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Judith Frydman

Research Profile

Physiology

Chemicals & Drugs

Genes & Molecular Sequences

t-Complex Genome Region

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Saccharomyces cerevisiae

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Protein Binding

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Publications

TOP 3
Stefanie Duttler; Sebastian Pechmann; Judith Frydman
Principles of cotranslational ubiquitination and quality control at the ribosome.
Sebastian Pechmann; Felix Willmund; Judith Frydman
The ribosome as a hub for protein quality control.
Sebastian Pechmann; Judith Frydman
Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding.

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All Publications

2013: Stefanie Duttler; Sebastian Pechmann; Judith Frydman
Principles of cotranslational ubiquitination and quality control at the ribosome.
Molecular cell 2013;50(3):379-93.
2013: Sebastian Pechmann; Felix Willmund; Judith Frydman
The ribosome as a hub for protein quality control.
Molecular cell 2013;49(3):411-21.
2013: Sebastian Pechmann; Judith Frydman
Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding.
Nature structural & molecular biology 2013;20(2):237-43.
2013: Felix Willmund; Sebastian Pechmann; Junmin Peng; Véronique Albanèse; Taotao Chen; Eric B Dammer; Marta del Alamo; Judith Frydman
The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis.
Cell 2013;152(1-2):196-209.
2013: Ron Geller; Raul Andino; Judith Frydman
Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus.
PloS one 2013;8(2):e56762.
2012: Stefanie Reissmann; Bryan Chen; Lukasz A Joachimiak; Anne S Meyer; Anthony Nguyen; Judith Frydman
A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.
Cell reports 2012;2(4):866-77.
2012: Pedro Beltrao; Alma Burlingame; James S Fraser; Judith Frydman; Lillian R Kenner; Wendell A Lim; Danielle L Swaney; Judit Villén; Véronique Albanèse; Nevan J Krogan
Systematic functional prioritization of protein posttranslational modifications.
Cell 2012;150(2):413-25.
2012: Jose H Pereira; Corie Y Ralston; Nicholai R Douglas; Judith Frydman; Jonathan A King; Kelly M Knee; Ramya Kumar; Tom Lopez; Ryan P McAndrew; Paul D Adams
Mechanism of nucleotide sensing in group II chaperonins.
The EMBO journal 2012;31(3):731-40.
2012: Yao Cong; Matthew T Dougherty; Judith Frydman; Joanita Jakana; Michael Levitt; Steven L Ludtke; Boxue Ma; Anne S Meyer; Stefanie Reissmann; Michael F Schmid; Gunnar F Schröder; Wah Chiu
Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle.
The EMBO journal 2012;31(3):720-30.
2012: Steffen J Sahl; Lucien E Weiss; Whitney C Duim; Judith Frydman; W E Moerner
Cellular inclusion bodies of mutant huntingtin exon 1 obscure small fibrillar aggregate species.
Scientific reports 2012;2():895.
2011: Yan Jiang; Erik J Miller; Nicholas R Conley; Nicholai R Douglas; Judith Frydman; WE Moerner
Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):16962-7.
2011: Whitney C Duim; Judith Frydman; Bryan Chen; WE Moerner
Sub-diffraction imaging of huntingtin protein aggregates by fluorescence blink-microscopy and atomic force microscopy.
Chemphyschem : a European journal of chemical physics and physical chemistry 2011;12(13):2387-90.
2011: Marta del Alamo; Veronique Albanese; Patrick O Brown; Daniel J Hogan; Sebastian Pechmann; Judith Frydman
Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes.
PLoS biology 2011;9(7):e1001100.
2011: Junjie Zhang; Boxue Ma; Frank DiMaio; Nicholai R Douglas; Lukasz A Joachimiak; David Baker; Judith Frydman; Michael Levitt; Wah Chiu
Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure.
Structure (London, England : 1993) 2011;19(5):633-9.
2011: Nicholai R Douglas; Stefanie Reissmann; Junjie Zhang; Bo Chen; Joanita Jakana; Ramya Kumar; Wah Chiu; Judith Frydman
Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber.
Cell 2011;144(2):240-52.
2011: Eric A Franzosa; Judith Frydman; Véronique Albanèse; Yu Xia; Amie J McClellan
Heterozygous yeast deletion collection screens reveal essential targets of Hsp90.
PloS one 2011;6(11):e28211.
2010: So Yeon Kim; Erik Miller; Judith Frydman; WE Moerner
Action of the chaperonin GroEL/ES on a non-native substrate observed with single-molecule FRET.
Journal of molecular biology 2010;401(4):553-63.
2010: Véronique Albanèse; Stefanie Reissmann; Judith Frydman
A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis.
The Journal of cell biology 2010;189(1):69-81.
2009: Nicholas W Kelley; Xuhui Huang; Stephen Tam; Christoph Spiess; Judith Frydman; Vijay S Pande
The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation.
Journal of molecular biology 2009;388(5):919-27.
2008: Alice Yen-Wen Yam; Yu Xia; Hen-Tzu Jill Lin; Alma Burlingame; Mark Gerstein; Judith Frydman
Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies.
Nature structural & molecular biology 2008;15(12):1255-62.
2008: Daniel Kaganovich; Ron R Kopito; Judith Frydman
Misfolded proteins partition between two distinct quality control compartments.
Nature 2008;454(7208):1088-95.
2007: Amie J McClellan; Yu Xia; Adam M Deutschbauer; Ron W Davis; Mark Gerstein; Judith Frydman
Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.
Cell 2007;131(1):121-35.
2007: Stefanie Reissmann; Charles Parnot; Christopher Booth; Wah Chiu; Judith Frydman
Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins.
Nature structural & molecular biology 2007;14(5):432-40.
2007: Ron Geller; Marco Vignuzzi; Raul Andino; Judith Frydman
Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance.
Genes & development 2007;21(2):195-205.
2006: Christoph Spiess; Erik Miller; Amie J McClellan; Judith Frydman
Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins.
Molecular cell 2006;24(1):25-37.
2006: Stephen Tam; Ron Geller; Christoph Spiess; Judith Frydman
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.
Nature cell biology 2006;8(10):1155-62.
2006: Erik Miller; Anne S. Meyer; Judith Frydman
Modeling of possible subunit arrangements in the eukaryotic chaperonin TRiC.
Protein science : a publication of the Protein Society 2006;15(6):1522-6.
2006: Lijun Xu; Manisha Dayal; Yi-Bing Ouyang; Yunjuan Sun; Chin-Fen Yang; Judith Frydman; Rona G Giffard
Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro.
Neurobiology of aging 2006;27(4):562-9.
2006: Véronique Albanèse; Alice Yen-Wen Yam; Joshua Baughman; Charles Parnot; Judith Frydman
Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells.
Cell 2006;124(1):75-88.
2005: So Yeon Kim; Alexander N Semyonov; Robert J Twieg; Arthur L Horwich; Judith Frydman; WE Moerner
Probing the sequence of conformationally induced polarity changes in the molecular chaperonin GroEL with fluorescence spectroscopy.
The journal of physical chemistry. B 2005;109(51):24517-25.
2005: Alice Yen-Wen Yam; Véronique Albanèse; Hen-Tzu Jill Lin; Judith Frydman
Hsp110 cooperates with different cytosolic HSP70 systems in a pathway for de novo folding.
The Journal of biological chemistry 2005;280(50):41252-61.
2005: Amie J McClellan; Stephen Tam; Daniel Kaganovich; Judith Frydman
Protein quality control: chaperones culling corrupt conformations.
Nature cell biology 2005;7(8):736-41.
2005: Stephanie A Etchells; Anne S. Meyer; Alice Yen-Wen Yam; Anne Roobol; Yiwei Miao; Yuanlong Shao; Martin J Carden; William R Skach; Judith Frydman; Arthur E Johnson
The cotranslational contacts between ribosome-bound nascent polypeptides and the subunits of the hetero-oligomeric chaperonin TRiC probed by photocross-linking.
The Journal of biological chemistry 2005;280(30):28118-26.
2005: Amie J McClellan; Melissa D Scott; Judith Frydman
Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways.
Cell 2005;121(5):739-48.
2005: Søren Vang; Thomas J Corydon; Anders D Børglum; Melissa D Scott; Judith Frydman; Jens Mogensen; Niels Gregersen; Peter Bross
Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation.
The FEBS journal 2005;272(8):2037-49.
2004: Christoph Spiess; Anne S. Meyer; Stefanie Reissmann; Judith Frydman
Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.
Trends in cell biology 2004;14(11):598-604.
2003: Douglas E Feldman; Christoph Spiess; Daniel Howard; Judith Frydman
Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding.
Molecular cell 2003;12(5):1213-24.
2003: Anne S. Meyer; Joel R Gillespie; Dirk Walther; Ian S Millet; Sebastian Doniach; Judith Frydman
Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis.
Cell 2003;113(3):369-81.
2003: Mark W. Melville; Amie J McClellan; Anne S. Meyer; Andre Darveau; Judith Frydman
The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex.
Molecular and cellular biology 2003;23(9):3141-51.
2003: Melissa D Scott; Judith Frydman
Aberrant protein folding as the molecular basis of cancer.
Methods in molecular biology (Clifton, N.J.) 2003;232():67-76.
2002: Véronique Albanèse; Judith Frydman
Where chaperones and nascent polypeptides meet.
Nature structural biology 2002;9(10):716-8.
2001: A Y Dunn; Mark W. Melville; Judith Frydman
Review: cellular substrates of the eukaryotic chaperonin TRiC/CCT.
Journal of structural biology 2001;135(2):176-84.
2001: Amie J McClellan; Judith Frydman
Molecular chaperones and the art of recognizing a lost cause.
Nature cell biology 2001;3(2):E51-3.
2001: Judith Frydman
Folding of newly translated proteins in vivo: the role of molecular chaperones.
Annual review of biochemistry 2001;70():603-47.
2000: CD McCallum; H Do; Arthur E Johnson; Judith Frydman
The interaction of the chaperonin tailless complex polypeptide 1 (TCP1) ring complex (TRiC) with ribosome-bound nascent chains examined using photo-cross-linking.
The Journal of cell biology 2000;149(3):591-602.
2000: Douglas E Feldman; Judith Frydman
Protein folding in vivo: the importance of molecular chaperones.
Current opinion in structural biology 2000;10(1):26-33.
2000: V Thulasiraman; RG Ferreyra; Judith Frydman
Folding assays. Assessing the native conformation of proteins.
Methods in molecular biology (Clifton, N.J.) 2000;140():169-77.
2000: V Thulasiraman; RG Ferreyra; Judith Frydman
Monitoring actin folding. Purification protocols for labeled proteins and binding to DNase I-sepharose beads.
Methods in molecular biology (Clifton, N.J.) 2000;140():161-7.
2000: RG Ferreyra; Judith Frydman
Purification of the cytosolic chaperonin TRiC from bovine testis.
Methods in molecular biology (Clifton, N.J.) 2000;140():153-60.
1999: Douglas E Feldman; V Thulasiraman; RG Ferreyra; Judith Frydman
Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.
Molecular cell 1999;4(6):1051-61.
1999: Judith Frydman; H Erdjument-Bromage; Paul Tempst; F U Hartl
Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase.
Nature structural biology 1999;6(7):697-705.
1999: V Thulasiraman; Chin-Fen Yang; Judith Frydman
In vivo newly translated polypeptides are sequestered in a protected folding environment.
The EMBO journal 1999;18(1):85-95.
1998: N Heyrovská; Judith Frydman; J Höhfeld; F Ulrich Hartl
Directionality of polypeptide transfer in the mitochondrial pathway of chaperone-mediated protein folding.
Biological chemistry 1998;379(3):301-9.
1997: Judith Frydman; J Höhfeld
Chaperones get in touch: the Hip-Hop connection.
Trends in biochemical sciences 1997;22(3):87-92.
1996: Judith Frydman; F Ulrich Hartl
Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms.
Science (New York, N.Y.) 1996;272(5267):1497-502.
1994: W Z Li; P Lin; Judith Frydman; Thomas Boal; Thomas S Cardillo; L M Richard; D Toth; M A Lichtman; F Ulrich Hartl; Fred Sherman
Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast.
The Journal of biological chemistry 1994;269(28):18616-22.
1994: Judith Frydman; E Nimmesgern; K Ohtsuka; F Ulrich Hartl
Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones.
Nature 1994;370(6485):111-7.
1992: Judith Frydman; E Nimmesgern; Hediye Erdjument-Bromage; J S Wall; Paul Tempst; F Ulrich Hartl
Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits.
The EMBO journal 1992;11(13):4767-78.