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Gudrun Antoons

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Vincent J A Bourgonje; Nicolas Doisne; Marien Houtman; Lars Kattner; Semir Ozdemir; Erik Rauch; Karin R Sipido; Anita Sztojkov-Ivanov; Roel van der Nagel; Toon A B van Veen; Andras Varro; Marc A Vos; Istvan Zupko; Karoly Acsai; Jet D M Beekman; Virginie Bito; Gudrun Antoons
Combined na+/ca2+ exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.
Karin R Sipido; Károly Acsai; Gudrun Antoons; Virginie Bito; Niall Macquaide
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.
Virginie Bito; Barnabas Gellen; Niall Macquaide; Jean-Jacques Mercadier; Mylène Pezet; Patricia Rouet-Benzineb; Gudrun Antoons; Liesbeth Biesmans; Karin R Sipido
FKBP12.6 overexpression does not protect against remodelling after myocardial infarction.

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All Publications

2013: Vincent J A Bourgonje; Nicolas Doisne; Marien Houtman; Lars Kattner; Semir Ozdemir; Erik Rauch; Karin R Sipido; Anita Sztojkov-Ivanov; Roel van der Nagel; Toon A B van Veen; Andras Varro; Marc A Vos; Istvan Zupko; Karoly Acsai; Jet D M Beekman; Virginie Bito; Gudrun Antoons
Combined na+/ca2+ exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.
Circulation. Arrhythmia and electrophysiology 2013;6(2):371-9.
2013: Karin R Sipido; Károly Acsai; Gudrun Antoons; Virginie Bito; Niall Macquaide
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.
Advances in experimental medicine and biology 2013;961():375-83.
2013: Virginie Bito; Barnabas Gellen; Niall Macquaide; Jean-Jacques Mercadier; Mylène Pezet; Patricia Rouet-Benzineb; Gudrun Antoons; Liesbeth Biesmans; Karin R Sipido
FKBP12.6 overexpression does not protect against remodelling after myocardial infarction.
Experimental physiology 2013;98(1):134-48.
2012: Vincent J A Bourgonje; Leon J De Windt; Marien J C Houtman; Lars F Miedema; Marieke Schoenmakers; Karin R Sipido; Roel van der Nagel; Toon A B van Veen; Gudrun Antoons; Jet D M Beekman; Marc A Vos
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(11):1875-83.
2012: Leonid Livshitz; Karoly Acsai; Gudrun Antoons; Karin Sipido; Yoram Rudy
Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes.
The Journal of physiology 2012;590(Pt 18):4423-46.
2012: Gudrun Antoons; Rik Willems; Karin R Sipido
Alternative strategies in arrhythmia therapy: evaluation of Na/Ca exchange as an anti-arrhythmic target.
Pharmacology & therapeutics 2012;134(1):26-42.
2012: Nan Wang; Karin R Sipido; Gudrun Antoons; Mélissa Bol; Feliksas F Bukauskas; Manuelle De Bock; Elke Decrock; William Howard Evans; Ashish K Gadicherla; Luc Leybaert
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation.
Basic research in cardiology 2012;107(6):304.
2011: Mohamed Boulaksil; Jacques M T de Bakker; Teun P de Boer; Marien J C Houtman; Jerome G Jungschleger; Jos G Maessen; Michiel van der Heyden; Ferenc F van der Hulst; Harold V M van Rijen; Toon A B van Veen; Gudrun Antoons; Jet D M Beekman; Ronald Wilders; Marc A Vos
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
Circulation. Arrhythmia and electrophysiology 2011;4(4):566-76.
2011: Vincent Floré; Patricia Holemans; Peter Oosterhoff; Karin R Sipido; Marc A Vos; Gudrun Antoons; Piet Claus; Rik Willems
Microvolt T-wave alternans and beat-to-beat variability of repolarization during early postischemic remodeling in a pig heart.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(7):1050-7.
2011: Elke De Vuyst; Kerstin Boengler; Gudrun Antoons; Karin R Sipido; Rainer Schulz; Luc Leybaert
Pharmacological modulation of connexin-formed channels in cardiac pathophysiology.
British journal of pharmacology 2011;163(3):469-83.
2011: Karoly Acsai; Gudrun Antoons; Leonid Livshitz; Yoram Rudy; Karin R Sipido
Microdomain [Ca²⁺] near ryanodine receptors as reported by L-type Ca²⁺ and Na+/Ca²⁺ exchange currents.
The Journal of physiology 2011;589(Pt 10):2569-83.
2010: Gudrun Antoons; Morten B Thomsen
Repolarization variability and early afterdepolarizations in long QT syndrome type 2: is labile calcium the common denominator?
Heart rhythm : the official journal of the Heart Rhythm Society 2010;7(11):1695-6.
2010: Avram Oros; M J Houtman; P Neco; Ana Gomez; S Rajamani; P Oosterhoff; N J Attevelt; Jet D M Beekman; Michiel van der Heyden; L Ver Donck; L Belardinelli; S Richard; Gudrun Antoons; Marc A Vos
Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
British journal of pharmacology 2010;161(1):162-75.
2010: T P de Boer; L Nalos; A Stary; B Kok; M J C Houtman; Gudrun Antoons; T A B van Veen; Jet D M Beekman; B L de Groot; T Opthof; M B Rook; Marc A Vos; Michiel van der Heyden
The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
British journal of pharmacology 2010;159(7):1532-41.
2010: Gudrun Antoons; Avram Oros; Jet D M Beekman; Markus A Engelen; Marien J C Houtman; Luiz Belardinelli; Milan Stengl; Marc A Vos
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.
Journal of the American College of Cardiology 2010;55(8):801-9.
2009: Gudrun Antoons; Karin R Sipido
Dofetilide as activator of Na/Ca exchange: new perspectives on an 'old' drug. Editorial to: "Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange" by Xuan-Ping Zhang et al.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2009;23(3):189-92.
2008: Gudrun Antoons; Karin R Sipido
Targeting calcium handling in arrhythmias.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2008;10(12):1364-9.
2008: Mera Stein; Maartje Noorman; Toon A B van Veen; Eva Herold; Markus A Engelen; Mohamed Boulaksil; Gudrun Antoons; John A Jansen; Matthijs F M van Oosterhout; Richard N W Hauer; Jacques M T de Bakker; Harold V M van Rijen
Dominant arrhythmia vulnerability of the right ventricle in senescent mice.
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(3):438-48.
2008: Virginie Bito; Frank R Heinzel; Liesbeth Biesmans; Gudrun Antoons; Karin R Sipido
Crosstalk between L-type Ca2+ channels and the sarcoplasmic reticulum: alterations during cardiac remodelling.
Cardiovascular research 2008;77(2):315-24.
2007: Gudrun Antoons; Avram Oros; Virginie Bito; Karin R Sipido; Marc A Vos
Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment.
Journal of electrocardiology 2007;40(6 Suppl):S8-14.
2007: Karin R Sipido; Virginie Bito; Gudrun Antoons; Paul G A Volders; Marc A Vos
Na/Ca exchange and cardiac ventricular arrhythmias.
Annals of the New York Academy of Sciences 2007;1099():339-48.
2007: Gudrun Antoons; Paul G A Volders; Tania Stankovicova; Virginie Bito; Milan Stengl; Marc A Vos; Karin R Sipido
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.
The Journal of physiology 2007;579(Pt 1):147-60.
2006: Milan Stengl; Christian Ramakers; Dirk W Donker; Ashish Nabar; Andrew V Rybin; Roel L H M G Spätjens; Theo Van Der Nagel; Will K W H Wodzig; Karin R Sipido; Gudrun Antoons; Antoon F M Moorman; Marc A Vos; Paul G A Volders
Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on IKs downregulation and blunted beta-adrenergic activation.
Cardiovascular research 2006;72(1):90-100.
2006: Gudrun Antoons; Peter Vangheluwe; Paul G A Volders; Virginie Bito; Patricia Holemans; Marcello Ceci; Frank Wuytack; Pico Caroni; Kanigula Mubagwa; Karin R Sipido
Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.
Journal of molecular and cellular cardiology 2006;40(3):350-60.
2003: Gudrun Antoons; Mark Ver Heyen; Luc Raeymaekers; Peter Vangheluwe; Frank Wuytack; Karin R Sipido
Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only.
Circulation research 2003;92(8):881-7.
2002: Frank R Heinzel; Virginie Bito; Paul G A Volders; Gudrun Antoons; Kanigula Mubagwa; Karin R Sipido
Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes.
Circulation research 2002;91(11):1023-30.
2002: Gudrun Antoons; Kanigula Mubagwa; Ines Nevelsteen; Karin R Sipido
Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes.
The Journal of physiology 2002;543(Pt 3):889-98.
2001: Mark Ver Heyen; Stephane Heymans; Gudrun Antoons; T Reed; Muthu Periasamy; Bonaventure L Awede; Jean Lebacq; Peter Vangheluwe; Mieke Dewerchin; Désiré Collen; Karin R Sipido; Peter Carmeliet; Frank Wuytack
Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.
Circulation research 2001;89(9):838-46.