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Masahiro Fujimuro

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Rumi Yamanokuchi; Hideyoshi Yokosawa; Sosuke Yoshinaga; Tadashi Watanabe; Nicole J de Voogd; Masahiro Fujimuro; Kumiko Imada; Noriyuki Iwasaki; Hikaru Kato; Fitje Losung; Remy E P Mangindaan; Mitsue Miyazaki; Michio Namikoshi; Henki Rotinsulu; Yasushi Saeki; Hiroaki Terasawa; Sachiko Tsukamoto
Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus.
Chizuka Higashi; Hiroki Kagawa; Rie Ohga; Chiaki Saji; Takahiro Taira; Koji Yamada; Masahiro Fujimuro
The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells.
Akira Ashizawa; Chizuka Higashi; Kazuki Masuda; Rie Ohga; Takahiro Taira; Masahiro Fujimuro
The Ubiquitin System and Kaposi's Sarcoma-Associated Herpesvirus.

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All Publications

2012: Rumi Yamanokuchi; Hideyoshi Yokosawa; Sosuke Yoshinaga; Tadashi Watanabe; Nicole J de Voogd; Masahiro Fujimuro; Kumiko Imada; Noriyuki Iwasaki; Hikaru Kato; Fitje Losung; Remy E P Mangindaan; Mitsue Miyazaki; Michio Namikoshi; Henki Rotinsulu; Yasushi Saeki; Hiroaki Terasawa; Sachiko Tsukamoto
Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus.
Bioorganic & medicinal chemistry 2012;20(14):4437-42.
2012: Chizuka Higashi; Hiroki Kagawa; Rie Ohga; Chiaki Saji; Takahiro Taira; Koji Yamada; Masahiro Fujimuro
The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells.
Biological & pharmaceutical bulletin 2012;35(5):725-30.
2012: Akira Ashizawa; Chizuka Higashi; Kazuki Masuda; Rie Ohga; Takahiro Taira; Masahiro Fujimuro
The Ubiquitin System and Kaposi's Sarcoma-Associated Herpesvirus.
Frontiers in microbiology 2012;3():66.
2011: Chiaki Saji; Koji Yamada; Chizuka Higashi; Yasufumi Niinaka; Kohji Noguchi; Masahiro Fujimuro
Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.
Biochemical and biophysical research communications 2011;415(4):573-8.
2011: Tadashi Nishiya; Kazuma Matsumoto; Satoshi Maekawa; Emi Kajita; Takahiro Horinouchi; Masahiro Fujimuro; Kouetsu Ogasawara; Takashi Uehara; Soichi Miwa
Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.
The Journal of biological chemistry 2011;286(11):9009-19.
2010: Yasufumi Niinaka; Kiyoshi Harada; Masahiro Fujimuro; Masamitsu Oda; Arayo Haga; Misa Hosoki; Narikazu Uzawa; Naoya Arai; Satoshi Yamaguchi; Masashi Yamashiro; Avraham Raz
Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis.
Cancer research 2010;70(22):9483-93.
2010: Hidenori Yoshioka; Kohji Noguchi; Kazuhiro Katayama; Junko Mitsuhashi; Satoshi Yamagoe; Masahiro Fujimuro; Yoshikazu Sugimoto
Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.
Biochemical and biophysical research communications 2010;394(4):1000-5.
2010: Osamu Ikeda; Yuto Miyasaka; Ryuji Yoshida; Akihiro Mizushima; Kenji Oritani; Yuichi Sekine; Makoto Kuroda; Teruhito Yasui; Masahiro Fujimuro; Ryuta Muromoto; Asuka Nanbo; Tadashi Matsuda
BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.
FEBS letters 2010;584(5):865-72.
2009: Osamu Ikeda; Sumihito Togi; Shinya Kamitani; Ryuta Muromoto; Yuichi Sekine; Asuka Nanbo; Masahiro Fujimuro; Tadashi Matsuda
Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2.
Biological & pharmaceutical bulletin 2009;32(7):1283-5.
2009: Osamu Ikeda; Yuichi Sekine; Akihiro Mizushima; Kenji Oritani; Teruhito Yasui; Masahiro Fujimuro; Ryuta Muromoto; Asuka Nanbo; Tadashi Matsuda
BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1.
FEBS letters 2009;583(10):1567-74.
2009: Ryuta Muromoto; Osamu Ikeda; Kanako Okabe; Sumihito Togi; Shinya Kamitani; Masahiro Fujimuro; Shizuko Harada; Kenji Oritani; Tadashi Matsuda
Epstein-Barr virus-derived EBNA2 regulates STAT3 activation.
Biochemical and biophysical research communications 2009;378(3):439-43.
2009: Satoshi Ichikawa; Masaki Otawa; Yasuhiro Teishikata; Koji Yamada; Masahiro Fujimuro; Hideyoshi Yokosawa; Akira Matsuda
9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
Nucleic acids symposium series (2004) 2009;(53):95-6.
2009: Yasuhito Wakasaya; Mitsunori Watanabe; Masahiko Tomiyama; Chieko Suzuki; Mandy Jackson; Masahiro Fujimuro; Tamaki Kimura; Yusuke Seino; Takeshi Kawarabayashi; Yukiko Yamamoto-Watanabe; Etsuro Matsubara; Ikumi Shirahama; Ayumi Takamura; Naoko Nakahata; Mikio Shoji
An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis.
Internal medicine (Tokyo, Japan) 2009;48(15):1311-3.
2007: Masahiro Fujimuro; S Diane Hayward; Hideyoshi Yokosawa
Molecular piracy: manipulation of the ubiquitin system by Kaposi's sarcoma-associated herpesvirus.
Reviews in medical virology 2007;17(6):405-22.
2007: Masahiro Fujimuro; Hideyoshi Yokosawa
[Regulations of gene expression and the ubiquitin-dependent pathway by human herpesvirus 8].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2007;52(10 Suppl):1113-20.
2007: Masaki Ohtawa; Satoshi Ichikawa; Yasuhiro Teishikata; Masahiro Fujimuro; Hideyoshi Yokosawa; Akira Matsuda
9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus.
Journal of medicinal chemistry 2007;50(9):2007-10.
2006: Masahiro Fujimuro
[Kaposi's sarcoma-associated herpesvirus and mechanisms of oncogenesis].
Uirusu 2006;56(2):209-18.
2006: Morie Nishiwaki; Masahiro Fujimuro; Yasuhiro Teishikata; Hisanori Inoue; Hitoshi Sasajima; Kazuhiro Nakaso; Kenji Nakashima; Hidetaka Sadanari; Tomohiro Yamamoto; Yoshie Fujiwara; Naoki Ogawa; Hideyoshi Yokosawa
Epidemiology of Epstein-Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus infections in peripheral blood leukocytes revealed by a multiplex PCR assay.
Journal of medical virology 2006;78(12):1635-42.
2006: S Diane Hayward; Jianyong Liu; Masahiro Fujimuro
Notch and Wnt signaling: mimicry and manipulation by gamma herpesviruses.
Science's STKE : signal transduction knowledge environment 2006;2006(335):re4.
2006: Masahiro Fujimuro; Kazuhiro Nakaso; Kenji Nakashima; Hidetaka Sadanari; Inoue Hisanori; Yasuhiro Teishikata; S Diane Hayward; Hideyoshi Yokosawa
Multiplex PCR-based DNA array for simultaneous detection of three human herpesviruses, EVB, CMV and KSHV.
Experimental and molecular pathology 2006;80(2):124-31.
2006: Masahiro Fujimuro
[Kaposi's sarcoma-associated herpesvirus and cell signaling].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 3():558-63.
2006: Ryuta Muromoto; Kanako Okabe; Masahiro Fujimuro; Kenji Sugiyama; Hideyoshi Yokosawa; Tsukasa Seya; Tadashi Matsuda
Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.
FEBS letters 2006;580(1):93-8.
2006: Masahiro Fujimuro; Hisanori Inoue; Yasuhiro Teishikata; Yuriko Ishida; Hideyoshi Yokosawa
Apoptotic effect of ganciclovir on primary effusion lymphoma cells infected with Kaposi's sarcoma-associated herpesvirus.
Nucleosides, nucleotides & nucleic acids 2006;25(4-6):635-45.
2005: Masahiro Fujimuro; Tadashi Nishiya; Yasuyuki Nomura; Hideyoshi Yokosawa
Involvement of polyubiquitin chains via specific chain linkages in stress response in mammalian cells.
Biological & pharmaceutical bulletin 2005;28(12):2315-8.
2005: Masahiro Fujimuro; Jianyong Liu; Jian Zhu; Hideyoshi Yokosawa; S Diane Hayward
Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen.
Journal of virology 2005;79(16):10429-41.
2005: Byoung-Il Bae; Hong Xu; Shuichi Igarashi; Masahiro Fujimuro; Nishant Agrawal; Yoichi Taya; S Diane Hayward; Timothy H Moran; Craig Montell; Christopher A Ross; Solomon H Snyder; Akira Sawa
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.
Neuron 2005;47(1):29-41.
2005: Makoto R Hara; Nishant Agrawal; Sangwon Kim; Matthew Cascio; Masahiro Fujimuro; Yuji Ozeki; Masaaki Takahashi; Jaime H Cheah; Stephanie Tankou; Lynda D Hester; Christopher D Ferris; S Diane Hayward; Solomon H Snyder; Akira Sawa
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.
Nature cell biology 2005;7(7):665-74.
2005: Sachiko Tsukamoto; Hiroshi Hirota; Misako Imachi; Masahiro Fujimuro; Hiroyuki Onuki; Tomihisa Ohta; Hideyoshi Yokosawa
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
Bioorganic & medicinal chemistry letters 2005;15(1):191-4.
2005: Masahiro Fujimuro; Hideyoshi Yokosawa
Production of antipolyubiquitin monoclonal antibodies and their use for characterization and isolation of polyubiquitinated proteins.
Methods in enzymology 2005;399():75-86.
2004: Masahiro Fujimuro; S Diane Hayward
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
Journal of molecular medicine (Berlin, Germany) 2004;82(4):223-31.
2004: Masahiro Fujimuro
[The role of Kaposi's sarcoma-associated herpesvirus in oncogenesis].
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(2):140-3.
2003: Frederick Y Wu; Shizhen Emily Wang; Qi-Qun Tang; Masahiro Fujimuro; Chuang-Jiun Chiou; Qizhi Zheng; Honglin Chen; S Diane Hayward; M Daniel Lane; Gary S Hayward
Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1).
Journal of virology 2003;77(16):8893-914.
2003: Masahiro Fujimuro; S Diane Hayward
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus manipulates the activity of glycogen synthase kinase-3beta.
Journal of virology 2003;77(14):8019-30.
2003: Masahiro Fujimuro; Frederick Y Wu; Colette ApRhys; Henry Kajumbula; David B Young; Gary S Hayward; S Diane Hayward
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.
Nature medicine 2003;9(3):300-6.
2003: Frederick Y Wu; Honglin Chen; Shizhen Emily Wang; Colette ApRhys; Gangling Liao; Masahiro Fujimuro; Christopher J Farrell; Jian Huang; S Diane Hayward; Gary S Hayward
CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle.
Journal of virology 2003;77(2):1481-500.
2003: Shizhen Emily Wang; Frederick Y Wu; Masahiro Fujimuro; jianchao zong; S Diane Hayward; Gary S Hayward
Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP.
Journal of virology 2003;77(1):600-23.
2002: Anita Krithivas; Masahiro Fujimuro; Magdalena Weidner; David B Young; S Diane Hayward
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes.
Journal of virology 2002;76(22):11596-604.
2002: Frederick Y Wu; Qi-Qun Tang; Honglin Chen; Colette ApRhys; Christopher Farrell; Jianmeng Chen; Masahiro Fujimuro; M Daniel Lane; Gary S Hayward
Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10683-8.
2002: Yuki Yanagawa; Seiichiro Hasezawa; Fumi Kumagai; Masayoshi Oka; Masahiro Fujimuro; Tae Naito; Taro Makino; Hideyoshi Yokosawa; Keiji Tanaka; Atsushi Komamine; Junji Hashimoto; Takahide Sato; Hiroki Nakagawa
Cell-cycle dependent dynamic change of 26S proteasome distribution in tobacco BY-2 cells.
Plant & cell physiology 2002;43(6):604-13.
2001: L Chen; Gangling Liao; Masahiro Fujimuro; O John Semmes; S Diane Hayward
Properties of two EBV Mta nuclear export signal sequences.
Virology 2001;288(1):119-28.
2000: Shaoyu Zhou; Masahiro Fujimuro; James Hsieh; Lieping Chen; A Miyamoto; Gerry Weinmaster; S Diane Hayward
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
Molecular and cellular biology 2000;20(7):2400-10.
2000: Y Tone; N Tanahashi; Keiichi Tanaka; Masahiro Fujimuro; Hideyoshi Yokosawa; Akio Toh-E
Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells.
Gene 2000;243(1-2):37-45.
2000: Shaoyu Zhou; Masahiro Fujimuro; James Hsieh; Lieping Chen; S Diane Hayward
A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
Journal of virology 2000;74(4):1939-47.
1999: J Takeuchi; Masahiro Fujimuro; H Yokosawa; Keiichi Tanaka; Akio Toh-E
Rpn9 is required for efficient assembly of the yeast 26S proteasome.
Molecular and cellular biology 1999;19(10):6575-84.
1999: Takashi Uehara; J Matsuno; M Kaneko; Tadashi Nishiya; Masahiro Fujimuro; Hideyoshi Yokosawa; Yasuyuki Nomura
Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB linked to chemokine production.
The Journal of biological chemistry 1999;274(22):15875-82.
1998: Masahiro Fujimuro; H Takada; Y Saeki; Akio Toh-E; K Tanaka; H Yokosawa
Growth-dependent change of the 26S proteasome in budding yeast.
Biochemical and biophysical research communications 1998;251(3):818-23.
1998: Masahiro Fujimuro; K Tanaka; Hideyoshi Yokosawa; A Toh-e
Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae.
FEBS letters 1998;423(2):149-54.
1997: Masahiro Fujimuro; H Sawada; Hideyoshi Yokosawa
Dynamics of ubiquitin conjugation during heat-shock response revealed by using a monoclonal antibody specific to multi-ubiquitin chains.
European journal of biochemistry / FEBS 1997;249(2):427-33.
1997: K Kominami; N Okura; M Kawamura; George N DeMartino; CA Slaughter; N Shimbara; CH Chung; Masahiro Fujimuro; Hideyoshi Yokosawa; Y Shimizu; N Tanahashi; Keiichi Tanaka; Akio Toh-E
Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.
Molecular biology of the cell 1997;8(1):171-87.
1996: C Tsurumi; Y Shimizu; M Saeki; S Kato; George N DeMartino; C A Slaughter; Masahiro Fujimuro; Hideyoshi Yokosawa; M Yamasaki; K B Hendil; Akio Toh-E; N Tanahashi; K Tanaka
cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
European journal of biochemistry / FEBS 1996;239(3):912-21.
1996: Takeshi Iwatsubo; H Yamaguchi; Masahiro Fujimuro; Hideyoshi Yokosawa; Yasuo Ihara; John Q Trojanowski; Virginia M-Y Lee
Lewy bodies: purification from diffuse Lewy body disease brains.
Annals of the New York Academy of Sciences 1996;786():195-205.
1996: K Yokota; Susumu Kagawa; Y Shimizu; H Akioka; C Tsurumi; C Noda; Masahiro Fujimuro; Hideyoshi Yokosawa; T Fujiwara; E Takahashi; M Ohba; M Yamasaki; George N DeMartino; C A Slaughter; Akio Toh-E; K Tanaka
CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.
Molecular biology of the cell 1996;7(6):853-70.
1996: Takeshi Iwatsubo; H Yamaguchi; Masahiro Fujimuro; Hideyoshi Yokosawa; Yasuo Ihara; John Q Trojanowski; Virginia M-Y Lee
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
The American journal of pathology 1996;148(5):1517-29.
1995: K Kominami; George N DeMartino; C R Moomaw; C A Slaughter; N Shimbara; Masahiro Fujimuro; Hideyoshi Yokosawa; H Hisamatsu; N Tanahashi; Y Shimizu
Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.
The EMBO journal 1995;14(13):3105-15.
1994: Masahiro Fujimuro; H Sawada; Hideyoshi Yokosawa
Production and characterization of monoclonal antibodies specific to multi-ubiquitin chains of polyubiquitinated proteins.
FEBS letters 1994;349(2):173-80.
1993: H Sawada; K Muto; Masahiro Fujimuro; T Akaishi; M T Sawada; Hideyoshi Yokosawa; A L Goldberg
Different ratios in 20 S proteasomes and regulatory subunit complexes in two isoforms of the 26 S proteasome purified from rabbit skeletal muscle.
FEBS letters 1993;335(2):207-12.