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Akiyoshi Fukamizu

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Katsumasa Nagano; Madoka Unno; Junji Ishida; Tanomu Matsukura; Akiyoshi Fukamizu
Apelin elevates blood pressure in ICR mice with L‑NAME‑induced endothelial dysfunction.
Kazuya Murata; Chiaki Saito; Fumihiro Sugiyama; Ken-Ichi Yagami; Juri Hamada; Junji Ishida; Akiyoshi Fukamizu
Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice.
Eiichi Okamura; Ryuuta Sakaguchi; Takuya Takahashi; Akiyoshi Fukamizu; Hitomi Matsuzaki; Keiji Tanimoto
The H19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice.

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2013: Katsumasa Nagano; Madoka Unno; Junji Ishida; Tanomu Matsukura; Akiyoshi Fukamizu
Apelin elevates blood pressure in ICR mice with L‑NAME‑induced endothelial dysfunction.
Molecular medicine reports 2013;7(5):1371-5.
2013: Kazuya Murata; Chiaki Saito; Fumihiro Sugiyama; Ken-Ichi Yagami; Juri Hamada; Junji Ishida; Akiyoshi Fukamizu
Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice.
Endocrinology 2013;154(2):597-602.
2013: Eiichi Okamura; Ryuuta Sakaguchi; Takuya Takahashi; Akiyoshi Fukamizu; Hitomi Matsuzaki; Keiji Tanimoto
The H19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice.
Molecular and cellular biology 2013;33(4):858-71.
2013: Hideki Amano; Koji Eshima; Akiyoshi Fukamizu; Tomoya Fukui; Yoshiya Ito; Shintaro Kato; Hidero Kitasato; Yoshio Matsui; Masaki Nakamura; Kazuhito Oba; Fumihiro Ogawa; Tatsunori Suzuki; Masataka Majima
Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.
The American journal of pathology 2013;182(2):553-64.
2013: Hiroko Tamiya; Satoshi Watanabe; Hiroaki Daitoku; Keiko Hirota; Kei Iizuka; Naoaki Ishii; Yuta Kaneko; Genki Sakuta; Yuta Takahashi; Akiyoshi Fukamizu
Conserved SAMS function in regulating egg-laying in C. elegans.
Journal of receptor and signal transduction research 2013;33(1):56-62.
2012: Yusuke Nagashima; Koichiro Kako; Jun-Dal Kim; Akiyoshi Fukamizu
Enhanced histamine production through the induction of histidine decarboxylase expression by phorbol ester in Jurkat cells.
Molecular medicine reports 2012;6(5):944-8.
2012: Takuya Takahashi; Shin-Ichi Tomizawa; Akiyoshi Fukamizu; Tomoko Ichiyanagi; Hitomi Matsuzaki; Eiichi Okamura; Hiroyuki Sasaki; Keiji Tanimoto
Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice.
Gene 2012;508(1):26-34.
2012: Keiji Tanimoto; Akiyoshi Fukamizu
[Transcriptional regulation of RAAS genes--in vivo analysis by artificial chromosome transgenic mouse].
Nihon rinsho. Japanese journal of clinical medicine 2012;70(9):1466-70.
2012: Tatsuo Hashimoto; Hiroaki Ishiguro; Keiji Kuba; Simone Lipinski; Magdalena Paolino; Simone M R Camargo; Hans Clevers; Akiyoshi Fukamizu; Reiko Hanada; Toshikatsu Hanada; Thomas Perlot; Ateequr Rehman; Andreas Richter; Philip Rosenstiel; Stefan Schreiber; Verena Sigl; Dustin Singer; Jean Trichereau; Francois Verrey; Birgit Wild; Josef M Penninger
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Nature 2012;487(7408):477-81.
2012: Kana Namiki; Akira Sakairi; Nobuhiko Shibakawa; Manabu Shigetomi; Motohisa Shimizu; Tatsuhiko Sudo; Kensuke Tanaka; Naoki Tokuhara; Yasunori Tokunaga; Yukinori Wada; Kento Yoshioka; Akiyoshi Fukamizu; Masahiko Hagihara; Junji Ishida; Jundal Kim; Sadao Kimura; Hirofumi Matsunaga; Kazuya Murata; Yoshitoshi Kasuya
Mechanism for p38α-mediated experimental autoimmune encephalomyelitis.
The Journal of biological chemistry 2012;287(29):24228-38.
2012: Tomohiro Ishimaru; Satoshi Kunita; Tanomu Matsukura; Ayumi Nakamura; Shoko Nakamura; Fumihiro Sugiyama; Ken-Ichi Yagami; Misuzu Hashimoto; Junji Ishida; Akiyoshi Fukamizu
Short-term suppression of the renin-angiotensin system in mice associated with hypertension during pregnancy.
Molecular medicine reports 2012;6(1):28-32.
2012: Yoshinori Hokari; Yoshiaki Kiso; Yuko Matsuo; Eisuke Munekata; Hiroko Nakano; Tetsuo Seki; Akiyoshi Fukamizu; Hidehito Mukai
Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome C.
Protein and peptide letters 2012;19(6):680-7.
2012: Lale Ozcan; Utpal Pajvani; Sung Kyu Robin Park; Harold A Singer; Domenico Accili; Johannes Backs; Bi-Xing Chen; Akiyoshi Fukamizu; Gang Li; Andrew R Marks; Catherine C L Wong; Anetta Wronska; Tao Xu; John R Yates; Ira Tabas
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.
Cell metabolism 2012;15(5):739-51.
2012: Shigetomo Fukuhara; Masanori Hirashima; Asuka Inoue; Junji Ishida; Masaru Ishii; Shunsuke Kawamura; Hiroshi Kiyonari; Takaya Abe; Junken Aoki; Yuji Arai; Akiyoshi Fukamizu; Kazumasa Moriwaki; Yasuko Orba; Hirofumi Sawa; Szandor Simmons; Yuji Sunden; Takeshi Tokudome; Akiyoshi Uemura; Naoki Mochizuki
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
The Journal of clinical investigation 2012;122(4):1416-26.
2012: Jun-ichi Sakamaki; Katsuya Ueno; Hiroaki Daitoku; Ayano Hagiwara; Yuta Kaneko; Akiyoshi Fukamizu
GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1.
Journal of receptor and signal transduction research 2012;32(2):96-101.
2012: Susumu Sakimoto; Akiyoshi Fukamizu; Nobuhito Goda; Motohiro Kamei; Hiroyasu Kidoya; Hisamichi Naito; Kohji Nishida; Hirokazu Sakaguchi; Nobuyuki Takakura
A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice.
Development (Cambridge, England) 2012;139(7):1327-35.
2011: Keiko Kaneko; Junji Ishida; Masako Ito; Akiyoshi Fukamizu; Ryoji Fukuhara; Toshio Fumoto; Kyoji Ikeda
Physiological function of the angiotensin AT1a receptor in bone remodeling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(12):2959-66.
2011: Hiroaki Daitoku; Jun-Ichi Sakamaki; Akiyoshi Fukamizu
Regulation of FoxO transcription factors by acetylation and protein-protein interactions.
Biochimica et biophysica acta 2011;1813(11):1954-60.
2011: Junji Ishida; Satoshi Kunita; Toshiki Matsuoka; Tomoko Saito-Fujita; Fumihiro Sugiyama; Ken-ichi Yagami; Saki Inaba; Akiyoshi Fukamizu
Pregnancy-associated homeostasis and dysregulation: lessons from genetically modified animal models.
Journal of biochemistry 2011;150(1):5-14.
2011: Takuma Shirakawa; Koichiro Kako; Takashi Shimada; Yusuke Nagashima; Ayumi Nakamura; Junji Ishida; Akiyoshi Fukamizu
Production of free methylarginines via the proteasome and autophagy pathways in cultured cells.
Molecular medicine reports 2011;4(4):615-20.
2011: Akira Kobayashi; Tomohiro Miyasaka; Tatsuya Mizoroki; Tomoko Morita; Noriko Noguchi; Makiko Ohtsuji; Yoshiro Saito; Akihiko Takashima; Takako Tsukide; Akiyoshi Fukamizu; Yosuke Hirotsu; Yasuo Ihara; Fumiki Katsuoka; Masayuki Yamamoto
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(6):692-703.
2011: Yuta Takahashi; Hiroaki Daitoku; Keiko Hirota; Hiroko Tamiya; Atsuko Yokoyama; Koichiro Kako; Yusuke Nagashima; Ayumi Nakamura; Takashi Shimada; Satoshi Watanabe; Kazuyuki Yamagata; Kayo Yasuda; Naoaki Ishii; Akiyoshi Fukamizu
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.
Cell metabolism 2011;13(5):505-16.
2011: Jun-ichi Sakamaki; Hiroaki Daitoku; Katsuya Ueno; Ayano Hagiwara; Kazuyuki Yamagata; Akiyoshi Fukamizu
Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(15):6085-90.
2011: Yuta Takahashi; Hiroaki Daitoku; Atsuko Yokoyama; Kimihiro Nakayama; Jun-Dal Kim; Akiyoshi Fukamizu
The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity.
Journal of receptor and signal transduction research 2011;31(2):168-72.
2011: Tetsuo Seki; Akiyoshi Fukamizu; Yoshiaki Kiso; Hidehito Mukai
Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1.
Biochemical and biophysical research communications 2011;404(1):482-7.
2011: Yuka Nakajima; Kensuke Akaogi; Takashi Suzuki; Asami Osakabe; Chie Yamaguchi; Nanae Sunahara; Junji Ishida; Koichiro Kako; Sonoko Ogawa; Tetsuya Fujimura; Yukio Homma; Akiyoshi Fukamizu; Akiko Murayama; Keiji Kimura; Satoshi Inoue; Junn Yanagisawa
Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.
Science signaling 2011;4(168):ra22.
2010: Keiko Hirota; Akiyoshi Fukamizu
Transcriptional regulation of energy metabolism in the liver.
Journal of receptor and signal transduction research 2010;30(6):403-9.
2010: Takayuki Oishi; Shoichi Date; Yoko Shimamoto; Tomoko Saito; Keiko Hirota; Takeshi Sugaya; Yasuhiro Kon; Akiyoshi Fukamizu; Keiji Tanimoto
A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities.
Journal of receptor and signal transduction research 2010;30(6):484-92.
2010: Raquel del Toro; Claudia Prahst; Thomas Mathivet; Geraldine Siegfried; Joshua S Kaminker; Bruno Larrivee; Christiane Breant; Antonio Duarte; Nobuyuki Takakura; Akiyoshi Fukamizu; Josef Penninger; Anne Eichmann
Identification and functional analysis of endothelial tip cell-enriched genes.
Blood 2010;116(19):4025-33.
2010: Motoshi Shimotsuma; Eiichi Okamura; Hitomi Matsuzaki; Akiyoshi Fukamizu; Keiji Tanimoto
DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.
The Journal of biological chemistry 2010;285(19):14495-503.
2010: Hitomi Matsuzaki; Eiichi Okamura; Akiyoshi Fukamizu; Keiji Tanimoto
CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR.
Human molecular genetics 2010;19(7):1190-8.
2010: Michiko Sugawara; Kiyoshi Okamoto; Tadashi Kadowaki; Kazutomi Kusano; Akiyoshi Fukamizu; Tsutomu Yoshimura
Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(3):526-33.
2010: Kenji Yoshimochi; Hiroaki Daitoku; Akiyoshi Fukamizu
PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner.
Journal of receptor and signal transduction research 2010;30(1):43-9.
2010: Wa Du; Noriko Takuwa; Kazuaki Yoshioka; Yasuo Okamoto; Koichi Gonda; Kazushi Sugihara; Akiyoshi Fukamizu; Masahide Asano; Yoh Takuwa
S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.
Cancer research 2010;70(2):772-81.
2010: Akiyoshi Fukamizu
[New codified regulation of arginine methylation and Akt-induced phosphorylation].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2010;55(1):69-73.
2010: Kaeko Kamide; Hiroshi Nakakubo; Shusei Uno; Akiyoshi Fukamizu
Isolation of novel cell-penetrating peptides from a random peptide library using in vitro virus and their modifications.
International journal of molecular medicine 2010;25(1):41-51.
2009: Eiichi Okamura; Hitomi Matsuzaki; Andrew D Campbell; James Douglas Engel; Akiyoshi Fukamizu; Keiji Tanimoto
All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4335-43.
2009: Natsumi Araya; Hitoshi Arimura; Ko-ichi Kawahara; Naoko Yagishita; Junji Ishida; Ryoji Fujii; Satoko Aratani; Hidetoshi Fujita; Tomoo Sato; Yoshihisa Yamano; Itsuro Higuchi; Mitsuhiro Osame; Kusuki Nishioka; Akiyoshi Fukamizu; Kimiyoshi Arimura; Ikuro Maruyama; Toshihiro Nakajima
Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.
International journal of molecular medicine 2009;24(5):605-11.
2009: Michiko Sugawara; Kiyoshi Okamoto; Tadashi Kadowaki; Kazutomi Kusano; Akiyoshi Fukamizu; Tsutomu Yoshimura
Inoculation of human tumor cells alters the basal expression but not the inducibility of cytochrome P450 enzymes in tumor-bearing mouse liver.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2244-54.
2009: Maya Kurosaka; Tatsunori Suzuki; Kanako Hosono; Yuji Kamata; Akiyoshi Fukamizu; Hidero Kitasato; Yoshikuni Fujita; Masataka Majima
Reduced angiogenesis and delay in wound healing in angiotensin II type 1a receptor-deficient mice.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2009;63(9):627-34.
2009: Hitomi Matsuzaki; Eiichi Okamura; Motoshi Shimotsuma; Akiyoshi Fukamizu; Keiji Tanimoto
A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells.
Molecular and cellular biology 2009;29(17):4595-603.
2009: Kazuyuki Yamagata; Hiroaki Daitoku; Akiyoshi Fukamizu
[Regulation of cellular functions by arginine methylation].
Seikagaku. The Journal of Japanese Biochemical Society 2009;81(8):688-99.
2009: Shingo Satofuka; Atsuhiro Ichihara; Norihiro Nagai; Kousuke Noda; Yoko Ozawa; Akiyoshi Fukamizu; Kazuo Tsubota; Hiroshi Itoh; Yuichi Oike; Susumu Ishida
(Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation.
Diabetes 2009;58(7):1625-33.
2009: Jun-ichi Sakamaki; Hiroaki Daitoku; Kenji Yoshimochi; Masanao Miwa; Akiyoshi Fukamizu
Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.
Biochemical and biophysical research communications 2009;382(3):497-502.
2009: Yasuhiro Hara; Yoshiaki Onishi; Katsutaka Oishi; Koyomi Miyazaki; Akiyoshi Fukamizu; Norio Ishida
Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.
Nucleic acids research 2009;37(4):1115-26.
2009: Keisuke Sako; Shigetomo Fukuhara; Takashi Minami; Takao Hamakubo; Haihua Song; Tatsuhiko Kodama; Akiyoshi Fukamizu; J Silvio Gutkind; Gou Young Koh; Naoki Mochizuki
Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.
The Journal of biological chemistry 2009;284(9):5592-601.
2009: Yutaro Asaba; Masako Ito; Toshio Fumoto; Ken Watanabe; Ryoji Fukuhara; Sunao Takeshita; Yuji Nimura; Junji Ishida; Akiyoshi Fukamizu; Kyoji Ikeda
Activation of renin-angiotensin system induces osteoporosis independently of hypertension.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009;24(2):241-50.
2009: Yu Ito; Hiroaki Daitoku; Akiyoshi Fukamizu
Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes.
Biochemical and biophysical research communications 2009;378(2):290-5.
2008: Akira Sakairi; Junji Ishida; Kaori Honjo; Saki Inaba; Shoko Nakamura; Fumihiro Sugiyama; Ken-Ichi Yagami; Akiyoshi Fukamizu
Angiotensin type 1 receptor blockade prevents cardiac remodeling in mice with pregnancy-associated hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(12):2165-75.
2008: Shingo Satofuka; Atsuhiro Ichihara; Norihiro Nagai; Kousuke Noda; Yoko Ozawa; Akiyoshi Fukamizu; Kazuo Tsubota; Hiroshi Itoh; Yuichi Oike; Susumu Ishida
(Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system.
The American journal of pathology 2008;173(6):1911-8.
2008: Keiko Hirota; Jun-ichi Sakamaki; Junji Ishida; Yoko Shimamoto; Shigeki Nishihara; Norio Kodama; Kazuhide Ohta; Masayuki Yamamoto; Keiji Tanimoto; Akiyoshi Fukamizu
A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.
The Journal of biological chemistry 2008;283(47):32432-41.
2008: Kazuyuki Yamagata; Hiroaki Daitoku; Yuta Takahashi; Kana Namiki; Hisatake Koji; Koichiro Kako; Hidehito Mukai; Yoshitoshi Kasuya; Akiyoshi Fukamizu
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
Molecular cell 2008;32(2):221-31.
2008: Juri Hamada; Junko Kimura; Junji Ishida; Takeo Kohda; Setsuo Morishita; Shigeyasu Ichihara; Akiyoshi Fukamizu
Evaluation of novel cyclic analogues of apelin.
International journal of molecular medicine 2008;22(4):547-52.
2008: Jun-Dal Kim; Koichiro Kako; Misako Kakiuchi; Gwi-Gun Park; Akiyoshi Fukamizu
EWS is a substrate of type I protein arginine methyltransferase, PRMT8.
International journal of molecular medicine 2008;22(3):309-15.
2008: Osamu Ohno; Mao Ye; Tomoyuki Koyama; Kazunaga Yazawa; Emi Mura; Hiroshi Matsumoto; Takao Ichino; Kaoru Yamada; Kazuhiko Nakamura; Tomohiro Ohno; Kohji Yamaguchi; Junji Ishida; Akiyoshi Fukamizu; Daisuke Uemura
Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension.
Bioorganic & medicinal chemistry 2008;16(16):7843-52.
2008: Katsutoshi Yayama; Ryoko Miyagi; Kaori Sugiyama; takeshi sugaya; Akiyoshi Fukamizu; Hiroshi Okamoto
Angiotensin II regulates liver regeneration via type 1 receptor following partial hepatectomy in mice.
Biological & pharmaceutical bulletin 2008;31(7):1356-61.
2008: Sachie Asada; Akemi Ikeda; Rina Nagao; Hiroshi Hama; Tatsuhiko Sudo; Akiyoshi Fukamizu; Yoshitoshi Kasuya; Tsutomu Kishi
Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.
International journal of molecular medicine 2008;22(1):95-104.
2008: Hideki Kato; Junji Ishida; Katsumasa Nagano; Kaori Honjo; takeshi sugaya; Norifumi Takeda; Fumihiro Sugiyama; Ken-ichi Yagami; Toshiro Fujita; Masaomi Nangaku; Akiyoshi Fukamizu
Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells.
Laboratory investigation; a journal of technical methods and pathology 2008;88(7):731-9.
2008: Akiko Murayama; Kazuji Ohmori; Akiko Fujimura; Hiroshi Minami; Kayoko Yasuzawa-Tanaka; Takao Kuroda; Shohei Oie; Hiroaki Daitoku; Mitsuru Okuwaki; Kyosuke Nagata; Akiyoshi Fukamizu; Keiji Kimura; Toshiyuki Shimizu; Junn Yanagisawa
Epigenetic control of rDNA loci in response to intracellular energy status.
Cell 2008;133(4):627-39.
2008: Mitsuko Furuya; Junji Ishida; Saki Inaba; Yoshitoshi Kasuya; Sadao Kimura; Ryoichi Nemori; Akiyoshi Fukamizu
Impaired placental neovascularization in mice with pregnancy-associated hypertension.
Laboratory investigation; a journal of technical methods and pathology 2008;88(4):416-29.
2008: Hong Lu; Debra L Rateri; David L Feldman; Richard J Charnigo Jr; Akiyoshi Fukamizu; Junji Ishida; Elizabeth G Oesterling; Lisa A Cassis; Alan Daugherty
Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice.
The Journal of clinical investigation 2008;118(3):984-93.
2008: Keiji Tanimoto; Akiko Sugiura; Sumiyo Kanafusa; Tomoko Saito; Naoto Masui; Kazuyuki Yanai; Akiyoshi Fukamizu
A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation.
The Journal of clinical investigation 2008;118(3):1006-16.
2008: Mitsuko Furuya; Junji Ishida; Ichiro Aoki; Akiyoshi Fukamizu
Pathophysiology of placentation abnormalities in pregnancy-induced hypertension.
Vascular health and risk management 2008;4(6):1301-13.
2007: Tatsuo Hashimoto; Minoru Kihara; Nozomi Imai; Shin-Ichiro Yoshida; Hiroaki Shimoyamada; Hiroaki Yasuzaki; Junji Ishida; Yoshiyuki Toya; Yoshihiro Kiuchi; Nobuhito Hirawa; Kouichi Tamura; Takuya Yazawa; Hitoshi Kitamura; Akiyoshi Fukamizu; Satoshi Umemura
Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis.
The American journal of pathology 2007;171(5):1705-12.
2007: Mariko Umemura; Morihisa Fujita; Takehiko Yoko-o; Akiyoshi Fukamizu; Yoshifumi Jigami
Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.
Molecular biology of the cell 2007;18(11):4304-16.
2007: Keisuke Sekine; Yen-Rong Chen; Nobuhiko Kojima; Kazuhiro Ogata; Akiyoshi Fukamizu; Atsushi Miyajima
Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development.
The EMBO journal 2007;26(15):3607-15.
2007: Michio Nakanishi; Masaki Harada; Ichiro Kishimoto; Koichiro Kuwahara; Rika Kawakami; Yasuaki Nakagawa; Shinji Yasuno; Satoru Usami; Hideyuki Kinoshita; Yuichiro Adachi; Akiyoshi Fukamizu; Yoshihiko Saito; Kazuwa Nakao
Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(8):1310-6.
2007: Motoshi Shimotsuma; Hitomi Matsuzaki; Osamu Tanabe; Andrew D Campbell; James Douglas Engel; Akiyoshi Fukamizu; Keiji Tanimoto
Linear distance from the locus control region determines epsilon-globin transcriptional activity.
Molecular and cellular biology 2007;27(16):5664-72.
2007: Jianyong Zhang; Tomonori Hosoya; Atsushi Maruyama; Keizo Nishikawa; Jonathan M Maher; Tsutomu Ohta; Hozumi Motohashi; Akiyoshi Fukamizu; Shigeki Shibahara; Ken Itoh; Masayuki Yamamoto
Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.
The Biochemical journal 2007;404(3):459-66.
2007: Hiroaki Daitoku; Akiyoshi Fukamizu
FOXO transcription factors in the regulatory networks of longevity.
Journal of biochemistry 2007;141(6):769-74.
2007: Kazuyuki Yamagata; Kenji Yoshimochi; Hiroaki Daitoku; Keiko Hirota; Akiyoshi Fukamizu
Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner.
International journal of molecular medicine 2007;19(5):751-6.
2007: WuQiang Fan; Toshihiko Yanase; Hidetaka Morinaga; Taijiro Okabe; Masatoshi Nomura; Hiroaki Daitoku; Akiyoshi Fukamizu; Shigeaki Kato; Ryoichi Takayanagi; Hajime Nawata
Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor.
The Journal of biological chemistry 2007;282(10):7329-38.
2007: Sachie Asada; Hiroaki Daitoku; Hitomi Matsuzaki; Tomoko Saito; Tatsuhiko Sudo; Hidehito Mukai; Shintaro Iwashita; Koichiro Kako; Tsutomu Kishi; Yoshitoshi Kasuya; Akiyoshi Fukamizu
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.
Cellular signalling 2007;19(3):519-27.
2006: Jun Nakae; Yongheng Cao; Hiroaki Daitoku; Akiyoshi Fukamizu; Wataru Ogawa; Yoshihiko Yano; Yoshitake Hayashi
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.
The Journal of clinical investigation 2006;116(9):2473-83.
2006: Hisanori Aoyama; Hiroaki Daitoku; Akiyoshi Fukamizu
Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice.
International journal of molecular medicine 2006;18(3):433-9.
2006: Valentina Marchetti; Rossella Menghini; Stefano Rizza; Alessia Vivanti; Tiziana Feccia; Davide Lauro; Akiyoshi Fukamizu; Renato Lauro; Massimo Federici
Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling.
Diabetes 2006;55(8):2231-7.
2006: Akiyoshi Fukamizu
[Genetic dissection of the renin-angiotensin system].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():273-7.
2006: Tatsuo Hashimoto; Minoru Kihara; Junji Ishida; Nozomi Imai; Shin-ichiro Yoshida; Yoshiyuki Toya; Akiyoshi Fukamizu; Hitoshi Kitamura; Satoshi Umemura
Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(6):1267-72.
2006: Ryuji Utsunomiya; Kyoko Suto; Dhakshnamoorthy Balasundaresan; Akiyoshi Fukamizu; PARMOD KUMAR; Hiroshi Mizuno
Structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G.U base pairs.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 3):331-8.
2006: Mitsutoki Hatta; Yoshitaka Yoshimura; Yoshiaki Deyama; Akiyoshi Fukamizu; Kuniaki Suzuki
Molecular characterization of the zinc finger transcription factor, Osterix.
International journal of molecular medicine 2006;17(3):425-30.
2006: Satoko Aratani; Takayuki Oishi; Hidetoshi Fujita; Minako Nakazawa; Ryouji Fujii; Naoko Imamoto; Yoshihiro Yoneda; Akiyoshi Fukamizu; Toshihiro Nakajima
The nuclear import of RNA helicase A is mediated by importin-alpha3.
Biochemical and biophysical research communications 2006;340(1):125-33.
2006: Tatsuo Hashimoto; Minoru Kihara; Keiko Sato; Kei Matsushita; Keiji Tanimoto; Yoshiyuki Toya; Akiyoshi Fukamizu; Satoshi Umemura
Expression of cyclooxygenase-2 in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice.
Nephron. Physiology 2006;102(1):p1-8.
2005: Mayuko Nakahara; Norihiko Furuya; Kentaro Takagaki; Takeshi Sugaya; Keiko Hirota; Akiyoshi Fukamizu; Tatsuo Kanda; Hiroshi Fujii; Ryuichiro Sato
Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.
The Journal of biological chemistry 2005;280(51):42283-9.
2005: Hideki Kato; Junji Ishida; Shigehiko Imagawa; Tomoko Saito; Norio Suzuki; Toshiki Matsuoka; takeshi sugaya; Keiji Tanimoto; Takashi Yokoo; Osamu Ohneda; Fumihiro Sugiyama; Ken-ichi Yagami; Toshiro Fujita; Masayuki Yamamoto; Masaomi Nangaku; Akiyoshi Fukamizu
Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2023-5.
2005: Yasumi Hashimoto; Junji Ishida; Rie Yamamoto; Kae Fujiwara; Sachie Asada; Yoshitoshi Kasuya; Naoki Mochizuki; Akiyoshi Fukamizu
G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility.
International journal of molecular medicine 2005;16(5):787-92.
2005: Nobuhiro Suzuki; Zui Fujimoto; Takashi Morita; Akiyoshi Fukamizu; Hiroshi Mizuno
pH-Dependent structural changes at Ca(2+)-binding sites of coagulation factor IX-binding protein.
Journal of molecular biology 2005;353(1):80-7.
2005: Hitomi Matsuzaki; Hiroaki Daitoku; Mitsutoki Hatta; Hisanori Aoyama; Kenji Yoshimochi; Akiyoshi Fukamizu
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(32):11278-83.
2005: Kaneyuki Tsuchimochi; Naoko Yagishita; Satoshi Yamasaki; Tetsuya Amano; Yukihiro Kato; Ko-ichi Kawahara; Satoko Aratani; Hidetoshi Fujita; Fengyun Ji; Akiko Sugiura; Toshihiko Izumi; Asako Sugamiya; Ikuro Maruyama; Akiyoshi Fukamizu; Setsuro Komiya; Kusuki Nishioka; Toshihiro Nakajima
Identification of a crucial site for synoviolin expression.
Molecular and cellular biology 2005;25(16):7344-56.
2005: Michio Nakanishi; Yoshihiko Saito; Ichiro Kishimoto; Masaki Harada; Koichiro Kuwahara; Nobuki Takahashi; Rika Kawakami; Yasuaki Nakagawa; Keiji Tanimoto; Shinji Yasuno; Satoru Usami; Yuhao Li; Yuichiro Adachi; Akiyoshi Fukamizu; David L Garbers; Kazuwa Nakao
Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice.
Hypertension 2005;46(2):441-7.
2005: Ryuji Kouyama; Takayoshi Suganami; Junko Nishida; Miyako Tanaka; Takuya Toyoda; Minako Kiso; Tsuyoshi Chiwata; Yoshihiro Miyamoto; Yasunao Yoshimasa; Akiyoshi Fukamizu; Masatsugu Horiuchi; Yukio Hirata; Yoshihiro Ogawa
Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor.
Endocrinology 2005;146(8):3481-9.
2005: Keiji Tanimoto; Motoshi Shimotsuma; Hitomi Matsuzaki; Akane Omori; Jörg Bungert; James Douglas Engel; Akiyoshi Fukamizu
Genomic imprinting recapitulated in the human beta-globin locus.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10250-5.
2005: Yumiko Imai; Keiji Kuba; Shuan Rao; Yi Huan; Feng Guo; Bin Guan; Peng Yang; Renu Sarao; Teiji Wada; Howard Leong-Poi; Michael A Crackower; Akiyoshi Fukamizu; Chi-Chung Hui; Lutz Hein; Stefan Uhlig; Arthur Slutsky; Chengyu Jiang; Josef M Penninger
Angiotensin-converting enzyme 2 protects from severe acute lung failure.
Nature 2005;436(7047):112-6.
2005: Minori Dateki; Takuro Horii; Yoshitoshi Kasuya; Reiko Mochizuki; Yasumitsu Nagao; Junji Ishida; Fumihiro Sugiyama; Keiji Tanimoto; Ken-ichi Yagami; Hiroshi Imai; Akiyoshi Fukamizu
Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure.
The Journal of biological chemistry 2005;280(21):20503-8.
2005: Hiroaki Daitoku; Akiyoshi Fukamizu
[FOXO: the regulator of metabolism, longevity, and aging].
Seikagaku. The Journal of Japanese Biochemical Society 2005;77(5):423-7.
2005: Akane Omori; Osamu Tanabe; James Douglas Engel; Akiyoshi Fukamizu; Keiji Tanimoto
Adult stage gamma-globin silencing is mediated by a promoter direct repeat element.
Molecular and cellular biology 2005;25(9):3443-51.
2005: Eriko Takimoto-Ohnishi; Tomoko Saito; Junji Ishida; Junji Ohnishi; Fumihiro Sugiyama; Ken-ichi Yagami; Akiyoshi Fukamizu
Differential roles of renin and angiotensinogen in the feto-maternal interface in the development of complications of pregnancy.
Molecular endocrinology (Baltimore, Md.) 2005;19(5):1361-72.
2005: Natsumi Araya; Hideaki Hiraga; Koichiro Kako; Yukitomo Arao; Shigeaki Kato; Akiyoshi Fukamizu
Transcriptional down-regulation through nuclear exclusion of EWS methylated by PRMT1.
Biochemical and biophysical research communications 2005;329(2):653-60.
2005: Taku Shimizu; Takayuki Oishi; Akane Omori; Akiko Sugiura; Keiko Hirota; Hisanori Aoyama; Tomoko Saito; takeshi sugaya; Yasuhiro Kon; James Douglas Engel; Akiyoshi Fukamizu; Keiji Tanimoto
Identification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination.
Molecular and cellular biology 2005;25(8):2938-45.
2005: Hidetoshi Fujita; Takayuki Ohshima; Takayuki Oishi; Satoko Aratani; Ryouji Fujii; Akiyoshi Fukamizu; Toshihiro Nakajima
Relevance of nuclear localization and functions of RNA helicase A.
International journal of molecular medicine 2005;15(4):555-60.
2005: Naoko Yagishita; Kinuko Ohneda; Tetsuya Amano; Satoshi Yamasaki; Akiko Sugiura; Kaneyuki Tsuchimochi; Hiroshi Shin; Ko-Ichi Kawahara; Osamu Ohneda; Tomohiko Ohta; Sakae Tanaka; Masayuki Yamamoto; Ikuro Maruyama; Kusuki Nishioka; Akiyoshi Fukamizu; Toshihiro Nakajima
Essential role of synoviolin in embryogenesis.
The Journal of biological chemistry 2005;280(9):7909-16.
2005: Akiyoshi Fukamizu
[Genetic dissection of the renin-angiotensin system].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 3():42-8.
2005: Akiyoshi Fukamizu
[A new paradigm for renin research].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 3():12-6.
2005: Keiko Hirota; Hisanori Aoyama; Akiyoshi Fukamizu
Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promoter.
International journal of molecular medicine 2005;15(3):487-90.
2005: Mamoru Fujita; Izumi Hayashi; Shohei Yamashina; Akiyoshi Fukamizu; Moritoshi Itoman; Masataka Majima
Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth.
Carcinogenesis 2005;26(2):271-9.
2005: Yuichi Kunori; Yumiko Muroga; Minako Iidaka; Hiroaki Mitsuhashi; TAKASHI KAMIMURA; Akiyoshi Fukamizu
Species differences in angiotensin II generation and degradation by mast cell chymases.
Journal of receptor and signal transduction research 2005;25(1):35-44.
2004: Koichiro Kako; Akio Takehara; Hidenori Arai; Takashi Onodera; Yoshinori Takahashi; Hiroshi Hanagata; Yasumitsu Ogra; Hiroaki Takagi; Hiroko Kodama; Kazuo T Suzuki; Eisuke Munekata; Akiyoshi Fukamizu
A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p.
Biochemical and biophysical research communications 2004;324(4):1379-85.
2004: Sachie Asada; Yoko Takanami-Ohnishi; Jing Zhou; Hiroshi Hama; Akiyoshi Fukamizu; Sadao Kimura; Katsutoshi Goto; Yoshitoshi Kasuya
Cytodifferentiation enhances Erk activation induced by endothelin-1 in primary cultured astrocytes.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S307-12.
2004: Atsuko Kamijo; Takeshi Sugaya; Akihisa Hikawa; Mitsuhiro Okada; Fumikazu Okumura; Masaya Yamanouchi; Akiko Honda; Masaru Okabe; Tomoya Fujino; Yasunobu Hirata; Masao Omata; Ritsuko Kaneko; Hiroshi Fujii; Akiyoshi Fukamizu; Kenjiro Kimura
Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules.
The American journal of pathology 2004;165(4):1243-55.
2004: Reiko Mochizuki-Sakisaka; Minori Dateki; Yasuyuki Ishizuka; Kazuyuki Yanai; Yoichi Matsuda; Yoshihiko Koga; Akiyoshi Fukamizu
Structural organization of the mouse neurochondrin gene.
International journal of molecular medicine 2004;14(3):361-6.
2004: Yuichi Kunori; Naoki Hase; Takashi Kawamura; Hiroaki Sato; Hidenori Kasai; Yumiko Muroga; TAKASHI KAMIMURA; Akiyoshi Fukamizu
Generation and characterization of new monoclonal antibodies against human chymase.
Hybridoma and hybridomics 2004;23(4):237-43.
2004: Hiroaki Daitoku; Mitsutoki Hatta; Hitomi Matsuzaki; Satoko Aratani; Takayuki Ohshima; Makoto Miyagishi; Toshihiro Nakajima; Akiyoshi Fukamizu
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10042-7.
2004: Keiko Sato; Minoru Kihara; Tatsuo Hashimoto; Kei Matsushita; Yu-Ichi Koide; Koichi Tamura; Nobuhito Hirawa; Yoshiyuki Toya; Akiyoshi Fukamizu; Satoshi Umemura
Alterations in renal endothelial nitric oxide synthase expression by salt diet in angiotensin type-1a receptor gene knockout mice.
Journal of the American Society of Nephrology : JASN 2004;15(7):1756-63.
2004: Junji Ishida; Tatsuo Hashimoto; Yasumi Hashimoto; Shiro Nishiwaki; Taku Iguchi; Shuichi Harada; takeshi sugaya; Hitomi Matsuzaki; Rie Yamamoto; Naotaka Shiota; Hideki Okunishi; Minoru Kihara; Satoshi Umemura; Fumihiro Sugiyama; Ken-ichi Yagami; Yoshitoshi Kasuya; Naoki Mochizuki; Akiyoshi Fukamizu
Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo.
The Journal of biological chemistry 2004;279(25):26274-9.
2004: Yunzeng Zou; Hiroshi Akazawa; Yingjie Qin; Masanori Sano; Hiroyuki Takano; Tohru Minamino; Noriko Makita; Koji Iwanaga; Weidong Zhu; Sumiyo Kudoh; Haruhiro Toko; Koichi Tamura; Minoru Kihara; Toshio Nagai; Akiyoshi Fukamizu; Satoshi Umemura; Taroh Iiri; Toshiro Fujita; Issei Komuro
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.
Nature cell biology 2004;6(6):499-506.
2004: Kazuyuki Yamagata; Hiroaki Daitoku; Yoko Shimamoto; Hitomi Matsuzaki; Keiko Hirota; Junji Ishida; Akiyoshi Fukamizu
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.
The Journal of biological chemistry 2004;279(22):23158-65.
2004: Yoko Shimamoto; Keiko Hirota; Akiyoshi Fukamizu
Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter.
International journal of molecular medicine 2004;13(5):729-33.
2004: Shoichi Date; Yutaka Nibu; Kazuyuki Yanai; Jun Hirata; Ken-ichi Yagami; Akiyoshi Fukamizu
Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene.
International journal of molecular medicine 2004;13(5):637-42.
2004: Hirokazu Ohashi; Hitoshi Takagi; Hideyasu Oh; Kiyoshi Suzuma; Izumi Suzuma; Noriko Miyamoto; Akiyoshi Uemura; Daisuke Watanabe; Tomoaki Murakami; takeshi sugaya; Akiyoshi Fukamizu; Yoshihito Honda
Phosphatidylinositol 3-kinase/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity.
Circulation research 2004;94(6):785-93.
2004: Tomohiro Ide; Hitoshi Shimano; Naoya Yahagi; Takashi Matsuzaka; Masanori Nakakuki; Takashi Yamamoto; Yoshimi Nakagawa; Akimitsu Takahashi; Hiroaki Suzuki; Hirohito Sone; Hideo Toyoshima; Akiyoshi Fukamizu; Nobuhiro Yamada
SREBPs suppress IRS-2-mediated insulin signalling in the liver.
Nature cell biology 2004;6(4):351-7.
2004: Masaki Ieda; Keiichi Fukuda; Yasuyo Hisaka; Kensuke Kimura; Haruko Kawaguchi; Jun Fujita; Kouji Shimoda; Eiko Takeshita; Hideyuki Okano; Yukiko Kurihara; Hiroki Kurihara; Junji Ishida; Akiyoshi Fukamizu; Howard Federoff; Satoshi Ogawa
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression.
The Journal of clinical investigation 2004;113(6):876-84.
2004: Yoko Shimamoto; Junji Ishida; Kazuyuki Yamagata; Tomoko Saito; Hideki Kato; Toshiki Matsuoka; Keiko Hirota; Hiroaki Daitoku; Masaomi Nangaku; Kazuya Yamagata; Hiroshi Fujii; Jun Takeda; Akiyoshi Fukamizu
Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene.
The Journal of biological chemistry 2004;279(9):7770-6.
2004: Minori Dateki; Reiko Mochizuki; Kazuyuki Yanai; Akiyoshi Fukamizu
Identification of the mouse neurochondrin promoter region and the responsible region for cell type specific gene regulation.
Neuroscience letters 2004;356(2):107-10.
2004: Tomoko Saito; Junji Ishida; Eriko Takimoto-Ohnishi; Shoko Takamine; Taku Shimizu; takeshi sugaya; Hideki Kato; Toshiki Matsuoka; Masaomi Nangaku; Yasuhiro Kon; Fumihiro Sugiyama; Ken-ichi Yagami; Akiyoshi Fukamizu
An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):388-90.
2004: Yuhao Li; Ichiro Kishimoto; Yoshihiko Saito; Masaki Harada; Koichiro Kuwahara; Takehiko Izumi; Ichiro Hamanaka; Nobuki Takahashi; Rika Kawakami; Keiji Tanimoto; Yasuaki Nakagawa; Michio Nakanishi; Yuichiro Adachi; David L Garbers; Akiyoshi Fukamizu; Kazuwa Nakao
Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A.
Endocrinology 2004;145(2):951-8.
2004: Shinichi Maki; Takashi Miyauchi; Yoshihiko Kakinuma; Satoshi Sakai; Tsutomu Kobayashi; Fumihiro Sugiyama; Akiyoshi Fukamizu; Katsutoshi Goto; Iwao Yamaguchi
The endothelin receptor antagonist ameliorates the hypertensive phenotypes of transgenic hypertensive mice with renin-angiotensin genes and discloses roles of organ specific activation of endothelin system in transgenic mice.
Life sciences 2004;74(9):1105-18.
2003: Keiji Tanimoto; Akiko Sugiura; Akane Omori; Gary Felsenfeld; James Douglas Engel; Akiyoshi Fukamizu
Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells.
Molecular and cellular biology 2003;23(24):8946-52.
2003: Hirokazu Okada; Yusuke Watanabe; Tsutomu Inoue; Tatsuya Kobayashi; Yoshihiko Kanno; Goshi Shiota; Toshikazu Nakamura; takeshi sugaya; Akiyoshi Fukamizu; Hiromichi Suzuki
Transgene-derived hepatocyte growth factor attenuates reactive renal fibrosis in aristolochic acid nephrotoxicity.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(12):2515-23.
2003: Reiko Mochizuki; Minori Dateki; Kazuyuki Yanai; Yasuyuki Ishizuka; Norio Amizuka; Hiroyuki Kawashima; Yoshihiko Koga; Hidehiro Ozawa; Akiyoshi Fukamizu
Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality.
Biochemical and biophysical research communications 2003;310(4):1219-26.
2003: Tetsuya Amano; Satoshi Yamasaki; Naoko Yagishita; Kaneyuki Tsuchimochi; Hiroshi Shin; Ko-ichi Kawahara; Satoko Aratani; Hidetoshi Fujita; Lei Zhang; Rie Ikeda; Ryoji Fujii; Naoki Miura; Setsuro Komiya; Kusuki Nishioka; Ikuro Maruyama; Akiyoshi Fukamizu; Toshihiro Nakajima
Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy.
Genes & development 2003;17(19):2436-49.
2003: Masahiro Fukuoka; Hiroaki Daitoku; Mitsutoki Hatta; Hitomi Matsuzaki; Satoshi Umemura; Akiyoshi Fukamizu
Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation.
International journal of molecular medicine 2003;12(4):503-8.
2003: Hitomi Matsuzaki; Hiroaki Daitoku; Mitsutoki Hatta; Keiji Tanaka; Akiyoshi Fukamizu
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11285-90.
2003: Satoko Aratani; Ryouji Fujii; Hidetoshi Fujita; Akiyoshi Fukamizu; Toshihiro Nakajima
Aromatic residues are required for RNA helicase A mediated transactivation.
International journal of molecular medicine 2003;12(2):175-80.
2003: Tomoko Saito; Takayuki Oishi; Kazuyuki Yanai; Yoko Shimamoto; Akiyoshi Fukamizu
Cloning and characterization of a novel splicing isoform of USF1.
International journal of molecular medicine 2003;12(2):161-7.
2003: Sayuri Uehara; Minoru Tsuchida; Tetsuya Kanno; Minoru Sasaki; Masaru Nishikibe; Akiyoshi Fukamizu
Late-onset obesity in mice transgenic for the human renin gene.
International journal of molecular medicine 2003;11(6):723-7.
2003: Keiko Hirota; Hiroaki Daitoku; Hitomi Matsuzaki; Natsumi Araya; Kazuyuki Yamagata; Sachie Asada; takeshi sugaya; Akiyoshi Fukamizu
Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor.
The Journal of biological chemistry 2003;278(15):13056-60.
2003: Hidetoshi Fujita; Ryouji Fujii; Satoko Aratani; Tetsuya Amano; Akiyoshi Fukamizu; Toshihiro Nakajima
Antithetic effects of MBD2a on gene regulation.
Molecular and cellular biology 2003;23(8):2645-57.
2003: Izumi Nishinokubi; Masami Shimoda; Koichiro Kako; Takaomi Sakai; Akiyoshi Fukamizu; Norio Ishida
Highly conserved Drosophila ananassae timeless gene functions as a clock component in Drosophila melanogaster.
Gene 2003;307():183-90.
2003: Hiroaki Daitoku; Kazuyuki Yamagata; Hitomi Matsuzaki; Mitsutoki Hatta; Akiyoshi Fukamizu
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.
Diabetes 2003;52(3):642-9.
2003: Natsumi Araya; Keiko Hirota; Yoko Shimamoto; Makoto Miyagishi; Eisaku Yoshida; Junji Ishida; Setsuko Kaneko; Michio Kaneko; Toshihiro Nakajima; Akiyoshi Fukamizu
Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription.
The Journal of biological chemistry 2003;278(7):5427-32.
2002: Yuichi Kunori; Masahiro Koizumi; Tsukio Masegi; Hidenori Kasai; Hiroshi Kawabata; Yuzo Yamazaki; Akiyoshi Fukamizu
Rodent alpha-chymases are elastase-like proteases.
European journal of biochemistry / FEBS 2002;269(23):5921-30.
2002: Masayuki Sano; Tomoko Kuwabara; Masaki Warashina; Akiyoshi Fukamizu; Kazunari Taira
Novel method for selection of tRNA-driven ribozymes with enhanced stability in mammalian cells.
Antisense & nucleic acid drug development 2002;12(5):341-52.
2002: Yuhao Li; Ichiro Kishimoto; Yoshihiko Saito; Masaki Harada; Koichiro Kuwahara; Takehiko Izumi; Nobuki Takahashi; Rika Kawakami; Keiji Tanimoto; Yasuaki Nakagawa; Michio Nakanishi; Yuichiro Adachi; David L Garbers; Akiyoshi Fukamizu; Kazuwa Nakao
Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart.
Circulation 2002;106(13):1722-8.
2002: Minako Nakazawa; Satoko Aratani; Mitsutoki Hatta; Natsumi Araya; Hiroaki Daitoku; Ko-Ichi Kawahara; Shin-Ichi Watanabe; Hiroshi Nakamura; Shin-Ichi Yoshino; Ryouji Fujii; Hidetoshi Fujita; Akiyoshi Fukamizu; Kusuki Nishioka; Toshihiro Nakajima
TNFalpha induces acetylation of p53 but attenuates its transcriptional activation in rheumatoid synoviocytes.
International journal of molecular medicine 2002;10(3):269-75.
2002: Ningling Kang; Thomas Walther; Xiao-Li Tian; Jürgen Bohlender; Akiyoshi Fukamizu; Detlev Ganten; Michael Bader
Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis.
Journal of molecular medicine (Berlin, Germany) 2002;80(6):359-66.
2002: Yoshinori Takahashi; Koichiro Kako; Hidenori Arai; Takahiro Ohishi; Yoshiko Inada; Akio Takehara; Akiyoshi Fukamizu; Eisuke Munekata
Characterization and identification of promoter elements in the mouse COX17 gene.
Biochimica et biophysica acta 2002;1574(3):359-64.
2002: Masayuki Saitoh; Ryoichi Takayanagi; Kiminobu Goto; Akiyoshi Fukamizu; Arihiro Tomura; Toshihiko Yanase; Hajime Nawata
The presence of both the amino- and carboxyl-terminal domains in the AR is essential for the completion of a transcriptionally active form with coactivators and intranuclear compartmentalization common to the steroid hormone receptors: a three-dimensional imaging study.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):694-706.
2002: Hisashi Kawabata; Ko-ichi Kawahara; Takuro Kanekura; Natsumi Araya; Hiroaki Daitoku; Mitsutoki Hatta; Naoki Miura; Akiyoshi Fukamizu; Tamotsu Kanzaki; Ikuro Maruyama; Toshihiro Nakajima
Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation.
The Journal of biological chemistry 2002;277(10):8099-105.
2002: Mitsutoki Hatta; Hiroaki Daitoku; Hitomi Matsuzaki; Yoshiaki Deyama; Yoshitaka Yoshimura; Kuniaki Suzuki; Akira Matsumoto; Akiyoshi Fukamizu
Regulation of alkaline phosphatase promoter activity by forkhead transcription factor FKHR.
International journal of molecular medicine 2002;9(2):147-52.
2001: Naoki Yamamoto; Shigeru Yamamoto; F Inagaki; M Kawaichi; Akiyoshi Fukamizu; N Kishi; K Matsuno; Kozo Nakamura; G Weinmaster; Hideyuki Okano; Masato Nakafuku
Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.
The Journal of biological chemistry 2001;276(48):45031-40.
2001: Y Takanami-Ohnishi; S Asada; H Tsunoda; Akiyoshi Fukamizu; Katsutoshi Goto; Hideki Yoshikawa; Takekazu Kubo; T Sudo; Sumiko Kimura; Y Kasuya
Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition.
Biochemical and biophysical research communications 2001;288(5):1155-61.
2001: Yasutake Katoh; Ken Itoh; Eisaku Yoshida; Makoto Miyagishi; Akiyoshi Fukamizu; Masayuki Yamamoto
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(10):857-68.
2001: Hiroaki Daitoku; J Isida; Kae Fujiwara; Toshihiro Nakajima; Akiyoshi Fukamizu
Dimerization of small GTPase Rab5.
International journal of molecular medicine 2001;8(4):397-404.
2001: Satoko Aratani; R Fujii; T Oishi; H Fujita; T Amano; T Ohshima; M Hagiwara; Akiyoshi Fukamizu; Toshihiro Nakajima
Dual roles of RNA helicase A in CREB-dependent transcription.
Molecular and cellular biology 2001;21(14):4460-9.
2001: R Fujii; M Okamoto; Satoko Aratani; T Oishi; T Ohshima; Kazunari Taira; M Baba; Akiyoshi Fukamizu; Toshihiro Nakajima
A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1.
The Journal of biological chemistry 2001;276(8):5445-51.
2001: Jing Zhou; Kayoko Moroi; Mariko Nishiyama; Hirokazu Usui; N Seki; J Ishida; Akiyoshi Fukamizu; Sadao Kimura
Characterization of RGS5 in regulation of G protein-coupled receptor signaling.
Life sciences 2001;68(13):1457-69.
2001: T Ohshima; Eisaku Yoshida; Toshihiro Nakajima; Ken-ichi Yagami; Akiyoshi Fukamizu
Effects of interaction between parvovirus minute virus of mice NS1 and coactivator CBP on NS1- and p53-transactivation.
International journal of molecular medicine 2001;7(1):49-54.
2001: Minako Nakazawa; H Ishii; Hiroshi Nakamura; Shin-Ichi Yoshino; Akiyoshi Fukamizu; Kusuki Nishioka; Toshihiro Nakajima
NFkappaB2 (p52) promoter activation via Notch signaling pathway in rheumatoid synoviocytes.
International journal of molecular medicine 2001;7(1):31-5.
2000: Shin-ichi Kashiwabara; Tiangang Zhuang; Kazuo Yamagata; Junko Noguchi; Akiyoshi Fukamizu; Tadashi Baba
Identification of a novel isoform of poly(A) polymerase, TPAP, specifically present in the cytoplasm of spermatogenic cells.
Developmental biology 2000;228(1):106-15.
2000: Makoto Miyagishi; R Fujii; Mitsutoki Hatta; Eisaku Yoshida; Natsumi Araya; A Nagafuchi; S Ishihara; Toshihiro Nakajima; Akiyoshi Fukamizu
Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300.
The Journal of biological chemistry 2000;275(45):35170-5.
2000: Akiyoshi Fukamizu
Genomic expression systems on hierarchy and network leading to hypertension: long on history, short on facts.
Hypertension research : official journal of the Japanese Society of Hypertension 2000;23(6):545-52.
2000: Hirokazu Usui; Mariko Nishiyama; Kayoko Moroi; T Shibasaki; Jing Zhou; J Ishida; Akiyoshi Fukamizu; T Haga; S Sekiya; Sadao Kimura
RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling.
International journal of molecular medicine 2000;5(4):335-40.
2000: Fumihiro Sugiyama; Ken-ichi Yagami; Akiyoshi Fukamizu
[Transgenic models for human hypertension].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 2():721-4.
2000: Kazuyuki Yanai; Tomoko Saito; Y Kakinuma; Y Kon; Keiko Hirota; K Taniguchi-Yanai; N Nishijo; Y Shigematsu; H Horiguchi; Yoshitoshi Kasuya; Fumihiro Sugiyama; Ken-ichi Yagami; K Murakami; Akiyoshi Fukamizu
Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice.
The Journal of biological chemistry 2000;275(1):5-8.
2000: M Miyagishi; Toshihiro Nakajima; Akiyoshi Fukamizu
Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin.
International journal of molecular medicine 2000;5(1):27-31.
1999: K Kawahara; S Watanabe; T Ohshima; Y Soejima; T Oishi; S Aratani; Masanori Nakata; M Shibata; K Inoue; T Amano; R Fujii; K Yanai; M Hagiwara; Akiyoshi Fukamizu; Ikuro Maruyama; Toshihiro Nakajima
Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells.
Biochemical and biophysical research communications 1999;266(2):417-24.
1999: Kazuyuki Yanai; Keiko Hirota; K Taniguchi-Yanai; Y Shigematsu; Yoko Shimamoto; Tomoko Saito; S Chowdhury; M Takiguchi; M Arakawa; Yutaka Nibu; Fumihiro Sugiyama; Ken-ichi Yagami; Akiyoshi Fukamizu
Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor.
The Journal of biological chemistry 1999;274(49):34605-12.
1999: Reiko Mochizuki; Y Ishizuka; K Yanai; Y Koga; Akiyoshi Fukamizu; K Murakami
Molecular cloning and expression of human neurochondrin-1 and -2.
Biochimica et biophysica acta 1999;1446(3):397-402.
1999: N Nishijo; S Takamine; Fumihiro Sugiyama; K Kimoto; K Taniguchi; H Horiguchi; T Ogata; K Murakami; Akiyoshi Fukamizu; Ken-ichi Yagami
Vascular remodeling in hypertensive transgenic mice.
Experimental animals / Japanese Association for Laboratory Animal Science 1999;48(3):203-8.
1999: Y Ishiduka; Reiko Mochizuki; K Yanai; M Takatsuka; T Nonomura; S Niida; H Horiguchi; N Maeda; Akiyoshi Fukamizu
Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin.
Biochimica et biophysica acta 1999;1450(1):92-8.
1999: Akiyoshi Fukamizu
[Angiotensin and arteriosclerosis: an approach from transgenic and knockout mice].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(5):1176-81.
1999: J Ishida; Akiyoshi Fukamizu
[Angiotensin II and apoptosis].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(5):1117-23.
1999: Junji Ishida; Sachie Asada; Hiroaki Daitoku; Kae Fujiwara; Y Kon; T Sugaya; K Murakami; Toshihiro Nakajima; Yoshitoshi Kasuya; Akiyoshi Fukamizu
Expression and characterization of mouse angiotensin II type 1a receptor tagging hemagglutinin epitope in cultured cells.
International journal of molecular medicine 1999;3(3):263-70.
1998: Junji Ishida; Fumihiro Sugiyama; K Tanimoto; K Taniguchi; M Syouji; E Takimoto; H Horiguchi; K Murakami; Ken-ichi Yagami; Akiyoshi Fukamizu
Rescue of angiotensinogen-knockout mice.
Biochemical and biophysical research communications 1998;252(3):610-6.
1998: N Nishijo; Fumihiro Sugiyama; K Kimoto; K Taniguchi; K Murakami; S Suzuki; Akiyoshi Fukamizu; Ken-ichi Yagami
Salt-sensitive aortic aneurysm and rupture in hypertensive transgenic mice that overproduce angiotensin II.
Laboratory investigation; a journal of technical methods and pathology 1998;78(9):1059-66.
1998: Kouichi Tamura; Satoshi Umemura; Y Sumida; N Nyui; S Kobayashi; Tomoaki Ishigami; Minoru Kihara; T Sugaya; Akiyoshi Fukamizu; H Miyazaki; K Murakami; M Ishii
Effect of genetic deficiency of angiotensinogen on the renin-angiotensin system.
Hypertension 1998;32(2):223-7.
1998: Kouichi Tamura; Satoshi Umemura; N Nyui; Machiko Yabana; Yoshiyuki Toya; Akiyoshi Fukamizu; K Murakami; M Ishii
Possible role of c-Jun in transcription of the mouse renin gene.
Kidney international 1998;54(2):382-93.
1998: Naotaka Shiota; Akiyoshi Fukamizu; Hideki Okunishi; Shinji Takai; K Murakami; Mizuo Miyazaki
Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts.
The Biochemical journal 1998;333 ( Pt 2)():417-24.
1998: Minoru Kihara; Satoshi Umemura; T Sugaya; Yoshiyuki Toya; Machiko Yabana; S Kobayashi; Kouichi Tamura; Tetsuo Kadota; Reiji Kishida; K Murakami; Akiyoshi Fukamizu; M Ishii
Expression of neuronal type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensin type-1a receptor gene-knockout mice.
Kidney international 1998;53(6):1585-93.
1998: K Taniguchi; Fumihiro Sugiyama; Y Kakinuma; S Uehara; N Nishijho; K Tanimoto; K Murakami; Akiyoshi Fukamizu; Ken-ichi Yagami
Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice.
International journal of molecular medicine 1998;1(3):583-7.
1998: Satoshi Umemura; Minoru Kihara; Y Sumida; Machiko Yabana; Tomoaki Ishigami; Kouichi Tamura; N Nyui; Kiyoshi Hibi; K Murakami; Akiyoshi Fukamizu; M Ishii
Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading.
Journal of hypertension 1998;16(3):285-9.
1998: Minoru Kihara; Satoshi Umemura; Machiko Yabana; Y Sumida; N Nyui; Kouichi Tamura; Tetsuo Kadota; Reiji Kishida; K Murakami; Akiyoshi Fukamizu; M Ishii
Dietary salt loading decreases the expressions of neuronal-type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice.
Journal of the American Society of Nephrology : JASN 1998;9(3):355-62.
1998: Minoru Kihara; Satoshi Umemura; Y Sumida; N Yokoyama; Machiko Yabana; N Nyui; Kouichi Tamura; K Murakami; Akiyoshi Fukamizu; M Ishii
Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice.
Kidney international 1998;53(3):548-55.
1998: E Yoshida; Toshihiro Nakajima; K Murakami; Akiyoshi Fukamizu
Identification of N-terminal minimal transactivation domain of CBP, p300 and caenorhabditis elegans homologues.
Gene 1998;208(2):307-14.
1998: E Yoshida; K Tanimoto; K Murakami; Akiyoshi Fukamizu
Isolation and characterization of 5'-regulatory region of mouse activin beta A subunit gene.
Biochemistry and molecular biology international 1998;44(2):325-32.
1998: Y Sumida; Satoshi Umemura; Kouichi Tamura; Minoru Kihara; S Kobayashi; Tomoaki Ishigami; Machiko Yabana; N Nyui; H Ochiai; Akiyoshi Fukamizu; H Miyazaki; K Murakami; M Ishii
Increased cardiac angiotensin II receptors in angiotensinogen-deficient mice.
Hypertension 1998;31(1):45-9.
1997: E Yoshida; Satoko Aratani; H Itou; Makoto Miyagishi; M Takiguchi; T Osumu; K Murakami; Akiyoshi Fukamizu
Functional association between CBP and HNF4 in trans-activation.
Biochemical and biophysical research communications 1997;241(3):664-9.
1997: Akiyoshi Fukamizu
[Genetic dissection of protease and signal transduction network].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(14 Suppl):2441-7.
1997: Fumihiro Sugiyama; Y Tanimoto; H Kato; T Nomura; K Taniguchi; K Tanimoto; K Murakami; Akiyoshi Fukamizu; Ken-ichi Yagami
Speedy backcrossing through in vitro fertilization, using pre-pubertal superovulation and neonatal death dependent on genetic background in angiotensinogen-deficient mice.
Laboratory animal science 1997;47(5):545-8.
1997: Kazuyuki Yanai; K Murakami; Akiyoshi Fukamizu
ATF-like element contributes to hepatic activation of human angiotensinogen promoter.
Biochemical and biophysical research communications 1997;237(1):158-62.
1997: Akiyoshi Fukamizu
[Molecular biology and genetics of angiotensin signal-transduction system].
Seikagaku. The Journal of Japanese Biochemical Society 1997;69(8):991-1002.
1997: Fumihiro Sugiyama; K Taniguchi; Akiyoshi Fukamizu; Ken-ichi Yagami
[Genetically engineered mice for study of human hypertension].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(8):2005-10.
1997: Kazuyuki Yanai; S Matsuyama; K Murakami; Akiyoshi Fukamizu
Differential action of AGCF2 upon cell type-dependent expression of human angiotensinogen gene.
FEBS letters 1997;412(2):285-9.
1997: Kouichi Tamura; Satoshi Umemura; N Nyui; S Yamaguchi; Tomoaki Ishigami; Kiyoshi Hibi; Machiko Yabana; Minoru Kihara; Akiyoshi Fukamizu; K Murakami; M Ishii
A novel proximal element mediates the regulation of mouse Ren-1C promoter by retinoblastoma protein in cultured cells.
The Journal of biological chemistry 1997;272(27):16845-51.
1997: N Nyui; Kouichi Tamura; Keiko Mizuno; Tomoaki Ishigami; Kiyoshi Hibi; Machiko Yabana; Minoru Kihara; Akiyoshi Fukamizu; H Ochiai; Satoshi Umemura; K Murakami; Shigeaki Ohno; M Ishii
Stretch-induced MAP kinase activation in cardiomyocytes of angiotensinogen-deficient mice.
Biochemical and biophysical research communications 1997;235(1):36-41.
1997: Fumihiro Sugiyama; S Haraoka; Teruo Watanabe; Naotaka Shiota; K Taniguchi; Y Ueno; K Tanimoto; K Murakami; Akiyoshi Fukamizu; Ken-ichi Yagami
Acceleration of atherosclerotic lesions in transgenic mice with hypertension by the activated renin-angiotensin system.
Laboratory investigation; a journal of technical methods and pathology 1997;76(6):835-42.
1997: Naotaka Shiota; Akiyoshi Fukamizu; Shinji Takai; Hideki Okunishi; K Murakami; Mizuo Miyazaki
Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart.
Journal of hypertension 1997;15(4):431-40.
1997: Akiyoshi Fukamizu; K Murakami
Activated and inactivated renin-angiotensin system in transgenic animals: from genes to blood pressure.
Laboratory animal science 1997;47(2):127-31.
1997: M Kihara; S Umemura; Tetsuo Kadota; Machiko Yabana; K Tamura; N Nyuui; N Ogawa; K Murakami; Akiyoshi Fukamizu; M Ishii
The neuronal isoform of constitutive nitric oxide synthase is up-regulated in the macula densa of angiotensinogen gene-knockout mice.
Laboratory investigation; a journal of technical methods and pathology 1997;76(2):285-94.
1997: Jürgen Bohlender; Akiyoshi Fukamizu; Andrea Lippoldt; T Nomura; R Dietz; Joël Ménard; K Murakami; F C Luft; Detlev Ganten
High human renin hypertension in transgenic rats.
Hypertension 1997;29(1 Pt 2):428-34.
1996: K Tanimoto; E Yoshida; S Mita; Yutaka Nibu; K Murakami; Akiyoshi Fukamizu
Human activin betaA gene. Identification of novel 5' exon, functional promoter, and enhancers.
The Journal of biological chemistry 1996;271(51):32760-9.
1996: E Takimoto; J Ishida; Fumihiro Sugiyama; H Horiguchi; K Murakami; Akiyoshi Fukamizu
Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen.
Science (New York, N.Y.) 1996;274(5289):995-8.
1996: M Nagata; K Tanimoto; Akiyoshi Fukamizu; Y Kon; Fumihiro Sugiyama; Ken-ichi Yagami; K Murakami; T Watanabe
Nephrogenesis and renovascular development in angiotensinogen-deficient mice.
Laboratory investigation; a journal of technical methods and pathology 1996;75(5):745-53.
1995: Y Goto; Fumihiro Sugiyama; K Tanimoto; J Ishida; M Syoji; A Takahashi; Y Sugiyama; K Murakami; Akiyoshi Fukamizu; Ken-ichi Yagami
Evaluation of coculture aggregation with TT2 cells for production of germline chimera.
Laboratory animal science 1995;45(5):601-3.
1995: S Shimada; Kazuyuki Yanai; Satoru Takahashi; K Murakami; Akiyoshi Fukamizu
Identification of two distinct Sp1- and RBF-1-like nuclear factors that bind to the upstream region of the human angiotensinogen promoter.
Endocrine 1995;3(7):543-7.
1995: Fumihiro Sugiyama; M Sagara; Y Matsuda; H Horiguchi; H Kamma; T Ogata; T Hatae; Ken-ichi Yagami; K Murakami; Akiyoshi Fukamizu
Heritable formation of neuroectodermal tumor in transgenic mice carrying the combined E1 region gene of adenovirus type 12 with the deregulated human renin promoter.
Journal of cellular biochemistry 1995;57(4):691-700.
1995: Kouichi Tamura; Satoshi Umemura; Akiyoshi Fukamizu; M Ishii; K Murakami
Recent advances in the study of renin and angiotensinogen genes: from molecules to the whole body.
Hypertension research : official journal of the Japanese Society of Hypertension 1995;18(1):7-18.
1995: M Sagara; Fumihiro Sugiyama; H Horiguchi; H Kamma; T Ogata; Ken-ichi Yagami; K Murakami; Akiyoshi Fukamizu
Activation of the nuclear oncogenes N-myc and c-jun in carcinoid [correction of cartinoid] tumors of transgenic mice carrying the human adenovirus type 12 E1 region gene.
DNA and cell biology 1995;14(2):95-101.
1994: K Tanimoto; Fumihiro Sugiyama; Y Goto; J Ishida; E Takimoto; Ken-ichi Yagami; Akiyoshi Fukamizu; K Murakami
Angiotensinogen-deficient mice with hypotension.
The Journal of biological chemistry 1994;269(50):31334-7.
1994: Yutaka Nibu; K Tanimoto; Satoru Takahashi; H Ono; K Murakami; Akiyoshi Fukamizu
A cell type-dependent enhancer core element is located in exon 5 of the human angiotensinogen gene.
Biochemical and biophysical research communications 1994;205(2):1102-8.
1994: Akiyoshi Fukamizu; M Sagara; Fumihiro Sugiyama; H Horiguchi; H Kamma; T Hatae; T Ogata; Ken-ichi Yagami; K Murakami
Neuroectodermal tumors expressing c-, L-, and N-myc in transgenic mice that carry the E1A/E1B gene of human adenovirus type 12.
The Journal of biological chemistry 1994;269(49):31252-8.
1994: Akiyoshi Fukamizu; M Watanabe; Y Inoue; Y Kon; S Shimada; N Shiota; Fumihiro Sugiyama; K Murakami
Cortical expression of the human angiotensinogen gene in the kidney of transgenic mice.
Kidney international 1994;46(6):1533-5.
1994: Yutaka Nibu; Satoru Takahashi; K Tanimoto; K Murakami; Akiyoshi Fukamizu
Identification of cell type-dependent enhancer core element located in the 3'-downstream region of the human angiotensinogen gene.
The Journal of biological chemistry 1994;269(46):28598-605.
1994: D Tomura; K Obika; Akiyoshi Fukamizu; Hirofumi Shoun
Nitric oxide reductase cytochrome P-450 gene, CYP 55, of the fungus Fusarium oxysporum containing a potential binding-site for FNR, the transcription factor involved in the regulation of anaerobic growth of Escherichia coli.
Journal of biochemistry 1994;116(1):88-94.
1994: K Tamura; S Umemura; M Ishii; K Tanimoto; K Murakami; Akiyoshi Fukamizu
Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter.
The Journal of clinical investigation 1994;93(4):1370-9.
1994: K Tanimoto; K Murakami; Akiyoshi Fukamizu
Combinatorial action of cAMP and phorbol ester on synergistic expression of the human activin A gene.
Experimental cell research 1994;211(2):408-14.
1994: Kouichi Tamura; Satoshi Umemura; T Iwamoto; S Yamaguchi; S Kobayashi; K Takeda; Y Tokita; N Takagi; K Murakami; Akiyoshi Fukamizu
Molecular mechanism of adipogenic activation of the angiotensinogen gene.
Hypertension 1994;23(3):364-8.
1994: Akiyoshi Fukamizu; M Sagara; Fumihiro Sugiyama; Ken-ichi Yagami; K Murakami
Tissue-specific trans-activation of renin gene by targeted expression of adenovirus E1A in transgenic mice.
Biochemical and biophysical research communications 1994;199(1):183-90.
1994: T Hatae; E Takimoto; K Murakami; Akiyoshi Fukamizu
Comparative studies on species-specific reactivity between renin and angiotensinogen.
Molecular and cellular biochemistry 1994;131(1):43-7.
1994: Akiyoshi Fukamizu; S Uehara; T Hatae; K Tamura; K Watanabe; Fumihiro Sugiyama; K Murakami
Species-specific expression of the hepatic renin gene.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1994;56(1):109-14.
1993: K Obika; D Tomura; Akiyoshi Fukamizu; Hirofumi Shoun
Expression of the fungal cytochrome P-450nor cDNA in Escherichia coli.
Biochemical and biophysical research communications 1993;196(3):1255-60.
1993: K Tamura; K Tanimoto; M Ishii; K Murakami; Akiyoshi Fukamizu
Proximal and core DNA elements are required for efficient angiotensinogen promoter activation during adipogenic differentiation.
The Journal of biological chemistry 1993;268(20):15024-32.
1993: Akiyoshi Fukamizu; K Sugimura; E Takimoto; Fumihiro Sugiyama; M S Seo; Satoru Takahashi; T Hatae; N Kajiwara; Ken-ichi Yagami; K Murakami
Chimeric renin-angiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human renin and human angiotensinogen genes.
The Journal of biological chemistry 1993;268(16):11617-21.
1993: S Shimada; Akiyoshi Fukamizu; K Murakami
[Developmental biotechnology and hypertension--emphasis on renin-angiotensin system].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(6):1562-7.
1993: Naotaka Shiota; Hideki Okunishi; Akiyoshi Fukamizu; Hiroshi Sakonjo; M Kikumori; T Nishimura; T Nakagawa; K Murakami; Mizuo Miyazaki
Activation of two angiotensin-generating systems in the balloon-injured artery.
FEBS letters 1993;323(3):239-42.
1993: K Tanimoto; K Murakami; Akiyoshi Fukamizu
Possible roles of the 3'-flanking sequences of the human activin beta A subunit gene in its expression.
Archives of biochemistry and biophysics 1993;302(2):409-16.
1993: K Tamura; K Tanimoto; K Murakami; Akiyoshi Fukamizu
Activation of mouse renin promoter by cAMP and c-Jun in a kidney-derived cell line.
Biochimica et biophysica acta 1993;1172(3):306-10.
1993: Akiyoshi Fukamizu; E Takimoto; K Sugimura; T Hatae; M S Seo; Satoru Takahashi; Fumihiro Sugiyama; N Kajiwara; Ken-ichi Yagami; K Murakami
Dependence of angiotensin production in transgenic mice carrying either the human renin or human angiotensinogen genes on species-specific kinetics of the renin-angiotensin system.
Arzneimittel-Forschung 1993;43(2A):222-5.
1992: Satoru Takahashi; Akiyoshi Fukamizu; T Hatae; Y Yamada; Fumihiro Sugiyama; N Kajiwara; Ken-ichi Yagami; K Murakami
Species-specific kinetics of mouse renin contribute to maintenance of normal blood pressure in transgenic mice with overexpressed human angiotensinogen.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1992;54(6):1191-3.
1992: T Hatae; E Takimoto; Akiyoshi Fukamizu; H Hori; K Kimoto; K Murakami
Expression and purification of human angiotensinogen in Chinese hamster ovary cells.
Biochimica et biophysica acta 1992;1121(3):335-8.
1992: Satoru Takahashi; Akiyoshi Fukamizu; Fumihiro Sugiyama; N Kajiwara; Ken-ichi Yagami; K Murakami
Species-specific induction of angiotensinogen mRNA in transgenic mouse liver during acute phase reaction.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1992;54(2):367-9.
1992: K Tanimoto; K Tamura; N Ueno; S Usuki; K Murakami; Akiyoshi Fukamizu
Regulation of activin beta A mRNA level by cAMP.
Biochemical and biophysical research communications 1992;182(2):773-8.
1992: Kouichi Tamura; K Tanimoto; S Takahashi; M Sagara; Akiyoshi Fukamizu; K Murakami
Structure and expression of the mouse angiotensinogen gene.
Japanese heart journal 1992;33(1):113-24.
1991: M S Seo; Akiyoshi Fukamizu; T Saito; K Murakami
Identification of a previously unrecognized production site of human renin.
Biochimica et biophysica acta 1991;1129(1):87-9.
1991: Satoru Takahashi; Akiyoshi Fukamizu; T Hasegawa; M Yokoyama; T Nomura; M Katsuki; K Murakami
Expression of the human angiotensinogen gene in transgenic mice and transfected cells.
Biochemical and biophysical research communications 1991;180(2):1103-9.
1991: H Kizawa; D Tomura; M Oda; Akiyoshi Fukamizu; T Hoshino; O Gotoh; T Yasui; Hirofumi Shoun
Nucleotide sequence of the unique nitrate/nitrite-inducible cytochrome P-450 cDNA from Fusarium oxysporum.
The Journal of biological chemistry 1991;266(16):10632-7.
1991: Akiyoshi Fukamizu; K Tanimoto; S Uehara; M S Seo; S Handa; M Sagara; Satoru Takahashi; T Imai; K Murakami
Regulation of human renin and angiotensinogen genes.
Biomedica biochimica acta 1991;50(4-6):659-63.
1991: K Tanimoto; S Handa; N Ueno; K Murakami; Akiyoshi Fukamizu
Structure and sequence analysis of the human activin beta A subunit gene.
DNA sequence : the journal of DNA sequencing and mapping 1991;2(2):103-10.
1990: Akiyoshi Fukamizu; Satoru Takahashi; M S Seo; M Tada; K Tanimoto; S Uehara; K Murakami
Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter.
The Journal of biological chemistry 1990;265(13):7576-82.
1990: M S Seo; Akiyoshi Fukamizu; T Nomura; M Yokoyama; M Katsuki; K Murakami
The human renin gene in transgenic mice.
Journal of cardiovascular pharmacology 1990;16 Suppl 4():S8-10.
1990: Akiyoshi Fukamizu; Satoru Takahashi; K Murakami
Expression of the human angiotensinogen gene in human cell lines.
Journal of cardiovascular pharmacology 1990;16 Suppl 4():S11-3.
1989: Akiyoshi Fukamizu; M S Seo; T Hatae; M Yokoyama; T Nomura; M Katsuki; K Murakami
Tissue-specific expression of the human renin gene in transgenic mice.
Biochemical and biophysical research communications 1989;165(2):826-32.
1989: Tadashi Baba; Shin-ichi Kashiwabara; K Watanabe; H Itoh; Y Michikawa; K Kimura; M Takada; Akiyoshi Fukamizu; Y Arai
Activation and maturation mechanisms of boar acrosin zymogen based on the deduced primary structure.
The Journal of biological chemistry 1989;264(20):11920-7.
1989: M Tada; Akiyoshi Fukamizu; M S Seo; Satoru Takahashi; K Murakami
Renin expression in the kidney and brain is reciprocally controlled by captopril.
Biochemical and biophysical research communications 1989;159(3):1065-71.