Elaine Fuchs

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Nguyen Hoang; Merrill Bradley J; Polak Lisa; Nikolova Maria; Rendl Michael; Shaver Timothy M; Pasolli H Amalia; Fuchs Elaine
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
Fuchs Elaine
Building confidence: the transition from student to professor.
Fuchs Elaine
Finding one's niche in the skin.

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All Publications

2009: Nguyen Hoang; Merrill Bradley J; Polak Lisa; Nikolova Maria; Rendl Michael; Shaver Timothy M; Pasolli H Amalia; Fuchs Elaine
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
Nature genetics 2009;41(10):1068-75.
2009: Fuchs Elaine
Building confidence: the transition from student to professor.
Nature cell biology 2009;11(7):786.
2009: Fuchs Elaine
Finding one's niche in the skin.
Cell stem cell 2009;4(6):499-502.
2009: Fuchs Elaine
The tortoise and the hair: slow-cycling cells in the stem cell race.
Cell 2009;137(5):811-9.
2009: Ezhkova Elena; Pasolli H Amalia; Parker Joel S; Stokes Nicole; Su I-hsin; Hannon Gregory; Tarakhovsky Alexander; Fuchs Elaine
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.
Cell 2009;136(6):1122-35.
2009: Greco Valentina; Chen Ting; Rendl Michael; Schober Markus; Pasolli H Amalia; Stokes Nicole; Dela Cruz-Racelis June; Fuchs Elaine
A two-step mechanism for stem cell activation during hair regeneration.
Cell stem cell 2009;4(2):155-69.
2009: Yi Rui; Pasolli H Amalia; Landthaler Markus; Hafner Markus; Ojo Tolulope; Sheridan Robert; Sander Chris; O'Carroll Donal; Stoffel Markus; Tuschl Thomas; Fuchs Elaine
DGCR8-dependent microRNA biogenesis is essential for skin development.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):498-502.
2008: Devenport Danelle; Fuchs Elaine
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles.
Nature cell biology 2008;10(11):1257-68.
2008: Wu Xiaoyang; Kodama Atsuko; Fuchs Elaine
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.
Cell 2008;135(1):137-48.
2008: Wang Xuan; Pasolli H Amalia; Williams Trevor; Fuchs Elaine
AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.
The Journal of cell biology 2008;183(1):37-48.
2008: Tinkle Christopher L; Pasolli H Amalia; Stokes Nicole; Fuchs Elaine
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15405-10.
2008: Perez-Moreno Mirna; Song Weimin; Pasolli H Amalia; Williams Scott E; Fuchs Elaine
Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15399-404.
2008: Pasolli Ha; Horsley V; Tumbar T; Blanpain C; Lowry W; Greco V; Fuchs E
Beauty is skin deep: imaging and characterization of skin stem cells.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2008;14 Suppl 2():1468-9.
2008: Nowak Jonathan A; Polak Lisa; Pasolli H Amalia; Fuchs Elaine
Hair follicle stem cells are specified and function in early skin morphogenesis.
Cell stem cell 2008;3(1):33-43.
2008: Fuchs Elaine; Horsley Valerie
More than one way to skin . . .
Genes & development 2008;22(8):976-85.
2008: Yi Rui; Poy Matthew N; Stoffel Markus; Fuchs Elaine
A skin microRNA promotes differentiation by repressing 'stemness'.
Nature 2008;452(7184):225-9.
2008: Rendl Michael; Polak Lisa; Fuchs Elaine
BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties.
Genes & development 2008;22(4):543-57.
2008: Horsley Valerie; Aliprantis Antonios O; Polak Lisa; Glimcher Laurie H; Fuchs Elaine
NFATc1 balances quiescence and proliferation of skin stem cells.
Cell 2008;132(2):299-310.
2008: Fuchs Elaine
Skin stem cells: rising to the surface.
The Journal of cell biology 2008;180(2):273-84.
2008: Fuchs E; Nowak J A
Building epithelial tissues from skin stem cells.
Cold Spring Harbor symposia on quantitative biology 2008;73():333-50.
2007: Guasch Géraldine; Schober Markus; Pasolli H Amalia; Conn Emily Belmont; Polak Lisa; Fuchs Elaine
Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia.
Cancer cell 2007;12(4):313-27.
2007: Horsley Valerie; Fuchs Elaine
Reprogramming somatic cells to their embryonic state.
HFSP journal 2007;1(2):89-93.
2007: Kobielak Krzysztof; Stokes Nicole; de la Cruz June; Polak Lisa; Fuchs Elaine
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(24):10063-8.
2007: Schober Markus; Raghavan Srikala; Nikolova Maria; Polak Lisa; Pasolli H Amalia; Beggs Hilary E; Reichardt Louis F; Fuchs Elaine
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics.
The Journal of cell biology 2007;176(5):667-80.
2007: Fuchs Elaine
Scratching the surface of skin development.
Nature 2007;445(7130):834-42.
2007: Li Jinsong; Greco Valentina; Guasch Géraldine; Fuchs Elaine; Mombaerts Peter
Mice cloned from skin cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2738-43.
2007: Blanpain Cédric; Horsley Valerie; Fuchs Elaine
Epithelial stem cells: turning over new leaves.
Cell 2007;128(3):445-58.
2007: Lechler Terry; Fuchs Elaine
Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
The Journal of cell biology 2007;176(2):147-54.
2006: Perez-Moreno Mirna; Fuchs Elaine
Catenins: keeping cells from getting their signals crossed.
Developmental cell 2006;11(5):601-12.
2006: Blanpain Cédric; Lowry William E; Pasolli H Amalia; Fuchs Elaine
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Genes & development 2006;20(21):3022-35.
2006: Nguyen Hoang; Rendl Michael; Fuchs Elaine
Tcf3 governs stem cell features and represses cell fate determination in skin.
Cell 2006;127(1):171-83.
2006: Horsley Valerie; O'Carroll Dónal; Tooze Reuben; Ohinata Yasuhide; Saitou Mitinori; Obukhanych Tetyana; Nussenzweig Michel; Tarakhovsky Alexander; Fuchs Elaine
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.
Cell 2006;126(3):597-609.
2006: Haegebarth Andrea; Bie Wenjun; Yang Ruyan; Crawford Susan E; Vasioukhin Valeri; Fuchs Elaine; Tyner Angela L
Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.
Molecular and cellular biology 2006;26(13):4949-57.
2006: Rhee Horace; Polak Lisa; Fuchs Elaine
Lhx2 maintains stem cell character in hair follicles.
Science (New York, N.Y.) 2006;312(5782):1946-9.
2006: Yi Rui; O'Carroll Dónal; Pasolli Hilda A; Zhang Zhihong; Dietrich Fred S; Tarakhovsky Alexander; Fuchs Elaine
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.
Nature genetics 2006;38(3):356-62.
2006: Perez-Moreno Mirna; Davis Michael A; Wong Ellen; Pasolli H Amalia; Reynolds Albert B; Fuchs Elaine
p120-catenin mediates inflammatory responses in the skin.
Cell 2006;124(3):631-44.
2006: Kobielak Agnieszka; Fuchs Elaine
Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2322-7.
2006: Wang Xuan; Bolotin Diana; Chu David H; Polak Lisa; Williams Trevor; Fuchs Elaine
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
The Journal of cell biology 2006;172(3):409-21.
2006: Blanpain Cédric; Fuchs Elaine
Epidermal stem cells of the skin.
Annual review of cell and developmental biology 2006;22():339-73.
2005: Guasch Geraldine; Fuchs Elaine
Mice in the world of stem cell biology.
Nature genetics 2005;37(11):1201-6.
2005: Rendl Michael; Lewis Lisa; Fuchs Elaine
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle.
PLoS biology 2005;3(11):e331.
2005: Lechler Terry; Fuchs Elaine
Asymmetric cell divisions promote stratification and differentiation of mammalian skin.
Nature 2005;437(7056):275-80.
2005: Alonso Laura; Okada Hitoshi; Pasolli Hilda Amalia; Wakeham Andrew; You-Ten Annick Itie; Mak Tak W; Fuchs Elaine
Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle.
The Journal of cell biology 2005;170(4):559-70.
2005: Lowry William E; Blanpain Cedric; Nowak Jonathan A; Guasch Geraldine; Lewis Lisa; Fuchs Elaine
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.
Genes & development 2005;19(13):1596-611.
2005: Jamora Colin; Lee Pedro; Kocieniewski Pawel; Azhar Mohamad; Hosokawa Ryoichi; Chai Yang; Fuchs Elaine
A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis.
PLoS biology 2005;3(1):e11.
2004: Kodama Atsuko; Lechler Terry; Fuchs Elaine
Coordinating cytoskeletal tracks to polarize cellular movements.
The Journal of cell biology 2004;167(2):203-7.
2004: Blanpain Cedric; Lowry William E; Geoghegan Andrea; Polak Lisa; Fuchs Elaine
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche.
Cell 2004;118(5):635-48.
2004: Kobielak Agnieszka; Fuchs Elaine
Alpha-catenin: at the junction of intercellular adhesion and actin dynamics.
Nature reviews. Molecular cell biology 2004;5(8):614-25.
2004: Fuchs Elaine; Tumbar Tudorita; Guasch Geraldine
Socializing with the neighbors: stem cells and their niche.
Cell 2004;116(6):769-78.
2004: Tinkle Christopher L; Lechler Terry; Pasolli H Amalia; Fuchs Elaine
Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):552-7.
2004: Tumbar Tudorita; Guasch Geraldine; Greco Valentina; Blanpain Cedric; Lowry William E; Rendl Michael; Fuchs Elaine
Defining the epithelial stem cell niche in skin.
Science (New York, N.Y.) 2004;303(5656):359-63.
2004: Merrill Bradley J; Pasolli H Amalia; Polak Lisa; Rendl Michael; García-García Maria J; Anderson Kathryn V; Fuchs Elaine
Tcf3: a transcriptional regulator of axis induction in the early embryo.
Development (Cambridge, England) 2004;131(2):263-74.
2004: Kobielak Agnieszka; Pasolli H Amalia; Fuchs Elaine
Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables.
Nature cell biology 2004;6(1):21-30.
2003: Kobielak Krzysztof; Pasolli H Amalia; Alonso Laura; Polak Lisa; Fuchs Elaine
Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.
The Journal of cell biology 2003;163(3):609-23.
2003: Kodama Atsuko; Karakesisoglou Iakowos; Wong Ellen; Vaezi Alec; Fuchs Elaine
ACF7: an essential integrator of microtubule dynamics.
Cell 2003;115(3):343-54.
2003: Castelo-Branco Gonçalo; Wagner Joseph; Rodriguez Francisco J; Kele Julianna; Sousa Kyle; Rawal Nina; Pasolli Hilda Amalia; Fuchs Elaine; Kitajewski Jan; Arenas Ernest
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12747-52.
2003: Raghavan Srikala; Vaezi Alec; Fuchs Elaine
A role for alphabeta1 integrins in focal adhesion function and polarized cytoskeletal dynamics.
Developmental cell 2003;5(3):415-27.
2003: Kaufman Charles K; Zhou Ping; Pasolli H Amalia; Rendl Michael; Bolotin Diana; Lim Kim-Chew; Dai Xing; Alegre Maria-Luisa; Fuchs Elaine
GATA-3: an unexpected regulator of cell lineage determination in skin.
Genes & development 2003;17(17):2108-22.
2003: Alonso Laura; Fuchs Elaine
Stem cells of the skin epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2003;100 Suppl 1():11830-5.
2003: Alonso Laura; Fuchs Elaine
Stem cells in the skin: waste not, Wnt not.
Genes & development 2003;17(10):1189-200.
2003: Jamora Colin; DasGupta Ramanuj; Kocieniewski Pawel; Fuchs Elaine
Links between signal transduction, transcription and adhesion in epithelial bud development.
Nature 2003;422(6929):317-22.
2003: Perez-Moreno Mirna; Jamora Colin; Fuchs Elaine
Sticky business: orchestrating cellular signals at adherens junctions.
Cell 2003;112(4):535-48.
2002: Vaezi Alec; Bauer Christoph; Vasioukhin Valeri; Fuchs Elaine
Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium.
Developmental cell 2002;3(3):367-81.
2002: DasGupta Ramanuj; Rhee Horace; Fuchs Elaine
A developmental conundrum: a stabilized form of beta-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells.
The Journal of cell biology 2002;158(2):331-44.
2002: Kaufman Charles K; Sinha Satrajit; Bolotin Diana; Fan Jie; Fuchs Elaine
Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificity.
Molecular and cellular biology 2002;22(12):4293-308.
2002: Li Baoan; Mackay Douglas R; Dai Qian; Li Tony W H; Nair Mahalakshmi; Fallahi Magid; Schonbaum Christopher P; Fantes Judith; Mahowald Anthony P; Waterman Marian L; Fuchs Elaine; Dai Xing
The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6064-9.
2002: Jamora Colin; Fuchs Elaine
Intercellular adhesion, signalling and the cytoskeleton.
Nature cell biology 2002;4(4):E101-8.
2002: Fuchs Elaine; Raghavan Srikala
Getting under the skin of epidermal morphogenesis.
Nature reviews. Genetics 2002;3(3):199-209.
2002: Forsythe Sean M; Kogut Paul C; McConville John F; Fu Yiping; McCauley Joel A; Halayko Andrew J; Liu Hong Wei; Kao Allen; Fernandes Darren J; Bellam Shashi; Fuchs Elaine; Sinha Satrajit; Bell Graeme I; Camoretti-Mercado Blanca; Solway Julian
Structure and transcription of the human m3 muscarinic receptor gene.
American journal of respiratory cell and molecular biology 2002;26(3):298-305.
2001: Vasioukhin V; Bowers E; Bauer C; Degenstein L; Fuchs E
Desmoplakin is essential in epidermal sheet formation.
Nature cell biology 2001;3(12):1076-85.
2001: Fuchs E; Merrill B J; Jamora C; DasGupta R
At the roots of a never-ending cycle.
Developmental cell 2001;1(1):13-25.
2001: Merrill B J; Gat U; DasGupta R; Fuchs E
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.
Genes & development 2001;15(13):1688-705.
2001: Gallicano G I; Bauer C; Fuchs E
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature.
Development (Cambridge, England) 2001;128(6):929-41.
2001: Vasioukhin V; Bauer C; Degenstein L; Wise B; Fuchs E
Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin.
Cell 2001;104(4):605-17.
2001: Sinha S; Fuchs E
Identification and dissection of an enhancer controlling epithelial gene expression in skin.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2455-60.
2001: Vasioukhin V; Fuchs E
Actin dynamics and cell-cell adhesion in epithelia.
Current opinion in cell biology 2001;13(1):76-84.
2001: Fuchs E; Karakesisoglou I
Bridging cytoskeletal intersections.
Genes & development 2001;15(1):1-14.
2000: Raghavan S; Bauer C; Mundschau G; Li Q; Fuchs E
Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination.
The Journal of cell biology 2000;150(5):1149-60.
2000: Camoretti-Mercado B; Liu H W; Halayko A J; Forsythe S M; Kyle J W; Li B; Fu Y; McConville J; Kogut P; Vieira J E; Patel N M; Hershenson M B; Fuchs E; Sinha S; Miano J M; Parmacek M S; Burkhardt J K; Solway J
Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor.
The Journal of biological chemistry 2000;275(39):30387-93.
2000: Kaufman C K; Fuchs E
It's got you covered. NF-kappaB in the epidermis.
The Journal of cell biology 2000;149(5):999-1004.
2000: Karakesisoglou I; Yang Y; Fuchs E
An epidermal plakin that integrates actin and microtubule networks at cellular junctions.
The Journal of cell biology 2000;149(1):195-208.
2000: Sinha S; Degenstein L; Copenhaver C; Fuchs E
Defining the regulatory factors required for epidermal gene expression.
Molecular and cellular biology 2000;20(7):2543-55.
2000: Vasioukhin V; Bauer C; Yin M; Fuchs E
Directed actin polymerization is the driving force for epithelial cell-cell adhesion.
Cell 2000;100(2):209-19.
2000: Fuchs E; Segre J A
Stem cells: a new lease on life.
Cell 2000;100(1):143-55.
1999: DasGupta R; Fuchs E
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.
Development (Cambridge, England) 1999;126(20):4557-68.
1999: Fuchs E; Yang Y
Crossroads on cytoskeletal highways.
Cell 1999;98(5):547-50.
1999: Segre J A; Bauer C; Fuchs E
Klf4 is a transcription factor required for establishing the barrier function of the skin.
Nature genetics 1999;22(4):356-60.
1999: Yang Y; Bauer C; Strasser G; Wollman R; Julien J P; Fuchs E
Integrators of the cytoskeleton that stabilize microtubules.
Cell 1999;98(2):229-38.
1999: Vasioukhin V; Degenstein L; Wise B; Fuchs E
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8551-6.
1999: Pena J C; Kelekar A; Fuchs E V; Thompson C B
Manipulation of outer root sheath cell survival perturbs the hair-growth cycle.
The EMBO journal 1999;18(13):3596-603.
1999: Chan E F; Gat U; McNiff J M; Fuchs E
A common human skin tumour is caused by activating mutations in beta-catenin.
Nature genetics 1999;21(4):410-3.
1998: Gallicano G I; Kouklis P; Bauer C; Yin M; Vasioukhin V; Degenstein L; Fuchs E
Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage.
The Journal of cell biology 1998;143(7):2009-22.
1998: Gat U; DasGupta R; Degenstein L; Fuchs E
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin.
Cell 1998;95(5):605-14.
1998: Dai X; Schonbaum C; Degenstein L; Bai W; Mahowald A; Fuchs E
The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice.
Genes & development 1998;12(21):3452-63.
1998: Hutton E; Paladini R D; Yu Q C; Yen M; Coulombe P A; Fuchs E
Functional differences between keratins of stratified and simple epithelia.
The Journal of cell biology 1998;143(2):487-99.
1998: Smith E A; Fuchs E
Defining the interactions between intermediate filaments and desmosomes.
The Journal of cell biology 1998;141(5):1229-41.
1998: Fuchs E; Cleveland D W
A structural scaffolding of intermediate filaments in health and disease.
Science (New York, N.Y.) 1998;279(5350):514-9.
1998: Fuchs E
Beauty is skin deep: the fascinating biology of the epidermis and its appendages.
Harvey lectures 1998;94():47-77.
1997: Fuchs E; Dowling J; Segre J; Lo S H; Yu Q C
Integrators of epidermal growth and differentiation: distinct functions for beta 1 and beta 4 integrins.
Current opinion in genetics & development 1997;7(5):672-82.
1997: Dowling J; Yang Y; Wollmann R; Reichardt L F; Fuchs E
Developmental expression of BPAG1-n: insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum mice.
Developmental biology 1997;187(2):131-42.
1997: Pena J C; Fuchs E; Thompson C B
Bcl-x expression influences keratinocyte cell survival but not terminal differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(6):619-29.
1997: Yang Z; Gallicano G I; Yu Q C; Fuchs E
An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids.
The Journal of cell biology 1997;137(3):657-69.
1997: Lo S H; Yu Q C; Degenstein L; Chen L B; Fuchs E
Progressive kidney degeneration in mice lacking tensin.
The Journal of cell biology 1997;136(6):1349-61.
1997: Fuchs E
Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton.
Molecular biology of the cell 1997;8(2):189-203.
1997: Wang X; Zinkel S; Polonsky K; Fuchs E
Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):219-26.
1997: Fuchs E; Yang Y; Dowling J; Kouklis P; Smith E; Guo L; Yu Q C
Intermediate filament linker proteins.
Society of General Physiologists series 1997;52():141-8.
1996: Uttam J; Hutton E; Coulombe P A; Anton-Lamprecht I; Yu Q C; Gedde-Dahl T; Fine J D; Fuchs E
The genetic basis of epidermolysis bullosa simplex with mottled pigmentation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(17):9079-84.
1996: Yang Y; Dowling J; Yu Q C; Kouklis P; Cleveland D W; Fuchs E
An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments.
Cell 1996;86(4):655-65.
1996: Dowling J; Yu Q C; Fuchs E
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.
The Journal of cell biology 1996;134(2):559-72.
1996: Allen E; Yu Q C; Fuchs E
Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation.
The Journal of cell biology 1996;133(6):1367-82.
1996: Chan Y M; Cheng J; Gedde-Dahl T; Niemi K M; Fuchs E
Genetic analysis of a severe case of Dowling-Meara epidermolysis bullosa simplex.
The Journal of investigative dermatology 1996;106(2):327-34.
1996: Guo L; Degenstein L; Fuchs E
Keratinocyte growth factor is required for hair development but not for wound healing.
Genes & development 1996;10(2):165-75.
1996: Fuchs E
The cytoskeleton and disease: genetic disorders of intermediate filaments.
Annual review of genetics 1996;30():197-231.
1995: Lloyd C; Yu Q C; Cheng J; Turksen K; Degenstein L; Hutton E; Fuchs E
The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.
The Journal of cell biology 1995;129(5):1329-44.
1995: Guo L; Degenstein L; Dowling J; Yu Q C; Wollmann R; Perman B; Fuchs E
Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration.
Cell 1995;81(2):233-43.
1995: Zhou P; Byrne C; Jacobs J; Fuchs E
Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.
Genes & development 1995;9(6):700-13.
1995: Letai A; Fuchs E
The importance of intramolecular ion pairing in intermediate filaments.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):92-6.
1995: Aneskievich B J; Fuchs E
The A/B domain of truncated retinoic acid receptors can block differentiation and promote features of malignancy.
Journal of cell science 1995;108 ( Pt 1)():195-205.
1995: Fuchs E
Keratins and the skin.
Annual review of cell and developmental biology 1995;11():123-53.
1994: Paller A S; Syder A J; Chan Y M; Yu Q C; Hutton E; Tadini G; Fuchs E
Genetic and clinical mosaicism in a type of epidermal nevus.
The New England journal of medicine 1994;331(21):1408-15.
1994: Fuchs E; Coulombe P; Cheng J; Chan Y M; Hutton E; Syder A; Degenstein L; Yu Q C; Letai A; Vassar R
Genetic bases of epidermolysis bullosa simplex and epidermolytic hyperkeratosis.
The Journal of investigative dermatology 1994;103(5 Suppl):25S-30S.
1994: Kouklis P D; Hutton E; Fuchs E
Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.
The Journal of cell biology 1994;127(4):1049-60.
1994: Chan Y; Anton-Lamprecht I; Yu Q C; Jäckel A; Zabel B; Ernst J P; Fuchs E
A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein.
Genes & development 1994;8(21):2574-87.
1994: Fuchs E; Byrne C
The epidermis: rising to the surface.
Current opinion in genetics & development 1994;4(5):725-36.
1994: Fuchs E; Chan Y M; Paller A S; Yu Q C
Cracks in the foundation: keratin filaments and genetic disease.
Trends in cell biology 1994;4(9):321-6.
1994: Byrne C; Tainsky M; Fuchs E
Programming gene expression in developing epidermis.
Development (Cambridge, England) 1994;120(9):2369-83.
1994: Faus I; Hsu H J; Fuchs E
Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.
Molecular and cellular biology 1994;14(5):3263-75.
1994: Fuchs E
Intermediate filaments and disease: mutations that cripple cell strength.
The Journal of cell biology 1994;125(3):511-6.
1994: Chan Y M; Yu Q C; LeBlanc-Straceski J; Christiano A; Pulkkinen L; Kucherlapati R S; Uitto J; Fuchs E
Mutations in the non-helical linker segment L1-2 of keratin 5 in patients with Weber-Cockayne epidermolysis bullosa simplex.
Journal of cell science 1994;107 ( Pt 4)():765-74.
1994: Syder A J; Yu Q C; Paller A S; Giudice G; Pearson R; Fuchs E
Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity.
The Journal of clinical investigation 1994;93(4):1533-42.
1994: Fuchs E; Weber K
Intermediate filaments: structure, dynamics, function, and disease.
Annual review of biochemistry 1994;63():345-82.
1993: Teng M N; Turksen K; Jacobs C A; Fuchs E; Schreiber H
Prevention of runting and cachexia by a chimeric TNF receptor-Fc protein.
Clinical immunology and immunopathology 1993;69(2):215-22.
1993: Chan Y M; Yu Q C; Fine J D; Fuchs E
The genetic basis of Weber-Cockayne epidermolysis bullosa simplex.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7414-8.
1993: McCormick M B; Kouklis P; Syder A; Fuchs E
The roles of the rod end and the tail in vimentin IF assembly and IF network formation.
The Journal of cell biology 1993;122(2):395-407.
1993: Byrne C; Fuchs E
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice.
Molecular and cellular biology 1993;13(6):3176-90.
1993: Letai A; Coulombe P A; McCormick M B; Yu Q C; Hutton E; Fuchs E
Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3197-201.
1993: Guo L; Yu Q C; Fuchs E
Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.
The EMBO journal 1993;12(3):973-86.
1993: Fuchs E
Epidermal differentiation and keratin gene expression.
Journal of cell science. Supplement 1993;17():197-208.
1992: Fuchs E
Genetic skin disorders of keratin.
The Journal of investigative dermatology 1992;99(6):671-4.
1992: Aneskievich B J; Fuchs E
Terminal differentiation in keratinocytes involves positive as well as negative regulation by retinoic acid receptors and retinoid X receptors at retinoid response elements.
Molecular and cellular biology 1992;12(11):4862-71.
1992: Vassar R; Hutton M E; Fuchs E
Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.
Molecular and cellular biology 1992;12(10):4643-53.
1992: Wilson A K; Coulombe P A; Fuchs E
The roles of K5 and K14 head, tail, and R/K L L E G E domains in keratin filament assembly in vitro.
The Journal of cell biology 1992;119(2):401-14.
1992: Cheng J; Syder A J; Yu Q C; Letai A; Paller A S; Fuchs E
The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes.
Cell 1992;70(5):811-9.
1992: Fuchs E; Esteves R A; Coulombe P A
Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6906-10.
1992: Cheng J; Turksen K; Yu Q C; Schreiber H; Teng M; Fuchs E
Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.
Genes & development 1992;6(8):1444-56.
1992: Fuchs E; Coulombe P A
Of mice and men: genetic skin diseases of keratin.
Cell 1992;69(6):899-902.
1992: Turksen K; Kupper T; Degenstein L; Williams I; Fuchs E
Interleukin 6: insights to its function in skin by overexpression in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5068-72.
1992: Letai A; Coulombe P A; Fuchs E
Do the ends justify the mean? Proline mutations at the ends of the keratin coiled-coil rod segment are more disruptive than internal mutations.
The Journal of cell biology 1992;116(5):1181-95.
1992: Albers K; Fuchs E
The molecular biology of intermediate filament proteins.
International review of cytology 1992;134():243-79.
1991: Coulombe P A; Hutton M E; Vassar R; Fuchs E
A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases.
The Journal of cell biology 1991;115(6):1661-74.
1991: Fuchs E
Keratin genes, epidermal differentiation and animal models for the study of human skin diseases.
Biochemical Society transactions 1991;19(4):1112-5.
1991: Coulombe P A; Hutton M E; Letai A; Hebert A; Paller A S; Fuchs E
Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses.
Cell 1991;66(6):1301-11.
1991: Leask A; Byrne C; Fuchs E
Transcription factor AP2 and its role in epidermal-specific gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):7948-52.
1991: Turksen K; Choi Y; Fuchs E
Transforming growth factor alpha induces collagen degradation and cell migration in differentiating human epidermal raft cultures.
Cell regulation 1991;2(8):613-25.
1991: Stellmach V; Leask A; Fuchs E
Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4582-6.
1991: McCormick M B; Coulombe P A; Fuchs E
Sorting out IF networks: consequences of domain swapping on IF recognition and assembly.
The Journal of cell biology 1991;113(5):1111-24.
1991: Vassar R; Fuchs E
Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.
Genes & development 1991;5(5):714-27.
1991: Vassar R; Coulombe P A; Degenstein L; Albers K; Fuchs E
Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease.
Cell 1991;64(2):365-80.
1991: Rosenberg M; Fuchs E; Le Beau M M; Eddy R L; Shows T B
Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.
Cytogenetics and cell genetics 1991;57(1):33-8.
1990: Fuchs E
Epidermal differentiation: the bare essentials.
The Journal of cell biology 1990;111(6 Pt 2):2807-14.
1990: Coulombe P A; Chan Y M; Albers K; Fuchs E
Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro.
The Journal of cell biology 1990;111(6 Pt 2):3049-64.
1990: Leask A; Rosenberg M; Vassar R; Fuchs E
Regulation of a human epidermal keratin gene: sequences and nuclear factors involved in keratinocyte-specific transcription.
Genes & development 1990;4(11):1985-98.
1990: Choi Y; Fuchs E
TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.
Cell regulation 1990;1(11):791-809.
1990: Coulombe P A; Fuchs E
Elucidating the early stages of keratin filament assembly.
The Journal of cell biology 1990;111(1):153-69.
1989: Stellmach V M; Fuchs E
Exploring the mechanisms underlying cell type-specific and retinoid-mediated expression of keratins.
The New biologist 1989;1(3):305-17.
1989: Stoler A; Duvic M; Fuchs E
Unusual patterns of keratin expression in the overlying epidermis of patients with dermatofibromas: biochemical alterations in the epidermis as a consequence of dermal tumors.
The Journal of investigative dermatology 1989;93(6):728-38.
1989: Coulombe P A; Kopan R; Fuchs E
Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation.
The Journal of cell biology 1989;109(5):2295-312.
1989: Lersch R; Stellmach V; Stocks C; Giudice G; Fuchs E
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.
Molecular and cellular biology 1989;9(9):3685-97.
1989: Kopan R; Fuchs E
The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells.
The Journal of cell biology 1989;109(1):295-307.
1989: Albers K; Fuchs E
Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments.
The Journal of cell biology 1989;108(4):1477-93.
1989: Vassar R; Rosenberg M; Ross S; Tyner A; Fuchs E
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(5):1563-7.
1989: Kopan R; Fuchs E
A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin.
Genes & development 1989;3(1):1-15.
1988: McCance D J; Kopan R; Fuchs E; Laimins L A
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7169-73.
1988: Glass C; Fuchs E
Isolation, sequence, and differential expression of a human K7 gene in simple epithelial cells.
The Journal of cell biology 1988;107(4):1337-50.
1988: Stoler A; Kopan R; Duvic M; Fuchs E
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.
The Journal of cell biology 1988;107(2):427-46.
1988: Rosenberg M; RayChaudhury A; Shows T B; Le Beau M M; Fuchs E
A group of type I keratin genes on human chromosome 17: characterization and expression.
Molecular and cellular biology 1988;8(2):722-36.
1988: Lersch R; Fuchs E
Sequence and expression of a type II keratin, K5, in human epidermal cells.
Molecular and cellular biology 1988;8(1):486-93.
1987: Kim K H; Stellmach V; Javors J; Fuchs E
Regulation of human mesothelial cell differentiation: opposing roles of retinoids and epidermal growth factor in the expression of intermediate filament proteins.
The Journal of cell biology 1987;105(6 Pt 2):3039-51.
1987: Fuchs E; Tyner A L; Giudice G J; Marchuk D; RayChaudhury A; Rosenberg M
The human keratin genes and their differential expression.
Current topics in developmental biology 1987;22():5-34.
1986: RayChaudhury A; Marchuk D; Lindhurst M; Fuchs E
Three tightly linked genes encoding human type I keratins: conservation of sequence in the 5'-untranslated leader and 5'-upstream regions of coexpressed keratin genes.
Molecular and cellular biology 1986;6(2):539-48.

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