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Keigi Fujiwara

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TOP 3
Kyung-Sun Heo; Nhat-Tu Le; Edward T H Yeh; Eugene Chang; Hannah Cushman; Keigi Fujiwara; Jun-ichi Abe
De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.
Kyung-Sun Heo; Nhat-Tu Le; Craig N Morrell; Mark A Sullivan; Yuichiro Takei; Chang-Hoon Woo; Eugene Chang; Keigi Fujiwara; Jun-ichi Abe
Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Nhat-Tu Le; Hakjoo Lee; Faqian Li; Carolyn McClain; Craig N Morrell; Iana M Serafimova; Mark A Sullivan; Yuichiro Takei; Jack Taunton; Xin Wang; Chang-Hoon Woo; Haodong Xu; Eugene Chang; Michael S Cohen; Keigi Fujiwara; Kyung-Sun Heo; Cheryl Hurley; Jun-Ichi Abe
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.

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All Publications

2013: Kyung-Sun Heo; Nhat-Tu Le; Edward T H Yeh; Eugene Chang; Hannah Cushman; Keigi Fujiwara; Jun-ichi Abe
De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.
Circulation research 2013;112(6):911-23.
2013: Kyung-Sun Heo; Nhat-Tu Le; Craig N Morrell; Mark A Sullivan; Yuichiro Takei; Chang-Hoon Woo; Eugene Chang; Keigi Fujiwara; Jun-ichi Abe
Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(2):321-9.
2013: Nhat-Tu Le; Hakjoo Lee; Faqian Li; Carolyn McClain; Craig N Morrell; Iana M Serafimova; Mark A Sullivan; Yuichiro Takei; Jack Taunton; Xin Wang; Chang-Hoon Woo; Haodong Xu; Eugene Chang; Michael S Cohen; Keigi Fujiwara; Kyung-Sun Heo; Cheryl Hurley; Jun-Ichi Abe
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Circulation 2013;127(4):486-99.
2012: Geun-Young Kim; Patrizia Nigro; Jun-ichi Abe; Keigi Fujiwara; Bradford C Berk
p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(12):2974-80.
2012: Kyung-Sun Heo; Keigi Fujiwara; Jun-ichi Abe
Glucagon-like peptide-1 and its cardiovascular effects.
Current atherosclerosis reports 2012;14(5):422-8.
2012: Xiao-Qun Wang; Cameron World; Chen Yan; Keigi Fujiwara; Patrizia Nigro; Bradford C Berk
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.
Circulation research 2012;110(4):560-8.
2012: Nhat-Tu Le; Hakjoo Lee; Yan Lu; Carolyn McClain; Carlos A Molina; Craig N Morrell; Masayoshi Oikawa; Cam Patterson; Tetsuro Shishido; Yuichiro Takei; Jack Taunton; Cathy Tournier; Xin Wang; Chang-Hoon Woo; Chen Yan; Jay Yang; Eugene Chang; Keigi Fujiwara; Kyung-Sun Heo; Jun-ichi Abe
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Circulation research 2012;110(4):536-50.
2012: Nhat-Tu Le; Charles E Sparks; James P Corsetti; Janet L Dehoff-Sparks; Keigi Fujiwara; Jun-Ichi Abe
Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation.
International journal of inflammation 2012;2012():678190.
2011: Clint L Miller; Masayoshi Oikawa; Tamlyn Thomas; Yujun Cai; Wolfgang R Dostmann; Keigi Fujiwara; Manuela Zaccolo; Chen Yan
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
Basic research in cardiology 2011;106(6):1023-39.
2011: Kyung-Sun Heo; Hakjoo Lee; Patrizia Nigro; Tamlyn Thomas; Nhat-Tu Le; Eugene Chang; Carolyn McClain; Cynthia A Reinhart-King; Michael R King; Bradford C Berk; Keigi Fujiwara; Chang-Hoon Woo; Jun-ichi Abe
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
The Journal of cell biology 2011;193(5):867-84.
2011: Eugene Chang; Kyung-Sun Heo; Chang-Hoon Woo; Hakjoo Lee; Nhat-Tu Le; Tamlyn N Thomas; Keigi Fujiwara; Jun-ichi Abe
MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation.
Blood 2011;117(8):2527-37.
2011: Kyung-Sun Heo; Keigi Fujiwara; Jun-ichi Abe
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(12):2722-30.
2010: Patrizia Nigro; Jun-ichi Abe; Chang-Hoon Woo; Kimio Satoh; Carolyn McClain; Michael R O'Dell; Hakjoo Lee; Jae Hyang Lim; Jian-Dong Li; Kyung-Sun Heo; Keigi Fujiwara; Bradford C Berk
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
Blood 2010;116(11):1971-9.
2008: Yi-Jen Chiu; Elena McBeath; Keigi Fujiwara
Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation.
The Journal of cell biology 2008;182(4):753-63.
2008: Cynthia A Reinhart-King; Keigi Fujiwara; Bradford C Berk
Physiologic stress-mediated signaling in the endothelium.
Methods in enzymology 2008;443():25-44.
2002: Masaki Osawa; Michitaka Masuda; Ken-ichi Kusano; Keigi Fujiwara
Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?
The Journal of cell biology 2002;158(4):773-85.
2001: K Katoh; Y Kano; M Amano; K Kaibuchi; Keigi Fujiwara
Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts.
American journal of physiology. Cell physiology 2001;280(6):C1669-79.
2001: K Katoh; Y Kano; M Amano; Hirofumi Onishi; K Kaibuchi; Keigi Fujiwara
Rho-kinase--mediated contraction of isolated stress fibers.
The Journal of cell biology 2001;153(3):569-84.
2001: K Konishi; T Katoh; M Yazawa; K Kato; Keigi Fujiwara; Hirofumi Onishi
Two new modes of smooth muscle myosin regulation by the interaction between the two regulatory light chains, and by the S2 domain.
Journal of biochemistry 2001;129(3):365-72.
2001: S Kojima; K Konishi; K Katoh; Keigi Fujiwara; HM Martinez; Manuel F Morales; Hirofumi Onishi
Functional roles of ionic and hydrophobic surface loops in smooth muscle myosin: their interactions with actin.
Biochemistry 2001;40(3):657-64.
2000: Hirofumi Onishi; K Konishi; Keigi Fujiwara; K Hayakawa; M Tanokura; HM Martinez; Manuel F Morales
On the tryptophan residue of smooth muscle myosin that responds to binding of nucleotide.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11203-8.
2000: Y Kano; K Katoh; Keigi Fujiwara
Lateral zone of cell-cell adhesion as the major fluid shear stress-related signal transduction site.
Circulation research 2000;86(4):425-33.
2000: K Katoh; Y Kano; Keigi Fujiwara
Isolation and in vitro contraction of stress fibers.
Methods in enzymology 2000;325():369-80.
1999: S Kojima; Keigi Fujiwara; Hirofumi Onishi
SH1 (cysteine 717) of smooth muscle myosin: its role in motor function.
Biochemistry 1999;38(36):11670-6.
1998: K Katoh; Y Kano; Michitaka Masuda; Hirofumi Onishi; Keigi Fujiwara
Isolation and contraction of the stress fiber.
Molecular biology of the cell 1998;9(7):1919-38.
1998: Hirofumi Onishi; S Kojima; K Katoh; Keigi Fujiwara; HM Martinez; Manuel F Morales
Functional transitions in myosin: formation of a critical salt-bridge and transmission of effect to the sensitive tryptophan.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6653-8.
1998: Keigi Fujiwara; Michitaka Masuda; Masaki Osawa; K Katoh; Y Kano; N Harada; R B Lopes
Response of vascular endothelial cells to fluid flow.
The Biological bulletin 1998;194(3):384-5; discussion 385-6.
1998: Hirofumi Onishi; Manuel F Morales; S Kojima; K Katoh; Keigi Fujiwara
Smooth muscle myosin. Amino acid residues responsible for the hydrolysis of ATP.
Advances in experimental medicine and biology 1998;453():99-103; discussion 103-4.
1997: Michitaka Masuda; Masaki Osawa; H Shigematsu; N Harada; Keigi Fujiwara
Platelet endothelial cell adhesion molecule-1 is a major SH-PTP2 binding protein in vascular endothelial cells.
FEBS letters 1997;408(3):331-6.
1997: Hirofumi Onishi; Manuel F Morales; S Kojima; K Katoh; Keigi Fujiwara
Functional transitions in myosin: role of highly conserved Gly and Glu residues in the active site.
Biochemistry 1997;36(13):3767-72.
1997: Masaki Osawa; Michitaka Masuda; N Harada; R B Lopes; Keigi Fujiwara
Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells.
European journal of cell biology 1997;72(3):229-37.
1996: Y Kano; K Katoh; Michitaka Masuda; Keigi Fujiwara
Macromolecular composition of stress fiber-plasma membrane attachment sites in endothelial cells in situ.
Circulation research 1996;79(5):1000-6.
1996: K Katoh; Y Kano; Michitaka Masuda; Keigi Fujiwara
Mutually exclusive distribution of the focal adhesion associated proteins and the erythrocyte membrane skeleton proteins in the human fibroblast plasma membrane undercoat.
Cell structure and function 1996;21(1):27-39.
1995: Hirofumi Onishi; Manuel F Morales; K Katoh; Keigi Fujiwara
The putative actin-binding role of hydrophobic residues Trp546 and Phe547 in chicken gizzard heavy meromyosin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):11965-9.
1995: Hirofumi Onishi; K Maéda; Yuichiro Maéda; A Inoue; Keigi Fujiwara
Functional chicken gizzard heavy meromyosin expression in and purification from baculovirus-infected insect cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):704-8.
1995: K Katoh; Michitaka Masuda; Y Kano; Y Jinguji; Keigi Fujiwara
Focal adhesion proteins associated with apical stress fibers of human fibroblasts.
Cell motility and the cytoskeleton 1995;31(3):177-95.
1993: H Sunada; Michitaka Masuda; Keigi Fujiwara
Preservation of differentiated phenotypes in cultured aortic endothelial cells by malotilate and phosphoascorbic acid.
European journal of cell biology 1993;60(1):48-56.
1992: Hirofumi Onishi; T Maita; G Matsuda; Keigi Fujiwara
Interaction between the heavy and the regulatory light chains in smooth muscle myosin subfragment 1.
Biochemistry 1992;31(4):1201-10.
1992: Hirofumi Onishi; T Maita; G Matsuda; Keigi Fujiwara
Interaction between the heavy chain (HC) and the regulatory light chain (RLC) in smooth muscle myosin subfragment-1 (S-1).
Japanese journal of pharmacology 1992;58 Suppl 2():265P.
1991: Keigi Fujiwara; Y Jinguji; Michitaka Masuda
[Cell adhesion and the cytoskeleton].
Human cell 1991;4(2):109-15.
1990: Hirofumi Onishi; T Maita; G Matsuda; Keigi Fujiwara
Lys-65 and Glu-168 are the residues for carbodiimide-catalyzed cross-linking between the two heads of rigor smooth muscle heavy meromyosin.
The Journal of biological chemistry 1990;265(31):19362-8.
1990: E McBeath; Keigi Fujiwara
Microtubule detachment from the microtubule-organizing center as a key event in the complete turnover of microtubules in cells.
European journal of cell biology 1990;52(1):1-16.
1990: Hirofumi Onishi; Keigi Fujiwara
The rigor configuration of smooth muscle heavy meromyosin trapped by a zero-length cross-linker.
Biochemistry 1990;29(12):3013-23.
1989: E McBeath; Keigi Fujiwara
Coalignment of microtubules, cytokeratin intermediate filaments, and collagen fibrils in a collagen-secreting cell system.
European journal of cell biology 1989;50(2):510-21.
1989: Hirofumi Onishi; T Maita; G Matsuda; Keigi Fujiwara
Carbodiimide-catalyzed cross-linking sites in the heads of gizzard heavy meromyosin attached to F-actin.
Biochemistry 1989;28(4):1905-12.
1989: Hirofumi Onishi; T Maita; G Matsuda; Keigi Fujiwara
Evidence for the association between two myosin heads in rigor acto-smooth muscle heavy meromyosin.
Biochemistry 1989;28(4):1898-904.