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Clara Fronticelli

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Clara Fronticelli; Raymond C Koehler
Design of recombinant hemoglobins for use in transfusion fluids.
Raymond C Koehler; Clara Fronticelli; Enrico Bucci
Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers.
Clara Fronticelli; Raymond C Koehler; William S Brinigar
Recombinant hemoglobins as artificial oxygen carriers.

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All Publications

2009: Clara Fronticelli; Raymond C Koehler
Design of recombinant hemoglobins for use in transfusion fluids.
Critical care clinics 2009;25(2):357-71, Table of Contents.
2008: Raymond C Koehler; Clara Fronticelli; Enrico Bucci
Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers.
Biochimica et biophysica acta 2008;1784(10):1387-94.
2007: Clara Fronticelli; Raymond C Koehler; William S Brinigar
Recombinant hemoglobins as artificial oxygen carriers.
Artificial cells, blood substitutes, and immobilization biotechnology 2007;35(1):45-52.
2006: Masaaki Nemoto; Toshiaki Mito; William S Brinigar; Clara Fronticelli; Raymond C Koehler
Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouse.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(5):1688-91.
2004: Randal O Dull; Bracken J Dewitt; Ramani Dinavahi; Larry Schwartz; Christopher Hubert; Nathan Pace; Clara Fronticelli
Quantitative assessment of hemoglobin-induced endothelial barrier dysfunction.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(5):1930-7.
2003: Kevin M Bobofchak; Toshiaki Mito; Sarah J Texel; Andrea Bellelli; Masaaki Nemoto; Richard J Traystman; Raymond C Koehler; William S Brinigar; Clara Fronticelli
A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporter.
American journal of physiology. Heart and circulatory physiology 2003;285(2):H549-61.
2002: Clara Fronticelli; Kevin M Bobofchak; Michael Karavitis; Maria Teresa Sanna; William S Brinigar
Introduction of a new regulatory mechanism into human hemoglobin.
Biophysical chemistry 2002;98(1-2):115-26.
2001: M C Piro; Valeria Militello; Maurizio Leone; Zygmunt Gryczynski; Stanley V Smith; William S Brinigar; Antonio Cupane; Fred Friedman; Clara Fronticelli
Heme pocket disorder in myoglobin: reversal by acid-induced soft refolding.
Biochemistry 2001;40(39):11841-50.
2001: Clara Fronticelli; Daniele Arosio; Kevin M Bobofchak; GB Vasquez
Molecular engineering of a polymer of tetrameric hemoglobins.
Proteins 2001;44(3):212-22.
2001: M R Mihailescu; Clara Fronticelli; Irina M Russu
Allosteric free energy changes at the alpha 1 beta 2 interface of human hemoglobin probed by proton exchange of Trp beta 37.
Proteins 2001;44(2):73-8.
2001: Maurizio Gattoni; M C Piro; Alberto Boffi; William S Brinigar; Clara Fronticelli; Emilia Chiancone
The heme-globin and dimerization equilibria of recombinant human hemoglobins carrying site-specific beta chains mutations.
Archives of biochemistry and biophysics 2001;386(2):172-8.
1999: Gregory B Vásquez; Michael Karavitis; X Ji; Igor Pechik; William S Brinigar; Gary L Gilliland; Clara Fronticelli
Cysteines beta93 and beta112 as probes of conformational and functional events at the human hemoglobin subunit interfaces.
Biophysical journal 1999;76(1 Pt 1):88-97.
1998: Michael Karavitis; Clara Fronticelli; William S Brinigar; GB Vasquez; Valeria Militello; Maurizio Leone; Antonio Cupane
Properties of human hemoglobins with increased polarity in the alpha- or beta-heme pocket. Carbonmonoxy derivatives.
The Journal of biological chemistry 1998;273(37):23740-9.
1998: Gregory B Vásquez; X Ji; Clara Fronticelli; Gary L Gilliland
Human carboxyhemoglobin at 2.2 A resolution: structure and solvent comparisons of R-state, R2-state and T-state hemoglobins.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 3):355-66.
1998: X Ji; M Braxenthaler; John Moult; Clara Fronticelli; Enrico Bucci; Gary L Gilliland
Conformation of the sebacyl beta1Lys82-beta2Lys82 crosslink in T-state human hemoglobin.
Proteins 1998;30(3):309-20.
1998: X Ji; Michael Karavitis; A Razynska; Herman Kwansa; Gregory B Vásquez; Clara Fronticelli; Enrico Bucci; Gary L Gilliland
Alpha-subunit oxidation in T-state crystals of a sebacyl cross-linked human hemoglobin with unusual autoxidation properties.
Biophysical chemistry 1998;70(1):21-34.
1997: Antonio Cupane; Maurizio Leone; Valeria Militello; Fred Friedman; Aditya Koley; GB Vasquez; William S Brinigar; Michael Karavitis; Clara Fronticelli
Modification of alpha-chain or beta-chain heme pocket polarity by Val(E11) --> thr substitution has different effects on the steric, dynamic, and functional properties of human recombinant hemoglobin. Deoxy derivatives.
The Journal of biological chemistry 1997;272(42):26271-8.
1997: M Thomas; B Matheson-Urbaitis; Herman Kwansa; Enrico Bucci; Clara Fronticelli
Introduction of negative charges to a crosslinked hemoglobin: lack of effect on plasma half time.
Artificial cells, blood substitutes, and immobilization biotechnology 1997;25(3):309-14.
1997: M T Sanna; A Razynska; Michael Karavitis; Aditya Koley; Fred Friedman; Irina M Russu; William S Brinigar; Clara Fronticelli
Assembly of human hemoglobin. Studies with Escherichia coli-expressed alpha-globin.
The Journal of biological chemistry 1997;272(6):3478-86.
1996: Enrico Bucci; A Razynska; Herman Kwansa; Zygmunt Gryczynski; J H Collins; Clara Fronticelli; Ron Unger; M Braxenthaler; John Moult; X Ji; Gary L Gilliland
Positive and negative cooperativities at subsequent steps of oxygenation regulate the allosteric behavior of multistate sebacylhemoglobin.
Biochemistry 1996;35(11):3418-25.
1996: I Pechik; X Ji; Krzysztof Fidelis; Michael Karavitis; John Moult; William S Brinigar; Clara Fronticelli; Gary L Gilliland
Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin.
Biochemistry 1996;35(6):1935-45.
1996: A Razynska; B Matheson-Urbaitis; Clara Fronticelli; J H Collins; Enrico Bucci
Stabilization of the tetrameric structure of human and bovine hemoglobins by pseudocrosslinking with muconic acid.
Archives of biochemistry and biophysics 1996;326(1):119-25.
1995: Clara Fronticelli; M T Sanna; G C Perez-Alvarado; Michael Karavitis; A-Lien Lu-Chang; William S Brinigar
Allosteric modulation by tertiary structure in mammalian hemoglobins. Introduction of the functional characteristics of bovine hemoglobin into human hemoglobin by five amino acid substitutions.
The Journal of biological chemistry 1995;270(51):30588-92.
1995: B Matheson-Urbaitis; Y S Lu; Clara Fronticelli; Enrico Bucci
Renal and systemic-hemodynamic response to isovolemic exchange transfusion with hemoglobin cross-linked with bis (3,5-dibromosalicyl) fumarate or albumin.
The Journal of laboratory and clinical medicine 1995;126(3):250-60.
1995: Valeria Militello; Antonio Cupane; Maurizio Leone; William S Brinigar; A-Lien Lu-Chang; Clara Fronticelli
Dynamic properties of some beta-chain mutant hemoglobins.
Proteins 1995;22(1):12-9.
1995: Emilia Chiancone; Maurizio Gattoni; Clara Fronticelli; A Termine; L Silvestri; Paolo Sarti
Preparative and analytical applications of immobilized haemoglobin.
Journal of chromatography. B, Biomedical applications 1995;664(1):89-95.
1994: Clara Fronticelli; I Pechik; William S Brinigar; J Kowalczyk; Gary L Gilliland
Chloride ion independence of the Bohr effect in a mutant human hemoglobin beta (V1M+H2deleted).
The Journal of biological chemistry 1994;269(39):23965-9.
1994: Clara Fronticelli; Maurizio Gattoni; A-Lien Lu-Chang; William S Brinigar; J L Bucci; Emilia Chiancone
The dimer-tetramer equilibrium of recombinant hemoglobins. Stabilization of the alpha 1 beta 2 interface by the mutation beta(Cys112-->Gly) at the alpha 1 beta 1 interface.
Biophysical chemistry 1994;51(1):53-7.
1994: Clara Fronticelli; Enrico Bucci
Conformational and functional characteristics of bovine hemoglobin.
Methods in enzymology 1994;231():150-63.
1993: Zygmunt Gryczynski; Clara Fronticelli; T Tenenholz; Enrico Bucci
Effect of disordered hemes on energy transfer rates between tryptophans and heme in myoglobin.
Biophysical journal 1993;65(5):1951-8.
1993: Enrico Bucci; Clara Fronticelli; Zygmunt Gryczynski; A Razynska; J H Collins
Effect of intramolecular cross-links on the enthalpy and quaternary structure of the intermediates of oxygenation of human hemoglobin.
Biochemistry 1993;32(14):3519-26.
1993: Clara Fronticelli; William S Brinigar; J S Olson; Enrico Bucci; Zygmunt Gryczynski; J K O'Donnell; J Kowalczyk
Recombinant human hemoglobin: modification of the polarity of the beta-heme pocket by a valine67(E11)-->threonine mutation.
Biochemistry 1993;32(5):1235-42.
1992: B Urbaitis; Y S Lu; Clara Fronticelli; Enrico Bucci
Renal excretion of pseudo-cross-linked human, porcine and bovine hemoglobins.
Biochimica et biophysica acta 1992;1156(1):50-6.
1992: Emilia Chiancone; Clara Fronticelli; Maurizio Gattoni; B K Urbaitis; Enrico Bucci
Immobilized hemoglobin in the purification of hemoglobin-based oxygen carriers.
Journal of chromatography 1992;604(1):117-23.
1992: Enrico Bucci; Clara Fronticelli
Hemoglobin as oxygen carrier in cell-free fluids.
Maryland medical journal (Baltimore, Md. : 1985) 1992;41(6):527-31.
1992: Enrico Bucci; Clara Fronticelli; A Razynska; Valeria Militello; Raymond C Koehler; B Urbaitis
Hemoglobin tetramers stabilized with polyaspirins.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology 1992;20(2-4):243-52.
1991: Clara Fronticelli; J K O'Donnell; William S Brinigar
Recombinant human hemoglobin: expression and refolding of beta-globin from Escherichia coli.
Journal of protein chemistry 1991;10(5):495-501.
1991: Enrico Bucci; Clara Fronticelli; Zygmunt Gryczynski
Discontinuous release of heat at successive steps of oxygenation in human and bovine hemoglobin at pH 9.0.
Biochemistry 1991;30(13):3195-9.
1991: B K Urbaitis; A Razynska; Q Corteza; Clara Fronticelli; Enrico Bucci
Intravascular retention and renal handling of purified natural and intramolecularly cross-linked hemoglobins.
The Journal of laboratory and clinical medicine 1991;117(2):115-21.
1990: Clara Fronticelli; Enrico Bucci; A Razynska; J Sznajder; B Urbaitis; Zygmunt Gryczynski
Bovine hemoglobin pseudo-crosslinked with mono(3,5-dibromosalicyl)-fumarate.
European journal of biochemistry / FEBS 1990;193(2):331-6.
1990: A Razynska; Clara Fronticelli; E Di Cera; Zygmunt Gryczynski; Enrico Bucci
Effect of temperature on oxygen affinity and anion binding of bovine hemoglobin.
Biophysical chemistry 1990;38(1-2):111-5.
1990: Clara Fronticelli
A possible new mechanism of oxygen affinity modulation in mammalian hemoglobins.
Biophysical chemistry 1990;37(1-3):141-6.
1989: Clara Fronticelli; Enrico Bucci; Henryk Malak
Local phenomena and distribution of molecular species during the unfolding of heme-free myoglobin in the presence of GdnHCl and urea as seen by time-resolved fluorescence spectroscopy.
Biophysical chemistry 1989;33(2):143-51.
1989: Enrico Bucci; A Razynska; B Urbaitis; Clara Fronticelli
Pseudo cross-link of human hemoglobin with mono-(3,5-dibromosalicyl)fumarate.
The Journal of biological chemistry 1989;264(11):6191-5.
1988: Enrico Bucci; Henryk Malak; Clara Fronticelli; Ignacy Gryczynski; G Laczko; Joseph R Lakowicz
Time-resolved emission spectra of hemoglobin on the picosecond time scale.
Biophysical chemistry 1988;32(2-3):187-98.
1988: Clara Fronticelli; Enrico Bucci; A Razynska
Modulation of oxygen affinity in hemoglobin by solvent components. Interaction of bovine hemoglobin with 2,3-diphosphoglycerate and monatomic anions.
Journal of molecular biology 1988;202(2):343-48.
1988: Enrico Bucci; Henryk Malak; Clara Fronticelli; Ignacy Gryczynski; Joseph R Lakowicz
Resolution of the lifetimes and correlation times of the intrinsic tryptophan fluorescence of human hemoglobin solutions using 2 GHz frequency-domain fluorometry.
The Journal of biological chemistry 1988;263(15):6972-7.
1988: Enrico Bucci; Clara Fronticelli; C Orth; M C Martorana; L Aebischer; P Angeloni
Bovine hemoglobin as a basis for artificial oxygen carriers.
Biomaterials, artificial cells, and artificial organs 1988;16(1-3):197-204.
1986: M Sassaroli; Clara Fronticelli; J Kowalczick; E Bucci; Adil E Shamoo
Librational motions of membrane-embedded Ca2+-ATPase of sarcoplasmic reticulum labeled with fluorescein isothiocyanate.
Biophysical chemistry 1986;25(3):283-6.
1986: Clara Fronticelli; T Sato; C Orth; Enrico Bucci
Bovine hemoglobin as a potential source of hemoglobin-based oxygen carriers: crosslinking with bis(2,3-dibromosalycyl)fumarate.
Biochimica et biophysica acta 1986;874(1):76-81.
1986: Clara Fronticelli; Enrico Bucci; A Zachary; Barry P Rosen
Conformational properties of membrane-bound fumarate reductase of Escherichia coli.
Archives of biochemistry and biophysics 1986;249(2):579-87.
1986: B Campbell; Clara Fronticelli; A Zachary; Enrico Bucci
Gelling properties of apohemoglobin S alone and in mixtures with hemoglobin S.
The Journal of biological chemistry 1986;261(9):3931-3.
1985: Clara Fronticelli; Enrico Bucci
Circular dichroism kinetics of acid denaturation of hemoglobin and of its beta-subunits.
Biophysical chemistry 1985;23(1-2):125-8.
1985: Enrico Bucci; Clara Fronticelli
Anion Bohr effect of human hemoglobin.
Biochemistry 1985;24(2):371-6.
1984: Clara Fronticelli; Enrico Bucci; C Orth
Solvent regulation of oxygen affinity in hemoglobin. Sensitivity of bovine hemoglobin to chloride ions.
The Journal of biological chemistry 1984;259(17):10841-4.
1984: M Sassaroli; Enrico Bucci; J Liesegang; Clara Fronticelli; R F Steiner
Specialized functional domains in hemoglobin: dimensions in solution of the apohemoglobin dimer labeled with fluorescein iodoacetamide.
Biochemistry 1984;23(11):2487-91.
1984: Clara Fronticelli; Enrico Bucci; Adil E Shamoo
Solvent perturbation evidence for a two-state system regulated by calcium in sarcoplasmic reticulum ATPase.
Biophysical chemistry 1984;19(3):255-8.
1983: Clara Fronticelli; Enrico Bucci; N Higgins; M Sassaroli; J Kowalczyk
Neohemoglobins as blood substitutes.
Progress in clinical and biological research 1983;122():51-7.
1982: D Franchi; Clara Fronticelli; Enrico Bucci
Folding domains as functional tools in allosteric systems: a heme-dependent domain in hemoglobin beta subunits.
Biochemistry 1982;21(24):6181-7.
1981: T Watanabe; D Lewis; R Nakamoto; M Kurzmack; Clara Fronticelli; Giuseppe Inesi
Modulation of calcium binding in sarcoplasmic reticulum adenosinetriphosphatase.
Biochemistry 1981;20(23):6617-25.
1981: J Oton; Enrico Bucci; R F Steiner; Clara Fronticelli; D Franchi; J Montemarano; A Martinez
Molecular dynamics of hemoglobin subunits as seen by fluorescence spectroscopy.
The Journal of biological chemistry 1981;256(14):7248-56.
1981: Enrico Bucci; Clara Fronticelli
Measurement of the Bohr effect: dependence on pH of oxygen affinity of hemoglobin.
Methods in enzymology 1981;76():523-33.
1980: H P Scholberg; Clara Fronticelli; Enrico Bucci
Conformational changes in the hemoglobin S system as seen by proton binding.
The Journal of biological chemistry 1980;255(18):8592-8.
1979: Enrico Bucci; Clara Fronticelli; J Nicklas; S Charache
Conformation in solution of hemoglobin Osler (alpha 2 A beta 2 145 Tyr replaced by Asp).
The Journal of biological chemistry 1979;254(21):10811-9.
1978: Clara Fronticelli
Effect of the beta6 Glu replaced by Val mutation on the optical activity of hemoglobin S and of its beta subunits.
The Journal of biological chemistry 1978;253(7):2288-91.
1976: Clara Fronticelli; R Gold
Conformational relevance of the beta6Glu replaced by Val mutation in the beta subunits and in the beta(1-55) and beta(1-30) peptides of hemoglobin S.
The Journal of biological chemistry 1976;251(16):4968-72.
1971: Enrico Bucci; Clara Fronticelli
The hemichromogen form of the isolated subunits of hemoglobin.
Biochimica et biophysica acta 1971;243(2):170-7.
1968: Enrico Bucci; Clara Fronticelli; B Ragatz
The proton-binding behavior of human hemoglobin and its subunits in their native state.
The Journal of biological chemistry 1968;243(2):241-9.
1966: E Antonini; Enrico Bucci; Clara Fronticelli; Emilia Chiancone; J Wyman; A Rossi-Fanelli
The properties and interactions of the isolated alpha- and beta-chains of human haemoglobin. V. The reaction of alpha- and beta-chains.
Journal of molecular biology 1966;17(1):29-46.
1966: M Reichlin; Enrico Bucci; Clara Fronticelli; J Wyman; E Antonini; C Ioppolo; A Rossi-Fanelli
The properties and interactions of the isolated alpha- and beta-chains of human haemoglobin. IV. Immunological studies involving antibodies against the isolated chains.
Journal of molecular biology 1966;17(1):18-28.
1965: M Reichlin; Enrico Bucci; Clara Fronticelli; J Wyman; A Rossi-Fanelli; E Antonini
Properties and interactions of the isolated alpha and beta chains of human haemoglobin. II. Immunochemical behaviour of the chains: fractionation of an antigen.
Journal of molecular biology 1965;12(3):774-9.
1965: E Antonini; J Wyman; Enrico Bucci; Clara Fronticelli; M Brunori; M Reichlin; A R Fanelli
The oxygen equilibrium of the hybrids of canine and human haemoglobin.
Biochimica et biophysica acta 1965;104(1):160-6.
1965: E ANTONINI; Enrico Bucci; Clara Fronticelli; J WYMAN; A ROSSI-FANELLI
THE PROPERTIES AND INTERACTIONS OF THE ISOLATED ALPHA AND BETA CHAINS OF HUMAN HAEMOGLOBIN. 3. OBSERVATIONS ON THE EQUILIBRIA AND KINETICS OF THE REACTIONS WITH GASES.
Journal of molecular biology 1965;12():375-84.
1965: Enrico Bucci; Clara Fronticelli; Emilia Chiancone; J WYMAN; E ANTONINI; A ROSSI-FANELLI
THE PROPERTIES AND INTERACTIONS OF THE ISOLATER ALPHA AND BETA CHAINS OF HUMAN HAEMOGLOBIN. I. SEDIMENTATION AND ELECTROPHORETIC BEHAVIOUR.
Journal of molecular biology 1965;12():183-92.
1965: E ANTONINI; J WYMAN; M BRUNORI; Clara Fronticelli; Enrico Bucci; A ROSSI-FANELLI
STUDIES ON THE RELATIONS BETWEEN MOLECULAR AND FUNCTIONAL PROPERTIES OF HEMOGLOBIN. V. THE INFLUENCE OF TEMPERATURE ON THE BOHR EFFECT IN HUMAN AND IN HORSE HEMOGLOBIN.
The Journal of biological chemistry 1965;240():1096-103.
1965: Enrico Bucci; Clara Fronticelli; N DANCE; E M SHOOTER
FURTHER STUDIES ON THE STRUCTURE AND PROPERTIES OF HUMAN HAEMOGLOBINS MODIFIED BY DIGESTION WITH THE CARBOXYPEPTIDASES.
Journal of molecular biology 1965;11():109-15.
1965: Enrico Bucci; Clara Fronticelli
A NEW METHOD FOR THE PREPARATION OF ALPHA AND BETA SUBUNITS OF HUMAN HEMOGLOBIN.
The Journal of biological chemistry 1965;240():PC551-2.
1964: E ANTONINI; J WYMAN; M BRUNORI; Clara Fronticelli; Enrico Bucci; M REICHLIN; A R FANELLI
THE OXYGEN BOHR EFFECT OF HUMAN FETAL HEMOGLOBIN.
Archives of biochemistry and biophysics 1964;108():569-72.
1963: Clara Fronticelli; Enrico Bucci
ACETONE EXTRACTION OF HEME FROM MYOGLOBIN AND HEMOGLOBIN AT ACID PH.
Biochimica et biophysica acta 1963;78():530-1.
1963: E ANTONINI; J WYMAN; M BRUNORI; Enrico Bucci; Clara Fronticelli; A ROSSI-FANELLI
STUDIES ON THE RELATIONS BETWEEN MOLECULAR AND FUNCTIONAL PROPERTIES OF HEMOGLOBIN. IV. THE BOHR EFFECT IN HUMAN HEMOGLOBIN MEASURED BY PROTON BINDING.
The Journal of biological chemistry 1963;238():2950-7.
1963: Enrico Bucci; Clara Fronticelli; I BELLELLI; E ANTONINI; J WYMAN; A R FANELLI
Studies on acetylated human hemoglobin.
Archives of biochemistry and biophysics 1963;100():364-88.
1962: E ANTONINI; J WYMAN; Enrico Bucci; Clara Fronticelli; A ROSSI-FANELLI
The dissociation and recombination of subunits of human, horse, and canine hemoglobin.
Journal of molecular biology 1962;4():368-75.
1961: Enrico Bucci; Clara Fronticelli
[Spectrophotometric stability of human fetal and bovine adult hemoglobins between pH3 and 6].
Bollettino della Società italiana di biologia sperimentale 1961;37():1768-71.
1961: Enrico Bucci; Clara Fronticelli
[Spectrophotometric characteristics of hemoglobin and myoglobin of the tunny].
Bollettino della Società italiana di biologia sperimentale 1961;37():1765-8.