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Herbert Fromm

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
56
Honzatko, Richard
12
Aleshin, Alexander
10
Choe, Jun-Yong
10
Poland, BW
10
Nelson, Scott
8
Iancu, Cristina
6
Hou, Zhenglin
6
Gorrell, Andrea
6
Wang, Wenyan
5
Borza, Tudor
4
Hines, Justin
3
Kim, Chang Sup
3
Bartunik, Hans
3
Zeng, C
3
Colman, Roberta

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Publications

TOP 3
Fan Chenguang; Fromm Herbert J; Bobik Thomas A
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
Hines Justin K; Chen Xiaoming; Nix Jay C; Fromm Herbert J; Honzatko Richard B
Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition.
Hines Justin K; Kruesel Claire E; Fromm Herbert J; Honzatko Richard B
Structure of inhibited fructose-1,6-bisphosphatase from Escherichia coli: distinct allosteric inhibition sites for AMP and glucose 6-phosphate and the characterization of a gluconeogenic switch.

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All Publications

2009: Fan Chenguang; Fromm Herbert J; Bobik Thomas A
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
The Journal of biological chemistry 2009;284(30):20240-8.
2007: Hines Justin K; Chen Xiaoming; Nix Jay C; Fromm Herbert J; Honzatko Richard B
Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition.
The Journal of biological chemistry 2007;282(49):36121-31.
2007: Hines Justin K; Kruesel Claire E; Fromm Herbert J; Honzatko Richard B
Structure of inhibited fructose-1,6-bisphosphatase from Escherichia coli: distinct allosteric inhibition sites for AMP and glucose 6-phosphate and the characterization of a gluconeogenic switch.
The Journal of biological chemistry 2007;282(34):24697-706.
2007: Hines Justin K; Fromm Herbert J; Honzatko Richard B
Structures of activated fructose-1,6-bisphosphatase from Escherichia coli. Coordinate regulation of bacterial metabolism and the conservation of the R-state.
The Journal of biological chemistry 2007;282(16):11696-704.
2006: Iancu Cristina V; Zhou Yang; Borza Tudor; Fromm Herbert J; Honzatko Richard B
Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.
Biochemistry 2006;45(38):11703-11.
2006: Ginder Nathaniel D; Binkowski Daniel J; Fromm Herbert J; Honzatko Richard B
Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase.
The Journal of biological chemistry 2006;281(30):20680-8.
2006: Hines Justin K; Fromm Herbert J; Honzatko Richard B
Novel allosteric activation site in Escherichia coli fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2006;281(27):18386-93.
2005: Skaff D Andrew; Kim Chang Sup; Tsai Henry J; Honzatko Richard B; Fromm Herbert J
Glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria.
The Journal of biological chemistry 2005;280(46):38403-9.
2005: Iancu Cristina V; Mukund Susmith; Fromm Herbert J; Honzatko Richard B
R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2005;280(20):19737-45.
2005: Nelson Scott W; Binkowski Daniel J; Honzatko Richard B; Fromm Herbert J
Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.
Biochemistry 2005;44(2):766-74.
2004: Nelson Scott W; Honzatko Richard B; Fromm Herbert J
Origin of cooperativity in the activation of fructose-1,6-bisphosphatase by Mg2+.
The Journal of biological chemistry 2004;279(18):18481-7.
2003: Choe Jun-Young; Nelson Scott W; Arienti Kristen L; Axe Frank U; Collins Tassie L; Jones Todd K; Kimmich Rachel D A; Newman Michael J; Norvell Karl; Ripka William C; Romano Suzanne J; Short Kevin M; Slee Deborah H; Fromm Herbert J; Honzatko Richard B
Inhibition of fructose-1,6-bisphosphatase by a new class of allosteric effectors.
The Journal of biological chemistry 2003;278(51):51176-83.
2003: Choe Jun-Yong; Nelson Scott W; Fromm Herbert J; Honzatko Richard B
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2003;278(18):16008-14.
2003: Choe Jun-Yong; Iancu Cristina V; Fromm Herbert J; Honzatko Richard B
Metaphosphate in the active site of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2003;278(18):16015-20.
2003: Borza Tudor; Iancu Cristina V; Pike Evan; Honzatko Richard B; Fromm Herbert J
Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance.
The Journal of biological chemistry 2003;278(9):6673-9.
2002: Iancu Cristina V; Borza Tudor; Fromm Herbert J; Honzatko Richard B
Feedback inhibition and product complexes of recombinant mouse muscle adenylosuccinate synthetase.
The Journal of biological chemistry 2002;277(43):40536-43.
2002: Iancu Cristina V; Borza Tudor; Fromm Herbert J; Honzatko Richard B
IMP, GTP, and 6-phosphoryl-IMP complexes of recombinant mouse muscle adenylosuccinate synthetase.
The Journal of biological chemistry 2002;277(30):26779-87.
2002: Nelson Scott W; Honzatko Richard B; Fromm Herbert J
Hybrid tetramers of porcine liver fructose-1,6-bisphosphatase reveal multiple pathways of allosteric inhibition.
The Journal of biological chemistry 2002;277(18):15539-45.
2002: Gorrell Andrea; Wang Wenyan; Underbakke Eric; Hou Zhenglin; Honzatko Richard B; Fromm Herbert J
Determinants of L-aspartate and IMP recognition in Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 2002;277(11):8817-21.
2002: Hou Zhenglin; Wang Wenyan; Fromm Herbert J; Honzatko Richard B
IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
The Journal of biological chemistry 2002;277(8):5970-6.
2001: Wen J; Nelson S W; Honzatko R B; Fromm H J; Petrich J W
Environment of tryptophan 57 in porcine fructose-1,6-bisphosphatase studied by time-resolved fluorescence and site-directed mutagenesis.
Photochemistry and photobiology 2001;74(5):679-85.
2001: Iancu C V; Borza T; Choe J Y; Fromm H J; Honzatko R B
Recombinant mouse muscle adenylosuccinate synthetase: overexpression, kinetics, and crystal structure.
The Journal of biological chemistry 2001;276(45):42146-52.
2001: Nelson S W; Honzatko R B; Fromm H J
Spontaneous subunit exchange in porcine liver fructose-1,6-bisphosphatase.
FEBS letters 2001;492(3):254-8.
2001: Nelson S W; Kurbanov F T; Honzatko R B; Fromm H J
The N-terminal segment of recombinant porcine fructose-1,6-bisphosphatase participates in the allosteric regulation of catalysis.
The Journal of biological chemistry 2001;276(9):6119-24.
2000: Nelson S W; Iancu C V; Choe J Y; Honzatko R B; Fromm H J
Tryptophan fluorescence reveals the conformational state of a dynamic loop in recombinant porcine fructose-1,6-bisphosphatase.
Biochemistry 2000;39(36):11100-6.
2000: Nelson S W; Choe J Y; Honzatko R B; Fromm H J
Mutations in the hinge of a dynamic loop broadly influence functional properties of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2000;275(39):29986-92.
2000: Choe J Y; Fromm H J; Honzatko R B
Crystal structures of fructose 1,6-bisphosphatase: mechanism of catalysis and allosteric inhibition revealed in product complexes.
Biochemistry 2000;39(29):8565-74.
2000: Aleshin A E; Kirby C; Liu X; Bourenkov G P; Bartunik H D; Fromm H J; Honzatko R B
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
Journal of molecular biology 2000;296(4):1001-15.
1999: Lee P; Gorrell A; Fromm H J; Colman R F
8-(4-Bromo-2,3-dioxobutylthio)guanosine 5'-triphosphate: a new affinity label for purine nucleotide sites in proteins.
Archives of biochemistry and biophysics 1999;372(1):205-13.
1999: Liu X; Kim C S; Kurbanov F T; Honzatko R B; Fromm H J
Dual mechanisms for glucose 6-phosphate inhibition of human brain hexokinase.
The Journal of biological chemistry 1999;274(44):31155-9.
1999: Honzatko R B; Fromm H J
Structure-function studies of adenylosuccinate synthetase from Escherichia coli.
Archives of biochemistry and biophysics 1999;370(1):1-8.
1999: Aleshin A E; Malfois M; Liu X; Kim C S; Fromm H J; Honzatko R B; Koch M H; Svergun D I
Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution.
Biochemistry 1999;38(26):8359-66.
1999: Hou Z; Cashel M; Fromm H J; Honzatko R B
Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1999;274(25):17505-10.
1999: Choe J Y; Poland B W; Fromm H J; Honzatko R B
Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.
Biochemistry 1999;38(21):6953-61.
1999: Lee P; Gorrell A; Fromm H J; Colman R F
Implication of arginine-131 and arginine-303 in the substrate site of adenylosuccinate synthetase of Escherichia coli by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate.
Biochemistry 1999;38(18):5754-63.
1999: Honzatko R B; Stayton M M; Fromm H J
Adenylosuccinate synthetase: recent developments.
Advances in enzymology and related areas of molecular biology 1999;73():57-102, ix-x.
1998: Aleshin A E; Zeng C; Bartunik H D; Fromm H J; Honzatko R B
Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
Journal of molecular biology 1998;282(2):345-57.
1998: Aleshin A E; Fromm H J; Honzatko R B
Multiple crystal forms of hexokinase I: new insights regarding conformational dynamics, subunit interactions, and membrane association.
FEBS letters 1998;434(1-2):42-6.
1998: Choe J Y; Poland B W; Fromm H J; Honzatko R B
Role of a dynamic loop in cation activation and allosteric regulation of recombinant porcine fructose-1,6-bisphosphatase.
Biochemistry 1998;37(33):11441-50.
1998: Fang T Y; Alechina O; Aleshin A E; Fromm H J; Honzatko R B
Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase.
The Journal of biological chemistry 1998;273(31):19548-53.
1998: Kurbanov F T; Choe J Y; Honzatko R B; Fromm H J
Directed mutations in the poorly defined region of porcine liver fructose-1,6-bisphosphatase significantly affect catalysis and the mechanism of AMP inhibition.
The Journal of biological chemistry 1998;273(28):17511-6.
1998: Wang W; Gorrell A; Hou Z; Honzatko R B; Fromm H J
Ambiguities in mapping the active site of a conformationally dynamic enzyme by directed mutation. Role of dynamics in structure-function correlations in Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1998;273(26):16000-4.
1998: Aleshin A E; Zeng C; Bourenkov G P; Bartunik H D; Fromm H J; Honzatko R B
The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure (London, England : 1993) 1998;6(1):39-50.
1998: Zeng C; Aleshin A E; Chen G; Honzatko R B; Fromm H J
The roles of glycine residues in the ATP binding site of human brain hexokinase.
The Journal of biological chemistry 1998;273(2):700-4.
1997: Shyur L F; Poland B W; Honzatko R B; Fromm H J
Major changes in the kinetic mechanism of AMP inhibition and AMP cooperativity attend the mutation of Arg49 in fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1997;272(42):26295-9.
1997: Wang W; Hou Z; Honzatko R B; Fromm H J
Relationship of conserved residues in the IMP binding site to substrate recognition and catalysis in Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1997;272(27):16911-6.
1997: Poland B W; Bruns C; Fromm H J; Honzatko R B
Entrapment of 6-thiophosphoryl-IMP in the active site of crystalline adenylosuccinate synthetase from Escherichia coli.
The Journal of biological chemistry 1997;272(24):15200-5.
1997: Kang C; Sun N; Poland B W; Gorrell A; Honzatko R B; Fromm H J
Residues essential for catalysis and stability of the active site of Escherichia coli adenylosuccinate synthetase as revealed by directed mutation and kinetics.
The Journal of biological chemistry 1997;272(18):11881-5.
1997: Wang W; Gorrell A; Honzatko R B; Fromm H J
A study of Escherichia coli adenylosuccinate synthetase association states and the interface residues of the homodimer.
The Journal of biological chemistry 1997;272(11):7078-84.
1996: Poland B W; Fromm H J; Honzatko R B
Crystal structures of adenylosuccinate synthetase from Escherichia coli complexed with GDP, IMP hadacidin, NO3-, and Mg2+.
Journal of molecular biology 1996;264(5):1013-27.
1996: Shyur L F; Aleshin A E; Honzatko R B; Fromm H J
Biochemical properties of mutant and wild-type fructose-1,6-bisphosphatases are consistent with the coupling of intra- and intersubunit conformational changes in the T- and R-state transition.
The Journal of biological chemistry 1996;271(52):33301-7.
1996: Poland B W; Lee S F; Subramanian M V; Siehl D L; Anderson R J; Fromm H J; Honzatko R B
Refined crystal structure of adenylosuccinate synthetase from Escherichia coli complexed with hydantocidin 5'-phosphate, GDP, HPO4(2-), Mg2+, and hadacidin.
Biochemistry 1996;35(49):15753-9.
1996: Kang C; Kim S; Fromm H J
Subunit complementation of Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1996;271(47):29722-8.
1996: Zeng C; Aleshin A E; Hardie J B; Harrison R W; Fromm H J
ATP-binding site of human brain hexokinase as studied by molecular modeling and site-directed mutagenesis.
Biochemistry 1996;35(40):13157-64.
1996: Aleshin A E; Zeng C; Fromm H J; Honzatko R B
Crystallization and preliminary X-ray analysis of human brain hexokinase.
FEBS letters 1996;391(1-2):9-10.
1996: Moe O A; Baker-Malcolm J F; Wang W; Kang C; Fromm H J; Colman R F
Involvement of arginine 143 in nucleotide substrate binding at the active site of adenylosuccinate synthetase from Escherichia coli.
Biochemistry 1996;35(28):9024-33.
1996: Poland B W; Hou Z; Bruns C; Fromm H J; Honzatko R B
Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
The Journal of biological chemistry 1996;271(26):15407-13.
1996: Shyur L F; Aleshin A E; Fromm H J
A study of subunit interface residues of fructose-1,6-bisphosphatase by site-directed mutagenesis: effects on AMP and Mg2+ affinities.
Biochemistry 1996;35(23):7492-8.
1996: Zhang R; Villeret V; Lipscomb W N; Fromm H J
Kinetics and mechanisms of activation and inhibition of porcine liver fructose-1,6-bisphosphatase by monovalent cations.
Biochemistry 1996;35(9):3038-43.
1996: Shyur L F; Aleshin A E; Honzatko R B; Fromm H J
Site-directed mutagenesis of residues at subunit interfaces of porcine fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1996;271(6):3005-10.
1995: Silva M M; Poland B W; Hoffman C R; Fromm H J; Honzatko R B
Refined crystal structures of unligated adenylosuccinate synthetase from Escherichia coli.
Journal of molecular biology 1995;254(3):431-46.
1995: Villeret V; Huang S; Fromm H J; Lipscomb W N
Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8916-20.
1995: Kang C; Fromm H J
Identification of an essential second metal ion in the reaction mechanism of Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1995;270(26):15539-44.
1995: Zhang R; Fromm H J
Mutation of arginine 276 to methionine changes Mg2+ cooperativity and the kinetic mechanism of fructose-1,6-bisphosphatase.
Biochemistry 1995;34(25):8190-5.
1995: Wang W; Poland B W; Honzatko R B; Fromm H J
Identification of arginine residues in the putative L-aspartate binding site of Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1995;270(22):13160-3.
1995: Shyur L F; Zhang R; Fromm H J
Site-directed mutagenesis of the substrate binding site of porcine fructose-1,6-bisphosphatase.
Archives of biochemistry and biophysics 1995;319(1):123-7.
1995: Zeng C; Fromm H J
Active site residues of human brain hexokinase as studied by site-specific mutagenesis.
The Journal of biological chemistry 1995;270(18):10509-13.
1995: Zhang R; Chen L; Villeret V; Fromm H J
Glycine 122 is essential for cooperativity and binding of Mg2+ to porcine fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1995;270(1):54-8.
1994: Kang C; Sun N; Honzatko R B; Fromm H J
Replacement of Asp333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5'-triphosphate to xanthosine 5'-triphosphate.
The Journal of biological chemistry 1994;269(39):24046-9.
1994: Kang C; Fromm H J
Characterization of the putative GTP-binding site residues of Escherichia coli adenylosuccinate synthetase by site-directed mutagenesis.
Archives of biochemistry and biophysics 1994;310(2):475-80.
1994: Chen M; Chen L; Fromm H J
Replacement of glutamic acid 29 with glutamine leads to a loss of cooperativity for AMP with porcine fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1994;269(8):5554-8.
1993: Chen L; Hegde R; Chen M; Fromm H J
Site-specific mutagenesis of the metal binding sites of porcine fructose-1,6-bisphosphatase.
Archives of biochemistry and biophysics 1993;307(2):350-4.
1993: Burton V A; Chen M; Ong W C; Ling T; Fromm H J; Stayton M M
High-level expression of porcine fructose-1,6-bisphosphatase in Escherichia coli: purification and characterization of the enzyme.
Biochemical and biophysical research communications 1993;192(2):511-7.
1992: Liu F; Dong Q; Fromm H J
Site-directed mutagenesis of the phosphate-binding consensus sequence in Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1992;267(4):2388-92.
1991: Soans C; Fromm H J
Studies of ligand binding to Escherichia coli adenylosuccinate synthetase.
Archives of biochemistry and biophysics 1991;291(1):107-12.
1991: Dong Q; Liu F; Myers A M; Fromm H J
Evidence for an arginine residue at the substrate binding site of Escherichia coli adenylosuccinate synthetase as studied by chemical modification and site-directed mutagenesis.
The Journal of biological chemistry 1991;266(19):12228-33.
1991: Liu F; Fromm H J
31P nuclear magnetic resonance spectroscopy studies of substrate and product binding to fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1991;266(18):11774-8.
1991: Liu F; Dong Q; Myers A M; Fromm H J
Expression of human brain hexokinase in Escherichia coli: purification and characterization of the expressed enzyme.
Biochemical and biophysical research communications 1991;177(1):305-11.
1990: Liu F; Fromm H J
Kinetic studies on the mechanism and regulation of rabbit liver fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1990;265(13):7401-6.
1990: Dong Q; Fromm H J
Chemical modification of adenylosuccinate synthetase from Escherichia coli by pyridoxal 5'-phosphate. Identification of an active site lysyl residue.
The Journal of biological chemistry 1990;265(11):6235-40.
1990: Dong Q; Soans C; Liu F; Fromm H J
Identification of different classes of nonessential sulfhydryl groups in Escherichia coli adenylosuccinate synthetase.
Archives of biochemistry and biophysics 1990;276(1):77-84.
1989: Liu F; Fromm H J
Investigation of the relationship between tyrosyl residues and the adenosine 5'-monophosphate binding site of rabbit liver fructose-1,6-biphosphatase as studied by chemical modification and nuclear magnetic resonance spectroscopy.
The Journal of biological chemistry 1989;264(31):18320-5.
1989: Liu F; Roy M; Fromm H J
The site of substrate and fructose 2,6-bisphosphate binding to rabbit liver fructose-1,6-bisphosphatase.
Biochemical and biophysical research communications 1989;161(2):689-95.
1988: Liu F; Fromm H J
Relationship between thiol group modification and the binding site for fructose 2,6-bisphosphate on rabbit liver fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1988;263(20):10035-9.
1988: Liu F; Fromm H J
Interaction of fructose 2,6-bisphosphate and AMP with fructose-1,6-bisphosphatase as studied by nuclear magnetic resonance spectroscopy.
The Journal of biological chemistry 1988;263(19):9122-8.
1988: Serra M A; Bass M B; Fromm H J; Honzatko R B
Preliminary X-ray crystallographic study of adenylosuccinate synthetase from Escherichia coli.
Journal of molecular biology 1988;200(4):753-4.
1988: Liu F; Fromm H J
Purification and characterization of fructose-1,6-bisphosphatase from bovine brain.
Archives of biochemistry and biophysics 1988;260(2):609-15.
1987: Bass M B; Fromm H J
Is rat skeletal muscle hexokinase an allosteric enzyme?
Archives of biochemistry and biophysics 1987;256(2):708-11.
1987: Bass M B; Fromm H J; Stayton M M
Overproduction, purification, and characterization of adenylosuccinate synthetase from Escherichia coli.
Archives of biochemistry and biophysics 1987;256(1):335-42.
1985: Bass M B; Fromm H J
trans-1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic acid is superior to ethylenediamine-N,N,N',N'-tetraacetic acid for sequestering Mg2+ in 31P NMR experiments involving ATP spectra at neutral and acidic pH.
Analytical biochemistry 1985;145(2):292-301.
1984: Bass M B; Fromm H J; Rudolph F B
The mechanism of the adenylosuccinate synthetase reaction as studied by positional isotope exchange.
The Journal of biological chemistry 1984;259(20):12330-3.
1983: Stayton M M; Rudolph F B; Fromm H J
Regulation, genetics, and properties of adenylosuccinate synthetase: a review.
Current topics in cellular regulation 1983;22():103-41.

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