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Yasushi Fujio

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Hiroshi Okamoto; Hiroyuki Tsutsui; Tsutomu Yamazaki; Tsutomu Yoshikawa; Junichi Azuma; Yasushi Fujio; Masatsugu Hori; Tohru Izumi; Akira Kitabatake; Masunori Matsuzaki; Ryozo Nagai; Shinpei Nonen; Yasuo Ohashi
Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study.
Hiroyuki Nakayama; Yasushi Fujio; Osamu Yamaguchi
[The Roles of Calcium and Phosphorus in Cardiovascular Diseases. Calcium dependent signaling in cardiac hypertrophy and cell death].
Masanori Obana; Momoko Shiragaki; Kana Takewaki; Tomomi Yamashita; Minoru Yoshiyama; Akiko Hayama; Tomohiko Iwakura; Shohei Kumagai; Makiko Maeda; Goro Matsumiya; Kaori Miyamoto; Akimitsu Miyawaki; Shiho Murasawa; Hiroyuki Nakayama; Yasushi Fujio
Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart.

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2013: Hiroshi Okamoto; Hiroyuki Tsutsui; Tsutomu Yamazaki; Tsutomu Yoshikawa; Junichi Azuma; Yasushi Fujio; Masatsugu Hori; Tohru Izumi; Akira Kitabatake; Masunori Matsuzaki; Ryozo Nagai; Shinpei Nonen; Yasuo Ohashi
Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study.
International journal of cardiology 2013;164(2):238-44.
2013: Hiroyuki Nakayama; Yasushi Fujio; Osamu Yamaguchi
[The Roles of Calcium and Phosphorus in Cardiovascular Diseases. Calcium dependent signaling in cardiac hypertrophy and cell death].
Clinical calcium 2013;23(4):505-15.
2012: Masanori Obana; Momoko Shiragaki; Kana Takewaki; Tomomi Yamashita; Minoru Yoshiyama; Akiko Hayama; Tomohiko Iwakura; Shohei Kumagai; Makiko Maeda; Goro Matsumiya; Kaori Miyamoto; Akimitsu Miyawaki; Shiho Murasawa; Hiroyuki Nakayama; Yasushi Fujio
Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart.
American journal of physiology. Heart and circulatory physiology 2012;303(5):H569-77.
2012: Kaori Higuchi; Kuniyasu Ikeoka; Yoh Arita; Yasushi Fujio; Takahiro Hashimoto; Tadashi Kuroda; Takashi Minami; Naoki Mochizuki; Yoshikazu Nakaoka; Keigo Nishida; Wataru Shioyama; Mikiyasu Shirai; Keiko Yamauchi-Takihara; Taku Yasui; Issei Komuro
Endothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation and atherosclerosis in apolipoprotein E knockout mice.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(8):2031-40.
2011: Hiroyuki Nakayama; Ryosuke Oguro; Mitsuru Ohishi; Hiroshi Okamoto; Hiromi Rakugi; Ken Sugimoto; Kei Kamide; Tomohiro Katsuya; Kazuo Komamura; Makiko Maeda; Kyotaka Matsumoto; Hiromi Nagai; Junichi Azuma; Yasushi Fujio
Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population.
Hypertension research : official journal of the Japanese Society of Hypertension 2011;34(10):1141-6.
2011: Tomomi Yamashita; Minoru Fujimoto; Akiko Hayama; Tomohiko Iwakura; Yasukatsu Izumi; Haruyo Kawaguchi; Tadamitsu Kishimoto; Issei Komuro; Makiko Maeda; Kazuki Matsui; Tetsuji Naka; Hiroyuki Nakayama; Masanori Obana; Yoshiyuki Ohsugi; Yasushi Fujio
IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis.
Cardiovascular research 2011;91(4):640-8.
2011: Tomohiko Iwakura; Hideaki Kaneto; Naoto Katakami; Issei Komuro; Makiko Maeda; Tomomi Mohri; Hiroyuki Nakayama; Masanori Obana; Toru Oka; Tomomi Yamashita; Junichi Azuma; Tatsuto Hamatani; Yasushi Fujio
STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo.
Journal of molecular and cellular cardiology 2011;51(2):207-14.
2011: Takashi Kijima; Toshiyuki Minami; Izumi Nagatomo; Shinpei Nonen; Yasushi Otani; Tomohito Shimizu; Isao Tachibana; Ryo Takahashi; Yoshito Takeda; Junichi Azuma; Yasushi Fujio; Mitsugi Furukawa; Sho Goya; Haruhiko Hirata; Hiroshi Kida; Ichiro Kawase
Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(19):e588-90.
2011: Wataru Shioyama; Yoshikazu Nakaoka; Kaori Higuchi; Takashi Minami; Yoshiaki Taniyama; Keigo Nishida; Hiroyasu Kidoya; Takashi Sonobe; Hisamichi Naito; Yoh Arita; Takahiro Hashimoto; Tadashi Kuroda; Yasushi Fujio; Mikiyasu Shirai; Nobuyuki Takakura; Ryuichi Morishita; Keiko Yamauchi-Takihara; Tatsuhiko Kodama; Toshio Hirano; Naoki Mochizuki; Issei Komuro
Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.
Circulation research 2011;108(6):664-75.
2011: Ikumi Washio; Makiko Maeda; Chika Sugiura; Ryota Shiga; Mitsuhiro Yoshida; Shinpei Nonen; Yasushi Fujio; Junichi Azuma
Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(1):1-3.
2010: Yasushi Fujio
RGS2 determines the preventive effects of ARBs against vascular remodeling: toward personalized medicine of anti-hypertensive therapy with ARBs.
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(12):1221-2.
2010: Yoshikazu Nakaoka; Wataru Shioyama; Satoshi Kunimoto; Yoh Arita; Kaori Higuchi; Kaori Yamamoto; Yasushi Fujio; Keigo Nishida; Tadashi Kuroda; Hisao Hirota; Keiko Yamauchi-Takihara; Toshio Hirano; Issei Komuro; Naoki Mochizuki
SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.
Journal of molecular and cellular cardiology 2010;49(2):157-64.
2010: Masanori Obana; Makiko Maeda; Kiyoshi Takeda; Akiko Hayama; Tomomi Mohri; Tomomi Yamashita; Yoshikazu Nakaoka; Issei Komuro; Koji Takeda; Goro Matsumiya; Junichi Azuma; Yasushi Fujio
Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.
Circulation 2010;121(5):684-91.
2009: Masako Ohno; Akiko Yamamoto; Ayumu Ono; Genta Miura; Masanobu Funamoto; Yasuhiko Takemoto; Kinya Otsu; Yasushi Kouno; Tomoko Tanabe; Yuiko Masunaga; Shinpei Nonen; Yasushi Fujio; Junichi Azuma
Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.
European journal of clinical pharmacology 2009;65(11):1097-103.
2009: Yoshimune Hiramoto; Wataru Shioyama; Kaori Higuchi; Yoh Arita; Tadashi Kuroda; Yasushi Sakata; Yoshikazu Nakaoka; Yasushi Fujio; Keiko Yamauchi-Takihara
Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension.
Journal of cardiology 2009;53(3):374-80.
2009: Tomomi Mohri; Yasushi Fujio; Masanori Obana; Tomohiko Iwakura; Koichi Matsuda; Makiko Maeda; Junichi Azuma
Signals through glycoprotein 130 regulate the endothelial differentiation of cardiac stem cells.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(5):754-60.
2009: Takashi Ito; Yasushi Fujio; Stephen W Schaffer; Junichi Azuma
Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte.
Advances in experimental medicine and biology 2009;643():523-32.
2009: Takashi Ito; Satoko Muraoka; Kyoko Takahashi; Yasushi Fujio; Stephen W Schaffer; Junichi Azuma
Beneficial effect of taurine treatment against doxorubicin-induced cardiotoxicity in mice.
Advances in experimental medicine and biology 2009;643():65-74.
2008: Yasuhiro Yamamoto; Yuki Hoshino; Takashi Ito; Tetsuro Nariai; Tomomi Mohri; Masanori Obana; Nozomi Hayata; Yoriko Uozumi; Makiko Maeda; Yasushi Fujio; Junichi Azuma
Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes.
Cardiovascular research 2008;79(1):89-96.
2008: Nozomi Hayata; Yasushi Fujio; Yasuhiro Yamamoto; Tomohiko Iwakura; Masanori Obana; Mika Takai; Tomomi Mohri; Shinpei Nonen; Makiko Maeda; Junichi Azuma
Connective tissue growth factor induces cardiac hypertrophy through Akt signaling.
Biochemical and biophysical research communications 2008;370(2):274-8.
2008: Takashi Ito; Yasushi Kimura; Yoriko Uozumi; Mika Takai; Satoko Muraoka; Takahisa Matsuda; Kei Ueki; Minoru Yoshiyama; Masahito Ikawa; Masaru Okabe; Stephen W Schaffer; Yasushi Fujio; Junichi Azuma
Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy.
Journal of molecular and cellular cardiology 2008;44(5):927-37.
2008: Makiko Maeda; Isamu Yamamoto; Masakatsu Fukuda; Takashi Motomura; Mari Nishida; Shinpei Nonen; Yasushi Fujio; Soji Kasayama; Junichi Azuma
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients.
Journal of diabetes and its complications 2008;22(2):119-25.
2008: Shinpei Nonen; Isamu Yamamoto; Jianmin Liu; Makiko Maeda; Takashi Motomura; Tsuyoshi Igarashi; Yasushi Fujio; Junichi Azuma
Adrenergic beta1 receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients.
Biological & pharmaceutical bulletin 2008;31(2):295-8.
2008: Shinpei Nonen; Hiroshi Okamoto; Yasushi Fujio; Y Takemoto; M Yoshiyama; T Hamaguchi; Y Matsui; J Yoshikawa; Akira Kitabatake; Junichi Azuma
Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy.
The pharmacogenomics journal 2008;8(1):78-84.
2007: Tadashi Kuroda; Hisao Hirota; Yasushi Fujio; Shoko Sugiyama; Mitsuru Masaki; Yoshimune Hiramoto; Wataru Shioyama; Kitaro Okamoto; Masatsugu Hori; Keiko Yamauchi-Takihara
Carbacyclin induces carnitine palmitoyltransferase-1 in cardiomyocytes via peroxisome proliferator-activated receptor (PPAR) delta independent of the IP receptor signaling pathway.
Journal of molecular and cellular cardiology 2007;43(1):54-62.
2007: Takashi Ito; Koko Asakura; Katsuhiko Tougou; Tsuyoshi Fukuda; Ryuji Kubota; Shinpei Nonen; Yasushi Fujio; Junichi Azuma
Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes.
Molecular pharmacology 2007;72(1):173-81.
2007: Ryusuke Kimura; Makiko Maeda; Atsushi Arita; Yuichi Oshima; Masanori Obana; Takashi Ito; Yasuhiro Yamamoto; Tomomi Mohri; Tadamitsu Kishimoto; Ichiro Kawase; Yasushi Fujio; Junichi Azuma
Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine.
Cytokine 2007;38(2):107-15.
2007: Katsuhiko Tougou; Tsuyoshi Fukuda; Takashi Ito; Hiroshi Yamazaki; Yasushi Fujio; Junichi Azuma
Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.
Drug metabolism and pharmacokinetics 2007;22(2):125-8.
2007: Yoshimune Hiramoto; Wataru Shioyama; Tadashi Kuroda; Mitsuru Masaki; Shoko Sugiyama; Kitaro Okamoto; Hisao Hirota; Yasushi Fujio; Masatsugu Hori; Keiko Yamauchi-Takihara
Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(3):367-9.
2007: Masako Yamane; Takahisa Matsuda; Takashi Ito; Yasushi Fujio; Kyoko Takahashi; Junichi Azuma
Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress.
Biochemical and biophysical research communications 2007;353(4):1023-7.
2007: Takashi Ito; Yasushi Fujio; Kyoko Takahashi; Junichi Azuma
Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes.
The Journal of biological chemistry 2007;282(2):1152-60.
2006: Makiko Maeda; Yasushi Fujio; Junichi Azuma
MTHFR gene polymorphism and diabetic retinopathy.
Current diabetes reviews 2006;2(4):467-76.
2006: Tsuyoshi Fukuda; Tomoko Tanabe; Masako Ohno; Katsuhiko Tougou; Yasushi Fujio; Junichi Azuma; Isamu Yamamoto; Akira Takeda
Warfarin dose requirement for patients with both VKORC1 3673A/A and CYP2C9*3/*3 genotypes.
Clinical pharmacology and therapeutics 2006;80(5):553-4.
2006: Masayoshi Yasui; Hirofumi Yamamoto; Chew Yee Ngan; Bazarragchaa Damdinsuren; Yurika Sugita; Hiroki Fukunaga; Jinyu Gu; Makiko Maeda; Ichiro Takemasa; Masataka Ikeda; Yasushi Fujio; Mitsugu Sekimoto; Nariaki Matsuura; I Bernard Weinstein; Morito Monden
Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: implication of tumor vascularization.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4720-9.
2006: Takahisa Matsuda; Yasushi Fujio; Tetsurou Nariai; Takashi Ito; Masako Yamane; Tomoka Takatani; Kyoko Takahashi; Junichi Azuma
N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes.
Journal of molecular and cellular cardiology 2006;40(4):495-502.
2006: Yoriko Uozumi; Takashi Ito; Yuki Hoshino; Tomomi Mohri; Makiko Maeda; Kyoko Takahashi; Yasushi Fujio; Junichi Azuma
Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles.
The Biochemical journal 2006;394(Pt 3):699-706.
2006: Tomomi Mohri; Yasushi Fujio; Makiko Maeda; Takashi Ito; Tomohiko Iwakura; Yuichi Oshima; Yoriko Uozumi; Masashi Segawa; Hiroshi Yamamoto; Tadamitsu Kishimoto; Junichi Azuma
Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells.
The Journal of biological chemistry 2006;281(10):6442-7.
2006: T Kubota; C Nakajima-Taniguchi; Tsuyoshi Fukuda; Masanobu Funamoto; M Maeda; E Tange; R Ueki; K Kawashima; H Hara; Yasushi Fujio; Junichi Azuma
CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation.
The pharmacogenomics journal 2006;6(2):115-9.
2006: Yoriko Uozumi; Takashi Ito; Kyoko Takahashi; Takahisa Matsuda; Tomomi Mohri; Yasushi Kimura; Yasushi Fujio; Junichi Azuma
Myogenic induction of taurine transporter prevents dexamethasone-induced muscle atrophy.
Advances in experimental medicine and biology 2006;583():265-70.
2006: Kyoko Takahashi; Tomoka Takatani; Yoriko Uozumi; Takashi Ito; Takahisa Matsuda; Yasushi Fujio; Stephen W Schaffer; Junichi Azuma
Molecular mechanisms of cardioprotection by taurine on ischemia-induced apoptosis in cultured cardiomyocytes.
Advances in experimental medicine and biology 2006;583():257-63.
2006: Takashi Ito; Yasushi Fujio; Yoriko Uozumi; Takahisa Matsuda; Makiko Maeda; Kyoko Takahashi; Junichi Azuma
TauT gene expression is regulated by TonEBP and plays a role in cell survival.
Advances in experimental medicine and biology 2006;583():91-8.
2005: Quan Lin; Raymond Lai; Lucian R Chirieac; Changping Li; Vilmos A Thomazy; Ioannis Grammatikakis; George Z Rassidakis; Wei Zhang; Yasushi Fujio; Keita Kunisada; Stanley R Hamilton; Hesham M Amin
Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.
The American journal of pathology 2005;167(4):969-80.
2005: Shinpei Nonen; Hiroshi Okamoto; Masatoshi Akino; Yutaka Matsui; Yasushi Fujio; Minoru Yoshiyama; Yasuhiko Takemoto; Junichi Yoshikawa; Junichi Azuma; Akira Kitabatake
No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population.
British journal of clinical pharmacology 2005;60(4):414-7.
2005: Chinuyo Sumita; Masako Yamane; Takahisa Matsuda; Makiko Maeda; Tetsurou Nariai; Yasushi Fujio; Junichi Azuma
Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages.
FEBS letters 2005;579(18):4038-42.
2005: Yuichi Oshima; Yasushi Fujio; Tsuyoshi Nakanishi; Norio Itoh; Yasuhiro Yamamoto; Shinji Negoro; Keiichi Tanaka; Tadamitsu Kishimoto; Ichiro Kawase; Junichi Azuma
STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart.
Cardiovascular research 2005;65(2):428-35.
2005: Takahisa Matsuda; Kyoko Takahashi; Tetsurou Nariai; Takashi Ito; Tomoka Takatani; Yasushi Fujio; Junichi Azuma
N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes.
Biochemical and biophysical research communications 2005;326(1):228-32.
2004: Tomoka Takatani; Kyoko Takahashi; Yoriko Uozumi; Eriko Shikata; Yasuhiro Yamamoto; Takashi Ito; Takahisa Matsuda; Stephen W Schaffer; Yasushi Fujio; Junichi Azuma
Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome.
American journal of physiology. Cell physiology 2004;287(4):C949-53.
2004: Hisao Hirota; Masahiro Izumi; Tomoyuki Hamaguchi; Shoko Sugiyama; Eiki Murakami; Keita Kunisada; Yasushi Fujio; Yuichi Oshima; Yoshikazu Nakaoka; Keiko Yamauchi-Takihara
Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure.
Heart and vessels 2004;19(5):237-41.
2004: Yasushi Fujio; Takahisa Matsuda; Yuichi Oshima; Makiko Maeda; Tomomi Mohri; Takashi Ito; Tomoka Takatani; Mayo Hirata; Yoshikazu Nakaoka; Ryusuke Kimura; Tadamitsu Kishimoto; Junichi Azuma
Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes.
FEBS letters 2004;573(1-3):202-6.
2004: Takashi Ito; Yasushi Fujio; Mayo Hirata; Tomoka Takatani; Takahisa Matsuda; Satoko Muraoka; Kyoko Takahashi; Junichi Azuma
Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells.
The Biochemical journal 2004;382(Pt 1):177-82.
2004: Chinuyo Sumita; Makiko Maeda; Yasushi Fujio; Jooyeon Kim; Junko Fujitsu; Soji Kasayama; Isamu Yamamoto; Junichi Azuma
Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage.
Biochimica et biophysica acta 2004;1673(3):115-21.
2004: Hesham M Amin; Timothy J McDonnell; Yupo Ma; Quan Lin; Yasushi Fujio; Keita Kunisada; Vasiliki Leventaki; Pamela Das; George Z Rassidakis; Cathy Cutler; L Jeffrey Medeiros; Raymond Lai
Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma.
Oncogene 2004;23(32):5426-34.
2004: Shoko Sugiyama; Hisao Hirota; Maki Yoshida; Yukiko Takemura; Yoshikazu Nakaoka; Yuichi Oshima; Kazuo Terai; Masahiro Izumi; Yasushi Fujio; Shinji Hasegawa; Toshiaki Mano; Yoshiaki Nakatsuchi; Masatsugu Hori; Keiko Yamauchi-Takihara; Ichiro Kawase
Novel insertional mutation in the bone morphogenetic protein receptor type II associated with sporadic primary pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2004;68(6):592-4.
2004: Raymond Lai; George Z Rassidakis; L Jeffrey Medeiros; Latha Ramdas; Andre Goy; Cathy Cutler; Yasushi Fujio; Keita Kunisada; Hesham M Amin; Frederic Gilles
Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.
The American journal of pathology 2004;164(6):2251-8.
2004: Tomoka Takatani; Kyoko Takahashi; Yoriko Uozumi; Takahisa Matsuda; Takashi Ito; Stephen W Schaffer; Yasushi Fujio; Junichi Azuma
Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway.
Biochemical and biophysical research communications 2004;316(2):484-9.
2004: Tsuyoshi Fukuda; S Onishi; Shuichi Fukuen; Yuka Ikenaga; M Ohno; K Hoshino; K Matsumoto; A Maihara; K Momiyama; T Ito; Yasushi Fujio; Junichi Azuma
CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers.
The pharmacogenomics journal 2004;4(1):34-9.
2003: Makiko Maeda; Isamu Yamamoto; Yasushi Fujio; Junichi Azuma
Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages.
Biochimica et biophysica acta 2003;1623(1):41-6.
2003: Yoshikazu Nakaoka; Keigo Nishida; Yasushi Fujio; Masahiro Izumi; Kazuo Terai; Yuichi Oshima; Shoko Sugiyama; Satoshi Matsuda; Shigeo Koyasu; Keiko Yamauchi-Takihara; Toshio Hirano; Ichiro Kawase; Hisao Hirota
Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes.
Circulation research 2003;93(3):221-9.
2003: Makiko Maeda; Isamu Yamamoto; Masakatsu Fukuda; Mari Nishida; Junko Fujitsu; Shinpei Nonen; Tsuyoshi Igarashi; Takashi Motomura; Makiko Inaba; Yasushi Fujio; Junichi Azuma
MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation.
Diabetes care 2003;26(2):547-8.
2002: Yuichi Oshima; Yasushi Fujio; Masanobu Funamoto; Shinji Negoro; Masahiro Izumi; Yoshikazu Nakaoka; Hisao Hirota; Keiko Yamauchi-Takihara; Ichiro Kawase
Aldosterone augments endothelin-1-induced cardiac myocyte hypertrophy with the reinforcement of the JNK pathway.
FEBS letters 2002;524(1-3):123-6.
2002: Yuichi Oshima; Hisao Hirota; Hiroyuki Nagai; Masahiro Izumi; Yoshikazu Nakaoka; Tomoaki Osugi; Yasushi Fujio; Hitone Tateyama; Masanori Kikui; Keiko Yamauchi-Takihara; Ichiro Kawase
Images in cardiovascular medicine. Specific cardiomyopathy caused by multisystemic lipid storage in Jordan's anomaly.
Circulation 2002;106(2):280-1.
2002: Yoshikazu Nakaoka; Kota Iwahori; Keita Kunisada; Yasushi Fujio; Masahiro Izumi; Tomoaki Osugi; Yuichi Oshima; Hisao Hirota; Keiko Yamauchi-Takihara
A case of hypereosinophilic syndrome presenting mid-ventricular obstruction.
Heart and vessels 2002;16(3):121-4.
2002: Keita Kunisada; Eiroh Tone; Shinji Negoro; Yoshikazu Nakaoka; Yuichi Oshima; Tomoaki Osugi; Masanobu Funamoto; Masahiro Izumi; Yasushi Fujio; Hisao Hirota; Keiko Yamauchi-Takihara
Bcl-xl reduces doxorubicin-induced myocardial damage but fails to control cardiac gene downregulation.
Cardiovascular research 2002;53(4):936-43.
2002: Tomoaki Osugi; Yuichi Oshima; Yasushi Fujio; Masanobu Funamoto; Atsuko Yamashita; Shinji Negoro; Keita Kunisada; Masahiro Izumi; Yoshikazu Nakaoka; Hisao Hirota; Masaru Okabe; Keiko Yamauchi-Takihara; Ichiro Kawase; Tadamitsu Kishimoto
Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart.
The Journal of biological chemistry 2002;277(8):6676-81.
2001: Shinji Negoro; Keita Kunisada; Yasushi Fujio; Masanobu Funamoto; Martine I Darville; D L Eizirik; Tomoaki Osugi; Masahiro Izumi; Yuichi Oshima; Yoshikazu Nakaoka; Hisao Hirota; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase.
Circulation 2001;104(9):979-81.
2001: Masahiro Izumi; Yasushi Fujio; Keita Kunisada; Shinji Negoro; Eiroh Tone; Masanobu Funamoto; Tomoaki Osugi; Yuichi Oshima; Yoshikazu Nakaoka; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara; Hisao Hirota
Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway.
The Journal of biological chemistry 2001;276(33):31133-41.
2001: Shinji Negoro; H Oh; Eiroh Tone; Keita Kunisada; Yasushi Fujio; K Walsh; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction.
Circulation 2001;103(4):555-61.
2000: Masanobu Funamoto; S Hishinuma; Yasushi Fujio; Y Matsuda; Keita Kunisada; H Oh; Shinji Negoro; Eiroh Tone; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation.
Journal of molecular and cellular cardiology 2000;32(7):1275-84.
2000: Masanobu Funamoto; Yasushi Fujio; Keita Kunisada; Shinji Negoro; Eiroh Tone; Tomoaki Osugi; Hisao Hirota; Masahiro Izumi; Kazuyuki Yoshizaki; K Walsh; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes.
The Journal of biological chemistry 2000;275(14):10561-6.
1999: S Hishinuma; Masanobu Funamoto; Yasushi Fujio; Keita Kunisada; Keiko Yamauchi-Takihara
Hypoxic stress induces cardiotrophin-1 expression in cardiac myocytes.
Biochemical and biophysical research communications 1999;264(2):436-40.
1999: H Matsui; Y Ihara; Yasushi Fujio; Keita Kunisada; Shizuo Akira; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes.
Cardiovascular research 1999;42(1):104-12.
1998: Eiroh Tone; Keita Kunisada; Yasushi Fujio; H Matsui; Shinji Negoro; H Oh; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Angiotensin II interferes with leukemia inhibitory factor-induced STAT3 activation in cardiac myocytes.
Biochemical and biophysical research communications 1998;253(1):147-50.
1998: Keita Kunisada; Eiroh Tone; Yasushi Fujio; H Matsui; Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.
Circulation 1998;98(4):346-52.
1998: H Oh; Yasushi Fujio; Keita Kunisada; Hisao Hirota; H Matsui; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes.
The Journal of biological chemistry 1998;273(16):9703-10.
1997: Yasushi Fujio; Keita Kunisada; Hisao Hirota; Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.
The Journal of clinical investigation 1997;99(12):2898-905.
1997: C Nakajima-Taniguchi; H Matsui; Yasushi Fujio; Seiki Nagata; Tadamitsu Kishimoto; Keiko Yamauchi-Takihara
Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy.
Journal of molecular and cellular cardiology 1997;29(2):839-43.
1996: Keiko Yamauchi-Takihara; Hisao Hirota; Keita Kunisada; H Matsui; Yasushi Fujio; Tetsuya Taga; Tadamitsu Kishimoto
Roles of gp130 signaling pathways in cardiac myocytes: recent advances and implications for cardiovascular disease.
Journal of cardiac failure 1996;2(4 Suppl):S63-8.
1996: Keita Kunisada; Hisao Hirota; Yasushi Fujio; H Matsui; Y Tani; Keiko Yamauchi-Takihara; Tadamitsu Kishimoto
Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes.
Circulation 1996;94(10):2626-32.
1996: H Matsui; Yasushi Fujio; Keita Kunisada; Hisao Hirota; Keiko Yamauchi-Takihara
Leukemia inhibitory factor induces a hypertrophic response mediated by gp130 in murine cardiac myocytes.
Research communications in molecular pathology and pharmacology 1996;93(2):149-62.
1996: Keiko Yamauchi-Takihara; C Nakajima-Taniguchi; H Matsui; Yasushi Fujio; Keita Kunisada; Seiki Nagata; Tadamitsu Kishimoto
Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene.
Heart (British Cardiac Society) 1996;76(1):63-5.
1991: Ken'ichiro Hayashi; Yasushi Fujio; I Kato; Kenji Sobue
Structural and functional relationships between h- and l-caldesmons.
The Journal of biological chemistry 1991;266(1):355-61.
1989: Kenji Sobue; Yasushi Fujio
Significances of two different Mr caldesmons.
Advances in experimental medicine and biology 1989;255():325-35.
1988: Kenji Sobue; Yasushi Fujio; K Kanda
Tumor promoter induces reorganization of actin filaments and calspectin (fodrin or nonerythroid spectrin) in 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):482-6.