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Bernard Fromenty

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Sébastien Anthérieu; Julie Dumont; Bernard Fromenty; Christiane Guguen-Guillouzo; Marie-Anne Robin; Pamela Bachour-El Azzi; Ziad Abdel-Razzak; André Guillouzo
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.
thomas Gicquel; Sylvie Lepage; Jacinthe Aubert; Bernard Fromenty; Isabelle Morel
Quantitative analysis of acetaminophen and its primary metabolites in small plasma volumes by liquid chromatography-tandem mass spectrometry.
Bernard Fromenty
Bridging the gap between old and new concepts in drug-induced liver injury.

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2013: Sébastien Anthérieu; Julie Dumont; Bernard Fromenty; Christiane Guguen-Guillouzo; Marie-Anne Robin; Pamela Bachour-El Azzi; Ziad Abdel-Razzak; André Guillouzo
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.
Hepatology (Baltimore, Md.) 2013;57(4):1518-29.
2013: thomas Gicquel; Sylvie Lepage; Jacinthe Aubert; Bernard Fromenty; Isabelle Morel
Quantitative analysis of acetaminophen and its primary metabolites in small plasma volumes by liquid chromatography-tandem mass spectrometry.
Journal of analytical toxicology 2013;37(2):110-6.
2013: Bernard Fromenty
Bridging the gap between old and new concepts in drug-induced liver injury.
Clinics and research in hepatology and gastroenterology 2013;37(1):6-9.
2012: Mathieu Porceddu; Célestin Roussel; Nelly Buron; Bernard Fromenty; Gilles Labbe; Annie Borgne-Sanchez
Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria.
Toxicological sciences : an official journal of the Society of Toxicology 2012;129(2):332-45.
2012: Jacinthe Aubert; Karima Begriche; Matthieu Delannoy; Hartmut Jaeschke; Sylvie Lepage; Catherine Lucas-Clerc; Mitchell R McGill; Isabelle Morel; Julie Pajaud; Catherine Ribault; Marie-Anne Robin; Bruno Turlin; Bernard Fromenty
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
The Journal of pharmacology and experimental therapeutics 2012;342(3):676-87.
2012: Mélissa Flamment; Bernard Fromenty; Yves Malthièry; Jennifer Rieusset; Gilles Simard; Hubert Vidal; Pierre-Henri Ducluzeau
Regulation of hepatic mitochondrial metabolism in response to a high fat diet: a longitudinal study in rats.
Journal of physiology and biochemistry 2012;68(3):335-44.
2012: Nilanjan Das; Bernard Fromenty; Santinath Ghosh; Kunal Sikder; Sanjit Dey
Moringa oleifera Lam. leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet.
Indian journal of experimental biology 2012;50(6):404-12.
2012: Laetitia Knockaert; Sylvie Lepage; Catherine Lucas-Clerc; Julie Pajaud; Pierre-Emmanuel Prost; Catherine Ribault; Jean-Marc Bégué; Alain Berson; Alain Fautrel; Bernard Fromenty; Marie-Anne Robin
Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver.
Laboratory investigation; a journal of technical methods and pathology 2012;92(3):396-410.
2012: J Massart; F Noury; P A Eliat; M A Robin; André Bado; Alain Fautrel; Philippe Lettéron; Bernard Fromenty
Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.
British journal of pharmacology 2012;165(5):1361-74.
2012: Dominique Pessayre; Marie-Anne Robin; Richard Moreau; Alain Berson; Bernard Fromenty; Philippe Lettéron; Abdellah Mansouri
Central role of mitochondria in drug-induced liver injury.
Drug metabolism reviews 2012;44(1):34-87.
2011: Viviane Trak-Smayra; Victor Jebara; Julie Massart; Selim Nasser; Valérie Paradis; Bernard Fromenty
Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet.
International journal of experimental pathology 2011;92(6):413-21.
2011: Laetitia Knockaert; Bernard Fromenty; Marie-Anne Robin
Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.
The FEBS journal 2011;278(22):4252-60.
2011: J Aubert; Karima Begriche; L Knockaert; M A Robin; Bernard Fromenty
Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.
Clinics and research in hepatology and gastroenterology 2011;35(10):630-7.
2011: Meriem Mahrouf-Yorgov; Claudia Mitchell; Abdelhamid Slama; Jacques-Emmanuel Guidotti; Elsa Abdoun; Claudine Cosson; Alexandra Collin de L'hortet; Bernard Fromenty; Hélène Gilgenkrantz
Increased susceptibility to liver fibrosis with age is correlated with an altered inflammatory response.
Rejuvenation research 2011;14(4):353-63.
2011: Sébastien Anthérieu; Alexandra Rogue; Bernard Fromenty; André Guillouzo; Marie-Anne Robin
Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells.
Hepatology (Baltimore, Md.) 2011;53(6):1895-905.
2011: Karima Begriche; Julie Massart; Marie-Anne Robin; Annie Borgne-Sanchez; Bernard Fromenty
Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.
Journal of hepatology 2011;54(4):773-94.
2011: Laetitia Knockaert; Véronique Descatoire; Nathalie Vadrot; Bernard Fromenty; Marie-Anne Robin
Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(2):475-84.
2011: Claudia Mitchell; Meriem Mahrouf-Yorgov; Alicia Mayeuf; Marie-Anne Robin; Abdellah Mansouri; Bernard Fromenty; Hélène Gilgenkrantz
Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease.
Laboratory investigation; a journal of technical methods and pathology 2011;91(2):273-82.
2010: Karima Begriche; Julie Massart; Bernard Fromenty
Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity.
Fundamental & clinical pharmacology 2010;24(3):269-82.
2010: Isabelle Larosche; Philippe Lettéron; Alain Berson; Bernard Fromenty; Ting-Ting Huang; Richard Moreau; Dominique Pessayre; Abdellah Mansouri
Hepatic mitochondrial DNA depletion after an alcohol binge in mice: probable role of peroxynitrite and modulation by manganese superoxide dismutase.
The Journal of pharmacology and experimental therapeutics 2010;332(3):886-97.
2010: Abdellah Mansouri; Arige Tarhuni; Isabelle Larosche; FLORENCE REYL-DESMARS; Christine Demeilliers; Françoise Degoul; Pierre Nahon; Angela SUTTON; Richard Moreau; Bernard Fromenty; Dominique Pessayre
MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice.
Digestive diseases (Basel, Switzerland) 2010;28(6):756-75.
2010: Dominique Pessayre; Abdellah Mansouri; Alain Berson; Bernard Fromenty
Mitochondrial involvement in drug-induced liver injury.
Handbook of experimental pharmacology 2010;(196):311-65.
2009: Claudia Mitchell; Marie-Anne Robin; Alicia Mayeuf; Meriem Mahrouf-Yorgov; Abdellah Mansouri; Marie Hamard; Dominique Couton; Bernard Fromenty; Hélène Gilgenkrantz
Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice.
The American journal of pathology 2009;175(5):1929-37.
2009: Bernard Fromenty; Nathalie Vadrot; Julie Massart; Bruno Turlin; Nadège Barri-Ova; Philippe Lettéron; Alain Fautrel; Marie-Anne Robin
Chronic ethanol consumption lessens the gain of body weight, liver triglycerides, and diabetes in obese ob/ob mice.
The Journal of pharmacology and experimental therapeutics 2009;331(1):23-34.
2009: Isabelle Larosche; Amal Choumar; Bernard Fromenty; Philippe Lettéron; Adjé Abbey-Toby; Holly Van Remmen; Charles J Epstein; Arlan G Richardson; Gérard Feldmann; Dominique Pessayre; Abdellah Mansouri
Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.
Toxicology and applied pharmacology 2009;234(3):326-38.
2008: Karima Begriche; Julie Massart; Adjé Abbey-Toby; Anissa Igoudjil; Philippe Lettéron; Bernard Fromenty
Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency.
Obesity (Silver Spring, Md.) 2008;16(9):2053-67.
2008: Gilles Labbe; Dominique Pessayre; Bernard Fromenty
Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies.
Fundamental & clinical pharmacology 2008;22(4):335-53.
2008: Anissa Igoudjil; Julie Massart; Karima Begriche; Véronique Descatoire; Marie-Anne Robin; Bernard Fromenty
High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(4):887-98.
2008: Karima Begriche; Philippe Lettéron; Adjé Abbey-Toby; Nathalie Vadrot; Marie-Anne Robin; André Bado; Dominique Pessayre; Bernard Fromenty
Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E939-51.
2007: Isabelle Larosche; Philippe Lettéron; Bernard Fromenty; Nathalie Vadrot; Adjé Abbey-Toby; Gérard Feldmann; Dominique Pessayre; Abdellah Mansouri
Tamoxifen inhibits topoisomerases, depletes mitochondrial DNA, and triggers steatosis in mouse liver.
The Journal of pharmacology and experimental therapeutics 2007;321(2):526-35.
2007: Sophie Cazanave; Alain Berson; Delphine Haouzi; Nathalie Vadrot; Daniel Fau; Alain Grodet; Philippe Lettéron; Gérard Feldmann; Jamel El Benna; Bernard Fromenty; Marie-Anne Robin; Dominique Pessayre
High hepatic glutathione stores alleviate Fas-induced apoptosis in mice.
Journal of hepatology 2007;46(5):858-68.
2007: Anissa Igoudjil; Adjé Abbey-Toby; Karima Begriche; Alain Grodet; Karine Chataigner; Gilles Peytavin; Mustapha Maachi; Marion Colin; Marie-Anne Robin; Philippe Lettéron; Gérard Feldmann; Dominique Pessayre; Bernard Fromenty
High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice.
Antiviral therapy 2007;12(3):389-400.
2006: Karima Begriche; Anissa Igoudjil; Dominique Pessayre; Bernard Fromenty
Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.
Mitochondrion 2006;6(1):1-28.
2005: Marie-Anne Robin; Ingrid Sauvage; Thomas Grandperret; Véronique Descatoire; Dominique Pessayre; Bernard Fromenty
Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes.
FEBS letters 2005;579(30):6895-902.
2005: Marie-Anne Robin; Christine Demeilliers; Angela SUTTON; Valérie Paradis; Caroline Maisonneuve; Sylvie Dubois; Odile Poirel; Philippe Lettéron; Dominique Pessayre; Bernard Fromenty
Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice.
Hepatology (Baltimore, Md.) 2005;42(6):1280-90.
2005: Dominique Pessayre; Bernard Fromenty
NASH: a mitochondrial disease.
Journal of hepatology 2005;42(6):928-40.
2005: Frédéric Petit; Bernard Fromenty; Andrew Owen; Jérôme Estaquier
Mitochondria are sensors for HIV drugs.
Trends in pharmacological sciences 2005;26(5):258-64.
2004: Dominique Pessayre; Bernard Fromenty; Abdellah Mansouri
Mitochondrial injury in steatohepatitis.
European journal of gastroenterology & hepatology 2004;16(11):1095-105.
2004: Caroline Maisonneuve; Anissa Igoudjil; Karima Begriche; Philippe Lettéron; Marie-Christine Guimont; Jean Bastin; Jean-Pierre Laigneau; Dominique Pessayre; Bernard Fromenty
Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting.
Antiviral therapy 2004;9(5):801-10.
2004: Bernard Fromenty; Marie-Anne Robin; Anissa Igoudjil; Abdellah Mansouri; Dominique Pessayre
The ins and outs of mitochondrial dysfunction in NASH.
Diabetes & metabolism 2004;30(2):121-38.
2004: Marie-lise GOUGEON; Luc Pénicaud; Bernard Fromenty; Pascale Leclercq; Jean-Paul Viard; Jacqueline Capeau
Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations.
Antiviral therapy 2004;9(2):161-77.
2003: Reine Note; Caroline Maisonneuve; Philippe Lettéron; Gilles Peytavin; Fatima Djouadi; Anissa Igoudjil; Marie-Christine Guimont; Michel Biour; Dominique Pessayre; Bernard Fromenty
Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments.
Antimicrobial agents and chemotherapy 2003;47(11):3384-92.
2003: Abdellah Mansouri; Delphine Haouzi; Véronique Descatoire; Christine Demeilliers; Angela SUTTON; Nathalie Vadrot; Bernard Fromenty; Gérard Feldmann; Dominique Pessayre; Alain Berson
Tacrine inhibits topoisomerases and DNA synthesis to cause mitochondrial DNA depletion and apoptosis in mouse liver.
Hepatology (Baltimore, Md.) 2003;38(3):715-25.
2003: Philippe Ichai; Emmanuel Huguet; Catherine Guettier; Daniel Azoulay; Maria Eugenia Gonzalez; Bernard Fromenty; Pascal Masnou; Faouzi Saliba; Bruno Roche; Fahed Zeitoun; Denis Castaing; Didier Samuel
Fulminant hepatitis after grand mal seizures: mechanisms and role of liver transplantation.
Hepatology (Baltimore, Md.) 2003;38(2):443-51.
2003: Philippe Lettéron; Angela SUTTON; Abdellah Mansouri; Bernard Fromenty; Dominique Pessayre
Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice.
Hepatology (Baltimore, Md.) 2003;38(1):133-40.
2002: Christine Demeilliers; Caroline Maisonneuve; Alain Grodet; Abdellah Mansouri; Richard Nguyen; Marina Tinel; Philippe Lettéron; Claude Degott; Gérard Feldmann; Dominique Pessayre; Bernard Fromenty
Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice.
Gastroenterology 2002;123(4):1278-90.
2002: Alan Cahill; Carol C Cunningham; Masayuki Adachi; Hiromasa Ishii; Shannon M Bailey; Bernard Fromenty; Adrian Davies
Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion.
Alcoholism, clinical and experimental research 2002;26(6):907-15.
2002: Dominique Pessayre; Abdellah Mansouri; Bernard Fromenty
Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(2):G193-9.
2001: Abdellah Mansouri; Christine Demeilliers; S Amsellem; Dominique Pessayre; Bernard Fromenty
Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants.
The Journal of pharmacology and experimental therapeutics 2001;298(2):737-43.
2001: Françoise Degoul; Angela SUTTON; Abdellah Mansouri; Claude Cepanec; C Degott; Bernard Fromenty; Michel Beaugrand; D Valla; Dominique Pessayre
Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease.
Gastroenterology 2001;120(6):1468-74.
2001: I Gaou; M Malliti; Marie-Christine Guimont; Philippe Lettéron; Christine Demeilliers; Gilles Peytavin; Claude Degott; Dominique Pessayre; Bernard Fromenty
Effect of stavudine on mitochondrial genome and fatty acid oxidation in lean and obese mice.
The Journal of pharmacology and experimental therapeutics 2001;297(2):516-23.
2001: Dominique Pessayre; Alain Berson; Bernard Fromenty; Abdellah Mansouri
Mitochondria in steatohepatitis.
Seminars in liver disease 2001;21(1):57-69.
2000: Bernard Fromenty; Christine Demeilliers; Abdellah Mansouri; Dominique Pessayre
Escherichia coli exonuclease III enhances long PCR amplification of damaged DNA templates.
Nucleic acids research 2000;28(11):E50.
2000: Bernard Fromenty; Abdellah Mansouri; Françoise Degoul; Christine Demeilliers; I Gaou; Dominique Pessayre
[Ageing, alcohol and mitochondria].
Gastroentérologie clinique et biologique 2000;24(3):349-58.
1999: Abdellah Mansouri; I Gaou; C De Kerguenec; S Amsellem; Delphine Haouzi; Alain Berson; A Moreau; Gérard Feldmann; Philippe Lettéron; Dominique Pessayre; Bernard Fromenty
An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice.
Gastroenterology 1999;117(1):181-90.
1999: Dominique Pessayre; Abdellah Mansouri; Delphine Haouzi; Bernard Fromenty
Hepatotoxicity due to mitochondrial dysfunction.
Cell biology and toxicology 1999;15(6):367-73.
1998: Alain Berson; V De Beco; Philippe Lettéron; Marie-Anne Robin; C Moreau; J El Kahwaji; N Verthier; Gérard Feldmann; Bernard Fromenty; Dominique Pessayre
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.
Gastroenterology 1998;114(4):764-74.
1998: Alain Berson; Bernard Fromenty; Philippe Lettéron; Dominique Pessayre
[Role of mitochondria in drug-induced hepatotoxicity].
Gastroentérologie clinique et biologique 1998;22(1):59-72.
1997: Abdellah Mansouri; I Gaou; Bernard Fromenty; Alain Berson; Philippe Lettéron; Claude Degott; S Erlinger; Dominique Pessayre
Premature oxidative aging of hepatic mitochondrial DNA in Wilson's disease.
Gastroenterology 1997;113(2):599-605.
1997: Abdellah Mansouri; Bernard Fromenty; Alain Berson; Marie-Anne Robin; S Grimbert; Michel Beaugrand; S Erlinger; Dominique Pessayre
Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients.
Journal of hepatology 1997;27(1):96-102.
1997: Bernard Fromenty; Dominique Pessayre
Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines.
Journal of hepatology 1997;26 Suppl 2():43-53.
1997: Bernard Fromenty; Alain Berson; Dominique Pessayre
Microvesicular steatosis and steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation.
Journal of hepatology 1997;26 Suppl 1():13-22.
1996: Abdellah Mansouri; Bernard Fromenty; F Durand; C Degott; J Bernuau; D Pessayre
Assessment of the prevalence of genetic metabolic defects in acute fatty liver of pregnancy.
Journal of hepatology 1996;25(5):781.
1996: Alain Berson; S Renault; Philippe Lettéron; Marie-Anne Robin; Bernard Fromenty; Daniel Fau; M A Le Bot; C Riché; A M Durand-Schneider; Gérard Feldmann; Dominique Pessayre
Uncoupling of rat and human mitochondria: a possible explanation for tacrine-induced liver dysfunction.
Gastroenterology 1996;110(6):1878-90.
1996: Bernard Fromenty; Abdellah Mansouri; J P Bonnefont; F Courtois; A Munnich; D Rabier
Most cases of medium-chain acyl-CoA dehydrogenase deficiency escape detection in France.
Human genetics 1996;97(3):367-8.
1996: P Letteron; Bernard Fromenty; B Terris; C Degott; D Pessayre
Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice.
Journal of hepatology 1996;24(2):200-8.
1996: C Fisch; M A Robin; P Letteron; Bernard Fromenty; Alain Berson; S Renault; C Chachaty; Dominique Pessayre
Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo.
Gastroenterology 1996;110(1):210-20.
1995: S Grimbert; C Fisch; D Deschamps; Alain Berson; Bernard Fromenty; Gérard Feldmann; Dominique Pessayre
Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancy.
The American journal of physiology 1995;268(1 Pt 1):G107-15.
1995: Bernard Fromenty; S Grimbert; Abdellah Mansouri; M Beaugrand; S Erlinger; A Rötig; Dominique Pessayre
Hepatic mitochondrial DNA deletion in alcoholics: association with microvesicular steatosis.
Gastroenterology 1995;108(1):193-200.
1995: Bernard Fromenty; Dominique Pessayre
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity.
Pharmacology & therapeutics 1995;67(1):101-54.
1994: Alain Berson; L Schmets; C Fisch; Daniel Fau; C Wolf; Bernard Fromenty; D Deschamps; Dominique Pessayre
Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen.
The Journal of pharmacology and experimental therapeutics 1994;270(1):167-76.
1994: Daniel Fau; D Eugene; Alain Berson; P Letteron; Bernard Fromenty; C Fisch; Dominique Pessayre
Toxicity of the antiandrogen flutamide in isolated rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1994;269(3):954-62.
1994: D Deschamps; V DeBeco; C Fisch; Bernard Fromenty; A Guillouzo; Dominique Pessayre
Inhibition by perhexiline of oxidative phosphorylation and the beta-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions.
Hepatology (Baltimore, Md.) 1994;19(4):948-61.
1994: Alain Berson; E Fréneaux; D Larrey; Virginia Lepage; Corinne Douay; C Mallet; Bernard Fromenty; Jean-Pierre Benhamou; Dominique Pessayre
Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis.
Journal of hepatology 1994;20(3):336-42.
1993: Bernard Fromenty; P Letteron; C Fisch; Alain Berson; D Deschamps; Dominique Pessayre
Evaluation of human blood lymphocytes as a model to study the effects of drugs on human mitochondria. Effects of low concentrations of amiodarone on fatty acid oxidation, ATP levels and cell survival.
Biochemical pharmacology 1993;46(3):421-32.
1993: S Grimbert; Bernard Fromenty; C Fisch; P Letteron; Alain Berson; A M Durand-Schneider; Gérard Feldmann; Dominique Pessayre
Decreased mitochondrial oxidation of fatty acids in pregnant mice: possible relevance to development of acute fatty liver of pregnancy.
Hepatology (Baltimore, Md.) 1993;17(4):628-37.
1993: Philippe Lettéron; V Duchatelle; Alain Berson; Bernard Fromenty; C Fisch; Claude Degott; J P Benhamou; Dominique Pessayre
Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers.
Gut 1993;34(3):409-14.
1992: Daniel Fau; Alain Berson; D Eugene; Bernard Fromenty; C Fisch; Dominique Pessayre
Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes.
The Journal of pharmacology and experimental therapeutics 1992;263(1):69-77.
1992: V Berger; Alain Berson; C Wolf; C Chachaty; Daniel Fau; Bernard Fromenty; Dominique Pessayre
Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen.
Biochemical pharmacology 1992;43(3):654-7.
1991: D Deschamps; C Fisch; Bernard Fromenty; Alain Berson; Claude Degott; Dominique Pessayre
Inhibition by salicylic acid of the activation and thus oxidation of long chain fatty acids. Possible role in the development of Reye's syndrome.
The Journal of pharmacology and experimental therapeutics 1991;259(2):894-904.
1991: Alain Berson; C Wolf; V Berger; Daniel Fau; C Chachaty; Bernard Fromenty; Dominique Pessayre
Generation of free radicals during the reductive metabolism of the nitroaromatic compound, nilutamide.
The Journal of pharmacology and experimental therapeutics 1991;257(2):714-9.
1991: G Labbe; Bernard Fromenty; E Freneaux; V Morzelle; P Letteron; Alain Berson; Dominique Pessayre
Effects of various tetracycline derivatives on in vitro and in vivo beta-oxidation of fatty acids, egress of triglycerides from the liver, accumulation of hepatic triglycerides, and mortality in mice.
Biochemical pharmacology 1991;41(4):638-41.
1990: Bernard Fromenty; C Fisch; G Labbe; Claude Degott; D Deschamps; Alain Berson; P Letteron; Dominique Pessayre
Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1371-6.
1990: Bernard Fromenty; C Fisch; Alain Berson; P Letteron; D Larrey; Dominique Pessayre
Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1377-84.
1990: E Freneaux; Bernard Fromenty; Alain Berson; G Labbe; Claude Degott; P Letteron; D Larrey; Dominique Pessayre
Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial beta-oxidation of fatty acids.
The Journal of pharmacology and experimental therapeutics 1990;255(2):529-35.
1990: Philippe Lettéron; G Labbe; Claude Degott; Alain Berson; Bernard Fromenty; M Delaforge; D Larrey; Dominique Pessayre
Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant.
Biochemical pharmacology 1990;39(12):2027-34.
1989: Bernard Fromenty; E Freneaux; G Labbe; D Deschamps; D Larrey; P Letteron; Dominique Pessayre
Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice.
Biochemical pharmacology 1989;38(21):3743-51.