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Manabu Fujimoto

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Doanh Le Huu; Takashi Matsushita; Kazuhiko Takehara; Thomas F Tedder; Yasuhito Hamaguchi; Minoru Hasegawa; Guihua Jin; Manabu Fujimoto
Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.
Manabu Fujimoto
[Myositis-specific autoantibodies].
Minoru Hasegawa; Kiyoshi Higashi; Takashi Matsushita; Koichi Saito; Manabu Fujimoto; Yasuhito Hamaguchi; Kazuhiko Takehara
Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.

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2013: Doanh Le Huu; Takashi Matsushita; Kazuhiko Takehara; Thomas F Tedder; Yasuhito Hamaguchi; Minoru Hasegawa; Guihua Jin; Manabu Fujimoto
Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.
Blood 2013;121(16):3274-83.
2013: Manabu Fujimoto
[Myositis-specific autoantibodies].
Brain and nerve = Shinkei kenkyū no shinpo 2013;65(4):449-60.
2013: Minoru Hasegawa; Kiyoshi Higashi; Takashi Matsushita; Koichi Saito; Manabu Fujimoto; Yasuhito Hamaguchi; Kazuhiko Takehara
Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.
Journal of dermatological science 2013;70(1):34-41.
2013: Minako Arai; Sonoko Chujo; Manabu Fujimoto; Yasuhito Hamaguchi; Minoru Hasegawa; Yuka Ikawa; Wataru Ishida; Naofumi Mukaida; Fumiaki Shirasaki; Kazuhiko Takehara
Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis.
Journal of dermatological science 2013;69(3):250-8.
2013: Minoru Hasegawa; Sayako Imura-Kumada; Takashi Matsushita; Manabu Fujimoto; Yasuhito Hamaguchi; Kazuhiko Takehara
Anti-topoisomerase I antibody levels as serum markers of skin sclerosis in systemic sclerosis.
The Journal of dermatology 2013;40(2):89-93.
2013: Minoru Hasegawa; Takashi Matsushita; Manabu Fujimoto; Yasuhito Hamaguchi; Kazuhiko Takehara
Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis.
Rheumatology (Oxford, England) 2013;52(2):242-51.
2013: Yasuhito Hamaguchi; Minoru Hasegawa; Kenzo Kaji; Masanari Kodera; Kazuhiro Komura; Takashi Matsushita; Eiji Muroi; Shinichi Sato; Mariko Seishima; Kazuhiko Takehara; Hidehiro Yamada; Ryo Yamada; Keita Fujikawa; Manabu Fujimoto; Masataka Kuwana
Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome.
PloS one 2013;8(4):e60442.
2013: Ikuko Ueda-Hayakawa; Yasuhito Hamaguchi; Minoru Hasegawa; Kazuhiko Takehara; Manabu Fujimoto
Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts.
Journal of dermatological science 2013;69(1):54-60.
2013: Yoshiro Horai; Eriko Isomoto; Manabu Fujimoto; Yasuhito Hamaguchi; Shin-Ya Kawashiri; Tomohiro Koga; Masataka Kuwana; Hideki Nakamura; Akitomo Okada; Tomoki Origuchi; Mami Tamai; Satoshi Yamasaki; Atsushi Kawakami
Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease: a report of two cases.
Modern rheumatology / the Japan Rheumatism Association 2013;23(1):190-4.
2012: Minoru Hasegawa; Takashi Matsushita; Hidemitsu Orito; Manabu Fujimoto; Yasuhito Hamaguchi; Kazuhiko Takehara
Two cases of livedo vasculopathy with non-criteria antiphospholipid antibodies.
The Journal of dermatology 2012;39(12):1026-30.
2012: Doanh Le Huu; Takashi Matsushita; Kazuhiko Takehara; Yasuhito Hamaguchi; Minoru Hasegawa; Guihua Jin; Manabu Fujimoto
IL-6 blockade attenuates the development of murine sclerodermatous chronic graft-versus-host disease.
The Journal of investigative dermatology 2012;132(12):2752-61.
2012: Yoshinobu Okamoto; Manabu Fujimoto; Yasuhito Hamaguchi; Minoru Hasegawa; Doanh Le Huu; Yoichiro Iwakura; Takashi Matsushita; Kazuhiko Takehara
Potential roles of interleukin-17A in the development of skin fibrosis in mice.
Arthritis and rheumatism 2012;64(11):3726-35.
2012: Minoru Hasegawa; Takashi Matsushita; Hidemitsu Orito; Manabu Fujimoto; Yasuhito Hamaguchi; Keiko Yamamoto; Kazuhiko Takehara
Skin sclerosis as a manifestation of POEMS syndrome.
The Journal of dermatology 2012;39(11):922-6.
2012: Sayako Imura-Kumada; Takashi Matsushita; Gary L Norman; Zakera Shums; Kazuhiko Takehara; Susan Encabo; Yasuhito Hamaguchi; Minoru Hasegawa; Manabu Fujimoto
High prevalence of primary biliary cirrhosis and disease-associated autoantibodies in Japanese patients with systemic sclerosis.
Modern rheumatology / the Japan Rheumatism Association 2012;22(6):892-8.
2012: Guihua Jin; Hajime Karasuyama; Doanh Le Huu; Takashi Matsushita; Kazushige Obata; Kazuhiko Takehara; Yasuhito Hamaguchi; Minoru Hasegawa; Takayuki Ishii; Manabu Fujimoto
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction.
Journal of dermatological science 2012;67(3):181-9.
2012: Tomohiro Koga; Shigeru Kohno; Masataka Kuwana; Hiroshi Mukae; Hideki Nakamura; Yoshikazu Nakashima; Akitomo Okada; Tomoki Origuchi; Takahisa Suzuki; Mami Tamai; Satoshi Yamasaki; Kiyoshi Aoyagi; Kazuhiko Arima; Katsumi Eguchi; Keita Fujikawa; Manabu Fujimoto; Yasuhito Hamaguchi; Yoshiro Horai; Yuji Ishimatsu; Naoki Iwamoto; Shin-Ya Kawashiri; Atsushi Kawakami
The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM.
Rheumatology (Oxford, England) 2012;51(7):1278-84.
2012: Manabu Fujimoto; Yasuhito Hamaguchi; Minoru Hasegawa; Naohito Hatta; Akira Higashi; Kenji Hirose; Yuki Ichimura; Atsuyuki Igarashi; Naoko Ishiguro; Kenzo Kaji; Masanari Kodera; Eriko Mabuchi; Takashi Matsushita; Takuya Miyagi; Fumihide Ogawa; Mariko Seishima; Narihiro Akimoto; Yoshihide Asano; Keita Fujikawa; Kiyohiro Tsutsui; Ikuko Ueda-Hayakawa; Kazuhiko Takehara
Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins.
Arthritis and rheumatism 2012;64(2):513-22.
2011: Shinji Noda; Makoto Sugaya; Tomonori Takekoshi; Zenshiro Tamaki; Mizuho Yamamoto; Yoshihide Asano; Takafumi Etoh; Manabu Fujimoto; Megumi Hirabayashi; Toshihiko Hoashi; Kenzo Kaji; Masataka Kuwana; Rieko Morimoto; Shinichi Sato
Dermatomyositis with anti-OJ antibody.
Rheumatology international 2011;31(12):1673-5.
2011: Shintaro Maeda; Takashi Matsushita; Kazuhiko Takehara; Manabu Fujimoto; Yasuhito Hamaguchi; Minoru Hasegawa
Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production.
The American journal of pathology 2011;179(5):2360-9.
2011: Toshifumi Yamaoka; Koichi Yanaba; Ayumi Yoshizaki; Kazuhiro Shimizu; Yuichiro Akiyama; Sang Jae Bae; Manabu Fujimoto; Yohei Iwata; Kazuhiro Komura; E Muroi; Fumihide Ogawa; Shinichi Sato
The roles of P- and E-selectins and P-selectin glycoprotein ligand-1 in primary and metastatic mouse melanomas.
Journal of dermatological science 2011;64(2):99-107.
2011: Naoki Mugii; Minoru Hasegawa; Takashi Matsushita; Yasuhito Hamaguchi; Sho Horie; Tetsutarou Yahata; Katsumi Inoue; Fujiko Someya; Manabu Fujimoto; Kazuhiko Takehara
Association between nail-fold capillary findings and disease activity in dermatomyositis.
Rheumatology (Oxford, England) 2011;50(6):1091-8.
2011: Minoru Hasegawa; Manabu Fujimoto; Yasuhito Hamaguchi; Takashi Matsushita; Katsumi Inoue; Shinichi Sato; Kazuhiko Takehara
Use of serum clara cell 16-kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis.
The Journal of rheumatology 2011;38(5):877-84.
2011: Minoru Hasegawa; Manabu Fujimoto; Takashi Matsushita; Yasuhito Hamaguchi; Kazuhiko Takehara; Shinichi Sato
Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis.
Clinical rheumatology 2011;30(2):231-7.
2011: Yasuhito Hamaguchi; Mitsuhiro Kawano; Seiko Kitamura-Sawada; Yukiyo Matsushita; Manabu Fujimoto; Kazuhiko Takehara
IgG4-related skin disease, a mimic of angiolymphoid hyperplasia with eosinophilia.
Dermatology (Basel, Switzerland) 2011;223(4):301-5.
2011: Ayumi Yoshizaki; Koichi Yanaba; Yohei Iwata; Kazuhiro Komura; Asako Ogawa; E Muroi; Fumihide Ogawa; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation.
Annals of the rheumatic diseases 2011;70(1):194-200.
2010: Ikuko Ueda-Hayakawa; Minoru Hasegawa; Sayako Kumada; Chihiro Tanaka; Kazuhiro Komura; Yasuhito Hamaguchi; Kazuhiko Takehara; Manabu Fujimoto
Usefulness of anti-cyclic citrullinated peptide antibody and rheumatoid factor to detect rheumatoid arthritis in patients with systemic sclerosis.
Rheumatology (Oxford, England) 2010;49(11):2135-9.
2010: Manabu Fujimoto
Regulatory B cells in skin and connective tissue diseases.
Journal of dermatological science 2010;60(1):1-7.
2010: Ayumi Yoshizaki; Koichi Yanaba; Yohei Iwata; Kazuhiro Komura; Asako Ogawa; Yuichiro Akiyama; E Muroi; T Hara; Fumihide Ogawa; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Thomas F Tedder; Shinichi Sato
Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2502-15.
2010: Ayumi Yoshizaki; Koichi Yanaba; Asako Yoshizaki; Yohei Iwata; Kazuhiro Komura; Fumihide Ogawa; Motoi Takenaka; Kazuhiro Shimizu; Yoshihide Asano; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis.
Arthritis and rheumatism 2010;62(8):2476-87.
2010: Yasuhito Hamaguchi; Manabu Fujimoto; Yuri Enokido; Takamasa Wayaku; Kenzo Kaji; Takeshi Echigo; Kazuhiko Takehara
Intractable genital ulcers from herpes simplex virus reactivation in drug-induced hypersensitivity syndrome caused by allopurinol.
International journal of dermatology 2010;49(6):700-4.
2010: Yasuhito Hamaguchi; Minoru Hasegawa; Chihiro Tanaka; Sayako Kumada; Shinichi Sato; Kazuhiko Takehara; Manabu Fujimoto
Elevated serum placenta growth factor (PlGF) levels in patients with systemic sclerosis: a possible role in the development of skin but not lung fibrosis.
Journal of dermatological science 2010;58(3):229-31.
2010: Chihiro Tanaka; Manabu Fujimoto; Yasuhito Hamaguchi; Shinichi Sato; Kazuhiko Takehara; Minoru Hasegawa
Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway.
Arthritis and rheumatism 2010;62(6):1723-32.
2010: Asako Ogawa; Ayumi Yoshizaki; Koichi Yanaba; Fumihide Ogawa; T Hara; E Muroi; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Thomas F Tedder; Shinichi Sato
The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.
The Journal of investigative dermatology 2010;130(6):1558-70.
2010: Shihoko Okazaki; Fumihide Ogawa; Yohei Iwata; T Hara; E Muroi; Kazuhiro Komura; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis.
Rheumatology international 2010;30(7):871-8.
2010: Hajime Tomita; Fumihide Ogawa; T Hara; Koichi Yanaba; Yohei Iwata; E Muroi; Ayumi Yoshizaki; Kazuhiro Komura; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Elevated serum concentrations of triggering receptor expressed on myeloid cells-1 in diffuse cutaneous systemic sclerosis: association with severity of pulmonary fibrosis.
The Journal of rheumatology 2010;37(4):787-91.
2010: Hiroko Nakashima; Manabu Fujimoto; Rei Watanabe; Nobuko Ishiura; Akemi Ishida Yamamoto; Takashi Hashimoto; Kunihiko Tamaki
Herpetiform pemphigus without anti-desmoglein 1/3 autoantibodies.
The Journal of dermatology 2010;37(3):264-8.
2010: M Odaka; Minoru Hasegawa; Y Hamaguchi; N Ishiura; S Kumada; Takashi Matsushita; Kazuhiro Komura; Shinichi Sato; Kazuhiko Takehara; Manabu Fujimoto
Autoantibody-mediated regulation of B cell responses by functional anti-CD22 autoantibodies in patients with systemic sclerosis.
Clinical and experimental immunology 2010;159(2):176-84.
2010: Koichi Yanaba; Ayumi Yoshizaki; E Muroi; T Hara; Fumihide Ogawa; Kazuo Shimizu; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
CCL13 is a promising diagnostic marker for systemic sclerosis.
The British journal of dermatology 2010;162(2):332-6.
2010: T Hara; Kazuhiro Shimizu; Fumihide Ogawa; Koichi Yanaba; Yohei Iwata; E Muroi; Motoi Takenaka; Kazuhiro Komura; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction.
The American journal of pathology 2010;176(1):259-69.
2010: Fumihide Ogawa; Kazuhiro Shimizu; T Hara; E Muroi; Kazuhiro Komura; Motoi Takenaka; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage.
Archives of dermatological research 2010;302(1):27-35.
2010: Yasuhito Hamaguchi; Manabu Fujimoto; Minoru Hasegawa; Takashi Matsushita; Kazuhiko Takehara
Re-emergence of anti-topoisomerase I antibody with exacerbated development of skin sclerosis in a patient with systemic sclerosis.
Journal of the American Academy of Dermatology 2010;62(1):142-4.
2009: Minoru Hasegawa; Yukiyo Matsushita; Mayuka Horikawa; Kiyoshi Higashi; Yoshitaka Tomigahara; Hideo Kaneko; Fumiaki Shirasaki; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis.
Arthritis and rheumatism 2009;60(11):3465-75.
2009: Y Akiyama; Fumihide Ogawa; Y Iwata; Kazuhiro Komura; T Hara; E Muroi; Sang-Jae Bae; Motoi Takenaka; Kazuo Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Autoantibody against activating transcription factor-2 in patients with systemic sclerosis.
Clinical and experimental rheumatology 2009;27(5):751-7.
2009: Koichi Yanaba; E Muroi; Ayumi Yoshizaki; T Hara; Fumihide Ogawa; Kazuhiro Shimizu; Mariko Yozaki; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
Serum CXCL16 concentrations correlate with the extent of skin sclerosis in patients with systemic sclerosis.
The Journal of rheumatology 2009;36(9):1917-23.
2009: Yohei Iwata; Ayumi Yoshizaki; Kazuhiro Komura; Kazuhiro Shimizu; Fumihide Ogawa; T Hara; E Muroi; Sangjae Bae; Motoi Takenaka; Toru Yukami; Minoru Hasegawa; Manabu Fujimoto; Yasushi Tomita; Thomas F Tedder; Shinichi Sato
CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling.
The American journal of pathology 2009;175(2):649-60.
2009: Koichi Yanaba; Ayumi Yoshizaki; E Muroi; T Hara; Fumihide Ogawa; Aya Usui; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
Elevated circulating TWEAK levels in systemic sclerosis: association with lower frequency of pulmonary fibrosis.
The Journal of rheumatology 2009;36(8):1657-62.
2009: Hajime Tomita; Yohei Iwata; Fumihide Ogawa; Kazuhiro Komura; Kazuhiro Shimizu; Ayumi Yoshizaki; Toshihide Hara; E Muroi; Koichi Yanaba; Sangjae Bae; Motoi Takenaka; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand.
The Journal of investigative dermatology 2009;129(8):2059-67.
2009: Yasuhito Hamaguchi; Manabu Fujimoto; Minoru Hasegawa; Takashi Matsushita; Kazuhiko Takehara
Bosentan increases serum IL-12 levels in systemic sclerosis patients with pulmonary arterial hypertension.
Journal of dermatological science 2009;55(1):66-7.
2009: Takayuki Ishii; Tomoyuki Fujita; Takashi Matsushita; Koichi Yanaba; Minoru Hasegawa; Hiroko Nakashima; Fumihide Ogawa; Kazuhiro Shimizu; Kazuhiko Takehara; Thomas F Tedder; Shinichi Sato; Manabu Fujimoto
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction.
The American journal of pathology 2009;174(6):2225-33.
2009: Yohei Iwata; Ayumi Yoshizaki; Fumihide Ogawa; Kazuhiro Komura; T Hara; E Muroi; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
Increased serum pentraxin 3 in patients with systemic sclerosis.
The Journal of rheumatology 2009;36(5):976-83.
2009: T Miyagaki; Makoto Sugaya; Shinji Kagami; Hiroko Nakashima; Nobuko Ishiura; Rei Watanabe; H Ohmatsu; Hideki Fujita; Norihito Yazawa; Takafumi Kadono; Manabu Fujimoto; Hidehisa Saeki; Kunihiko Tamaki
Increased CCL1 levels in the sera and blister fluid of patients with bullous pemphigoid.
Journal of dermatological science 2009;54(1):45-7.
2009: Ayumi Yoshizaki; Kazuhiro Komura; Yohei Iwata; Fumihide Ogawa; T Hara; E Muroi; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity.
Journal of clinical immunology 2009;29(2):180-9.
2009: Yutaka Kuwatsuka; Fumihide Ogawa; Yohei Iwata; Kazuhiro Komura; E Muroi; T Hara; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis.
Autoimmunity 2009;42(2):120-5.
2009: Keita Fujikawa; Atsushi Kawakami; K Kaji; Manabu Fujimoto; S Kawashiri; N Iwamoto; Toshiyuki Aramaki; K Ichinose; Mami Tamai; Makoto Kamachi; Hideki Nakamura; Hiroaki Ida; Tomoki Origuchi; H Ishimoto; H Mukae; M Kuwana; Shigeru Kohno; Kazuhiko Takehara; Shinichi Sato; Katsumi Eguchi
Association of distinct clinical subsets with myositis-specific autoantibodies towards anti-155/140-kDa polypeptides, anti-140-kDa polypeptides, and anti-aminoacyl tRNA synthetases in Japanese patients with dermatomyositis: a single-centre, cross-sectional study.
Scandinavian journal of rheumatology 2009;38(4):263-7.
2009: T Hara; Fumihide Ogawa; Koichi Yanaba; Yohei Iwata; E Muroi; Kazuhiro Komura; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
The Journal of rheumatology 2009;36(1):99-105.
2008: T Yamaoka; Fumihide Ogawa; E Muroi; T Hara; Kazuhiro Komura; Y Iwata; M Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato
Autoantibody against a protease domain of caspase-8 in patients with systemic sclerosis.
Clinical and experimental rheumatology 2008;26(6):998-1004.
2008: Takashi Matsushita; Koichi Yanaba; Jean-David Bouaziz; Manabu Fujimoto; Thomas F Tedder
Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.
The Journal of clinical investigation 2008;118(10):3420-30.
2008: Yuka Ikawa; Poh-Sing Ng; Koki Endo; Miki Kondo; Sonoko Chujo; Wataru Ishida; Fumiaki Shirasaki; Manabu Fujimoto; Kazuhiko Takehara
Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor-beta-induced mouse fibrosis.
Journal of cellular physiology 2008;216(3):680-7.
2008: Yuki Saito; Minoru Hasegawa; Manabu Fujimoto; Takashi Matsushita; Mayuka Horikawa; Motoi Takenaka; Fumihide Ogawa; Junko Sugama; Douglas A Steeber; Shinichi Sato; Kazuhiko Takehara
The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer.
The Journal of investigative dermatology 2008;128(7):1838-51.
2008: Kazuhiro Komura; Manabu Fujimoto; Koichi Yanaba; Takashi Matsushita; Yukiyo Matsushita; Mayuka Horikawa; Fumihide Ogawa; K Shimizu; Minoru Hasegawa; Kazuhiko Takehara; Shinichi Sato
Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse.
Annals of the rheumatic diseases 2008;67(6):867-72.
2008: Koichi Yanaba; Jean-David Bouaziz; Karen M Haas; Jonathan C Poe; Manabu Fujimoto; Thomas F Tedder
A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.
Immunity 2008;28(5):639-50.
2008: Yasuhito Hamaguchi; Minoru Hasegawa; Manabu Fujimoto; Takashi Matsushita; Kazuhiro Komura; Kenzo Kaji; M Kondo; Chihiro Nishijima; Ikuko Hayakawa; F Ogawa; M Kuwana; Kazuhiko Takehara; Shinichi Sato
The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis.
The British journal of dermatology 2008;158(3):487-95.
2008: Takashi Matsushita; Manabu Fujimoto; Takeshi Echigo; Yukiyo Matsushita; Yuka Shimada; Minoru Hasegawa; Kazuhiko Takehara; Shinichi Sato
Elevated serum levels of APRIL, but not BAFF, in patients with atopic dermatitis.
Experimental dermatology 2008;17(3):197-202.
2008: Nobuko Ishiura; Manabu Fujimoto; Rei Watanabe; Hiroko Nakashima; Yoshihiro Kuwano; Norihito Yazawa; Takeshi Echigo; Hitoshi Okochi; Kunihiko Tamaki
Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid.
Journal of dermatological science 2008;49(2):153-61.
2008: Takashi Matsushita; Minoru Hasegawa; Fumiaki Shirasaki; Manabu Fujimoto; Hirohito Yamazaki; Shinichi Sato; Kazuhiko Takehara
A case of acute cutaneous graft-versus-host disease mimicking psoriasis vulgaris.
Dermatology (Basel, Switzerland) 2008;216(1):64-7.
2007: Takamasa Wayaku; Minoru Hasegawa; Kenzo Kaji; Miki Kondo; Yuki Saito; Hidemitsu Orito; Mayuka Horikawa; Takashi Matsushita; Kazuhiro Komura; Ikuko Hayakawa; Yasuhito Hamaguchi; Fumihide Ogawa; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies.
Rheumatology international 2007;28(2):113-9.
2007: Takashi Matsushita; Manabu Fujimoto; Minoru Hasegawa; Yukiyo Matsushita; Kazuhiro Komura; Fumihide Ogawa; Rei Watanabe; Kazuhiko Takehara; Shinichi Sato
BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice.
The Journal of investigative dermatology 2007;127(12):2772-80.
2007: Norihito Yazawa; Manabu Fujimoto; Kunihiko Tamaki
Recent advances on pathogenesis and therapies in systemic sclerosis.
Clinical reviews in allergy & immunology 2007;33(1-2):107-12.
2007: Takashi Matsushita; Manabu Fujimoto; Minoru Hasegawa; Chihiro Tanaka; Sayako Kumada; Fumihide Ogawa; Kazuhiko Takehara; Shinichi Sato
Elevated serum APRIL levels in patients with systemic sclerosis: distinct profiles of systemic sclerosis categorized by APRIL and BAFF.
The Journal of rheumatology 2007;34(10):2056-62.
2007: Charlene M Prazma; Norihito Yazawa; Yoko Fujimoto; Manabu Fujimoto; Thomas F Tedder
CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4550-62.
2007: Yoshihiro Kuwano; Manabu Fujimoto; Rei Watanabe; Nobuko Ishiura; Hiroko Nakashima; Mayumi Komine; Tatsuo S Hamazaki; Kunihiko Tamaki; Hitoshi Okochi
The involvement of Gab1 and PI 3-kinase in beta1 integrin signaling in keratinocytes.
Biochemical and biophysical research communications 2007;361(1):224-9.
2007: Toru Yukami; Minoru Hasegawa; Yukiyo Matsushita; Tomoyuki Fujita; Takashi Matsushita; Mayuka Horikawa; Kazuhiro Komura; Koichi Yanaba; Yasuhito Hamaguchi; Tetsuya Nagaoka; Fumihide Ogawa; Manabu Fujimoto; Douglas A Steeber; Thomas F Tedder; Kazuhiko Takehara; Shinichi Sato
Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1.
Journal of leukocyte biology 2007;82(3):519-31.
2007: Yoshihiro Kuwano; Manabu Fujimoto; Rei Watanabe; Nobuko Ishiura; Hiroko Nakashima; Y Ohno; Shoichiro Yano; Norihito Yazawa; Hitoshi Okochi; Kunihiko Tamaki
Serum chemokine profiles in patients with alopecia areata.
The British journal of dermatology 2007;157(3):466-73.
2007: Yoshihiro Kuwano; Charlene M Prazma; Norihito Yazawa; Rei Watanabe; Nobuko Ishiura; Atsushi Kumanogoh; Hitoshi Okochi; Kunihiko Tamaki; Manabu Fujimoto; Thomas F Tedder
CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells.
International immunology 2007;19(8):977-92.
2007: Rei Watanabe; Manabu Fujimoto; Nobuko Ishiura; Yoshihiro Kuwano; Hiroko Nakashima; Norihito Yazawa; Hitoshi Okochi; Shinichi Sato; Thomas F Tedder; Kunihiko Tamaki
CD19 expression in B cells is important for suppression of contact hypersensitivity.
The American journal of pathology 2007;171(2):560-70.
2007: Yukiyo Matsushita; Minoru Hasegawa; Takashi Matsushita; Manabu Fujimoto; Mayuka Horikawa; Tomoyuki Fujita; Ayako Kawasuji; Fumihide Ogawa; Douglas A Steeber; Thomas F Tedder; Kazuhiko Takehara; Shinichi Sato
Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):698-707.
2007: Tomoyuki Fujita; Manabu Fujimoto; Takashi Matsushita; Yuka Shimada; Minoru Hasegawa; Yoshihiro Kuwano; Fumihide Ogawa; Kazuhiko Takehara; Shinichi Sato
Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses.
The American journal of pathology 2007;170(5):1649-58.
2007: Rieko Izumi; Manabu Fujimoto; Norihito Yazawa; Hiroko Nakashima; Nobuko Asashima; Rei Watanabe; Yoshihiro Kuwano; Mineo Kurokawa; Takashi Hashimoto; Kunihiko Tamaki
Bullous pemphigoid positive for anti-BP180 and anti-laminin 5 antibodies in a patient with graft-vs-host disease.
Journal of the American Academy of Dermatology 2007;56(5 Suppl):S94-7.
2007: Takashi Matsushita; Minoru Hasegawa; Manabu Fujimoto; Yasuhito Hamaguchi; Kazuhiro Komura; Takashi Hirano; Mayuka Horikawa; Miki Kondo; Hidemitsu Orito; Kenzo Kaji; Yuki Saito; Yukiyo Matsushita; Shigeru Kawara; Masahide Yasui; Mariko Seishima; Shoichi Ozaki; Masataka Kuwana; Fumihide Ogawa; Shinichi Sato; Kazuhiko Takehara
Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis.
The Journal of rheumatology 2007;34(5):1012-8.
2007: Hidemitsu Orito; Manabu Fujimoto; Nobuko Ishiura; Koichi Yanaba; Takashi Matsushita; Minoru Hasegawa; Fumihide Ogawa; Kazuhiko Takehara; Shinichi Sato
Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction.
Journal of leukocyte biology 2007;81(5):1197-204.
2007: Rei Watanabe; Manabu Fujimoto; Norihito Yazawa; Hiroko Nakashima; Nobuko Asashima; Yoshihiro Kuwano; Yusuke Tada; N Maruyama; Hitoshi Okochi; Kunihiko Tamaki
Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid.
Journal of dermatological science 2007;46(1):53-60.
2007: Manabu Fujimoto; Shinichi Sato
B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity.
Journal of dermatological science 2007;46(1):1-9.
2007: Y Hitomi; Naoyuki Tsuchiya; M Hasegawa; Manabu Fujimoto; Kazuhiko Takehara; Katsushi Tokunaga; Shinichi Sato
Association of CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis.
Tissue antigens 2007;69(3):242-9.
2007: Hiroko Nakashima; Manabu Fujimoto; Nobuko Asashima; Rei Watanabe; Yoshihiro Kuwano; Norihito Yazawa; N Maruyama; Hitoshi Okochi; Atsushi Kumanogoh; Kunihiko Tamaki
Serum chemokine profile in patients with bullous pemphigoid.
The British journal of dermatology 2007;156(3):454-9.
2007: Yoshihiro Kuwano; Manabu Fujimoto; Rei Watanabe; Nobuko Asashima; Hiroko Nakashima; Hiroki Ohno; Shoichiro Yano; Norihito Yazawa; Hitoshi Okochi; Kunihiko Tamaki
Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata.
Archives of dermatological research 2007;298(10):493-8.
2007: Kazuhiro Komura; Manabu Fujimoto; Takashi Matsushita; Koichi Yanaba; Masanari Kodera; Ayako Kawasuji; Minoru Hasegawa; Kazuhiko Takehara; Shinichi Sato
Increased serum soluble CD40 levels in patients with systemic sclerosis.
The Journal of rheumatology 2007;34(2):353-8.
2007: Rei Watanabe; Nobuko Ishiura; Hiroko Nakashima; Norihito Yazawa; Yoshihiro Kuwano; Yusuke Tada; Hitoshi Okochi; Manabu Fujimoto; Kunihiko Tamaki
Increased serum levels of circulating CD40 ligand in patients with bullous pemphigoid: preliminary results.
Dermatology (Basel, Switzerland) 2007;215(3):180-6.
2007: Kenzo Kaji; Manabu Fujimoto; Minoru Hasegawa; Miki Kondo; Yuki Saito; Kazuhiro Komura; Takashi Matsushita; Hidemitsu Orito; Yasuhito Hamaguchi; Koichi Yanaba; M Itoh; Y Asano; Mariko Seishima; Fumihide Ogawa; Shinichi Sato; Kazuhiko Takehara
Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy.
Rheumatology (Oxford, England) 2007;46(1):25-8.
2006: Minoru Hasegawa; Yasuhito Hamaguchi; Koichi Yanaba; Jean-David Bouaziz; Junji Uchida; Manabu Fujimoto; Takashi Matsushita; Yukiyo Matsushita; Mayuka Horikawa; Kazuhiro Komura; Kazuhiko Takehara; Shinichi Sato; Thomas F Tedder
B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis.
The American journal of pathology 2006;169(3):954-66.
2006: Mayuka Horikawa; Manabu Fujimoto; Minoru Hasegawa; Takashi Matsushita; Yasuhito Hamaguchi; Ayako Kawasuji; Yukiyo Matsushita; Tomoyuki Fujita; Fumihide Ogawa; Kazuhiko Takehara; Douglas A Steeber; Shinichi Sato
E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis.
The American journal of pathology 2006;169(3):740-9.
2006: Hiroko Nakashima; Mayumi Komine; Kiyo Sasaki; Hiroshi Mitsui; Manabu Fujimoto; Hironobu Ihn; Akihiko Asahina; Kanako Kikuchi; Kunihiko Tamaki
Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome.
The Journal of dermatology 2006;33(8):557-62.
2006: Nobuko Asashima; Manabu Fujimoto; Rei Watanabe; Hiroko Nakashima; Norihito Yazawa; Hitoshi Okochi; Kunihiko Tamaki
Serum levels of BAFF are increased in bullous pemphigoid but not in pemphigus vulgaris.
The British journal of dermatology 2006;155(2):330-6.
2006: Naoki Mugii; Minoru Hasegawa; Takashi Matsushita; Miki Kondo; Hidemitsu Orito; Koichi Yanaba; Kazuhiro Komura; Ikuko Hayakawa; Yasuhito Hamaguchi; Munehiro Ikuta; Katsuhiko Tachino; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
The efficacy of self-administered stretching for finger joint motion in Japanese patients with systemic sclerosis.
The Journal of rheumatology 2006;33(8):1586-92.
2006: Shoichiro Yano; Mayumi Komine; Manabu Fujimoto; Hitoshi Okochi; Kunihiko Tamaki
Activation of Akt by mechanical stretching in human epidermal keratinocytes.
Experimental dermatology 2006;15(5):356-61.
2006: Ayako Kawasuji; Minoru Hasegawa; Mayuka Horikawa; Tomoyuki Fujita; Yukiyo Matsushita; Takashi Matsushita; Manabu Fujimoto; Douglas A Steeber; Thomas F Tedder; Kazuhiko Takehara; Shinichi Sato
L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury.
Journal of leukocyte biology 2006;79(4):696-705.
2006: Takashi Matsushita; Manabu Fujimoto; Minoru Hasegawa; Kazuhiro Komura; Kazuhiko Takehara; Thomas F Tedder; Shinichi Sato
Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response.
The American journal of pathology 2006;168(3):812-21.
2006: Manabu Fujimoto; Yoshihiro Kuwano; Rei Watanabe; Nobuko Asashima; Hiroko Nakashima; Satoko Yoshitake; Hitoshi Okochi; Kunihiko Tamaki; Jonathan C Poe; Thomas F Tedder; Shinichi Sato
B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):873-9.
2006: Manabu Fujimoto; Minoru Hasegawa; Y Hamaguchi; Kazuhiro Komura; Takashi Matsushita; Koichi Yanaba; Masanari Kodera; Kazuhiko Takehara; Shinichi Sato
A clue for telangiectasis in systemic sclerosis: elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease.
Dermatology (Basel, Switzerland) 2006;213(2):88-92.
2006: Minoru Hasegawa; Manabu Fujimoto; Ikuko Hayakawa; Takashi Matsushita; Chihiro Nishijima; Masahide Yamazaki; Kazuhiko Takehara; Shinichi Sato
Anti-phosphatidylserine-prothrombin complex antibodies in patients with localized scleroderma.
Clinical and experimental rheumatology 2006;24(1):19-24.
2005: Kazuhiro Komura; Manabu Fujimoto; Takashi Matsushita; Kenzo Kaji; Miki Kondo; Takashi Hirano; Hidemitsu Orito; Mayuka Horikawa; Yasuhito Hamaguchi; Minoru Hasegawa; Kazuhiko Takehara; Shinichi Sato
Prevalence and clinical characteristics of anti-Mi-2 antibodies in Japanese patients with dermatomyositis.
Journal of dermatological science 2005;40(3):215-7.
2005: Manabu Fujimoto; Shinichi Sato
B lymphocytes and systemic sclerosis.
Current opinion in rheumatology 2005;17(6):746-51.
2005: Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis.
Journal of dermatological science 2005;39(1):1-7.
2005: Hiroko Nakashima; K Yamane; Hironobu Ihn; Kozo Nakamura; Rei Watanabe; Yoshihiro Kuwano; Tomonori Takekoshi; T Watanabe; Naoko Hattori; Manabu Fujimoto; Kunihiko Tamaki
Drug-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and increase in serum IgE level.
Dermatology (Basel, Switzerland) 2005;210(4):349-52.
2005: Thomas F Tedder; Jonathan C Poe; Manabu Fujimoto; Karen M Haas; Shinichi Sato
The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.
Current directions in autoimmunity 2005;8():55-90.
2004: Shinichi Sato; Masanari Kodera; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara
Antinucleosome antibody is a major autoantibody in localized scleroderma.
The British journal of dermatology 2004;151(6):1182-8.
2004: Naoyuki Tsuchiya; Kimiko Kuroki; Manabu Fujimoto; Yoshinori Murakami; Thomas F Tedder; Katsushi Tokunaga; Kazuhiko Takehara; Shinichi Sato
Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis.
Arthritis and rheumatism 2004;50(12):4002-7.
2004: Shinichi Sato; Manabu Fujimoto; Minoru Hasegawa; Kazuhiko Takehara; Thomas F Tedder
Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis.
Molecular immunology 2004;41(12):1123-33.
2004: Nobuko Asashima; Manabu Fujimoto; Masatoshi Jinnin; Hironobu Ihn; Kanako Kikuchi; Masaru Takamizawa; Kunihiko Tamaki
[A female case of hyper-IgM immunodeficiency syndrome with uncommon skin manifestations].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2004;27(5):350-5.
2004: Jonathan C Poe; Yoko Fujimoto; Minoru Hasegawa; Karen M Haas; Ann S Miller; Isaac G Sanford; Cheryl B Bock; Manabu Fujimoto; Thomas F Tedder
CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms.
Nature immunology 2004;5(10):1078-87.
2004: Shinichi Sato; Manabu Fujimoto; Minoru Hasegawa; Kazuhiro Komura; Koichi Yanaba; Ikuko Hayakawa; Takashi Matsushita; Kazuhiko Takehara
Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis.
Rheumatology (Oxford, England) 2004;43(10):1261-6.
2004: Shinichi Sato; Manabu Fujimoto; Minoru Hasegawa; Kazukiko Takehara
Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells.
Arthritis and rheumatism 2004;50(6):1918-27.
2004: Shoichiro Yano; Mayumi Komine; Manabu Fujimoto; Hitoshi Okochi; Kunihiko Tamaki
Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes.
The Journal of investigative dermatology 2004;122(3):783-90.
2004: Kazuhiro Komura; Shinichi Sato; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara
Elevated circulating CD40L concentrations in patients with systemic sclerosis.
The Journal of rheumatology 2004;31(3):514-9.
2004: Jonathan C Poe; Karen M Haas; Junji Uchida; Youngkyun Lee; Manabu Fujimoto; Thomas F Tedder
Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2100-10.
2003: Shinichi Sato; Manabu Fujimoto; Minoru Hasegawa; Kazuhiko Takehara
Antiphospholipid antibody in localised scleroderma.
Annals of the rheumatic diseases 2003;62(8):771-4.
2003: Koichi Yanaba; Minoru Hasegawa; Y Hamaguchi; Manabu Fujimoto; Kazuhiko Takehara; Shinichi Sato
Longitudinal analysis of serum KL-6 levels in patients with systemic sclerosis: association with the activity of pulmonary fibrosis.
Clinical and experimental rheumatology 2003;21(4):429-36.
2003: Shinobu Furuse; Hidetaka Fujii; Yuko Kaburagi; Manabu Fujimoto; Minoru Hasegawa; Kazuhiko Takehara; Shinichi Sato
Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-alpha are elevated in patients with systemic sclerosis.
The Journal of rheumatology 2003;30(7):1524-8.
2003: Shinichi Sato; Ikuko Hayakawa; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara
Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis.
The Journal of investigative dermatology 2003;120(4):542-7.
2003: Shoichiro Yano; Mayumi Komine; Manabu Fujimoto; Hitoshi Okochi; Kunihiko Tamaki
Interleukin 15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line, HaCaT.
Biochemical and biophysical research communications 2003;301(4):841-7.
2003: Minoru Hasegawa; Shinichi Sato; Tetsuya Nagaoka; Manabu Fujimoto; Kazuhiko Takehara
Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma.
Dermatology (Basel, Switzerland) 2003;207(2):141-7.
2002: Hironobu Ihn; Yoshihide Asano; Masahide Kubo; Kenichi Yamane; Masatoshi Jinnin; Norihito Yazawa; Manabu Fujimoto; Kunihiko Tamaki
Clinical significance of serum surfactant protein D (SP-D) in patients with polymyositis/dermatomyositis: correlation with interstitial lung disease.
Rheumatology (Oxford, England) 2002;41(11):1268-72.
2002: Kazuhiro Komura; Shinichi Sato; Manabu Fujimoto; Minoru Hasegawa; Kazuhiko Takehara
Elevated levels of circulating CD44 in patients with systemic sclerosis: association with a milder subset.
Rheumatology (Oxford, England) 2002;41(10):1149-54.
2002: Eriko Saito; Manabu Fujimoto; Minoru Hasegawa; Kazuhiro Komura; Yasuhito Hamaguchi; Yuko Kaburagi; Tetsuya Nagaoka; Kazuhiko Takehara; Thomas F Tedder; Shinichi Sato
CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.
The Journal of clinical investigation 2002;109(11):1453-62.
2002: Manabu Fujimoto; Jonathan C Poe; Anne B Satterthwaite; Matthew I Wahl; Owen N Witte; Thomas F Tedder
Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5465-76.
2002: Yoko Fujimoto; LiLi Tu; Ann S Miller; Cheryl Bock; Manabu Fujimoto; Carolyn Doyle; Douglas A Steeber; Thomas F Tedder
CD83 expression influences CD4+ T cell development in the thymus.
Cell 2002;108(6):755-67.
2001: Manabu Fujimoto; Jonathan C Poe; Minoru Hasegawa; Thomas F Tedder
CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
The Journal of biological chemistry 2001;276(48):44820-7.
2001: Shinichi Sato; Kazuhiro Komura; Minoru Hasegawa; Manabu Fujimoto; Kazuhiko Takehara
Clinical significance of soluble CD31 in patients with systemic sclerosis (SSc): association with limited cutaneous SSc.
The Journal of rheumatology 2001;28(11):2460-5.
2001: Minoru Hasegawa; Manabu Fujimoto; Jonathan C Poe; Douglas A Steeber; Thomas F Tedder
CD19 can regulate B lymphocyte signal transduction independent of complement activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3190-200.
2001: Minoru Hasegawa; Manabu Fujimoto; Jonathan C Poe; Douglas A Steeber; C A Lowell; Thomas F Tedder
A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2469-78.
2001: Yoshihide Asano; Hironobu Ihn; Kenichi Yamane; Norihito Yazawa; Masahide Kubo; Manabu Fujimoto; Kunihiko Tamaki
Clinical significance of surfactant protein D as a serum marker for evaluating pulmonary fibrosis in patients with systemic sclerosis.
Arthritis and rheumatism 2001;44(6):1363-9.
2000: Patricia A Zipfel; Matthew Grove; Kevin Blackburn; Manabu Fujimoto; Thomas F Tedder; Ann Marie Pendergast
The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):6872-9.
2000: Shinichi Sato; Minoru Hasegawa; Manabu Fujimoto; Thomas F Tedder; Kazuhiko Takehara
Quantitative genetic variation in CD19 expression correlates with autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6635-43.
2000: Manabu Fujimoto; Yoko Fujimoto; Jonathan C Poe; Paul J Jansen; C A Lowell; A L DeFranco; Thomas F Tedder
CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
Immunity 2000;13(1):47-57.
2000: Jonathan C Poe; Manabu Fujimoto; Paul J Jansen; Ann S Miller; Thomas F Tedder
CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
The Journal of biological chemistry 2000;275(23):17420-7.
2000: Thomas F Tedder; Shinichi Sato; Jonathan C Poe; Manabu Fujimoto
CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity.
The Keio journal of medicine 2000;49(1):1-13.
2000: Hironobu Ihn; Norihito Yazawa; Masahide Kubo; Kenichi Yamane; Shinichi Sato; Manabu Fujimoto; Kanako Kikuchi; Y Soma; Kunihiko Tamaki
Circulating levels of soluble CD30 are increased in patients with localized scleroderma and correlated with serological and clinical features of the disease.
The Journal of rheumatology 2000;27(3):698-702.
2000: Manabu Fujimoto; Jonathan C Poe; Minoru Hasegawa; Thomas F Tedder
CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification.
Immunologic research 2000;22(2-3):281-98.
2000: Norihito Yazawa; Kanako Kikuchi; Hironobu Ihn; Manabu Fujimoto; Masahide Kubo; T Tamaki; Kunihiko Tamaki
Serum levels of tissue inhibitor of metalloproteinases 2 in patients with systemic sclerosis.
Journal of the American Academy of Dermatology 2000;42(1 Pt 1):70-5.
1999: Manabu Fujimoto; Alice Bradney; Jonathan C Poe; Douglas A Steeber; Thomas F Tedder
Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
Immunity 1999;11(2):191-200.
1999: Manabu Fujimoto; Jonathan C Poe; Paul J Jansen; Shinichi Sato; Thomas F Tedder
CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7088-94.
1998: Hironobu Ihn; Shinichi Sato; Manabu Fujimoto; K Takehara; Kunihiko Tamaki
Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis.
British journal of rheumatology 1998;37(11):1188-92.
1998: Masahide Kubo; Kanako Kikuchi; Norihito Yazawa; Manabu Fujimoto; T Tamaki; Kunihiko Tamaki
Increased serum concentration of hyaluronate in dermatomyositis patients.
Archives of dermatological research 1998;290(10):579-81.
1998: Manabu Fujimoto; Jonathan C Poe; M Inaoki; Thomas F Tedder
CD19 regulates B lymphocyte responses to transmembrane signals.
Seminars in immunology 1998;10(4):267-77.
1998: Masahide Kubo; Kanako Kikuchi; Manabu Fujimoto; Kunihiko Tamaki
Serum concentrations of carboxyterminal propeptide of type 1 procollogen and tissue inhibitor of metalloproteinase 1 in patients with dermatomyositis.
Archives of dermatological research 1998;290(5):253-7.
1998: Norihito Yazawa; Manabu Fujimoto; Kanako Kikuchi; Masahide Kubo; Hironobu Ihn; Shinichi Sato; T Tamaki; Kunihiko Tamaki
High seroprevalence of Helicobacter pylori infection in patients with systemic sclerosis: association with esophageal involvement.
The Journal of rheumatology 1998;25(4):650-3.
1998: Minoru Hasegawa; Shinichi Sato; Manabu Fujimoto; H Ihn; K Kikuchi; Kazuhiko Takehara
Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis.
The Journal of rheumatology 1998;25(2):308-13.
1997: Manabu Fujimoto; Kanako Kikuchi; T Tamaki; Norihito Yazawa; Masahide Kubo; Hironobu Ihn; Shinichi Sato; Y Soma; Kunihiko Tamaki
Distribution of anti-p80-coilin autoantibody in collagen diseases and various skin diseases.
The British journal of dermatology 1997;137(6):916-20.
1997: Hironobu Ihn; Shinichi Sato; Manabu Fujimoto; K Kikuchi; T Kadono; Kunihiko Tamaki; K Takehara
Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: enhancement by inflammatory cytokines.
British journal of rheumatology 1997;36(12):1270-5.
1997: Manabu Fujimoto; M Shimozuma; N Yazawa; M Kubo; Hironobu Ihn; Shinichi Sato; T Tamaki; K Kikuchi; Kunihiko Tamaki
Prevalence and clinical relevance of 52-kDa and 60-kDa Ro/SS-A autoantibodies in Japanese patients with systemic sclerosis.
Annals of the rheumatic diseases 1997;56(11):667-70.
1997: Minoru Hasegawa; Manabu Fujimoto; K Kikuchi; Kazuhiko Takehara
Elevated serum tumor necrosis factor-alpha levels in patients with systemic sclerosis: association with pulmonary fibrosis.
The Journal of rheumatology 1997;24(4):663-5.
1997: Minoru Hasegawa; Manabu Fujimoto; K Kikuchi; Kazuhiko Takehara
Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis.
The Journal of rheumatology 1997;24(2):328-32.
1996: H Ihn; Shinichi Sato; Manabu Fujimoto; K Kikuchi; A Igarashi; Y Soma; Kunihiko Tamaki; K Takehara
Measurement of anticardiolipin antibodies by ELISA using beta 2-glycoprotein I (beta 2-GPI) in systemic sclerosis.
Clinical and experimental immunology 1996;105(3):475-9.
1996: T Kadono; K Kikuchi; Masahide Kubo; Manabu Fujimoto; Kunihiko Tamaki
Serum concentrations of basic fibroblast growth factor in collagen diseases.
Journal of the American Academy of Dermatology 1996;35(3 Pt 1):392-7.
1996: Manabu Fujimoto; Shinichi Sato; H Ihn; T Tamaki; K Kikuchi; Y Soma; Kunihiko Tamaki
Autoantibodies to mitochondrial 2-oxo-acid dehydrogenase complexes in localized scleroderma.
Clinical and experimental immunology 1996;105(2):297-301.
1996: Shinichi Sato; Manabu Fujimoto; K Kikuchi; H Ihn; Kunihiko Tamaki; K Takehara
Soluble CD4 and CD8 in serum from patients with localized scleroderma.
Archives of dermatological research 1996;288(7):358-62.
1996: Manabu Fujimoto; Shinichi Sato; H Ihn; K Kikuchi; T Tamaki; Kunihiko Tamaki; K Takehara
Antiubiquitin antibody in localised and systemic scleroderma.
Annals of the rheumatic diseases 1996;55(6):399-402.
1996: H Ihn; Shinichi Sato; Manabu Fujimoto; K Kikuchi; K Takehara
Clinical significance of serum levels of soluble interleukin-2 receptor in patients with localized scleroderma.
The British journal of dermatology 1996;134(5):843-7.
1996: Shinichi Sato; Manabu Fujimoto; K Kikuchi; H Ihn; Kunihiko Tamaki; K Takehara
Elevated soluble CD23 levels in the sera from patients with localized scleroderma.
Archives of dermatological research 1996;288(2):74-8.
1996: Manabu Fujimoto; Shinichi Sato; N Hayashi; M Wakugawa; T Tsuchida; Kunihiko Tamaki
Juvenile temporal arteritis with eosinophilia: a distinct clinicopathological entity.
Dermatology (Basel, Switzerland) 1996;192(1):32-5.
1995: K Kikuchi; Masahide Kubo; Shinichi Sato; Manabu Fujimoto; Kunihiko Tamaki
Serum tissue inhibitor of metalloproteinases in patients with systemic sclerosis.
Journal of the American Academy of Dermatology 1995;33(6):973-8.
1995: Manabu Fujimoto; Shinichi Sato; K Takehara; Y Nojima; Y Soma; K Kikuchi; H Ihn; A Igarashi; Kunihiko Tamaki
Detection of antiribosomal P protein antibodies in patients with systemic sclerosis.
British journal of rheumatology 1995;34(10):908-11.
1995: Manabu Fujimoto; Shinichi Sato; H Ihn; K Kikuchi; Kunihiko Tamaki; K Takehara
Autoantibodies to pyruvate dehydrogenase complex in patients with systemic sclerosis. Possible role of anti-E1 alpha antibody as a serologic indicator for development of primary biliary cirrhosis.
Arthritis and rheumatism 1995;38(7):985-9.
1995: H Ihn; M Shimozuma; Manabu Fujimoto; Shinichi Sato; K Kikuchi; A Igarashi; Y Soma; Kunihiko Tamaki; K Takehara
Ultrasound measurement of skin thickness in systemic sclerosis.
British journal of rheumatology 1995;34(6):535-8.
1995: Manabu Fujimoto; Shinichi Sato; H Ihn; K Kikuchi; N Yamada; K Takehara
Serum aldolase level is a useful indicator of disease activity in eosinophilic fasciitis.
The Journal of rheumatology 1995;22(3):563-5.
1995: H Ihn; Shinichi Sato; Manabu Fujimoto; K Kikuchi; K Takehara
Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma.
Archives of dermatological research 1995;287(2):193-7.
1995: K Kikuchi; T Kadono; Manabu Fujimoto; H Ihn; Shinichi Sato; K Takehara
Elevated procollagen type I carboxyterminal propeptide production in cultured scleroderma fibroblasts.
Dermatology (Basel, Switzerland) 1995;190(2):104-8.
1995: Manabu Fujimoto; Shinichi Sato; H Ihn; K Takehara
Autoantibodies to the heat-shock protein hsp73 in localized scleroderma.
Archives of dermatological research 1995;287(6):581-5.
1994: Shinichi Sato; Manabu Fujimoto; H Ihn; K Kikuchi; K Takehara
Clinical characteristics associated with antihistone antibodies in patients with localized scleroderma.
Journal of the American Academy of Dermatology 1994;31(4):567-71.
1994: H Ihn; Manabu Fujimoto; Shinichi Sato; K Kikuchi; A Igarashi; Y Soma; K Takehara
Increased levels of circulating intercellular adhesion molecule-1 in patients with localized scleroderma.
Journal of the American Academy of Dermatology 1994;31(4):591-5.
1994: Shinichi Sato; Manabu Fujimoto; H Ihn; K Kikuchi; K Takehara
Antigen specificity of antihistone antibodies in localized scleroderma.
Archives of dermatology 1994;130(10):1273-7.
1994: Shinichi Sato; Manabu Fujimoto; H Ihn; K Takehara
Antibodies to centromere and centriole in scleroderma spectrum disorders.
Dermatology (Basel, Switzerland) 1994;189(1):23-6.
1993: K Kikuchi; Y Soma; Manabu Fujimoto; T Kadono; Shinichi Sato; M Abe; K Ohhara; K Takehara
Dermatofibrosarcoma protuberans: increased growth response to platelet-derived growth factor BB in cell culture.
Biochemical and biophysical research communications 1993;196(1):409-415.