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Reginald Frye

Research Profile

Chemicals & Drugs

Procedures

Physiology

Phenotype

Concepts & Ideas

Anatomy

Microsomes, Liver

Phenomena

Metabolic Clearance Rate

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Publications

TOP 3
Myphuong T Le; Kim K McFann; Christopher J Rivard; Mark S Segal; Jing Cheng; Reginald F Frye; Richard J Johnson; Julie A Johnson
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
Karin Ardjomand-Woelkart; Rudolf Bauer; Hartmut Derendorf; Reginald F Frye; Manfred Kollroser; Christoph Magnes; Frank Sinner; Veronika Butterweck
Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats.
Jaekyu Shin; Reginald F Frye; Taimour Y Langaee; Michael A Pacanowski; Daniel F Pauly; Julie A Johnson
Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.

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All Publications

2012: Myphuong T Le; Kim K McFann; Christopher J Rivard; Mark S Segal; Jing Cheng; Reginald F Frye; Richard J Johnson; Julie A Johnson
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
Metabolism: clinical and experimental 2012;61(5):641-51.
2011: Karin Ardjomand-Woelkart; Rudolf Bauer; Hartmut Derendorf; Reginald F Frye; Manfred Kollroser; Christoph Magnes; Frank Sinner; Veronika Butterweck
Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats.
Planta medica 2011;77(16):1794-9.
2011: Jaekyu Shin; Reginald F Frye; Taimour Y Langaee; Michael A Pacanowski; Daniel F Pauly; Julie A Johnson
Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.
Pharmacotherapy 2011;31(10):942-50.
2011: Mohamed-Eslam F Mohamed; Reginald F Frye
Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(9):1522-8.
2011: Mohamed-Eslam F Mohamed; Reginald F Frye
Effects of herbal supplements on drug glucuronidation. Review of clinical, animal, and in vitro studies.
Planta medica 2011;77(4):311-21.
2010: Mohamed-Eslam F Mohamed; Tiffany Tseng; Reginald F Frye
Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity.
Xenobiotica; the fate of foreign compounds in biological systems 2010;40(10):663-9.
2010: Hrishikesh A Navare; Reginald F Frye; Rhonda M Cooper-DeHoff; Jonathan J Shuster; Karen Hall; Siegfried O F Schmidt; Stephen T Turner; Julie A Johnson
Atenolol exposure and risk for development of adverse metabolic effects: a pilot study.
Pharmacotherapy 2010;30(9):872-8.
2010: Melanie S Joy; Reginald F Frye; Kristi Stubbert; Kim R Brouwer; Ronald J Falk; Evan D Kharasch
Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.
Journal of clinical pharmacology 2010;50(6):714-20.
2010: Melonie L Stanton; Melanie S Joy; Reginald F Frye
Validation and application of a liquid chromatography-tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(3-4):497-501.
2010: Mohamed-Eslam F Mohamed; Reginald F Frye
Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(2):270-5.
2009: Thomas D Nolin; Reginald F Frye; Phuong Le; Hooman Sadr; Judith Naud; Francois A Leblond; Vincent Pichette; Jonathan Himmelfarb
ESRD impairs nonrenal clearance of fexofenadine but not midazolam.
Journal of the American Society of Nephrology : JASN 2009;20(10):2269-76.
2009: Karin Woelkart; Reginald F Frye; Hartmut Derendorf; Rudolf Bauer; Veronika Butterweck
Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats.
Planta medica 2009;75(12):1306-13.
2009: Kyung Mee Kim; George N Henderson; Xiaosen Ouyang; Reginald F Frye; Sautin Yuri; Daniel I Feig; Richard J Johnson
A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(22):2032-8.
2009: Pattaraporn Vanachayangkul; Veronika Butterweck; Reginald F Frye
Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(7):653-6.
2008: Khalid M Alkharfy; Samuel M Poloyac; Mario Congiu; Paul V Desmond; Reginald F Frye
Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats.
Drug metabolism letters 2008;2(4):248-55.
2008: Michael A Pacanowski; Reginald F Frye; Osatohanmen Enogieru; Richard S Schofield; Issam Zineh
Plasma Coenzyme Q10 Predicts Lipid-lowering Response to High-Dose Atorvastatin.
Journal of clinical lipidology 2008;2(4):289-97.
2008: Jaekyu Shin; Daniel F Pauly; Julie A Johnson; Reginald F Frye
Simplified method for determination of clarithromycin in human plasma using protein precipitation in a 96-well format and liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;871(1):130-4.
2008: Mohamed-Eslam F Mohamed; Stephen S Harvey; Reginald F Frye
Determination of mycophenolic acid glucuronide in microsomal incubations using high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;870(2):251-4.
2008: Julie A Johnson; Mariellen J Moore; Jaekyu Shin; Reginald F Frye
A summer research training program to foster PharmD students' interest in research.
American journal of pharmaceutical education 2008;72(2):23.
2008: Prajakta V Dravid; Reginald F Frye
Determination of N-desethylamodiaquine by hydrophilic interaction liquid chromatography with tandem mass spectrometry: application to in vitro drug metabolism studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;863(1):129-34.
2007: Nathalie K Zgheib; Reginald F Frye; Timothy S Tracy; Marjorie Romkes; Robert A Branch
Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.
British journal of clinical pharmacology 2007;63(4):477-87.
2007: Khalid M Alkharfy; Reginald F Frye
Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(2):113-23.
2007: Douglas L Blowey; Bradley A Warady; Susan Abdel-Rahman; Reginald F Frye; Harold J Manley
Vancomycin disposition following intraperitoneal administration in children receiving peritoneal dialysis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2007;27(1):79-85.
2006: Mary Beth O'Connell; Reginald F Frye; Gary R Matzke; John V St Peter; Laurie A Willhite; Margaret R Welch; Paul Kowal; June LaValleur
Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women.
Journal of clinical pharmacology 2006;46(11):1299-307.
2006: Nathalie K Zgheib; Reginald F Frye; Timothy S Tracy; Marjorie Romkes; Robert A Branch
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Clinical pharmacology and therapeutics 2006;80(3):257-63.
2006: Reginald F Frye; Nathalie K Zgheib; Gary R Matzke; Diego Chaves-Gnecco; Mordecai Rabinovitz; Obaid S Shaikh; Robert A Branch
Liver disease selectively modulates cytochrome P450--mediated metabolism.
Clinical pharmacology and therapeutics 2006;80(3):235-45.
2005: Rowland J Elwell; Harold J Manley; Reginald F Frye; George R Bailie
Pharmacokinetics of intraperitoneal cefazolin and ceftazidime coadministered to CAPD patients.
The International journal of artificial organs 2005;28(8):808-16.
2005: Rowland J Elwell; Reginald F Frye; George R Bailie
Pharmacokinetics of intraperitoneal cefepime in automated peritoneal dialysis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2005;25(4):380-6.
2005: Shanshan Liu; Reginald F Frye; Robert A Branch; Raman Venkataramanan; John J Fung; Gilbert J Burckart
Effect of age and postoperative time on cytochrome p450 enzyme activity following liver transplantation.
Journal of clinical pharmacology 2005;45(6):666-73.
2005: Brian G Harbrecht; Reginald F Frye; Mazen S Zenati; Robert A Branch; Andrew B Peitzman
Cytochrome P-450 activity is differentially altered in severely injured patients.
Critical care medicine 2005;33(3):541-6.
2005: Matthew W Hruska; Janet A Amico; Taimour Y Langaee; Robert E Ferrell; Sara M Fitzgerald; Reginald F Frye
The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.
British journal of clinical pharmacology 2005;59(1):70-9.
2004: Zourab Bebia; Shama C Buch; John W Wilson; Reginald F Frye; Marjorie Romkes; Alfred Cecchetti; Diego Chaves-Gnecco; Robert A Branch
Bioequivalence revisited: influence of age and sex on CYP enzymes.
Clinical pharmacology and therapeutics 2004;76(6):618-27.
2004: Matthew W Hruska; Reginald F Frye; Taimour Y Langaee
Pyrosequencing method for genotyping cytochrome P450 CYP2C8 and CYP2C9 enzymes.
Clinical chemistry 2004;50(12):2392-5.
2004: Rowland J Elwell; Lucio R Volino; Reginald F Frye
Stability of cefepime in icodextrin peritoneal dialysis solution.
The Annals of pharmacotherapy 2004;38(12):2041-4.
2004: Reginald F Frye; Sara M Fitzgerald; Theodore F Lagattuta; Matthew W Hruska; Merrill J Egorin
Effect of St John's wort on imatinib mesylate pharmacokinetics.
Clinical pharmacology and therapeutics 2004;76(4):323-9.
2004: Matthew W Hruska; Reginald F Frye
Determination of trimethoprim in low-volume human plasma by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;807(2):301-5.
2004: Samuel M Poloyac; Michael A Tortorici; Danielle I Przychodzin; Robert B Reynolds; Wen Xie; Reginald F Frye; Michael A Zemaitis
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(7):727-33.
2004: Reginald F Frye
Probing the world of cytochrome P450 enzymes.
Molecular interventions 2004;4(3):157-62.
2004: Matthew W Hruska; Reginald F Frye
Simplified method for determination of rosiglitazone in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;803(2):317-20.
2003: Thomas D Nolin; Marc R Gastonguay; Robert R Bies; Gary R Matzke; Reginald F Frye
Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.
Clinical pharmacology and therapeutics 2003;74(6):555-68.
2003: Thomas D Nolin; Reginald F Frye; Gary R Matzke
Hepatic drug metabolism and transport in patients with kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;42(5):906-25.
2003: Christopher A Bolcato; Reginald F Frye; Michael A Zemaitis; Samuel M Poloyac
Determination of 20-hydroxyeicosatetraenoic acid in microsomal incubates using high-performance liquid chromatography-mass spectrometry (HPLC-MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;794(2):363-72.
2003: Joseph A Carcillo; Lesley A Doughty; Danny Kofos; Reginald F Frye; Sandra S Kaplan; Howell Sasser; Gilbert J Burckart
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.
Intensive care medicine 2003;29(6):980-4.
2003: Joseph A Carcillo; Adedayo Adedoyin; Gilbert J Burckart; Reginald F Frye; Raman Venkataramanan; Carmela Knoll; Kenneth Thummel; Lorin K Roskos; John W Wilson; Susan M Sereika; Marjorie Romkes; Zourab Bebia; Robert A Branch
Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation.
Clinical pharmacology and therapeutics 2003;73(5):456-67.
2003: Patricia D Kroboth; Janet A Amico; Roslyn A Stone; Maggie Folan; Reginald F Frye; Frank J Kroboth; Kristin L Bigos; Tanya J Fabian; Ana M Linares; Bruce G Pollock; Charles Hakala
Influence of DHEA administration on 24-hour cortisol concentrations.
Journal of clinical psychopharmacology 2003;23(1):96-9.
2003: Thomas D Nolin; Reginald F Frye
Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;783(1):265-71.
2003: Jackie Dix; Robert J Weber; Reginald F Frye; Thomas D Nolin; Rita Mrvos; Edward P Krenzelok
Stability of atropine sulfate prepared for mass chemical terrorism.
Journal of toxicology. Clinical toxicology 2003;41(6):771-5.
2002: Jang-Ik Lee; Diego Chaves-Gnecco; Janet A Amico; Patricia D Kroboth; John W Wilson; Reginald F Frye
Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping.
Clinical pharmacology and therapeutics 2002;72(6):718-28.
2002: Reginald F Frye; Virginia M Schneider; Carole S Frye; Arthur M Feldman
Plasma levels of TNF-alpha and IL-6 are inversely related to cytochrome P450-dependent drug metabolism in patients with congestive heart failure.
Journal of cardiac failure 2002;8(5):315-9.
2002: LalithKumar K Solai; Bruce G Pollock; Benoit H Mulsant; Reginald F Frye; Mark D Miller; Robert A Sweet; Margaret A Kirshner; Denise Sorisio; Amy E Begley; Charles F Reynolds
Effect of nortriptyline and paroxetine on CYP2D6 activity in depressed elderly patients.
Journal of clinical psychopharmacology 2002;22(5):481-6.
2002: Mohammed Islam; Reginald F Frye; Thomas J Richards; Ibraham Sbeitan; Sandra S Donnelly; Paul Glue; Sanjiv S Agarwala; John M Kirkwood
Differential effect of IFNalpha-2b on the cytochrome P450 enzyme system: a potential basis of IFN toxicity and its modulation by other drugs.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2480-7.
2002: Khalid M Alkharfy; Reginald F Frye
Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;774(1):33-8.
2002: Thomas D Nolin; Ivan V Colaizzi; Paul M Palevsky; Gary R Matzke; Reginald F Frye
Rapid microtiter plate assay for determination of inulin in human plasma and dialysate.
Journal of pharmaceutical and biomedical analysis 2002;28(2):209-15.
2002: Reginald F Frye; Robert A Branch
Effect of chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects.
British journal of clinical pharmacology 2002;53(2):155-62.
2001: J Matthew Hutzler; Reginald F Frye; Kenneth R Korzekwa; Robert A Branch; S M Huang; Timothy S Tracy
Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;14(1):47-52.
2001: Harold J Manley; George R Bailie; Reginald F Frye; M Donald McGoldrick
Intravenous vancomycin pharmacokinetics in automated peritoneal dialysis patients.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2001;21(4):378-85.
2001: Khalid M Alkharfy; Reginald F Frye
High-performance liquid chromatographic assay for acetaminophen glucuronide in human liver microsomes.
Journal of chromatography. B, Biomedical sciences and applications 2001;753(2):303-8.
2001: Kevin M Sowinski; Bruce Mueller; Darren W Grabe; Harold J Manley; Reginald F Frye; George R Bailie; Michael A Marx
Cefazolin dialytic clearance by high-efficiency and high-flux hemodialyzers.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;37(4):766-76.
2001: Thomas C. Dowling; Reginald F Frye; DS Fraley; Gary R Matzke
Characterization of tubular functional capacity in humans using para-aminohippurate and famotidine.
Kidney international 2001;59(1):295-303.
2000: J Matthew Hutzler; Reginald F Frye; Timothy S Tracy
Sensitive and specific high-performance liquid chromatographic assay for 4'-hydroxyflurbiprofen and flurbiprofen in human urine and plasma.
Journal of chromatography. B, Biomedical sciences and applications 2000;749(1):119-25.
2000: Khalid M Alkharfy; John A Kellum; Reginald F Frye; Gary R Matzke
Effect of ceftazidime on systemic cytokine concentrations in rats.
Antimicrobial agents and chemotherapy 2000;44(11):3217-9.
2000: Robert A Branch; Adedayo Adedoyin; Reginald F Frye; John W Wilson; Marjorie Romkes
In vivo modulation of CYP enzymes by quinidine and rifampin.
Clinical pharmacology and therapeutics 2000;68(4):401-11.
2000: Reginald F Frye; Patricia D Kroboth; Frank J Kroboth; Roslyn A Stone; Maggie Folan; Firoozeh S Salek; Bruce G Pollock; Ana M Linares; C Hakala
Sex differences in the pharmacokinetics of dehydroepiandrosterone (DHEA) after single- and multiple-dose administration in healthy older adults.
Journal of clinical pharmacology 2000;40(6):596-605.
2000: Gary R Matzke; Reginald F Frye; Melanie S Joy; Paul M Palevsky
Determinants of ceftriaxone clearance by continuous venovenous hemofiltration and hemodialysis.
Pharmacotherapy 2000;20(6):635-43.
2000: Gary R Matzke; Reginald F Frye; Melanie S Joy; Paul M Palevsky
Determinants of ceftazidime clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis.
Antimicrobial agents and chemotherapy 2000;44(6):1639-44.
2000: Gary R Matzke; Reginald F Frye; John Early; R J Straka; Stanley W Carson
Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity.
Pharmacotherapy 2000;20(2):182-90.
1999: Reginald F Frye; Brinda Tammara; TD Cowart; Steven L Bramer
Effect of disulfiram-mediated CYP2E1 inhibition on the disposition of vesnarinone.
Journal of clinical pharmacology 1999;39(11):1177-83.
1999: Thomas C. Dowling; Reginald F Frye
Determination of famotidine in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1999;732(1):239-43.
1999: Thomas C. Dowling; Reginald F Frye; DS Fraley; Gary R Matzke
Comparison of iothalamate clearance methods for measuring GFR.
Pharmacotherapy 1999;19(8):943-50.
1999: Patricia D Kroboth; Firoozeh S Salek; A L Pittenger; Tanya J Fabian; Reginald F Frye
DHEA and DHEA-S: a review.
Journal of clinical pharmacology 1999;39(4):327-48.
1999: Harold J Manley; George R Bailie; R D Asher; George Eisele; Reginald F Frye
Pharmacokinetics of intermittent intraperitoneal cefazolin in continuous ambulatory peritoneal dialysis patients.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 1999;19(1):65-70.
1999: Darren W Grabe; George R Bailie; George Eisele; Reginald F Frye
Pharmacokinetics of intermittent intraperitoneal ceftazidime.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;33(1):111-7.
1998: Thomas C. Dowling; Reginald F Frye; Michael A Zemaitis
Simultaneous determination of p-aminohippuric acid, acetyl-p-aminohippuric acid and iothalamate in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1998;716(1-2):305-13.
1998: Adedayo Adedoyin; Reginald F Frye; K Mauro; Robert A Branch
Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail.
British journal of clinical pharmacology 1998;46(3):215-9.
1998: Michael A Marx; Reginald F Frye; Gary R Matzke; Thomas A Golper
Cefazolin as empiric therapy in hemodialysis-related infections: efficacy and blood concentrations.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1998;32(3):410-4.
1998: Melanie S Joy; Gary R Matzke; Reginald F Frye; Paul M Palevsky
Determinants of vancomycin clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1998;31(6):1019-27.
1998: Gilbert J Burckart; Reginald F Frye; P Kelly; Robert A Branch; A Jain; J J Fung; T E Starzl; Raman Venkataramanan
Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation.
Clinical pharmacology and therapeutics 1998;63(3):296-302.
1998: Reginald F Frye; Adedayo Adedoyin; K Mauro; Gary R Matzke; Robert A Branch
Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose and phenotypic trait measure.
Journal of clinical pharmacology 1998;38(1):82-9.
1997: Reginald F Frye; Gary R Matzke; Adedayo Adedoyin; J A Porter; Robert A Branch
Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes.
Clinical pharmacology and therapeutics 1997;62(4):365-76.
1997: PP Gleason; Reginald F Frye; T O'Toole
Debilitating reaction following the initial dose of tramadol.
The Annals of pharmacotherapy 1997;31(10):1150-2.
1997: Gary R Matzke; Reginald F Frye
Drug administration in patients with renal insufficiency. Minimising renal and extrarenal toxicity.
Drug safety : an international journal of medical toxicology and drug experience 1997;16(3):205-31.
1997: Reginald F Frye; Gary R Matzke; Robert R Schade; R Dixon; Mordecai Rabinovitz
Effects of liver disease on the disposition of the opioid antagonist nalmefene.
Clinical pharmacology and therapeutics 1997;61(1):15-23.
1996: Reginald F Frye; D D Stiff
Determination of chlorzoxazone and 6-hydroxychlorzoxazone in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1996;686(2):291-6.
1996: Reginald F Frye; Gary R Matzke; N S Jallad; J A Wilhelm; G B Bikhazi
The effect of age on the pharmacokinetics of the opioid antagonist nalmefene.
British journal of clinical pharmacology 1996;42(3):301-6.
1996: A H Karara; Reginald F Frye; P E Hayes; M L Weaver; W T Robinson; R M Rault; Gary R Matzke
Pharmacokinetics of abecarnil in patients with renal insufficiency.
Clinical pharmacology and therapeutics 1996;59(5):520-8.
1996: Reginald F Frye; Robert A Branch
Improved high-performance liquid chromatographic determination of debrisoquine and 4-hydroxydebrisoquine in human urine following direct injection.
Journal of chromatography. B, Biomedical applications 1996;677(1):178-82.
1996: Gary R Matzke; Reginald F Frye; A C Alexander; R Reynolds; R Dixon; J Johnston; R M Rault
The effect of renal insufficiency and hemodialysis on the pharmacokinetics of nalmefene.
Journal of clinical pharmacology 1996;36(2):144-51.
1993: David Kisor; Reginald F Frye; Kenneth A Kudsk
Estimation of the hepatic extraction ratio of indocyanine green in swine.
Clinical science (London, England : 1979) 1993;84(6):681-5.
1993: D D Stiff; Reginald F Frye; Robert A Branch
Sensitive high-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in plasma.
Journal of chromatography 1993;613(1):127-31.