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Izabel Frugulhetti

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Bruno Leal; Ilídio F Afonso; Carlos Rangel Rodrigues; Paula A Abreu; Rafael Garrett; Luiz Carlos S Pinheiro; Alexandre R Azevedo; Julio C Borges; Percilene F Vegi; Cláudio C C Santos; Francisco C A da Silveira; Lúcio Mendes Cabral; Izabel C P P Frugulhetti; Alice Maria Rolim Bernardino; Dilvani O Santos; Helena C Castro
Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.
Thiago Moreno L Souza; Claudio Cesar Cirne-Santos; Diego Q Rodrigues; Celina M Abreu; Amilcar Tanuri; Vitor F Ferreira; Isakelly Pereira Marques; Maria Cecília B V de Souza; Carlos Frederico Fontes; Izabel C P P Frugulhetti; Dumith Chequer Bou-Habib
The compound 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid inhibits HIV-1 replication by targeting the enzyme reverse transcriptase.
Alice Maria Rolim Bernardino; Helena C Castro; Izabel C P P Frugulhetti; Natália Izabel Loureiro; Alexandre R Azevedo; Luiz C S Pinheiro; Thiago M L Souza; Viveca Giongo; Fabiana Passamani; Uiaran O Magalhães; Magaly Albuquerque; Lúcio Mendes Cabral; Carlos Rangel Rodrigues
SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series.

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All Publications

2008: Bruno Leal; Ilídio F Afonso; Carlos Rangel Rodrigues; Paula A Abreu; Rafael Garrett; Luiz Carlos S Pinheiro; Alexandre R Azevedo; Julio C Borges; Percilene F Vegi; Cláudio C C Santos; Francisco C A da Silveira; Lúcio Mendes Cabral; Izabel C P P Frugulhetti; Alice Maria Rolim Bernardino; Dilvani O Santos; Helena C Castro
Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.
Bioorganic & medicinal chemistry 2008;16(17):8196-204.
2008: Thiago Moreno L Souza; Claudio Cesar Cirne-Santos; Diego Q Rodrigues; Celina M Abreu; Amilcar Tanuri; Vitor F Ferreira; Isakelly Pereira Marques; Maria Cecília B V de Souza; Carlos Frederico Fontes; Izabel C P P Frugulhetti; Dumith Chequer Bou-Habib
The compound 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid inhibits HIV-1 replication by targeting the enzyme reverse transcriptase.
Current HIV research 2008;6(3):209-17.
2008: Alice Maria Rolim Bernardino; Helena C Castro; Izabel C P P Frugulhetti; Natália Izabel Loureiro; Alexandre R Azevedo; Luiz C S Pinheiro; Thiago M L Souza; Viveca Giongo; Fabiana Passamani; Uiaran O Magalhães; Magaly Albuquerque; Lúcio Mendes Cabral; Carlos Rangel Rodrigues
SAR of a series of anti-HSV-1 acridone derivatives, and a rational acridone-based design of a new anti-HSV-1 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridine series.
Bioorganic & medicinal chemistry 2008;16(1):313-21.
2008: Thiago Moreno L Souza; Maria Cecília B V de Souza; Vitor F Ferreira; Carla Veronica B Santos Canuto; Isakelly Pereira Marques; Carlos Frederico Fontes; Izabel C P P Frugulhetti
Inhibition of HSV-1 replication and HSV DNA polymerase by the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid and its aglycone.
Antiviral research 2008;77(1):20-7.
2008: Claudio Cesar Cirne-Santos; Thiago Moreno L Souza; Valéria Laneuville Teixeira; Carlos Frederico Fontes; Moacyr A Rebello; Luiz Roberto R Castello-Branco; Celina M Abreu; Amilcar Tanuri; Izabel C P P Frugulhetti; Dumith Chequer Bou-Habib
The dolabellane diterpene Dolabelladienetriol is a typical noncompetitive inhibitor of HIV-1 reverse transcriptase enzyme.
Antiviral research 2008;77(1):64-71.
2007: Thiago Moreno L Souza; Juliana Lourenço Abrantes; Rosângela de A Epifanio; Carlos Frederico Fontes; Izabel C P P Frugulhetti
The alkaloid 4-methylaaptamine isolated from the sponge Aaptos aaptos impairs Herpes simplex virus type 1 penetration and immediate-early protein synthesis.
Planta medica 2007;73(3):200-5.
2007: T M L Souza; Maria Cecília B V de Souza; Vitor F Ferreira; C V B Santos Canuto; I Pereira Marques; Carlos Frederico Fontes; Izabel C P P Frugulhetti
The chloroxoquinolinic derivative 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid inhibits HSV-1 adsorption by impairing its adsorption on HVEM.
Archives of virology 2007;152(7):1417-24.
2006: Alice Maria Rolim Bernardino; Luiz Carlos da Silva Pinheiro; Carlos Rangel Rodrigues; Natália Izabel Loureiro; Helena C Castro; Adriana Lanfredi-Rangel; Juliano Sabatini-Lopes; Júlio César Borges; Jane Maria Carvalho; Gilberto Alves Romeiro; Vitor F Ferreira; Izabel C P P Frugulhetti; Marcos André Vannier-Santos
Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives.
Bioorganic & medicinal chemistry 2006;14(16):5765-70.
2006: Claudio Cesar Cirne-Santos; Valéria Laneuville Teixeira; Luiz Roberto Castello-Branco; Izabel C P P Frugulhetti; Dumith Chequer Bou-Habib
Inhibition of HIV-1 replication in human primary cells by a dolabellane diterpene isolated from the marine algae Dictyota pfaffii.
Planta medica 2006;72(4):295-9.
2006: Bianca d'A Lucero; Claudia Regina B Gomes; Izabel C P P Frugulhetti; Letícia V Faro; Lise Alvarenga; Maria Cecília B V de Souza; Thiago M L de Souza; Vitor F Ferreira
Synthesis and anti-HSV-1 activity of quinolonic acyclovir analogues.
Bioorganic & medicinal chemistry letters 2006;16(4):1010-3.
2006: Helena C Castro; Natália Izabel Loureiro; Mariana Pujol-Luz; A M T Souza; Magaly Albuquerque; Dilvani O Santos; Lúcio Mendes Cabral; Izabel C P P Frugulhetti; Carlos Rangel Rodrigues
HIV-1 reverse transcriptase: a therapeutical target in the spotlight.
Current medicinal chemistry 2006;13(3):313-24.
2005: Helena de Souza Pereira; Luiz Roberto Leão-Ferreira; Nissin Moussatché; Valéria Laneuville Teixeira; Diana Negrão Cavalcanti; Luciana Jesus da Costa; Ricardo Diaz; Izabel C P P Frugulhetti
Effects of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis on HIV-1 reverse transcriptase.
Planta medica 2005;71(11):1019-24.
2004: Helena S Pereira; Luiz Roberto Leão-Ferreira; Nissin Moussatché; Valéria Laneuville Teixeira; Diana Negrão Cavalcanti; Luciana J Costa; R Diaz; Izabel C P P Frugulhetti
Antiviral activity of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1).
Antiviral research 2004;64(1):69-76.
2004: Jussara Pinheiro Barbosa; Renato Crespo Pereira; Juliana Lourenço Abrantes; Cláudio César Cirne dos Santos; Moacyr A Rebello; Izabel C P P Frugulhetti; Valéria Laneuville Texeira
In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii.
Planta medica 2004;70(9):856-60.
2004: Edinete M Silva; Claudio C Cirne-Santos; Izabel C P P Frugulhetti; Bernardo Galvão-Castro; Elvira M B Saraiva; Martin E Kuehne; Dumith Chequer Bou-Habib
Anti-HIV-1 activity of the Iboga alkaloid congener 18-methoxycoronaridine.
Planta medica 2004;70(9):808-12.
2002: Mara R P de Oliveira; José C Torres; Simon J Garden; Carla Veronica B dos Santos; Thatyana Rocha Alves; Angelo C Pinto; Helena de S Pereira; Luiz Roberto Leão Ferreira; Nissin Moussatché; Izabel C P P Frugulhetti; Vitor F Ferreira; Maria Cecília B V de Souza
Synthesis and antiviral evaluation of isatin ribonucleosides.
Nucleosides, nucleotides & nucleic acids 2002;21(11-12):825-35.