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Bärbel Friedrich

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Johannes Fritsch; Oliver Lenz; Bärbel Friedrich
Structure, function and biosynthesis of O₂-tolerant hydrogenases.
Ingmar Bürstel; Bärbel Friedrich; Philipp Hummel; Elisabeth Siebert; Gordon Winter; Ingo Zebger; Oliver Lenz
A universal scaffold for synthesis of the Fe(CN)2(CO) moiety of [NiFe] hydrogenase.
Steffen Lütte; Anne Pohlmann; Edward Schwartz; Evgeny Zaychikov; Johannes R Becher; Hermann Heumann; Bärbel Friedrich
Autotrophic production of stable-isotope-labeled arginine in Ralstonia eutropha strain H16.

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All Publications

2013: Johannes Fritsch; Oliver Lenz; Bärbel Friedrich
Structure, function and biosynthesis of O₂-tolerant hydrogenases.
Nature reviews. Microbiology 2013;11(2):106-14.
2012: Ingmar Bürstel; Bärbel Friedrich; Philipp Hummel; Elisabeth Siebert; Gordon Winter; Ingo Zebger; Oliver Lenz
A universal scaffold for synthesis of the Fe(CN)2(CO) moiety of [NiFe] hydrogenase.
The Journal of biological chemistry 2012;287(46):38845-53.
2012: Steffen Lütte; Anne Pohlmann; Edward Schwartz; Evgeny Zaychikov; Johannes R Becher; Hermann Heumann; Bärbel Friedrich
Autotrophic production of stable-isotope-labeled arginine in Ralstonia eutropha strain H16.
Applied and environmental microbiology 2012;78(22):7884-90.
2011: Johannes Fritsch; Sebastian Kroschinsky; Oliver Lenz; Patrick Scheerer; Bärbel Friedrich; Stefan Frielingsdorf; Christian M T Spahn
The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre.
Nature 2011;479(7372):249-52.
2011: Murat Sezer; Tillman Utesch; Ingo Zebger; Bärbel Friedrich; Stefan Frielingsdorf; Nina Heidary; Peter Hildebrandt; Diego Millo; Maria Andrea Mroginski; Inez M Weidinger
Role of the HoxZ subunit in the electron transfer pathway of the membrane-bound [NiFe]-hydrogenase from Ralstonia eutropha immobilized on electrodes.
The journal of physical chemistry. B 2011;115(34):10368-74.
2011: Anja Poehlein; Rolf Daniel; Bärbel Friedrich; Bernhard Kusian; Botho Bowien
Complete genome sequence of the type strain Cupriavidus necator N-1.
Journal of bacteriology 2011;193(18):5017.
2011: Johannes Fritsch; Holger Dau; Antonio L De Lacey; Bärbel Friedrich; Oliver Lenz; Simone Löscher; Marcus Ludwig; Oliver Sanganas; Elisabeth Siebert; Matthias Stein; Ingo Zebger; Michael Haumann
[NiFe] and [FeS] cofactors in the membrane-bound hydrogenase of Ralstonia eutropha investigated by X-ray absorption spectroscopy: insights into O(2)-tolerant H(2) cleavage.
Biochemistry 2011;50(26):5858-69.
2011: Yvonne Kohlmann; Steffen Lütte; Andreas Otto; Anne Pohlmann; Edward Schwartz; Dörte Becher; Rainer Cramm; Michael Hecker; Bärbel Friedrich
Analyses of soluble and membrane proteomes of Ralstonia eutropha H16 reveal major changes in the protein complement in adaptation to lithoautotrophy.
Journal of proteome research 2011;10(6):2767-76.
2011: Bärbel Friedrich; Johannes Fritsch; Oliver Lenz
Oxygen-tolerant hydrogenases in hydrogen-based technologies.
Current opinion in biotechnology 2011;22(3):358-64.
2011: Johannes Fritsch; Oliver Lenz; Bärbel Friedrich
The maturation factors HoxR and HoxT contribute to oxygen tolerance of membrane-bound [NiFe] hydrogenase in Ralstonia eutropha H16.
Journal of bacteriology 2011;193(10):2487-97.
2011: Tobias Goris; Annemarie F Wait; Miguel Saggu; Johannes Fritsch; Nina Heidary; Matthias Stein; Ingo Zebger; Friedhelm Lendzian; Fraser A Armstrong; Bärbel Friedrich; Oliver Lenz
A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase.
Nature chemical biology 2011;7(5):310-8.
2010: James A Cracknell; Bärbel Friedrich; Fraser A Armstrong
Gas pressure effects on the rates of catalytic H(2) oxidation by hydrogenases.
Chemical communications (Cambridge, England) 2010;46(44):8463-5.
2010: Miguel Saggu; Marcus Ludwig; Bärbel Friedrich; Peter Hildebrandt; Robert Bittl; Friedhelm Lendzian; Oliver Lenz; Ingo Zebger
Impact of amino acid substitutions near the catalytic site on the spectral properties of an O2-tolerant membrane-bound [NiFe] hydrogenase.
Chemphyschem : a European journal of chemical physics and physical chemistry 2010;11(6):1215-24.
2010: Simone Löscher; Antje Gebler; Matthias Stein; Oliver Sanganas; Thorsten Buhrke; Ingo Zebger; Holger Dau; Bärbel Friedrich; Oliver Lenz; Michael Haumann
Protein-protein complex formation affects the Ni-Fe and Fe-S centers in the H2-sensing regulatory hydrogenase from Ralstonia eutropha H16.
Chemphyschem : a European journal of chemical physics and physical chemistry 2010;11(6):1297-306.
2010: Oliver Lenz; Marcus Ludwig; Torsten Schubert; Ingmar Bürstel; Stefanie Ganskow; Tobias Goris; Alexander Schwarze; Bärbel Friedrich
H2 conversion in the presence of O2 as performed by the membrane-bound [NiFe]-hydrogenase of Ralstonia eutropha.
Chemphyschem : a European journal of chemical physics and physical chemistry 2010;11(6):1107-19.
2010: Gordon Winter; Simon Dökel; Anne K Jones; Patrick Scheerer; Norbert Krauss; Wolfgang Ernst Hoehne; Bärbel Friedrich
Crystallization and preliminary X-ray crystallographic analysis of the [NiFe]-hydrogenase maturation factor HypF1 from Ralstonia eutropha H16.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 4):452-5.
2010: Miguel Saggu; Christian Teutloff; Marcus Ludwig; Marc Brecht; Maria-Eirini Pandelia; Oliver Lenz; Bärbel Friedrich; Wolfgang Lubitz; Peter Hildebrandt; Friedhelm Lendzian; Robert Bittl
Comparison of the membrane-bound [NiFe] hydrogenases from R. eutropha H16 and D. vulgaris Miyazaki F in the oxidized ready state by pulsed EPR.
Physical chemistry chemical physics : PCCP 2010;12(9):2139-48.
2009: James A Cracknell; Annemarie F Wait; Oliver Lenz; Bärbel Friedrich; Fraser A Armstrong
A kinetic and thermodynamic understanding of O2 tolerance in [NiFe]-hydrogenases.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20681-6.
2009: Edward Schwartz; Birgit Voigt; Daniela Zühlke; Anne Pohlmann; Oliver Lenz; Dirk Albrecht; Alexander Schwarze; Yvonne Kohlmann; Cornelia Krause; Michael Hecker; Bärbel Friedrich
A proteomic view of the facultatively chemolithoautotrophic lifestyle of Ralstonia eutropha H16.
Proteomics 2009;9(22):5132-42.
2009: Miguel Saggu; Ingo Zebger; Marcus Ludwig; Oliver Lenz; Bärbel Friedrich; Peter Hildebrandt; Friedhelm Lendzian
Spectroscopic insights into the oxygen-tolerant membrane-associated [NiFe] hydrogenase of Ralstonia eutropha H16.
The Journal of biological chemistry 2009;284(24):16264-76.
2009: Marcus Ludwig; Torsten Schubert; Ingo Zebger; Nattawadee Wisitruangsakul; Miguel Saggu; Angelika Strack; Oliver Lenz; Peter Hildebrandt; Bärbel Friedrich
Concerted action of two novel auxiliary proteins in assembly of the active site in a membrane-bound [NiFe] hydrogenase.
The Journal of biological chemistry 2009;284(4):2159-68.
2009: Nattawadee Wisitruangsakul; Oliver Lenz; Marcus Ludwig; Bärbel Friedrich; Friedhelm Lendzian; Peter Hildebrandt; Ingo Zebger
Monitoring catalysis of the membrane-bound hydrogenase from Ralstonia eutropha H16 by surface-enhanced IR absorption spectroscopy.
Angewandte Chemie (International ed. in English) 2009;48(3):611-3.
2008: Gabrielle Goldet; Annemarie F Wait; James A Cracknell; Kylie A Vincent; Marcus Ludwig; Oliver Lenz; Bärbel Friedrich; Fraser A Armstrong
Hydrogen production under aerobic conditions by membrane-bound hydrogenases from Ralstonia species.
Journal of the American Chemical Society 2008;130(33):11106-13.
2008: Matthias Raberg; Frank Reinecke; Rudolf Reichelt; Ursula Malkus; Simone Koenig; Markus Pötter; W. Florian Fricke; Anne Pohlmann; Birgit Voigt; Michael Hecker; Bärbel Friedrich; Botho Bowien; Alexander Steinbüchel
Ralstonia eutropha H16 flagellation changes according to nutrient supply and state of poly(3-hydroxybutyrate) accumulation.
Applied and environmental microbiology 2008;74(14):4477-90.
2008: James A Cracknell; Kylie A Vincent; Marcus Ludwig; Oliver Lenz; Bärbel Friedrich; Fraser A Armstrong
Enzymatic oxidation of H2 in atmospheric O2: the electrochemistry of energy generation from trace H2 by aerobic microorganisms.
Journal of the American Chemical Society 2008;130(2):424-5.
2007: Torsten Schubert; Oliver Lenz; Eberhard Krause; Rudolf Volkmer; Bärbel Friedrich
Chaperones specific for the membrane-bound [NiFe]-hydrogenase interact with the Tat signal peptide of the small subunit precursor in Ralstonia eutropha H16.
Molecular microbiology 2007;66(2):453-67.
2007: Oliver Lenz; Ingo Zebger; Josta Hamann; Peter Hildebrandt; Bärbel Friedrich
Carbamoylphosphate serves as the source of CN(-), but not of the intrinsic CO in the active site of the regulatory [NiFe]-hydrogenase from Ralstonia eutropha.
FEBS letters 2007;581(17):3322-6.
2007: Antje Gebler; Tanja Burgdorf; Antonio L De Lacey; Olaf Rüdiger; Arturo Martinez-Arias; Oliver Lenz; Bärbel Friedrich
Impact of alterations near the [NiFe] active site on the function of the H(2) sensor from Ralstonia eutropha.
The FEBS journal 2007;274(1):74-85.
2006: Kylie A Vincent; James A Cracknell; Jeremy R Clark; Marcus Ludwig; Oliver Lenz; Bärbel Friedrich; Fraser A Armstrong
Electricity from low-level H2 in still air--an ultimate test for an oxygen tolerant hydrogenase.
Chemical communications (Cambridge, England) 2006;(48):5033-5.
2006: Anne Pohlmann; W. Florian Fricke; Frank Reinecke; Bernhard Kusian; Heiko Liesegang; Rainer Cramm; Thomas Eitinger; Christian Ewering; Markus Pötter; Edward Schwartz; Axel Strittmatter; Ingo Voss; Gerhard Gottschalk; Alexander Steinbüchel; Bärbel Friedrich; Botho Bowien
Genome sequence of the bioplastic-producing "Knallgas" bacterium Ralstonia eutropha H16.
Nature biotechnology 2006;24(10):1257-62.
2006: Simone Löscher; Tanja Burgdorf; Ingo Zebger; Peter Hildebrandt; Holger Dau; Bärbel Friedrich; Michael Haumann
Bias from H2 cleavage to production and coordination changes at the Ni-Fe active site in the NAD+-reducing hydrogenase from Ralstonia eutropha.
Biochemistry 2006;45(38):11658-65.
2006: Eddy van der Linden; Tanja Burgdorf; Antonio L De Lacey; Thorsten Buhrke; Marcel Scholte; Victor M Fernandez; Bärbel Friedrich; Simon P J Albracht
An improved purification procedure for the soluble [NiFe]-hydrogenase of Ralstonia eutropha: new insights into its (in)stability and spectroscopic properties.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(2):247-60.
2005: Kylie A Vincent; Alison Parkin; Oliver Lenz; Simon P J Albracht; Juan C Fontecilla-Camps; Richard Cammack; Bärbel Friedrich; Fraser A Armstrong
Electrochemical definitions of O2 sensitivity and oxidative inactivation in hydrogenases.
Journal of the American Chemical Society 2005;127(51):18179-89.
2005: Kylie A Vincent; James A Cracknell; Oliver Lenz; Ingo Zebger; Bärbel Friedrich; Fraser A Armstrong
Electrocatalytic hydrogen oxidation by an enzyme at high carbon monoxide or oxygen levels.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):16951-4.
2005: Oliver Lenz; Andrea Gleiche; Angelika Strack; Bärbel Friedrich
Requirements for heterologous production of a complex metalloenzyme: the membrane-bound [NiFe] hydrogenase.
Journal of bacteriology 2005;187(18):6590-5.
2005: Gordon Winter; Thorsten Buhrke; Oliver Lenz; Anne K Jones; Michael Forgber; Bärbel Friedrich
A model system for [NiFe] hydrogenase maturation studies: Purification of an active site-containing hydrogenase large subunit without small subunit.
FEBS letters 2005;579(20):4292-6.
2005: Thorsten Buhrke; Oliver Lenz; Norbert Krauss; Bärbel Friedrich
Oxygen tolerance of the H2-sensing [NiFe] hydrogenase from Ralstonia eutropha H16 is based on limited access of oxygen to the active site.
The Journal of biological chemistry 2005;280(25):23791-6.
2005: Thorsten Buhrke; Simone Löscher; Oliver Lenz; Eberhard Schlodder; Ingo Zebger; Lars K Andersen; Peter Hildebrandt; Wolfram Meyer-Klaucke; Holger Dau; Bärbel Friedrich; Michael Haumann
Reduction of unusual iron-sulfur clusters in the H2-sensing regulatory Ni-Fe hydrogenase from Ralstonia eutropha H16.
The Journal of biological chemistry 2005;280(20):19488-95.
2005: Tanja Burgdorf; Eddy van der Linden; Michael Bernhard; Qing Yuan Yin; Jaap Willem Back; Aloysius F Hartog; Anton O Muijsers; Chris G de Koster; Simon P J Albracht; Bärbel Friedrich
The soluble NAD+-Reducing [NiFe]-hydrogenase from Ralstonia eutropha H16 consists of six subunits and can be specifically activated by NADPH.
Journal of bacteriology 2005;187(9):3122-32.
2005: Andrea Büsch; Katja Strube; Bärbel Friedrich; Rainer Cramm
Transcriptional regulation of nitric oxide reduction in Ralstonia eutropha H16.
Biochemical Society transactions 2005;33(Pt 1):193-4.
2005: Bärbel Friedrich; Thorsten Buhrke; Tanja Burgdorf; Oliver Lenz
A hydrogen-sensing multiprotein complex controls aerobic hydrogen metabolism in Ralstonia eutropha.
Biochemical Society transactions 2005;33(Pt 1):97-101.
2005: Simone Löscher; Tanja Burgdorf; Thorsten Buhrke; Bärbel Friedrich; Holger Dau; Michael Haumann
Non-standard structures of the Ni-Fe cofactor in the regulatory and the NAD-reducing hydrogenases from Ralstonia eutropha.
Biochemical Society transactions 2005;33(Pt 1):25-7.
2005: Tanja Burgdorf; Simone Löscher; Peter Liebisch; Eddy van der Linden; Marcus Galander; Friedhelm Lendzian; Wolfram Meyer-Klaucke; Simon P J Albracht; Bärbel Friedrich; Holger Dau; Michael Haumann
Structural and oxidation-state changes at its nonstandard Ni-Fe site during activation of the NAD-reducing hydrogenase from Ralstonia eutropha detected by X-ray absorption, EPR, and FTIR spectroscopy.
Journal of the American Chemical Society 2005;127(2):576-92.
2005: Tanja Burgdorf; Oliver Lenz; Thorsten Buhrke; Eddy van der Linden; Anne K Jones; Simon P J Albracht; Bärbel Friedrich
[NiFe]-hydrogenases of Ralstonia eutropha H16: modular enzymes for oxygen-tolerant biological hydrogen oxidation.
Journal of molecular microbiology and biotechnology 2005;10(2-4):181-96.
2004: Andrea Büsch; Anne Pohlmann; Bärbel Friedrich; Rainer Cramm
A DNA region recognized by the nitric oxide-responsive transcriptional activator NorR is conserved in beta- and gamma-proteobacteria.
Journal of bacteriology 2004;186(23):7980-7.
2004: Boris Bleijlevens; Thorsten Buhrke; Eddy van der Linden; Bärbel Friedrich; Simon P J Albracht
The auxiliary protein HypX provides oxygen tolerance to the soluble [NiFe]-hydrogenase of ralstonia eutropha H16 by way of a cyanide ligand to nickel.
The Journal of biological chemistry 2004;279(45):46686-91.
2004: Anne K Jones; Oliver Lenz; Angelika Strack; Thorsten Buhrke; Bärbel Friedrich
NiFe hydrogenase active site biosynthesis: identification of Hyp protein complexes in Ralstonia eutropha.
Biochemistry 2004;43(42):13467-77.
2004: Gordon Winter; Thorsten Buhrke; Anne K Jones; Bärbel Friedrich
The role of the active site-coordinating cysteine residues in the maturation of the H2-sensing [NiFe] hydrogenase from Ralstonia eutropha H16.
Archives of microbiology 2004;182(2-3):138-46.
2004: Markus Pötter; Helena Müller; Frank Reinecke; Roman Wieczorek; W. Florian Fricke; Botho Bowien; Bärbel Friedrich; Alexander Steinbüchel
The complex structure of polyhydroxybutyrate (PHB) granules: four orthologous and paralogous phasins occur in Ralstonia eutropha.
Microbiology (Reading, England) 2004;150(Pt 7):2301-11.
2004: Eddy van der Linden; Tanja Burgdorf; Michael Bernhard; Boris Bleijlevens; Bärbel Friedrich; Simon P J Albracht
The soluble [NiFe]-hydrogenase from Ralstonia eutropha contains four cyanides in its active site, one of which is responsible for the insensitivity towards oxygen.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(5):616-26.
2004: Thorsten Buhrke; Oliver Lenz; Antje Porthun; Bärbel Friedrich
The H2-sensing complex of Ralstonia eutropha: interaction between a regulatory [NiFe] hydrogenase and a histidine protein kinase.
Molecular microbiology 2004;51(6):1677-89.
2004: Eddy van der Linden; Bart W Faber; Boris Bleijlevens; Tanja Burgdorf; Michael Bernhard; Bärbel Friedrich; Simon P J Albracht
Selective release and function of one of the two FMN groups in the cytoplasmic NAD+-reducing [NiFe]-hydrogenase from Ralstonia eutropha.
European journal of biochemistry / FEBS 2004;271(4):801-8.
2003: Marc Brecht; Maurice van Gastel; Thorsten Buhrke; Bärbel Friedrich; Wolfgang Lubitz
Direct detection of a hydrogen ligand in the [NiFe] center of the regulatory H2-sensing hydrogenase from Ralstonia eutropha in its reduced state by HYSCORE and ENDOR spectroscopy.
Journal of the American Chemical Society 2003;125(43):13075-83.
2003: Michael Haumann; Antje Porthun; Thorsten Buhrke; Peter Liebisch; Wolfram Meyer-Klaucke; Bärbel Friedrich; Holger Dau
Hydrogen-induced structural changes at the nickel site of the regulatory [NiFe] hydrogenase from Ralstonia eutropha detected by X-ray absorption spectroscopy.
Biochemistry 2003;42(37):11004-15.
2003: Edward Schwartz; Anke Henne; Rainer Cramm; Thomas Eitinger; Bärbel Friedrich; Gerhard Gottschalk
Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H(2)-based ithoautotrophy and anaerobiosis.
Journal of molecular biology 2003;332(2):369-83.
2002: Tanja Burgdorf; Antonio L De Lacey; Bärbel Friedrich
Functional analysis by site-directed mutagenesis of the NAD(+)-reducing hydrogenase from Ralstonia eutropha.
Journal of bacteriology 2002;184(22):6280-8.
2002: Thorsten Buhrke; Marc Brecht; Wolfgang Lubitz; Bärbel Friedrich
The H(2) sensor of Ralstonia eutropha: biochemical and spectroscopic analysis of mutant proteins modified at a conserved glutamine residue close to the [NiFe] active site.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(7-8):897-908.
2002: Oliver Lenz; Michael Bernhard; Thorsten Buhrke; Edward Schwartz; Bärbel Friedrich
The hydrogen-sensing apparatus in Ralstonia eutropha.
Journal of molecular microbiology and biotechnology 2002;4(3):255-62.
2002: Bärbel Friedrich
Regulatory networks in prokaryotes: variations on a theme.
Journal of molecular microbiology and biotechnology 2002;4(3):171-3.
2002: Andrea Büsch; Bärbel Friedrich; Rainer Cramm
Characterization of the norB gene, encoding nitric oxide reductase, in the nondenitrifying cyanobacterium Synechocystis sp. strain PCC6803.
Applied and environmental microbiology 2002;68(2):668-72.
2002: Antje Porthun; Michael Bernhard; Bärbel Friedrich
Expression of a functional NAD-reducing [NiFe] hydrogenase from the gram-positive Rhodococcus opacus in the gram-negative Ralstonia eutropha.
Archives of microbiology 2002;177(2):159-66.
2001: Thorsten Buhrke; Boris Bleijlevens; Simon P J Albracht; Bärbel Friedrich
Involvement of hyp gene products in maturation of the H(2)-sensing [NiFe] hydrogenase of Ralstonia eutropha.
Journal of bacteriology 2001;183(24):7087-93.
2001: Edward Schwartz; Bärbel Friedrich
A physical map of the megaplasmid pHG1, one of three genomic replicons in Ralstonia eutropha H16.
FEMS microbiology letters 2001;201(2):213-9.
2001: Michael Bernhard; Thorsten Buhrke; Boris Bleijlevens; Antonio L De Lacey; Victor M Fernandez; Simon P J Albracht; Bärbel Friedrich
The H2 sensor of Ralstonia eutropha. Biochemical characteristics, spectroscopic properties, and its interaction with a histidine protein kinase.
The Journal of biological chemistry 2001;276(19):15592-7.
2000: Anne Pohlmann; Rainer Cramm; K Schmelz; Bärbel Friedrich
A novel NO-responding regulator controls the reduction of nitric oxide in Ralstonia eutropha.
Molecular microbiology 2000;38(3):626-38.
2000: L Kleihues; Oliver Lenz; Michael Bernhard; Thorsten Buhrke; Bärbel Friedrich
The H(2) sensor of Ralstonia eutropha is a member of the subclass of regulatory [NiFe] hydrogenases.
Journal of bacteriology 2000;182(10):2716-24.
2000: Michael Bernhard; Bärbel Friedrich; RA Siddiqui
Ralstonia eutropha TF93 is blocked in tat-mediated protein export.
Journal of bacteriology 2000;182(3):581-8.
2000: RP Happe; Winfried Roseboom; G Egert; Cornelius G Friedrich; C Massanz; Bärbel Friedrich; Simon P J Albracht
Unusual FTIR and EPR properties of the H2-activating site of the cytoplasmic NAD-reducing hydrogenase from Ralstonia eutropha.
FEBS letters 2000;466(2-3):259-63.
1999: C Massanz; Bärbel Friedrich
Amino acid replacements at the H2-activating site of the NAD-reducing hydrogenase from Alcaligenes eutrophus.
Biochemistry 1999;38(43):14330-7.
1999: Rainer Cramm; Anne Pohlmann; Bärbel Friedrich
Purification and characterization of the single-component nitric oxide reductase from Ralstonia eutropha H16.
FEBS letters 1999;460(1):6-10.
1999: Edward Schwartz; Thorsten Buhrke; U Gerischer; Bärbel Friedrich
Positive transcriptional feedback controls hydrogenase expression in Alcaligenes eutrophus H16.
Journal of bacteriology 1999;181(18):5684-92.
1999: A Siedow; Rainer Cramm; RA Siddiqui; Bärbel Friedrich
A megaplasmid-borne anaerobic ribonucleotide reductase in Alcaligenes eutrophus H16.
Journal of bacteriology 1999;181(16):4919-28.
1998: AJ Pierik; M Schmelz; O Lenz; Bärbel Friedrich; Simon P J Albracht
Characterization of the active site of a hydrogen sensor from Alcaligenes eutrophus.
FEBS letters 1998;438(3):231-5.
1998: Thorsten Buhrke; Bärbel Friedrich
hoxX (hypX) is a functional member of the Alcaligenes eutrophus hyp gene cluster.
Archives of microbiology 1998;170(6):460-3.
1998: I Wolf; Thorsten Buhrke; J Dernedde; Anne Pohlmann; Bärbel Friedrich
Duplication of hyp genes involved in maturation of [NiFe] hydrogenases in Alcaligenes eutrophus H16.
Archives of microbiology 1998;170(6):451-9.
1998: Oliver Lenz; Bärbel Friedrich
A novel multicomponent regulatory system mediates H2 sensing in Alcaligenes eutrophus.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12474-9.
1998: Edward Schwartz; U Gerischer; Bärbel Friedrich
Transcriptional regulation of Alcaligenes eutrophus hydrogenase genes.
Journal of bacteriology 1998;180(12):3197-204.
1998: C Massanz; S Schmidt; Bärbel Friedrich
Subforms and in vitro reconstitution of the NAD-reducing hydrogenase of Alcaligenes eutrophus.
Journal of bacteriology 1998;180(5):1023-9.
1998: C Lieb; RA Siddiqui; B Hippler; D Jahn; Bärbel Friedrich
The Alcaligenes eutrophus hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase, is required for heme biosynthesis during anaerobic growth.
Archives of microbiology 1998;169(1):52-60.
1997: Rainer Cramm; RA Siddiqui; Bärbel Friedrich
Two isofunctional nitric oxide reductases in Alcaligenes eutrophus H16.
Journal of bacteriology 1997;179(21):6769-77.
1997: Michael Bernhard; B Benelli; Alejandro Hochkoeppler; Davide Zannoni; Bärbel Friedrich
Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16.
European journal of biochemistry / FEBS 1997;248(1):179-86.
1997: C Massanz; V M Fernandez; Bärbel Friedrich
C-terminal extension of the H2-activating subunit, HoxH, directs maturation of the NAD-reducing hydrogenase in Alcaligenes eutrophus.
European journal of biochemistry / FEBS 1997;245(2):441-8.
1997: Oliver Lenz; Angelika Strack; A Tran-Betcke; Bärbel Friedrich
A hydrogen-sensing system in transcriptional regulation of hydrogenase gene expression in Alcaligenes species.
Journal of bacteriology 1997;179(5):1655-63.
1997: E Rees; RA Siddiqui; F Köster; B Schneider; Bärbel Friedrich
Structural gene (nirS) for the cytochrome cd1 nitrite reductase of Alcaligenes eutrophus H16.
Applied and environmental microbiology 1997;63(2):800-2.
1996: M Bernhard; Edward Schwartz; J Rietdorf; Bärbel Friedrich
The Alcaligenes eutrophus membrane-bound hydrogenase gene locus encodes functions involved in maturation and electron transport coupling.
Journal of bacteriology 1996;178(15):4522-9.
1996: S Thiemermann; J Dernedde; M Bernhard; W Schroeder; C Massanz; Bärbel Friedrich
Carboxyl-terminal processing of the cytoplasmic NAD-reducing hydrogenase of Alcaligenes eutrophus requires the hoxW gene product.
Journal of bacteriology 1996;178(8):2368-74.
1996: J Dernedde; Thomas Eitinger; N Patenge; Bärbel Friedrich
hyp gene products in Alcaligenes eutrophus are part of a hydrogenase-maturation system.
European journal of biochemistry / FEBS 1996;235(1-2):351-8.
1995: Ulrich Ermler; RA Siddiqui; Rainer Cramm; Bärbel Friedrich
Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution.
The EMBO journal 1995;14(24):6067-77.
1995: D Zimmer; E Schwartz; A Tran-Betcke; P Gewinner; Bärbel Friedrich
Temperature tolerance of hydrogenase expression in Alcaligenes eutrophus is conferred by a single amino acid exchange in the transcriptional activator HoxA.
Journal of bacteriology 1995;177(9):2373-80.
1995: L Wolfram; Bärbel Friedrich; Thomas Eitinger
The Alcaligenes eutrophus protein HoxN mediates nickel transport in Escherichia coli.
Journal of bacteriology 1995;177(7):1840-3.
1995: Ulrich Ermler; RA Siddiqui; Rainer Cramm; D Schröder; Bärbel Friedrich
Crystallization and preliminary X-ray diffraction studies of a bacterial flavohemoglobin protein.
Proteins 1995;21(4):351-3.
1994: Oliver Lenz; E Schwartz; J Dernedde; M Eitinger; Bärbel Friedrich
The Alcaligenes eutrophus H16 hoxX gene participates in hydrogenase regulation.
Journal of bacteriology 1994;176(14):4385-93.
1994: Thomas Eitinger; Bärbel Friedrich
A topological model for the high-affinity nickel transporter of Alcaligenes eutrophus.
Molecular microbiology 1994;12(6):1025-32.
1994: Rainer Cramm; RA Siddiqui; Bärbel Friedrich
Primary sequence and evidence for a physiological function of the flavohemoprotein of Alcaligenes eutrophus.
The Journal of biological chemistry 1994;269(10):7349-54.
1994: R Sann; S Kostka; Bärbel Friedrich
A cytochrome cd1-type nitrite reductase mediates the first step of denitrification in Alcaligenes eutrophus.
Archives of microbiology 1994;161(6):453-9.
1993: RA Siddiqui; U Warnecke-Eberz; Anja Lamprecht; B Schneider; S Kostka; Bärbel Friedrich
Structure and function of a periplasmic nitrate reductase in Alcaligenes eutrophus H16.
Journal of bacteriology 1993;175(18):5867-76.
1993: J Dernedde; M Eitinger; Bärbel Friedrich
Analysis of a pleiotropic gene region involved in formation of catalytically active hydrogenases in Alcaligenes eutrophus H16.
Archives of microbiology 1993;159(6):545-53.
1993: Bärbel Friedrich; E Schwartz
Molecular biology of hydrogen utilization in aerobic chemolithotrophs.
Annual review of microbiology 1993;47():351-83.
1992: C Kortlüke; Bärbel Friedrich
Maturation of membrane-bound hydrogenase of Alcaligenes eutrophus H16.
Journal of bacteriology 1992;174(19):6290-3.
1992: C Kortlüke; K Horstmann; E Schwartz; M Rohde; R Binsack; Bärbel Friedrich
A gene complex coding for the membrane-bound hydrogenase of Alcaligenes eutrophus H16.
Journal of bacteriology 1992;174(19):6277-89.
1992: Christopher Rensing; U Kües; Ulf Stahl; Dietrich H Nies; Bärbel Friedrich
Expression of bacterial mercuric ion reductase in Saccharomyces cerevisiae.
Journal of bacteriology 1992;174(4):1288-92.
1992: J Warrelmann; M Eitinger; E Schwartz; D Römermann; Bärbel Friedrich
Nucleotide sequence of the rpoN (hno) gene region of Alcaligenes eutrophus: evidence for a conserved gene cluster.
Archives of microbiology 1992;158(2):107-14.
1991: C Dressler; U Kües; Dietrich H Nies; Bärbel Friedrich
Determinants encoding resistance to several heavy metals in newly isolated copper-resistant bacteria.
Applied and environmental microbiology 1991;57(11):3079-85.
1991: L Wolfram; Thomas Eitinger; Bärbel Friedrich
Construction and properties of a triprotein containing the high-affinity nickel transporter of Alcaligenes eutrophus.
FEBS letters 1991;283(1):109-12.
1991: G Eberz; Bärbel Friedrich
Three trans-acting regulatory functions control hydrogenase synthesis in Alcaligenes eutrophus.
Journal of bacteriology 1991;173(6):1845-54.
1991: Thomas Eitinger; Bärbel Friedrich
Cloning, nucleotide sequence, and heterologous expression of a high-affinity nickel transport gene from Alcaligenes eutrophus.
The Journal of biological chemistry 1991;266(5):3222-7.
1990: R A Bender; Bärbel Friedrich
Regulation of assimilatory nitrate reductase formation in Klebsiella aerogenes W70.
Journal of bacteriology 1990;172(12):7256-9.
1990: A Tran-Betcke; U Warnecke; C Böcker; C Zaborosch; Bärbel Friedrich
Cloning and nucleotide sequences of the genes for the subunits of NAD-reducing hydrogenase of Alcaligenes eutrophus H16.
Journal of bacteriology 1990;172(6):2920-9.
1989: K Fiebig; Bärbel Friedrich
Purification of the F420-reducing hydrogenase from Methanosarcina barkeri (strain Fusaro).
European journal of biochemistry / FEBS 1989;184(1):79-88.
1989: G Eberz; Thomas Eitinger; Bärbel Friedrich
Genetic determinants of a nickel-specific transport system are part of the plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus.
Journal of bacteriology 1989;171(3):1340-5.
1989: D Römermann; J Warrelmann; R A Bender; Bärbel Friedrich
An rpoN-like gene of Alcaligenes eutrophus and Pseudomonas facilis controls expression of diverse metabolic pathways, including hydrogen oxidation.
Journal of bacteriology 1989;171(2):1093-9.
1988: B Schneider; A Nies; Bärbel Friedrich
Transfer and expression of lithoautotrophy and denitrification in a host lacking these metabolic activities.
Applied and environmental microbiology 1988;54(12):3173-6.
1987: D Nies; Max Mergeay; Bärbel Friedrich; H G Schlegel
Cloning of plasmid genes encoding resistance to cadmium, zinc, and cobalt in Alcaligenes eutrophus CH34.
Journal of bacteriology 1987;169(10):4865-8.
1986: G Eberz; C Hogrefe; C Kortlüke; A Kamienski; Bärbel Friedrich
Molecular cloning of structural and regulatory hydrogenase (hox) genes of Alcaligenes eutrophus H16.
Journal of bacteriology 1986;168(2):636-41.
1986: Bärbel Friedrich; C Kortlüke; C Hogrefe; G Eberz; B Silber; J Warrelmann
Genetics of hydrogenase from aerobic lithoautotrophic bacteria.
Biochimie 1986;68(1):133-45.
1985: D Römermann; Bärbel Friedrich
Denitrification by Alcaligenes eutrophus is plasmid dependent.
Journal of bacteriology 1985;162(2):852-4.
1984: C Hogrefe; Bärbel Friedrich
Isolation and characterization of megaplasmid DNA from lithoautotrophic bacteria.
Plasmid 1984;12(3):161-9.
1984: C Hogrefe; D Römermann; Bärbel Friedrich
Alcaligenes eutrophus hydrogenase genes (Hox).
Journal of bacteriology 1984;158(1):43-8.
1981: Bärbel Friedrich; C Hogrefe; H G Schlegel
Naturally occurring genetic transfer of hydrogen-oxidizing ability between strains of Alcaligenes eutrophus.
Journal of bacteriology 1981;147(1):198-205.