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Robert Frost

Research Profile

Anatomy

Muscle, Skeletal

Chemicals & Drugs

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Publications

TOP 3
Robert A Frost; Charles H Lang
Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle.
Robert A Frost; Charles H Lang
mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong?
Abid A Kazi; Anne M Pruznak; Robert A Frost; Charles H Lang
Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis.

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All Publications

2012: Robert A Frost; Charles H Lang
Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle.
Endocrinology and metabolism clinics of North America 2012;41(2):297-322, vi.
2011: Robert A Frost; Charles H Lang
mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong?
Physiology (Bethesda, Md.) 2011;26(2):83-96.
2011: Abid A Kazi; Anne M Pruznak; Robert A Frost; Charles H Lang
Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis.
Shock (Augusta, Ga.) 2011;35(2):117-25.
2011: Robert A Frost; Erika Pereyra; Charles H Lang
Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes.
Endocrinology 2011;152(1):151-63.
2010: Charles H Lang; Robert A Frost; Sarah K Bronson; Christopher J Lynch; Thomas C Vary
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.
American journal of physiology. Endocrinology and metabolism 2010;298(6):E1283-94.
2009: Robert A Frost; Danuta Huber; Anne Pruznak; Charles H Lang
Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes.
Journal of cellular biochemistry 2009;108(5):1192-202.
2009: Robert A Frost; Gerald J Nystrom; Charles H Lang
Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity.
Shock (Augusta, Ga.) 2009;32(4):416-26.
2009: Gerald J Nystrom; Anne Pruznak; Danuta Huber; Robert A Frost; Charles H Lang
Local insulin-like growth factor I prevents sepsis-induced muscle atrophy.
Metabolism: clinical and experimental 2009;58(6):787-97.
2008: Anne M Pruznak; Abid A Kazi; Robert A Frost; Thomas C Vary; Charles H Lang
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle.
The Journal of nutrition 2008;138(10):1887-94.
2008: Charles H Lang; Robert A Frost; Thomas C Vary
Acute alcohol intoxication increases REDD1 in skeletal muscle.
Alcoholism, clinical and experimental research 2008;32(5):796-805.
2008: Robert A Frost; Charles H Lang
Regulation of muscle growth by pathogen-associated molecules.
Journal of animal science 2008;86(14 Suppl):E84-93.
2008: Charles H Lang; Gerald Nystrom; Robert A Frost
Beta-adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor alpha and interleukin-6 in skeletal muscle and is associated with impaired translation initiation.
The Journal of trauma 2008;64(2):477-86.
2007: Charles H Lang; Robert A Frost; Thomas C Vary
Regulation of muscle protein synthesis during sepsis and inflammation.
American journal of physiology. Endocrinology and metabolism 2007;293(2):E453-9.
2007: Robert A Frost; Charles H Lang
Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(1):378-87.
2007: Charles H Lang; Robert A Frost; Thomas C Vary
Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1497-506.
2007: Brian J Krawiec; Gerald J Nystrom; Robert A Frost; Leonard S Jefferson; Charles H Lang
AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1555-67.
2007: Robert A Frost; Gerald J Nystrom; Leonard S Jefferson; Charles H Lang
Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2007;292(2):E501-12.
2007: Charles H Lang; Robert A Frost
Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha.
Metabolism: clinical and experimental 2007;56(1):49-57.
2007: Charles H Lang; Danuta Huber; Robert A Frost
Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(1):R328-36.
2006: Charles H Lang; Robert A Frost
Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle.
Molecular medicine (Cambridge, Mass.) 2006;12(11-12):291-9.
2006: Charles H Lang; Brian J Krawiec; Danuta Huber; Jennifer M McCoy; Robert A Frost
Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(4):R963-72.
2006: Robert A Frost; Gerald J Nystrom; Charles H Lang
Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;290(3):R773-84.
2005: Brian J Krawiec; Robert A Frost; Thomas C Vary; Leonard S Jefferson; Charles H Lang
Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis.
American journal of physiology. Endocrinology and metabolism 2005;289(6):E969-80.
2005: Charles H Lang; Robert A Frost; Andrew D Summer; Thomas C Vary
Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart.
The international journal of biochemistry & cell biology 2005;37(10):2180-95.
2005: Ly Q Hong-Brown; Anne M Pruznak; Robert A Frost; Thomas C Vary; Charles H Lang
Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E382-90.
2005: Robert A Frost; Gerald J Nystrom; Patricia V Burrows; Charles H Lang
Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions.
Alcoholism, clinical and experimental research 2005;29(7):1247-56.
2005: Robert A Frost; Charles H Lang
Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones.
Current opinion in clinical nutrition and metabolic care 2005;8(3):255-63.
2005: Charles H Lang; Robert A Frost
Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle.
Journal of cellular physiology 2005;203(1):144-55.
2005: Charles H Lang; Ly Q Hong-Brown; Robert A Frost
Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance.
Pediatric nephrology (Berlin, Germany) 2005;20(3):306-12.
2005: Charles H Lang; Anne M Pruznak; Robert A Frost
TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle.
Journal of cellular biochemistry 2005;94(2):419-31.
2004: Robert A Frost; Gerald J Nystrom; Charles H Lang
Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways.
American journal of physiology. Cell physiology 2004;287(6):C1605-15.
2004: Charles H Lang; Anne M Pruznak; Nobuko Deshpande; Margaret M Palopoli; Robert A Frost; Thomas C Vary
Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism.
Alcoholism, clinical and experimental research 2004;28(11):1758-67.
2004: Charles H Lang; Nobuko Deshpande; Robert A Frost
Leucine acutely reverses burn-induced alterations in translation initiation in heart.
Shock (Augusta, Ga.) 2004;22(4):326-32.
2004: Charles H Lang; Robert A Frost
Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation.
American journal of physiology. Endocrinology and metabolism 2004;287(4):E721-30.
2004: Charles H Lang; Robert A Frost; Elisabeth Svanberg; Thomas C Vary
IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats.
American journal of physiology. Endocrinology and metabolism 2004;286(6):E916-26.
2004: Robert A Frost; Gerald J Nystrom; Charles H Lang
Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity.
American journal of physiology. Endocrinology and metabolism 2004;286(5):E809-17.
2004: Charles H Lang; Robert A Frost; Thomas C Vary
Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiation.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;286(4):R740-50.
2004: Robert A Frost; Charles H Lang
Alteration of somatotropic function by proinflammatory cytokines.
Journal of animal science 2004;82 E-Suppl():E100-109.
2003: Charles H Lang; Robert A Frost; Nobuko Deshpande; Vinayshree Kumar; Thomas C Vary; Leonard S Jefferson; Scot R Kimball
Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2003;285(6):E1205-15.
2003: Robert A Frost; Gerald J Nystrom; Charles H Lang
Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;285(5):R1153-64.
2003: Charles H Lang; Thomas C Vary; Robert A Frost
Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis.
Endocrinology 2003;144(9):3922-33.
2003: Ly Q Hong-Brown; C Randell Brown; Robert N Cooney; Robert A Frost; Charles H Lang
Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation.
American journal of physiology. Endocrinology and metabolism 2003;285(1):E63-72.
2003: Charles H Lang; Christine Silvis; Nobuko Deshpande; Gerald J Nystrom; Robert A Frost
Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle.
Shock (Augusta, Ga.) 2003;19(6):538-46.
2003: Robert A Frost; Gerald J Nystrom; Charles H Lang
Tumor necrosis factor-alpha decreases insulin-like growth factor-I messenger ribonucleic acid expression in C2C12 myoblasts via a Jun N-terminal kinase pathway.
Endocrinology 2003;144(5):1770-9.
2003: Robert A Frost; Charles H Lang
Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells.
Minerva endocrinologica 2003;28(1):53-73.
2002: Vinayshree Kumar; Robert A Frost; Charles H Lang
Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2002;283(5):E917-28.
2002: Vinayshree Kumar; Christine Silvis; Gerald J Nystrom; Nobuko Deshpande; Thomas C Vary; Robert A Frost; Charles H Lang
Alcohol-induced increases in insulin-like growth factor binding protein-1 are partially mediated by TNF.
Alcoholism, clinical and experimental research 2002;26(10):1574-83.
2002: Robert A Frost; Gerald J Nystrom; Charles H Lang
Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(3):R698-709.
2002: Charles H Lang; Robert A Frost
Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection.
Current opinion in clinical nutrition and metabolic care 2002;5(3):271-9.
2002: Robert A Frost; Gerald J Nystrom; Charles H Lang
Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblasts.
Endocrinology 2002;143(2):492-503.
2002: Charles H Lang; Robert A Frost; Angus Nairn; David A MacLean; Thomas C Vary
TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation.
American journal of physiology. Endocrinology and metabolism 2002;282(2):E336-47.
2002: Charles H Lang; Gerald J Nystrom; Robert A Frost
Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(1):R207-15.
2001: Ly Q Hong-Brown; Robert A Frost; Charles H Lang
Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells.
Alcoholism, clinical and experimental research 2001;25(9):1373-82.
2001: Charles H Lang; Gerald J Nystrom; Robert A Frost
Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFalpha.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2001;11(4):250-60.
2001: Charles H Lang; Christine Silvis; Gerald J Nystrom; Robert A Frost
Regulation of myostatin by glucocorticoids after thermal injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(10):1807-9.
2001: Charles H Lang; Scot R Kimball; Robert A Frost; Thomas C Vary
Alcohol myopathy: impairment of protein synthesis and translation initiation.
The international journal of biochemistry & cell biology 2001;33(5):457-73.
2000: Elisabeth Svanberg; Robert A Frost; C H Lang; Jörgen Isgaard; L S Jefferson; S R Kimball; Thomas C Vary
IGF-I/IGFBP-3 binary complex modulates sepsis-induced inhibition of protein synthesis in skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1145-58.
2000: Charles H Lang; Robert A Frost; Vinayshree Kumar; Thomas C Vary
Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1029-38.
2000: Robert A Frost; Gerald J Nystrom; Charles H Lang
Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathway.
Endocrinology 2000;141(9):3156-64.
2000: Charles H Lang; Robert A Frost; Leonard S Jefferson; Scot R Kimball; Thomas C Vary
Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E1133-43.
2000: Charles H Lang; X Liu; Gerald J Nystrom; Robert A Frost
Acute response of IGF-I and IGF binding proteins induced by thermal injury.
American journal of physiology. Endocrinology and metabolism 2000;278(6):E1087-96.
2000: Charles H Lang; X Liu; Gerald J Nystrom; D Wu; Robert N Cooney; Robert A Frost
Acute effects of growth hormone in alcohol-fed rats.
Alcohol and alcoholism (Oxford, Oxfordshire) 2000;35(2):148-58.
2000: Charles H Lang; Robert A Frost; Vinayshree Kumar; D Wu; Thomas C Vary
Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver.
Alcoholism, clinical and experimental research 2000;24(3):322-31.
1999: Charles H Lang; D Wu; Robert A Frost; Leonard S Jefferson; Thomas C Vary; Scot R Kimball
Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E.
The American journal of physiology 1999;277(5 Pt 1):E805-14.
1999: Robert A Frost; Charles H Lang
Differential effects of insulin-like growth factor I (IGF-I) and IGF-binding protein-1 on protein metabolism in human skeletal muscle cells.
Endocrinology 1999;140(9):3962-70.
1999: Charles H Lang; D Wu; Robert A Frost; Leonard S Jefferson; Scot R Kimball; Thomas C Vary
Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E.
The American journal of physiology 1999;277(2 Pt 1):E268-76.
1999: Charles H Lang; Gerald J Nystrom; Robert A Frost
Regulation of IGF binding protein-1 in hep G2 cells by cytokines and reactive oxygen species.
The American journal of physiology 1999;276(3 Pt 1):G719-27.
1998: Charles H Lang; Robert A Frost; Joseph Ejiofor; D Brooks Lacy; Owen P McGuinness
Hepatic production and intestinal uptake of IGF-I: response to infection.
The American journal of physiology 1998;275(6 Pt 1):G1291-8.
1998: Robert A Frost; Charles H Lang
Growth factors in critical illness: regulation and therapeutic aspects.
Current opinion in clinical nutrition and metabolic care 1998;1(2):195-204.