Hiromi Fujiwara

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Morimoto Yasunari; Bian Yang; Gao Ping; Yashiro-Ohtani Yumi; Zhou Xu-Yu; Ono Shiro; Nakahara Hirokazu; Kogo Mikihiko; Hamaoka Toshiyuki; Fujiwara Hiromi
Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.
Hiraoka Shin-Ichiro; Takeuchi Noritami; Bian Yang; Nakahara Hirokazu; Kogo Mikihiko; Dunussi-Joannopoulos Kyriaki; Wolf Stanley; Ono Shiro; Fujiwara Hiromi
B7.2-Ig fusion proteins enhance IL-4-dependent differentiation of tumor-sensitized CD8+ cytotoxic T lymphocyte precursors.
Bian Yang; Hiraoka Shin-Ichiro; Tomura Michio; Zhou Xu-Yu; Yashiro-Ohtani Yumi; Mori Yoshiko; Shimizu Jun; Ono Shiro; Dunussi-Joannopoulos Kyriaki; Wolf Stanley; Fujiwara Hiromi
The capacity of the natural ligands for CD28 to drive IL-4 expression in naïve and antigen-primed CD4+ and CD8+ T cells.

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2005: Morimoto Yasunari; Bian Yang; Gao Ping; Yashiro-Ohtani Yumi; Zhou Xu-Yu; Ono Shiro; Nakahara Hirokazu; Kogo Mikihiko; Hamaoka Toshiyuki; Fujiwara Hiromi
Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development.
Journal of leukocyte biology 2005;78(3):753-61.
2005: Hiraoka Shin-Ichiro; Takeuchi Noritami; Bian Yang; Nakahara Hirokazu; Kogo Mikihiko; Dunussi-Joannopoulos Kyriaki; Wolf Stanley; Ono Shiro; Fujiwara Hiromi
B7.2-Ig fusion proteins enhance IL-4-dependent differentiation of tumor-sensitized CD8+ cytotoxic T lymphocyte precursors.
International immunology 2005;17(8):1071-9.
2005: Bian Yang; Hiraoka Shin-Ichiro; Tomura Michio; Zhou Xu-Yu; Yashiro-Ohtani Yumi; Mori Yoshiko; Shimizu Jun; Ono Shiro; Dunussi-Joannopoulos Kyriaki; Wolf Stanley; Fujiwara Hiromi
The capacity of the natural ligands for CD28 to drive IL-4 expression in naïve and antigen-primed CD4+ and CD8+ T cells.
International immunology 2005;17(1):73-83.
2004: Takeuchi Noritami; Hiraoka Shin-Ichiroh; Zhou Xu-Yu; Nagafuku Masakazu; Ono Shiro; Tsujimura Takahiro; Nakazawa Mitsuhiro; Yura Yoshiaki; Hamaoka Toshiyuki; Fujiwara Hiromi
Anti-HER-2/neu immune responses are induced before the development of clinical tumors but declined following tumorigenesis in HER-2/neu transgenic mice.
Cancer research 2004;64(20):7588-95.
2004: Yamaguchi Nobuya; Hiraoka Shin-ichiro; Mukai Takao; Takeuchi Noritami; Zhou Xu-Yu; Ono Shiro; Kogo Mikihiko; Dunussi-Joannopoulos Kyriaki; Ling Vincent; Wolf Stanley; Fujiwara Hiromi
Induction of tumor regression by administration of B7-Ig fusion proteins: mediation by type 2 CD8+ T cells and dependence on IL-4 production.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1347-54.
2004: Park Woong-Ryeon; Nakahira Masakiyo; Sugimoto Naotoshi; Bian Yang; Yashiro-Ohtani Yumi; Zhou Xu-Yu; Yang Yi-Fu; Hamaoka Toshiyuki; Fujiwara Hiromi
A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells.
International immunology 2004;16(2):295-302.
2003: Gao Ping; Zhou Xu-Yu; Yashiro-Ohtani Yumi; Yang Yi-Fu; Sugimoto Naotoshi; Ono Shiro; Nakanishi Tsuyoshi; Obika Satoshi; Imanishi Takeshi; Egawa Takeshi; Nagasawa Takashi; Fujiwara Hiromi; Hamaoka Toshiyuki
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3.
Journal of leukocyte biology 2003;73(2):273-80.
2003: Sugimoto Naotoshi; Nakahira Masakiyo; Ahn Hyun-Jong; Micallef Mark; Hamaoka Toshiyuki; Kurimoto Masashi; Fujiwara Hiromi
Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18.
European journal of immunology 2003;33(1):243-51.
2002: Uekusa Yasuhiro; Gao Ping; Yamaguchi Nobuya; Tomura Michio; Mukai Takao; Nakajima Chigusa; Iwasaki Masayuki; Takeuchi Noritame; Tsujimura Takahiro; Nakazawa Mitsuhiro; Fujiwara Hiromi; Hamaoka Toshiyuki
A role for endogenous IL-12 in tumor immunity: IL-12 is required for the acquisition of tumor-migratory capacity by T cells and the development of T cell-accepting capacity in tumor masses.
Journal of leukocyte biology 2002;72(5):864-73.
2002: Yang Yi-Fu; Mukai Takao; Gao Ping; Yamaguchi Nobuya; Ono Shiro; Iwaki Hiroshi; Obika Satoshi; Imanishi Takeshi; Tsujimura Takahiro; Hamaoka Toshiyuki; Fujiwara Hiromi
A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses.
European journal of immunology 2002;32(8):2124-32.
2002: Uekusa Yasuhiro; Yu Wen-Gong; Mukai Takao; Gao Ping; Yamaguchi Nobuya; Murai Masako; Matsushima Kouji; Obika Satoshi; Imanishi Takeshi; Higashibata Yuji; Nomura Shintaro; Kitamura Yukihiko; Fujiwara Hiromi; Hamaoka Toshiyuki
A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice.
Cancer research 2002;62(13):3751-8.
2002: Nakajima Chigusa; Mukai Takao; Yamaguchi Nobuya; Morimoto Yasunari; Park Woong-Ryeon; Iwasaki Masayuki; Gao Ping; Ono Shiro; Fujiwara Hiromi; Hamaoka Toshiyuki
Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation.
European journal of immunology 2002;32(6):1792-801.
2002: Zhou Xu-Yu; Yashiro-Ohtani Yumi; Nakahira Masakiyo; Park Woong Ryeon; Abe Ryo; Hamaoka Toshiyuki; Naramura Mayumi; Gu Hua; Fujiwara Hiromi
Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3847-54.
2002: Park Cheung-Seog; Yang Yi-Fu; Zhou Xu-Yu; Toyooka Kazuhito; Yashiro-Ohtani Yumi; Park Woong-Ryeon; Tomura Michio; Tai Xu-Guang; Hamaoka Toshiyuki; Fujiwara Hiromi
Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line.
International immunology 2002;14(3):259-66.
2002: Nakahira Masakiyo; Ahn Hyun-Jong; Park Woong-Ryeon; Gao Ping; Tomura Michio; Park Cheung-Seog; Hamaoka Toshiyuki; Ohta Tsunetaka; Kurimoto Masashi; Fujiwara Hiromi
Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1146-53.
2001: Iwasaki M; Mukai T; Nakajima C; Yang Y F; Gao P; Yamaguchi N; Tomura M; Fujiwara H; Hamaoka T
A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):6877-83.
2001: Yang Y F; Tomura M; Iwasaki M; Ono S; Zou J P; Uno K; Shearer G M; Fujiwara H; Hamaoka T
IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4+ and CD8+ T cells.
Journal of clinical immunology 2001;21(6):402-9.
2001: Mukai T; Iwasaki M; Gao P; Tomura M; Yashiro-Ohtani Y; Ono S; Murai M; Matsushima K; Kurimoto M; Kogo M; Matsuya T; Fujiwara H; Hamaoka T
IL-12 plays a pivotal role in LFA-1-mediated T cell adhesiveness by up-regulation of CCR5 expression.
Journal of leukocyte biology 2001;70(3):422-30.
2001: Iwasaki M; Mukai T; Gao P; Park W R; Nakajima C; Tomura M; Fujiwara H; Hamaoka T
A critical role for IL-12 in CCR5 induction on T cell receptor-triggered mouse CD4(+) and CD8(+) T cells.
European journal of immunology 2001;31(8):2411-20.
2001: Nakahira M; Tomura M; Iwasaki M; Ahn H J; Bian Y; Hamaoka T; Ohta T; Kurimoto M; Fujiwara H
An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1306-12.
2001: Park W R; Park C S; Tomura M; Ahn H J; Nakahira Y; Iwasaki M; Gao P; Abe R; Hamaoka T; Fujiwara H
CD28 costimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells.
European journal of immunology 2001;31(5):1456-64.
2001: Fujiwara H; Hamaoka T
Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression.
International immunopharmacology 2001;1(4):613-23.
2001: Nakajima C; Uekusa Y; Iwasaki M; Yamaguchi N; Mukai T; Gao P; Tomura M; Ono S; Tsujimura T; Fujiwara H; Hamaoka T
A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice.
Cancer research 2001;61(8):3399-405.
2001: Yang Y F; Tomura M; Iwasaki M; Mukai T; Gao P; Ono S; Zou J P; Shearer G M; Fujiwara H; Hamaoka T
IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells.
Journal of clinical immunology 2001;21(2):116-25.
2001: Tanaka T; Katada Y; Higa S; Fujiwara H; Wang W; Saeki Y; Ohshima S; Okuda Y; Suemura M; Kishimoto T
Enhancement of T helper2 response in the absence of interleukin (IL-)6; an inhibition of IL-4-mediated T helper2 cell differentiation by IL-6.
Cytokine 2001;13(4):193-201.
2001: Su W; Ito T; Oyama T; Kitagawa T; Yamori T; Fujiwara H; Matsuda H
The direct effect of IL-12 on tumor cells: IL-12 acts directly on tumor cells to activate NF-kappaB and enhance IFN-gamma-mediated STAT1 phosphorylation.
Biochemical and biophysical research communications 2001;280(2):503-12.
2000: Yang Y F; Tomura M; Ono S; Hamaoka T; Fujiwara H
Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells.
International immunology 2000;12(12):1669-75.
2000: Gao P; Uekusa Y; Nakajima C; Iwasaki M; Nakahira M; Yang Y F; Ono S; Tsujimura T; Fujiwara H; Hamaoka T
Tumor vaccination that enhances antitumor T-cell responses does not inhibit the growth of established tumors even in combination with interleukin-12 treatment: the importance of inducing intratumoral T-cell migration.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(6):643-53.
2000: Park C S; Park W R; Sugimoto N; Nakahira M; Ahn H J; Hamaoka T; Ohta T; Kurimoto M; Fujiwara H
Differential effects of N-acetyl-l-cysteine on IL-2- vs IL-12-driven proliferation of a T cell clone: implications for distinct signalling pathways.
Cytokine 2000;12(9):1419-22.
2000: Nakanishi T; Hayashi A; Kunisawa J; Tsutsumi Y; Tanaka K; Yashiro-Ohtani Y; Nakanishi M; Fujiwara H; Hamaoka T; Mayumi T
Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway.
European journal of immunology 2000;30(6):1740-7.
2000: Iwasaki M; Yu W G; Uekusa Y; Nakajima C; Yang Y F; Gao P; Wijesuriya R; Fujiwara H; Hamaoka T
Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models.
International immunology 2000;12(5):701-9.
2000: Uekusa Y; Ogawa M; Gao P; Iwasaki M; Ono S; Tsujimura T; Nakazawa M; Sakuda M; Clancy B; Fujiwara H; Hamaoka T
The development of peritumoral stroma required for IL-12 induced tumor regression depends on the T cell/IFN-gamma-involving host-tumor interaction.
International journal of oncology 2000;16(4):805-14.
2000: Zhou X Y; Yashiro-Ohtani Y; Toyo-Oka K; Park C S; Tai X G; Hamaoka T; Fujiwara H
CD5 costimulation up-regulates the signaling to extracellular signal-regulated kinase activation in CD4+CD8+ thymocytes and supports their differentiation to the CD4 lineage.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1260-8.
2000: Yashiro-Ohtani Y; Zhou X Y; Toyo-Oka K; Tai X G; Park C S; Hamaoka T; Abe R; Miyake K; Fujiwara H
Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1251-9.
1999: Toyo-oka K; Yashiro-Ohtani Y; Park C S; Tai X G; Miyake K; Hamaoka T; Fujiwara H
Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association.
International immunology 1999;11(12):2043-52.
1999: Hayashi A; Nakanishi T; Kunisawa J; Kondoh M; Imazu S; Tsutsumi Y; Tanaka K; Fujiwara H; Hamaoka T; Mayumi T
A novel vaccine delivery system using immunopotentiating fusogenic liposomes.
Biochemical and biophysical research communications 1999;261(3):824-8.
1999: Tomura M; Yu W G; Ahn H J; Yamashita M; Yang Y F; Ono S; Hamaoka T; Kawano T; Taniguchi M; Koezuka Y; Fujiwara H
A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):93-101.
1999: Ogawa M; Umehara K; Yu W G; Uekusa Y; Nakajima C; Tsujimura T; Kubo T; Fujiwara H; Hamaoka T
A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression.
Cancer research 1999;59(7):1531-8.
1998: Ahn H J; Tomura M; Yu W G; Iwasaki M; Park W R; Hamaoka T; Fujiwara H
Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):5893-900.
1998: Toyooka K; Tai X G; Park C S; Yashiro Y; Hamaoka T; Fujiwara H
A caspase inhibitor protects thymocytes from diverse signal-mediated apoptosis but not from clonal deletion in fetal thymus organ culture.
Immunology letters 1998;63(2):83-9.
1998: Wijesuriya R; Maruo S; Zou J P; Ogawa M; Umehara K; Yamashita M; Ono S; Fujiwara H; Hamaoka T
B cell-mediated down-regulation of IFN-gamma and IL-12 production induced during anti-tumor immune responses in the tumor-bearing state.
International immunology 1998;10(8):1057-65.
1998: Park C S; Yashiro Y; Tai X G; Toyo-oka K; Hamaoka T; Yagita H; Okumura K; Neben S; Fujiwara H
Differential involvement of a Fas-CPP32-like protease pathway in apoptosis of TCR/CD9-costimulated, naive T cells and TCR-restimulated, activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5790-6.
1998: Ogawa M; Yu W G; Umehara K; Iwasaki M; Wijesuriya R; Tsujimura T; Kubo T; Fujiwara H; Hamaoka T
Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression.
Cancer research 1998;58(11):2426-32.
1998: Tomura M; Zhou X Y; Maruo S; Ahn H J; Hamaoka T; Okamura H; Nakanishi K; Tanimoto T; Kurimoto M; Fujiwara H
A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4738-46.
1998: Tomura M; Maruo S; Mu J; Zhou X Y; Ahn H J; Hamaoka T; Okamura H; Nakanishi K; Clark S; Kurimoto M; Fujiwara H
Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3759-65.
1998: Yashiro Y; Tai X G; Toyo-oka K; Park C S; Abe R; Hamaoka T; Kobayashi M; Neben S; Fujiwara H
A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory molecules.
European journal of immunology 1998;28(3):926-35.
1997: Nakanishi T; Kunisawa J; Hayashi A; Tsutsumi Y; Kubo K; Nakagawa S; Fujiwara H; Hamaoka T; Mayumi T
Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins.
Biochemical and biophysical research communications 1997;240(3):793-7.
1997: Tai X G; Toyooka K; Yashiro Y; Abe R; Park C S; Hamaoka T; Kobayashi M; Neben S; Fujiwara H
CD9-mediated costimulation of TCR-triggered naive T cells leads to activation followed by apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3799-807.
1997: Yu W G; Ogawa M; Mu J; Umehara K; Tsujimura T; Fujiwara H; Hamaoka T
IL-12-induced tumor regression correlates with in situ activity of IFN-gamma produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways.
Journal of leukocyte biology 1997;62(4):450-7.
1997: Tomura M; Nakatani I; Murachi M; Tai X G; Toyo-oka K; Fujiwara H
Suppression of allograft responses induced by interleukin-6, which selectively modulates interferon-gamma but not interleukin-2 production.
Transplantation 1997;64(5):757-63.
1997: Yang Y F; Zou J P; Mu J; Wijesuriya R; Ono S; Walunas T; Bluestone J; Fujiwara H; Hamaoka T
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages.
Cancer research 1997;57(18):4036-41.
1997: Tsutsui T; Mu J; Ogawa M; Yu W G; Suda T; Nagaga S; Saji F; Murata Y; Fujiwara H; Hamaoka T
Administration of IL-12 induces a CD3+ CD4- CD8- B220+ lymphoid population capable of eliciting cytolysis against Fas-positive tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2599-605.
1997: Ahn H J; Maruo S; Tomura M; Mu J; Hamaoka T; Nakanishi K; Clark S; Kurimoto M; Okamura H; Fujiwara H
A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2125-31.
1997: Toyo-oka K; Tai X G; Yashiro Y; Ahn H J; Abe R; Hamaoka T; Kobayashi M; Neben S; Fujiwara H
Synergy between CD28 and CD9 costimulation for naive T-cell activation.
Immunology letters 1997;58(1):19-23.
1997: Ogawa M; Tsutsui T; Zou J P; Mu J; Wijesuriya R; Yu W G; Herrmann S; Kubo T; Fujiwara H; Hamaoka T
Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.
Cancer research 1997;57(11):2216-22.
1997: Tai X G; Toyo-oka K; Yamamoto N; Yashiro Y; Mu J; Hamaoka T; Fujiwara H
Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4696-703.
1997: Takenaka H; Maruo S; Yamamoto N; Wysocka M; Ono S; Kobayashi M; Yagita H; Okumura K; Hamaoka T; Trinchieri G; Fujiwara H
Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4.
Journal of leukocyte biology 1997;61(1):80-7.
1997: Maruo S; Oh-hora M; Ahn H J; Ono S; Wysocka M; Kaneko Y; Yagita H; Okumura K; Kikutani H; Kishimoto T; Kobayashi M; Hamaoka T; Trinchieri G; Fujiwara H
B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):120-6.
1996: Mu J; Abe Y; Tsutsui T; Yamamoto N; Tai X G; Niwa O; Tsujimura T; Sato B; Terano H; Fujiwara H; Hamaoka T
Inhibition of growth and metastasis of ovarian carcinoma by administering a drug capable of interfering with vascular endothelial growth factor activity.
Japanese journal of cancer research : Gann 1996;87(9):963-71.
1996: Tai X G; Yashiro Y; Abe R; Toyooka K; Wood C R; Morris J; Long A; Ono S; Kobayashi M; Hamaoka T; Neben S; Fujiwara H
A role for CD9 molecules in T cell activation.
The Journal of experimental medicine 1996;184(2):753-8.
1996: Yu W G; Yamamoto N; Takenaka H; Mu J; Tai X G; Zou J P; Ogawa M; Tsutsui T; Wijesuriya R; Yoshida R; Herrmann S; Fujiwara H; Hamaoka T
Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12.
International immunology 1996;8(6):855-65.
1996: Maruo S; Toyo-oka K; Oh-hora M; Tai X G; Iwata H; Takenaka H; Yamada S; Ono S; Hamaoka T; Kobayashi M; Wysocka M; Trinchieri G; Fujiwara H
IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(5):1748-55.
1996: Toyooka K; Maruo S; Iwahori T; Yamamoto N; Tai X G; Abe R; Takahama Y; Murakami M; Uede T; Hamaoka T; Fujiwara H
CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism.
International immunology 1996;8(2):159-69.
1996: Yoshida K; Taga T; Saito M; Suematsu S; Kumanogoh A; Tanaka T; Fujiwara H; Hirata M; Yamagami T; Nakahata T; Hirabayashi T; Yoneda Y; Tanaka K; Wang W Z; Mori C; Shiota K; Yoshida N; Kishimoto T
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):407-11.
1996: Yasui T; Fujiwara H; Kamanaka M; Kawabe T; Yoshida N; Kishimoto T; Kikutani H
The roles of CD40 and CD23 in IgE regulation.
Advances in experimental medicine and biology 1996;409():349-54.
1995: Mu J; Zou J P; Yamamoto N; Tsutsui T; Tai X G; Kobayashi M; Herrmann S; Fujiwara H; Hamaoka T
Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.
Cancer research 1995;55(19):4404-8.
1995: Fujiwara H; Zou J P; Herrmann S; Hamaoka T
A sequence of cellular and molecular events involved in IL12-induced tumour regression.
Research in immunology 1995;146(7-8):638-44.
1995: Zou J P; Yamamoto N; Fujii T; Takenaka H; Kobayashi M; Herrmann S H; Wolf S F; Fujiwara H; Hamaoka T
Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-gamma production by anti-tumor T cells.
International immunology 1995;7(7):1135-45.
1995: Noda S; Nagata-Narumiya T; Kosugi A; Narumiya S; Ra C; Fujiwara H; Hamaoka T
Do structural changes of T cell receptor complex occur in tumor-bearing state?
Japanese journal of cancer research : Gann 1995;86(4):383-94.
1995: Fujiwara H; Hamaoka T
Regulatory mechanisms of antitumor T cell responses in the tumor-bearing state.
Immunologic research 1995;14(4):271-91.
1994: Kawabe T; Naka T; Yoshida K; Tanaka T; Fujiwara H; Suematsu S; Yoshida N; Kishimoto T; Kikutani H
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
Immunity 1994;1(3):167-78.
1994: Iwata H; Nagano T; Toyo-oka K; Hirose H; Hamaoka T; Fujiwara H
Suppression of allograft responses by combining alloantigen-specific i.v. presensitization with suboptimal doses of FK 506 or rapamycin.
Transplantation proceedings 1994;26(2):851-4.
1994: Iwata H; Nagano T; Toyo-oka K; Hirose H; Hamaoka T; Fujiwara H
Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin.
International immunology 1994;6(1):93-9.
1994: Tai X G; Saitoh Y; Satoh T; Yamamoto N; Kita Y; Takenaka H; Yu W G; Zou J P; Hamaoka T; Fujiwara H
Thymic stromal cells eliminate T cells stimulated with antigen plus stromal Ia molecules through their cross-talk involving the production of interferon-gamma and nitric oxide.
Thymus 1994;24(1):41-56.
1993: Nagata T; Zou J P; Yamamoto N; Ono S; Fujiwara H; Hamaoka T
Suppression of anti-tumor CD4+ T cell responsiveness in the tumor-bearing state and its recovery in in vitro culture free of tumor burden.
Japanese journal of cancer research : Gann 1993;84(11):1181-9.
1993: Iwata H; Kitagawa S; Sato S; Kosugi A; Hirose H; Hamaoka T; Shearer G M; Fujiwara H
Suppression of allograft responses by combining donor alloantigen-specific intravenous presensitization with suboptimal doses of FK506.
Transplantation 1993;56(1):173-80.
1993: Tai X G; Kita Y; Toyooka K; Hamaoka T; Fujiwara H
Thymic stroma-derived T-cell inhibitory factor (TSTIF). 2: TSTIF acts on the antigen-presenting cell to inhibit antigen-stimulated T-cell proliferation.
Thymus 1993;21(4):247-58.
1993: Li X F; Takiuchi H; Zou J P; Katagiri T; Yamamoto N; Nagata T; Ono S; Fujiwara H; Hamaoka T
Transforming growth factor-beta (TGF-beta)-mediated immunosuppression in the tumor-bearing state: enhanced production of TGF-beta and a progressive increase in TGF-beta susceptibility of anti-tumor CD4+ T cell function.
Japanese journal of cancer research : Gann 1993;84(3):315-25.
1992: Kosugi A; Weissman A M; Ogata M; Hamaoka T; Fujiwara H
Instability of assembled T-cell receptor complex that is associated with rapid degradation of zeta chains in immature CD4+CD8+ thymocytes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9494-8.
1992: Takiuchi H; Tada T; Li X F; Ogata M; Ikeda T; Fujimoto S; Fujiwara H; Hamaoka T
Particular types of tumor cells have the capacity to convert transforming growth factor beta from a latent to an active form.
Cancer research 1992;52(20):5641-6.
1992: Shimizu J; Suda T; Katagiri T; Fujiwara H; Hamaoka T
Tumor-specific T cell lines: capacity to proliferate and produce interleukin 2 in response to various forms of tumor antigens.
Japanese journal of cancer research : Gann 1992;83(2):184-93.
1992: Hori S; Kitagawa S; Iwata H; Ochiai T; Isono K; Hamaoka T; Fujiwara H
Cell-cell interaction in graft rejection responses: induction of anti-allo-class I H-2 tolerance is prevented by immune responses against allo-class II H-2 antigens coexpressed on tolerogen.
The Journal of experimental medicine 1992;175(1):99-109.
1992: Zou J P; Shimizu J; Ikegame K; Yamamoto N; Ono S; Fujiwara H; Hamaoka T
Tumor-bearing mice exhibit a progressive increase in tumor antigen-presenting cell function and a reciprocal decrease in tumor antigen-responsive CD4+ T cell activity.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(2):648-55.
1992: Zou J P; Shimizu J; Ikegame K; Takiuchi H; Fujiwara H; Hamaoka T
Tumor-immunotherapy with the use of tumor-antigen-pulsed antigen-presenting cells.
Cancer immunology, immunotherapy : CII 1992;35(1):1-6.
1991: Sato S; Iwata H; Kitagawa S; Kokudo S; Okuno K; Hamaoka T; Fujiwara H
The lymphoid cell populations required for induction of tolerance of different subsets of alloantigen-reactive T cells.
Transplantation 1991;52(5):862-7.
1991: Kitagawa S; Iwata H; Sato S; Shimizu J; Hamaoka T; Fujiwara H
Heterogenous graft rejection pathways in class I major histocompatibility complex-disparate combinations and their differential susceptibility to immunomodulation induced by intravenous presensitization with relevant alloantigens.
The Journal of experimental medicine 1991;174(3):571-81.
1991: Nagamine J; Takeda K; Tatsumi Y; Ogata M; Miyake K; Hamaoka T; Fujiwara H
Role of a thymic stromal cell clone in inducing the stage-specific differentiation of various subpopulations of double negative thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1147-52.
1991: Kimura K; Matsubara H; Sogoh S; Kita Y; Sakata T; Nishitani Y; Watanabe S; Hamaoka T; Fujiwara H
Role of glycosaminoglycans in the regulation of T cell proliferation induced by thymic stroma-derived T cell growth factor.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2618-24.
1991: Kitagawa S; Sato S; Azuma T; Shimizu J; Hamaoka T; Fujiwara H
Heterogeneity of CD4+ T cells involved in anti-allo-class I H-2 immune responses. Functional discrimination between the major proliferating cells and helper cells assisting cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2513-21.
1991: Shimizu J; Zou J P; Ikegame K; Katagiri T; Fujiwara H; Hamaoka T
Evidence for the functional binding in vivo of tumor rejection antigens to antigen-presenting cells in tumor-bearing hosts.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1708-14.
1991: Shimizu J; Zou J P; Ikegame K; Fujiwara H; Hamaoka T
Antigen-presenting cells constitutively bind tumor antigens in the tumor-bearing state in vivo to construct an effective immunogenic unit.
Japanese journal of cancer research : Gann 1991;82(3):262-5.
1991: Kitagawa S; Sato S; Hori S; Hamaoka T; Fujiwara H
Cell-cell interaction in graft-rejection responses: breakdown of tolerance to allo-class I H-2 antigens by helper T cells against other histocompatibility antigens simultaneously expressed on a graft.
Transplantation proceedings 1991;23(1 Pt 1):96-8.
1991: Sato S; Kitagawa S; Hori S; Azuma T; Hamaoka T; Fujiwara H
Role of the thymus in repopulating alloantigen-reactive T cells after its functional elimination by intravenous presensitization with allogeneic cells.
Transplantation proceedings 1991;23(1 Pt 1):152-4.
1991: Tada T; Ohzeki S; Utsumi K; Takiuchi H; Muramatsu M; Li X F; Shimizu J; Fujiwara H; Hamaoka T
Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(3):1077-82.
1990: Fujiwara H; Ogata M; Mizushima Y; Tatsumi Y; Takai Y; Hamaoka T
Proliferation and differentiation of immature thymocytes induced by a thymic stromal cell clone.
Thymus 1990;16(3-4):159-72.
1990: Kitagawa S; Sato S; Hori S; Hamaoka T; Fujiwara H
Induction of anti-allo-class I H-2 tolerance by inactivation of CD8+ helper T cells, and reversal of tolerance through introduction of third-party helper T cells.
The Journal of experimental medicine 1990;172(1):105-13.
1990: Kosaka H; Matsubara H; Sogoh S; Ogata M; Hamaoka T; Fujiwara H
An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination.
The Journal of experimental medicine 1990;172(1):395-8.
1990: Utsumi K; Takai Y; Tada T; Ohzeki S; Fujiwara H; Hamaoka T
Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):397-403.
1990: Kitagawa S; Sato S; Azuma T; Hori S; Hamaoka T; Fujiwara H
Requirement of the thymus for the recovery of anti-alloantigen helper T cells from tolerance induced by intravenous presensitization with allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(11):4139-46.
1990: Kosaka H; Ogata M; Sano H; Sakuma S; Mizushima Y; Nakamura E; Teraoka H; Hamaoka T; Fujiwara H
Thymic stroma-derived T cell growth factor (TSTGF): III. Its ability to promote T cell proliferation without stimulating interleukin 2- or 4-dependent autocrine mechanism.
Journal of leukocyte biology 1990;47(2):121-8.
1990: Tada T; Sano H; Sato S; Shima J; Fujiwara H; Hamaoka T
Immune dysfunction expressed selectively on L3T4+ T cells in the tumor-bearing state.
Journal of leukocyte biology 1990;47(2):149-57.
1990: Sugihara S; Maruo S; Tsujimura T; Tarutani O; Kohno Y; Hamaoka T; Fujiwara H
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. III. Analysis of regulatory cells suppressing the induction of thyroiditis.
International immunology 1990;2(4):343-51.
1989: Sano S; Kiyotaki C; Tatsumi Y; Fujiwara H; Hamaoka T
Cytotoxic T lymphocyte unresponsiveness induced by prolonged treatment with immobilized anti-CD3 antibody. Association of impairment of cytolytic activity with temporary depletion of intracellular protein kinase C.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2797-805.
1989: Sugihara S; Maruo S; Tada T; Tsujimura T; Kohno Y; Hamaoka T; Fujiwara H
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. II. Immunohistochemical studies on the thyroiditis lesion.
Regional immunology 1989;2(6):345-54.
1989: Hori S; Sato S; Kitagawa S; Azuma T; Kokudo S; Hamaoka T; Fujiwara H
Tolerance induction of allo-class II H-2 antigen-reactive L3T4+ helper T cells and prolonged survival of the corresponding class II H-2-disparate skin graft.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(5):1447-52.
1989: Suda T; Shimizu J; Muramatsu M; Kimura K; Yoshida T O; Fukami Y; Fujiwara H; Hamaoka T
The tumor rejection antigen separated from Rous sarcoma virus-induced murine fibrosarcoma exhibits a molecular weight of approximately 60 kD but differs from functional pp60src.
Japanese journal of cancer research : Gann 1989;80(9):879-86.
1989: Azuma T; Sato S; Kitagawa S; Hori S; Kokudo S; Hamaoka T; Fujiwara H
Tolerance induction of allo-class I H-2 antigen-reactive Lyt-2+ helper T cells and prolonged survival of the corresponding class I H-2-disparate skin graft.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):1-8.
1989: Kosaka H; Ogata M; Hikita I; Maruo S; Sugihara S; Matsubara H; Takai Y; Hamaoka T; Fujiwara H
Model for clonal elimination in the thymus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3773-7.
1989: Fujiwara H; Suda T; Shimizu J; Muramatsu M; Kimura K; Hamaoka T
[Biochemical characterization of tumor rejection antigen (TRA) and genetic control in anti-TRA immune responses]
Gan to kagaku ryoho. Cancer & chemotherapy 1989;16(3 Pt 2):646-52.
1989: Mizushima Y; Saitoh M; Ogata M; Kosaka H; Tatsumi Y; Kiyotaki C; Hamaoka T; Fujiwara H
Thymic stroma-derived T cell growth factor (TSTGF). IV. Capacity of TSTGF to promote the growth of L3T4- Lyt-2- thymocytes by synergy with phorbol myristate acetate or various IL.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(4):1195-202.
1989: Shimizu J; Suda T; Yoshioka T; Kosugi A; Fujiwara H; Hamaoka T
Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(3):1053-9.
1989: Ogata M; Matsubara H; Takai Y; Kosaka H; Katagiri T; Sano H; Ishimura K; Fujita H; Hamaoka T; Fujiwara H
Capacities of a newly established thymic stromal cell clone to express Ia antigens and to produce interleukin-6, colony-stimulating factor, and thymic stroma-derived T-cell growth factor.
Journal of leukocyte biology 1989;45(1):69-78.
1988: Mori M; Tajima K; Miyagawa J; Shimizu M; Mashita K; Sugihara S; Hamaoka T; Fujiwara H; Tarui S
Release of 3,5,3'-triiodothyronine, thyroxine and thyroglobulin from TSH-stimulated mouse thyroids in the perifusion system.
Experientia 1988;44(9):766-8.
1988: Sato S; Ogata M; Sano H; Mizushima Y; Muramatsu M; Doi H; Itoh T; Hamaoka T; Fujiwara H
Thymic stroma-derived T-cell growth factor (TSTGF): II. Biochemical and functional characterization.
Journal of leukocyte biology 1988;44(3):149-57.
1988: Sato S; Azuma T; Shimizu J; Shima J; Kitagawa S; Hamaoka T; Fujiwara H
Property of class I H-2 alloantigen-reactive Lyt-2+ helper T cell subset. Abrogation of its proliferative and IL-2-producing capacities by intravenous injection of class I H-2-disparate allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):721-7.
1988: Suda T; Sano S; Hori S; Azuma T; Tateishi N; Hamaoka T; Fujiwara H
Prevention of suppression of alloreactive capacity following intravenous injection of neuraminidase-treated allogeneic cells by co-injection of agents competing for asialoglycoprotein receptor.
Regional immunology 1988;1(1):24-31.
1988: Sano H; Sato S; Shima J; Tada T; Fujiwara H; Hamaoka T
Selective suppression of the generation of anti-tumor L3T4+ but not of Lyt-2+ T cell-mediated immunity in the tumor-bearing state.
Japanese journal of cancer research : Gann 1988;79(7):857-65.
1988: Sugihara S; Izumi Y; Yoshioka T; Yagi H; Tsujimura T; Tarutani O; Kohno Y; Murakami S; Hamaoka T; Fujiwara H
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(1):105-13.
1988: Suda T; Shimizu J; Mizushima Y; Fujiwara H; Hamaoka T
Separation of the tumor rejection antigen of Rous sarcoma virus-induced murine fibrosarcoma.
Japanese journal of cancer research : Gann 1988;79(3):365-74.
1988: Sato S; Qian J H; Kokudo S; Ikegami R; Suda T; Hamaoka T; Fujiwara H
Studies on the induction of tolerance to alloantigens. III. Induction of antibodies directed against alloantigen-specific delayed-type hypersensitivity T cells by a single injection of allogeneic lymphocytes via portal venous route.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(3):717-22.
1988: Sakamoto K; Yoshioka T; Shimizu J; Sato S; Nakajima H; Fujiwara H; Hamaoka T
Mechanisms for recognition of tumor antigens and mediation of anti-tumor effect by noncytolytic Lyt-2+ T cell subset.
Japanese journal of cancer research : Gann 1988;79(1):99-108.
1988: Yoshioka T; Sato S; Ogata M; Sakamoto K; Sano H; Shima J; Yamamoto H; Fujiwara H; Hamaoka T
Mediation of in vivo tumor-neutralizing activity by Lyt-2+ as well as L3T4+ T cell subsets.
Japanese journal of cancer research : Gann 1988;79(1):91-8.
1988: Kokudo S; Sato S; Qian J H; Wada K; Ikegami R; Hamaoka T; Fujiwara H
Tolerance induction of alloreactivity by portal venous inoculation with allogeneic cells followed by the injection of cyclophosphamide. II. Cellular and molecular mechanisms underlying tolerance.
Microbiology and immunology 1988;32(3):283-92.
1988: Hamaoka T; Shimizu J; Suda T; Fujiwara H
Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.
Princess Takamatsu symposia 1988;19():265-75.
1988: Fujiwara H; Ogata M; Mizushima Y; Kosaka H; Matsubara H; Takai Y; Hamaoka T
Thymic stroma-derived T cell growth factor: its role in the growth of immature thymocytes and T cell repertoire selection.
Princess Takamatsu symposia 1988;19():115-26.
1988: Sakamoto K; Nakajima H; Shimizu J; Katagiri T; Kiyotaki C; Fujiwara H; Hamaoka T
The mode of recognition of tumor antigens by noncytolytic-type antitumor T cells: role of antigen-presenting cells and their surface class I and class II H-2 molecules.
Cancer immunology, immunotherapy : CII 1988;27(3):261-6.
1988: Shima J; Yoshioka T; Nakajima H; Fujiwara H; Hamaoka T
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. III. Eradication of disseminated murine chronic leukemia cells by utilizing MDP hapten-reactive helper T-cell activity.
Cancer immunology, immunotherapy : CII 1988;26(1):43-7.
1987: Sano S; Suda T; Qian J H; Sato S; Ikegami R; Hamaoka T; Fujiwara H
Abrogation of the capacity of delayed-type hypersensitivity responses to alloantigens by intravenous injection of neuraminidase-treated allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(11):3652-9.
1987: Kosugi A; Yoshioka T; Suda T; Sano H; Takahama Y; Fujiwara H; Hamaoka T
The activation of L3T4+ helper T cells assisting the generation of anti-tumor Lyt-2+ cytotoxic T lymphocytes: requirement of Ia-positive antigen-presenting cells for processing and presentation of tumor antigens.
Journal of leukocyte biology 1987;42(6):632-41.
1987: Ogata M; Sato S; Sano H; Hamaoka T; Doi H; Nakanishi K; Asano Y; Itoh T; Fujiwara H
Thymic stroma-derived T cell growth factor (TSTGF). I. Functional distinction of TSTGF from interleukins 2 and 4 and its preferential growth-promoting effect on helper T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2675-82.
1987: Kokudo S; Qian J H; Fujiwara H; Hamaoka T
Suppressive effect of portal venous inoculation with tumor cells on the anti-tumor immune potential.
Japanese journal of cancer research : Gann 1987;78(9):946-51.
1987: Qian J H; Kokudo S; Sato S; Hamaoka T; Fujiwara H
Tolerance induction of alloreactivity by portal venous inoculation with allogeneic cells followed by the injection of cyclophosphamide. I. Specific suppression of alloreactive cytotoxic and delayed-type hypersensitivity responses as well as allograft rejection.
Transplantation 1987;43(4):538-43.
1987: Shima J; Yoshioka T; Kosugi A; Ogata M; Fujiwara H; Hamaoka T; Ueda S; Kato S
Differential ability of tumor-unique and cross-reactive antigen(s) on two murine hepatoma cell lines to induce Lyt-1+2- T cells responsible for in vivo protective immunity.
Biken journal 1987;30(1):1-8.
1987: Sano S; Izumi Y; Sugihara S; Nakajima H; Fujiwara H; Hamaoka T
The generation of tumor-specific in vivo protective immunity in the tumor mass from mice rendered tolerant to tumor antigens.
Cancer immunology, immunotherapy : CII 1987;25(2):105-10.
1987: Shimizu J; Ogata M; Qian J H; Sato S; Kokudo S; Hamaoka T; Fujiwara H
Immunogenetic analysis of tolerance induction in anti-alloantigen delayed type hypersensitivity responses by portal venous pre-inoculation with allogeneic cells.
Microbiology and immunology 1987;31(4):367-74.
1987: Nakajima H; Izumi Y; Sugihara S; Satoh Y; Isumi S; Gotoh T; Fujiwara H; Hamaoka T
Studies on macrophage-activating factor (MAF) in antitumor immune responses. II. Molecular characterization of MAF produced by the tumor-immune Lyt-1+2- T cell subset.
Cancer immunology, immunotherapy : CII 1987;25(3):201-8.
1987: Sano H; Kosugi A; Sano S; Fujiwara H; Hamaoka T
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. II. Establishment of tumor-specific immunotherapy models utilizing MDP hapten-reactive helper T cell activity.
Cancer immunology, immunotherapy : CII 1987;25(3):180-4.
1987: Fujiwara H; Shima J; Sano H; Kosugi A; Nakajima H; Hamaoka T
Tumor-specific immunotherapy by active immunization with haptenic muramyl dipeptide derivative-coupled tumor cells.
Progress in clinical and biological research 1987;244():335-44.
1986: Kosugi A; Shima J; Sano H; Ogata M; Kusama T; Fujiwara H; Hamaoka T
Cross-reactivity between haptenic muramyl di- or tripeptide derivatives and Mycobacterium bovis BCG: potential application for enhancing tumor immunity.
Infection and immunity 1986;54(3):768-73.
1986: Fujiwara H; Yoshioka T; Shima J; Kosugi A; Itoh K; Hamaoka T
Helper T cells against tumor-associated antigens (TAA): preferential induction of helper T cell activities involved in anti-TAA cytotoxic T lymphocyte and antibody responses.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(7):2715-9.
1986: Fujiwara H; Qian J H; Satoh S; Kokudo S; Ikegami R; Hamaoka T
Studies on the induction of tolerance to alloantigens. II. The generation of serum factor(s) able to transfer alloantigen-specific tolerance for delayed-type hypersensitivity by portal venous inoculation with allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(8):2763-8.
1985: Hamaoka T; Takai Y; Kosugi A; Mizushima Y; Shima J; Kusama T; Fujiwara H
The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives. I. Synthesis of a novel haptenic MDP derivative cross-reactive with Bacillus Calmette Guerin and its application to enhanced induction of tumor immunity.
Cancer immunology, immunotherapy : CII 1985;20(3):183-8.

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