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Karl-Heinrich Fritzemeier

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Paula Anahi Arias-Loza; Barbara Bayer; Stefan Frantz; Karl-Heinrich Fritzemeier; Kai Hu; Ina Israel; Franz R Kaiser; Susanne Kneitz; Kenneth S Korach; Michael C Kreissl; Theo Pelzer
The estrogen receptor-α is required and sufficient to maintain physiological glucose uptake in the mouse heart.
Melanie Muehlfelder; Paula Anahi Arias-Loza; Karl-Heinrich Fritzemeier; Theo Pelzer
Both estrogen receptor subtypes, ERα and ERβ, prevent aldosterone-induced oxidative stress in VSMC via increased NADPH bioavailability.
Martina Velders; Oliver Zierau; Karl-Heinrich Fritzemeier; Burkhardt Schleipen; Patrick Diel
Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration.

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2012: Paula Anahi Arias-Loza; Barbara Bayer; Stefan Frantz; Karl-Heinrich Fritzemeier; Kai Hu; Ina Israel; Franz R Kaiser; Susanne Kneitz; Kenneth S Korach; Michael C Kreissl; Theo Pelzer
The estrogen receptor-α is required and sufficient to maintain physiological glucose uptake in the mouse heart.
Hypertension 2012;60(4):1070-7.
2012: Melanie Muehlfelder; Paula Anahi Arias-Loza; Karl-Heinrich Fritzemeier; Theo Pelzer
Both estrogen receptor subtypes, ERα and ERβ, prevent aldosterone-induced oxidative stress in VSMC via increased NADPH bioavailability.
Biochemical and biophysical research communications 2012;423(4):850-6.
2012: Martina Velders; Oliver Zierau; Karl-Heinrich Fritzemeier; Burkhardt Schleipen; Patrick Diel
Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):1909-20.
2012: Carmen Weigt; Nora Zoth; Karl-Heinrich Fritzemeier; Torsten Hertrampf; Patrick Diel
Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity.
Molecular and cellular endocrinology 2012;351(2):227-38.
2012: Christiane Otto; Jenny Schkoldow; Christiane Schüler; Richardus Vonk; Karl-Heinrich Fritzemeier; Iris Fuchs; Ingrid Kantner; Elisabeth Krahl; Reinhard Nubbemeyer; Reinhold Erben
Estradiol release kinetics determine tissue response in ovariectomized rats.
Endocrinology 2012;153(4):1725-33.
2012: A Cleve; Karl-Heinrich Fritzemeier; B Haendler; N Heinrich; C Möller; W Schwede; Tim M Wintermantel
Pharmacology and clinical use of sex steroid hormone receptor modulators.
Handbook of experimental pharmacology 2012;(214):543-87.
2012: Astrid Menning; Karl-Heinrich Fritzemeier; Isabella Gashaw; Marion Rudolph; Alexander Walter; Lars Roese
Granulocytes and vascularization regulate uterine bleeding and tissue remodeling in a mouse menstruation model.
PloS one 2012;7(8):e41800.
2011: B Schleipen; M Velders; Karl-Heinrich Fritzemeier; Torsten Hertrampf; F M Kluxen; A Lorenz; A Molzberger; Patrick Diel
ERβ-specific agonists and genistein inhibit proliferation and induce apoptosis in the large and small intestine.
Carcinogenesis 2011;32(11):1675-83.
2010: M Velders; M Solzbacher; B Schleipen; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
Estradiol and genistein antagonize the ovariectomy effects on skeletal muscle myosin heavy chain expression via ER-beta mediated pathways.
The Journal of steroid biochemistry and molecular biology 2010;120(1):53-9.
2010: Christiane Otto; Iris Fuchs; Richardus Vonk; Karl-Heinrich Fritzemeier
Comparative analysis of the uterine and mammary gland effects of progesterone and medroxyprogesterone acetate.
Maturitas 2010;65(4):386-91.
2009: Paula Anahi Arias-Loza; Melanie Muehlfelder; Susan A Elmore; Robert Maronpot; Kai Hu; Hartmut Blode; Christa Hegele-Hartung; Karl-Heinrich Fritzemeier; Georg Ertl; Theo Pelzer
Differential effects of 17beta-estradiol and of synthetic progestins on aldosterone-salt-induced kidney disease.
Toxicologic pathology 2009;37(7):969-82.
2009: Christiane Otto; Iris Fuchs; Gunther Kauselmann; Heidrun Kern; Branko Zevnik; Puk Andreasen; Gilda Schwarz; Helga Altmann; Mario Klewer; Michael Schoor; Richardus Vonk; Karl-Heinrich Fritzemeier
GPR30 does not mediate estrogenic responses in reproductive organs in mice.
Biology of reproduction 2009;80(1):34-41.
2008: Christiane Otto; Beate Rohde-Schulz; Gilda Schwarz; Iris Fuchs; Mario Klewer; Dominic Brittain; Gernot Langer; Benjamin Bader; Katja Prelle; Reinhard Nubbemeyer; Karl-Heinrich Fritzemeier
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol.
Endocrinology 2008;149(10):4846-56.
2008: Torsten Hertrampf; B Schleipen; M Velders; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
Estrogen receptor subtype-specific effects on markers of bone homeostasis.
Molecular and cellular endocrinology 2008;291(1-2):104-8.
2008: Vladimir Patchev; Sergey O Bachurin; Michael Albers; Karl-Heinrich Fritzemeier; Vassilios Papadopoulos
Neurotrophic estrogens: essential profile and endpoints for drug discovery.
Drug discovery today 2008;13(17-18):734-47.
2008: Christiane Otto; Iris Fuchs; Helga Altmann; Mario Klewer; Alexander Walter; Katja Prelle; Richardus Vonk; Karl-Heinrich Fritzemeier
Comparative analysis of the uterine and mammary gland effects of drospirenone and medroxyprogesterone acetate.
Endocrinology 2008;149(8):3952-9.
2008: Christiane Otto; Iris Fuchs; Helga Altmann; Mario Klewer; Gilda Schwarz; Rolf Bohlmann; Duy Nguyen; Ludwig Zorn; Richardus Vonk; Katja Prelle; Thua Osterman; Chira Malmström; Karl-Heinrich Fritzemeier
In vivo characterization of estrogen receptor modulators with reduced genomic versus nongenomic activity in vitro.
The Journal of steroid biochemistry and molecular biology 2008;111(1-2):95-100.
2008: Torsten Hertrampf; Jan Seibel; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
Analysis of the effects of oestrogen receptor alpha (ERalpha)- and ERbeta-selective ligands given in combination to ovariectomized rats.
British journal of pharmacology 2008;153(7):1432-7.
2008: Virginija Jazbutyte; Paula Anahi Arias-Loza; Kai Hu; Julian Widder; Vijayakumar Govindaraj; Christine von Poser-Klein; Johann Bauersachs; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung; Ludwig Neyses; Georg Ertl; Theo Pelzer
Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats.
Cardiovascular research 2008;77(4):774-81.
2007: Torsten Hertrampf; M J Gruca; Jan Seibel; U Laudenbach; Karl-Heinrich Fritzemeier; Patrick Diel
The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity.
Bone 2007;40(6):1529-35.
2007: B E H Sumner; K E Grant; Roberta Rosie; Christa Hegele-Hartung; Karl-Heinrich Fritzemeier; George Fink
Raloxifene blocks estradiol induction of the serotonin transporter and 5-hydroxytryptamine2A receptor in female rat brain.
Neuroscience letters 2007;417(1):95-9.
2007: Stephen J McPherson; Stuart J Ellem; Evan R Simpson; Vladimir Patchev; Karl-Heinrich Fritzemeier; Gail P Risbridger
Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia.
Endocrinology 2007;148(2):566-74.
2006: Luisella Toschi; Jochen Hilbig; Tim M Wintermantel; Adelheid Engelhaupt; Alexander Walter; Karl-Heinrich Fritzemeier; Alexander Hillisch
Protein-structure-based prediction of animal model suitability for pharmacodynamic studies of subtype-selective estrogens.
ChemMedChem 2006;1(11):1237-48.
2006: Paula Anahi Arias-Loza; Kai Hu; Andreas Schäfer; Johann Bauersachs; Thomas Quaschning; Jan Galle; Virginija Jazbutyte; Ludwig Neyses; Georg Ertl; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung; Theo Pelzer
Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats.
Hypertension 2006;48(5):994-1001.
2006: Virginija Jazbutyte; Kai Hu; Patricia Kruchten; Emmanuel Bey; Sebastian K G Maier; Karl-Heinrich Fritzemeier; Katja Prelle; Christa Hegele-Hartung; Rolf W Hartmann; Ludwig Neyses; Georg Ertl; Theo Pelzer
Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats.
Hypertension 2006;48(4):579-86.
2006: C Otto; S Wessler; Karl-Heinrich Fritzemeier
Exploiting nongenomic estrogen receptor-mediated signaling for the Development of pathway-selective Estrogen receptor ligands.
Ernst Schering Foundation symposium proceedings 2006;(1):163-81.
2006: Stephen J McPherson; Stuart J Ellem; Vladimir Patchev; Karl-Heinrich Fritzemeier; Gail P Risbridger
The role of Eralpha and ERbeta in the prostate: insights from genetic models and isoform-selective ligands.
Ernst Schering Foundation symposium proceedings 2006;(1):131-47.
2006: Paula Anahi Arias-Loza; Virginija Jazbutyte; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung; Ludwig Neyses; Georg Ertl; Theo Pelzer
Functional effects and molecular mechanisms of subtype-selective ERalpha and ERbeta agonists in the cardiovascular system.
Ernst Schering Foundation symposium proceedings 2006;(1):87-106.
2006: Silja Wessler; Christiane Otto; Nicola Wilck; Verena Stangl; Karl-Heinrich Fritzemeier
Identification of estrogen receptor ligands leading to activation of non-genomic signaling pathways while exhibiting only weak transcriptional activity.
The Journal of steroid biochemistry and molecular biology 2006;98(1):25-35.
2005: Theo Pelzer; Virginija Jazbutyte; Kai Hu; Stephan Segerer; Matthias Nahrendorf; Peter Nordbeck; Andreas W Bonz; Jenny Muck; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung; Georg Ertl; Ludwig Neyses
The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats.
Cardiovascular research 2005;67(4):604-12.
2005: Johannes von Langen; Karl-Heinrich Fritzemeier; Stephan Diekmann; Alexander Hillisch
Molecular basis of the interaction specificity between the human glucocorticoid receptor and its endogenous steroid ligand cortisol.
Chembiochem : a European journal of chemical biology 2005;6(6):1110-8.
2004: Alexander Hillisch; Olaf Peters; Dirk Kosemund; Gerd Müller; Alexander Walter; Birgitt Schneider; Gudrun Reddersen; Walter Elger; Karl-Heinrich Fritzemeier
Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1599-609.
2004: Christa Hegele-Hartung; Philip Siebel; Olaf Peters; Dirk Kosemund; Gerd Müller; Alexander Hillisch; Alexander Walter; Jörn Kraetzschmar; Karl-Heinrich Fritzemeier
Impact of isotype-selective estrogen receptor agonists on ovarian function.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(14):5129-34.
2004: Karl-Heinrich Fritzemeier; Alexander Hillisch; Walter Elger; U Kaufmann; U Kollenkirchen; Dirk Kosemund; B Lindenthal; Gerd Müller; P Muhn; R Nubbemeyer; Olaf Peters; P Siebel; Christa Hegele-Hartung
Biological effects of ERalpha- and ERbeta-selective estrogens.
Ernst Schering Research Foundation workshop 2004;(46):127-50.
2004: Alexander Hillisch; Olaf Peters; Dirk Kosemund; Gerd Müller; Alexander Walter; Walter Elger; Karl-Heinrich Fritzemeier
Protein structure-based design, synthesis strategy and in vitro pharmacological characterization of estrogen receptor alpha and beta selective compounds.
Ernst Schering Research Foundation workshop 2004;(46):47-62.
2003: Julian Widder; Theo Pelzer; Christine von Poser-Klein; Kai Hu; Virginija Jazbutyte; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung; Ludwig Neyses; Johann Bauersachs
Improvement of endothelial dysfunction by selective estrogen receptor-alpha stimulation in ovariectomized SHR.
Hypertension 2003;42(5):991-6.
2003: Olaf Schaefer; Michael Hümpel; Karl-Heinrich Fritzemeier; Rolf Bohlmann; Wolf-Dieter Schleuning
8-Prenyl naringenin is a potent ERalpha selective phytoestrogen present in hops and beer.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):359-60.
2000: UU Fuhrmann; Holger Hess-Stumpp; A Cleve; G Neef; W Schwede; J Hoffmann; Karl-Heinrich Fritzemeier; Kristof Chwalisz
Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist.
Journal of medicinal chemistry 2000;43(26):5010-6.
2000: Deborah A Zajchowski; Katalin Kauser; D Zhu; L Webster; S Aberle; F A White; Hsaio-Lai Liu; R Humm; J MacRobbie; P Ponte; Christa Hegele-Hartung; R Knauthe; Karl-Heinrich Fritzemeier; Ronald Vergona; Gabor M Rubanyi
Identification of selective estrogen receptor modulators by their gene expression fingerprints.
The Journal of biological chemistry 2000;275(21):15885-94.
1999: B E H Sumner; K E Grant; Roberta Rosie; Christa Hegele-Hartung; Karl-Heinrich Fritzemeier; George Fink
Effects of tamoxifen on serotonin transporter and 5-hydroxytryptamine(2A) receptor binding sites and mRNA levels in the brain of ovariectomized rats with or without acute estradiol replacement.
Brain research. Molecular brain research 1999;73(1-2):119-28.
1998: Kristof Chwalisz; K Stöckemann; Karl-Heinrich Fritzemeier; UU Fuhrmann
Modulation of oestrogenic effects by progesterone antagonists in the rat uterus.
Human reproduction update 1998;4(5):570-83.
1998: W Schwede; Karl-Heinrich Fritzemeier; W Halfbrodt; R Krattenmacher; P Muhn; G Neef; E Ottow; K Schöllkopf
Synthesis and biological activity of 11,19-bridged progestins.
Steroids 1998;63(3):166-77.
1997: Christa Hegele-Hartung; Karl-Heinrich Fritzemeier; Patrick Diel
Effects of a pure antiestrogen and progesterone on estrogen-mediated alterations of blood flow and progesterone receptor expression in the aorta of ovariectomized rabbits.
The Journal of steroid biochemistry and molecular biology 1997;63(4-6):237-49.
1996: UU Fuhrmann; R Krattenmacher; E P Slater; Karl-Heinrich Fritzemeier
The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential.
Contraception 1996;54(4):243-51.
1996: R Knauthe; P Diel; Christa Hegele-Hartung; A Engelhaupt; Karl-Heinrich Fritzemeier
Sexual dimorphism of steroid hormone receptor messenger ribonucleic acid expression and hormonal regulation in rat vascular tissue.
Endocrinology 1996;137(8):3220-7.
1996: Horst Michna; Karl-Heinrich Fritzemeier; Karsten Parczyk; Yuki Nishino; Martin R Schneider
Antiprogestin-progesterone interactions.
Cancer treatment and research 1996;83():191-212.
1995: P Diel; A Walter; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung; R Knauthe
Identification of estrogen regulated genes in Fe33 rat hepatoma cells by differential display polymerase chain reaction and their hormonal regulation in rat liver and uterus.
The Journal of steroid biochemistry and molecular biology 1995;55(3-4):363-73.
1995: P Muhn; UU Fuhrmann; Karl-Heinrich Fritzemeier; R Krattenmacher; E Schillinger
Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity.
Annals of the New York Academy of Sciences 1995;761():311-35.
1995: Kristof Chwalisz; K Stöckemann; UU Fuhrmann; Karl-Heinrich Fritzemeier; A Einspanier; Robert E Garfield
Mechanism of action of antiprogestins in the pregnant uterus.
Annals of the New York Academy of Sciences 1995;761():202-23.
1995: W Kuhnz; Karl-Heinrich Fritzemeier; Christa Hegele-Hartung; R Krattenmacher
Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor.
Contraception 1995;51(2):131-9.
1995: UU Fuhrmann; E P Slater; Karl-Heinrich Fritzemeier
Characterization of the novel progestin gestodene by receptor binding studies and transactivation assays.
Contraception 1995;51(1):45-52.
1994: E Ottow; S Beier; W Elger; Karl-Heinrich Fritzemeier; G Neef; R Wiechert
Synthesis and biological testing of 4'-(dimethylamino)-17 beta-hydroxy-17 alpha-(1-propynyl)benzo[12,12a]-11 alpha,18-cyclo-12a,12b-dihomo-13 alpha-estr-4-en-3-one: an interesting RU 38 486 analog.
Steroids 1994;59(3):185-9.
1994: R Krattenmacher; R Knauthe; Karsten Parczyk; A Walker; U Hilgenfeldt; Karl-Heinrich Fritzemeier
Estrogen action on hepatic synthesis of angiotensinogen and IGF-I: direct and indirect estrogen effects.
The Journal of steroid biochemistry and molecular biology 1994;48(2-3):207-14.
1991: Kristof Chwalisz; Christa Hegele-Hartung; Karl-Heinrich Fritzemeier; Henning M Beier; W Elger
Inhibition of the estradiol-mediated endometrial gland formation by the antigestagen onapristone in rabbits: relationship to uterine estrogen receptors.
Endocrinology 1991;129(1):312-22.