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David Frost

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Xuesong Liu; Joann Palma; Robert Kinders; Yan Shi; Cherrie Donawho; Paul A Ellis; Luis E Rodriguez; Milagros Colon-Lopez; Mary Saltarelli; David LeBlond; C Thomas Lin; David Frost; Yan Luo; Vincent L Giranda
An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors.
Xuesong Liu; Yan Shi; Ran Guan; Cherrie Donawho; Yanping Luo; Joann Palma; Gui-Dong Zhu; Eric F Johnson; Luis E Rodriguez; Nayereh Ghoreishi-Haack; Ken Jarvis; Vincent P Hradil; Milagros Colon-Lopez; Bryan F Cox; Vered Klinghofer; Thomas Penning; Saul H Rosenberg; David Frost; Vincent L Giranda; Yan Luo
Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.
Scott Ackler; Yu Xiao; Michael J Mitten; Kelly Foster; Anatol Oleksijew; Marion Refici; Sally Schlessinger; Baole Wang; Sanjay R Chemburkar; Joy Bauch; Christin Tse; David Frost; Stephen W Fesik; Saul H Rosenberg; Steven W Elmore; Alexander R Shoemaker
ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo.

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2008: Xuesong Liu; Joann Palma; Robert Kinders; Yan Shi; Cherrie Donawho; Paul A Ellis; Luis E Rodriguez; Milagros Colon-Lopez; Mary Saltarelli; David LeBlond; C Thomas Lin; David Frost; Yan Luo; Vincent L Giranda
An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors.
Analytical biochemistry 2008;381(2):240-7.
2008: Xuesong Liu; Yan Shi; Ran Guan; Cherrie Donawho; Yanping Luo; Joann Palma; Gui-Dong Zhu; Eric F Johnson; Luis E Rodriguez; Nayereh Ghoreishi-Haack; Ken Jarvis; Vincent P Hradil; Milagros Colon-Lopez; Bryan F Cox; Vered Klinghofer; Thomas Penning; Saul H Rosenberg; David Frost; Vincent L Giranda; Yan Luo
Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.
Molecular cancer research : MCR 2008;6(10):1621-9.
2008: Scott Ackler; Yu Xiao; Michael J Mitten; Kelly Foster; Anatol Oleksijew; Marion Refici; Sally Schlessinger; Baole Wang; Sanjay R Chemburkar; Joy Bauch; Christin Tse; David Frost; Stephen W Fesik; Saul H Rosenberg; Steven W Elmore; Alexander R Shoemaker
ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo.
Molecular cancer therapeutics 2008;7(10):3265-74.
2008: Gui-Dong Zhu; Viraj B Gandhi; Jianchun Gong; Sheela Thomas; Yan Luo; Xuesong Liu; Yan Shi; Vered Klinghofer; Eric F Johnson; David Frost; Cherrie Donawho; Ken Jarvis; Jennifer J Bouska; Kennan Marsh; Saul H Rosenberg; Vincent L Giranda; Thomas D Penning
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent.
Bioorganic & medicinal chemistry letters 2008;18(14):3955-8.
2008: Alex R Shoemaker; Michael J Mitten; Jessica Adickes; Scott Ackler; Marion Refici; Debra Ferguson; Anatol Oleksijew; Jacqueline M O'Connor; Baole Wang; David Frost; Joy Bauch; Kennan Marsh; Steven K Tahir; Xiufen Yang; Christin Tse; Stephen W Fesik; Saul H Rosenberg; Steven W Elmore
Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3268-77.
2007: Timothy Jorgensen; Hui Tian; Ingrid B J K Joseph; Krishna Menon; David Frost
Chemosensitization and radiosensitization of human lung and colon cancers by antimitotic agent, ABT-751, in athymic murine xenograft models of subcutaneous tumor growth.
Cancer chemotherapy and pharmacology 2007;59(6):725-32.
2006: Alexander R Shoemaker; Anatol Oleksijew; Joy Bauch; Barbara A Belli; Tony Borre; Milan Bruncko; Thomas Deckwirth; David Frost; Ken Jarvis; Mary K Joseph; Kennan Marsh; William McClellan; Hugh Nellans; Shichung Ng; Paul M Nimmer; Jacqueline M O'Connor; Tilman Oltersdorf; Weiguo Qing; Wang Shen; Jason Stavropoulos; Stephen K Tahir; Baole Wang; Robert Warner; Haichao Zhang; Stephen W Fesik; Saul H Rosenberg; Steven W Elmore
A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo.
Cancer research 2006;66(17):8731-9.
2006: Shao H Yang; Margarita Meta; Xin Qiao; David Frost; Joy Bauch; Catherine Coffinier; Sharmila Majumdar; Martin O Bergo; Stephen G Young; Loren G Fong
A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.
The Journal of clinical investigation 2006;116(8):2115-21.
2006: Loren G Fong; David Frost; Margarita Meta; Xin Qiao; Shao H Yang; Catherine Coffinier; Stephen G Young
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.
Science (New York, N.Y.) 2006;311(5767):1621-3.
2005: Wen-Zhen Gu; Ingrid B J K Joseph; Yi-Chun Wang; David Frost; Gerard M Sullivan; Le Wang; Nan-Horng Lin; Jerry Cohen; Vincent S Stoll; Clarissa Jakob; Steven W Muchmore; John Harlan; Thomas F Holzman; Karl A Walten; Uri S Ladror; Mark G Anderson; Paul Kroeger; Luis E Rodriguez; Ken Jarvis; Debra Ferguson; Kennan Marsh; Shichung Ng; Saul H Rosenberg; Hing L Sham; Haiying Zhang
A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies.
Anti-cancer drugs 2005;16(10):1059-69.
2005: Qun Li; Tongmei Li; Keith W Woods; Wen-Zhen Gu; Jerry Cohen; Vincent S Stoll; Tomas Galicia; Charles W Hutchins; David Frost; Saul H Rosenberg; Hing L Sham
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.
Bioorganic & medicinal chemistry letters 2005;15(11):2918-22.
2005: Debra Ferguson; Luis E Rodriguez; Joann P Palma; Marion Refici; Ken Jarvis; Jacqueline O'Connor; Gerard M Sullivan; David Frost; Kennan Marsh; Joy Bauch; Haiying Zhang; Nan-Horng Lin; Saul Rosenberg; Hing L Sham; Ingrid B J K Joseph
Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):3045-54.
2005: Qun Li; Keith W Woods; Weibo Wang; Nan-Horng Lin; Akiyo Claiborne; Wen-Zhen Gu; Jerry Cohen; Vincent S Stoll; Charles W Hutchins; David Frost; Saul H Rosenberg; Hing L Sham
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(8):2033-9.
2004: Qun Li; Gary T Wang; Tongmei Li; Stephen L Gwaltney; Keith W Woods; Akiyo Claiborne; Xilu Wang; Wendy Gu; Jerry Cohen; Vincent S Stoll; Charles W Hutchins; David Frost; Saul H Rosenberg; Hing L Sham
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5371-6.
2004: Qun Li; Akiyo Claiborne; Tongmei Li; Lisa Hasvold; Vincent S Stoll; Steven W Muchmore; Clarissa Jakob; Wendy Gu; Jerry Cohen; Charles W Hutchins; David Frost; Saul H Rosenberg; Hing L Sham
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5367-70.
2003: Jieyi Wang; George S Sheppard; Pingping Lou; Megumi Kawai; Nwe Y BaMaung; Scott A Erickson; Lora Tucker-Garcia; Chang Park; Jennifer J Bouska; Yi-Chun Wang; David Frost; Paul Tapang; Daniel H Albert; Sherry J Morgan; Michael J Morowitz; Susanne Shusterman; John M Maris; Rick Lesniewski; Jack Henkin
Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2.
Cancer research 2003;63(22):7861-9.
2003: Nan-Horng Lin; Le Wang; Jerry Cohen; Wen-Zhen Gu; David Frost; Haiying Zhang; Saul Rosenberg; Hing L Sham
Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.
Bioorganic & medicinal chemistry letters 2003;13(21):3821-5.
2003: Michael L Curtin; Alan S Florjancic; Jerome Cohen; Wen-Zhen Gu; David Frost; Steven W Muchmore; Hing L Sham
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
Bioorganic & medicinal chemistry letters 2003;13(7):1367-71.
2003: Stephen L Gwaltney; Stephen J O'Connor; Lissa T J Nelson; Gerard M Sullivan; Hovis Imade; Weibo Wang; Lisa Hasvold; Qun Li; Jerome Cohen; Wen-Zhen Gu; Stephen K Tahir; Joy Bauch; Kennan Marsh; Shi-Chung Ng; David Frost; Haiying Zhang; Steven W Muchmore; Clarissa Jakob; Vincent S Stoll; Charles W Hutchins; Saul H Rosenberg; Hing L Sham
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Bioorganic & medicinal chemistry letters 2003;13(7):1363-6.
2003: Stephen L Gwaltney; Stephen J O'Connor; Lissa T J Nelson; Gerard M Sullivan; Hovis Imade; Weibo Wang; Lisa Hasvold; Qun Li; Jerome Cohen; Wen-Zhen Gu; Stephen K Tahir; Joy Bauch; Kennan Marsh; Shi-Chung Ng; David Frost; Haiying Zhang; Steven W Muchmore; Clarissa Jakob; Vincent S Stoll; Charles W Hutchins; Saul H Rosenberg; Hing L Sham
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Bioorganic & medicinal chemistry letters 2003;13(7):1359-62.
2003: Nan-Horng Lin; Le Wang; Jerry Cohen; Wen-Zhen Gu; David Frost; Haiying Zhang; Saul Rosenberg; Hing L Sham
Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.
Bioorganic & medicinal chemistry letters 2003;13(7):1293-6.
2003: Stephen K Tahir; Michael A Nukkala; Nicolette A Zielinski Mozny; Robert B Credo; Robert B Warner; Qun Li; Keith W Woods; Akiyo Claiborne; Stephen L Gwaltney; David Frost; Hing L Sham; Saul H Rosenberg; Shi-Chung Ng
Biological activity of A-289099: an orally active tubulin-binding indolyloxazoline derivative.
Molecular cancer therapeutics 2003;2(3):227-33.
2003: Jonathan A Meulbroek; Angela M Nilius; Qun Li; Weibo Wang; Lisa Hasvold; Beth Steiner; Daniel A Dickman; Hong Ding; David Frost; Robert C Goldman; Paul Lartey; Jacob J Plattner; Youssef L Bennani
In vivo characterization of A-192411: a novel fungicidal lipopeptide (II).
Bioorganic & medicinal chemistry letters 2003;13(3):495-7.
2003: Weibo Wang; Qun Li; Lisa Hasvold; Beth Steiner; Daniel A Dickman; Hong Ding; Akyio Clairborne; Hui-Ju Chen; David Frost; Robert C Goldman; Kennan Marsh; Yu-Hua Hui; Brian Cox; Angela M Nilius; Darlene Balli; Paul Lartey; Jacob J Plattner; Youssef L Bennani
Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: a novel fungicidal lipopeptide-(I).
Bioorganic & medicinal chemistry letters 2003;13(3):489-93.
2002: Le Wang; Keith W Woods; Qun Li; Kenneth J Barr; Richard W McCroskey; Steven M Hannick; Laura Gherke; Robert B Credo; Yu-Hua Hui; Kennan Marsh; Robert Warner; Jang Y Lee; Nicolette Zielinski-Mozng; David Frost; Saul H Rosenberg; Hing L Sham
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Journal of medicinal chemistry 2002;45(8):1697-711.
2002: Qun Li; Keith W Woods; Akiyo Claiborne; Stephen L Gwaltney; Kenneth J Barr; Gang Liu; Laura Gehrke; Robert B Credo; Yu-Hua Hui; Jang Lee; Robert B Warner; Peter Kovar; Michael A Nukkala; Nicolette A Zielinski; Stephen K Tahir; Michael Fitzgerald; Ki H Kim; Kennan Marsh; David Frost; Shi-Chung Ng; Saul Rosenberg; Hing L Sham
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.
Bioorganic & medicinal chemistry letters 2002;12(3):465-9.
2001: Bruce G Szczepankiewicz; Gang Liu; Hwan-Soo Jae; Andrew Tasker; IW Gunawardana; Thomas W von Geldern; Stephen L Gwaltney; J Ruth Wu-Wong; Laura Gehrke; William J Chiou; Robert B Credo; JD Alder; Michael A Nukkala; Nicolette A Zielinski; Ken Jarvis; Karl W Mollison; David Frost; Joy Bauch; Yu-Hua Hui; Akiyo Claiborne; Qun Li; Saul H Rosenberg
New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.
Journal of medicinal chemistry 2001;44(25):4416-30.
2001: Stephen K Tahir; Edward K Han; B Credo; Hwan-Soo Jae; Jennifer A Pietenpol; CD Scatena; J Ruth Wu-Wong; David Frost; Hing L Sham; Saul H Rosenberg; Shi-Chung Ng
A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.
Cancer research 2001;61(14):5480-5.
2001: Stephen L Gwaltney; Hovis Imade; Qun Li; Laura Gehrke; Robert B Credo; Robert B Warner; Jang Y Lee; Peter Kovar; David Frost; Shi-Chung Ng; Hing L Sham
Novel sulfonate derivatives: potent antimitotic agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1671-3.
2001: Stephen L Gwaltney; Hovis Imade; Kenneth J Barr; Qun Li; Laura Gehrke; Robert B Credo; Robert B Warner; Jang Y Lee; Peter Kovar; Jieyi Wang; Michael A Nukkala; Nicolette A Zielinski; David Frost; Shi-Chung Ng; Hing L Sham
Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
Bioorganic & medicinal chemistry letters 2001;11(7):871-4.
1998: John O Capobianco; Dorothy Zakula; David Frost; Robert C Goldman; Leping Li; Larry Klein; Paul Lartey
Cellular accumulation, localization, and activity of a synthetic cyclopeptamine in fungi.
Antimicrobial agents and chemotherapy 1998;42(2):389-93.
1997: G Gunawardana; R R Rasmussen; M Scherr; David Frost; K D Brandt; W Choi; M Jackson; J P Karwowski; G Sunga; L H Malmberg; P West; R H Chen; S Kadam; J J Clement; J B McAlpine
Corynecandin: a novel antifungal glycolipid from Coryneum modonium.
The Journal of antibiotics 1997;50(10):884-6.
1997: David Frost; M Knapp; K Brandt; A Shadron; Robert C Goldman
Characterization of a lipopeptide-resistant strain of Candida albicans.
Canadian journal of microbiology 1997;43(2):122-8.
1997: Aparna V Sarthy; Thomas McGonigal; Michael Coen; David Frost; Jonathan A Meulbroek; Robert C Goldman
Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-beta-glucosyltransferase.
Microbiology (Reading, England) 1997;143 ( Pt 2)():367-76.
1997: David Frost; K Brandt; C Estill; R Goldman
Partial purification of (1,3)-beta-glucan synthase from Candida albicans.
FEMS microbiology letters 1997;146(2):255-61.
1996: R H Chen; S Tennant; David Frost; M J O'Beirne; J P Karwowski; P E Humphrey; L H Malmberg; W Choi; K D Brandt; P West; S K Kadam; J J Clement; J B McAlpine
Discovery of saricandin, a novel papulacandin, from a Fusarium species.
The Journal of antibiotics 1996;49(6):596-8.
1995: Robert C Goldman; David Frost; John O Capobianco; S Kadam; R R Rasmussen; Cele Abad-Zapatero
Antifungal drug targets: Candida secreted aspartyl protease and fungal wall beta-glucan synthesis.
Infectious agents and disease 1995;4(4):228-47.
1995: David Frost; K Brandt; T Kaufmann; R Goldman
Interaction of sulfhydryl reactive reagents with components involved in (1,3)-beta-glucan synthesis from Candida albicans.
Canadian journal of microbiology 1995;41(8):692-8.
1995: M Jackson; David Frost; J P Karwowski; P E Humphrey; S K Dahod; W S Choi; K Brandt; L H Malmberg; R R Rasmussen; M H Scherr
Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. I. Identity of the producing organism, fermentation and biological activity.
The Journal of antibiotics 1995;48(7):608-13.
1995: David Frost; K D Brandt; D Cugier; R Goldman
A whole-cell Candida albicans assay for the detection of inhibitors towards fungal cell wall synthesis and assembly.
The Journal of antibiotics 1995;48(4):306-10.
1994: David Frost; K Brandt; John O Capobianco; R Goldman
Characterization of (1,3)-beta-glucan synthase in Candida albicans: microsomal assay from the yeast or mycelial morphological forms and a permeabilized whole-cell assay.
Microbiology (Reading, England) 1994;140 ( Pt 9)():2239-46.