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Wolfgang Froestl

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Wolfgang Froestl; Andrea Pfeifer; Andreas Muhs
Cognitive enhancers (nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. disease-modifying drugs.
Wolfgang Froestl; Andreas Muhs; Andrea Pfeifer
Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes.
Heiko Kroth; Hilal A Lashuel; Sophie Lohmann; María Pilar López-Deber; Oskar Adolfsson; Annalisa Ansaloni; Wolfgang Froestl; Valérie Giriens; Asad Jan; Luitgard Nagel-Steger; Paolo Paganetti; Andrea Pfeifer; Maria Pihlgren; Nasrollah Rezaei-Ghaleh; Thomas Schrader; Nampally Sreenivasachary; Yvan Varisco; Dieter Willbold; Markus Zweckstetter; Andreas Muhs
Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.

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All Publications

2013: Wolfgang Froestl; Andrea Pfeifer; Andreas Muhs
Cognitive enhancers (nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. disease-modifying drugs.
Journal of Alzheimer's disease : JAD 2013;34(1):1-114.
2013: Wolfgang Froestl; Andreas Muhs; Andrea Pfeifer
Cognitive enhancers (nootropics). Part 2: drugs interacting with enzymes.
Journal of Alzheimer's disease : JAD 2013;33(3):547-658.
2012: Heiko Kroth; Hilal A Lashuel; Sophie Lohmann; María Pilar López-Deber; Oskar Adolfsson; Annalisa Ansaloni; Wolfgang Froestl; Valérie Giriens; Asad Jan; Luitgard Nagel-Steger; Paolo Paganetti; Andrea Pfeifer; Maria Pihlgren; Nasrollah Rezaei-Ghaleh; Thomas Schrader; Nampally Sreenivasachary; Yvan Varisco; Dieter Willbold; Markus Zweckstetter; Andreas Muhs
Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.
The Journal of biological chemistry 2012;287(41):34786-800.
2012: Roberta Agabio; Mauro A M Carai; Wolfgang Froestl; Gian Luigi Gessa; Paola Maccioni; Giancarlo Colombo
The development of medications for alcohol-use disorders targeting the GABAB receptor system.
Recent patents on CNS drug discovery 2012;7(2):113-28.
2012: Wolfgang Froestl; Andreas Muhs; Andrea Pfeifer
Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors.
Journal of Alzheimer's disease : JAD 2012;32(4):793-887.
2011: Styliani Vlachou; Sebastien Guery; Wolfgang Froestl; Deboshri Banerjee; Jessica Benedict; M G Finn; Athina Markou
Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats.
Psychopharmacology 2011;215(1):117-28.
2011: Styliani Vlachou; Neil E Paterson; Sebastien Guery; Klemens Kaupmann; Wolfgang Froestl; Deboshri Banerjee; M G Finn; Athina Markou
Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats.
European journal of pharmacology 2011;655(1-3):52-8.
2011: Wolfgang Froestl
An historical perspective on GABAergic drugs.
Future medicinal chemistry 2011;3(2):163-75.
2010: Wolfgang Froestl
Novel GABA(B) receptor positive modulators: a patent survey.
Expert opinion on therapeutic patents 2010;20(8):1007-17.
2010: Wolfgang Froestl
Chemistry and pharmacology of GABAB receptor ligands.
Advances in pharmacology (San Diego, Calif.) 2010;58():19-62.
2009: Paola Maccioni; Mauro A M Carai; Klemens Kaupmann; Sébastien Guery; Wolfgang Froestl; Kimberly A Leite-Morris; Gian Luigi Gessa; Giancarlo Colombo
Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.
Alcoholism, clinical and experimental research 2009;33(10):1749-56.
2008: Paola Maccioni; Noemi Fantini; Wolfgang Froestl; Mauro A M Carai; Gian Luigi Gessa; Giancarlo Colombo
Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen.
Alcoholism, clinical and experimental research 2008;32(9):1558-64.
2008: Neil E Paterson; Styliani Vlachou; Sebastien Guery; Klemens Kaupmann; Wolfgang Froestl; Athina Markou
Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.
The Journal of pharmacology and experimental therapeutics 2008;326(1):306-14.
2007: Sébastien Guery; Philipp Floersheim; Klemens Kaupmann; Wolfgang Froestl
Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.
Bioorganic & medicinal chemistry letters 2007;17(22):6206-11.
2007: Paola Maccioni; Daniela Pes; Alessandro Orrù; Wolfgang Froestl; Gian Luigi Gessa; Mauro A M Carai; Giancarlo Colombo
Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats.
Psychopharmacology 2007;193(2):171-8.
2007: Elise M Weerts; Wolfgang Froestl; Barbara J Kaminski; Roland R Griffiths
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons.
Drug and alcohol dependence 2007;89(2-3):206-13.
2006: Amy K Goodwin; Roland R Griffiths; P Rand Brown; Wolfgang Froestl; Cornelis Jakobs; K Michael Gibson; Elise M Weerts
Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons.
Psychopharmacology 2006;189(1):71-82.
2006: Olivier Deschaux; Wolfgang Froestl; Claude Gottesmann
Influence of a GABA(B) and GABA(C) receptor antagonist on sleep-waking cycle in the rat.
European journal of pharmacology 2006;535(1-3):177-81.
2005: Elise M Weerts; Wolfgang Froestl; Roland R Griffiths
Effects of GABAergic modulators on food and cocaine self-administration in baboons.
Drug and alcohol dependence 2005;80(3):369-76.
2005: Neil E Paterson; Adrie W Bruijnzeel; Paul J Kenny; Cory D Wright; Wolfgang Froestl; Athina Markou
Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function.
Neuropharmacology 2005;49(7):953-62.
2005: Alessandro Orrù; Paola Lai; Carla Lobina; Paola Maccioni; Patrizia Piras; Laura Scanu; Wolfgang Froestl; Gian Luigi Gessa; Mauro A M Carai; Giancarlo Colombo
Reducing effect of the positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats.
European journal of pharmacology 2005;525(1-3):105-11.
2005: David A Slattery; Athina Markou; Wolfgang Froestl; John Cryan
The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(11):2065-72.
2005: Amy K Goodwin; Wolfgang Froestl; Elise M Weerts
Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons.
Psychopharmacology 2005;180(2):342-51.
2005: Elise M Weerts; Amy K Goodwin; Roland R Griffiths; P Rand Brown; Wolfgang Froestl; Cornelis Jakobs; K Michael Gibson
Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons.
Psychopharmacology 2005;179(3):678-87.
2005: Daniela Deriu; Martin Gassmann; Susan Firbank; Dorothee Ristig; Christina Lampert; Johannes Mosbacher; Wolfgang Froestl; Klemens Kaupmann; Bernhard Bettler; Markus G Grütter
Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.
The Biochemical journal 2005;386(Pt 3):423-31.
2005: Neil E Paterson; Wolfgang Froestl; Athina Markou
Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(1):119-28.
2004: Mauro A M Carai; Giancarlo Colombo; Wolfgang Froestl; Gian Luigi Gessa
In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor.
European journal of pharmacology 2004;504(3):213-6.
2004: Wolfgang Froestl; Michela Gallagher; Helen Jenkins; Annette Madrid; Thorsten Melcher; Sam Teichman; Cesare G Mondadori; Rodney Pearlman
SGS742: the first GABA(B) receptor antagonist in clinical trials.
Biochemical pharmacology 2004;68(8):1479-87.
2004: John Cryan; Peter Kelly; Frederique CHAPERON; Conrad Gentsch; Cedric Mombereau; Kurt Lingenhoehl; Wolfgang Froestl; Bernhard Bettler; Klemens Kaupmann; Will Spooren
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.
The Journal of pharmacology and experimental therapeutics 2004;310(3):952-63.
2004: Martin Gassmann; Hamdy Shaban; Réjan Vigot; Gilles Sansig; Corinne Haller; Samuel Barbieri; Yann Humeau; Valérie Schuler; Matthias Müller; Bernd Kinzel; Klaus Klebs; Markus Schmutz; Wolfgang Froestl; Jakob Heid; Peter Kelly; Clive Gentry; Anne-Lise Jaton; Herman van der Putten; Cedric Mombereau; Lucas Lecourtier; Johannes Mosbacher; John Cryan; Jean-Marc Fritschy; Andreas Lüthi; Klemens Kaupmann; Bernhard Bettler
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(27):6086-97.
2004: Mauro A M Carai; Giovanni Vacca; Salvatore Serra; Giancarlo Colombo; Wolfgang Froestl; Gian Luigi Gessa
Suppression of GABA(B) receptor function in vivo by disulfide reducing agent, DL-dithiothreitol (DTT).
Psychopharmacology 2004;174(2):283-90.
2004: Cedric Mombereau; Klemens Kaupmann; Wolfgang Froestl; Gilles Sansig; Herman van der Putten; John Cryan
Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(6):1050-62.
2004: Valerio Magnaghi; Marinella Ballabio; Ilaria T R Cavarretta; Wolfgang Froestl; Jeremy J Lambert; Ileana Zucchi; Roberto C Melcangi
GABAB receptors in Schwann cells influence proliferation and myelin protein expression.
The European journal of neuroscience 2004;19(10):2641-9.
2004: Mark A Smith; David L Yancey; Drake Morgan; Yu Liu; Wolfgang Froestl; David Roberts
Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats.
Psychopharmacology 2004;173(1-2):105-11.
2004: Neil E Paterson; Wolfgang Froestl; Athina Markou
The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat.
Psychopharmacology 2004;172(2):179-86.
2003: Klemens Kaupmann; John Cryan; Petrine Wellendorph; Cedric Mombereau; Gilles Sansig; Klaus Klebs; Markus Schmutz; Wolfgang Froestl; Herman van der Putten; Johannes Mosbacher; Hans Bräuner-Osborne; Peter Waldmeier; Bernhard Bettler
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.
The European journal of neuroscience 2003;18(10):2722-30.
2003: Stephan Urwyler; Mario F Pozza; Kurt Lingenhoehl; Johannes Mosbacher; Christina Lampert; Wolfgang Froestl; Manuel Koller; Klemens Kaupmann
N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.
The Journal of pharmacology and experimental therapeutics 2003;307(1):322-30.
2003: Wolfgang Froestl; Bernhard Bettler; Helmut Bittiger; Jakob Heid; Klemens Kaupmann; Stuart J Mickel; Dietrich Strub
Ligands for expression cloning and isolation of GABA(B) receptors.
Farmaco (Società chimica italiana : 1989) 2003;58(3):173-83.
2002: Giancarlo Colombo; Salvatore Serra; Giuliana Brunetti; Giuliana Atzori; Marialaura Pani; Giovanni Vacca; Giovanni Addolorato; Wolfgang Froestl; Mauro A M Carai; Gian Luigi Gessa
The GABA(B) receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats.
Alcohol and alcoholism (Oxford, Oxfordshire) 2002;37(5):499-503.
2002: Maneesh Gupta; Rachel Greven; Erwin E W Jansen; Cornelis Jakobs; Boris M Hogema; Wolfgang Froestl; O Carter Snead; Hilke Bartels; Markus Grompe; K Michael Gibson
Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).
The Journal of pharmacology and experimental therapeutics 2002;302(1):180-7.
2002: K Michael Gibson; D S M Schor; Maneesh Gupta; W S Guerand; Henry Senephansiri; Terry Burlingame; H Bartels; Boris M Hogema; Teodoro Bottiglieri; Wolfgang Froestl; O Carter Snead; Markus Grompe; Cornelis Jakobs
Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase.
Journal of neurochemistry 2002;81(1):71-9.
2002: Karen Brebner; Wolfgang Froestl; David Roberts
The GABA(B) antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat.
Psychopharmacology 2002;160(1):49-55.
2001: Stephan Urwyler; Johannes Mosbacher; Kurt Lingenhoehl; Jakob Heid; K Hofstetter; Wolfgang Froestl; Bernhard Bettler; Klemens Kaupmann
Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.
Molecular pharmacology 2001;60(5):963-71.
2001: Boris M Hogema; Maneesh Gupta; Henry Senephansiri; Terry Burlingame; M Taylor; Cornelis Jakobs; RB Schutgens; Wolfgang Froestl; O Carter Snead; Ramon Diaz-Arrastia; Teodoro Bottiglieri; Markus Grompe; K Michael Gibson
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase.
Nature genetics 2001;29(2):212-6.
2001: Valérie Schuler; Christian Lüscher; C Blanchet; N Klix; Gilles Sansig; Klaus Klebs; Markus Schmutz; Jakob Heid; Clive Gentry; Laszlo Urban; Alyson Fox; Will Spooren; Anne-Lise Jaton; J Vigouret; Mario F Pozza; Peter Kelly; Johannes Mosbacher; Wolfgang Froestl; E Käslin; R Korn; Serge Bischoff; Klemens Kaupmann; Herman van der Putten; Bernhard Bettler
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).
Neuron 2001;31(1):47-58.
2001: D J Macey; Wolfgang Froestl; George F Koob; Athina Markou
Both GABA(B) receptor agonist and antagonists decreased brain stimulation reward in the rat.
Neuropharmacology 2001;40(5):676-85.
2001: Jennifer Ong; Sotiria Bexis; Victor Marino; David A S Parker; David I B Kerr; Wolfgang Froestl
CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain.
European journal of pharmacology 2001;415(2-3):191-5.
2001: Sadhana Patel; S Naeem; Adam Kesingland; Wolfgang Froestl; M Capogna; Laszlo Urban; Alyson Fox
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.
Pain 2001;90(3):217-26.
2001: A Pagano; Giorgio Rovelli; Johannes Mosbacher; T Lohmann; Béatrice Duthey; Daniela Stauffer; Dorothee Ristig; Valérie Schuler; Inge Meigel; Christina Lampert; T Stein; Laurent Prezeau; Jaroslav Blahos; J Pin; Wolfgang Froestl; Rainer Kuhn; Jakob Heid; Klemens Kaupmann; Bernhard Bettler
C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(4):1189-202.
2001: Jennifer Ong; Sotiria Bexis; Victor Marino; David A S Parker; David I B Kerr; Wolfgang Froestl
Comparative activities of the enantiomeric GABA(B) receptor agonists CGP 44532 and 44533 in central and peripheral tissues.
European journal of pharmacology 2001;412(1):27-37.
2001: Wolfgang Froestl; Bernhard Bettler; Helmut Bittiger; Jakob Heid; Klemens Kaupmann; Stuart J Mickel; Dietrich Strub
Ligands for expression cloning and isolation of GABA(B) receptors.
Farmaco (Società chimica italiana : 1989) 2001;56(1-2):101-5.
2000: Thierry Galvez; Laurent Prezeau; G Milioti; M Franek; C Joly; Wolfgang Froestl; Bernhard Bettler; Hugues-Olivier BERTRAND; Jaroslav Blahos; Jean-Philippe Pin
Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors.
The Journal of biological chemistry 2000;275(52):41166-74.
2000: Thierry Galvez; Stephan Urwyler; Laurent Prézeau; Johannes Mosbacher; C Joly; Barbara Malitschek; Jakob Heid; Isabelle Brabet; Wolfgang Froestl; Bernhard Bettler; Klemens Kaupmann; Jean-Philippe Pin
Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.
Molecular pharmacology 2000;57(3):419-26.
1999: Karen Brebner; Wolfgang Froestl; M Andrews; Rachel Phelan; David Roberts
The GABA(B) agonist CGP 44532 decreases cocaine self-administration in rats: demonstration using a progressive ratio and a discrete trials procedure.
Neuropharmacology 1999;38(11):1797-804.
1999: Kurt Lingenhoehl; R Brom; Jakob Heid; P Beck; Wolfgang Froestl; Klemens Kaupmann; Bernhard Bettler; Johannes Mosbacher
Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.
Neuropharmacology 1999;38(11):1667-73.
1999: Wolfgang Froestl; Bernhard Bettler; Helmut Bittiger; Jakob Heid; Klemens Kaupmann; Stuart J Mickel; Dietrich Strub
Ligands for the isolation of GABA(B) receptors [corrected] .
Neuropharmacology 1999;38(11):1641-6.
1999: Jennifer Ong; Victor Marino; David A S Parker; David I B Kerr; Wolfgang Froestl
Pharmacological re-evaluation of a GABA(B) receptor antagonist CGP 47332A in rat brain.
European journal of pharmacology 1999;383(2):137-41.
1999: Barbara Malitschek; C Schweizer; MJ Keir; Jakob Heid; Wolfgang Froestl; Johannes Mosbacher; Rainer Kuhn; J Henley; C Joly; Jean-Philippe Pin; Klemens Kaupmann; Bernhard Bettler
The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.
Molecular pharmacology 1999;56(2):448-54.
1999: Jennifer Ong; David I B Kerr; Wolfgang Froestl
Comparative potencies of CGP 47654A and CGP 46165A as GABA(B) receptor antagonists in rat brain.
European journal of pharmacology 1999;374(3):351-4.
1999: Thierry Galvez; Marie-Laure Parmentier; C Joly; Barbara Malitschek; Klemens Kaupmann; Rainer Kuhn; Helmut Bittiger; Wolfgang Froestl; Bernhard Bettler; Jean-Philippe Pin
Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding.
The Journal of biological chemistry 1999;274(19):13362-9.
1999: Mario F Pozza; NA Manuel; M Steinmann; Wolfgang Froestl; Ceri H Davies
Comparison of antagonist potencies at pre- and post-synaptic GABA(B) receptors at inhibitory synapses in the CA1 region of the rat hippocampus.
British journal of pharmacology 1999;127(1):211-9.
1998: Klemens Kaupmann; Barbara Malitschek; Valérie Schuler; Jakob Heid; Wolfgang Froestl; P Beck; Johannes Mosbacher; Serge Bischoff; Akos Kulik; Ryuichi Shigemoto; Andreas Karschin; Bernhard Bettler
GABA(B)-receptor subtypes assemble into functional heteromeric complexes.
Nature 1998;396(6712):683-7.
1998: Klemens Kaupmann; Valérie Schuler; Johannes Mosbacher; Serge Bischoff; Helmut Bittiger; Jakob Heid; Wolfgang Froestl; S Leonhard; T Pfaff; Andreas Karschin; Bernhard Bettler
Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14991-6.
1998: Jennifer Ong; David I B Kerr; Helmut Bittiger; Peter Waldmeier; P A Baumann; N G Cooke; Stuart J Mickel; Wolfgang Froestl
Morpholin-2-yl-phosphinic acids are potent GABA(B) receptor antagonists in rat brain.
European journal of pharmacology 1998;362(1):27-34.
1997: Klemens Kaupmann; K Huggel; Jakob Heid; P J Flor; Serge Bischoff; Stuart J Mickel; G McMaster; C Angst; Helmut Bittiger; Wolfgang Froestl; Bernhard Bettler
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Nature 1997;386(6622):239-46.
1995: Wolfgang Froestl; Stuart J Mickel; G von Sprecher; P J Diel; R G Hall; L Maier; D Strub; V Melillo; P A Baumann; R Bernasconi
Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
Journal of medicinal chemistry 1995;38(17):3313-31.
1995: Wolfgang Froestl; Stuart J Mickel; R G Hall; G von Sprecher; D Strub; P A Baumann; F Brugger; C Gentsch; J Jaekel; H R Olpe
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Journal of medicinal chemistry 1995;38(17):3297-312.
1993: Helmut Bittiger; Wolfgang Froestl; Stuart J Mickel; H R Olpe
GABAB receptor antagonists: from synthesis to therapeutic applications.
Trends in pharmacological sciences 1993;14(11):391-4.
1993: F Brugger; U Wicki; H R Olpe; Wolfgang Froestl; Stuart J Mickel
The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat.
European journal of pharmacology 1993;235(1):153-5.
1993: H R Olpe; M W Steinmann; T Ferrat; Mario F. Pozza; K Greiner; F Brugger; Wolfgang Froestl; Stuart J Mickel; Helmut Bittiger
The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro.
European journal of pharmacology 1993;233(2-3):179-86.
1990: H R Olpe; G Karlsson; Mario F. Pozza; F Brugger; M Steinmann; H Van Riezen; G Fagg; R G Hall; Wolfgang Froestl; Helmut Bittiger
CGP 35348: a centrally active blocker of GABAB receptors.
European journal of pharmacology 1990;187(1):27-38.