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Marie-Thérèse Froment

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Chemicals & Drugs

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Marie Trovaslet-Leroy; Laurent Verdier; Ladislav Novotny; Frédérique Renault; Daniel Rochu; Xavier Brazzolotto; Marie-Thérèse Froment; Emilie Gillon; Daniel Jun; Mélanie Loiodice; Patrick Masson; Jan Misik; Lucie Musilova; Florian Nachon
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.
Eugénie Carletti; Jacques-Philippe Colletier; Marie-Thérèse Froment; Oksana Lockridge; Florian Nachon; Lawrence M Schopfer; Martin Weik; Patrick Masson
Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis.
Marie Trovaslet-Leroy; Claude Jolivalt; Marie-Thérèse Froment; Bernardin Brasme; Bertrand Lefebvre; Denis Daveloose; Florian Nachon; Patrick Masson
Application of laccase-mediator system (LMS) for the degradation of organophosphorus compounds.

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All Publications

2011: Marie Trovaslet-Leroy; Laurent Verdier; Ladislav Novotny; Frédérique Renault; Daniel Rochu; Xavier Brazzolotto; Marie-Thérèse Froment; Emilie Gillon; Daniel Jun; Mélanie Loiodice; Patrick Masson; Jan Misik; Lucie Musilova; Florian Nachon
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.
Toxicology letters 2011;206(1):14-23.
2011: Eugénie Carletti; Jacques-Philippe Colletier; Marie-Thérèse Froment; Oksana Lockridge; Florian Nachon; Lawrence M Schopfer; Martin Weik; Patrick Masson
Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis.
Chemical research in toxicology 2011;24(6):797-808.
2010: Marie Trovaslet-Leroy; Claude Jolivalt; Marie-Thérèse Froment; Bernardin Brasme; Bertrand Lefebvre; Denis Daveloose; Florian Nachon; Patrick Masson
Application of laccase-mediator system (LMS) for the degradation of organophosphorus compounds.
Chemico-biological interactions 2010;187(1-3):393-6.
2008: Eugénie Carletti; He Li; Bin Li; Fredrik Ekström; Yvain Nicolet; Mélanie Loiodice; Emilie Gillon; Marie-Thérèse Froment; Oksana Lockridge; Lawrence M Schopfer; Patrick Masson; Florian Nachon
Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.
Journal of the American Chemical Society 2008;130(47):16011-20.
2008: Frédéric Dorandeu; A Foquin; R Briot; C Delacour; J Denis; A Alonso; Marie-Thérèse Froment; Frédérique Renault; Guy Lallement; Patrick Masson
An unexpected plasma cholinesterase activity rebound after challenge with a high dose of the nerve agent VX.
Toxicology 2008;248(2-3):151-7.
2008: Bin Li; Florian Nachon; Marie-Thérèse Froment; Laurent Verdier; Jean-Claude Debouzy; Bernardo Brasme; Emilie Gillon; Lawrence M Schopfer; Oksana Lockridge; Patrick Masson
Binding and hydrolysis of soman by human serum albumin.
Chemical research in toxicology 2008;21(2):421-31.
2007: He Li; Lawrence M Schopfer; Florian Nachon; Marie-Thérèse Froment; Patrick Masson; Oksana Lockridge
Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):136-45.
2007: Patrick Masson; Marie-Thérèse Froment; Emilie Gillon; Florian Nachon; Sultan Darvesh; Lawrence M Schopfer
Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides.
Biochimica et biophysica acta 2007;1774(9):1139-47.
2007: Patrick Masson; Marie-Thérèse Froment; Sultan Darvesh; Lawrence M Schopfer; Oksana Lockridge
Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate.
Journal of enzyme inhibition and medicinal chemistry 2007;22(4):463-9.
2007: Patrick Masson; Marie-Thérèse Froment; Emilie Gillon; Florian Nachon; Oksana Lockridge; Lawrence M Schopfer
Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase.
Biochimica et biophysica acta 2007;1774(1):16-34.
2006: Thomas Poyot; Florian Nachon; Marie-Thérèse Froment; Mélanie Loiodice; Stacy Wieseler; Lawrence M Schopfer; Oksana Lockridge; Patrick Masson
Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters.
Biochimica et biophysica acta 2006;1764(9):1470-8.
2006: Anna Hrabovská; Jean-Claude Debouzy; Marie-Thérèse Froment; Ferdinand Devínsky; Ingrid Pauliková; Patrick Masson
Rat butyrylcholinesterase-catalysed hydrolysis of N-alkyl homologues of benzoylcholine.
The FEBS journal 2006;273(6):1185-97.
2005: Patrick Masson; Lawrence M Schopfer; Marie-Thérèse Froment; Jean-Claude Debouzy; Florian Nachon; Emilie Gillon; Oksana Lockridge; Anna Hrabovska; Boris N Goldstein
Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics.
Chemico-biological interactions 2005;157-158():143-52.
2005: Nicolas Masurier; François Estour; Marie-Thérèse Froment; Bertrand Lefèvre; Jean-Claude Debouzy; Bernard Brasme; Patrick Masson; Olivier Lafont
Synthesis of 2-substituted beta-cyclodextrin derivatives with a hydrolytic activity against the organophosphorylester paraoxon.
European journal of medicinal chemistry 2005;40(7):615-23.
2004: Patrick Masson; Nicole Bec; Marie-Thérèse Froment; Florian Nachon; Claude Balny; Oksana Lockridge; Lawrence M Schopfer
Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior.
European journal of biochemistry / FEBS 2004;271(10):1980-90.
2004: Patrick Masson; Boris N Goldstein; Jean-Claude Debouzy; Marie-Thérèse Froment; Oksana Lockridge; Lawrence M Schopfer
Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate.
European journal of biochemistry / FEBS 2004;271(1):220-34.
2003: Patrick Masson; Florian Nachon; Cynthia F Bartels; Marie-Thérèse Froment; Fabien Ribes; Cedric Matthews; Oksana Lockridge
High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine.
European journal of biochemistry / FEBS 2003;270(2):315-24.
2002: Patrick Masson; Marie-Thérèse Froment; Sébastien Fort; Fabien Ribes; Nicole Bec; Claude Balny; Lawrence M Schopfer
Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior.
Biochimica et biophysica acta 2002;1597(2):229-43.
2002: Patrick Masson; Lawrence M Schopfer; Cynthia F Bartels; Marie-Thérèse Froment; Fabien Ribes; Florian Nachon; Oksana Lockridge
Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite.
Biochimica et biophysica acta 2002;1594(2):313-24.
2002: Jure Stojan; Marko Golicnik; Marie-Thérèse Froment; Francois Estour; Patrick Masson
Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion.
European journal of biochemistry / FEBS 2002;269(4):1154-61.
2001: Patrick Masson; W Xie; Marie-Thérèse Froment; Oksana Lockridge
Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase.
Biochimica et biophysica acta 2001;1544(1-2):166-76.
1999: Patrick Masson; W Xie; Marie-Thérèse Froment; V Levitsky; PL Fortier; C Albaret; Oksana Lockridge
Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates.
Biochimica et biophysica acta 1999;1433(1-2):281-93.
1999: V Levitsky; W Xie; Marie-Thérèse Froment; Oksana Lockridge; Patrick Masson
Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant.
Biochimica et biophysica acta 1999;1429(2):422-30.
1998: Marie-Thérèse Froment; Oksana Lockridge; Patrick Masson
Resistance of butyrylcholinesterase to inactivation by ultrasound: effects of ultrasound on catalytic activity and subunit association.
Biochimica et biophysica acta 1998;1387(1-2):53-64.
1998: Patrick Masson; Marie-Thérèse Froment; PL Fortier; J E Visicchio; Cynthia F Bartels; Oksana Lockridge
Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters.
Biochimica et biophysica acta 1998;1387(1-2):41-52.
1997: Patrick Masson; PL Fortier; C Albaret; Marie-Thérèse Froment; Cynthia F Bartels; Oksana Lockridge
Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.
The Biochemical journal 1997;327 ( Pt 2)():601-7.
1997: Patrick Masson; Marie-Thérèse Froment; Cynthia F Bartels; Oksana Lockridge
Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase.
The Biochemical journal 1997;325 ( Pt 1)():53-61.
1997: Patrick Masson; P Legrand; Cynthia F Bartels; Marie-Thérèse Froment; Lawrence M Schopfer; Oksana Lockridge
Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase.
Biochemistry 1997;36(8):2266-77.
1997: Oksana Lockridge; R M Blong; Patrick Masson; Marie-Thérèse Froment; Charles B Millard; Clarence A Broomfield
A single amino acid substitution, Gly117His, confers phosphotriesterase (organophosphorus acid anhydride hydrolase) activity on human butyrylcholinesterase.
Biochemistry 1997;36(4):786-95.
1996: Patrick Masson; Marie-Thérèse Froment; Cynthia F Bartels; Oksana Lockridge
Asp7O in the peripheral anionic site of human butyrylcholinesterase.
European journal of biochemistry / FEBS 1996;235(1-2):36-48.
1994: Patrick Masson; Marie-Thérèse Froment; R C Sorenson; Cynthia F Bartels; Oksana Lockridge
Mutation His322Asn in human acetylcholinesterase does not alter electrophoretic and catalytic properties of the erythrocyte enzyme.
Blood 1994;83(10):3003-5.