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Paul Friesen

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Jonathan K Mitchell; Paul D Friesen
Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication.
David J Taggart; Jonathan K Mitchell; Paul D Friesen
A conserved N-terminal domain mediates required DNA replication activities and phosphorylation of the transcriptional activator IE1 of Autographa californica multicapsid nucleopolyhedrovirus.
Rianna Vandergaast; Kimberly L W Schultz; Rebecca Cerio; Paul D Friesen
Active depletion of host cell inhibitor-of-apoptosis proteins triggers apoptosis upon baculovirus DNA replication.

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All Publications

2012: Jonathan K Mitchell; Paul D Friesen
Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication.
Journal of virology 2012;86(24):13542-53.
2012: David J Taggart; Jonathan K Mitchell; Paul D Friesen
A conserved N-terminal domain mediates required DNA replication activities and phosphorylation of the transcriptional activator IE1 of Autographa californica multicapsid nucleopolyhedrovirus.
Journal of virology 2012;86(12):6575-85.
2011: Rianna Vandergaast; Kimberly L W Schultz; Rebecca Cerio; Paul D Friesen
Active depletion of host cell inhibitor-of-apoptosis proteins triggers apoptosis upon baculovirus DNA replication.
Journal of virology 2011;85(16):8348-58.
2010: Benjamin G Kopek; Erik W Settles; Paul D Friesen; Paul Ahlquist
Nodavirus-induced membrane rearrangement in replication complex assembly requires replicase protein a, RNA templates, and polymerase activity.
Journal of virology 2010;84(24):12492-503.
2010: Rebecca Cerio; Rianna Vandergaast; Paul D Friesen
Host insect inhibitor-of-apoptosis SfIAP functionally replaces baculovirus IAP but is differentially regulated by Its N-terminal leader.
Journal of virology 2010;84(21):11448-60.
2009: Kimberly Schultz; Paul D Friesen
Baculovirus DNA replication-specific expression factors trigger apoptosis and shutoff of host protein synthesis during infection.
Journal of virology 2009;83(21):11123-32.
2009: Kimberly Schultz; Justin A Wetter; Diccon C Fiore; Paul D Friesen
Transactivator IE1 is required for baculovirus early replication events that trigger apoptosis in permissive and nonpermissive cells.
Journal of virology 2009;83(1):262-72.
2008: Michael P Guy; Paul D Friesen
Reactive-site cleavage residues confer target specificity to baculovirus P49, a dimeric member of the P35 family of caspase inhibitors.
Journal of virology 2008;82(15):7504-14.
2008: Erik W Settles; Paul D Friesen
Flock house virus induces apoptosis by depletion of Drosophila inhibitor-of-apoptosis protein DIAP1.
Journal of virology 2008;82(3):1378-88.
2007: Erica Lannan; Rianna Vandergaast; Paul D Friesen
Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation in Drosophila melanogaster cells.
Journal of virology 2007;81(17):9319-30.
2004: Charles M Forsyth; Donna Lemongello; Douglas J LaCount; Paul D Friesen; Andrew J Fisher
Crystal structure of an invertebrate caspase.
The Journal of biological chemistry 2004;279(8):7001-8.
2003: Victoria A Olson; Justin A Wetter; Paul D Friesen
The highly conserved basic domain I of baculovirus IE1 is required for hr enhancer DNA binding and hr-dependent transactivation.
Journal of virology 2003;77(10):5668-77.
2002: Stephen J Zoog; Jennifer J Schiller; Justin A Wetter; Nor Chejanovsky; Paul D Friesen
Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo.
The EMBO journal 2002;21(19):5130-40.
2002: Victoria A Olson; Justin A Wetter; Paul D Friesen
Baculovirus transregulator IE1 requires a dimeric nuclear localization element for nuclear import and promoter activation.
Journal of virology 2002;76(18):9505-15.
2002: Michael J Eddins; Donna Lemongello; Paul D Friesen; Andrew J Fisher
Crystallization and low-resolution structure of an effector-caspase/P35 complex: similarities and differences to an initiator-caspase/P35 complex.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 2):299-302.
2001: W P dela Cruz; Paul D Friesen; Andrew J Fisher
Crystal structure of baculovirus P35 reveals a novel conformational change in the reactive site loop after caspase cleavage.
The Journal of biological chemistry 2001;276(35):32933-9.
2001: Victoria A Olson; Justin A Wetter; Paul D Friesen
Oligomerization mediated by a helix-loop-helix-like domain of baculovirus IE1 is required for early promoter transactivation.
Journal of virology 2001;75(13):6042-51.
2001: Gulam Manji; Paul D Friesen
Apoptosis in motion. An apical, P35-insensitive caspase mediates programmed cell death in insect cells.
The Journal of biological chemistry 2001;276(20):16704-10.
2000: Douglas J LaCount; S F Hanson; C L Schneider; Paul D Friesen
Caspase inhibitor P35 and inhibitor of apoptosis Op-IAP block in vivo proteolytic activation of an effector caspase at different steps.
The Journal of biological chemistry 2000;275(21):15657-64.
2000: RR Hozak; Gulam Manji; Paul D Friesen
The BIR motifs mediate dominant interference and oligomerization of inhibitor of apoptosis Op-IAP.
Molecular and cellular biology 2000;20(5):1877-85.
1999: Stephen J Zoog; J Bertin; Paul D Friesen
Caspase inhibition by baculovirus P35 requires interaction between the reactive site loop and the beta-sheet core.
The Journal of biological chemistry 1999;274(37):25995-6002.
1999: Andrew J Fisher; W d Cruz; Stephen J Zoog; C L Schneider; Paul D Friesen
Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition.
The EMBO journal 1999;18(8):2031-9.
1998: I Anderson; C R Bartley; R A Lerch; W G Gray; Paul D Friesen; J Gorski
Estrogen receptor alpha requires no accessory factors for high-affinity binding to a consensus response element.
Biochemistry 1998;37(49):17287-98.
1998: K L Hajek; Paul D Friesen
Proteolytic processing and assembly of gag and gag-pol proteins of TED, a baculovirus-associated retrotransposon of the gypsy family.
Journal of virology 1998;72(11):8718-24.
1997: S M Rodems; S S Pullen; Paul D Friesen
DNA-dependent transregulation by IE1 of Autographa californica nuclear polyhedrosis virus: IE1 domains required for transactivation and DNA binding.
Journal of virology 1997;71(12):9270-7.
1997: Gulam Manji; RR Hozak; Douglas J LaCount; Paul D Friesen
Baculovirus inhibitor of apoptosis functions at or upstream of the apoptotic suppressor P35 to prevent programmed cell death.
Journal of virology 1997;71(6):4509-16.
1997: Douglas J LaCount; Paul D Friesen
Role of early and late replication events in induction of apoptosis by baculoviruses.
Journal of virology 1997;71(2):1530-7.
1996: M S Ozers; Paul D Friesen
The Env-like open reading frame of the baculovirus-integrated retrotransposon TED encodes a retrovirus-like envelope protein.
Virology 1996;226(2):252-9.
1996: John Bertin; Susan Mendrysa; Douglas J LaCount; S Gaur; JF Krebs; Robert C Armstrong; Kevin J Tomaselli; Paul D Friesen
Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease.
Journal of virology 1996;70(9):6251-9.
1995: S M Rodems; Paul D Friesen
Transcriptional enhancer activity of hr5 requires dual-palindrome half sites that mediate binding of a dimeric form of the baculovirus transregulator IE1.
Journal of virology 1995;69(9):5368-75.
1995: S S Pullen; Paul D Friesen
The CAGT motif functions as an initiator element during early transcription of the baculovirus transregulator ie-1.
Journal of virology 1995;69(6):3575-83.
1995: S S Pullen; Paul D Friesen
Early transcription of the ie-1 transregulator gene of Autographa californica nuclear polyhedrosis virus is regulated by DNA sequences within its 5' noncoding leader region.
Journal of virology 1995;69(1):156-65.
1994: J L Cartier; P A Hershberger; Paul D Friesen
Suppression of apoptosis in insect cells stably transfected with baculovirus p35: dominant interference by N-terminal sequences p35(1-76).
Journal of virology 1994;68(12):7728-37.
1994: P A Hershberger; Douglas J LaCount; Paul D Friesen
The apoptotic suppressor P35 is required early during baculovirus replication and is targeted to the cytosol of infected cells.
Journal of virology 1994;68(6):3467-77.
1994: A Sugimoto; Paul D Friesen; Joel H Rothman
Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans.
The EMBO journal 1994;13(9):2023-8.
1993: Shahrooz Rabizadeh; Douglas J LaCount; Paul D Friesen; Dale E Bredesen
Expression of the baculovirus p35 gene inhibits mammalian neural cell death.
Journal of neurochemistry 1993;61(6):2318-21.
1993: S M Rodems; Paul D Friesen
The hr5 transcriptional enhancer stimulates early expression from the Autographa californica nuclear polyhedrosis virus genome but is not required for virus replication.
Journal of virology 1993;67(10):5776-85.
1993: R A Lerch; Paul D Friesen
The 35-kilodalton protein gene (p35) of Autographa californica nuclear polyhedrosis virus and the neomycin resistance gene provide dominant selection of recombinant baculoviruses.
Nucleic acids research 1993;21(8):1753-60.
1992: P A Hershberger; J A Dickson; Paul D Friesen
Site-specific mutagenesis of the 35-kilodalton protein gene encoded by Autographa californica nuclear polyhedrosis virus: cell line-specific effects on virus replication.
Journal of virology 1992;66(9):5525-33.
1992: R A Lerch; Paul D Friesen
The baculovirus-integrated retrotransposon TED encodes gag and pol proteins that assemble into viruslike particles with reverse transcriptase.
Journal of virology 1992;66(3):1590-601.
1991: D G Gretch; Stephen L. Sturley; Paul D Friesen; N E Beckage; Alan D Attie
Baculovirus-mediated expression of human apolipoprotein E in Manduca sexta larvae generates particles that bind to the low density lipoprotein receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8530-3.
1991: J A Dickson; Paul D Friesen
Identification of upstream promoter elements mediating early transcription from the 35,000-molecular-weight protein gene of Autographa californica nuclear polyhedrosis virus.
Journal of virology 1991;65(8):4006-16.
1990: Paul D Friesen; M S Nissen
Gene organization and transcription of TED, a lepidopteran retrotransposon integrated within the baculovirus genome.
Molecular and cellular biology 1990;10(6):3067-77.
1989: M S Nissen; Paul D Friesen
Molecular analysis of the transcriptional regulatory region of an early baculovirus gene.
Journal of virology 1989;63(2):493-503.
1983: T M Gallagher; Paul D Friesen; RR Rueckert
Autonomous replication and expression of RNA 1 from black beetle virus.
Journal of virology 1983;46(2):481-9.
1982: Paul D Friesen; RR Rueckert
Black beetle virus: messenger for protein B is a subgenomic viral RNA.
Journal of virology 1982;42(3):986-95.
1981: Paul D Friesen; RR Rueckert
Synthesis of Black Beetle Virus Proteins in Cultured Drosophila Cells: Differential Expression of RNAs 1 and 2.
Journal of virology 1981;37(3):876-86.
1980: Paul D Friesen; P Scotti; J Longworth; R Rueckert
Black beetle virus: propagation in Drosophila line 1 cells and an infection-resistant subline carrying endogenous black beetle virus-related particles.
Journal of virology 1980;35(3):741-7.