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Thea Friedman

Research Profile

Disorders

Graft vs Host Disease

Chemicals & Drugs

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T-Lymphocyte Subsets

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Publications

TOP 3
Stacey L Fanning; Stephanie A Berger; Robert Korngold; Johann Stein; Kristin Vazzana; Jenny Zilberberg; Thea M Friedman
Unraveling graft-versus-host disease and graft-versus-leukemia responses using TCR Vβ spectratype analysis in a murine bone marrow transplantation model.
Joanne Filicko-O'Hara; Dolores Grosso; Phyllis R Flomenberg; Thea M Friedman; Janet Brunner; William Drobyski; Andres Ferber; Irina Kakhniashvili; Carolyn Keever-Taylor; Bijoyesh Mookerjee; Julie-An Talano; John I Wagner; Robert Korngold; Neal Flomenberg
Antiviral responses following L-leucyl-L-leucine methyl esther (LLME)-treated lymphocyte infusions: graft-versus-infection without graft-versus-host disease.
Thea M Friedman; Joanne Filicko-O'Hara; Bijoyesh Mookerjee; John L Wagner; Dolores Grosso; Neal Flomenberg; Robert Korngold
T cell repertoire complexity is conserved after LLME treatment of donor lymphocyte infusions.

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All Publications

2013: Stacey L Fanning; Stephanie A Berger; Robert Korngold; Johann Stein; Kristin Vazzana; Jenny Zilberberg; Thea M Friedman
Unraveling graft-versus-host disease and graft-versus-leukemia responses using TCR Vβ spectratype analysis in a murine bone marrow transplantation model.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):447-57.
2009: Joanne Filicko-O'Hara; Dolores Grosso; Phyllis R Flomenberg; Thea M Friedman; Janet Brunner; William Drobyski; Andres Ferber; Irina Kakhniashvili; Carolyn Keever-Taylor; Bijoyesh Mookerjee; Julie-An Talano; John I Wagner; Robert Korngold; Neal Flomenberg
Antiviral responses following L-leucyl-L-leucine methyl esther (LLME)-treated lymphocyte infusions: graft-versus-infection without graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(12):1609-19.
2007: Thea M Friedman; Joanne Filicko-O'Hara; Bijoyesh Mookerjee; John L Wagner; Dolores Grosso; Neal Flomenberg; Robert Korngold
T cell repertoire complexity is conserved after LLME treatment of donor lymphocyte infusions.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(12):1439-47.
2007: Christine G DiRienzo; George F Murphy; Thea M Friedman; Robert Korngold
T-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(3):265-76.
2007: Qian Zhan; Sabina Signoretti; Diana Whitaker-Menezes; Thea M Friedman; Robert Korngold; George F Murphy
Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype.
The Journal of investigative dermatology 2007;127(1):106-15.
2006: Thea M Friedman; Olga Azhipa; Jenny Zilberberg; Yevgeny Tkachuk; Jack W Hsu; Scott D Rowley; Stuart L Goldberg; Robert Korngold; Andrew L Pecora; Robert A Preti
Reconstitution of T cell subset repertoire diversity following multiple antigen-mismatched bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(10):1092-5.
2006: Christine G DiRienzo; George F Murphy; Stephen C Jones; Robert Korngold; Thea M Friedman
T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(8):818-27.
2005: Gabor Varadi; Thea M Friedman; Robert Korngold
A CD4 domain 1 CC' loop peptide analogue enhances engraftment in a murine model of bone marrow transplantation with sublethal conditioning.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005;11(12):979-87.
2004: Swati Choksi; Judith C Kim; Diana Whitaker-Menezes; George F Murphy; Thea M Friedman; Robert Korngold
A CD8 DE loop peptide analog prevents graft-versus-host disease in a multiple minor histocompatibility antigen-mismatched bone marrow transplantation model.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2004;10(10):669-80.
2004: Thea M Friedman; Stephen C Jones; Debbie Statton; George F Murphy; Robert Korngold
Evolution of responding CD4+ and CD8+ T-cell repertoires during the development of graft-versus-host disease directed to minor histocompatibility antigens.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2004;10(4):224-35.
2004: Stephen C Jones; Thea M Friedman; George F Murphy; Robert Korngold
Specific donor Vbeta-associated CD4 T-cell responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2004;10(2):91-105.
2003: Stephen C Jones; George F Murphy; Thea M Friedman; Robert Korngold
Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model.
The Journal of clinical investigation 2003;112(12):1880-6.
2003: Diana Whitaker-Menezes; Stephen C Jones; Thea M Friedman; Robert Korngold; George F Murphy
An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(9):559-70.
2002: Patricia A Taylor; Thea M Friedman; Robert Korngold; Randolph J Noelle; Bruce R Blazar
Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell.
Blood 2002;99(12):4601-9.
2001: Thea M Friedman; Gabor Varadi; D D Hopely; Joanne Filicko; John Wagner; Andres Ferber; Jose Martinez; Janet Brunner; Dolores Grosso; L McGuire; Robert Korngold; Neal Flomenberg
Nonmyeloablative conditioning allows for more rapid T-cell repertoire reconstitution following allogeneic matched unrelated bone marrow transplantation compared to myeloablative approaches.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7(12):656-64.
2001: Thea M Friedman; D Statton; Stephen C Jones; MA Berger; George F Murphy; Robert Korngold
Vbeta spectratype analysis reveals heterogeneity of CD4+ T-cell responses to minor histocompatibility antigens involved in graft-versus-host disease: correlations with epithelial tissue infiltrate.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7(1):2-13.
1998: Thea M Friedman; M Gilbert; C Briggs; Robert Korngold
Repertoire analysis of CD8+ T cell responses to minor histocompatibility antigens involved in graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):41-8.
1997: T Satoh; James M Aramini; Shengwen Li; Thea M Friedman; J Gao; Andrea E Edling; R Townsend; Ute Koch; Swati Choksi; Markus Germann; Robert Korngold; Ziwei Huang
Bioactive peptide design based on protein surface epitopes. A cyclic heptapeptide mimics CD4 domain 1 CC' loop and inhibits CD4 biological function.
The Journal of biological chemistry 1997;272(18):12175-80.
1997: Shengwen Li; J Gao; T Satoh; Thea M Friedman; Andrea E Edling; Ute Koch; Swati Choksi; X Han; Robert Korngold; Ziwei Huang
A computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):73-8.
1996: Thea M Friedman; A P Reddy; R Wassell; B A Jameson; Robert Korngold
Identification of a human CD4-CDR3-like surface involved in CD4+ T cell function.
The Journal of biological chemistry 1996;271(37):22635-40.
1996: T Satoh; S Li; Thea M Friedman; R Wiaderkiewicz; R Korngold; Ziwei Huang
Synthetic peptides derived from the fourth domain of CD4 antagonize off function and inhibit T cell activation.
Biochemical and biophysical research communications 1996;224(2):438-43.