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Scott Friedman

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Moira Hilscher; Virginia Hernandez-Gea; Scott L Friedman
Autophagy and mesenchymal cell fibrogenesis.
Scott L Friedman
Focus.
Lars P Bechmann; Paul D Berk; M Isabel Fiel; Loranne Agius; Fengxia Ge; Rebekka Anna Hannivoort; Kei Yiu Hui; Junichi Ishida; Peri Kocabayoglu; Ursula E Lang; Young-Min Lee; Derek LeRoith; Xiaosong Li; Ursula Muñoz; Ryozo Nagai; Gillian L Patman; Helen L Reeves; Gary J Schwartz; Toru Suzuki; Despina Televantou; Diana Vetter; Shoshana Yakar; Weijia Zhang; Scott L Friedman
Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.

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All Publications

2013: Moira Hilscher; Virginia Hernandez-Gea; Scott L Friedman
Autophagy and mesenchymal cell fibrogenesis.
Biochimica et biophysica acta 2013;1832(7):972-8.
2013: Scott L Friedman
Focus.
Journal of hepatology 2013;58(5):845-6.
2013: Lars P Bechmann; Paul D Berk; M Isabel Fiel; Loranne Agius; Fengxia Ge; Rebekka Anna Hannivoort; Kei Yiu Hui; Junichi Ishida; Peri Kocabayoglu; Ursula E Lang; Young-Min Lee; Derek LeRoith; Xiaosong Li; Ursula Muñoz; Ryozo Nagai; Gillian L Patman; Helen L Reeves; Gary J Schwartz; Toru Suzuki; Despina Televantou; Diana Vetter; Shoshana Yakar; Weijia Zhang; Scott L Friedman
Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.
Journal of hepatology 2013;58(5):1000-6.
2013: Lars P Bechmann; Anja Beilfuss; Frieder Berr; Jan Best; Scott L Friedman; Andreas Geier; Guido Gerken; Rebekka Anna Hannivoort; Alpaslan Kilicarslan; Peri Kocabayoglu; Christian Rust; Martin Schlattjan; Johannes Schmitt; Jan-Peter Sowa; Svenja Sydor; Oliver Tschopp; Ali Canbay
Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2013;57(4):1394-406.
2013: Virginia Hernandez-Gea; Scott L Friedman; Sara Toffanin; Josep M Llovet
Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma.
Gastroenterology 2013;144(3):512-27.
2013: Scott L Friedman
Focus.
Journal of hepatology 2013;58(3):407-8.
2013: Scott L Friedman
Liver fibrosis in 2012: Convergent pathways that cause hepatic fibrosis in NASH.
Nature reviews. Gastroenterology & hepatology 2013;10(2):71-2.
2013: Zahra Ghiassi-Nejad; Virginia Hernandez-Gea; Allison Kwong; Ursula E Lang; Christopher Woodrell; Katja Dumic; Scott L Friedman
Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury.
Hepatology (Baltimore, Md.) 2013;57(2):786-96.
2013: Scott L Friedman; Dean Sheppard; Jeremy S Duffield; Shelia Violette
Therapy for fibrotic diseases: nearing the starting line.
Science translational medicine 2013;5(167):167sr1.
2013: Eva M Garrido-Martín; Ursula E Lang; Laura Novensà; Mercé Roquè; Toru Suzuki; Mirko Tarocchi; Francisco J Blanco; Luisa M Botella; Scott L Friedman; Carmelo Bernabéu
Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene.
Circulation research 2013;112(1):113-27.
2013: Peri Kocabayoglu; Scott L Friedman
Cellular basis of hepatic fibrosis and its role in inflammation and cancer.
Frontiers in bioscience (Scholar edition) 2013;5():217-30.
2013: Scott L Friedman
Focus.
Journal of hepatology 2013;58(1):1-2.
2013: Juan E Puche; Hal F Yee; Costica Aloman; M Isabel Fiel; Jingjing Jiao; Thomas Kraus; Tingfang Lee; Youngmin A Lee; Ursula Muñoz; Scott L Friedman
A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice.
Hepatology (Baltimore, Md.) 2013;57(1):339-50.
2013: Feng Hong; Hsini Chou; M Isabel Fiel; Scott L Friedman
Antifibrotic activity of sorafenib in experimental hepatic fibrosis: refinement of inhibitory targets, dosing, and window of efficacy in vivo.
Digestive diseases and sciences 2013;58(1):257-64.
2012: Scott L Friedman
Focus.
Journal of hepatology 2012;57(5):935-6.
2012: Diana Vetter; Augusto Villanueva; Michal Cohen-Naftaly; Rebekka Anna Hannivoort; Peri Kocabayoglu; Youngmin A Lee; Josep M Llovet; Goutham Narla; Swan N Thung; Scott L Friedman
Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing.
Hepatology (Baltimore, Md.) 2012;56(4):1361-70.
2012: Anja Lachenmayer; Clara Alsinet-Armengol; Jordi Barretina; Jordi Bruix; Laia Cabellos; Scott L Friedman; Yujin Hoshida; Vincenzo Mazzaferro; Beatriz Minguez; Philippa Newell; Radoslav Savic; Myron Schwartz; Swan Thung; Sara Toffanin; Hung-Wen Tsai; Augusto Villanueva; Stephen C Ward; Josep M Llovet
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(18):4997-5007.
2012: Scott L Friedman
Protect thee from the sins of thy fathers?
Nature medicine 2012;18(9):1331-2.
2012: Úrsula Muñoz; Michal Cohen-Naftaly; Rebekka Hannivoort; Ursula E Lang; Juan E Puche; Scott L Friedman
Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1.
Molecular cancer research : MCR 2012;10(9):1216-27.
2012: Scott L Friedman
Focus.
Journal of hepatology 2012;57(3):481-3.
2012: David Y Zhang; Scott L Friedman
Fibrosis-dependent mechanisms of hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2012;56(2):769-75.
2012: Scott L Friedman
Focus. Metchnikoff, macrophages and the metabolic syndrome.
Journal of hepatology 2012;57(1):1-2.
2012: Youngchul Kim; Weijia Zhang; Gregory Khitrov; Efsevia Albanis; Hsin I Chou; M Isabel Fiel; Scott L Friedman
Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(6):1008-17.
2012: Anja Lachenmayer; Clara Alsinet-Armengol; Laia Cabellos; Scott L Friedman; Yujin Hoshida; Beatriz Minguez; Swan Thung; Sara Toffanin; Hung-Wen Tsai; Augusto Villanueva; Stephen C Ward; Josep M Llovet
Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib.
Journal of hepatology 2012;56(6):1343-50.
2012: Virginia Hernández-Gea; Scott L Friedman
Autophagy fuels tissue fibrogenesis.
Autophagy 2012;8(5):849-50.
2012: Scott L Friedman
A silent partner no longer – sinusoidal endothelial cells in liver homeostasis and disease.
Journal of hepatology 2012;56(5):1001-2.
2012: Virginia Hernández-Gea; Raphael Rozenfeld; Zhenyu Yue; Mark J Czaja; M Isabel Fiel; Zahra Ghiassi-Nejad; Ronald Gordon; Scott L Friedman
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.
Gastroenterology 2012;142(4):938-46.
2012: Lars P Bechmann; Elisabetta Bugianesi; Alastair D Burt; Emma Buzzigoli; Demetrio Ciociaro; Christopher P Day; Isabel Fiel; Scott L Friedman; Amalia Gastaldelli; Rebekka A Hannivoort; Kei Y Hui; Ursula E Lee; Young-Min Lee; Andrea Mari; Luca Miele; Ursula Muñoz; Laura Pascoe; Gillian L Patman; Diana Vetter; Mark Walker; Loranne Agius; Helen L Reeves
Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.) 2012;55(4):1083-93.
2012: Scott L Friedman
Focus. An emerging conceptual scaffold for NASH.
Journal of hepatology 2012;56(3):511-2.
2012: Yedidya Saiman; Scott L Friedman
The role of chemokines in acute liver injury.
Frontiers in physiology 2012;3():213.
2012: Rebekka A Hannivoort; Virginia Hernandez-Gea; Scott L Friedman
Genomics and proteomics in liver fibrosis and cirrhosis.
Fibrogenesis & tissue repair 2012;5(1):1.
2011: Andrew J Paris; Zohar Snapir; John J Sninsky; Cindy D Christopherson; Zahra Ghiassi-Nejad; Chaim Kahana; Peri Kocabayoglu; Shirley Y Kwok; Ursula E Lee; Josep M Llovet; Scott L Friedman
A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis.
Hepatology (Baltimore, Md.) 2011;54(6):2198-207.
2011: Beatriz Mínguez; Sasan Roayaie; Radoslav Savic; Myron Schwartz; Daniela Sia; Swan Thung; Sara Toffanin; Augusto Villanueva; Craig April; Jordi Bruix; Laia Cabellos; Jian-Bing Fan; Scott L Friedman; Yujin Hoshida; Anja Lachenmayer; John Mandeli; Vincenzo Mazzaferro; Josep M Llovet
Gene-expression signature of vascular invasion in hepatocellular carcinoma.
Journal of hepatology 2011;55(6):1325-31.
2011: Michal Cohen-Naftaly; Scott L Friedman
Current status of novel antifibrotic therapies in patients with chronic liver disease.
Therapeutic advances in gastroenterology 2011;4(6):391-417.
2011: Scott L Friedman
Nature, natural and NAFLD.
Journal of hepatology 2011;55(5):953-4.
2011: Scott L Friedman
Focus.
Journal of hepatology 2011;55(3):503-4.
2011: Mirko Tarocchi; Diana Vetter; Augusto Villanueva; Rebekka Anna Hannivoort; Yujin Hoshida; Ursula E Lee; Josep M Llovet; Goutham Narla; Moshe Oren; Scott L Friedman
Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.
Hepatology (Baltimore, Md.) 2011;54(2):522-31.
2011: Scott L Friedman
Focus.
Journal of hepatology 2011;55(1):1-2.
2011: Sara Toffanin; Yujin Hoshida; Anja Lachenmayer; Augusto Villanueva; Laia Cabellos; Beatriz Minguez; Radoslav Savic; Stephen C Ward; Swan Thung; Derek Chiang; Clara Alsinet-Armengol; Victoria Tovar; Sasan Roayaie; Myron Schwartz; Jordi Bruix; Samuel Waxman; Scott L Friedman; Todd Golub; Vincenzo Mazzaferro; Josep M Llovet
MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a.
Gastroenterology 2011;140(5):1618-28.e16.
2011: Costica Aloman; Scott L Friedman; Miriam Merad
Dendritic cells in alcoholic liver injury and fibrosis.
Alcoholism, clinical and experimental research 2011;35(5):776-81.
2011: Scott L Friedman
Focus.
Journal of hepatology 2011;54(5):841-3.
2011: Virginia Hernandez-Gea; Scott L Friedman
Platelets arrive at the scene of fibrosis……studies.
Journal of hepatology 2011;54(5):1063-5.
2011: Ursula E Lee; Scott L Friedman
Mechanisms of hepatic fibrogenesis.
Best practice & research. Clinical gastroenterology 2011;25(2):195-206.
2011: Li-Jun Peng; Jin-Sheng Guo; Zhe Zhang; Hong Shi; Jian Wang; Scott L Friedman; John J Sninsky; Ji-Yao Wang
[Polymorphism of ornithine decarboxylase antizyme inhibitor 1 gene is associated with liver cirrhosis in Chinese hepatitis B patients].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2011;19(3):169-73.
2011: Brian D Radbill; Ritu Gupta; Maria Celeste M Ramirez; Analisa Difeo; John A Martignetti; Carlos E Alvarez; Scott L Friedman; Goutham Narla; Raluca Vrabie; Robert Bowles; Yedidya Saiman; Meena B Bansal
Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression.
Digestive diseases and sciences 2011;56(2):406-16.
2011: Virginia Hernandez-Gea; Scott L Friedman
Pathogenesis of liver fibrosis.
Annual review of pathology 2011;6():425-56.
2010: Scott L Friedman
Evolving challenges in hepatic fibrosis.
Nature reviews. Gastroenterology & hepatology 2010;7(8):425-36.
2010: Xiao Zhao; Christopher Monson; Chuan Gao; Valerie Gouon-Evans; Nobuyuki Matsumoto; Kirsten C Sadler; Scott L Friedman
Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells.
Developmental biology 2010;344(1):79-93.
2010: Ting Fang Lee; Ki M Mak; Ori Rackovsky; Yun-Lian Lin; Allison J Kwong; Johnny C Loke; Scott L Friedman
Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation-related protein (ADRP).
Journal of cellular physiology 2010;223(3):648-57.
2010: Ursula E Lee; Zahra Ghiassi-Nejad; Andrew J Paris; Steven Yea; Goutham Narla; Martin Walsh; Scott L Friedman
Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.
FEBS letters 2010;584(5):1006-10.
2010: Jinsheng Guo; Feng Hong; Johnny Loke; Steven Yea; Chooi Ling Lim; Ursula Lee; Derek A Mann; Martin J Walsh; John J Sninsky; Scott L Friedman
A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells.
The Journal of biological chemistry 2010;285(8):5428-37.
2010: Sara Toffanin; Scott L Friedman; Josep M Llovet
Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link.
Cancer cell 2010;17(2):115-7.
2010: Jinsheng Guo; Scott L Friedman
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis.
Fibrogenesis & tissue repair 2010;3():21.
2010: Eva M Garrido-Martin; Francisco J Blanco; Africa Fernandez-L; Carmen Langa; Calvin P H Vary; Ursula E Lee; Scott L Friedman; Luisa M Botella; Carmelo Bernabeu
Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1.
BMC molecular biology 2010;11():51.
2009: Hui-Hui Tan; M Isabel Fiel; Qinghua Sun; Jinsheng Guo; Ronald E Gordon; Lung Chi Chen; Scott L Friedman; Joseph A Odin; Jorge Allina
Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease.
Journal of immunotoxicology 2009;6(4):266-75.
2009: Pippa Newell; Sara Toffanin; Augusto Villanueva; Derek Chiang; Beatriz Minguez; Laia Cabellos; Radoslav Savic; Yujin Hoshida; Kiat Hon Lim; Pedro Melgar-Lesmes; Steven Yea; Judit Peix; Kemal Deniz; M Isabel Fiel; Swan Thung; Clara Alsinet-Armengol; Victoria Tovar; Vincenzo Mazzaferro; Jordi Bruix; Sasan Roayaie; Myron Schwartz; Scott L Friedman; Josep M Llovet
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.
Journal of hepatology 2009;51(4):725-33.
2009: Yujin Hoshida; Sebastian M B Nijman; Masahiro Kobayashi; Jennifer A Chan; Jean-Philippe Brunet; Derek Chiang; Augusto Villanueva; Philippa Newell; Kenji Ikeda; Masaji Hashimoto; Goro Watanabe; Stacey Gabriel; Scott L Friedman; Hiromitsu Kumada; Josep M Llovet; Todd R Golub
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.
Cancer research 2009;69(18):7385-92.
2009: Jingjing Jiao; Scott L Friedman; Costica Aloman
Hepatic fibrosis.
Current opinion in gastroenterology 2009;25(3):223-9.
2009: Luisa M Botella; Francisco Sanz-Rodriguez; Yusuke Komi; Africa Fernandez-L; Elisa Varela; Eva M Garrido-Martin; Goutham Narla; Scott L Friedman; Soichi Kojima
TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction.
The Biochemical journal 2009;419(2):485-95.
2009: Jaya Sangodkar; Jiayan Shi; Analisa Difeo; Rachel Schwartz; Romina Bromberg; Aisha Choudhri; Kim McClinch; Raheleh Hatami; Elias Scheer; Sigal Kremer-Tal; John A Martignetti; Alex Hui; W K Leung; Scott L Friedman; Goutham Narla
Functional role of the KLF6 tumour suppressor gene in gastric cancer.
European journal of cancer (Oxford, England : 1990) 2009;45(4):666-76.
2009: Jinsheng Guo; Johnny Loke; Feng Zheng; Feng Hong; Steven Yea; Masayuki Fukata; Mirko Tarocchi; Olivia T Abar; Hongjin Huang; John J Sninsky; Scott L Friedman
Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.
Hepatology (Baltimore, Md.) 2009;49(3):960-8.
2008: Scott L Friedman
Hepatic fibrosis -- overview.
Toxicology 2008;254(3):120-9.
2008: Yujin Hoshida; Augusto Villanueva; Masahiro Kobayashi; Judit Peix; Derek Chiang; Amy Camargo; Supriya Gupta; Jamie Moore; Matthew J Wrobel; Jim Lerner; Michael Reich; Jennifer A Chan; Jonathan N Glickman; Kenji Ikeda; Masaji Hashimoto; Goro Watanabe; Maria G Daidone; Sasan Roayaie; Myron Schwartz; Swan Thung; Helga B Salvesen; Stacey Gabriel; Vincenzo Mazzaferro; Jordi Bruix; Scott L Friedman; Hiromitsu Kumada; Josep M Llovet; Todd R Golub
Gene expression in fixed tissues and outcome in hepatocellular carcinoma.
The New England journal of medicine 2008;359(19):1995-2004.
2008: Scott L Friedman
Preface. Hepatic fibrosis: pathogenesis, diagnosis, and emerging therapies.
Clinics in liver disease 2008;12(4):xiii-xiv.
2008: Nidal Muhanna; Sarit Doron; Ori Wald; Amjad Horani; Ahmed Eid; Orit Pappo; Scott L Friedman; Rifaat Safadi
Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis.
Hepatology (Baltimore, Md.) 2008;48(3):963-77.
2008: Derek Chiang; Augusto Villanueva; Yujin Hoshida; Judit Peix; Philippa Newell; Beatriz Minguez; Amanda C LeBlanc; Diana J Donovan; Swan N Thung; Manel Solé; Victoria Tovar; Clara Alsinet-Armengol; Alex H Ramos; Jordi Barretina; Sasan Roayaie; Myron Schwartz; Samuel Waxman; Jordi Bruix; Vincenzo Mazzaferro; Azra H Ligon; Vesna Najfeld; Scott L Friedman; William R Sellers; Matthew Meyerson; Josep M Llovet
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.
Cancer research 2008;68(16):6779-88.
2008: Goutham Narla; Analisa Difeo; Yolanda Fernandez; Saravana M Dhanasekaran; Fei Huang; Jaya Sangodkar; Eldad Hod; Devin Leake; Scott L Friedman; Simon J Hall; Arul M Chinnaiyan; William L Gerald; Mark A Rubin; John A Martignetti
KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
The Journal of clinical investigation 2008;118(8):2711-21.
2008: Scott L Friedman
Mechanisms of hepatic fibrogenesis.
Gastroenterology 2008;134(6):1655-69.
2008: Steven Yea; Goutham Narla; Xiao Zhao; Rakhi Garg; Sigal Tal-Kremer; Eldad Hod; Augusto Villanueva; Johnny Loke; Mirko Tarocchi; Kunihara Akita; Senji Shirasawa; Takehiko Sasazuki; John A Martignetti; Josep M Llovet; Scott L Friedman
Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.
Gastroenterology 2008;134(5):1521-31.
2008: Philippa Newell; Augusto Villanueva; Scott L Friedman; Kazuhiko Koike; Josep M Llovet
Experimental models of hepatocellular carcinoma.
Journal of hepatology 2008;48(5):858-79.
2008: Abd Al-Roof Higazi; M El-Haj; Alaa Melhem; Amjad Horani; Orit Pappo; Carlos E Alvarez; Nidal Muhanna; Scott L Friedman; Rifaat Safadi
Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis.
Clinical and experimental immunology 2008;152(1):163-73.
2008: Itay Bentov; Goutham Narla; Hagit Schayek; Kuhihara Akita; Stephen R Plymate; Derek LeRoith; Scott L Friedman; Haim Werner
Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.
Endocrinology 2008;149(4):1890-7.
2008: Scott L Friedman; Natalia Nieto
Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors.
Cell metabolism 2008;7(3):187-8.
2008: Scott L Friedman
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.
Physiological reviews 2008;88(1):125-72.
2007: Scott L Friedman
A deer in the headlights: BAMBI meets liver fibrosis.
Nature medicine 2007;13(11):1281-2.
2007: Jinsheng Guo; Scott L Friedman
Hepatic fibrogenesis.
Seminars in liver disease 2007;27(4):413-26.
2007: Miriam S Teixeira; Olga Camacho-Vanegas; Yolanda Fernandez; Goutham Narla; Analisa Difeo; Bryant Lee; Tamara Kalir; Scott L Friedman; Nicolas F Schlecht; Eric M Genden; Mark L Urken; Margaret Brandwein-Gensler; John A Martignetti
KLF6 allelic loss is associated with tumor recurrence and markedly decreased survival in head and neck squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2007;121(9):1976-83.
2007: Scott L Friedman
Liver fibrosis: from mechanisms to treatment.
Gastroentérologie clinique et biologique 2007;31(10):812-4.
2007: Olga Camacho-Vanegas; Goutham Narla; Miriam S Teixeira; Analisa Difeo; Anjan Misra; Gobind Singh; Andrew M Chan; Scott L Friedman; Burt Feuerstein; John A Martignetti
Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.
International journal of cancer. Journal international du cancer 2007;121(6):1390-5.
2007: Goutham Narla; Sigal Kremer-Tal; N Matsumoto; X Zhao; Shen Yao; K Kelley; M Tarocchi; Scott L Friedman
In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma.
Oncogene 2007;26(30):4428-34.
2007: Scott L Friedman
Reversibility of hepatic fibrosis and cirrhosis--is it all hype?
Nature clinical practice. Gastroenterology & hepatology 2007;4(5):236-7.
2007: Sigal Kremer-Tal; Goutham Narla; Ying-bei Chen; Eldad Hod; Analisa Difeo; Steven Yea; Ju Seog Lee; Myron Schwartz; Swan N Thung; Isabel M Fiel; Michaela S Banck; Eran Zimran; Snorri S Thorgeirsson; Vincenzo Mazzaferro; Jordi Bruix; John A Martignetti; Josep M Llovet; Scott L Friedman
Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation.
Journal of hepatology 2007;46(4):645-54.
2007: Augusto Villanueva; Philippa Newell; Derek Chiang; Scott L Friedman; Josep M Llovet
Genomics and signaling pathways in hepatocellular carcinoma.
Seminars in liver disease 2007;27(1):55-76.
2007: Amjad Horani; Nidal Muhanna; Orit Pappo; Alaa Melhem; Carlos E Alvarez; Sarit Doron; Wehbi Wehbi; Karussis Dimitrios; Scott L Friedman; Rifaat Safadi
Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(2):G628-38.
2007: Scott L Friedman; Don C Rockey; D Montgomery Bissell
Hepatic fibrosis 2006: report of the Third AASLD Single Topic Conference.
Hepatology (Baltimore, Md.) 2007;45(1):242-9.
2007: Scott L Friedman
Reefer madness? Assessing the effects of cannabinoids with a less jaundiced eye.
Journal of hepatology 2007;46(1):180-2.
2006: Michaela S Banck; Simon W Beaven; Goutham Narla; Martin J Walsh; Scott L Friedman; Andreas S Beutler
KLF6 degradation after apoptotic DNA damage.
FEBS letters 2006;580(30):6981-6.
2006: Josep M Llovet; Ying-bei Chen; Elisa Wurmbach; Sasan Roayaie; M Isabel Fiel; Myron Schwartz; Swan N Thung; Gregory Khitrov; Weijia Zhang; Augusto Villanueva; Carlo Battiston; Vincenzo Mazzaferro; Jordi Bruix; Samuel Waxman; Scott L Friedman
A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis.
Gastroenterology 2006;131(6):1758-67.
2006: Eric R Lemmer; Scott L Friedman; Josep M Llovet
Molecular diagnosis of chronic liver disease and hepatocellular carcinoma: the potential of gene expression profiling.
Seminars in liver disease 2006;26(4):373-84.
2006: Scott L Friedman
Transcriptional regulation of stellate cell activation.
Journal of gastroenterology and hepatology 2006;21 Suppl 3():S79-83.
2006: Analisa Difeo; Goutham Narla; Olga Camacho-Vanegas; H Nishio; Stephen L Rose; Richard E Buller; Scott L Friedman; Martin J Walsh; John A Martignetti
E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor.
Oncogene 2006;25(44):6026-31.
2006: Alaa Melhem; Nidal Muhanna; Amal Bishara; Carlos E Alvarez; Yaron Ilan; Taiser Bishara; Amjad Horani; Mithal Nassar; Scott L Friedman; Rifaat Safadi
Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC.
Journal of hepatology 2006;45(1):60-71.
2006: Analisa Difeo; Goutham Narla; Jennifer Hirshfeld; Olga Camacho-Vanegas; Jyothsna Narla; Stephen L Rose; Tamara Kalir; Shen Yao; Alice Levine; Michael J Birrer; Tomas Bonome; Scott L Friedman; Richard E Buller; John A Martignetti
Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(12):3730-9.
2006: Nobuyuki Matsumoto; Atsushi Kubo; Huixian Liu; Kuniharu Akita; Friedrich Laub; Francesco Ramirez; Gordon Keller; Scott L Friedman
Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.
Blood 2006;107(4):1357-65.
2006: Scott L Friedman; Meena B Bansal
Reversal of hepatic fibrosis -- fact or fantasy?
Hepatology (Baltimore, Md.) 2006;43(2 Suppl 1):S82-8.
2006: Alexander Kirschenbaum; Xin-Hua Liu; Shen Yao; Goutham Narla; Scott L Friedman; John A Martignetti; Alice C Levine
Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral versus transition zones.
Carcinogenesis 2006;27(2):216-24.
2005: Dan Li; Steven Yea; Georgia Dolios; John A Martignetti; Goutham Narla; Rong Wang; Martin J Walsh; Scott L Friedman
Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.
Cancer research 2005;65(20):9216-25.
2005: Rifaat Safadi; Carlos E Alvarez; Masayuki Ohta; Jens Brimnes; Thomas A Kraus; Wajahat Z Mehal; Jonathan Bromberg; Lloyd Mayer; Scott L Friedman
Enhanced oral tolerance in transgenic mice with hepatocyte secretion of IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3577-83.
2005: Dan Li; Steven Yea; Side Li; Zhu Chen; Goutham Narla; Michaela S Banck; Jorge Laborda; Song Tan; Jeffrey M Friedman; Scott L Friedman; Martin J Walsh
Krüppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1.
The Journal of biological chemistry 2005;280(29):26941-52.
2005: Goutham Narla; Analisa Difeo; Shen Yao; Asoka Banno; Eldad Hod; Helen L Reeves; Rui F Qiao; Olga Camacho-Vanegas; Alice Levine; Alexander Kirschenbaum; Andrew M Chan; Scott L Friedman; John A Martignetti
Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.
Cancer research 2005;65(13):5761-8.
2005: Meena B Bansal; Kellen Kovalovich; Ritu Gupta; Wei Li; Akansha Agarwal; Brian Radbill; Carlos E Alvarez; Rifaat Safadi; M Isabel Fiel; Scott L Friedman; Rebecca Taub
Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression.
Journal of hepatology 2005;42(4):548-56.
2005: Goutham Narla; Analisa Difeo; Helen L Reeves; Daniel J Schaid; Jennifer Hirshfeld; Eldad Hod; Amanda Katz; William B Isaacs; Scott J Hebbring; Akira Komiya; Shannon K McDonnell; Kathy E Wiley; Steven J Jacobsen; Sarah D Isaacs; Patrick C Walsh; S Lilly Zheng; Bao-Li Chang; Danielle M Friedrichsen; Janet L Stanford; Elaine A Ostrander; Arul M Chinnaiyan; Mark A Rubin; Jianfeng Xu; Stephen N Thibodeau; Scott L Friedman; John A Martignetti
A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.
Cancer research 2005;65(4):1213-22.
2005: Scott L Friedman
Mac the knife? Macrophages- the double-edged sword of hepatic fibrosis.
The Journal of clinical investigation 2005;115(1):29-32.
2005: L Xu; Alex Y Hui; Efsevia Albanis; Michael J P Arthur; Sheila M O'Byrne; William S Blaner; P Mukherjee; Scott L Friedman; Francis J Eng
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.
Gut 2005;54(1):142-51.
2004: Scott L Friedman
Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications.
Nature clinical practice. Gastroenterology & hepatology 2004;1(2):98-105.
2004: Sigal Kremer-Tal; Helen L Reeves; Goutham Narla; Swan N Thung; Myron Schwartz; Analisa Difeo; Amanda Katz; Jordi Bruix; Paulette Bioulac-Sage; John A Martignetti; Scott L Friedman
Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2004;40(5):1047-52.
2004: Rifaat Safadi; Masayuki Ohta; Carlos E Alvarez; M Isabel Fiel; Meena Bansal; Wajahat Z Mehal; Scott L Friedman
Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes.
Gastroenterology 2004;127(3):870-82.
2004: Alex Y Hui; Andrew J Dannenberg; Joseph J Y Sung; Kotha Subbaramaiah; Baoheng Du; Peter Olinga; Scott L Friedman
Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells.
Journal of hepatology 2004;41(2):251-8.
2004: Moran Rubinstein; Gila Idelman; Stephen R Plymate; Goutham Narla; Scott L Friedman; Haim Werner
Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.
Endocrinology 2004;145(8):3769-77.
2004: Alec C Kimmelman; Rui F Qiao; Goutham Narla; Asoka Banno; Nelson Lau; Paula D Bos; Nelson Nuñez Rodriguez; Bertrand C Liang; Abhijit Guha; John A Martignetti; Scott L Friedman; Andrew M Chan
Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.
Oncogene 2004;23(29):5077-83.
2004: Sharon Benzeno; Goutham Narla; Jorge Allina; George Z Cheng; Helen L Reeves; Michaela S Banck; Joseph A Odin; J Alan Diehl; Doris Germain; Scott L Friedman
Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.
Cancer research 2004;64(11):3885-91.
2004: Helen L Reeves; Goutham Narla; Olagunju Ogunbiyi; Asif I Haq; Amanda Katz; Sharon Benzeno; Eldad Hod; Noam Harpaz; Shlomit Goldberg; Sigal Tal-Kremer; Francis J Eng; Michael J P Arthur; John A Martignetti; Scott L Friedman
Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.
Gastroenterology 2004;126(4):1090-103.
2003: Goutham Narla; Scott L Friedman; John A Martignetti
Krüppel cripples prostate cancer: KLF6 progress and prospects.
The American journal of pathology 2003;162(4):1047-52.
2003: Alex Y Hui; Scott L Friedman
Molecular basis of hepatic fibrosis.
Expert reviews in molecular medicine 2003;5(5):1-23.
2003: Efsevia Albanis; Rifaat Safadi; Scott L Friedman
Treatment of hepatic fibrosis: almost there.
Current gastroenterology reports 2003;5(1):48-56.
2003: Scott L Friedman
Liver fibrosis -- from bench to bedside.
Journal of hepatology 2003;38 Suppl 1():S38-53.
2002: Kazuo Ikeda; Li-Hsien Wang; Richard Torres; Hong Zhao; Elvira Olaso; Francis J Eng; Pablo Labrador; Rudiger Klein; David Lovett; George D Yancopoulos; Scott L Friedman; Hsin Chieh Lin
Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.
The Journal of biological chemistry 2002;277(21):19206-12.
2002: Helen L Reeves; Scott L Friedman
Activation of hepatic stellate cells--a key issue in liver fibrosis.
Frontiers in bioscience : a journal and virtual library 2002;7():d808-26.
2002: Natalia Nieto; Scott L Friedman; Arthur I Cederbaum
Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells.
The Journal of biological chemistry 2002;277(12):9853-64.
2002: Elvira Olaso; Juan-Pablo Labrador; LiHsien Wang; Kazuo Ikeda; Francis J Eng; Rudiger Klein; David H Lovett; Hsin Chieh Lin; Scott L Friedman
Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.
The Journal of biological chemistry 2002;277(5):3606-13.
2002: Natalia Nieto; Scott L Friedman; Arthur I Cederbaum
Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species.
Hepatology (Baltimore, Md.) 2002;35(1):62-73.
2001: Goutham Narla; Karen E Heath; Helen L Reeves; Dan Li; Luciana E Giono; Alec C Kimmelman; Marc J Glucksman; J Narla; Francis J Eng; Andrew M Chan; Anna C Ferrari; John A Martignetti; Scott L Friedman
KLF6, a candidate tumor suppressor gene mutated in prostate cancer.
Science (New York, N.Y.) 2001;294(5551):2563-6.
2001: Elvira Olaso; Kazuo Ikeda; Francis J Eng; L Xu; L H Wang; Hsin Chieh Lin; Scott L Friedman
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.
The Journal of clinical investigation 2001;108(9):1369-78.
2001: Francis J Eng; Scott L Friedman
Transcriptional regulation in hepatic stellate cells.
Seminars in liver disease 2001;21(3):385-95.
2001: Efsevia Albanis; Scott L Friedman
Hepatic fibrosis. Pathogenesis and principles of therapy.
Clinics in liver disease 2001;5(2):315-34, v-vi.
2000: Scott L Friedman; J J Maher; D Montgomery Bissell
Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference.
Hepatology (Baltimore, Md.) 2000;32(6):1403-8.
2000: Francis J Eng; Scott L Friedman
Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(1):G7-G11.
2000: Natalia Nieto; Patricia Greenwel; Scott L Friedman; F Zhang; Andrew J Dannenberg; Arthur I Cederbaum
Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2.
The Journal of biological chemistry 2000;275(26):20136-45.
2000: Scott L Friedman
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.
The Journal of biological chemistry 2000;275(4):2247-50.
1999: Natalia Nieto; Scott L Friedman; Patricia Greenwel; Arthur I Cederbaum
CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells.
Hepatology (Baltimore, Md.) 1999;30(4):987-96.
1999: D Li; Scott L Friedman
Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy.
Journal of gastroenterology and hepatology 1999;14(7):618-33.
1999: Scott L Friedman
Stellate cell activation in alcoholic fibrosis--an overview.
Alcoholism, clinical and experimental research 1999;23(5):904-10.
1999: Scott L Friedman
Cytokines and fibrogenesis.
Seminars in liver disease 1999;19(2):129-40.
1998: Elvira Olaso; Scott L Friedman
Molecular regulation of hepatic fibrogenesis.
Journal of hepatology 1998;29(5):836-47.