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Hirota Fujiki

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Eung-Gook Kim; In Kyoung Lim; Junho Chung; Hirota Fujiki; Jöerg Hoheisel; Hiroyuki Seimiya; Sang Chul Park
The eleventh Korea-Japan-Germany joint symposium on cancer and ageing research.
Hirota Fujiki; Masami Suganuma
Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention.
Masami Suganuma; Atsushi Takahashi; Tatsuro Watanabe; Kensei Yamaguchi; Hirota Fujiki
Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori.

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2013: Eung-Gook Kim; In Kyoung Lim; Junho Chung; Hirota Fujiki; Jöerg Hoheisel; Hiroyuki Seimiya; Sang Chul Park
The eleventh Korea-Japan-Germany joint symposium on cancer and ageing research.
Journal of cancer research and clinical oncology 2013;139(6):901-4.
2012: Hirota Fujiki; Masami Suganuma
Green tea: an effective synergist with anticancer drugs for tertiary cancer prevention.
Cancer letters 2012;324(2):119-25.
2012: Masami Suganuma; Atsushi Takahashi; Tatsuro Watanabe; Kensei Yamaguchi; Hirota Fujiki
Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori.
Cancer letters 2012;322(2):133-8.
2012: Hirota Fujiki; Kazue Imai; Hisataka Moriwaki; Kei Nakachi; Masahito Shimizu; Masami Suganuma
Challenging the effectiveness of green tea in primary and tertiary cancer prevention.
Journal of cancer research and clinical oncology 2012;138(8):1259-70.
2011: Masami Suganuma; Achinto Saha; Hirota Fujiki
New cancer treatment strategy using combination of green tea catechins and anticancer drugs.
Cancer science 2011;102(2):317-23.
2011: Hirota Fujiki; Masami Suganuma
Tumor promoters--microcystin-LR, nodularin and TNF-α and human cancer development.
Anti-cancer agents in medicinal chemistry 2011;11(1):4-18.
2010: Achinto Saha; Takashi Kuzuhara; Noriko Echigo; Masami Suganuma; Hirota Fujiki
New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin.
Cancer prevention research (Philadelphia, Pa.) 2010;3(8):953-62.
2010: Achinto Saha; Takashi Kuzuhara; Noriko Echigo; Atsuko Fujii; Masami Suganuma; Hirota Fujiki
Apoptosis of human lung cancer cells by curcumin mediated through up-regulation of "growth arrest and DNA damage inducible genes 45 and 153".
Biological & pharmaceutical bulletin 2010;33(8):1291-9.
2010: Tatsuro Watanabe; Kazuya Hirano; Atsushi Takahashi; Kensei Yamaguchi; Masatoshi Beppu; Hirota Fujiki; Masami Suganuma
Nucleolin on the cell surface as a new molecular target for gastric cancer treatment.
Biological & pharmaceutical bulletin 2010;33(5):796-803.
2009: Hideaki Tsuge; Toshiharu Tsurumura; Hiroko Utsunomiya; Daisuke Kise; Takashi Kuzuhara; Tatsuro Watanabe; Hirota Fujiki; Masami Suganuma
Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing protein.
Biochemical and biophysical research communications 2009;388(2):193-8.
2009: Hirota Fujiki; Masami Suganuma
Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors.
Progress in molecular and subcellular biology 2009;46():221-54.
2008: Masahito Shimizu; Yasushi Fukutomi; Mitsuo Ninomiya; Kazuo Nagura; Tomohiro Kato; Hiroshi Araki; Masami Suganuma; Hirota Fujiki; Hisataka Moriwaki
Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(11):3020-5.
2008: Masami Suganuma; Kensei Yamaguchi; Yoshie Ono; Haruo Matsumoto; Tomonori Hayashi; Takahiko Ogawa; Kazue Imai; Takashi Kuzuhara; Akira Nishizono; Hirota Fujiki
TNF-alpha-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells.
International journal of cancer. Journal international du cancer 2008;123(1):117-22.
2008: Hirota Fujiki; Sang Chul Park; In Kyoung Lim; Yasuhito Yuasa
Friendship in research: the Japan-Korea Symposia on Cancer and Ageing.
Journal of cancer research and clinical oncology 2008;134(7):813-7.
2008: Takashi Kuzuhara; Daisuke Kise; Yayoi Shirakawa; Kinuko Sasada; Masami Suganuma; Hirota Fujiki
Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate.
Biological & pharmaceutical bulletin 2008;31(5):816-9.
2008: Takashi Kuzuhara; Masami Suganuma; Hirota Fujiki
Green tea catechin as a chemical chaperone in cancer prevention.
Cancer letters 2008;261(1):12-20.
2007: Takashi Kuzuhara; Masami Suganuma; K Oka; Hirota Fujiki
DNA-binding activity of TNF-alpha inducing protein from Helicobacter pylori.
Biochemical and biophysical research communications 2007;362(4):805-10.
2007: Takashi Kuzuhara; Akitoshi Tanabe; Yoshihisa Sei; Kentaro Yamaguchi; Masami Suganuma; Hirota Fujiki
Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins.
Molecular carcinogenesis 2007;46(8):640-5.
2007: Takashi Kuzuhara; Masami Suganuma; Miki Kurusu; Hirota Fujiki
Helicobacter pylori-secreting protein Tipalpha is a potent inducer of chemokine gene expressions in stomach cancer cells.
Journal of cancer research and clinical oncology 2007;133(5):287-96.
2006: Masami Suganuma; Miki Kurusu; Kaori Suzuki; Emi Tasaki; Hirota Fujiki
Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene.
International journal of cancer. Journal international du cancer 2006;119(1):33-40.
2006: Takashi Kuzuhara; Yoshihisa Sei; Kentaro Yamaguchi; Masami Suganuma; Hirota Fujiki
DNA and RNA as new binding targets of green tea catechins.
The Journal of biological chemistry 2006;281(25):17446-56.
2006: S C Park; In Kyoung Lim; G Y Koh; Y-J Surh; Y S Lee; Hirota Fujiki; T Yamamoto; Y Yuasa; N Maruyama; S Goto
The seventh Korea-Japan joint symposium on cancer and ageing research: molecular targets in cancer and ageing research.
Journal of cancer research and clinical oncology 2006;132(5):339-42.
2006: Masami Suganuma; Takashi Kuzuhara; Kensei Yamaguchi; Hirota Fujiki
Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomach.
Journal of biochemistry and molecular biology 2006;39(1):1-8.
2005: Masami Suganuma; Hirota Fujiki
[Mechanisms of action of tipa (TNF-alpha inducing protein), a new carcinogenic factor, released from H. pylori].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 11():80-3.
2005: Takashi Kuzuhara; Masami Suganuma; Hideaki Tsuge; Hirota Fujiki
Presence of a motif conserved between Helicobacter pylori TNF-alpha inducing protein (Tipalpha) and penicillin-binding proteins.
Biological & pharmaceutical bulletin 2005;28(11):2133-7.
2005: Masami Suganuma; Miki Kurusu; Kaori Suzuki; Akira Nishizono; Kazunori Murakami; Toshio Fujioka; Hirota Fujiki
New tumor necrosis factor-alpha-inducing protein released from Helicobacter pylori for gastric cancer progression.
Journal of cancer research and clinical oncology 2005;131(5):305-13.
2004: Hirota Fujiki; H Takeuchi; N Nishitani; H Yamanaka; Kaori Suzuki; Miki Kurusu; Masami Suganuma
Carcinogenic potential of tobacco tar-resistant Staphylococcus aureus in buccal cavity.
Journal of cancer research and clinical oncology 2004;130(5):301-5.
2003: Hirota Fujiki; Masami Suganuma; Miki Kurusu; Sachiko Okabe; Yoko Imayoshi; Shoko Taniguchi; Takashi Yoshida
New TNF-alpha releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen.
Mutation research 2003;523-524():119-25.
2002: Hirota Fujiki; Masami Suganuma; Kazue Imai; Kei Nakachi
Green tea: cancer preventive beverage and/or drug.
Cancer letters 2002;188(1-2):9-13.
2002: Hirota Fujiki; Masami Suganuma; Sachiko Okabe; Miki Kurusu; Kazue Imai; Kei Nakachi
Involvement of TNF-alpha changes in human cancer development, prevention and palliative care.
Mechanisms of ageing and development 2002;123(12):1655-63.
2002: Nobukazu Fujimoto; Naoko Sueoka; Eisaburo Sueoka; Sachiko Okabe; Masami Suganuma; Mine Harada; Hirota Fujiki
Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1.
International journal of oncology 2002;20(6):1233-9.
2002: Masami Suganuma; Sachiko Okabe; Miki Kurusu; N Iida; S Ohshima; Y Saeki; T Kishimoto; Hirota Fujiki
Discrete roles of cytokines, TNF-alpha, IL-1, IL-6 in tumor promotion and cell transformation.
International journal of oncology 2002;20(1):131-6.
2001: Sang Chul Park; In Kyoung Lim; N S Paik; T Yamamoto; Y Yuasa; K Nakachi; Hirota Fujiki
Japan-Korea Cancer Research Symposium: investigation on the balanced cooperation of cancer cells with the human body.
Journal of cancer research and clinical oncology 2001;127(11):692-5.
2001: S Okabe; Masami Suganuma; Y Imayoshi; S Taniguchi; T Yoshida; Hirota Fujiki
New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki.
Biological & pharmaceutical bulletin 2001;24(10):1145-8.
2001: Masami Suganuma; Miki Kurusu; S Okabe; Naoko Sueoka; M Yoshida; Y Wakatsuki; Hirota Fujiki
Helicobacter pylori membrane protein 1: a new carcinogenic factor of Helicobacter pylori.
Cancer research 2001;61(17):6356-9.
2001: Hirota Fujiki; Masami Suganuma; Sachiko Okabe; Eisaburo Sueoka; Naoko Sueoka; N Fujimoto; Y Goto; S Matsuyama; K Imai; K Nakachi
Cancer prevention with green tea and monitoring by a new biomarker, hnRNP B1.
Mutation research 2001;480-481():299-304.
2001: S Okabe; N Fujimoto; Naoko Sueoka; Masami Suganuma; Hirota Fujiki
Modulation of gene expression by (-)-epigallocatechin gallate in PC-9 cells using a cDNA expression array.
Biological & pharmaceutical bulletin 2001;24(8):883-6.
2001: Naoko Sueoka; Masami Suganuma; Eisaburo Sueoka; S Okabe; S Matsuyama; K Imai; K Nakachi; Hirota Fujiki
A new function of green tea: prevention of lifestyle-related diseases.
Annals of the New York Academy of Sciences 2001;928():274-80.
2001: Eisaburo Sueoka; Naoko Sueoka; Y Goto; S Matsuyama; H Nishimura; M Sato; S Fujimura; H Chiba; Hirota Fujiki
Heterogeneous nuclear ribonucleoprotein B1 as early cancer biomarker for occult cancer of human lungs and bronchial dysplasia.
Cancer research 2001;61(5):1896-902.
2001: Masami Suganuma; Y Ohkura; S Okabe; Hirota Fujiki
Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice.
Journal of cancer research and clinical oncology 2001;127(1):69-72.
2000: In Kyoung Lim; Sang Chul Park; Hirota Fujiki
The Seoul Symposium of the Journal of Cancer Research and Clinical Oncology Regulation of aging and carcinogenesis.
Journal of cancer research and clinical oncology 2000;126(7):418-23.
2000: Masami Suganuma; Eisaburo Sueoka; Naoko Sueoka; S Okabe; Hirota Fujiki
Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression.
BioFactors (Oxford, England) 2000;13(1-4):67-72.
2000: Hirota Fujiki; Masami Suganuma; S Okabe; Eisaburo Sueoka; K Suga; K Imai; K Nakachi
A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (-)-epigallocatechin gallate and green tea--a review.
Cancer detection and prevention 2000;24(1):91-9.
1999: Y Goto; Eisaburo Sueoka; H Chiba; Hirota Fujiki
Significance of heterogeneous nuclear ribonucleoprotein B1 as a new early detection marker for oral squamous cell carcinoma.
Japanese journal of cancer research : Gann 1999;90(12):1358-63.
1999: Masami Suganuma; S Okabe; M W Marino; A Sakai; Eisaburo Sueoka; Hirota Fujiki
Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice.
Cancer research 1999;59(18):4516-8.
1999: Masami Suganuma; S Okabe; Naoko Sueoka; Eisaburo Sueoka; S Matsuyama; K Imai; K Nakachi; Hirota Fujiki
Green tea and cancer chemoprevention.
Mutation research 1999;428(1-2):339-44.
1999: S Okabe; Y Ochiai; M Aida; K Park; S J Kim; T Nomura; Masami Suganuma; Hirota Fujiki
Mechanistic aspects of green tea as a cancer preventive: effect of components on human stomach cancer cell lines.
Japanese journal of cancer research : Gann 1999;90(7):733-9.
1999: S Okabe; Masami Suganuma; Y Tada; Y Ochiai; Eisaburo Sueoka; H Kohya; A Shibata; M Takahashi; M Mizutani; T Matsuzaki; Hirota Fujiki
Disaccharide esters screened for inhibition of tumor necrosis factor-alpha release are new anti-cancer agents.
Japanese journal of cancer research : Gann 1999;90(6):669-76.
1999: Hirota Fujiki; Masami Suganuma; S Okabe; Eisaburo Sueoka; K Suga; K Imai; K Nakachi; S Kimura
Mechanistic findings of green tea as cancer preventive for humans.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1999;220(4):225-8.
1999: Eisaburo Sueoka; Y Goto; Naoko Sueoka; Y Kai; T Kozu; Hirota Fujiki
Heterogeneous nuclear ribonucleoprotein B1 as a new marker of early detection for human lung cancers.
Cancer research 1999;59(7):1404-7.
1999: Hirota Fujiki; Masami Suganuma
Unique features of the okadaic acid activity class of tumor promoters.
Journal of cancer research and clinical oncology 1999;125(3-4):150-5.
1999: A Komori; Eisaburo Sueoka; Hirota Fujiki; M Ishii; T Kozu
Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines.
Japanese journal of cancer research : Gann 1999;90(1):60-8.
1999: Masami Suganuma; S Okabe; Y Kai; Naoko Sueoka; Eisaburo Sueoka; Hirota Fujiki
Synergistic effects of (--)-epigallocatechin gallate with (--)-epicatechin, sulindac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9.
Cancer research 1999;59(1):44-7.
1998: Eisaburo Sueoka; Naoko Sueoka; Y Kai; S Okabe; Masami Suganuma; K Kanematsu; T Yamamoto; Hirota Fujiki
Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation.
Biochemical and biophysical research communications 1998;252(3):566-70.
1998: Masami Suganuma; S Okabe; M Oniyama; Y Tada; H Ito; Hirota Fujiki
Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue.
Carcinogenesis 1998;19(10):1771-6.
1998: In Kyoung Lim; Myung Soog Lee; Min Sook Ryu; Tae Jun Park; Hirota Fujiki; H Eguchi; Woon Ki Paik
Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21.
Molecular carcinogenesis 1998;23(1):25-35.
1998: Hirota Fujiki; Masami Suganuma; S Okabe; Naoko Sueoka; A Komori; Eisaburo Sueoka; T Kozu; Y Tada; K Suga; K Imai; K Nakachi
Cancer inhibition by green tea.
Mutation research 1998;402(1-2):307-10.
1998: Masami Suganuma; Hirota Fujiki
[Tumor promotion by inhibitors of protein phosphatase 1 and 2A].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(8 Suppl):1102-10.
1998: S Okabe; Naoko Sueoka; A Komori; Masami Suganuma; Y Endo; K Shudo; Hirota Fujiki
Twist form of teleocidin derivatives is active in in vivo tumor promotion by (-)-benzolactam-V8-310.
Biological & pharmaceutical bulletin 1998;21(5):465-8.
1998: Naoko Sueoka; Eisaburo Sueoka; Y Miyazaki; S Okabe; M Kurosumi; S Takayama; Hirota Fujiki
Molecular pathogenesis of interstitial pneumonitis with TNF-alpha transgenic mice.
Cytokine 1998;10(2):124-31.
1997: In Kyoung Lim; Hee-Jae Joo; K S Choi; Eisaburo Sueoka; Myung Soog Lee; Min Sook Ryu; Hirota Fujiki
Protection of 5alpha-dihydrotestosterone against TGF-beta-induced apoptosis in FaO cells and induction of mitosis in HepG2 cells.
International journal of cancer. Journal international du cancer 1997;72(2):351-5.
1997: S Okabe; Masami Suganuma; M Hayashi; Eisaburo Sueoka; A Komori; Hirota Fujiki
Mechanisms of growth inhibition of human lung cancer cell line, PC-9, by tea polyphenols.
Japanese journal of cancer research : Gann 1997;88(7):639-43.
1997: Eisaburo Sueoka; Naoko Sueoka; S Okabe; T Kozu; A Komori; T Ohta; Masami Suganuma; S J Kim; In Kyoung Lim; Hirota Fujiki
Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes.
Journal of cancer research and clinical oncology 1997;123(8):413-9.
1996: Hirota Fujiki; Masami Suganuma; S Okabe; A Komori; Eisaburo Sueoka; Naoko Sueoka; T Kozu; Y Sakai
Japanese green tea as a cancer preventive in humans.
Nutrition reviews 1996;54(11 Pt 2):S67-70.
1996: Naoko Sueoka; Eisaburo Sueoka; S Okabe; Hirota Fujiki
Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression.
Carcinogenesis 1996;17(11):2337-41.
1996: A Komori; S Okabe; Masami Suganuma; M A Kerr; J Busch-Petersen; L M Oh; J Zhuo; G S Kannangara; X Zou; Marcus A Tius; Hirota Fujiki
Anti-tumor promoting activity of canventol and its synthetic analogs through inhibition of protein isoprenylation.
Japanese journal of cancer research : Gann 1996;87(9):875-81.
1996: Masami Suganuma; S Okabe; Eisaburo Sueoka; N Iida; A Komori; Seong-Jin Kim; Hirota Fujiki
A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression.
Cancer research 1996;56(16):3711-5.
1996: T Kozu; Eisaburo Sueoka; S Okabe; Naoko Sueoka; A Komori; Hirota Fujiki
In vitro catalytic activities of DNA/RNA chimeric hammerhead ribozymes against AML1-MTG8 mRNA, a fused gene transcript in acute myeloid leukemia with t(8;21).
Biochimie 1996;78(11-12):1067-73.
1996: T Kozu; Eisaburo Sueoka; S Okabe; Naoko Sueoka; A Komori; Hirota Fujiki
Designing of chimeric DNA/RNA hammerhead ribozymes to be targeted against AML1/MTG8 mRNA.
Journal of cancer research and clinical oncology 1996;122(4):254-6.
1995: Eisaburo Sueoka; S Nishiwaki; S Okabe; N Iida; Masami Suganuma; I Yano; K Aoki; Hirota Fujiki
Activation of protein kinase C by mycobacterial cord factor, trehalose 6-monomycolate, resulting in tumor necrosis factor-alpha release in mouse lung tissues.
Japanese journal of cancer research : Gann 1995;86(8):749-55.
1995: Masami Suganuma; S Okabe; Eisaburo Sueoka; R Nishiwaki; A Komori; N Uda; K Isono; Hirota Fujiki
Tautomycin: an inhibitor of protein phosphatases 1 and 2A but not a tumor promoter on mouse skin and in rat glandular stomach.
Journal of cancer research and clinical oncology 1995;121(9-10):621-7.
1994: Toshihisa Ohta; Eisaburo Sueoka; N Iida; A Komori; Masami Suganuma; R Nishiwaki; M Tatematsu; Seong-Jin Kim; W W Carmichael; Hirota Fujiki
Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver.
Cancer research 1994;54(24):6402-6.
1994: R Nishiwaki; Toshihisa Ohta; Eisaburo Sueoka; Masami Suganuma; K Harada; M F Watanabe; Hirota Fujiki
Two significant aspects of microcystin-LR: specific binding and liver specificity.
Cancer letters 1994;83(1-2):283-9.
1994: Hirota Fujiki; Masami Suganuma
Tumor necrosis factor-alpha, a new tumor promoter, engendered by biochemical studies of okadaic acid.
Journal of biochemistry 1994;115(1):1-5.
1994: Hirota Fujiki; Masami Suganuma; A Komori; J Yatsunami; S Okabe; Toshihisa Ohta; Eisaburo Sueoka
A new tumor promotion pathway and its inhibitors.
Cancer detection and prevention 1994;18(1):1-7.
1993: A Komori; Masami Suganuma; S Okabe; X Zou; Marcus A Tius; Hirota Fujiki
Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation.
Cancer research 1993;53(15):3462-4.
1993: Masami Suganuma; Hirota Fujiki
[Inhibitors of protein phosphatases].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(11):1960-70.
1993: A Komori; J Yatsunami; S Okabe; S Abe; K Hara; Masami Suganuma; S J Kim; Hirota Fujiki
Anticarcinogenic activity of green tea polyphenols.
Japanese journal of clinical oncology 1993;23(3):186-90.
1993: A Komori; J Yatsunami; Masami Suganuma; S Okabe; S Abe; A Sakai; K Sasaki; Hirota Fujiki
Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation.
Cancer research 1993;53(9):1982-5.
1993: Masami Suganuma; J Yatsunami; S Yoshizawa; S Okabe; Hirota Fujiki
Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin.
Cancer research 1993;53(5):1012-6.
1993: J Yatsunami; A Komori; Toshihisa Ohta; Masami Suganuma; S H Yuspa; Hirota Fujiki
Hyperphosphorylation of cytokeratins by okadaic acid class tumor promoters in primary human keratinocytes.
Cancer research 1993;53(5):992-6.
1993: J Yatsunami; A Komori; Toshihisa Ohta; Masami Suganuma; Hirota Fujiki
Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter.
Cancer research 1993;53(2):239-41.
1993: Hirota Fujiki; Masami Suganuma
Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds.
Advances in cancer research 1993;61():143-94.
1993: J Yatsunami; Hirota Fujiki
[Recent advance of the study of okadaic acid class tumor promoters].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(1):26-35.
1992: Toshihisa Ohta; R Nishiwaki; J Yatsunami; A Komori; Masami Suganuma; Hirota Fujiki
Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes.
Carcinogenesis 1992;13(12):2443-7.
1992: Masami Suganuma; M Tatematsu; J Yatsunami; S Yoshizawa; S Okabe; D Uemura; Hirota Fujiki
An alternative theory of tissue specificity by tumor promotion of okadaic acid in glandular stomach of SD rats.
Carcinogenesis 1992;13(10):1841-5.
1992: Masami Suganuma; Hirota Fujiki; S Okabe; S Nishiwaki; D Brautigan; T S Ingebritsen; M R Rosner
Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity.
Toxicon : official journal of the International Society on Toxinology 1992;30(8):873-8.
1992: Hirota Fujiki; S Yoshizawa; T Horiuchi; Masami Suganuma; J Yatsunami; S Nishiwaki; S Okabe; R Nishiwaki-Matsushima; T Okuda; T Sugimura
Anticarcinogenic effects of (-)-epigallocatechin gallate.
Preventive medicine 1992;21(4):503-9.
1992: Hirota Fujiki; Masami Suganuma; S Nishiwaki; S Yoshizawa; J Yatsunami; R Matsushima; H Furuya; S Okabe; S Matsunaga; T Sugimura
Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway.
Progress in clinical and biological research 1992;374():337-50.
1992: R Nishiwaki-Matsushima; Toshihisa Ohta; S Nishiwaki; Masami Suganuma; K Kohyama; T Ishikawa; Wayne W Carmichael; Hirota Fujiki
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR.
Journal of cancer research and clinical oncology 1992;118(6):420-4.
1992: Hirota Fujiki
Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?
Molecular carcinogenesis 1992;5(2):91-4.
1992: J Yatsunami; Hirota Fujiki; A Komori; Masami Suganuma; S Nishiwaki; S Okabe; R Nishiwaki-Matsushima; Toshihisa Ohta; S Matsunaga; N Fusetani
Marine natural products against tumor development.
Journal of nutritional science and vitaminology 1992;Spec No():333-6.
1991: R Nishiwaki-Matsushima; S Nishiwaki; Toshihisa Ohta; S Yoshizawa; Masami Suganuma; K Harada; Masahiko Watanabe; Hirota Fujiki
Structure-function relationships of microcystins, liver tumor promoters, in interaction with protein phosphatase.
Japanese journal of cancer research : Gann 1991;82(9):993-6.
1991: S Nishiwaki; Hirota Fujiki; S Yoshizawa; Masami Suganuma; H Furuya-Suguri; S Okabe; M Nakayasu; K Okabe; H Muratake; M Natsume
Pendolmycin, a new tumor promoter of the teleocidin A class on skin of CD-1 mice.
Japanese journal of cancer research : Gann 1991;82(7):779-83.
1991: J Yatsunami; Hirota Fujiki; Masami Suganuma; S Yoshizawa; J E Eriksson; M O Olson; R D Goldman
Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid.
Biochemical and biophysical research communications 1991;177(3):1165-70.
1991: Hirota Fujiki; Masami Suganuma; S Yoshizawa; S Nishiwaki; B Winyar; T Sugimura
Mechanisms of action of okadaic acid class tumor promoters on mouse skin.
Environmental health perspectives 1991;93():211-4.
1991: S Matsunaga; H Furuya-Suguri; S Nishiwaki; S Yoshizawa; Masami Suganuma; T Hashimoto; Y Asakawa; Hirota Fujiki
Differential effects of cryptoporic acids D and E, inhibitors of superoxide anion radical release, on tumor promotion of okadaic acid in mouse skin.
Carcinogenesis 1991;12(6):1129-31.
1991: S Nishiwaki; Hirota Fujiki; Masami Suganuma; R Nishiwaki-Matsushima; T Sugimura
Rapid purification of protein phosphatase 2A from mouse brain by microcystin-affinity chromatography.
FEBS letters 1991;279(1):115-8.
1991: J Yatsunami; Hirota Fujiki; Masami Suganuma; S Nishiwaki; M Ojika; K Yamada; L Levine
Binding competition of okadaic acid derivatives to anti-okadaic acid antibody.
Toxicon : official journal of the International Society on Toxinology 1991;29(11):1409-12.
1990: S Nishiwaki; Hirota Fujiki; Masami Suganuma; H Furuya-Suguri; R Matsushima; Y Iida; M Ojika; K Yamada; D Uemura; T Yasumoto
Structure-activity relationship within a series of okadaic acid derivatives.
Carcinogenesis 1990;11(10):1837-41.
1990: R Matsushima; S Yoshizawa; Masahiko Watanabe; K Harada; M Furusawa; Wayne W Carmichael; Hirota Fujiki
In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts.
Biochemical and biophysical research communications 1990;171(2):867-74.
1990: S Nishiwaki; Hirota Fujiki; Masami Suganuma; M Ojika; K Yamada; T Sugimura
Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7-O-(4-azidobenzoyl)okadaate.
Biochemical and biophysical research communications 1990;170(3):1359-64.
1990: S Yoshizawa; Hirota Fujiki; H Suguri; Masami Suganuma; M Nakayasu; R Matsushima; T Sugimura
Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin.
Cancer research 1990;50(16):4974-8.
1990: Masami Suganuma; Hirota Fujiki; H Furuya-Suguri; S Yoshizawa; S Yasumoto; Y Kato; N Fusetani; T Sugimura
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin.
Cancer research 1990;50(12):3521-5.
1990: S Yoshizawa; R Matsushima; Masahiko Watanabe; K Harada; A Ichihara; Wayne W Carmichael; Hirota Fujiki
Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity.
Journal of cancer research and clinical oncology 1990;116(6):609-14.
1990: Hirota Fujiki; Masami Suganuma; S Nishiwaki; S Yoshizawa; B Winyar; T Sugimura; F J Schmitz
A new pathway of tumor promotion by the okadaic acid class compounds.
Advances in second messenger and phosphoprotein research 1990;24():340-4.
1990: Hirota Fujiki; Masami Suganuma; H Suguri; K Takagi; S Yoshizawa; A Ootsuyama; Hiroshi Tanooka; T Okuda; M Kobayashi; T Sugimura
New antitumor promoters: (-)-epigallocatechin gallate and sarcophytols A and B.
Basic life sciences 1990;52():205-12.
1989: Masami Suganuma; maitree suttajit; H Suguri; M Ojika; K Yamada; Hirota Fujiki
Specific binding of okadaic acid, a new tumor promoter in mouse skin.
FEBS letters 1989;250(2):615-8.
1989: T Sassa; W W Richter; N Uda; Masami Suganuma; H Suguri; S Yoshizawa; M Hirota; Hirota Fujiki
Apparent "activation" of protein kinases by okadaic acid class tumor promoters.
Biochemical and biophysical research communications 1989;159(3):939-44.
1989: Hirota Fujiki; Masami Suganuma; H Suguri; S Yoshizawa; M Hirota; K Takagi; T Sugimura
Diversity in the chemical nature and mechanism of response to tumor promoters.
Progress in clinical and biological research 1989;298():281-91.
1989: Hirota Fujiki; Masami Suganuma; S Yoshizawa; H Kanazawa; T Sugimura; S Manam; S M Kahn; W Jiang; S Hoshina; I Bernard Weinstein
Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters.
Molecular carcinogenesis 1989;2(4):184-7.
1989: Hirota Fujiki; Masami Suganuma; H Suguri; S Yoshizawa; K Takagi; M Kobayashi
Sarcophytols A and B inhibit tumor promotion by teleocidin in two-stage carcinogenesis in mouse skin.
Journal of cancer research and clinical oncology 1989;115(1):25-8.
1988: M Hirota; maitree suttajit; H Suguri; Y Endo; K Shudo; V Wongchai; E Hecker; Hirota Fujiki
A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diester of 12-deoxy-16-hydroxyphorbol.
Cancer research 1988;48(20):5800-4.
1988: Hirota Fujiki; Masami Suganuma; H Suguri; S Yoshizawa; K Takagi; N Uda; K Wakamatsu; K Yamada; M Murata; T Yasumoto
Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin.
Japanese journal of cancer research : Gann 1988;79(10):1089-93.
1988: Hirota Fujiki; Masami Suganuma; M Ninomiya; S Yoshizawa; K Yamashita; S Takayama; Y Hitotsuyanagi; S Sakai; Koichi Shudo; T Sugimura
Similar, potent tumor-promoting activity of all isomers of teleocidins A and B in a two-stage carcinogenesis experiment on the skin of CD-1 mice.
Cancer research 1988;48(15):4211-4.
1988: M Ninomiya; Masami Suganuma; N S Paik; Y Muto; Hirota Fujiki
Specific binding of [3H]retinoids to cellular retinoid-binding proteins.
FEBS letters 1988;233(2):255-8.
1988: Masami Suganuma; Hirota Fujiki; H Suguri; S Yoshizawa; M Hirota; M Nakayasu; M Ojika; K Wakamatsu; K Yamada; T Sugimura
Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1768-71.
1988: K Takagi; Masami Suganuma; H Kagechika; K Shudo; M Ninomiya; Y Muto; Hirota Fujiki
Inhibition of ornithine decarboxylase induction by retinobenzoic acids in relation to their binding affinities to cellular retinoid-binding proteins.
Journal of cancer research and clinical oncology 1988;114(3):221-4.
1987: T Horiuchi; Hirota Fujiki; M Hirota; maitree suttajit; Masami Suganuma; A Yoshioka; V Wongchai; E Hecker; T Sugimura
Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand.
Japanese journal of cancer research : Gann 1987;78(3):223-6.
1987: Hirota Fujiki; T Sugimura
New classes of tumor promoters: teleocidin, aplysiatoxin, and palytoxin.
Advances in cancer research 1987;49():223-64.
1986: S Sakai; Y Hitotsuyanagi; K Yamaguchi; N Aimi; K Ogata; T Kuramochi; H Seki; R Hara; Hirota Fujiki; Masami Suganuma
The structures of additional teleocidin class tumor promoters.
Chemical & pharmaceutical bulletin 1986;34(11):4883-6.
1986: M Ninomiya; Hirota Fujiki; N S Paik; T Horiuchi; R K Boutwell
Absence of phosphorylation of retinoid-binding proteins by protein kinase C in vitro.
Biochemical and biophysical research communications 1986;138(1):330-4.
1986: K Ohuchi; N Hirasawa; C Takahashi; M Watanabe; S Tsurufuji; Hirota Fujiki; Masami Suganuma; H Hakii; T Sugimura; S B Christensen
Synergistic stimulation of histamine release from rat peritoneal mast cells by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters.
Biochimica et biophysica acta 1986;887(1):94-9.
1986: Hirota Fujiki; Masami Suganuma; M Nakayasu; H Hakii; T Horiuchi; S Takayama; T Sugimura
Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis.
Carcinogenesis 1986;7(5):707-10.
1986: M Ninomiya; Hirota Fujiki; N S Paik; H Hakii; Masami Suganuma; Y Hitotsuyanagi; N Aimi; S Sakai; Y Endo; Koichi Shudo
Des-O-methylolivoretin C is a new member of the teleocidin class of tumor promoters.
Japanese journal of cancer research : Gann 1986;77(3):222-5.
1986: H Hakii; Hirota Fujiki; Masami Suganuma; M Nakayasu; T Tahira; T Sugimura; P J Scheuer; S B Christensen
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis.
Journal of cancer research and clinical oncology 1986;111(3):177-81.
1984: Y Hitotsuyanagi; Hirota Fujiki; Masami Suganuma; N Aimi; S Sakai; Y Endo; Koichi Shudo; T Sugimura
Isolation and structure elucidation of teleocidin B-1, B-2, B-3, and B-4.
Chemical & pharmaceutical bulletin 1984;32(10):4233-6.
1984: T Horiuchi; Hirota Fujiki; Masami Suganuma; H Hakii; M Nakayasu; Y Hitotsuyanagi; N Aimi; S Sakai; Y Endo; Koichi Shudo
Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity.
Gann = Gan 1984;75(10):837-40.