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Shimpei Fujimoto

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Shin-ichi Harashima; Shimpei Fujimoto; Toru Fukushima; Akihiro Hamasaki; Norio Harada; Kazuaki Nagashima; Yuko Nakahigashi; Yuichi Nishi; Masahito Ogura; Mayumi Sasaki; Yutaka Seino; Daisuke Tanaka; Shunsuke Yamane; Nobuya Inagaki
Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study).
Kaori Ikeda; Shimpei Fujimoto; Masashi Goto; Akihiro Hamasaki; Takashi Kawamura; Kenichiro Shide; Chizumi Yamada; Nobuya Inagaki
Impact of endogenous and exogenous insulin on basal energy expenditure in patients with type 2 diabetes under standard treatment.
Shimpei Fujimoto; Eri Mukai; Nobuya Inagaki
Role of endogenous ROS production in impaired metabolism-secretion coupling of diabetic pancreatic β cells.

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2013: Shin-ichi Harashima; Shimpei Fujimoto; Toru Fukushima; Akihiro Hamasaki; Norio Harada; Kazuaki Nagashima; Yuko Nakahigashi; Yuichi Nishi; Masahito Ogura; Mayumi Sasaki; Yutaka Seino; Daisuke Tanaka; Shunsuke Yamane; Nobuya Inagaki
Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study).
Diabetes/metabolism research and reviews 2013;29(1):77-84.
2011: Kaori Ikeda; Shimpei Fujimoto; Masashi Goto; Akihiro Hamasaki; Takashi Kawamura; Kenichiro Shide; Chizumi Yamada; Nobuya Inagaki
Impact of endogenous and exogenous insulin on basal energy expenditure in patients with type 2 diabetes under standard treatment.
The American journal of clinical nutrition 2011;94(6):1513-8.
2011: Shimpei Fujimoto; Eri Mukai; Nobuya Inagaki
Role of endogenous ROS production in impaired metabolism-secretion coupling of diabetic pancreatic β cells.
Progress in biophysics and molecular biology 2011;107(2):304-10.
2011: Eri Mukai; Shimpei Fujimoto; Nobuya Inagaki
[Severe hypoglycemia by combination therapy with dipeptidyl peptidase-4 (DPP-4) inhibitors and sulfonylureas].
Nihon rinsho. Japanese journal of clinical medicine 2011;69(5):907-11.
2011: Yuichi Nishi; Mayumi Sasaki; Hiroki Sato; Yuichi Sato; Yumiko Tahara; Shimpei Fujimoto; Eri Mukai; Yasuhiko Nakamura; Nobuya Inagaki
Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1.
The Biochemical journal 2011;435(2):421-30.
2011: Eiichi Ogawa; Masaya Hosokawa; Norio Harada; Shunsuke Yamane; Akihiro Hamasaki; Kentaro Toyoda; Shimpei Fujimoto; Yoshihito Fujita; Kazuhito Fukuda; Katsushi Tsukiyama; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice.
Biochemical and biophysical research communications 2011;404(1):115-20.
2011: Eri Mukai; Shimpei Fujimoto; Hiroki Sato; Chitose Oneyama; Rieko Kominato; Yuichi Sato; Mayumi Sasaki; Yuichi Nishi; Masato Okada; Nobuya Inagaki
Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.
Diabetes 2011;60(1):218-26.
2010: Shimpei Fujimoto; Nobuya Inagaki; Yutaka Seino
[Pancreatic polypeptide (PP)].
Nihon rinsho. Japanese journal of clinical medicine 2010;68 Suppl 7():560-2.
2010: Y Fujita; M Hosokawa; Shimpei Fujimoto; Eri Mukai; A Abudukadier; A Obara; M Ogura; Yasuyuki Nakamura; K Toyoda; K Nagashima; Yutaka Seino; Nobuya Inagaki
Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice.
Diabetologia 2010;53(7):1472-81.
2010: Kana Toyama; Atsushi Yonezawa; Masahiro Tsuda; Satohiro Masuda; Ikuko Yano; Tomohiro Terada; Riyo Osawa; Toshiya Katsura; Masaya Hosokawa; Shimpei Fujimoto; Nobuya Inagaki; Ken-Ichi Inui
Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.
Pharmacogenetics and genomics 2010;20(2):135-8.
2010: Makiko Shimodahira; Shimpei Fujimoto; Eri Mukai; Yasuhiko Nakamura; Yuichi Nishi; Mayumi Sasaki; Yuichi Sato; Hiroki Sato; Masaya Hosokawa; Kazuaki Nagashima; Yutaka Seino; Nobuya Inagaki
Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism.
The Journal of endocrinology 2010;204(1):37-46.
2008: Shogo Funakoshi; Shimpei Fujimoto; Akihiro Hamasaki; Hideya Fujiwara; Yoshihito Fujita; Kaori Ikeda; Yoshiyuki Hamamoto; Masaya Hosokawa; Yutaka Seino; Nobuya Inagaki
Analysis of factors influencing pancreatic beta-cell function in Japanese patients with type 2 diabetes: association with body mass index and duration of diabetic exposure.
Diabetes research and clinical practice 2008;82(3):353-8.
2008: Mariko Sassa; Yuichiro Yamada; Masaya Hosokawa; Kazuhito Fukuda; Shimpei Fujimoto; Kentaro Toyoda; Katsushi Tsukiyama; Yutaka Seino; Nobuya Inagaki
Glycemic instability in type 1 diabetic patients: Possible role of ketosis or ketoacidosis at onset of diabetes.
Diabetes research and clinical practice 2008;81(2):190-5.
2008: Rieko Kominato; Shimpei Fujimoto; Eri Mukai; Yasuyuki Nakamura; Koichiro Nabe; Makiko Shimodahira; Yuichi Nishi; Shogo Funakoshi; Yutaka Seino; Nobuya Inagaki
Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets.
Diabetologia 2008;51(7):1226-35.
2008: Hideya Fujiwara; Masaya Hosokawa; Xiaorong Zhou; Shimpei Fujimoto; Kazuhito Fukuda; Kentaro Toyoda; Yuichi Nishi; Yoshihito Fujita; Kotaro Yamada; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Curcumin inhibits glucose production in isolated mice hepatocytes.
Diabetes research and clinical practice 2008;80(2):185-91.
2008: Kotaro Yamada; Masaya Hosokawa; Chizumi Yamada; Rie Watanabe; Shimpei Fujimoto; Hideya Fujiwara; Masaru Kunitomo; Toshihiro Miura; Tetsuo Kaneko; Kinsuke Tsuda; Yutaka Seino; Nobuya Inagaki
Dietary corosolic acid ameliorates obesity and hepatic steatosis in KK-Ay mice.
Biological & pharmaceutical bulletin 2008;31(4):651-5.
2008: Kotaro Yamada; Masaya Hosokawa; Shimpei Fujimoto; Hideya Fujiwara; Yoshihito Fujita; Norio Harada; Chizumi Yamada; Mitsuo Fukushima; Naoya Ueda; Tetsuo Kaneko; Futoshi Matsuyama; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Effect of corosolic acid on gluconeogenesis in rat liver.
Diabetes research and clinical practice 2008;80(1):48-55.
2007: Shimpei Fujimoto; Koichiro Nabe; Mihoko Takehiro; Makiko Shimodahira; Mariko Kajikawa; Tomomi Takeda; Eri Mukai; Nobuya Inagaki; Yutaka Seino
Impaired metabolism-secretion coupling in pancreatic beta-cells: role of determinants of mitochondrial ATP production.
Diabetes research and clinical practice 2007;77 Suppl 1():S2-10.
2007: Akihiro Hamasaki; Yuichiro Yamada; Takeshi Kurose; Nobuhiro Ban; Kazuaki Nagashima; Akira Takahashi; Shimpei Fujimoto; Dai Shimono; Michio Fujiwara; Shinya Toyokuni; Yutaka Seino; Nobuya Inagaki
Adult pancreatic islets require differential pax6 gene dosage.
Biochemical and biophysical research communications 2007;353(1):40-6.
2007: Kotaro Yamada; Masaya Hosokawa; Shimpei Fujimoto; Kazuaki Nagashima; Kazuhito Fukuda; Hideya Fujiwara; Eiichi Ogawa; Yoshihito Fujita; Naoya Ueda; Futoshi Matsuyama; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
The spontaneously diabetic Torii rat with gastroenteropathy.
Diabetes research and clinical practice 2007;75(2):127-34.
2007: Shimpei Fujimoto; Hiroshi Katsuki; M Ohnishi; M Takagi; Toshiaki Kume; Akinori Akaike
Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo.
Neuroscience 2007;144(2):694-701.
2006: Yuichiro Yamada; Kazuhito Fukuda; Shimpei Fujimoto; Masaya Hosokawa; Katsushi Tsukiyama; Kazuaki Nagashima; Mitsuo Fukushima; Haruhiko Suzuki; Kentaro Toyoda; Mariko Sassa; Shogo Funakoshi; Nobuya Inagaki; Ataru Taniguchi; T Shun Sato; Shinichi Matsumoto; Koichi Tanaka; Yutaka Seino
SUIT, secretory units of islets in transplantation: An index for therapeutic management of islet transplanted patients and its application to type 2 diabetes.
Diabetes research and clinical practice 2006;74(3):222-6.
2006: Mariko Sassa; Kazuhito Fukuda; Shimpei Fujimoto; Kentaro Toyoda; Yoshihito Fujita; Shinichi Matsumoto; Teru Okitsu; Yasuhiro Iwanaga; Hirofumi Noguchi; Hideo Nagata; Yukihide Yonekawa; Takeshi Ohara; Masahiko Okamoto; Koichi Tanaka; Yutaka Seino; Nobuya Inagaki; Yuichiro Yamada
A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement.
Diabetes research and clinical practice 2006;73(3):235-40.
2006: Koichiro Nabe; Shimpei Fujimoto; Makiko Shimodahira; Rieko Kominato; Yuichi Nishi; Shogo Funakoshi; Eri Mukai; Yuichiro Yamada; Yutaka Seino; Nobuya Inagaki
Diphenylhydantoin suppresses glucose-induced insulin release by decreasing cytoplasmic H+ concentration in pancreatic islets.
Endocrinology 2006;147(6):2717-27.
2005: Dai Shimono; Shimpei Fujimoto; Eri Mukai; Mihoko Takehiro; Koichiro Nabe; Razvan Gheorghe Radu; Makiko Shimodahira; Rieko Kominato; Yo Aramaki; Yuichi Nishi; Shogo Funakoshi; Yuichiro Yamada; Yutaka Seino
ATP enhances exocytosis of insulin secretory granules in pancreatic islets under Ca2+-depleted condition.
Diabetes research and clinical practice 2005;69(3):216-23.
2005: Mihoko Takehiro; Shimpei Fujimoto; Makiko Shimodahira; Dai Shimono; Eri Mukai; Koichiro Nabe; Razvan Gheorghe Radu; Rieko Kominato; Yo Aramaki; Yutaka Seino; Yuichiro Yamada
Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.
American journal of physiology. Endocrinology and metabolism 2005;288(2):E372-80.
2005: Razvan Gheorghe Radu; Shimpei Fujimoto; Eri Mukai; Mihoko Takehiro; Dai Shimono; Koichiro Nabe; Makiko Shimodahira; Rieko Kominato; Yo Aramaki; Yuichi Nishi; Shogo Funakoshi; Yuichiro Yamada; Yutaka Seino
Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.
American journal of physiology. Endocrinology and metabolism 2005;288(2):E365-71.
2004: Katsushi Tsukiyama; Yuichiro Yamada; Kazumasa Miyawaki; Akihiro Hamasaki; Kazuaki Nagashima; Masaya Hosokawa; Shimpei Fujimoto; Akira Takahashi; Kentaro Toyoda; Shinya Toyokuni; Yutaka Oiso; Yutaka Seino
Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(3):407-12.
2003: M Oya; Masaya Hosokawa; H Tsukada; Kazuhito Fukuda; H Nakamura; Katsushi Tsukiyama; Kazuaki Nagashima; Shimpei Fujimoto; Yuichiro Yamada; Yutaka Seino
Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats.
Diabetes research and clinical practice 2003;62(2):69-77.
2003: Yoshiyuki Hamamoto; Shimpei Fujimoto; Akari Inada; Mihoko Takehiro; Koichiro Nabe; Dai Shimono; Mariko Kajikawa; Jun Fujita; Yuichiro Yamada; Yutaka Seino
Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantation.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(8):460-5.
2003: Shimpei Fujimoto; Aki Matsushima; Kazuyasu Yoshitani; Michihiro Oya; Dai Shimono; Tomomi Takeda; Takeshi Kurose; Yuichiro Yamada; Yutaka Seino
Type-1 diabetes mellitus with insufficient serum immunoreactive insulin elevation after subcutaneous NPH-insulin injection.
Diabetes research and clinical practice 2003;60(1):69-73.
2002: Shimpei Fujimoto
[Structure and mechanisms of action of biguanides].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():377-81.
2002: Mariko Kajikawa; Shimpei Fujimoto; Yoshiyuki Tsuura; Eri Mukai; Tomomi Takeda; Yoshiyuki Hamamoto; Mihoko Takehiro; Jun Fujita; Yuichiro Yamada; Yutaka Seino
Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets.
Diabetes 2002;51(8):2522-9.
2002: Shimpei Fujimoto
[Neurohormonal regulation of insulin secretion].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():208-12.
2002: Kazumasa Miyawaki; Yuichiro Yamada; Nobuhiro Ban; Yu Ihara; Katsushi Tsukiyama; Heying Zhou; Shimpei Fujimoto; Akira Oku; Kinsuke Tsuda; Shinya Toyokuni; Hiroshi Hiai; Wataru Mizunoya; Tohru Fushiki; Jens Juul Holst; Mitsuhiro Makino; Akira Tashita; Yukari Kobara; Yoshiharu Tsubamoto; Takayoshi Jinnouchi; Takahito Jomori; Yutaka Seino
Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
Nature medicine 2002;8(7):738-42.
2002: Koichiro Yasuda; Yoshimasa Okamoto; Kumiko Nunoi; Tetsuya Adachi; Nobuyuki Shihara; Akiko Tamon; Naoko Suzuki; Eri Mukai; Shimpei Fujimoto; Akira Oku; Kinsuke Tsuda; Yutaka Seino
Normalization of cytoplasmic calcium response in pancreatic beta-cells of spontaneously diabetic GK rat by the treatment with T-1095, a specific inhibitor of renal Na+-glucose co-transporters.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(4):217-21.
2002: Shimpei Fujimoto; Eri Mukai; Yoshiyuki Hamamoto; Tomomi Takeda; Mihoko Takehiro; Yuichiro Yamada; Yutaka Seino
Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets.
Endocrinology 2002;143(1):213-21.
2001: Shun Shimohama; Hiroko Tanino; Shimpei Fujimoto
Differential expression of rat brain caspase family proteins during development and aging.
Biochemical and biophysical research communications 2001;289(5):1063-6.
2001: Shun Shimohama; Hiroko Tanino; Shimpei Fujimoto
Differential subcellular localization of caspase family proteins in the adult rat brain.
Neuroscience letters 2001;315(3):125-8.
2001: Hiroko Tanino; T Kusuda; Kazuki Nagasawa; Shun Shimohama; Shimpei Fujimoto
Alterations of phospholipase C isozymes in rat cerebral cortex through hyperoxia.
Biological & pharmaceutical bulletin 2001;24(11):1241-5.
2001: Yoshiyuki Hamamoto; Yoshiyuki Tsuura; Shimpei Fujimoto; M Nagata; Tomomi Takeda; Eri Mukai; Jun Fujita; Yuichiro Yamada; Yutaka Seino
Recovery of function and mass of endogenous beta-cells in streptozotocin-induced diabetic rats treated with islet transplantation.
Biochemical and biophysical research communications 2001;287(1):104-9.
2001: ZP Shen; M Nishimura; Yoshiyuki Tsuura; Shimpei Fujimoto; Eri Mukai; Yuichiro Yamada; Yutaka Seino
Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets.
Diabetes research and clinical practice 2001;53(1):9-16.
2001: Tomomi Takeda; Yoshiyuki Tsuura; Jun Fujita; Shimpei Fujimoto; Eri Mukai; Mariko Kajikawa; Yoshiyuki Hamamoto; Makoto Kume; Yoshie Yamamoto; Yoshio Yamaoka; Yuichiro Yamada; Yutaka Seino
Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets.
Biochemical and biophysical research communications 2001;284(1):20-5.
2001: Tomokatsu Ikawa; Shimpei Fujimoto; Hiroshi Kawamoto; Yoshimoto Katsura; Yoshifumi Yokota
Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5164-9.
2000: Shimpei Fujimoto; Yoshiyuki Tsuura; H Ishida; K Tsuji; Eri Mukai; Mariko Kajikawa; Yoshiyuki Hamamoto; Tomomi Takeda; Yuichiro Yamada; Yutaka Seino
Augmentation of basal insulin release from rat islets by preexposure to a high concentration of glucose.
American journal of physiology. Endocrinology and metabolism 2000;279(4):E927-40.
2000: N Kawakami; K Kita; T Hayakawa; T Yamaguchi; Shimpei Fujimoto
Phorbor myristate acetate induces NADPH oxidase activity of cytochalasin B-primed neutrophils through the protein kinase C-independent pathway.
Biological & pharmaceutical bulletin 2000;23(9):1100-4.
2000: Shun Shimohama; Hiroko Tanino; N Kawakami; N Okamura; H Kodama; T Yamaguchi; Takao Hayakawa; Akihiko Nunomura; S Chiba; George Perry; Mark A. Smith; Shimpei Fujimoto
Activation of NADPH oxidase in Alzheimer's disease brains.
Biochemical and biophysical research communications 2000;273(1):5-9.
2000: Hiroko Tanino; Shun Shimohama; Y Sasaki; Yoshio Sumida; Shimpei Fujimoto
Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains.
Biochemical and biophysical research communications 2000;271(3):620-5.
2000: T Iwakura; Shimpei Fujimoto; S Kagimoto; Akari Inada; A Kubota; Yoshimichi Someya; Yu Ihara; Yuichiro Yamada; Yutaka Seino
Sustained enhancement of Ca(2+) influx by glibenclamide induces apoptosis in RINm5F cells.
Biochemical and biophysical research communications 2000;271(2):422-8.
2000: Hiroshi Kawamoto; Tomokatsu Ikawa; Koichiro Ohmura; Shimpei Fujimoto; Yoshimoto Katsura
T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver.
Immunity 2000;12(4):441-50.
2000: Eri Mukai; H Ishida; Shimpei Fujimoto; Mariko Kajikawa; Yasuo Okamoto; Jun Fujita; Yoshiyuki Hamamoto; Yoshiyuki Tsuura; Yuichiro Yamada; N Furukawa; T Ohta; Yutaka Seino
The insulinotropic mechanism of the novel hypoglycaemic agent JTT-608: direct enhancement of Ca(2+) efficacy and increase of Ca(2+) influx by phosphodiesterase inhibition.
British journal of pharmacology 2000;129(5):901-8.
1999: Kazumasa Miyawaki; Yuichiro Yamada; H Yano; Hitoshi Niwa; Nobuhiro Ban; Yu Ihara; A Kubota; Shimpei Fujimoto; M Kajikawa; Akira Kuroe; Kinsuke Tsuda; Hisashi Hashimoto; Takahiro Yamashita; Takahito Jomori; Fumi Tashiro; Jun-ichi Miyazaki; Yutaka Seino
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14843-7.
1999: Tomokatsu Ikawa; Hiroshi Kawamoto; Shimpei Fujimoto; Yoshimoto Katsura
Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay.
The Journal of experimental medicine 1999;190(11):1617-26.
1999: Koichiro Ohmura; Hiroshi Kawamoto; Shimpei Fujimoto; S Ozaki; K Nakao; Yoshimoto Katsura
Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4788-95.
1999: N Kawakami; T Hayakawa; Shun Shimohama; Shimpei Fujimoto
The hydroxyl radical formation system in polymorphonuclear leukocytes.
Biological & pharmaceutical bulletin 1999;22(10):1034-7.
1999: Mariko Kajikawa; H Ishida; Shimpei Fujimoto; Eri Mukai; M Nishimura; Jun Fujita; Yoshiyuki Tsuura; Yasuo Okamoto; A W Norman; Yutaka Seino
An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic beta-cells through nongenomic signal transduction.
Endocrinology 1999;140(10):4706-12.
1999: Yoshiyuki Tsuura; Shimpei Fujimoto; Mariko Kajikawa; H Ishida; Yutaka Seino
Regulation of intracellular ATP concentration under conditions of reduced ATP consumption in pancreatic islets.
Biochemical and biophysical research communications 1999;261(2):439-44.
1999: Hiroko Tanino; J Yoshida; R Yamamoto; Y Kobayashi; Shun Shimohama; Shimpei Fujimoto
Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending fraction in the brain.
Biological & pharmaceutical bulletin 1999;22(8):794-8.
1999: N Kawakami; Hiroaki Takemasa; N Okamura; T Hayakawa; Shun Shimohama; Shimpei Fujimoto
Participation of cytosolic protein phosphatase in regulation of NADPH oxidase in polymorphonuclear leukocytes.
Biological & pharmaceutical bulletin 1999;22(6):556-60.
1999: Jun Fujita; Kinsuke Tsuda; Tomomi Takeda; L Yu; Shimpei Fujimoto; Mariko Kajikawa; M Nishimura; N Mizuno; Yoshiyuki Hamamoto; Eri Mukai; T Adachi; Yutaka Seino
Nisoldipine improves the impaired erythrocyte deformability correlating with elevated intracellular free calcium-ion concentration and poor glycaemic control in NIDDM.
British journal of clinical pharmacology 1999;47(5):499-506.
1999: Shun Shimohama; Hiroko Tanino; Shimpei Fujimoto
Changes in caspase expression in Alzheimer's disease: comparison with development and aging.
Biochemical and biophysical research communications 1999;256(2):381-4.
1999: Shimpei Fujimoto
[Therapeutic utility of biguanides in the treatment of NIDDM].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(3):657-62.
1999: Hiroshi Kawamoto; Koichiro Ohmura; Shimpei Fujimoto; Yoshimoto Katsura
Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2725-31.
1998: Shun Shimohama; Shimpei Fujimoto; Yoshio Sumida; Hiroko Tanino
Differential expression of rat brain bcl-2 family proteins in development and aging.
Biochemical and biophysical research communications 1998;252(1):92-6.
1998: H Ishida; Shigeaki Kato; M Nishimura; N Mizuno; Shimpei Fujimoto; Eri Mukai; Mariko Kajikawa; Yuichiro Yamada; H Odaka; Hiroki Ikeda; Yutaka Seino
Beneficial effect of long-term combined treatment with voglibose and pioglitazone on pancreatic islet function of genetically diabetic GK rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1998;30(11):673-8.
1998: J Tsuda; T Kimura; Hiroko Tanino; Shun Shimohama; Shimpei Fujimoto
Characterization of high- and low-molecular weight zinc-dependent acid phosphatases in bovine liver.
Biological & pharmaceutical bulletin 1998;21(11):1218-21.
1998: Shun Shimohama; Shimpei Fujimoto; Yoshio Sumida; K Akagawa; T Shirao; Yasuji Matsuoka; Tadatsugu Taniguchi
Differential expression of rat brain synaptic proteins in development and aging.
Biochemical and biophysical research communications 1998;251(1):394-8.
1998: Shimpei Fujimoto; J Tsuda; N Kawakami; Hiroko Tanino; Shun Shimohama
myo-Inositol monophosphatase in the brain has zinc ion-dependent tyrosine phosphatase activity.
General pharmacology 1998;31(3):469-75.
1998: Yoshiyuki Tsuura; H Ishida; M Nishimura; Shimpei Fujimoto; Mariko Kajikawa; Yutaka Seino
Ouabain suppresses ATP elevation in response to fuel secretagogues in pancreatic islets.
Biochemical and biophysical research communications 1998;249(3):853-7.
1998: Shun Shimohama; Hiroko Tanino; Yoshio Sumida; J Tsuda; Shimpei Fujimoto
Alteration of myo-inositol monophosphatase in Alzheimer's disease brains.
Neuroscience letters 1998;245(3):159-62.
1998: Shimpei Fujimoto; H Ishida; Shigeaki Kato; Yasuo Okamoto; K Tsuji; N Mizuno; S Ueda; Eri Mukai; Yutaka Seino
The novel insulinotropic mechanism of pimobendan: direct enhancement of the exocytotic process of insulin secretory granules by increased Ca2+ sensitivity in beta-cells.
Endocrinology 1998;139(3):1133-40.
1998: M Nishimura; H Ishida; Yoshiyuki Tsuura; Shigeaki Kato; N Mizuno; Shimpei Fujimoto; Eri Mukai; Mariko Kajikawa; M Usami; Yutaka Seino
Necessity of endogenous GTP derived from glucose-6-phosphate for insulin secretion augmented by glucose under protein kinase A activation.
Biochemical and biophysical research communications 1998;243(1):253-7.
1998: Shun Shimohama; Yoshio Sumida; Shimpei Fujimoto; Yasuji Matsuoka; Tadatsugu Taniguchi; Tadaomi Takenawa; J Kimura
Differential expression of rat brain phospholipase C isozymes in development and aging.
Biochemical and biophysical research communications 1998;243(1):210-6.
1998: Shun Shimohama; Y Sasaki; Shimpei Fujimoto; S Kamiya; Tadatsugu Taniguchi; T Takenawa; J Kimura
Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease.
Neuroscience 1998;82(4):999-1007.
1998: Eri Mukai; H Ishida; Shinichi Kato; Yoshiyuki Tsuura; Shimpei Fujimoto; A Ishida-Takahashi; Minoru Horie; K Tsuda; Yutaka Seino
Metabolic inhibition impairs ATP-sensitive K+ channel block by sulfonylurea in pancreatic beta-cells.
The American journal of physiology 1998;274(1 Pt 1):E38-44.
1998: N Kawakami; Hiroaki Takemasa; T Yamaguchi; T Hayakawa; Shun Shimohama; Shimpei Fujimoto
Indication of a protein kinase C-independent pathway for NADPH oxidase activation in human neutrophils.
Archives of biochemistry and biophysics 1998;349(1):89-94.
1996: N Kawakami; Shun Shimohama; T Hayakawa; Y Sumida; Shimpei Fujimoto
Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear leukocytes treated with pervanadate.
Biochimica et biophysica acta 1996;1314(1-2):167-74.
1996: N Kawakami; Y Koyama; J Tanaka; A Ohara; T Hayakawa; Shimpei Fujimoto
Inhibitory effect of acetylshikonin on the activation of NADPH oxidase in polymorphonuclear leukocytes in both whole cell and cell-free systems.
Biological & pharmaceutical bulletin 1996;19(10):1266-70.
1996: Shimpei Fujimoto; I Okano; Y Tanaka; Y Sumida; J Tsuda; N Kawakami; Shun Shimohama
Zinc-ion-dependent acid phosphatase exhibits magnesium-ion-dependent myo-inositol-1-phosphatase activity.
Biological & pharmaceutical bulletin 1996;19(6):882-5.
1995: Shun Shimohama; Shimpei Fujimoto; M Chachin; Tadatsugu Taniguchi; George Perry; Peter J Whitehouse; J Kimura
Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease.
Brain research 1995;699(1):125-9.
1995: Shun Shimohama; Shimpei Fujimoto; H Matsushima; T Takenawa; Tadatsugu Taniguchi; George Perry; Peter J Whitehouse; J Kimura
Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
Journal of neurochemistry 1995;64(6):2629-34.
1995: Shun Shimohama; H Matsushima; Shimpei Fujimoto; T Takenawa; Tadatsugu Taniguchi; M Kameyama; J Kimura
Differential involvement of phospholipase C isozymes in Alzheimer's disease.
Gerontology 1995;41 Suppl 1():13-9.
1994: Shun Shimohama; Shimpei Fujimoto; Tadatsugu Taniguchi; J Kimura
The endogenous substrate of low molecular weight acid phosphatase in the brain is an epidermal growth factor receptor.
Brain research 1994;662(1-2):185-8.
1993: Shun Shimohama; Shimpei Fujimoto; N Tresser; P Richey; George Perry; Peter J Whitehouse; Y Homma; T Takenawa; Tadatsugu Taniguchi; Toshihiko Suenaga
Aberrant phosphoinositide metabolism in Alzheimer's disease.
Annals of the New York Academy of Sciences 1993;695():46-9.
1993: Shun Shimohama; Shimpei Fujimoto; Tadatsugu Taniguchi; M Kameyama; J Kimura
Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brains.
Annals of neurology 1993;33(6):616-21.
1992: Shun Shimohama; Shimpei Fujimoto; Tadatsugu Taniguchi; J Kimura
Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease.
Brain research 1992;579(2):347-9.