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Assaf Friedler

Research Profile

Phenomena

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HIV-1

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Publications

TOP 3
Shlomit Guy; Zvi Hayouka; Aviad Levin; Abraham Loyter; Danny Porath; Dvir Rotem; Limor Zemel; Ronen Gabizon; Assaf Friedler
Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system.
Masha M Rosenberg; N Lahav; Elvira Nazirov; Shoshana Ravid; Denise Ronen; Assaf Friedler
High resolution characterization of myosin IIC protein tailpiece and its effect on filament assembly.
Shahar Rotem-Bamberger; Chen Katz; Assaf Friedler
Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism.

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All Publications

2013: Shlomit Guy; Zvi Hayouka; Aviad Levin; Abraham Loyter; Danny Porath; Dvir Rotem; Limor Zemel; Ronen Gabizon; Assaf Friedler
Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system.
Chemical communications (Cambridge, England) 2013;49(30):3113-5.
2013: Masha M Rosenberg; N Lahav; Elvira Nazirov; Shoshana Ravid; Denise Ronen; Assaf Friedler
High resolution characterization of myosin IIC protein tailpiece and its effect on filament assembly.
The Journal of biological chemistry 2013;288(14):9779-89.
2013: Shahar Rotem-Bamberger; Chen Katz; Assaf Friedler
Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism.
PloS one 2013;8(3):e58470.
2012: Michal Maes; Abraham Loyter; Assaf Friedler
Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions.
The FEBS journal 2012;279(16):2795-809.
2012: Zvi Hayouka; Mattan Hurevich; Aviad Levin; Abraham Loyter; Deborah E Shalev; Chaim Gilon; Assaf Friedler
A comparative study of backbone versus side chain peptide cyclization: application for HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry 2012;20(10):3317-22.
2012: Natalia Edison; Assaf Friedler; Yossi Gottfried; Tali Lev; Inbal Maniv; tali Reingewertz; Gil Shalev; Dotan Zuri; Marie-Jeanne Carp; Sarit Larisch
Peptides mimicking the unique ARTS-XIAP binding site promote apoptotic cell death in cultured cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(9):2569-78.
2012: Chen Katz; Neta Kollet; Yana Mostizky; Yehudit Zaltsman-Amir; Atan Gross; Assaf Friedler
Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway.
The Journal of biological chemistry 2012;287(18):15016-23.
2012: Ronen Gabizon; N Lahav; Mario Lebendiker; Deborah E Shalev; Shahar Sukenik; Dmitry B Veprintsev; Tobias Brandt; Assaf Friedler
Specific recognition of p53 tetramers by peptides derived from p53 interacting proteins.
PloS one 2012;7(5):e38060.
2011: Chen Katz; Liron Levy-Beladev; Shahar Rotem-Bamberger; Tiago Rito; Stefan G D Rüdiger; Assaf Friedler
Studying protein-protein interactions using peptide arrays.
Chemical Society reviews 2011;40(5):2131-45.
2011: Efrat Flashner; Uri Raviv; Assaf Friedler
The effect of tachykinin neuropeptides on amyloid β aggregation.
Biochemical and biophysical research communications 2011;407(1):13-7.
2011: Hadar Benyamini; Assaf Friedler
The ASPP interaction network: electrostatic differentiation between pro- and anti-apoptotic proteins.
Journal of molecular recognition : JMR 2011;24(2):266-74.
2011: tali Reingewertz; Shahar Rotem-Bamberger; Deborah E Shalev; Shahar Sukenik; Ofrah Blatt; Sarit Larisch; Mario Lebendiker; Assaf Friedler
Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP.
PloS one 2011;6(9):e24655.
2011: Shahar Sukenik; Regina Politi; Lior Ziserman; Dganit Danino; Assaf Friedler; Daniel Harries
Crowding alone cannot account for cosolute effect on amyloid aggregation.
PloS one 2011;6(1):e15608.
2011: Aviad Levin; Hadar Benyamini; Zvi Hayouka; Assaf Friedler; Abraham Loyter
Peptides that bind the HIV-1 integrase and modulate its enzymatic activity--kinetic studies and mode of action.
The FEBS journal 2011;278(2):316-30.
2010: Zvi Hayouka; Mattan Hurevich; Aviad Levin; Hadar Benyamini; Anat Iosub; Michal Maes; Deborah E Shalev; Abraham Loyter; Chaim Gilon; Assaf Friedler
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein.
Bioorganic & medicinal chemistry 2010;18(23):8388-95.
2010: Liron Levy-Beladev; Lilia Levdansky; Elena Gaberman; Assaf Friedler; Raphael Gorodetsky
A family of cell-adhering peptides homologous to fibrinogen C-termini.
Biochemical and biophysical research communications 2010;401(1):124-30.
2010: Aviad Levin; Assaf Friedler; Zvi Hayouka; Abraham Loyter
Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells.
Nucleus (Austin, Tex.) 2010;1(5):422-31.
2010: Aviad Levin; Zvi Hayouka; Markus Helfer; Ruth Brack-Werner; Assaf Friedler; Abraham Loyter
Stimulation of the HIV-1 integrase enzymatic activity and cDNA integration by a peptide derived from the integrase protein.
Biopolymers 2010;93(8):740-51.
2010: tali Reingewertz; Deborah E Shalev; Assaf Friedler
Structural disorder in the HIV-1 Vif protein and interaction-dependent gain of structure.
Protein and peptide letters 2010;17(8):988-98.
2010: Shai Garty; Nadav Kimelman-Bleich; Zvi Hayouka; Daniel Cohn; Assaf Friedler; Gadi Pelled; Dan Gazit
Peptide-modified "smart" hydrogels and genetically engineered stem cells for skeletal tissue engineering.
Biomacromolecules 2010;11(6):1516-26.
2010: Hadar Benyamini; Assaf Friedler
Using peptides to study protein-protein interactions.
Future medicinal chemistry 2010;2(6):989-1003.
2010: Aviad Levin; Zvi Hayouka; Assaf Friedler; Abraham Loyter
Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells.
Virus genes 2010;40(3):341-6.
2010: Aviad Levin; Zvi Hayouka; Assaf Friedler; Ruth Brack-Werner; David J Volsky; Abraham Loyter
A novel role for the viral Rev protein in promoting resistance to superinfection by human immunodeficiency virus type 1.
The Journal of general virology 2010;91(Pt 6):1503-13.
2010: Zvi Hayouka; Aviad Levin; Michal Maes; Eran Hadas; Deborah E Shalev; David J Volsky; Abraham Loyter; Assaf Friedler
Mechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370.
Biochemical and biophysical research communications 2010;394(2):260-5.
2010: Denise Ronen; Masha M Rosenberg; Deborah E Shalev; Michael Rosenberg; Shahar Rotem; Assaf Friedler; Shoshana Ravid
The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly.
The Journal of biological chemistry 2010;285(10):7079-86.
2010: Aviad Levin; Assaf Friedler; Zvi Hayouka; Abraham Loyter
Nucleocytoplasmic shuttling of HIV-1 integrase is controlled by the viral Rev protein.
Nucleus (Austin, Tex.) 2010;1(2):190-201.
2010: Aviad Levin; Zvi Hayouka; Assaf Friedler; Abraham Loyter
Specific eradication of HIV-1 from infected cultured cells.
AIDS research and therapy 2010;7():31.
2010: Aviad Levin; Zvi Hayouka; Assaf Friedler; Abraham Loyter
Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells.
Virology journal 2010;7():177.
2010: Aviad Levin; Joseph Rosenbluh; Zvi Hayouka; Assaf Friedler; Abraham Loyter
Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins.
Molecular medicine (Cambridge, Mass.) 2010;16(1-2):34-44.
2009: Aviad Levin; Zvi Hayouka; Ruth Brack-Werner; David J Volsky; Assaf Friedler; Abraham Loyter
Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration.
Protein engineering, design & selection : PEDS 2009;22(12):753-63.
2009: Michal Maes; Aviad Levin; Zvi Hayouka; Deborah E Shalev; Abraham Loyter; Assaf Friedler
Peptide inhibitors of HIV-1 integrase: from mechanistic studies to improved lead compounds.
Bioorganic & medicinal chemistry 2009;17(22):7635-42.
2009: Hadar Benyamini; Hadas Leonov; Shahar Rotem; Chen Katz; Isaiah T Arkin; Assaf Friedler
A model for the interaction between NF-kappa-B and ASPP2 suggests an I-kappa-B-like binding mechanism.
Proteins 2009;77(3):602-11.
2009: tali Reingewertz; Hadar Benyamini; Mario Lebendiker; Deborah E Shalev; Assaf Friedler
The C-terminal domain of the HIV-1 Vif protein is natively unfolded in its unbound state.
Protein engineering, design & selection : PEDS 2009;22(5):281-7.
2009: Nir Qvit; Ada Hatzubai; Deborah E Shalev; Assaf Friedler; Yinon Ben-Neriah; Chaim Gilon
Design and synthesis of backbone cyclic phosphorylated peptides: The IkappaB model.
Biopolymers 2009;91(2):157-68.
2009: Aviad Levin; Zvi Hayouka; Markus Helfer; Ruth Brack-Werner; Assaf Friedler; Abraham Loyter
Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration.
PloS one 2009;4(1):e4155.
2008: Chen Katz; Hadar Benyamini; Shahar Rotem; Mario Lebendiker; tsafi danieli; Anat Iosub; Hadar Refaely; Monica Dines; Vered Bronner; Tsafrir Bravman; Deborah E Shalev; Stefan Rüdiger; Assaf Friedler
Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12277-82.
2008: Shahar Rotem; Chen Katz; Hadar Benyamini; Mario Lebendiker; Dmitry B Veprintsev; Stefan Rüdiger; tsafi danieli; Assaf Friedler
The structure and interactions of the proline-rich domain of ASPP2.
The Journal of biological chemistry 2008;283(27):18990-9.
2008: Ayelet Armon-Omer; Aviad Levin; Zvi Hayouka; Karin Butz; Felix Hoppe-Seyler; Shoshana Loya; Amnon Hizi; Assaf Friedler; Abraham Loyter
Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library.
Journal of molecular biology 2008;376(4):971-82.
2008: Zvi Hayouka; Joseph Rosenbluh; Aviad Levin; Michal Maes; Abraham Loyter; Assaf Friedler
Peptides derived from HIV-1 Rev inhibit HIV-1 integrase in a shiftide mechanism.
Biopolymers 2008;90(4):481-7.
2008: Ronen Gabizon; Michal Mor; Masha M Rosenberg; Lena Britan; Zvi Hayouka; Moshe Kotler; Deborah E Shalev; Assaf Friedler
Using peptides to study the interaction between the p53 tetramerization domain and HIV-1 Tat.
Biopolymers 2008;90(2):105-16.
2007: Gideon Coster; Zvi Hayouka; Liron Argaman; Carmit Strauss; Assaf Friedler; Michael Brandeis; Michal Goldberg
The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.
The Journal of biological chemistry 2007;282(44):32053-64.
2007: Shahar Rotem; C Katz; Assaf Friedler
Insights into the structure and protein-protein interactions of the pro-apoptotic protein ASPP2.
Biochemical Society transactions 2007;35(Pt 5):966-9.
2007: Noa Kirshenboim; Zvi Hayouka; Assaf Friedler; Amnon Hizi
Expression and characterization of a novel reverse transcriptase of the LTR retrotransposon Tf1.
Virology 2007;366(2):263-76.
2007: Joseph Rosenbluh; Zvi Hayouka; Shoshana Loya; Aviad Levin; Ayelet Armon-Omer; Elena Britan; Amnon Hizi; Moshe Kotler; Assaf Friedler; Abraham Loyter
Interaction between HIV-1 Rev and integrase proteins: a basis for the development of anti-HIV peptides.
The Journal of biological chemistry 2007;282(21):15743-53.
2007: Zvi Hayouka; Joseph Rosenbluh; Aviad Levin; Shoshana Loya; Mario Lebendiker; Dmitry B Veprintsev; Moshe Kotler; Amnon Hizi; Abraham Loyter; Assaf Friedler
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8316-21.
2006: Sophia Diamant; Erez Podoly; Assaf Friedler; Hagai Ligumsky; Oded Livnah; Hermona Soreq
Butyrylcholinesterase attenuates amyloid fibril formation in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8628-33.
2005: Assaf Friedler; Dmitry B Veprintsev; Stefan M V Freund; Karoly I von Glos; Alan Fersht
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation.
Structure (London, England : 1993) 2005;13(4):629-36.
2005: Assaf Friedler; Dmitry B Veprintsev; Trevor Rutherford; Karoly I von Glos; Alan Fersht
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.
The Journal of biological chemistry 2005;280(9):8051-9.
2004: Caroline M S Ekblad; Assaf Friedler; Dmitry B Veprintsev; Richard L Weinberg; Laura S Itzhaki
Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis.
Protein science : a publication of the Protein Society 2004;13(3):617-25.
2004: Oliver Schon; Assaf Friedler; Stefan M V Freund; Alan Fersht
Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes.
Journal of molecular biology 2004;336(1):197-202.
2004: Assaf Friedler; Brian S DeDecker; Stefan M V Freund; Caroline Blair; Stefan Rüdiger; Alan Fersht
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".
Journal of molecular biology 2004;336(1):187-96.
2003: Markus A Seeliger; Sadie E Breward; Assaf Friedler; Oliver Schon; Laura S Itzhaki
Cooperative organization in a macromolecular complex.
Nature structural biology 2003;10(9):718-24.
2003: Assaf Friedler; Dmitry B Veprintsev; Lars O Emrén; Alan Fersht
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules.
The Journal of biological chemistry 2003;278(26):24108-12.
2002: Oliver Schon; Assaf Friedler; Mark Bycroft; Stefan M V Freund; Alan Fersht
Molecular mechanism of the interaction between MDM2 and p53.
Journal of molecular biology 2002;323(3):491-501.
2002: Mark Allen; Assaf Friedler; Oliver Schon; Mark Bycroft
The structure of an FF domain from human HYPA/FBP11.
Journal of molecular biology 2002;323(3):411-6.
2002: Lea Baraz; Marina Hutoran; Immanuel Blumenzweig; Mark Katzenellenbogen; Assaf Friedler; Chaim Gilon; Michael Steinitz; Moshe Kotler
Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region.
The Journal of general virology 2002;83(Pt 9):2225-30.
2002: Lars O Emrén; Assaf Friedler; Stefan M V Freund; Stefan Rudiger; Alan Fersht
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10305-9.
2002: Immanuel Blumenzweig; Lea Baraz; Assaf Friedler; Helena Danielson; Chaim Gilon; Michael Steinitz; Moshe Kotler
HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases.
Biochemical and biophysical research communications 2002;292(4):832-40.
2002: Elana Hariton-Gazal; Dorit Friedler; Assaf Friedler; Nehama Zakai; Chaim Gilon; Abraham Loyter
Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence.
Biochimica et biophysica acta 2002;1594(2):234-42.
2002: Assaf Friedler; Lars O Emrén; Dmitry B Veprintsev; Stefan M V Freund; Thomas M Rippin; Penka V Nikolova; Mark R Proctor; Stefan Rüdiger; Alan Fersht
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):937-42.
2001: Joost Schymkowitz; Frederic Rousseau; Hannah R Wilkinson; Assaf Friedler; Laura S Itzhaki
Observation of signal transduction in three-dimensional domain swapping.
Nature structural biology 2001;8(10):888-92.
2000: Assaf Friedler; Dorit Friedler; Nathan W Luedtke; Yitzhak Tor; Abraham Loyter; Chaim Gilon
Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif.
The Journal of biological chemistry 2000;275(31):23783-9.
1999: Assaf Friedler; Nehama Zakai; Osnat Karni; Dorit Friedler; Chaim Gilon; Abraham Loyter
Identification of a nuclear transport inhibitory signal (NTIS) in the basic domain of HIV-1 Vif protein.
Journal of molecular biology 1999;289(3):431-7.
1999: Assaf Friedler; Immanuel Blumenzweig; Lea Baraz; Michael Steinitz; Moshe Kotler; Chaim Gilon
Peptides derived from HIV-1 Vif: a non-substrate based novel type of HIV-1 protease inhibitors.
Journal of molecular biology 1999;287(1):93-101.
1998: Lea Baraz; Assaf Friedler; Immanuel Blumenzweig; O Nussinuv; N Chen; Michael Steinitz; Chaim Gilon; Moshe Kotler
Human immunodeficiency virus type 1 Vif-derived peptides inhibit the viral protease and arrest virus production.
FEBS letters 1998;441(3):419-26.
1998: Osnat Karni; Assaf Friedler; Nehama Zakai; Chaim Gilon; Abraham Loyter
A peptide derived from the N-terminal region of HIV-1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr.
FEBS letters 1998;429(3):421-5.
1998: Assaf Friedler; Nehama Zakai; Osnat Karni; Y C Broder; Lea Baraz; Moshe Kotler; Abraham Loyter; Chaim Gilon
Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells.
Biochemistry 1998;37(16):5616-22.
1997: Y C Broder; Ariel Stanhill; Nehama Zakai; Assaf Friedler; Chaim Gilon; Abraham Loyter
Translocation of NLS-BSA conjugates into nuclei of permeabilized mammalian cells can be supported by protoplast extract. An experimental system for studying plant cytosolic factors involved in nuclear import.
FEBS letters 1997;412(3):535-9.