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Rafael Fridman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Mice

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Enzyme Activation

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Co-Publications
Name
33
Mobashery, Shahriar
25
Toth, Marta
18
Bernardo, Maria Margarida
11
Cher, Michael
10
Gervasi, David
10
Bonfil, Daniel
9
Meroueh, Samy
9
Osenkowski, Pamela
7
Dong, Zhong
7
Chang, Mayland
6
Hesek, Dusan
6
Kim, Hyeong-Reh Choi
6
Kotra, Lakshmi
6
Lee, Mijoon
6
Menashi, Suzanne

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Publications

TOP 3
Gooyit Major; Lee Mijoon; Hesek Dusan; Boggess Bill; Oliver Allen G; Fridman Rafael; Mobashery Shahriar; Chang Mayland
Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.
Forbes Christopher; Shi Qicun; Fisher Jed F; Lee Mijoon; Hesek Dusan; Llarrull Leticia I; Toth Marta; Gossing Michael; Fridman Rafael; Mobashery Shahriar
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
Lee Mijoon; Celenza Giuseppe; Boggess Bill; Blase Jennifer; Shi Qicun; Toth Marta; Bernardo M Margarida; Wolter William R; Suckow Mark A; Hesek Dusan; Noll Bruce C; Fridman Rafael; Mobashery Shahriar; Chang Mayland
A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.

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All Publications

2009: Gooyit Major; Lee Mijoon; Hesek Dusan; Boggess Bill; Oliver Allen G; Fridman Rafael; Mobashery Shahriar; Chang Mayland
Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors.
Chemical biology & drug design 2009;74(6):535-46.
2009: Forbes Christopher; Shi Qicun; Fisher Jed F; Lee Mijoon; Hesek Dusan; Llarrull Leticia I; Toth Marta; Gossing Michael; Fridman Rafael; Mobashery Shahriar
Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases.
Chemical biology & drug design 2009;74(6):527-34.
2009: Lee Mijoon; Celenza Giuseppe; Boggess Bill; Blase Jennifer; Shi Qicun; Toth Marta; Bernardo M Margarida; Wolter William R; Suckow Mark A; Hesek Dusan; Noll Bruce C; Fridman Rafael; Mobashery Shahriar; Chang Mayland
A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.
Chemical biology & drug design 2009;73(2):189-202.
2008: Zhao Huiren; Sohail Anjum; Sun Qing; Shi Qicun; Kim Seaho; Mobashery Shahriar; Fridman Rafael
Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25).
The Journal of biological chemistry 2008;283(50):35023-32.
2008: Xu Danmei; Suenaga Naoko; Edelmann Mariola J; Fridman Rafael; Muschel Ruth J; Kessler Benedikt M
Novel MMP-9 substrates in cancer cells revealed by a label-free quantitative proteomics approach.
Molecular & cellular proteomics : MCP 2008;7(11):2215-28.
2008: Bonfil R D; Fridman R; Mobashery S; Cher M L
Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis?
Current oncology (Toronto, Ont.) 2008;15(4):188-92.
2008: Cho Jin-Ah; Osenkowski Pamela; Zhao Huiren; Kim Seaho; Toth Marta; Cole Kristina; Aboukameel Amro; Saliganan Allen; Schuger Lucia; Bonfil R Daniel; Fridman Rafael
The inactive 44-kDa processed form of membrane type 1 matrix metalloproteinase (MT1-MMP) enhances proteolytic activity via regulation of endocytosis of active MT1-MMP.
The Journal of biological chemistry 2008;283(25):17391-405.
2008: Sohail Anjum; Sun Qing; Zhao Huiren; Bernardo M Margarida; Cho Jin-Ah; Fridman Rafael
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.
Cancer metastasis reviews 2008;27(2):289-302.
2007: Nangia-Makker Pratima; Raz Tirza; Tait Larry; Hogan Victor; Fridman Rafael; Raz Avraham
Galectin-3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancers.
Cancer research 2007;67(24):11760-8.
2007: Rosenblum Gabriel; Meroueh Samy; Toth Marta; Fisher Jed F; Fridman Rafael; Mobashery Shahriar; Sagi Irit
Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma.
Journal of the American Chemical Society 2007;129(44):13566-74.
2007: Lee Mijoon; Villegas-Estrada Adriel; Celenza Giuseppe; Boggess Bill; Toth Marta; Kreitinger Gloria; Forbes Christopher; Fridman Rafael; Mobashery Shahriar; Chang Mayland
Metabolism of a highly selective gelatinase inhibitor generates active metabolite.
Chemical biology & drug design 2007;70(5):371-82.
2007: Wu Yi I; Munshi Hidayatullah G; Snipas Scott J; Salvesen Guy S; Fridman Rafael; Stack M Sharon
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.
The Biochemical journal 2007;407(2):171-7.
2007: Bonfil R Daniel; Chinni Sreenivasa; Fridman Rafael; Kim Hyeong-Reh; Cher Michael L
Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis.
Urologic oncology 2007;25(5):407-11.
2007: Sun Qing; Weber Christopher R; Sohail Anjum; Bernardo M Margarida; Toth Marta; Zhao Huiren; Turner Jerrold R; Fridman Rafael
MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties.
The Journal of biological chemistry 2007;282(30):21998-2010.
2007: Bonfil R Daniel; Dong Zhong; Trindade Filho J Carlos; Sabbota Aaron; Osenkowski Pamela; Nabha Sanaa; Yamamoto Hamilto; Chinni Sreenivasa R; Zhao Huiren; Mobashery Shahriar; Vessella Robert L; Fridman Rafael; Cher Michael L
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.
The American journal of pathology 2007;170(6):2100-11.
2007: McClung Heather M; Thomas Stacey L; Osenkowski Pamela; Toth Marta; Menon Priya; Raz Avraham; Fridman Rafael; Rempel Sandra A
SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells.
Neuroscience letters 2007;419(2):172-7.
2007: Borrirukwanit Kulrut; Lafleur Marc A; Mercuri Francesca A; Blick Tony; Price John T; Fridman Rafael; Pereira Joseph J; Leardkamonkarn Vijittra; Thompson Erik W
The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by alphaVbeta3 integrin in human breast cancer cells.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(4):291-305.
2007: Calkins Catharine C; Dosescu Julie; Day Nancy A; Ren Wei-Ping; Fridman Rafael; Sloane Bonnie F; Moin Kamiar
Functional expression of recombinant human stefin A in mammalian and bacterial cells.
Protein expression and purification 2007;52(2):463-71.
2006: Toth Marta; Sohail Anjum; Mobashery Shahriar; Fridman Rafael
MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts.
Biochemical and biophysical research communications 2006;350(2):377-84.
2006: Jung Ki-Kyung; Liu Xu-Wen; Chirco Rosemarie; Fridman Rafael; Kim Hyeong-Reh Choi
Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein.
The EMBO journal 2006;25(17):3934-42.
2006: Hesek Dusan; Toth Marta; Krchnak Viktor; Fridman Rafael; Mobashery Shahriar
Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease.
The Journal of organic chemistry 2006;71(16):5848-54.
2006: Bonfil R Daniel; Sabbota Aaron; Nabha Sanaa; Bernardo M Margarida; Dong Zhong; Meng Hong; Yamamoto Hamilto; Chinni Sreenivasa R; Lim Int Taek; Chang Mayland; Filetti Lusia C; Mobashery Shahriar; Cher Michael L; Fridman Rafael
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor.
International journal of cancer. Journal international du cancer 2006;118(11):2721-6.
2006: Taube M E; Liu X-W; Fridman R; Kim H-R C
TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein.
Oncogene 2006;25(21):3041-8.
2006: Hesek Dusan; Toth Marta; Meroueh Samy O; Brown Stephen; Zhao Huiren; Sakr Wael; Fridman Rafael; Mobashery Shahriar
Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples.
Chemistry & biology 2006;13(4):379-86.
2006: Lubbe Wilhelm J; Zhou Zengyi Y; Fu Weili; Zuzga David; Schulz Stephanie; Fridman Rafael; Muschel Ruth J; Waldman Scott A; Pitari Giovanni M
Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1876-82.
2005: Ikejiri Masahiro; Bernardo M Margarida; Bonfil R Daniel; Toth Marta; Chang Mayland; Fridman Rafael; Mobashery Shahriar
Potent mechanism-based inhibitors for matrix metalloproteinases.
The Journal of biological chemistry 2005;280(40):33992-4002.
2005: Lee Mijoon; Bernardo M Margarida; Meroueh Samy O; Brown Stephen; Fridman Rafael; Mobashery Shahriar
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.
Organic letters 2005;7(20):4463-5.
2005: Gu Zezong; Cui Jiankun; Brown Stephen; Fridman Rafael; Mobashery Shahriar; Strongin Alex Y; Lipton Stuart A
A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(27):6401-8.
2005: Ikejiri Masahiro; Bernardo M Margarida; Meroueh Samy O; Brown Stephen; Chang Mayland; Fridman Rafael; Mobashery Shahriar
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.
The Journal of organic chemistry 2005;70(14):5709-12.
2005: Sosne Gabriel; Christopherson Patricia L; Barrett Ronald P; Fridman Rafael
Thymosin-beta4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury.
Investigative ophthalmology & visual science 2005;46(7):2388-95.
2005: Osenkowski Pamela; Meroueh Samy O; Pavel Dumitru; Mobashery Shahriar; Fridman Rafael
Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing.
The Journal of biological chemistry 2005;280(28):26160-8.
2005: Krüger Achim; Arlt Matthias J E; Gerg Michael; Kopitz Charlotte; Bernardo M Margarida; Chang Mayland; Mobashery Shahriar; Fridman Rafael
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.
Cancer research 2005;65(9):3523-6.
2005: Dong Zhong; Bonfil R Daniel; Chinni Sreenivasa; Deng Xiyun; Trindade Filho J Carlos; Bernardo Margarida; Vaishampayan Ulka; Che Mingxin; Sloane Bonnie F; Sheng Shijie; Fridman Rafael; Cher Michael L
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.
The American journal of pathology 2005;166(4):1173-86.
2005: Bourd-Boittin Katia; Fridman Rafael; Fanchon Stéphanie; Septier Dominique; Goldberg Michel; Menashi Suzanne
Matrix metalloproteinase inhibition impairs the processing, formation and mineralization of dental tissues during mouse molar development.
Experimental cell research 2005;304(2):493-505.
2005: Toth Marta; Osenkowski Pamela; Hesek Dusan; Brown Stephen; Meroueh Samy; Sakr Wael; Mobashery Shahriar; Fridman Rafael
Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase.
The Biochemical journal 2005;387(Pt 2):497-506.
2005: Liu Xu-Wen; Taube Marcus E; Jung Ki-Kyung; Dong Zhong; Lee Yong J; Roshy Stefanie; Sloane Bonnie F; Fridman Rafael; Kim Hyeong-Reh Choi
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1.
Cancer research 2005;65(3):898-906.
2004: Lee Mijoon; Fridman Rafael; Mobashery Shahriar
Extracellular proteases as targets for treatment of cancer metastases.
Chemical Society reviews 2004;33(7):401-9.
2004: Osenkowski Pamela; Toth Marta; Fridman Rafael
Processing, shedding, and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP).
Journal of cellular physiology 2004;200(1):2-10.
2004: Zhao Huiren; Bernardo M Margarida; Osenkowski Pamela; Sohail Anjum; Pei Duanqing; Nagase Hideaki; Kashiwagi Masahide; Soloway Paul D; DeClerck Yves A; Fridman Rafael
Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.
The Journal of biological chemistry 2004;279(10):8592-601.
2004: Wu Yi I; Munshi Hidayatullah G; Sen Ratna; Snipas Scott J; Salvesen Guy S; Fridman Rafael; Stack M Sharon
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
The Journal of biological chemistry 2004;279(9):8278-89.
2004: Brown Stephen; Meroueh Samy O; Fridman Rafael; Mobashery Shahriar
Quest for selectivity in inhibition of matrix metalloproteinases.
Current topics in medicinal chemistry 2004;4(12):1227-38.
2004: Bonfil R Daniel; Osenkowski Pamela; Fridman Rafael; Cher Michael L
Matrix metalloproteinaes and bone metastasis.
Cancer treatment and research 2004;118():173-95.
2003: Liu Xu-Wen; Bernardo M Margarida; Fridman Rafael; Kim Hyeong-Reh Choi
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway.
The Journal of biological chemistry 2003;278(41):40364-72.
2003: Bernardo M Margarida; Fridman Rafael
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.
The Biochemical journal 2003;374(Pt 3):739-45.
2003: Toth Marta; Chvyrkova Irina; Bernardo M Margarida; Hernandez-Barrantes Sonia; Fridman Rafael
Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes.
Biochemical and biophysical research communications 2003;308(2):386-95.
2003: Rosenblum Gabriel; Meroueh Samy O; Kleifeld Oded; Brown Stephen; Singson Steven P; Fridman Rafael; Mobashery Shahriar; Sagi Irit
Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2).
The Journal of biological chemistry 2003;278(29):27009-15.
2003: Cher Michael L; Biliran Hector R; Bhagat Sunita; Meng Yonghong; Che Mingxin; Lockett Jaron; Abrams Judith; Fridman Rafael; Zachareas Michael; Sheng Shijie
Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7847-52.
2003: Fridman Rafael; Toth Marta; Chvyrkova Irina; Meroueh Samy O; Mobashery Shahriar
Cell surface association of matrix metalloproteinase-9 (gelatinase B).
Cancer metastasis reviews 2003;22(2-3):153-66.
2003: Fridman Rafael
Surface association of secreted matrix metalloproteinases.
Current topics in developmental biology 2003;54():75-100.
2002: Kotra Lakshmi P; Zhang Li; Fridman Rafael; Orlando Ron; Mobashery Shahriar
N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9.
Bioorganic chemistry 2002;30(5):356-70.
2002: Toth Marta; Hernandez-Barrantes Sonia; Osenkowski Pamela; Bernardo M Margarida; Gervasi David C; Shimura Yoichiro; Meroueh Oussama; Kotra Lakshmi P; Gálvez Beatriz G; Arroyo Alicia G; Mobashery Shahriar; Fridman Rafael
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme.
The Journal of biological chemistry 2002;277(29):26340-50.
2002: Hernandez-Barrantes Sonia; Bernardo Margarida; Toth Marta; Fridman Rafael
Regulation of membrane type-matrix metalloproteinases.
Seminars in cancer biology 2002;12(2):131-8.
2002: Bernardo M Margarida; Brown Stephen; Li Zhi-Hong; Fridman Rafael; Mobashery Shahriar
Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases.
The Journal of biological chemistry 2002;277(13):11201-7.
2002: Nemeth Jeffrey A; Yousif Rafid; Herzog Michael; Che Mingxin; Upadhyay Jyoti; Shekarriz Bijan; Bhagat Sunita; Mullins Chadwick; Fridman Rafael; Cher Michael L
Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis.
Journal of the National Cancer Institute 2002;94(1):17-25.
2001: Lengyel E; Schmalfeldt B; Konik E; Späthe K; Härting K; Fenn A; Berger U; Fridman R; Schmitt M; Prechtel D; Kuhn W
Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer.
Gynecologic oncology 2001;82(2):291-8.
2001: Schmalfeldt B; Prechtel D; Härting K; Späthe K; Rutke S; Konik E; Fridman R; Berger U; Schmitt M; Kuhn W; Lengyel E
Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2396-404.
2001: Dong Z; Nemeth J A; Cher M L; Palmer K C; Bright R C; Fridman R
Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells.
International journal of cancer. Journal international du cancer 2001;93(4):507-15.
2001: Kleifeld O; Kotra L P; Gervasi D C; Brown S; Bernardo M M; Fridman R; Mobashery S; Sagi I
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme.
The Journal of biological chemistry 2001;276(20):17125-31.
2001: Kotra L P; Cross J B; Shimura Y; Fridman R; Schlegel H B; Mobashery S
Insight into the complex and dynamic process of activation of matrix metalloproteinases.
Journal of the American Chemical Society 2001;123(13):3108-13.
2001: Hernandez-Barrantes S; Shimura Y; Soloway P D; Sang Q A; Fridman R
Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP.
Biochemical and biophysical research communications 2001;281(1):126-30.
2001: Puyraimond A; Fridman R; Lemesle M; Arbeille B; Menashi S
MMP-2 colocalizes with caveolae on the surface of endothelial cells.
Experimental cell research 2001;262(1):28-36.
2000: Dong Z; Ghabrial M; Katar M; Fridman R; Berk R S
Membrane-type matrix metalloproteinases in mice intracorneally infected with Pseudomonas aeruginosa.
Investigative ophthalmology & visual science 2000;41(13):4189-94.
2000: Toth M; Bernardo M M; Gervasi D C; Soloway P D; Wang Z; Bigg H F; Overall C M; DeClerck Y A; Tschesche H; Cher M L; Brown S; Mobashery S; Fridman R
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
The Journal of biological chemistry 2000;275(52):41415-23.
2000: Hernandez-Barrantes S; Toth M; Bernardo M M; Yurkova M; Gervasi D C; Raz Y; Sang Q A; Fridman R
Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.
The Journal of biological chemistry 2000;275(16):12080-9.
2000: Olson M W; Bernardo M M; Pietila M; Gervasi D C; Toth M; Kotra L P; Massova I; Mobashery S; Fridman R
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1.
The Journal of biological chemistry 2000;275(4):2661-8.
1999: Upadhyay J; Shekarriz B; Nemeth J A; Dong Z; Cummings G D; Fridman R; Sakr W; Grignon D J; Cher M L
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4105-10.
1999: Li G; Fridman R; Kim H R
Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells.
Cancer research 1999;59(24):6267-75.
1999: Toth M; Sado Y; Ninomiya Y; Fridman R
Biosynthesis of alpha2(IV) and alpha1(IV) chains of collagen IV and interactions with matrix metalloproteinase-9.
Journal of cellular physiology 1999;180(1):131-9.
1998: Bianco F J; Gervasi D C; Tiguert R; Grignon D J; Pontes J E; Crissman J D; Fridman R; Wood D P
Matrix metalloproteinase-9 expression in bladder washes from bladder cancer patients predicts pathological stage and grade.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):3011-6.
1998: Massova I; Kotra L P; Fridman R; Mobashery S
Matrix metalloproteinases: structures, evolution, and diversification.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(12):1075-95.
1998: Olson M W; Toth M; Gervasi D C; Sado Y; Ninomiya Y; Fridman R
High affinity binding of latent matrix metalloproteinase-9 to the alpha2(IV) chain of collagen IV.
The Journal of biological chemistry 1998;273(17):10672-81.
1998: Menashi S; Dehem M; Souliac I; Legrand Y; Fridman R
Density-dependent regulation of cell-surface association of matrix metalloproteinase-2 (MMP-2) in breast-carcinoma cells.
International journal of cancer. Journal international du cancer 1998;75(2):259-65.
1997: Olson M W; Gervasi D C; Mobashery S; Fridman R
Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2.
The Journal of biological chemistry 1997;272(47):29975-83.
1997: Toth M; Gervasi D C; Fridman R
Phorbol ester-induced cell surface association of matrix metalloproteinase-9 in human MCF10A breast epithelial cells.
Cancer research 1997;57(15):3159-67.
1997: Kernacki K A; Fridman R; Hazlett L D; Lande M A; Berk R S
In vivo characterization of host and bacterial protease expression during Pseudomonas aeruginosa corneal infections in naive and immunized mice.
Current eye research 1997;16(4):289-97.
1997: Kondapaka S B; Fridman R; Reddy K B
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells.
International journal of cancer. Journal international du cancer 1997;70(6):722-6.
1996: Ren W P; Fridman R; Zabrecky J R; Morris L D; Day N A; Sloane B F
Expression of functional recombinant human procathepsin B in mammalian cells.
The Biochemical journal 1996;319 ( Pt 3)():793-800.
1996: Gervasi D C; Raz A; Dehem M; Yang M; Kurkinen M; Fridman R
Carbohydrate-mediated regulation of matrix metalloproteinase-2 activation in normal human fibroblasts and fibrosarcoma cells.
Biochemical and biophysical research communications 1996;228(2):530-8.
1996: Levi E; Fridman R; Miao H Q; Ma Y S; Yayon A; Vlodavsky I
Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7069-74.
1996: Grignon D J; Sakr W; Toth M; Ravery V; Angulo J; Shamsa F; Pontes J E; Crissman J C; Fridman R
High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer.
Cancer research 1996;56(7):1654-9.
1996: Liu B F; Xu X; Fridman R; Muallem S; Kuo T H
Consequences of functional expression of the plasma membrane Ca2+ pump isoform 1a.
The Journal of biological chemistry 1996;271(10):5536-44.
1995: Fridman R; Toth M; Peña D; Mobashery S
Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).
Cancer research 1995;55(12):2548-55.
1995: Kernacki K A; Hobden J A; Hazlett L D; Fridman R; Berk R S
In vivo bacterial protease production during Pseudomonas aeruginosa corneal infection.
Investigative ophthalmology & visual science 1995;36(7):1371-8.
1995: Menashi S; Vlodavsky I; Ishai-Michaeli R; Legrand Y; Fridman R
The extracellular matrix produced by bovine corneal endothelial cells contains progelatinase A.
FEBS letters 1995;361(1):61-4.
1995: Belloc C; Lu H; Soria C; Fridman R; Legrand Y; Menashi S
The effect of platelets on invasiveness and protease production of human mammary tumor cells.
International journal of cancer. Journal international du cancer 1995;60(3):413-7.
1994: Roher A E; Kasunic T C; Woods A S; Cotter R J; Ball M J; Fridman R
Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A.
Biochemical and biophysical research communications 1994;205(3):1755-61.
1994: Ochieng J; Fridman R; Nangia-Makker P; Kleiner D E; Liotta L A; Stetler-Stevenson W G; Raz A
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9.
Biochemistry 1994;33(47):14109-14.
1994: Visscher D W; Höyhtyä M; Ottosen S K; Liang C M; Sarkar F H; Crissman J D; Fridman R
Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence.
International journal of cancer. Journal international du cancer 1994;59(3):339-44.
1994: Menashi S; Fridman R; Desrivieres S; Lu H; Legrand Y; Soria C
Regulation of 92-kDa gelatinase B activity in the extracellular matrix by tissue kallikrein.
Annals of the New York Academy of Sciences 1994;732():466-8.
1994: Höyhtyä M; Fridman R; Komarek D; Porter-Jordan K; Stetler-Stevenson W G; Liotta L A; Liang C M
Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies.
International journal of cancer. Journal international du cancer 1994;56(4):500-5.
1993: Schnaper H W; Grant D S; Stetler-Stevenson W G; Fridman R; D'Orazi G; Murphy A N; Bird R E; Hoythya M; Fuerst T R; French D L
Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro.
Journal of cellular physiology 1993;156(2):235-46.
1993: Fridman R; Bird R E; Hoyhtya M; Oelkuct M; Komarek D; Liang C M; Berman M L; Liotta L A; Stetler-Stevenson W G; Fuerst T R
Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme.
The Biochemical journal 1993;289 ( Pt 2)():411-6.
1992: Grant D S; Kinsella J L; Fridman R; Auerbach R; Piasecki B A; Yamada Y; Zain M; Kleinman H K
Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo.
Journal of cellular physiology 1992;153(3):614-25.
1992: Marini A M; Fridman R; Kanemoto T; Martin G R; Guo Y; Passaniti A
The neurotoxin 1-methyl-4-phenylpyridinium: a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties.
Journal of the National Cancer Institute 1992;84(20):1582-7.
1992: Fridman R; Fuerst T R; Bird R E; Hoyhtya M; Oelkuct M; Kraus S; Komarek D; Liotta L A; Berman M L; Stetler-Stevenson W G
Domain structure of human 72-kDa gelatinase/type IV collagenase. Characterization of proteolytic activity and identification of the tissue inhibitor of metalloproteinase-2 (TIMP-2) binding regions.
The Journal of biological chemistry 1992;267(22):15398-405.
1992: Fridman R; Sweeney T M; Zain M; Martin G R; Kleinman H K
Malignant transformation of NIH-3T3 cells after subcutaneous co-injection with a reconstituted basement membrane (matrigel).
International journal of cancer. Journal international du cancer 1992;51(5):740-4.
1991: Sweeney T M; Kibbey M C; Zain M; Fridman R; Kleinman H K
Basement membrane and the SIKVAV laminin-derived peptide promote tumor growth and metastases.
Cancer metastasis reviews 1991;10(3):245-54.
1991: Fridman R; Kibbey M C; Royce L S; Zain M; Sweeney M; Jicha D L; Yannelli J R; Martin G R; Kleinman H K
Enhanced tumor growth of both primary and established human and murine tumor cells in athymic mice after coinjection with Matrigel.
Journal of the National Cancer Institute 1991;83(11):769-74.
1991: Kubota S; Fridman R; Yamada Y
Transforming growth factor-beta suppresses the invasiveness of human fibrosarcoma cells in vitro by increasing expression of tissue inhibitor of metalloprotease.
Biochemical and biophysical research communications 1991;176(1):129-36.
1991: Kanemoto T; Martin G R; Hamilton T C; Fridman R
Effects of synthetic peptides and protease inhibitors on the interaction of a human ovarian cancer cell line (NIH:OVCAR-3) with a reconstituted basement membrane (Matrigel).
Invasion & metastasis 1991;11(2):84-92.
1990: Fridman R; Giaccone G; Kanemoto T; Martin G R; Gazdar A F; Mulshine J L
Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6698-702.
1990: Fridman R; Lacal J C; Reich R; Bonfil D R; Ahn C H
Differential effects of phorbol ester on the in vitro invasiveness of malignant and non-malignant human fibroblast cells.
Journal of cellular physiology 1990;142(1):55-60.
1990: Fridman R; Scott A F; Muller D; Reich R; Penno M B
The role of cell adhesion and migration in the in vitro invasiveness of mouse adrenal carcinoma cells.
Invasion & metastasis 1990;10(4):208-24.
1989: Bonfil R D; Momiki S; Fridman R; Reich R; Reddel R; Harris C C; Klein-Szanto A
Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by 12-O-tetradecanoyl-phorbol-13-acetate and diacylglycerol.
Carcinogenesis 1989;10(12):2335-8.
1989: Penno M B; Passaniti A; Fridman R; Hart G W; Jordan C; Kumar S; Scott A F
In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6057-61.
1989: Albini A; Aukerman S L; Ogle R C; Noonan D M; Fridman R; Martin G R; Fidler I J
The in vitro invasiveness and interactions with laminin of K-1735 melanoma cells. Evidence for different laminin-binding affinities in high and low metastatic variants.
Clinical & experimental metastasis 1989;7(4):437-51.
1989: Bonfil R D; Reddel R R; Ura H; Reich R; Fridman R; Harris C C; Klein-Szanto J P
Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line.
Journal of the National Cancer Institute 1989;81(8):587-94.
1988: Vlodavsky I; Michaeli R I; Bar-Ner M; Fridman R; Horowitz A T; Fuks Z; Biran S
Involvement of heparanase in tumor metastasis and angiogenesis.
Israel journal of medical sciences 1988;24(9-10):464-70.
1988: Vlodavsky I; Eldor A; Bar-Ner M; Fridman R; Cohen I R; Klagsbrun M
Heparan sulfate degradation in tumor cell invasion and angiogenesis.
Advances in experimental medicine and biology 1988;233():201-10.
1987: Vlodavsky I; Fridman R; Sullivan R; Sasse J; Klagsbrun M
Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet-derived growth factor-like protein which is secreted.
Journal of cellular physiology 1987;131(3):402-8.
1987: Vlodavsky I; Folkman J; Sullivan R; Fridman R; Ishai-Michaeli R; Sasse J; Klagsbrun M
Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2292-6.
1987: Fridman R; Lider O; Naparstek Y; Fuks Z; Vlodavsky I; Cohen I R
Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix.
Journal of cellular physiology 1987;130(1):85-92.
1985: Heyns A D; Eldor A; Vlodavsky I; Kaiser N; Fridman R; Panet A
The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events. Studies with vascular smooth muscle cells and endothelial cells.
Experimental cell research 1985;161(2):297-306.
1985: Fridman R; Alon Y; Doljanski F; Fuks Z; Vlodavsky I
Cell interaction with the extracellular matrices produced by endothelial cells and fibroblasts.
Experimental cell research 1985;158(2):461-76.
1985: Fridman R; Fuks Z; Ovadia H; Vlodavsky I
Differential structural requirements for the induction of cell attachment, proliferation and differentiation by the extracellular matrix.
Experimental cell research 1985;157(1):181-94.
1984: Ovadia H; Lubetzki-Korn I; Brenner T; Abramsky O; Fridman R; Vlodavsky I
Adult rat oligodendrocytes grown in vitro upon an extracellular matrix have the ability to proliferate.
Brain research 1984;322(1):93-100.
1984: Eldor A; Fridman R; Vlodavsky I; Hy-Am E; Fuks Z; Panet A
Interferon enhances prostacyclin production by cultured vascular endothelial cells.
The Journal of clinical investigation 1984;73(1):251-7.

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