ER Froesch

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Bianda T; Zapf J; Froesch E R; Schmid C
Insulin-like growth factor-I lowers fasting and postprandial triglyceride levels without affecting chylomicron clearance in healthy men.
Frystyk J; Hussain M; Skjaerbaek C; Pørksen N; Froesch E R; Orskov H
The pharmacokinetics of free insulin-like growth factor-I in healthy subjects.
Donath M Y; Sütsch G; Yan X W; Piva B; Brunner H P; Glatz Y; Zapf J; Follath F; Froesch E R; Kiowski W
Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure.

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1999: Bianda T; Zapf J; Froesch E R; Schmid C
Insulin-like growth factor-I lowers fasting and postprandial triglyceride levels without affecting chylomicron clearance in healthy men.
Journal of internal medicine 1999;245(5):455-62.
1999: Frystyk J; Hussain M; Skjaerbaek C; Pørksen N; Froesch E R; Orskov H
The pharmacokinetics of free insulin-like growth factor-I in healthy subjects.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1999;9(2):150-6.
1998: Donath M Y; Sütsch G; Yan X W; Piva B; Brunner H P; Glatz Y; Zapf J; Follath F; Froesch E R; Kiowski W
Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure.
The Journal of clinical endocrinology and metabolism 1998;83(9):3177-83.
1998: Donath M Y; Zierhut W; Gosteli-Peter M A; Hauri C; Froesch E R; Zapf J
Effects of IGF-I on cardiac growth and expression of mRNAs coding for cardiac proteins after induction of heart hypertrophy in the rat.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(1):109-17.
1998: Donath M Y; Froesch E R; Zapf J
Insulin-like growth factor I and cardiac performance in heart failure.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8 Suppl B():167-70.
1998: Bianda T; Glatz Y; Bouillon R; Froesch E R; Schmid C
Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults.
The Journal of clinical endocrinology and metabolism 1998;83(1):81-7.
1997: Bianda T; Froesch E R; Schmid C
Growth hormone and serum leptin in GH-deficient adults.
Clinical endocrinology 1997;47(4):502-3.
1997: Donath M Y; Gosteli-Peter M A; Hauri C; Froesch E R; Zapf J
Insulin-like growth factor-I stimulates myofibrillar genes and modulates atrial natriuretic factor mRNA in rat heart.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(3):309-15.
1997: Frystyk J; Hussain M; Skjaerbaek C; Schmitz O; Christiansen J S; Froesch E R; Orskov H
Serum free IGF-I during a hyperinsulinemic clamp following 3 days of administration of IGF-I vs. saline.
The American journal of physiology 1997;273(3 Pt 1):E507-13.
1997: Pørksen N; Hussain M A; Bianda T L; Nyholm B; Christiansen J S; Butler P C; Veldhuis J D; Froesch E R; Schmitz O
IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates.
The American journal of physiology 1997;272(3 Pt 1):E352-8.
1997: Bianda T L; Glatz Y; Boeni-Schnetzler M; Froesch E R; Schmid C
Effects of growth hormone (GH) and insulin-like growth factor-I on serum leptin in GH-deficient adults.
Diabetologia 1997;40(3):363-4.
1997: Bianda T; Hussain M A; Glatz Y; Bouillon R; Froesch E R; Schmid C
Effects of short-term insulin-like growth factor-I or growth hormone treatment on bone turnover, renal phosphate reabsorption and 1,25 dihydroxyvitamin D3 production in healthy man.
Journal of internal medicine 1997;241(2):143-50.
1996: Schmid C; Schläpfer I; Gosteli-Peter M A; Froesch E R; Zapf J
Effects and fate of human IGF-binding protein-5 in rat osteoblast cultures.
The American journal of physiology 1996;271(6 Pt 1):E1029-35.
1996: Froesch E R; Hussain M A; Schmid C; Zapf J
Insulin-like growth factor I: physiology, metabolic effects and clinical uses.
Diabetes/metabolism reviews 1996;12(3):195-215.
1996: Moritz W; Böni-Schnetzler M; Stevens W; Froesch E R; Levy J R
In-frame exon 2 deletion in insulin receptor RNA in a family with extreme insulin resistance in association with defective insulin binding: a case report.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(3):357-63.
1996: Bianda T L; Hussain M A; Keller A; Glatz Y; Schmitz O; Christiansen J S; Alberti K G; Froesch E R
Insulin-like growth factor-I in man enhances lipid mobilization and oxidation induced by a growth hormone pulse.
Diabetologia 1996;39(8):961-9.
1996: Schmid C; Schläpfer I; Gosteli-Peter M A; Hauri C; Froesch E R; Zapf J
1 alpha,25-dihydroxyvitamin D3 increases IGF binding protein-5 expression in cultured osteoblasts.
FEBS letters 1996;392(1):21-4.
1996: Böni-Schnetzler M; Gosteli-Peter M A; Moritz W; Froesch E R; Zapf J
Reduced ob mRNA in hypophysectomised rats is not restored by growth hormone (GH), but further suppressed by exogenously administered insulin-like growth factor (IGF) I.
Biochemical and biophysical research communications 1996;225(1):296-301.
1996: Froesch E R; Bianda T; Hussain M A
Insulin-like growth factor-I in the therapy of non-insulin-dependent diabetes mellitus and insulin resistance.
Diabetes & metabolism 1996;22(4):261-7.
1996: Hussain M A; Schmitz O; Jorgensen J O; Christiansen J S; Weeke J; Schmid C; Froesch E R
Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans: comparison with growth hormone.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(5):563-7.
1996: Hussain M A; Schmitz O; Christiansen J S; Christensen N J; Alberti K G; Froesch E R
IGF-I alters skeletal muscle substrate metabolism and blunts recovery from insulin-induced hypoglycemia.
The American journal of physiology 1996;270(4 Pt 1):E545-51.
1996: Rutishauser J; Böni-Schnetzler M; Böni J; Wichmann W; Huisman T; Vallotton M B; Froesch E R
A novel point mutation in the translation initiation codon of the pre-pro-vasopressin-neurophysin II gene: cosegregation with morphological abnormalities and clinical symptoms in autosomal dominant neurohypophyseal diabetes insipidus.
The Journal of clinical endocrinology and metabolism 1996;81(1):192-8.
1995: Schmid C; Schläpfer I; Keller A; Waldvogel M; Froesch E R; Zapf J
Effects of insulin-like growth factor (IGF) binding proteins (BPs) -3 and -6 on DNA synthesis of rat osteoblasts: further evidence for a role of auto-/paracrine IGF I but not IGF II in stimulating osteoblast growth.
Biochemical and biophysical research communications 1995;212(1):242-8.
1995: Zapf J; Hauri C; Futo E; Hussain M; Rutishauser J; Maack C A; Froesch E R
Intravenously injected insulin-like growth factor (IGF) I/IGF binding protein-3 complex exerts insulin-like effects in hypophysectomized, but not in normal rats.
The Journal of clinical investigation 1995;95(1):179-86.
1995: Schmid C; Schläpfer I; Gosteli-Peter M A; Froesch E R; Zapf J
Expression, effects, and fate of IGFBP-5 are different in normal and malignant osteoblastic cells.
Progress in growth factor research 1995;6(2-4):167-73.
1994: Gosteli-Peter M A; Winterhalter K H; Schmid C; Froesch E R; Zapf J
Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone.
Endocrinology 1994;135(6):2558-67.
1994: Hussain M A; Schmitz O; Mengel A; Glatz Y; Christiansen J S; Zapf J; Froesch E R
Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.
The Journal of clinical investigation 1994;94(3):1126-33.
1994: Moritz W; Froesch E R; Böni-Schnetzler M
Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient.
FEBS letters 1994;351(2):276-80.
1994: Zenobi P D; Glatz Y; Keller A; Graf S; Jaeggi-Groisman S E; Riesen W F; Schoenle E J; Froesch E R
Beneficial metabolic effects of insulin-like growth factor I in patients with severe insulin-resistant diabetes type A.
European journal of endocrinology / European Federation of Endocrine Societies 1994;131(3):251-7.
1994: Froesch E R; Hussain M
Recombinant human insulin-like growth factor-I: a therapeutic challenge for diabetes mellitus.
Diabetologia 1994;37 Suppl 2():S179-85.
1994: Schmid C; Schläpfer I; Peter M; Böni-Schnetzler M; Schwander J; Zapf J; Froesch E R
Growth hormone and parathyroid hormone stimulate IGFBP-3 in rat osteoblasts.
The American journal of physiology 1994;267(2 Pt 1):E226-33.
1994: Binz K; Schmid C; Bouillon R; Froesch E R; Jürgensen K; Hunziker E B
Interactions of insulin-like growth factor I with dexamethasone on trabecular bone density and mineral metabolism in rats.
European journal of endocrinology / European Federation of Endocrine Societies 1994;130(4):387-93.
1994: Donath M Y; Zapf J; Eppenberger-Eberhardt M; Froesch E R; Eppenberger H M
Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1686-90.
1994: Froesch E R; Zenobi P D; Hussain M
Metabolic and therapeutic effects of insulin-like growth factor I.
Hormone research 1994;42(1-2):66-71.
1993: Froesch E R; Hussain M
Therapeutic potential of rhIGF-I in diabetes and conditions of insulin resistance.
Journal of internal medicine 1993;234(6):561-70.
1993: Peter M A; Winterhalter K H; Böni-Schnetzler M; Froesch E R; Zapf J
Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by growth hormone in rat white adipose tissue.
Endocrinology 1993;133(6):2624-31.
1993: Hussain M A; Schmitz O; Mengel A; Keller A; Christiansen J S; Zapf J; Froesch E R
Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans.
The Journal of clinical investigation 1993;92(5):2249-56.
1993: Rutishauser J; Schmid C; Hauri C; Froesch E R; Zapf J
Growth hormone, but not insulin-like growth factor I, induces a serum protease activity for insulin-like growth factor binding protein-3 in hypophysectomized rats in vivo.
FEBS letters 1993;334(1):23-6.
1993: Eriksson U; Duc G; Froesch E R; Zapf J
Insulin-like growth factors (IGF) I and II and IGF binding proteins (IGFBPs) in human colostrum/transitory milk during the first week postpartum: comparison with neonatal and maternal serum.
Biochemical and biophysical research communications 1993;196(1):267-73.
1993: Zenobi P D; Holzmann P; Glatz Y; Riesen W F; Froesch E R
Improvement of lipid profile in type 2 (non-insulin-dependent) diabetes mellitus by insulin-like growth factor I.
Diabetologia 1993;36(5):465-9.
1993: Schmid C; Schläpfer I; Waldvogel M; Peter M; Zapf J; Froesch E R
Production of IGFBP-3 by connective tissue and endothelial cells.
Growth regulation 1993;3(1):65-7.
1992: Zenobi P D; Jaeggi-Groisman S E; Riesen W F; Røder M E; Froesch E R
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.
The Journal of clinical investigation 1992;90(6):2234-41.
1992: Zapf J; Futo E; Peter M; Froesch E R
Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?
The Journal of clinical investigation 1992;90(6):2574-84.
1992: Schmid C; Schläpfer I; Waldvogel M; Zapf J; Froesch E R
Prostaglandin E2 stimulates synthesis of insulin-like growth factor binding protein-3 in rat bone cells in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(10):1157-63.
1992: Zenobi P D; Graf S; Ursprung H; Froesch E R
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion.
The Journal of clinical investigation 1992;89(6):1908-13.
1992: Schmid C; Schläpfer I; Waldvogel M; Meier P J; Schwander J; Böni-Schnetzler M; Zapf J; Froesch E R
Differential regulation of insulin-like growth factor binding protein (IGFBP)-2 mRNA in liver and bone cells by insulin and retinoic acid in vitro.
FEBS letters 1992;303(2-3):205-9.
1992: Schmid C; Schläpfer I; Futo E; Waldvogel M; Schwander J; Zapf J; Froesch E R
Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro.
Acta endocrinologica 1992;126(5):467-73.
1992: Jaeggi-Groisman S E; Kiess W; Christomanou H; Kessler U; Froesch E R
Insulin-like growth factors in lysosomal storage disease.
European journal of pediatrics 1992;151(1):29-31.
1991: Schoenle E J; Zenobi P D; Torresani T; Werder E A; Zachmann M; Froesch E R
Recombinant human insulin-like growth factor I (rhIGF I) reduces hyperglycaemia in patients with extreme insulin resistance.
Diabetologia 1991;34(9):675-9.
1991: Schmid C; Rutishauser J; Schläpfer I; Froesch E R; Zapf J
Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: control of IGF signalling to bone cells by IGFBP-3-specific proteolysis?
Biochemical and biophysical research communications 1991;179(1):579-85.
1991: Böni-Schnetzler M; Schmid C; Meier P J; Froesch E R
Insulin regulates insulin-like growth factor I mRNA in rat hepatocytes.
The American journal of physiology 1991;260(6 Pt 1):E846-51.
1991: Guler H P; Wettstein K; Schurr W; Zapf J; Froesch E R
Recombinant human insulin-like growth factor I: effects in normal subjects and implications for use in patients.
Advances in experimental medicine and biology 1991;293():97-104.
1990: Jaeggi-Groisman S E; Keller S; Zimmerli B; Meier P J; Froesch E R
Polar surface distribution of type II insulin-like growth factor receptor in rat hepatocytes.
Molecular and cellular endocrinology 1990;74(1):69-74.
1990: Böni-Schnetzler M; Schmid C; Mary J L; Zimmerli B; Meier P J; Zapf J; Schwander J; Froesch E R
Insulin regulates the expression of the insulin-like growth factor binding protein 2 mRNA in rat hepatocytes.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1320-6.
1990: Zapf J; Schmid C; Guler H P; Waldvogel M; Hauri C; Futo E; Hossenlopp P; Binoux M; Froesch E R
Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.
The Journal of clinical investigation 1990;86(3):952-61.
1990: Zapf J; Kiefer M; Merryweather J; Musiarz F; Bauer D; Born W; Fischer J A; Froesch E R
Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.
The Journal of biological chemistry 1990;265(25):14892-8.
1990: Binz K; Joller P; Froesch P; Binz H; Zapf J; Froesch E R
Repopulation of the atrophied thymus in diabetic rats by insulin-like growth factor I.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3690-4.
1990: Guler H P; Schmid C; Zapf J; Froesch E R
Effects of insulin-like growth factor I in man.
Acta paediatrica Scandinavica. Supplement 1990;367():52-4.
1989: Guler H P; Zapf J; Schmid C; Froesch E R
Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates.
Acta endocrinologica 1989;121(6):753-8.
1989: Ernst M; Schmid C; Froesch E R
Phenol red mimics biological actions of estradiol: enhancement of osteoblast proliferation in vitro and of type I collagen gene expression in bone and uterus of rats in vivo.
Journal of steroid biochemistry 1989;33(5):907-14.
1989: Binz K; Zapf J; Froesch E R
The role of insulin-like growth factor I in growth of diabetic rats.
Acta endocrinologica 1989;121(5):628-32.
1989: Guler H P; Binz K; Eigenmann E; Jäggi S; Zimmermann D; Zapf J; Froesch E R
Small stature and insulin-like growth factors: prolonged treatment of mini-poodles with recombinant human insulin-like growth factor I.
Acta endocrinologica 1989;121(3):456-64.
1989: Keller S; Schmid C; Zapf J; Froesch E R
Inhibition of insulin degradation by insulin-like growth factors I and II in human hepatoma (HepG2) cells.
Acta endocrinologica 1989;121(2):279-85.
1989: Böni-Schnetzler M; Binz K; Mary J L; Schmid C; Schwander J; Froesch E R
Regulation of hepatic expression of IGF I and fetal IGF binding protein mRNA in streptozotocin-diabetic rats.
FEBS letters 1989;251(1-2):253-6.
1989: Zapf J; Hauri C; Waldvogel M; Futo E; Häsler H; Binz K; Guler H P; Schmid C; Froesch E R
Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3813-7.
1989: Guler H P; Schmid C; Zapf J; Froesch E R
Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2868-72.
1988: Zapf J; Born W; Chang J Y; James P; Froesch E R; Fischer J A
Isolation and NH2-terminal amino acid sequences of rat serum carrier proteins for insulin-like growth factors.
Biochemical and biophysical research communications 1988;156(3):1187-94.
1988: Kurtz A; Zapf J; Eckardt K U; Clemons G; Froesch E R; Bauer C
Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7825-9.
1988: Guler H P; Zapf J; Scheiwiller E; Froesch E R
Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4889-93.
1988: Ernst M; Schmid C; Froesch E R
Enhanced osteoblast proliferation and collagen gene expression by estradiol.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2307-10.
1988: Zenobi P D; Guler H P; Zapf J; Froesch E R
Insulin-like growth factors in the Göttinger miniature-pig.
Acta endocrinologica 1988;117(3):343-52.
1988: Ernst M; Froesch E R
Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I.
Biochemical and biophysical research communications 1988;151(1):142-7.
1986: Zapf J; Hauri C; Waldvogel M; Froesch E R
Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats.
The Journal of clinical investigation 1986;77(6):1768-75.
1982: Schoenle E; Zapf J; Humbel R E; Froesch E R
Insulin-like growth factor I stimulates growth in hypophysectomized rats.
Nature 1982;296(5854):252-3.

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