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Charles Abrams

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Anatomy

Physiology

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Yanfeng Wang; Ziqian Wang; John W Weisel; Tadayuki Yago; Helen Yin; Liang Zhao; John K Choi; John H Hartwig; Arkadiusz G Klopocki; Lurong Lian; Rustem I Litvinov; Rodger P McEver; Sang H Min; David W Schmidtke; Timothy J Stalker; Aae Suzuki; Charles S Abrams
Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.
Karen M Hook; Charles S Abrams
The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.
Karen M Hook; Charles S Abrams
Treatment options in heparin-induced thrombocytopenia.

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All Publications

2013: Yanfeng Wang; Ziqian Wang; John W Weisel; Tadayuki Yago; Helen Yin; Liang Zhao; John K Choi; John H Hartwig; Arkadiusz G Klopocki; Lurong Lian; Rustem I Litvinov; Rodger P McEver; Sang H Min; David W Schmidtke; Timothy J Stalker; Aae Suzuki; Charles S Abrams
Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.
Blood 2013;121(14):2743-52.
2012: Karen M Hook; Charles S Abrams
The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.
Clinical and translational science 2012;5(1):85-92.
2010: Karen M Hook; Charles S Abrams
Treatment options in heparin-induced thrombocytopenia.
Current opinion in hematology 2010;17(5):424-31.
2009: Sang H Min; Charles S Abrams
Why do phosphatidylinositol kinases have so many isoforms?
The Biochemical journal 2009;423(1):e5-8.
2009: Lurong Lian; Yanfeng Wang; Matthew Flick; John K Choi; Edward W Scott; Jay Degen; Mark A Lemmon; Charles S Abrams
Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis.
Blood 2009;113(15):3577-84.
2009: Ara Metjian; Charles S Abrams
New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin receptor-stimulating agents.
Biologics : targets & therapy 2009;3():499-513.
2008: Yanfeng Wang; Xinsheng Chen; Lurong Lian; Tang Tang; Timothy J Stalker; Takehiko Sasaki; Yasunori Kanaho; Lawrence F Brass; John K Choi; John H Hartwig; Charles S Abrams
Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14064-9.
2008: Natalie A. Bezman; Lurong Lian; Charles S Abrams; Lawrence F Brass; Mark L Kahn; Martha S Jordan; Gary A Koretzky
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.
The Journal of experimental medicine 2008;205(8):1775-88.
2008: Yanfeng Wang; Rustem I Litvinov; Xinsheng Chen; Tami L Bach; Lurong Lian; Brian Petrich; Susan J Monkley; Yasunori Kanaho; David R Critchley; Takehiko Sasaki; Morris J Birnbaum; John W Weisel; John Hartwig; Charles S Abrams
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.
The Journal of clinical investigation 2008;118(2):812-9.
2008: Ara Metjian; Charles S Abrams
New insights and therapeutics for immune-mediated thrombocytopenia.
Expert review of cardiovascular therapy 2008;6(1):71-84.
2007: Stephen K Richardson; Sarah B Newton; Tami L Bach; Jeanne B Budgin; Bernice M Benoit; Julie H Lin; Jessica S Yoon; Maria Wysocka; Charles S Abrams; Alain H Rook
Bexarotene blunts malignant T-cell chemotaxis in Sezary syndrome: reduction of chemokine receptor 4-positive lymphocytes and decreased chemotaxis to thymus and activation-regulated chemokine.
American journal of hematology 2007;82(9):792-7.
2007: Tami L Bach; Qing-Min Chen; Wesley T Kerr; Yanfeng Wang; Lurong Lian; John K Choi; Dianqing Wu; Marcelo G Kazanietz; Gary A Koretzky; Sally Zigmond; Charles S Abrams
Phospholipase cbeta is critical for T cell chemotaxis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2223-7.
2007: Daria V Babushok; Kazuhiko Ohshima; Eric M Ostertag; Xinsheng Chen; Yanfeng Wang; Prabhat K Mandal; Norihiro Okada; Charles S Abrams; Haig Kazazian
A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids.
Genome research 2007;17(8):1129-38.
2007: Yanfeng Wang; Lurong Lian; Jeffrey A Golden; Edward Morrisey; Charles S Abrams
PIP5KI gamma is required for cardiovascular and neuronal development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11748-53.
2007: Chinmay M Trivedi; Yang Luo; Zhan Yin; Maozhen Zhang; Wenting Zhu; Tao Wang; Thomas Floss; Martin Goettlicher; Patricia Ruiz Noppinger; Wolfgang Wurst; Victor A Ferrari; Charles S Abrams; Peter J Gruber; Jonathan A Epstein
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Nature medicine 2007;13(3):324-31.
2007: Tami L Bach; Wesley T Kerr; Yanfeng Wang; Eve Marie Bauman; Purnima Kine; Eileen L Whiteman; Renell S Morgan; Edward K Williamson; E Michael Ostap; Janis Burkhardt; Gary A Koretzky; Morris J Birnbaum; Charles S Abrams
PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.
Blood 2007;109(3):1147-55.
2006: Charles S Abrams
A new horizon for the treatment of heparin-induced thrombocytopenia?
Current hematology reports 2006;5(1):1-4.
2005: Charles S Abrams
Intracellular signaling in platelets.
Current opinion in hematology 2005;12(5):401-5.
2005: Lurong Lian; Yanfeng Wang; Julia Draznin; DON ESLIN; Joel S Bennett; Mortimer Poncz; Dianqing Wu; Charles S Abrams
The relative role of PLCbeta and PI3Kgamma in platelet activation.
Blood 2005;106(1):110-7.
2005: Eleanor S Pollak; Charles S Abrams
Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia.
Seminars in thoracic and cardiovascular surgery 2005;17(1):80-4.
2004: Seun-Ah Yang; Christopher L Carpenter; Charles S Abrams
Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets.
The Journal of biological chemistry 2004;279(40):42331-6.
2004: Alison W Loren; Charles S Abrams
Efficacy of HPA-1a (PlA1)-negative platelets in a patient with post-transfusion purpura.
American journal of hematology 2004;76(3):258-62.
2004: Charles S Abrams; Geno Merli
Atrial fibrillation and strokes: new drugs and a new attitude.
The American journal of managed care 2004;10(3 Suppl):S48-9.
2004: Charles S Abrams; Douglas B Cines
Thrombocytopenia after treatment with platelet glycoprotein IIb/IIIa inhibitors.
Current hematology reports 2004;3(2):143-7.
2004: Martin Carroll; Charles S Abrams
Signaling, drugs and apoptosis of myeloma cells.
Cancer biology & therapy 2004;3(2):195-6.
2003: Nicole A Aqui; Steven H Stein; Barbara A Konkle; Charles S Abrams; Frank J Strobl
Role of splenectomy in patients with refractory or relapsed thrombotic thrombocytopenic purpura.
Journal of clinical apheresis 2003;18(2):51-4.
2002: Charles S Abrams; Douglas B Cines
Platelet glycoprotein IIb/IIIa inhibitors and thrombocytopenia: possible link between platelet activation, autoimmunity and thrombosis.
Thrombosis and haemostasis 2002;88(6):888-9.
2002: Mark A Lemmon; Kathryn M Ferguson; Charles S Abrams
Pleckstrin homology domains and the cytoskeleton.
FEBS letters 2002;513(1):71-6.
2001: N E Chatah; Charles S Abrams
G-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phosphate 5-kinase I alpha by a Rac- and Rho-dependent pathway.
The Journal of biological chemistry 2001;276(36):34059-65.
2000: RL Roll; Eve Marie Bauman; Joel S Bennett; Charles S Abrams
Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway.
The Journal of cell biology 2000;150(6):1461-6.
1999: Alice Ma; Charles S Abrams
Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway.
The Journal of biological chemistry 1999;274(40):28730-5.
1999: Ara Metjian; RL Roll; Alice Ma; Charles S Abrams
Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus.
The Journal of biological chemistry 1999;274(39):27943-7.
1999: Alice Ma; Charles S Abrams
Pleckstrin homology domains and phospholipid-induced cytoskeletal reorganization.
Thrombosis and haemostasis 1999;82(2):399-406.
1999: M H Hu; Eve Marie Bauman; RL Roll; Newman M Yeilding; Charles S Abrams
Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement.
The Journal of biological chemistry 1999;274(31):21515-8.
1998: Alice Ma; Ara Metjian; S Bagrodia; S Taylor; Charles S Abrams
Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.
Molecular and cellular biology 1998;18(8):4744-51.
1997: Lawrence F Brass; David R Manning; Karen Cichowski; Charles S Abrams
Signaling through G proteins in platelets: to the integrins and beyond.
Thrombosis and haemostasis 1997;78(1):581-9.
1997: Alice Ma; Lawrence F Brass; Charles S Abrams
Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain.
The Journal of cell biology 1997;136(5):1071-9.
1996: Charles S Abrams; Jinsong Zhang; C P Downes; X w Tang; W Zhao; S E Rittenhouse
Phosphopleckstrin inhibits gbetagamma-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase.
The Journal of biological chemistry 1996;271(41):25192-7.
1995: Charles S Abrams; W Zhao; E Belmonte; Lawrence F Brass
Protein kinase C regulates pleckstrin by phosphorylation of sites adjacent to the N-terminal pleckstrin homology domain.
The Journal of biological chemistry 1995;270(40):23317-21.
1995: Charles S Abrams; H Wu; W Zhao; E Belmonte; D White; Lawrence F Brass
Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains.
The Journal of biological chemistry 1995;270(24):14485-92.
1995: M Molino; N Blanchard; E Belmonte; A P Tarver; Charles S Abrams; James A Hoxie; Chiara Cerletti; Lawrence F Brass
Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.
The Journal of biological chemistry 1995;270(19):11168-75.
1995: Charles S Abrams; W Zhao
SH3 domains specifically regulate kinase activity of expressed Src family proteins.
The Journal of biological chemistry 1995;270(1):333-9.
1994: Charles S Abrams; Y J Deng; B Steiner; T O'Toole; Sanford J Shattil
Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3.
The Journal of biological chemistry 1994;269(29):18781-8.
1994: R H Diamond; D E Cressman; T M Laz; Charles S Abrams; Rebecca Taub
PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth.
Molecular and cellular biology 1994;14(6):3752-62.
1992: Charles S Abrams; Z M Ruggeri; Rebecca Taub; James A Hoxie; Chandrasekaran Nagaswami; John W Weisel; Sanford J Shattil
Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen.
The Journal of biological chemistry 1992;267(4):2775-85.
1990: Charles S Abrams; N Ellison; A Z Budzynski; Sanford J Shattil
Direct detection of activated platelets and platelet-derived microparticles in humans.
Blood 1990;75(1):128-38.