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ER Froesch

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Tarcisio Bianda; Jürgen Zapf; ER Froesch; Christoph Schmid
Insulin-like growth factor-I lowers fasting and postprandial triglyceride levels without affecting chylomicron clearance in healthy men.
Jan Frystyk; Mehboob A Hussain; Christian Skjaerbaek; Niels Pørksen; ER Froesch; Hans Orskov
The pharmacokinetics of free insulin-like growth factor-I in healthy subjects.
Marc Y Donath; Gabor Sütsch; XW Yan; B Piva; HP Brunner; Y Glatz; Jürgen Zapf; F Follath; ER Froesch; W Kiowski
Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure.

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1999: Tarcisio Bianda; Jürgen Zapf; ER Froesch; Christoph Schmid
Insulin-like growth factor-I lowers fasting and postprandial triglyceride levels without affecting chylomicron clearance in healthy men.
Journal of internal medicine 1999;245(5):455-62.
1999: Jan Frystyk; Mehboob A Hussain; Christian Skjaerbaek; Niels Pørksen; ER Froesch; Hans Orskov
The pharmacokinetics of free insulin-like growth factor-I in healthy subjects.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1999;9(2):150-6.
1998: Marc Y Donath; Gabor Sütsch; XW Yan; B Piva; HP Brunner; Y Glatz; Jürgen Zapf; F Follath; ER Froesch; W Kiowski
Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure.
The Journal of clinical endocrinology and metabolism 1998;83(9):3177-83.
1998: Marc Y Donath; W Zierhut; Martina Gosteli-Peter; C Hauri; ER Froesch; Jürgen Zapf
Effects of IGF-I on cardiac growth and expression of mRNAs coding for cardiac proteins after induction of heart hypertrophy in the rat.
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(1):109-17.
1998: Marc Y Donath; ER Froesch; Jürgen Zapf
Insulin-like growth factor I and cardiac performance in heart failure.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1998;8 Suppl B():167-70.
1998: Tarcisio Bianda; Y Glatz; R Bouillon; ER Froesch; Christoph Schmid
Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults.
The Journal of clinical endocrinology and metabolism 1998;83(1):81-7.
1997: Tarcisio Bianda; ER Froesch; Christoph Schmid
Growth hormone and serum leptin in GH-deficient adults.
Clinical endocrinology 1997;47(4):502-3.
1997: Marc Y Donath; Martina Gosteli-Peter; C Hauri; ER Froesch; Jürgen Zapf
Insulin-like growth factor-I stimulates myofibrillar genes and modulates atrial natriuretic factor mRNA in rat heart.
European journal of endocrinology / European Federation of Endocrine Societies 1997;137(3):309-15.
1997: Jan Frystyk; Mehboob A Hussain; Christian Skjaerbaek; Ole Schmitz; Jens Sandahl Christiansen; ER Froesch; Hans Orskov
Serum free IGF-I during a hyperinsulinemic clamp following 3 days of administration of IGF-I vs. saline.
The American journal of physiology 1997;273(3 Pt 1):E507-13.
1997: Niels Pørksen; Mehboob A Hussain; Tarcisio Bianda; Birgit Nyholm; Jens Sandahl Christiansen; Peter C Butler; Johannes D Veldhuis; ER Froesch; Ole Schmitz
IGF-I inhibits burst mass of pulsatile insulin secretion at supraphysiological and low IGF-I infusion rates.
The American journal of physiology 1997;272(3 Pt 1):E352-8.
1997: Tarcisio Bianda; Y Glatz; M Boeni-Schnetzler; ER Froesch; Christoph Schmid
Effects of growth hormone (GH) and insulin-like growth factor-I on serum leptin in GH-deficient adults.
Diabetologia 1997;40(3):363-4.
1997: Tarcisio Bianda; Mehboob A Hussain; Y Glatz; R Bouillon; ER Froesch; Christoph Schmid
Effects of short-term insulin-like growth factor-I or growth hormone treatment on bone turnover, renal phosphate reabsorption and 1,25 dihydroxyvitamin D3 production in healthy man.
Journal of internal medicine 1997;241(2):143-50.
1996: Christoph Schmid; I Schläpfer; Martina Gosteli-Peter; ER Froesch; Jürgen Zapf
Effects and fate of human IGF-binding protein-5 in rat osteoblast cultures.
The American journal of physiology 1996;271(6 Pt 1):E1029-35.
1996: ER Froesch; Mehboob A Hussain; Christoph Schmid; Jürgen Zapf
Insulin-like growth factor I: physiology, metabolic effects and clinical uses.
Diabetes/metabolism reviews 1996;12(3):195-215.
1996: W Moritz; M Böni-Schnetzler; W Stevens; ER Froesch; James R Levy
In-frame exon 2 deletion in insulin receptor RNA in a family with extreme insulin resistance in association with defective insulin binding: a case report.
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(3):357-63.
1996: Christoph Schmid; I Schläpfer; Martina Gosteli-Peter; C Hauri; ER Froesch; Jürgen Zapf
1 alpha,25-dihydroxyvitamin D3 increases IGF binding protein-5 expression in cultured osteoblasts.
FEBS letters 1996;392(1):21-4.
1996: M Böni-Schnetzler; Martina Gosteli-Peter; W Moritz; ER Froesch; Jürgen Zapf
Reduced ob mRNA in hypophysectomised rats is not restored by growth hormone (GH), but further suppressed by exogenously administered insulin-like growth factor (IGF) I.
Biochemical and biophysical research communications 1996;225(1):296-301.
1996: Tarcisio Bianda; Mehboob A Hussain; A Keller; Y Glatz; O Schmitz; J S Christiansen; K G Alberti; ER Froesch
Insulin-like growth factor-I in man enhances lipid mobilization and oxidation induced by a growth hormone pulse.
Diabetologia 1996;39(8):961-9.
1996: ER Froesch; Tarcisio Bianda; Mehboob A Hussain
Insulin-like growth factor-I in the therapy of non-insulin-dependent diabetes mellitus and insulin resistance.
Diabetes & metabolism 1996;22(4):261-7.
1996: Mehboob A Hussain; Ole Schmitz; J O Jorgensen; J S Christiansen; J Weeke; Christoph Schmid; ER Froesch
Insulin-like growth factor I alters peripheral thyroid hormone metabolism in humans: comparison with growth hormone.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(5):563-7.
1996: Mehboob A Hussain; O Schmitz; J S Christiansen; N J Christensen; K G Alberti; ER Froesch
IGF-I alters skeletal muscle substrate metabolism and blunts recovery from insulin-induced hypoglycemia.
The American journal of physiology 1996;270(4 Pt 1):E545-51.
1996: J Rutishauser; M Böni-Schnetzler; J Böni; W Wichmann; T Huisman; Michel B Vallotton; ER Froesch
A novel point mutation in the translation initiation codon of the pre-pro-vasopressin-neurophysin II gene: cosegregation with morphological abnormalities and clinical symptoms in autosomal dominant neurohypophyseal diabetes insipidus.
The Journal of clinical endocrinology and metabolism 1996;81(1):192-8.
1995: Christoph Schmid; I Schläpfer; A Keller; M Waldvogel; ER Froesch; Jürgen Zapf
Effects of insulin-like growth factor (IGF) binding proteins (BPs) -3 and -6 on DNA synthesis of rat osteoblasts: further evidence for a role of auto-/paracrine IGF I but not IGF II in stimulating osteoblast growth.
Biochemical and biophysical research communications 1995;212(1):242-8.
1995: Christoph Schmid; I Schläpfer; Martina Gosteli-Peter; ER Froesch; Jürgen Zapf
Expression, effects, and fate of IGFBP-5 are different in normal and malignant osteoblastic cells.
Progress in growth factor research 1995;6(2-4):167-73.
1995: Jürgen Zapf; C Hauri; E Futo; Mehboob A Hussain; J Rutishauser; C A Maack; ER Froesch
Intravenously injected insulin-like growth factor (IGF) I/IGF binding protein-3 complex exerts insulin-like effects in hypophysectomized, but not in normal rats.
The Journal of clinical investigation 1995;95(1):179-86.
1994: Martina Gosteli-Peter; K H Winterhalter; Christoph Schmid; ER Froesch; Jürgen Zapf
Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone.
Endocrinology 1994;135(6):2558-67.
1994: W Moritz; ER Froesch; M Böni-Schnetzler
Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient.
FEBS letters 1994;351(2):276-80.
1994: Mehboob A Hussain; O Schmitz; A Mengel; Y Glatz; J S Christiansen; Jürgen Zapf; ER Froesch
Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.
The Journal of clinical investigation 1994;94(3):1126-33.
1994: P D Zenobi; Y Glatz; A Keller; S Graf; S E Jaeggi-Groisman; W F Riesen; E J Schoenle; ER Froesch
Beneficial metabolic effects of insulin-like growth factor I in patients with severe insulin-resistant diabetes type A.
European journal of endocrinology / European Federation of Endocrine Societies 1994;131(3):251-7.
1994: ER Froesch; Mehboob A Hussain
Recombinant human insulin-like growth factor-I: a therapeutic challenge for diabetes mellitus.
Diabetologia 1994;37 Suppl 2():S179-85.
1994: Christoph Schmid; I Schläpfer; M Peter; M Böni-Schnetzler; J Schwander; Jürgen Zapf; ER Froesch
Growth hormone and parathyroid hormone stimulate IGFBP-3 in rat osteoblasts.
The American journal of physiology 1994;267(2 Pt 1):E226-33.
1994: K Binz; Christoph Schmid; R Bouillon; ER Froesch; K Jürgensen; E B Hunziker
Interactions of insulin-like growth factor I with dexamethasone on trabecular bone density and mineral metabolism in rats.
European journal of endocrinology / European Federation of Endocrine Societies 1994;130(4):387-93.
1994: Marc Y Donath; Jürgen Zapf; M Eppenberger-Eberhardt; ER Froesch; Hans M Eppenberger
Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1686-90.
1994: ER Froesch; P D Zenobi; Mehboob A Hussain
Metabolic and therapeutic effects of insulin-like growth factor I.
Hormone research 1994;42(1-2):66-71.
1993: ER Froesch; Mehboob A Hussain
Therapeutic potential of rhIGF-I in diabetes and conditions of insulin resistance.
Journal of internal medicine 1993;234(6):561-70.
1993: M A Peter; K H Winterhalter; M Böni-Schnetzler; ER Froesch; Jürgen Zapf
Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by growth hormone in rat white adipose tissue.
Endocrinology 1993;133(6):2624-31.
1993: J Rutishauser; Christoph Schmid; C Hauri; ER Froesch; Jürgen Zapf
Growth hormone, but not insulin-like growth factor I, induces a serum protease activity for insulin-like growth factor binding protein-3 in hypophysectomized rats in vivo.
FEBS letters 1993;334(1):23-6.
1993: Mehboob A Hussain; O Schmitz; A Mengel; A Keller; J S Christiansen; Jürgen Zapf; ER Froesch
Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans.
The Journal of clinical investigation 1993;92(5):2249-56.
1993: U Eriksson; G Duc; ER Froesch; Jürgen Zapf
Insulin-like growth factors (IGF) I and II and IGF binding proteins (IGFBPs) in human colostrum/transitory milk during the first week postpartum: comparison with neonatal and maternal serum.
Biochemical and biophysical research communications 1993;196(1):267-73.
1993: P D Zenobi; P Holzmann; Y Glatz; W F Riesen; ER Froesch
Improvement of lipid profile in type 2 (non-insulin-dependent) diabetes mellitus by insulin-like growth factor I.
Diabetologia 1993;36(5):465-9.
1993: Christoph Schmid; I Schläpfer; M Waldvogel; M Peter; Jürgen Zapf; ER Froesch
Production of IGFBP-3 by connective tissue and endothelial cells.
Growth regulation 1993;3(1):65-7.
1992: P D Zenobi; S E Jaeggi-Groisman; W F Riesen; M E Røder; ER Froesch
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.
The Journal of clinical investigation 1992;90(6):2234-41.
1992: Jürgen Zapf; E Futo; M Peter; ER Froesch
Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?
The Journal of clinical investigation 1992;90(6):2574-84.
1992: Christoph Schmid; I Schläpfer; M Waldvogel; Jürgen Zapf; ER Froesch
Prostaglandin E2 stimulates synthesis of insulin-like growth factor binding protein-3 in rat bone cells in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(10):1157-63.
1992: P D Zenobi; S Graf; H Ursprung; ER Froesch
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion.
The Journal of clinical investigation 1992;89(6):1908-13.
1992: Christoph Schmid; I Schläpfer; M Waldvogel; Peter Meier; J Schwander; M Böni-Schnetzler; Jürgen Zapf; ER Froesch
Differential regulation of insulin-like growth factor binding protein (IGFBP)-2 mRNA in liver and bone cells by insulin and retinoic acid in vitro.
FEBS letters 1992;303(2-3):205-9.
1992: Christoph Schmid; I Schläpfer; E Futo; M Waldvogel; J Schwander; Jürgen Zapf; ER Froesch
Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro.
Acta endocrinologica 1992;126(5):467-73.
1992: S E Jaeggi-Groisman; Wieland Kiess; H Christomanou; U Kessler; ER Froesch
Insulin-like growth factors in lysosomal storage disease.
European journal of pediatrics 1992;151(1):29-31.
1991: E J Schoenle; P D Zenobi; Toni Torresani; E A Werder; M Zachmann; ER Froesch
Recombinant human insulin-like growth factor I (rhIGF I) reduces hyperglycaemia in patients with extreme insulin resistance.
Diabetologia 1991;34(9):675-9.
1991: Christoph Schmid; J Rutishauser; I Schläpfer; ER Froesch; Jürgen Zapf
Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: control of IGF signalling to bone cells by IGFBP-3-specific proteolysis?
Biochemical and biophysical research communications 1991;179(1):579-85.
1991: M Böni-Schnetzler; Christoph Schmid; Peter Meier; ER Froesch
Insulin regulates insulin-like growth factor I mRNA in rat hepatocytes.
The American journal of physiology 1991;260(6 Pt 1):E846-51.
1991: H P Guler; K Wettstein; W Schurr; Jürgen Zapf; ER Froesch
Recombinant human insulin-like growth factor I: effects in normal subjects and implications for use in patients.
Advances in experimental medicine and biology 1991;293():97-104.
1990: S E Jaeggi-Groisman; S Keller; B Zimmerli; Peter Meier; ER Froesch
Polar surface distribution of type II insulin-like growth factor receptor in rat hepatocytes.
Molecular and cellular endocrinology 1990;74(1):69-74.
1990: Jürgen Zapf; M Kiefer; J Merryweather; F Musiarz; D Bauer; W Born; J A Fischer; ER Froesch
Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.
The Journal of biological chemistry 1990;265(25):14892-8.
1990: M Böni-Schnetzler; Christoph Schmid; J L Mary; B Zimmerli; Peter Meier; Jürgen Zapf; J Schwander; ER Froesch
Insulin regulates the expression of the insulin-like growth factor binding protein 2 mRNA in rat hepatocytes.
Molecular endocrinology (Baltimore, Md.) 1990;4(9):1320-6.
1990: Jürgen Zapf; Christoph Schmid; H P Guler; M Waldvogel; C Hauri; E Futo; P Hossenlopp; Michel Binoux; ER Froesch
Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.
The Journal of clinical investigation 1990;86(3):952-61.
1990: K Binz; P Joller; P Froesch; H Binz; Jürgen Zapf; ER Froesch
Repopulation of the atrophied thymus in diabetic rats by insulin-like growth factor I.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3690-4.
1990: H P Guler; Christoph Schmid; Jürgen Zapf; ER Froesch
Effects of insulin-like growth factor I in man.
Acta paediatrica Scandinavica. Supplement 1990;367():52-4.
1989: H P Guler; Jürgen Zapf; Christoph Schmid; ER Froesch
Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates.
Acta endocrinologica 1989;121(6):753-8.
1989: M Ernst; Christoph Schmid; ER Froesch
Phenol red mimics biological actions of estradiol: enhancement of osteoblast proliferation in vitro and of type I collagen gene expression in bone and uterus of rats in vivo.
Journal of steroid biochemistry 1989;33(5):907-14.
1989: K Binz; Jürgen Zapf; ER Froesch
The role of insulin-like growth factor I in growth of diabetic rats.
Acta endocrinologica 1989;121(5):628-32.
1989: H P Guler; K Binz; E Eigenmann; S Jäggi; D Zimmermann; Jürgen Zapf; ER Froesch
Small stature and insulin-like growth factors: prolonged treatment of mini-poodles with recombinant human insulin-like growth factor I.
Acta endocrinologica 1989;121(3):456-64.
1989: S Keller; Christoph Schmid; Jürgen Zapf; ER Froesch
Inhibition of insulin degradation by insulin-like growth factors I and II in human hepatoma (HepG2) cells.
Acta endocrinologica 1989;121(2):279-85.
1989: M Böni-Schnetzler; K Binz; J L Mary; Christoph Schmid; J Schwander; ER Froesch
Regulation of hepatic expression of IGF I and fetal IGF binding protein mRNA in streptozotocin-diabetic rats.
FEBS letters 1989;251(1-2):253-6.
1989: Jürgen Zapf; C Hauri; M Waldvogel; E Futo; H Häsler; K Binz; H P Guler; Christoph Schmid; ER Froesch
Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3813-7.
1989: H P Guler; Christoph Schmid; Jürgen Zapf; ER Froesch
Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2868-72.
1988: Jürgen Zapf; W Born; J Y Chang; P James; ER Froesch; J A Fischer
Isolation and NH2-terminal amino acid sequences of rat serum carrier proteins for insulin-like growth factors.
Biochemical and biophysical research communications 1988;156(3):1187-94.
1988: A Kurtz; J Zapf; K U Eckardt; G Clemons; ER Froesch; Christian Bauer
Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7825-9.
1988: H P Guler; Jürgen Zapf; E Scheiwiller; ER Froesch
Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4889-93.
1988: M Ernst; Christoph Schmid; ER Froesch
Enhanced osteoblast proliferation and collagen gene expression by estradiol.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(7):2307-10.
1988: P D Zenobi; H P Guler; Jürgen Zapf; ER Froesch
Insulin-like growth factors in the Göttinger miniature-pig.
Acta endocrinologica 1988;117(3):343-52.
1988: M Ernst; ER Froesch
Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I.
Biochemical and biophysical research communications 1988;151(1):142-7.
1986: Jürgen Zapf; C Hauri; M Waldvogel; ER Froesch
Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats.
The Journal of clinical investigation 1986;77(6):1768-75.
1982: E Schoenle; J Zapf; R E Humbel; ER Froesch
Insulin-like growth factor I stimulates growth in hypophysectomized rats.
Nature 1982;296(5854):252-3.