toth; Irina Chvyrkova; Maria Margarida Bernardo; Sonia Hernandez-Barrantes; Rafael Fridman
Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes.
Biochemical and biophysical research communications 2003;308(2):386-95.
2003: Gabriel Rosenblum; Samy O Meroueh; Oded Kleifeld; Stephen Brown; Steven P Singson; Rafael Fridman; Shahriar Mobashery; Irit Sagi
Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2).
The Journal of biological chemistry 2003;278(29):27009-15.
2003: Michael L Cher; Hector Biliran; Sunita Bhagat; Yonghong Meng; Mingxin Che; Jaron Lockett; Judith Abrams; Rafael Fridman; Michael Zachareas; Shijie Sheng
Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7847-52.
2003: Rafael Fridman; Marta Toth; Irina Chvyrkova; Samy O Meroueh; Shahriar Mobashery
Cell surface association of matrix metalloproteinase-9 (gelatinase B).
Cancer metastasis reviews 2003;22(2-3):153-66.
2003: Rafael Fridman
Surface association of secreted matrix metalloproteinases.
Current topics in developmental biology 2003;54():75-100.
2002: Lakshmi P Kotra; Li Zhang; Rafael Fridman; Ronald C Orlando; Shahriar Mobashery
N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9.
Bioorganic chemistry 2002;30(5):356-70.
2002: Marta Toth; Sonia Hernandez-Barrantes; Pamela Osenkowski; Maria Margarida Bernardo; David C Gervasi; Yoichiro Shimura; Oussama Meroueh; Lakshmi P Kotra; Beatriz G Gálvez; Alicia G Arroyo; Shahriar Mobashery; Rafael Fridman
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme.
The Journal of biological chemistry 2002;277(29):26340-50.
2002: Sonia Hernandez-Barrantes; Maria Margarida Bernardo; Marta Toth; Rafael Fridman
Regulation of membrane type-matrix metalloproteinases.
Seminars in cancer biology 2002;12(2):131-8.
2002: Maria Margarida Bernardo; Stephen Brown; Zhi-Hong Li; Rafael Fridman; Shahriar Mobashery
Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases.
The Journal of biological chemistry 2002;277(13):11201-7.
2002: Jeffrey A Nemeth; Rafid Yousif; Michael Herzog; Mingxin Che; Jyoti Upadhyay; Bijan Shekarriz; Sunita Bhagat; Chadwick Mullins; Rafael Fridman; Michael L Cher
Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis.
Journal of the National Cancer Institute 2002;94(1):17-25.
2001: Zhong Dong; Jeffrey A Nemeth; Michael L Cher; KC Palmer; R C Bright; Rafael Fridman
Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells.
International journal of cancer. Journal international du cancer 2001;93(4):507-15.
2001: Ernst Lengyel; Barbara Schmalfeldt; E Konik; K Späthe; K Härting; A Fenn; U Berger; Rafael Fridman; Manfred Schmitt; Dieter Prechtel; W Kuhn
Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer.
Gynecologic oncology 2001;82(2):291-8.
2001: Barbara Schmalfeldt; Dieter Prechtel; K Härting; K Späthe; Stephan Rutke; E Konik; Rafael Fridman; U Berger; Manfred Schmitt; W Kuhn; Ernst Lengyel
Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2396-404.
2001: Oded Kleifeld; Lakshmi P Kotra; David C Gervasi; Stephen Brown; Maria Margarida Bernardo; Rafael Fridman; Shahriar Mobashery; Irit Sagi
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme.
The Journal of biological chemistry 2001;276(20):17125-31.
2001: Lakshmi P Kotra; Jason B Cross; Yoichiro Shimura; Rafael Fridman; H Bernhard Schlegel; Shahriar Mobashery
Insight into the complex and dynamic process of activation of matrix metalloproteinases.
Journal of the American Chemical Society 2001;123(13):3108-13.
2001: Sonia Hernandez-Barrantes; Yoichiro Shimura; Paul D Soloway; Q A Sang; Rafael Fridman
Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP.
Biochemical and biophysical research communications 2001;281(1):126-30.
2001: Marta Toth; Rafael Fridman
Assessment of Gelatinases (MMP-2 and MMP-9 by Gelatin Zymography.
Methods in molecular medicine 2001;57():163-74.
2001: A Puyraimond; Rafael Fridman; Monique Lemesle; Brigitte Arbeille; Suzanne Menashi
MMP-2 colocalizes with caveolae on the surface of endothelial cells.
Experimental cell research 2001;262(1):28-36.
2000: Marta Toth; Maria Margarida Bernardo; David C Gervasi; Paul D Soloway; Zhijian Wang; Heather F Bigg; Christopher M Overall; Yves A DeClerck; H Tschesche; Michael L Cher; Stephen Brown; Shahriar Mobashery; Rafael Fridman
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
The Journal of biological chemistry 2000;275(52):41415-23.
2000: Zhong Dong; M Ghabrial; Malkhan Katar; Rafael Fridman; Richard S Berk
Membrane-type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa.
Investigative ophthalmology & visual science 2000;41(13):4189-94.
2000: Sonia Hernandez-Barrantes; Marta Toth; Maria Margarida Bernardo; M Yurkova; David C Gervasi; Y Raz; Q A Sang; Rafael Fridman
Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.
The Journal of biological chemistry 2000;275(16):12080-9.
2000: MW Olson; Maria Margarida Bernardo; M Pietila; David C Gervasi; Marta Toth; Lakshmi P Kotra; I Massova; Shahriar Mobashery; Rafael Fridman
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1.
The Journal of biological chemistry 2000;275(4):2661-8.
1999: G Li; Rafael Fridman; Hyeong-Reh Choi Kim
Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells.
Cancer research 1999;59(24):6267-75.
1999: Jyoti Upadhyay; Bijan Shekarriz; Jeffrey A Nemeth; Zhong Dong; G D Cummings; Rafael Fridman; Wael A Sakr; David Grignon; Michael L Cher
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4105-10.
1999: Marta Toth; Y Sado; Y Ninomiya; Rafael Fridman
Biosynthesis of alpha2(IV) and alpha1(IV) chains of collagen IV and interactions with matrix metalloproteinase-9.
Journal of cellular physiology 1999;180(1):131-9.
1998: Fernando J Bianco; David C Gervasi; Rabi Tiguert; David Grignon; J Edson Pontes; JD Crissman; Rafael Fridman; David P Wood Jr
Matrix metalloproteinase-9 expression in bladder washes from bladder cancer patients predicts pathological stage and grade.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):3011-6.
1998: I Massova; Lakshmi P Kotra; Rafael Fridman; Shahriar Mobashery
Matrix metalloproteinases: structures, evolution, and diversification.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(12):1075-95.
1998: MW Olson; Marta Toth; David C Gervasi; Y Sado; Y Ninomiya; Rafael Fridman
High affinity binding of latent matrix metalloproteinase-9 to the alpha2(IV) chain of collagen IV.
The Journal of biological chemistry 1998;273(17):10672-81.
1998: Suzanne Menashi; M Dehem; I Souliac; Y Legrand; Rafael Fridman
Density-dependent regulation of cell-surface association of matrix metalloproteinase-2 (MMP-2) in breast-carcinoma cells.
International journal of cancer. Journal international du cancer 1998;75(2):259-65.
1997: MW Olson; David C Gervasi; Shahriar Mobashery; Rafael Fridman
Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2.
The Journal of biological chemistry 1997;272(47):29975-83.
1997: Marta Toth; David C Gervasi; Rafael Fridman
Phorbol ester-induced cell surface association of matrix metalloproteinase-9 in human MCF10A breast epithelial cells.
Cancer research 1997;57(15):3159-67.
1997: Karen A Kernacki; Rafael Fridman; Linda D Hazlett; M A Lande; Richard S Berk
In vivo characterization of host and bacterial protease expression during Pseudomonas aeruginosa corneal infections in naive and immunized mice.
Current eye research 1997;16(4):289-97.
1997: S B Kondapaka; Rafael Fridman; Kaladhar B Reddy
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells.
International journal of cancer. Journal international du cancer 1997;70(6):722-6.
1996: David C Gervasi; Avraham Raz; M Dehem; M Yang; Markku T Kurkinen; Rafael Fridman
Carbohydrate-mediated regulation of matrix metalloproteinase-2 activation in normal human fibroblasts and fibrosarcoma cells.
Biochemical and biophysical research communications 1996;228(2):530-8.
1996: Weiping Ren; Rafael Fridman; J R Zabrecky; L D Morris; N A Day; Bonnie F Sloane
Expression of functional recombinant human procathepsin B in mammalian cells.
The Biochemical journal 1996;319 ( Pt 3)():793-800.
1996: E Levi; Rafael Fridman; HQ Miao; Y S Ma; A Yayon; Israel Vlodavsky
Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7069-74.
1996: David Grignon; Wael A Sakr; Marta Toth; V Ravery; J Angulo; Falah Shamsa; J Edson Pontes; JD Crissman; Rafael Fridman
High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer.
Cancer research 1996;56(7):1654-9.
1996: B F Liu; X Xu; Rafael Fridman; S Muallem; Tuan H Kuo
Consequences of functional expression of the plasma membrane Ca2+ pump isoform 1a.
The Journal of biological chemistry 1996;271(10):5536-44.
1995: Rafael Fridman; Marta Toth; D Peña; Shahriar Mobashery
Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).
Cancer research 1995;55(12):2548-55.
1995: Karen A Kernacki; Jeffery A Hobden; Linda D Hazlett; Rafael Fridman; Richard S Berk
In vivo bacterial protease production during Pseudomonas aeruginosa corneal infection.
Investigative ophthalmology & visual science 1995;36(7):1371-8.
1995: Suzanne Menashi; I Vlodavsky; R Ishai-Michaeli; Y Legrand; Rafael Fridman
The extracellular matrix produced by bovine corneal endothelial cells contains progelatinase A.
FEBS letters 1995;361(1):61-4.
1995: C Belloc; He Lu; Claudine Soria; Rafael Fridman; Y Legrand; Suzanne Menashi
The effect of platelets on invasiveness and protease production of human mammary tumor cells.
International journal of cancer. Journal international du cancer 1995;60(3):413-7.
1994: Alex Roher; T C Kasunic; Amina S Woods; Robert J Cotter; Melvyn Ball; Rafael Fridman
Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.
Biochemical and biophysical research communications 1994;205(3):1755-61.
1994: Josiah Ochieng; Rafael Fridman; Pratima Nangia-Makker; D E Kleiner; L A Liotta; William Stetler-Stevenson; Avraham Raz
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9.
Biochemistry 1994;33(47):14109-14.
1994: Daniel W Visscher; M Höyhtyä; S K Ottosen; C M Liang; Asfar S Azmi; JD Crissman; Rafael Fridman
Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence.
International journal of cancer. Journal international du cancer 1994;59(3):339-44.
1994: Suzanne Menashi; Rafael Fridman; S Desrivieres; He Lu; Y Legrand; Claudine Soria
Regulation of 92-kDa gelatinase B activity in the extracellular matrix by tissue kallikrein.
Annals of the New York Academy of Sciences 1994;732():466-8.
1994: M Höyhtyä; Rafael Fridman; D Komarek; K Porter-Jordan; William Stetler-Stevenson; L A Liotta; C M Liang
Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies.
International journal of cancer. Journal international du cancer 1994;56(4):500-5.
1993: J M Liebman; P D Burbelo; Y Yamada; Rafael Fridman; H K Kleinman
Altered expression of basement-membrane components and collagenases in ascitic xenografts of OVCAR-3 ovarian cancer cells.
International journal of cancer. Journal international du cancer 1993;55(1):102-9.
1993: H W Schnaper; Derrick S Grant; William Stetler-Stevenson; Rafael Fridman; G D'Orazi; A N Murphy; R E Bird; M Hoythya; Thomas R Fuerst; D L French
Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro.
Journal of cellular physiology 1993;156(2):235-46.
1993: Rafael Fridman; R E Bird; M Hoyhtya; M Oelkuct; D Komarek; C M Liang; M L Berman; L A Liotta; William Stetler-Stevenson; Thomas R Fuerst
Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme.
The Biochemical journal 1993;289 ( Pt 2)():411-6.
1992: Derrick S Grant; J L Kinsella; Rafael Fridman; R Auerbach; B A Piasecki; Yoshihiko Yamada; M Zain; Hynda K Kleinman
Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo.
Journal of cellular physiology 1992;153(3):614-25.
1992: Ann M Marini; Rafael Fridman; T Kanemoto; G R Martin; Y Guo; Antonino Passaniti
The neurotoxin 1-methyl-4-phenylpyridinium: a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties.
Journal of the National Cancer Institute 1992;84(20):1582-7.
1992: Rafael Fridman; Thomas R Fuerst; R E Bird; M Hoyhtya; M Oelkuct; S Kraus; D Komarek; L A Liotta; M L Berman; William Stetler-Stevenson
Domain structure of human 72-kDa gelatinase/type IV collagenase. Characterization of proteolytic activity and identification of the tissue inhibitor of metalloproteinase-2 (TIMP-2) binding regions.
The Journal of biological chemistry 1992;267(22):15398-405.
1992: Rafael Fridman; T M Sweeney; M Zain; G R Martin; Hynda K Kleinman
Malignant transformation of NIH-3T3 cells after subcutaneous co-injection with a reconstituted basement membrane (matrigel).
International journal of cancer. Journal international du cancer 1992;51(5):740-4.
1991: T M Sweeney; M C Kibbey; M Zain; Rafael Fridman; Hynda K Kleinman
Basement membrane and the SIKVAV laminin-derived peptide promote tumor growth and metastases.
Cancer metastasis reviews 1991;10(3):245-54.
1991: Rafael Fridman; M C Kibbey; L S Royce; M Zain; M Sweeney; D L Jicha; J R Yannelli; G R Martin; Hynda K Kleinman
Enhanced tumor growth of both primary and established human and murine tumor cells in athymic mice after coinjection with Matrigel.
Journal of the National Cancer Institute 1991;83(11):769-74.
1991: S Kubota; Rafael Fridman; Yoshihiko Yamada
Transforming growth factor-beta suppresses the invasiveness of human fibrosarcoma cells in vitro by increasing expression of tissue inhibitor of metalloprotease.
Biochemical and biophysical research communications 1991;176(1):129-36.
1991: T Kanemoto; G R Martin; T C Hamilton; Rafael Fridman
Effects of synthetic peptides and protease inhibitors on the interaction of a human ovarian cancer cell line (NIH:OVCAR-3) with a reconstituted basement membrane (Matrigel).
Invasion & metastasis 1991;11(2):84-92.
1990: Rafael Fridman; G Giaccone; T Kanemoto; G R Martin; Adi F Gazdar; J L Mulshine
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6698-702.
1990: Rafael Fridman; Alan F Scott; D Muller; R Reich; Margaret B Penno
The role of cell adhesion and migration in the in vitro invasiveness of mouse adrenal carcinoma cells.
Invasion & metastasis 1990;10(4):208-24.
1990: Rafael Fridman; Juan Carlos Lacal; Reuven Reich; R Daniel Bonfil; C H Ahn
Differential effects of phorbol ester on the in vitro invasiveness of malignant and non-malignant human fibroblast cells.
Journal of cellular physiology 1990;142(1):55-60.
1989: R Daniel Bonfil; S Momiki; Rafael Fridman; R Reich; Roger R Reddel; Curtis C Harris; A Klein-Szanto
Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by 12-O-tetradecanoyl-phorbol-13-acetate and diacylglycerol.
Carcinogenesis 1989;10(12):2335-8.
1989: Margaret B Penno; Antonino Passaniti; Rafael Fridman; Gerald W Hart; C Jordan; S Kumar; Alan F Scott
In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6057-61.
1989: Adriana Albini; S L Aukerman; R C Ogle; Douglas M Noonan; Rafael Fridman; G R Martin; I J Fidler
The in vitro invasiveness and interactions with laminin of K-1735 melanoma cells. Evidence for different laminin-binding affinities in high and low metastatic variants.
Clinical & experimental metastasis 1989;7(4):437-51.
1989: R Daniel Bonfil; Roger R Reddel; H Ura; R Reich; Rafael Fridman; Curtis C Harris; J P Klein-Szanto
Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line.
Journal of the National Cancer Institute 1989;81(8):587-94.
1988: Israel Vlodavsky; R I Michaeli; M Bar-Ner; Rafael Fridman; A T Horowitz; Z Fuks; S Biran
Involvement of heparanase in tumor metastasis and angiogenesis.
Israel journal of medical sciences 1988;24(9-10):464-70.
1988: Israel Vlodavsky; Amiram Eldor; M Bar-Ner; Rafael Fridman; I R Cohen; M Klagsbrun
Heparan sulfate degradation in tumor cell invasion and angiogenesis.
Advances in experimental medicine and biology 1988;233():201-10.
1987: I Vlodavsky; Rafael Fridman; R Sullivan; J Sasse; M Klagsbrun
Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet-derived growth factor-like protein which is secreted.
Journal of cellular physiology 1987;131(3):402-8.
1987: I Vlodavsky; J Folkman; R Sullivan; Rafael Fridman; R Ishai-Michaeli; J Sasse; M Klagsbrun
Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2292-6.
1987: Rafael Fridman; O Lider; Y Naparstek; Z Fuks; I Vlodavsky; I R Cohen
Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix.
Journal of cellular physiology 1987;130(1):85-92.
1985: A D Heyns; A Eldor; I Vlodavsky; N Kaiser; Rafael Fridman; A Panet
The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events. Studies with vascular smooth muscle cells and endothelial cells.
Experimental cell research 1985;161(2):297-306.
1985: Rafael Fridman; Y Alon; F Doljanski; Z Fuks; Israel Vlodavsky
Cell interaction with the extracellular matrices produced by endothelial cells and fibroblasts.
Experimental cell research 1985;158(2):461-76.
1985: Rafael Fridman; Z Fuks; H Ovadia; I Vlodavsky
Differential structural requirements for the induction of cell attachment, proliferation and differentiation by the extracellular matrix.
Experimental cell research 1985;157(1):181-94.
1984: H Ovadia; I Lubetzki-Korn; Talma Brenner; Oded Abramsky; Rafael Fridman; I Vlodavsky
Adult rat oligodendrocytes grown in vitro upon an extracellular matrix have the ability to proliferate.
Brain research 1984;322(1):93-100.
1984: Amiram Eldor; Rafael Fridman; Israel Vlodavsky; E Hy-Am; Z Fuks; Amos Panet
Interferon enhances prostacyclin production by cultured vascular endothelial cells.
The Journal of clinical investigation 1984;73(1):251-7.