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Jennifer Frost

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Chemicals & Drugs

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Publications

TOP 3
Derek W Nelson; Madhavi Pai; Keith Ryther; Karin R Tietje; Betty Yao; Chang Zhu; William A Carroll; Prasant Chandran; Michael J Dart; Anthony V Daza; Odile F El-Kouhen; Yihong Fan; Alan S Florjancic; Jennifer M Frost; Tiffany R Garrison; George Grayson; Bradley A Hooker; Gin C Hsieh; Michael D Meyer
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management.
Michael R Schrimpf; Kevin B Sippy; Carol S Surowy; David J Anderson; Clark A Briggs; William H Bunnelle; Jennifer M Frost; Murali Gopalakrishnan; Jianguo Ji; Tao Li; Michael D Meyer
SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.
Jennifer M Frost; Michael J Dart; Karin R Tietje; Tiffany garrison; George Grayson; Anthony V Daza; Odile F El-Kouhen; Betty B Yao; Gin C Hsieh; Madhavi Pai; Chang Z Zhu; Prasant Chandran; Michael D Meyer
Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.

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All Publications

2012: Derek W Nelson; Madhavi Pai; Keith Ryther; Karin R Tietje; Betty Yao; Chang Zhu; William A Carroll; Prasant Chandran; Michael J Dart; Anthony V Daza; Odile F El-Kouhen; Yihong Fan; Alan S Florjancic; Jennifer M Frost; Tiffany R Garrison; George Grayson; Bradley A Hooker; Gin C Hsieh; Michael D Meyer
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management.
Bioorganic & medicinal chemistry letters 2012;22(7):2604-8.
2012: Michael R Schrimpf; Kevin B Sippy; Carol S Surowy; David J Anderson; Clark A Briggs; William H Bunnelle; Jennifer M Frost; Murali Gopalakrishnan; Jianguo Ji; Tao Li; Michael D Meyer
SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.
Bioorganic & medicinal chemistry letters 2012;22(4):1633-8.
2010: Jennifer M Frost; Michael J Dart; Karin R Tietje; Tiffany garrison; George Grayson; Anthony V Daza; Odile F El-Kouhen; Betty B Yao; Gin C Hsieh; Madhavi Pai; Chang Z Zhu; Prasant Chandran; Michael D Meyer
Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.
Journal of medicinal chemistry 2010;53(1):295-315.
2009: Jens Halvard Gronlien; Karin R Tietje; Jennifer M Frost; Dan Peters; Jianguo Ji; Tao Li; Marc J C Scanio; Lei Shi; David J Anderson; Tino Dyhring; Jens H Grønlien; Hilde Ween; Kirsten Thorin-Hagene; Michael D Meyer
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.
Journal of medicinal chemistry 2009;52(14):4126-41.
2008: Jennifer M Frost; Michael J Dart; Karin R Tietje; Tiffany garrison; George Grayson; Anthony V Daza; Odile F El-Kouhen; Loan N Miller; Lanlan Li; Betty B Yao; Gin C Hsieh; Madhavi Pai; Chang Z Zhu; Prasant Chandran; Michael D Meyer
Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.
Journal of medicinal chemistry 2008;51(6):1904-12.
2008: Betty B Yao; Gin C Hsieh; Jennifer M Frost; Y Fan; Tiffany garrison; Anthony V Daza; George Grayson; Chang Z Zhu; M Pai; Prasant Chandran; A K Salyers; E J Wensink; Prisca Honore; James P Sullivan; Michael J Dart; Michael D Meyer
In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.
British journal of pharmacology 2008;153(2):390-401.
2008: Chih-Liang Chin; A E Tovcimak; Vincent P Hradil; Terese R Seifert; Peter R Hollingsworth; Prasant Chandran; Chang Z Zhu; Donna M Gauvin; M Pai; Jill M Wetter; Gin C Hsieh; Prisca Honore; Jennifer M Frost; Michael J Dart; Michael D Meyer; Betty B Yao; Bryan Cox; Gerard B Fox
Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI.
British journal of pharmacology 2008;153(2):367-79.
2007: Robert S Bitner; William H Bunnelle; David J Anderson; Jens Halvard Gronlien; Jerry J Buccafusco; Peter Curzon; Michael W Decker; Jennifer M Frost; Jens Halvard Gronlien; Earl J Gubbins; Jinhe Li; John Malysz; Stella Markosyan; Kennan Marsh; Michael D Meyer; Arthur L Nikkel; Richard J Radek; Holly M Robb; Daniel Timmermann; James P Sullivan; Murali Gopalakrishnan
Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(39):10578-87.
2007: William H Bunnelle; Jerome F Daanen; Keith B Ryther; Michael R Schrimpf; Michael J Dart; Arianna Gelain; Michael D Meyer; Jennifer M Frost; David J Anderson; Michael Buckley; Peter Curzon; YING-JUN CAO; Pamela S Puttfarcken; Xenia Searle; Jianguo Ji; C Brent Putman; Carol S Surowy; Lucio Toma; Daniela Barlocco
Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
Journal of medicinal chemistry 2007;50(15):3627-44.
2006: Jennifer M Frost; William H Bunnelle; Karin R Tietje; David J Anderson; Lynne E Rueter; Peter Curzon; Carol S Surowy; Jianguo Ji; Jerome F Daanen; Kathy L Kohlhaas; Michael J Buckley; Rodger F Henry; Tino Dyhring; Philip K Ahring; Michael D Meyer
Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.
Journal of medicinal chemistry 2006;49(26):7843-53.