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Kohtaro Fujihashi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

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Nagatake Takahiro; Fukuyama Satoshi; Kim Dong-Young; Goda Kaoru; Igarashi Osamu; Sato Shintaro; Nochi Tomonori; Sagara Hiroshi; Yokota Yoshifumi; Jetten Anton M; Kaisho Tsuneyasu; Akira Shizuo; Mimuro Hitomi; Sasakawa Chihiro; Fukui Yoshinori; Fujihashi Kohtaro; Akiyama Taishin; Inoue Jun-ichiro; Penninger Josef M; Kunisawa Jun; Kiyono Hiroshi
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
Yuki Yoshikazu; Tokuhara Daisuke; Nochi Tomonori; Yasuda Hiroshi; Mejima Mio; Kurokawa Shiho; Takahashi Yuko; Kataoka Nobuhiro; Nakanishi Ushio; Hagiwara Yukari; Fujihashi Kohtaro; Takaiwa Fumio; Kiyono Hiroshi
Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity.
Kataoka Kosuke; Fujihashi Kohtaro
Dendritic cell-targeting DNA-based mucosal adjuvants for the development of mucosal vaccines.

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All Publications

2009: Nagatake Takahiro; Fukuyama Satoshi; Kim Dong-Young; Goda Kaoru; Igarashi Osamu; Sato Shintaro; Nochi Tomonori; Sagara Hiroshi; Yokota Yoshifumi; Jetten Anton M; Kaisho Tsuneyasu; Akira Shizuo; Mimuro Hitomi; Sasakawa Chihiro; Fukui Yoshinori; Fujihashi Kohtaro; Akiyama Taishin; Inoue Jun-ichiro; Penninger Josef M; Kunisawa Jun; Kiyono Hiroshi
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The Journal of experimental medicine 2009;206(11):2351-64.
2009: Yuki Yoshikazu; Tokuhara Daisuke; Nochi Tomonori; Yasuda Hiroshi; Mejima Mio; Kurokawa Shiho; Takahashi Yuko; Kataoka Nobuhiro; Nakanishi Ushio; Hagiwara Yukari; Fujihashi Kohtaro; Takaiwa Fumio; Kiyono Hiroshi
Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity.
Vaccine 2009;27(43):5982-8.
2009: Kataoka Kosuke; Fujihashi Kohtaro
Dendritic cell-targeting DNA-based mucosal adjuvants for the development of mucosal vaccines.
Expert review of vaccines 2009;8(9):1183-93.
2009: Fujihashi Kohtaro; Kiyono Hiroshi
Mucosal immunosenescence: new developments and vaccines to control infectious diseases.
Trends in immunology 2009;30(7):334-43.
2009: Yoshino Naoto; Fujihashi Kohtaro; Hagiwara Yukari; Kanno Hiroyuki; Takahashi Kiyomi; Kobayashi Ryoki; Inaba Noriyuki; Noda Masatoshi; Sato Shigehiro
Co-administration of cholera toxin and apple polyphenol extract as a novel and safe mucosal adjuvant strategy.
Vaccine 2009;27(35):4808-17.
2008: Schelonka Robert L; Zemlin Michael; Kobayashi Ryoki; Ippolito Gregory C; Zhuang Yingxin; Gartland G Larry; Szalai Alex; Fujihashi Kohtaro; Rajewsky Klaus; Schroeder Harry W
Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8409-15.
2008: Fukuiwa Tatsuya; Sekine Shinichi; Kobayashi Ryoki; Suzuki Hideaki; Kataoka Kosuke; Gilbert Rebekah S; Kurono Yuichi; Boyaka Prosper N; Krieg Arthur M; McGhee Jerry R; Fujihashi Kohtaro
A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity.
Vaccine 2008;26(37):4849-59.
2008: Suzuki Hideaki; Sekine Shinichi; Kataoka Kosuke; Pascual David W; Maddaloni Massimo; Kobayashi Ryoki; Fujihashi Keiko; Kozono Haruo; McGhee Jerry R; Fujihashi Kohtaro
Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells.
Gastroenterology 2008;135(3):917-25.
2008: Sekine Shinichi; Kataoka Kosuke; Fukuyama Yoshiko; Adachi Yasuo; Davydova Julia; Yamamoto Masato; Kobayashi Ryoki; Fujihashi Keiko; Suzuki Hideaki; Curiel David T; Shizukuishi Satoshi; McGhee Jerry R; Fujihashi Kohtaro
A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8126-34.
2008: Rynda Agnieszka; Maddaloni Massimo; Mierzejewska Dagmara; Ochoa-Repáraz Javier; Maslanka Tomasz; Crist Kathryn; Riccardi Carol; Barszczewska Beata; Fujihashi Kohtaro; McGhee Jerry R; Pascual David W
Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5187-200.
2007: Asanuma Hideki; Fujihashi Kohtaro; Miyakoshi Takashi; Yoshikawa Tomoki; Fujita-Yamaguchi Yoko; Kojima Naoya; Nakata Munehiro; Suzuki Yujiro; Tamura Shin-Ichi; Kurata Takeshi; Sata Tetsutaro
Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccine.
Vaccine 2007;25(39-40):6975-80.
2007: Youn Hyun-Jun; Ko Sung-Youl; Lee Kyoo-A; Ko Hyun-Jeong; Lee Yoon-Sook; Fujihashi Kohtaro; Boyaka Prosper N; Kim Sang-Hee; Horimoto Taisuke; Kweon Mi-Na; Kang Chang-Yuil
A single intranasal immunization with inactivated influenza virus and alpha-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system.
Vaccine 2007;25(28):5189-98.
2007: Kataoka Kosuke; Fujihashi Keiko; Sekine Shinichi; Fukuiwa Tatsuya; Kobayashi Ryoki; Suzuki Hideaki; Nagata Hideki; Takatsu Kiyoshi; Shizukuishi Satoshi; McGhee Jerry R; Fujihashi Kohtaro
Nasal cholera toxin elicits IL-5 and IL-5 receptor alpha-chain expressing B-1a B cells for innate mucosal IgA antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6058-65.
2007: Kataoka Kosuke; Fujihashi Keiko; Sekine Shinichi; Fukuiwa Tatsuya; Kobayashi Ryoki; Suzuki Hideaki; Nagata Hideki; Takatsu Kiyoshi; Shizukuishi Satoshi; McGhee Jerry R; Fujihashi Kohtaro
Nasal cholera toxin elicits IL-5 and IL-5 receptor alpha-chain expressing B-1a B cells for innate mucosal IgA antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6058-65.
2007: Fujihashi Kohtaro; Staats Herman F; Kozaki Shunji; Pascual David W
Mucosal vaccine development for botulinum intoxication.
Expert review of vaccines 2007;6(1):35-45.
2007: Kim Hong-Duck; Tahara Kazuki; Maxwell J Adam; Lalonde Robert; Fukuiwa Tatsuya; Fujihashi Kohtaro; Van Kampen Kent R; Kong Fan-Kun; Tang De-chu C; Fukuchi Ken-ichiro
Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease.
The journal of gene medicine 2007;9(2):88-98.
2006: Dohi Taeko; Fujihashi Kohtaro
Type 1 and 2 T helper cell-mediated colitis.
Current opinion in gastroenterology 2006;22(6):651-7.
2006: Maddaloni Massimo; Staats Herman F; Mierzejewska Dagmara; Hoyt Teri; Robinson Amy; Callis Gayle; Kozaki Shunji; Kiyono Hiroshi; McGhee Jerry R; Fujihashi Kohtaro; Pascual David W
Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5524-32.
2006: Hagiwara Yukari; Kawamura Yuki I; Kataoka Kosuke; Rahima Bibi; Jackson Raymond J; Komase Katsuhiro; Dohi Taeko; Boyaka Prosper N; Takeda Yoshifumi; Kiyono Hiroshi; McGhee Jerry R; Fujihashi Kohtaro
A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3045-54.
2006: Ippolito Gregory C; Schelonka Robert L; Zemlin Michael; Ivanov Ivaylo I; Kobayashi Ryoki; Zemlin Cosima; Gartland G Larry; Nitschke Lars; Pelkonen Jukka; Fujihashi Kohtaro; Rajewsky Klaus; Schroeder Harry W
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production.
The Journal of experimental medicine 2006;203(6):1567-78.
2006: Duverger Alexandra; Jackson Raymond J; van Ginkel Frederick W; Fischer Romy; Tafaro Angela; Leppla Stephen H; Fujihashi Kohtaro; Kiyono Hiroshi; McGhee Jerry R; Boyaka Prosper N
Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1776-83.
2005: van Ginkel Frederik W; Jackson Raymond J; Yoshino Naoto; Hagiwara Yukari; Metzger Daniel J; Connell Terry D; Vu Hong L; Martin Michael; Fujihashi Kohtaro; McGhee Jerry R
Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract.
Infection and immunity 2005;73(10):6892-902.
2005: Hino Ayako; Fukuyama Satoshi; Kataoka Kosuke; Kweon Mi-Na; Fujihashi Kohtaro; Kiyono Hiroshi
Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7423-32.
2005: Kobayashi Ryoki; Kohda Tomoko; Kataoka Kosuke; Ihara Hideshi; Kozaki Shunji; Pascual David W; Staats Herman F; Kiyono Hiroshi; McGhee Jerry R; Fujihashi Kohtaro
A novel neurotoxoid vaccine prevents mucosal botulism.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):2190-5.
2004: Fujihashi Kohtaro; McGhee Jerry R
Mucosal immunity and tolerance in the elderly.
Mechanisms of ageing and development 2004;125(12):889-98.
2004: Yoshino Naoto; Lü Fabien X-S; Fujihashi Kohtaro; Hagiwara Yukari; Kataoka Kosuke; Lu Ding; Hirst Linda; Honda Mitsuo; van Ginkel Frederik W; Takeda Yoshifumi; Miller Christopher J; Kiyono Hiroshi; McGhee Jerry R
A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6850-7.
2004: Dohi Taeko; Fujihashi Kohtaro; Koga Toshiya; Etani Yuri; Yoshino Naoto; Kawamura Yuki I; McGhee Jerry R
CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis.
The American journal of pathology 2004;165(4):1257-68.
2004: Yamamoto Masafumi; Kweon Mi-Na; Rennert Paul D; Hiroi Takachika; Fujihashi Kohtaro; McGhee Jerry R; Kiyono Hiroshi
Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(2):762-9.
2004: Hino Ayako; Kweon Mi-Na; Fujihashi Kohtaro; McGhee Jerry R; Kiyono Hiroshi
Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea.
The American journal of pathology 2004;164(4):1327-35.
2004: Kataoka Kosuke; McGhee Jerry R; Kobayashi Ryoki; Fujihashi Keiko; Shizukuishi Satoshi; Fujihashi Kohtaro
Nasal Flt3 ligand cDNA elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3612-9.
2004: Kataoka Kosuke; McGhee Jerry R; Kobayashi Ryoki; Fujihashi Keiko; Shizukuishi Satoshi; Fujihashi Kohtaro
Nasal Flt3 ligand cDNA elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3612-9.
2003: Kawamura Yuki I; Kawashima Rei; Shirai Yuko; Kato Rie; Hamabata Takashi; Yamamoto Masafumi; Furukawa Koichi; Fujihashi Kohtaro; McGhee Jerry R; Hayashi Hideo; Dohi Taeko
Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-kappaB translocation.
European journal of immunology 2003;33(11):3205-12.
2003: Boyaka Prosper N; Tafaro Angela; Fischer Romy; Leppla Stephen H; Fujihashi Kohtaro; McGhee Jerry R
Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5636-43.
2003: Dohi Taeko; Fujihashi Kohtaro; Koga Toshiya; Shirai Yuko; Kawamura Yuki I; Ejima Chieko; Kato Rie; Saitoh Kiyoshi; McGhee Jerry R
T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice.
Gastroenterology 2003;124(3):672-82.
2003: Kato Hirotomo; Fujihashi Kohtaro; Kato Rie; Dohi Taeko; Fujihashi Keiko; Hagiwara Yukari; Kataoka Kosuke; Kobayashi Ryoki; McGhee Jerry R
Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions.
International immunology 2003;15(2):145-58.
2003: Kato Hirotomo; Fujihashi Kohtaro; Kato Rie; Dohi Taeko; Fujihashi Keiko; Hagiwara Yukari; Kataoka Kosuke; Kobayashi Ryoki; McGhee Jerry R
Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions.
International immunology 2003;15(2):145-58.
2003: Hagiwara Yukari; McGhee Jerry R; Fujihashi Keiko; Kobayashi Ryoki; Yoshino Naoto; Kataoka Kosuke; Etani Yuri; Kweon Mi-Na; Tamura Shinichi; Kurata Takeshi; Takeda Yoshifumi; Kiyono Hiroshi; Fujihashi Kohtaro
Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1754-62.
2003: Hagiwara Yukari; McGhee Jerry R; Fujihashi Keiko; Kobayashi Ryoki; Yoshino Naoto; Kataoka Kosuke; Etani Yuri; Kweon Mi-Na; Tamura Shinichi; Kurata Takeshi; Takeda Yoshifumi; Kiyono Hiroshi; Fujihashi Kohtaro
Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1754-62.
2003: Boyaka Prosper N; Ohmura Mari; Fujihashi Kohtaro; Koga Toshiya; Yamamoto Masafumi; Kweon Mi-Na; Takeda Yoshifumi; Jackson Raymond J; Kiyono Hiroshi; Yuki Yoshikazu; McGhee Jerry R
Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):454-62.
2003: Boyaka Prosper N; Tafaro Angela; Fischer Romy; Fujihashi Kohtaro; Jirillo Emilio; McGhee Jerry R
Therapeutic manipulation of the immune system: enhancement of innate and adaptive mucosal immunity.
Current pharmaceutical design 2003;9(24):1965-72.
2002: Kweon Mi-Na; Yamamoto Masafumi; Watanabe Fumiko; Tamura Shinichi; Van Ginkel Frederik W; Miyauchi Akira; Takagi Hiroaki; Takeda Yoshifumi; Hamabata Takashi; Fujihashi Kohtaro; McGhee Jerry R; Kiyono Hiroshi
A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies.
The Journal of infectious diseases 2002;186(9):1261-9.
2002: Fujihashi Kohtaro; Koga Toshiya; van Ginkel Frederik W; Hagiwara Yukari; McGhee Jerry R
A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants.
Vaccine 2002;20(19-20):2431-8.
2001: Fujihashi K; Kato H; van Ginkel F W; Koga T; Boyaka P N; Jackson R J; Kato R; Hagiwara Y; Etani Y; Goma I; Fujihashi K; Kiyono H; McGhee J R
A revisit of mucosal IgA immunity and oral tolerance.
Acta odontologica Scandinavica 2001;59(5):301-8.
2001: Fujihashi K; Kato H; van Ginkel F W; Koga T; Boyaka P N; Jackson R J; Kato R; Hagiwara Y; Etani Y; Goma I; Fujihashi K; Kiyono H; McGhee J R
A revisit of mucosal IgA immunity and oral tolerance.
Acta odontologica Scandinavica 2001;59(5):301-8.
2001: Dohi T; Rennert P D; Fujihashi K; Kiyono H; Shirai Y; Kawamura Y I; Browning J L; McGhee J R
Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2781-90.
2001: Yuki Y; Byun Y; Fujita M; Izutani W; Suzuki T; Udaka S; Fujihashi K; McGhee J R; Kiyono H
Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis.
Biotechnology and bioengineering 2001;74(1):62-9.
2001: Fujihashi K; Dohi T; Rennert P D; Yamamoto M; Koga T; Kiyono H; McGhee J R
Peyer's patches are required for oral tolerance to proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3310-5.
2001: Kato H; Fujihashi K; Kato R; Yuki Y; McGhee J R
Oral tolerance revisited: prior oral tolerization abrogates cholera toxin-induced mucosal IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3114-21.
2001: Byun Y; Ohmura M; Fujihashi K; Yamamoto S; McGhee J R; Udaka S; Kiyono H; Takeda Y; Kohsaka T; Yuki Y
Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies.
Vaccine 2001;19(15-16):2061-70.
2001: Kato H; Kato R; Fujihashi K; McGhee J R
Role of mucosal antibodies in viral infections.
Current topics in microbiology and immunology 2001;260():201-28.
2000: Boyaka P N; Wright P F; Marinaro M; Kiyono H; Johnson J E; Gonzales R A; Ikizler M R; Werkhaven J A; Jackson R J; Fujihashi K; Di Fabio S; Staats H F; McGhee J R
Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils.
The American journal of pathology 2000;157(6):2023-35.
2000: Koga T; McGhee J R; Kato H; Kato R; Kiyono H; Fujihashi K
Evidence for early aging in the mucosal immune system.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5352-9.
2000: Dohi T; Fujihashi K; Kiyono H; Elson C O; McGhee J R
Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis.
Gastroenterology 2000;119(3):724-33.
2000: Yamamoto M; Kiyono H; Kweon M N; Yamamoto S; Fujihashi K; Kurazono H; Imaoka K; Bluethmann H; Takahashi I; Takeda Y; Azuma M; McGhee J R
Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses.
The Journal of infectious diseases 2000;182(1):180-90.
2000: Yamamoto M; Rennert P; McGhee J R; Kweon M N; Yamamoto S; Dohi T; Otake S; Bluethmann H; Fujihashi K; Kiyono H
Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5184-91.
2000: Fujihashi K; Koga T; McGhee J R
Mucosal vaccination and immune responses in the elderly.
Vaccine 2000;18(16):1675-80.
1999: Fujihashi K; Dohi T; Kweon M N; McGhee J R; Koga T; Cooper M D; Tonegawa S; Kiyono H
gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion.
International immunology 1999;11(12):1907-16.
1999: Pascual D W; Hone D M; Hall S; van Ginkel F W; Yamamoto M; Walters N; Fujihashi K; Powell R J; Wu S; Vancott J L; Kiyono H; McGhee J R
Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response.
Infection and immunity 1999;67(12):6249-56.
1999: van Ginkel F W; Wahl S M; Kearney J F; Kweon M N; Fujihashi K; Burrows P D; Kiyono H; McGhee J R
Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1951-7.
1999: McGhee J R; Kiyono H; Kubota M; Kawabata S; Miller C J; Lehner T; Imaoka K; Fujihashi K
Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques.
The Journal of infectious diseases 1999;179 Suppl 3():S480-4.
1999: Boyaka P N; Marinaro M; Vancott J L; Takahashi I; Fujihashi K; Yamamoto M; van Ginkel F W; Jackson R J; Kiyono H; McGhee J R
Strategies for mucosal vaccine development.
The American journal of tropical medicine and hygiene 1999;60(4 Suppl):35-45.
1999: Dohi T; Fujihashi K; Rennert P D; Iwatani K; Kiyono H; McGhee J R
Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses.
The Journal of experimental medicine 1999;189(8):1169-80.
1999: Kweon M N; Fujihashi K; Wakatsuki Y; Koga T; Yamamoto M; McGhee J R; Kiyono H
Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):1904-9.
1998: Imaoka K; Miller C J; Kubota M; McChesney M B; Lohman B; Yamamoto M; Fujihashi K; Someya K; Honda M; McGhee J R; Kiyono H
Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5952-8.
1998: Kawabata S; Boyaka P N; Coste M; Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics.
Gastroenterology 1998;115(4):866-73.
1998: Yuki Y; Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
Human milk proteins including secretory IgA fail to elicit tolerance after feeding.
International immunology 1998;10(4):537-45.
1998: Yamamoto M; Fujihashi K; Kawabata K; McGhee J R; Kiyono H
A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2188-96.
1998: Kweon M N; Fujihashi K; VanCott J L; Higuchi K; Yamamoto M; McGhee J R; Kiyono H
Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1687-93.
1998: Kawabata S; Miller C J; Lehner T; Fujihashi K; Kubota M; McGhee J R; Imaoka K; Hiroi T; Kiyono H
Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques.
The Journal of infectious diseases 1998;177(1):26-33.
1997: Kawabata S; Boyaka P N; Coste M; Fujihashi K; Hamada S; McGhee J R; Kiyono H
A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine.
Biochemical and biophysical research communications 1997;241(3):797-802.
1997: Fujihashi K; McGhee J R; Yamamoto M; Peschon J J; Kiyono H
An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state.
European journal of immunology 1997;27(9):2133-8.
1997: Kubota M; Miller C J; Imaoka K; Kawabata S; Fujihashi K; McGhee J R; Kiyono H
Oral immunization with simian immunodeficiency virus p55gag and cholera toxin elicits both mucosal IgA and systemic IgG immune responses in nonhuman primates.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5321-9.
1997: Yamamoto S; Kiyono H; Yamamoto M; Imaoka K; Fujihashi K; Van Ginkel F W; Noda M; Takeda Y; McGhee J R
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5267-72.
1997: Yamamoto S; Takeda Y; Yamamoto M; Kurazono H; Imaoka K; Yamamoto M; Fujihashi K; Noda M; Kiyono H; McGhee J R
Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity.
The Journal of experimental medicine 1997;185(7):1203-10.
1997: Vancott J L; Kweon M; Fujihashi K; Yamamoto M; Marinaro M; Kiyono H; McGhee J R
Helper T subsets and cytokines for mucosal immunity and tolerance.
Behring Institute Mitteilungen 1997;(98):44-52.
1997: Wallace M; Scharko A M; Pauza C D; Fisch P; Imaoka K; Kawabata S; Fujihashi K; Kiyono H; Tanaka Y; Bloom B R; Malkovsky M
Functional gamma delta T-lymphocyte defect associated with human immunodeficiency virus infections.
Molecular medicine (Cambridge, Mass.) 1997;3(1):60-71.
1997: Yamamoto M; Fujihashi K; Hiroi T; McGhee J R; Van Dyke T E; Kiyono H
Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation.
Journal of periodontal research 1997;32(1 Pt 2):115-9.
1997: Fujihashi K; Kweon M N; Kiyono H; VanCott J L; van Ginkel F W; Yamamoto M; McGhee J R
A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity.
Springer seminars in immunopathology 1997;18(4):477-94.
1996: Elson C O; Beagley K W; Sharmanov A T; Fujihashi K; Kiyono H; Tennyson G S; Cong Y; Black C A; Ridwan B W; McGhee J R
Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2174-85.
1996: Fujihashi K; McGhee J R; Kweon M N; Cooper M D; Tonegawa S; Takahashi I; Hiroi T; Mestecky J; Kiyono H
gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.
The Journal of experimental medicine 1996;183(4):1929-35.
1996: Fujihashi K; Kawabata S; Hiroi T; Yamamoto M; McGhee J R; Nishikawa S; Kiyono H
Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3613-8.
1996: Jackson R J; Fujihashi K; Kiyono H; McGhee J R
Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses.
Journal of immunological methods 1996;190(2):189-97.
1996: Takahashi I; Kiyono H; Jackson R J; Fujihashi K; Staats H F; Hamada S; Clements J D; Bost K L; McGhee J R
Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine.
Infection and immunity 1996;64(4):1290-8.
1996: Takahashi I; Marinaro M; Kiyono H; Jackson R J; Nakagawa I; Fujihashi K; Hamada S; Clements J D; Bost K L; McGhee J R
Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin.
The Journal of infectious diseases 1996;173(3):627-35.
1996: Fujihashi K; Yamamoto M; Hiroi T; Bamberg T V; McGhee J R; Kiyono H
Selected Th1 and Th2 cytokine mRNA expression by CD4(+) T cells isolated from inflamed human gingival tissues.
Clinical and experimental immunology 1996;103(3):422-8.
1996: Yamamoto M; Vancott J L; Okahashi N; Marinaro M; Kiyono H; Fujihashi K; Jackson R J; Chatfield S N; Bluethmann H; McGhee J R
The role of Th1 and Th2 cells for mucosal IgA responses.
Annals of the New York Academy of Sciences 1996;778():64-71.
1996: Fujihashi K; McGhee J R; Yamamoto M; Hiroi T; Kiyono H
Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance.
Annals of the New York Academy of Sciences 1996;778():55-63.
1996: Jackson R J; Marinaro M; VanCott J L; Yamamoto M; Okahashi N; Fujihashi K; Kiyono H; Chatfield S N; McGhee J R
Mucosal immunity: regulation by helper T cells and a novel method for detection.
Journal of biotechnology 1996;44(1-3):209-16.
1996: Yamamoto M; Kawabata K; Fujihashi K; McGhee J R; Van Dyke T E; Bamberg T V; Hiroi T; Kiyono H
Absence of exogenous interleukin-4-induced apoptosis of gingival macrophages may contribute to chronic inflammation in periodontal diseases.
The American journal of pathology 1996;148(1):331-9.
1995: Marinaro M; Staats H F; Hiroi T; Jackson R J; Coste M; Boyaka P N; Okahashi N; Yamamoto M; Kiyono H; Bluethmann H; Fujihashi K; McGhee J R
Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4621-9.
1995: Hiroi T; Fujihashi K; McGhee J R; Kiyono H
Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells.
European journal of immunology 1995;25(10):2743-51.
1995: Beagley K W; Fujihashi K; Lagoo A S; Lagoo-Deenadaylan S; Black C A; Murray A M; Sharmanov A T; Yamamoto M; McGhee J R; Elson C O
Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):5611-9.
1995: Aicher W K; Eibel H; Fujihashi K; Boehm T; Beagley K W; McGhee J R; Kiyono H
Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes.
Advances in experimental medicine and biology 1995;371A():125-8.
1994: Hiroi T; Fujihashi K; McGhee J R; Kiyono H
Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues.
European journal of immunology 1994;24(11):2653-8.
1994: Xu-Amano J; Jackson R J; Fujihashi K; Kiyono H; Staats H F; McGhee J R
Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin.
Vaccine 1994;12(10):903-11.
1994: Yamamoto M; Fujihashi K; Amano M; McGhee J R; Beagley K W; Kiyono H
Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation.
European journal of immunology 1994;24(6):1301-6.
1994: Di Fabio S; Mbawuike I N; Kiyono H; Fujihashi K; Couch R B; McGhee J R
Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells.
International immunology 1994;6(1):11-9.
1994: Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
Function of alpha beta TCR+ and gamma delta TCR+ IELs for the gastrointestinal immune response.
International reviews of immunology 1994;11(1):1-14.
1994: McGhee J R; Xu-Amano J; Miller C J; Jackson R J; Fujihashi K; Staats H F; Kiyono H
The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.
Reproduction, fertility, and development 1994;6(3):369-79.
1993: Fujihashi K; Yamamoto M; McGhee J R; Kiyono H
alpha beta T cell receptor-positive intraepithelial lymphocytes with CD4+, CD8- and CD4+, CD8+ phenotypes from orally immunized mice provide Th2-like function for B cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6681-91.
1993: Fujihashi K; Yamamoto M; McGhee J R; Beagley K W; Kiyono H
Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity.
International immunology 1993;5(11):1473-81.
1993: Jackson R J; Fujihashi K; Xu-Amano J; Kiyono H; Elson C O; McGhee J R
Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant.
Infection and immunity 1993;61(10):4272-9.
1993: Kang D W; Ohkawa S; Difabio S; Merrill K W; Fujihashi K; Yamamoto M; Miller C J; Marthas M; McGhee J R; Eldridge J H
Characterization of T and B cells isolated from mucosa-associated tissues of the rhesus macaque.
Cellular immunology 1993;151(2):379-91.
1993: Xu-Amano J; Kiyono H; Jackson R J; Staats H F; Fujihashi K; Burrows P D; Elson C O; Pillai S; McGhee J R
Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.
The Journal of experimental medicine 1993;178(4):1309-20.
1993: McGhee J R; Fujihashi K; Xu-Amano J; Jackson R J; Elson C O; Beagley K W; Kiyono H
New perspectives in mucosal immunity with emphasis on vaccine development.
Seminars in hematology 1993;30(4 Suppl 4):3-12; discussion 13-5.
1993: Beagley K W; Fujihashi K; Black C A; Lagoo A S; Yamamoto M; McGhee J R; Kiyono H
The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes.
European journal of immunology 1993;23(8):2049-52.
1993: Fujihashi K; Kono Y; Beagley K W; Yamamoto M; McGhee J R; Mestecky J; Kiyono H
Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.
Journal of periodontology 1993;64(5 Suppl):400-6.
1993: Fujihashi K; Beagley K W; Kono Y; Aicher W K; Yamamoto M; DiFabio S; Xu-Amano J; McGhee J R; Kiyono H
Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.
The American journal of pathology 1993;142(4):1239-50.
1993: Fujihashi K; McGhee J R; Beagley K W; McPherson D T; McPherson S A; Huang C M; Kiyono H
Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells.
Journal of immunological methods 1993;160(2):181-9.
1993: Yamamoto M; Fujihashi K; Beagley K W; McGhee J R; Kiyono H
Cytokine synthesis by intestinal intraepithelial lymphocytes. Both gamma/delta T cell receptor-positive and alpha/beta T cell receptor-positive T cells in the G1 phase of cell cycle produce IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):106-14.
1992: Fujihashi K; Kono Y; Kiyono H
Effects of IL6 on B cells in mucosal immune response and inflammation.
Research in immunology 1992;143(7):744-9.
1992: Aicher W K; Fujihashi K; Yamamoto M; Kiyono H; Pitts A M; McGhee J R
Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site.
International immunology 1992;4(9):959-68.
1992: Fujihashi K; Taguchi T; Aicher W K; McGhee J R; Bluestone J A; Eldridge J H; Kiyono H
Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.
The Journal of experimental medicine 1992;175(3):695-707.
1992: Lue C; Kiyono H; Fujihashi K; McGhee J R; Mestecky J
The use of the hu-PBL-SCID mouse model to study lymphocyte homing and responsiveness to recall antigens.
Regional immunology 1992;4(2):86-90.
1992: Mega J; Fujihashi K; Kiyono H
Regulation of mucosal immune responses by T lymphocytes: the effect of chronic CD4+ T cell deficiency on IgA synthesis.
Regional immunology 1992;4(2):70-8.
1992: Aicher W K; Fujihashi K; Taguchi T; McGhee J R; Yamamoto M; Eldridge J H; Gay S; Kiyono H
Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities.
European journal of immunology 1992;22(1):137-45.
1992: Mega J; Fujihashi K; Yamamoto M; McGhee J R; Hirasawa M; Kiyono H
Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response.
Advances in experimental medicine and biology 1992;327():119-31.
1992: Xu-Amano J; Beagley K W; Mega J; Fujihashi K; Kiyono H; McGhee J R
Induction of T helper cells and cytokines for mucosal IgA responses.
Advances in experimental medicine and biology 1992;327():107-17.
1991: Taguchi T; Aicher W K; Fujihashi K; Yamamoto M; McGhee J R; Bluestone J A; Kiyono H
Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3736-44.
1991: Fujihashi K; McGhee J R; Lue C; Beagley K W; Taga T; Hirano T; Kishimoto T; Mestecky J; Kiyono H
Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.
The Journal of clinical investigation 1991;88(1):248-52.
1991: Kono Y; Beagley K W; Fujihashi K; McGhee J R; Taga T; Hirano T; Kishimoto T; Kiyono H
Cytokine regulation of localized inflammation. Induction of activated B cells and IL-6-mediated polyclonal IgG and IgA synthesis in inflamed human gingiva.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1812-21.
1991: Lue C; Kiyono H; McGhee J R; Fujihashi K; Kishimoto T; Hirano T; Mestecky J
Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells.
Cellular immunology 1991;132(2):423-32.
1991: McGhee J R; Fujihashi K; Beagley K W; Kiyono H
Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses.
Immunologic research 1991;10(3-4):418-22.
1991: Kiyono H; Fujihashi K; Taguchi T; Aicher W K; McGhee J R
Regulatory functions for murine intraepithelial lymphocytes in mucosal responses.
Immunologic research 1991;10(3-4):324-30.
1991: McGhee J R; Fujihashi K; Lue C; Beagley K W; Mestecky J; Kiyono H
Role of IL-6 in human antigen-specific and polyclonal IgA responses.
Advances in experimental medicine and biology 1991;310():113-21.
1990: Fujihashi K; Taguchi T; McGhee J R; Eldridge J H; Bruce M G; Green D R; Singh B; Kiyono H
Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(7):2010-9.
1990: Kiyono H; Taguchi T; Aicher W K; Beagley K W; Fujihashi K; Eldridge J H; McGhee J R
Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses.
International reviews of immunology 1990;6(4):263-73.
1989: Fujihashi K; Kiyono H; Aicher W K; Green D R; Singh B; Eldridge J H; McGhee J R
Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3415-22.
1989: Beagley K W; Fujihashi K; Aicher W; Xu J; Kiyono H; Eldridge J H; Bruce M G; Taguchi T; Green D R; Singh B
Mucosal homeostasis: role of interleukins, isotype-specific factors and contrasuppression in the IgA response.
Immunological investigations 1989;18(1-4):77-89.
1988: Kitamura K; Kiyono H; Fujihashi K; Eldrige J H; Beagley K W; McGhee J R
Isotype-specific immunoregulation. Systemic antigen induces splenic T contrasuppressor cells which support IgM and IgG subclass but not IgA responses.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1385-92.
1988: Fujihashi K; Kiyono H; Beagley K W; Eldridge J H; McGhee J R
Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation.
Advances in experimental medicine and biology 1988;237():649-53.
1987: Kitamura K; Kiyono H; Fujihashi K; Eldridge J H; Green D R; McGhee J R
Contrasuppressor cells that break oral tolerance are antigen-specific T cells distinct from T helper (L3T4+), T suppressor (Lyt-2+), and B cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3251-9.

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