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Shoji Fukushima

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Kenjiro Tatematsu; Keiichirou Morimura; Shoji Fukushima; Akihiro Koide; Yukio Mori
The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus.
Min Wei; Shotaro Yamano; Anna Kakehashi; Tomoyuki Shirai; Seiko Tamano; Hideki Wanibuchi; Shoji Fukushima
Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens.
Anna Kakehashi; Yui Sokuza; Yoshiyuki Tago; Min Wei; Midori Yoshida; Shoji Fukushima; Hideki Wanibuchi
Hormonally active doses of isoflavone aglycones promote mammary and endometrial carcinogenesis and alter the molecular tumor environment in Donryu rats.

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2013: Kenjiro Tatematsu; Keiichirou Morimura; Shoji Fukushima; Akihiro Koide; Yukio Mori
The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P450 2A in the rat oesophagus.
Mutagenesis 2013;28(2):161-9.
2012: Min Wei; Shotaro Yamano; Anna Kakehashi; Tomoyuki Shirai; Seiko Tamano; Hideki Wanibuchi; Shoji Fukushima
Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens.
Journal of toxicologic pathology 2012;25(3):209-14.
2012: Anna Kakehashi; Yui Sokuza; Yoshiyuki Tago; Min Wei; Midori Yoshida; Shoji Fukushima; Hideki Wanibuchi
Hormonally active doses of isoflavone aglycones promote mammary and endometrial carcinogenesis and alter the molecular tumor environment in Donryu rats.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(1):39-51.
2011: Yaowares Chusiri; Rawiwan Wongpoomchai; Anna Kakehashi; Min Wei; Hideki Wanibuchi; Usanee Vinitketkumnuan; Shoji Fukushima
Non-genotoxic mode of action and possible threshold for hepatocarcinogenicity of Kojic acid in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(2):471-6.
2011: Min Wei; Hideki Wanibuchi; Dai Nakae; Hiroyuki Tsuda; Satoru Takahashi; Masao Hirose; Yukari Totsuka; Masae Tatematsu; Shoji Fukushima
Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip / WAF1).
Cancer science 2011;102(1):88-94.
2011: Anna Kakehashi; Naomi Ishii; Takeshi Shibata; Min Wei; Etsuko Okazaki; Taro Tachibana; Shoji Fukushima; Hideki Wanibuchi
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.
Toxicological sciences : an official journal of the Society of Toxicology 2011;119(1):61-72.
2010: Kenichiro Doi; Kuniyoshi Sakai; Reiko Tanaka; Kaori Toma; Takashi Yamaguchi; Min Wei; Shoji Fukushima; Hideki Wanibuchi
Chemopreventive effects of 13alpha,14alpha-epoxy-3beta-methoxyserratan-21beta-ol (PJJ-34), a serratane-type triterpenoid, in a rat multi-organ carcinogenesis bioassay.
Cancer letters 2010;289(2):161-9.
2009: Tokuo Sukata; Kayo Sumida; Satoshi Uwagawa; Hideki Wanibuchi; Anna Kakehashi; Masahiko Kushida; Kaori Miyata; Keiko Ogata; Keisuke Ozaki; Shoji Fukushima
Characteristic upregulation of glucose-regulated protein 78 in an early lesion negative for hitherto established cytochemical markers in rat hepatocarcinogenesis.
Journal of toxicologic pathology 2009;22(4):281-8.
2009: Min Wei; Al-Salmy Hamoud; Takashi Yamaguchi; Anna Kakehashi; Keiichirou Morimura; Kenichiro Doi; Masahiko Kushida; Mitsuaki Kitano; Hideki Wanibuchi; Shoji Fukushima
Potassium bromate enhances N-ethyl-N-hydroxyethylnitrosamine-induced kidney carcinogenesis only at high doses in Wistar rats: indication of the existence of an enhancement threshold.
Toxicologic pathology 2009;37(7):983-91.
2009: Alina Romanenko; Anna Kakehashi; Keiichirou Morimura; Hideki Wanibuchi; Min Wei; Alexander Vozianov; Shoji Fukushima
Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident.
Carcinogenesis 2009;30(11):1821-31.
2009: Anna Kakehashi; Masayo Inoue; Min Wei; Shoji Fukushima; Hideki Wanibuchi
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.
Toxicology and applied pharmacology 2009;238(1):71-9.
2009: Masahiko Kushida; Kaori Miyata; Keiko Ogata; Keisuke Ozaki; Tokuo Sukata; Satoshi Uwagawa; Hideki Wanibuchi; Min Wei; Anna Kakehashi; Shoji Fukushima
Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker.
Journal of toxicologic pathology 2009;22(1):65-70.
2008: Elsayed I. Salim; Keiichirou Morimura; Ahmed Menesi; Mohammed El-Lity; Shoji Fukushima; Hideki Wanibuchi
Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis.
International journal of cancer. Journal international du cancer 2008;123(3):601-8.
2008: Jin Seok Kang; Hideki Wanibuchi; Keiichirou Morimura; Rawiwan Wongpoomchai; Yaowares Chusiri; Frank J Gonzalez; Shoji Fukushima
Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity.
Toxicology and applied pharmacology 2008;228(3):295-300.
2008: Takashi Yamaguchi; Min Wei; Natsuko Hagihara; Masako Omori; Hideki Wanibuchi; Shoji Fukushima
Lack of mutagenic and toxic effects of low dose potassium bromate on kidneys in the Big Blue rat.
Mutation research 2008;652(1):1-11.
2008: Kenichiro Fukuhara; Harushi Osugi; Masashi Takemura; Shigeru Lee; Keiichirou Morimura; Takayuki Nishikawa; Hiroshi Iwasaki; Shoji Fukushima; Shigefumi Suehiro
Expression of 8-hydroxydeoxyguanosine in the gastric remnant after distal gastrectomy.
Hepato-gastroenterology 2008;55(82-83):508-11.
2007: Jin Seok Kang; Hideki Wanibuchi; Keiichirou Morimura; Frank J Gonzalez; Shoji Fukushima
Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.
Cancer research 2007;67(23):11141-6.
2007: Anna Kakehashi; Hideki Wanibuchi; Min Wei; Takayuki Yunoki; Shoji Fukushima
Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder.
Toxicology and applied pharmacology 2007;221(3):295-305.
2007: Anna Kakehashi; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Dai Nakae; Tsuyoshi Arai; Osamu Minowa; Tetsuo Noda; Susumu Nishimura; Shoji Fukushima
Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice.
Cancer science 2007;98(6):803-14.
2007: Jin Seok Kang; Hideki Wanibuchi; Takashi Murai; Keiichirou Morimura; Anna Kakehashi; Shoji Fukushima
Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis.
Oncology reports 2007;17(4):747-52.
2007: Jin Seok Kang; Hideki Wanibuchi; Elsayed I. Salim; Anna Kakehashi; Shoji Fukushima
Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(3):494-501.
2007: Shuji Iwai; Takashi Murai; Susumu Makino; Wei Min; Keiichirou Morimura; Satoru Mori; Atsushi Hagihara; Shuichi Seki; Shoji Fukushima
High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice.
Cancer letters 2007;246(1-2):115-21.
2007: Kenichiro Doi; Atsushi Hagihara; Min Wei; Takayuki Yunoki; Shoji Fukushima; Hideki Wanibuchi
Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model.
Oncology 2007;73(3-4):252-60.
2007: John I Anetor; Hideki Wanibuchi; Shoji Fukushima
Arsenic exposure and its health effects and risk of cancer in developing countries: micronutrients as host defence.
Asian Pacific journal of cancer prevention : APJCP 2007;8(1):13-23.
2006: Alina Romanenko; Keiichirou Morimura; Anna Kakehashi; Hideki Wanibuchi; Satoru Takahashi; Wadim K Zaparin; Wladimir I Vinnichenko; Alexander Vozianov; Shoji Fukushima
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.
Cancer science 2006;97(11):1168-74.
2006: Rawiwan Puatanachokchai; Keiichirou Morimura; Hideki Wanibuchi; Mayuko Oka; Anna Kakehashi; Fukui Mitsuru; Shuji Yamaguchi; Yoshihiko Funae; Shoji Fukushima
Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes.
Cancer letters 2006;240(1):102-13.
2006: Shoji Fukushima; Hideki Wanibuchi; Min Wei; Keiichirou Morimura
[Development of invasive urinary bladder carcinomas].
Hinyokika kiyo. Acta urologica Japonica 2006;52(6):451-5.
2006: Mitsuaki Kitano; Jutaro Wada; Yutaka Ariki; Masanori Kato; Hideki Wanibuchi; Keiichirou Morimura; Takayoshi Hidaka; Kazunori Hosoe; Shoji Fukushima
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis.
Cancer science 2006;97(6):478-83.
2006: Jin Seok Kang; Hideki Wanibuchi; Keiichirou Morimura; Yukari Totsuka; Isao Yoshimura; Shoji Fukushima
Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats.
Cancer science 2006;97(6):453-8.
2006: Motome Nishikawa-Ogawa; Hideki Wanibuchi; Keiichirou Morimura; Anna Kakehashi; Takayuki Nishikawa; Shuji Hayashi; Yoshihisa Yano; Shoji Fukushima
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.
Carcinogenesis 2006;27(5):982-8.
2006: Rawiwan Puatanachokchai; Masakazu Kakuni; Hideki Wanibuchi; Anna Kakehashi; Jin Seok Kang; Elsayed I. Salim; Keiichirou Morimura; Seiko Tamano; Glenn T Merlino; Shoji Fukushima
Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic mice.
Asian Pacific journal of cancer prevention : APJCP 2006;7(2):274-8.
2006: Jin Seok Kang; Keiichirou Morimura; Chitose Toda; Hideki Wanibuchi; Min Wei; Nakao Kojima; Shoji Fukushima
Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage.
Reproductive toxicology (Elmsford, N.Y.) 2006;21(3):253-9.
2006: Alina Romanenko; Anna Kakehashi; Hideki Wanibuchi; Min Wei; Wadim K Zaparin; Wladimir I Vinnichenko; Alexander Vozianov; Shoji Fukushima
Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans.
The Journal of urology 2006;175(2):739-43.
2006: Jun Shen; Hideki Wanibuchi; Michael P Waalkes; Elsayed I. Salim; Anna Kakehashi; Kaoru Yoshida; Ginji Endo; Shoji Fukushima
A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response.
Toxicology and applied pharmacology 2006;210(3):171-80.
2006: Min Wei; Taka-Aki Hori; Toshio Ichihara; Hideki Wanibuchi; Keiichirou Morimura; Jin Seok Kang; Rawiwan Puatanachokchai; Shoji Fukushima
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats.
Cancer letters 2006;231(2):304-8.
2006: Masahiko Kushida; Sigetoshi Aiso; Keiichirou Morimura; Min Wei; Hideki Wanibuchi; Kasuke Nagano; Shoji Fukushima
Absence of beta-catenin alteration in hepatic tumors induced by p-nitroanisole in Crj:BDF1 mice.
Toxicologic pathology 2006;34(3):237-42.
2006: Hideki Wanibuchi; Min Wei; M Rezaul Karim; Keiichirou Morimura; Kenichiro Doi; Anna Kakehashi; Shoji Fukushima
Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol.
Toxicologic pathology 2006;34(3):232-6.
2006: Hideki Wanibuchi; Yonghong Zhang; Anna Kakehashi; Min Wei; Jin Seok Kang; Shoji Fukushima
Effects of cessation of alcohol exposure on rat hepatocarcinogenesis.
Asian Pacific journal of cancer prevention : APJCP 2006;7(1):122-6.
2006: Hideki Wanibuchi; Min Wei; Elsayed I. Salim; Anna Kakehashi; Keiichirou Morimura; Katsuichi Sudo; Shoji Fukushima
Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470.
Asian Pacific journal of cancer prevention : APJCP 2006;7(1):101-7.
2006: Alina Romanenko; Keiichirou Morimura; Anna Kakehashi; Hideki Wanibuchi; Alexander Vozianov; Shoji Fukushima
Aberrant expression of E-cadherin and beta-catenin in association with transforming growth factor-beta1 in urinary bladder lesions in humans after the Chernobyl accident.
Cancer science 2006;97(1):45-50.
2005: Masahiko Kushida; Hideki Wanibuchi; Keiichirou Morimura; Anna Kakehashi; Jin Seok Kang; Rawiwan Puatanachokchai; Min Wei; Yoshihiko Funae; Shoji Fukushima
Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold.
Cancer science 2005;96(11):747-57.
2005: Shoji Fukushima; Anna Kakehashi; Rawiwan Puatanachokchai; Masahiko Kushida; Hideki Wanibuchi; Keiichirou Morimura
Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens.
Carcinogenesis 2005;26(11):1835-45.
2005: Masahiko Kushida; Tokuo Sukata; Satoshi Uwagawa; Keisuke Ozaki; Anna Kakehashi; Hideki Wanibuchi; Keiichirou Morimura; Yasuyoshi Okuno; Shoji Fukushima
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms.
Toxicology and applied pharmacology 2005;208(3):285-94.
2005: Takashi Murai; Yukio Mori; Kenjiro Tatematsu; Akihiro Koide; Akihiro Hagiwara; Susumu Makino; Satoru Mori; Hideki Wanibuchi; Shoji Fukushima
Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis.
Cancer science 2005;96(10):637-44.
2005: Shoji Fukushima; Keiichirou Morimura; Hideki Wanibuchi; Anna Kakehashi; Elsayed I. Salim
Current and emerging challenges in toxicopathology: carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens.
Toxicology and applied pharmacology 2005;207(2 Suppl):225-9.
2005: Kenichiro Doi; Hideki Wanibuchi; Elsayed I. Salim; Keiichirou Morimura; Anna Kakehashi; Shinzoh Kudoh; Kazuto Hirata; Junichi Yoshikawa; Shoji Fukushima
Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethane.
International journal of cancer. Journal international du cancer 2005;115(6):870-8.
2005: Shoji Fukushima; Hideki Wanibuchi; Keiichirou Morimura; Dai Nakae; Hiroyuki Tsuda; Katsumi Imaida; Tomoyuki Shirai; Masae Tatematsu; Tetsuya Tsukamoto; Masao Hirose; Fumio Furukawa
Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver.
Cancer letters 2005;222(1):11-5.
2005: Jin Seok Kang; Hideki Wanibuchi; Keiichirou Morimura; Rawiwan Puatanachokchai; Elsayed I. Salim; Atsushi Hagihara; Shuichi Seki; Shoji Fukushima
Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):720-6.
2005: Min Wei; Keiichirou Morimura; Hideki Wanibuchi; Jun Shen; Elsayed I. Salim; Masaharu Moku; Katsuo Hakoi; Shoji Fukushima
JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats.
International journal of cancer. Journal international du cancer 2005;113(3):354-8.
2005: Keiichirou Morimura; Jin Seok Kang; Min Wei; Hideki Wanibuchi; Hiroyuki Tsuda; Shoji Fukushima
Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats.
Toxicologic pathology 2005;33(7):764-7.
2005: Jin Seok Kang; Keiichirou Morimura; Elsayed I. Salim; Hideki Wanibuchi; Shuji Yamaguchi; Shoji Fukushima
Persistence of liver cirrhosis in association with proliferation of nonparenchymal cells and altered location of alpha-smooth muscle actin-positive cells.
Toxicologic pathology 2005;33(3):329-35.
2004: Toshio Ichihara; Hideki Wanibuchi; Yukari Totsuka; Keiichirou Morimura; Min Wei; Dai Nakae; Shoji Fukushima
Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats.
Cancer science 2004;95(12):943-8.
2004: Yushi Fujiwara; Harushi Osugi; Keiichirou Morimura; Masashi Takemura; Shigeru Lee; Kazuhiro Hirohashi; Shoji Fukushima; Shigefumi Suehiro
Suppressive effect of CPT-11 on rat esophageal tumorigenesis induced by N-nitrosomethylbenzylamine.
Oncology reports 2004;12(6):1169-76.
2004: Elsayed I. Salim; Masahiro Kaneko; Hideki Wanibuchi; Keiichirou Morimura; Shoji Fukushima
Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(12):1949-69.
2004: Tokuo Sukata; Satoshi Uwagawa; Keisuke Ozaki; Kayo Sumida; Kaoru Kikuchi; Masahiko Kushida; Koichi Saito; Keiichirou Morimura; Kenji Oeda; Yasuyoshi Okuno; Nobuyoshi Mikami; Shoji Fukushima
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
The American journal of pathology 2004;165(5):1479-88.
2004: Manabu Hoshi; Keiichirou Morimura; Hideki Wanibuchi; Min Wei; Eriko Okochi; Toshikazu Ushijima; Kunio Takaoka; Shoji Fukushima
No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(2):273-9.
2004: Kenichiro Fukuhara; Harushi Osugi; Nobuyasu Takada; Masashi Takemura; Shigeru Lee; Keiichirou Morimura; Shinichi Taguchi; Masahiro Kaneko; Yoshinori Tanaka; Yushi Fujiwara; Satoshi Nishizawa; Shoji Fukushima; Hiroaki Kinoshita
Effect of H. pylori on COX-2 expression in gastric remnant after distal gastrectomy.
Hepato-gastroenterology 2004;51(59):1515-8.
2004: Hideki Wanibuchi; Elsayed I. Salim; Anna Kakehashi; Jun Shen; Min Wei; Keiichirou Morimura; Kaoru Yoshida; Koichi Kuroda; Ginji Endo; Shoji Fukushima
Understanding arsenic carcinogenicity by the use of animal models.
Toxicology and applied pharmacology 2004;198(3):366-76.
2004: Koichi Kuroda; Kaoru Yoshida; Mieko Yoshimura; Yoko Endo; Hideki Wanibuchi; Shoji Fukushima; Ginji Endo
Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic.
Toxicology and applied pharmacology 2004;198(3):345-53.
2004: Jun Shen; Hideki Wanibuchi; Elsayed I. Salim; Min Wei; Takesuke Yamachika; Shoji Fukushima
Inhibition of azoxymethane-induced colon carcinogenesis in rats due to JTE-522, a selective cyclooxygenase-2 inhibitor.
Asian Pacific journal of cancer prevention : APJCP 2004;5(3):253-8.
2004: Shoji Fukushima; Hideki Wanibuchi; Keiichirou Morimura; Shuji Iwai; Dai Nakae; Hideki Kishida; Hiroyuki Tsuda; N Uehara; Katsumi Imaida; Tomoyuki Shirai; Masae Tatematsu; Tetsuya Tsukamoto; Masao Hirose; Fumio Furukawa
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(1):109-14.
2004: Yoshinori Tanaka; Harushi Osugi; Keiichirou Morimura; Masashi Takemura; Masakatsu Ueno; Masahiro Kaneko; Shoji Fukushima; Hiroaki Kinoshita
Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils.
Oncology reports 2004;11(5):965-71.
2004: Keiichirou Morimura; Alina Romanenko; Wei Min; Elsayed I. Salim; Anna Kakehashi; Hideki Wanibuchi; Alexander Vozianov; Shoji Fukushima
Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster.
Oncology reports 2004;11(4):881-6.
2004: Kenichiro Doi; Hideki Wanibuchi; Elsayed I. Salim; Jun Shen; Min Wei; Makoto Mitsuhashi; Shinzoh Kudoh; Kazuto Hirata; Shoji Fukushima
Revised rat multi-organ carcinogenesis bioassay for whole-body detection of chemopreventive agents: modifying potential of S-methylcysteine.
Cancer letters 2004;206(1):15-26.
2004: Min Wei; Hideki Wanibuchi; Keiichirou Morimura; Elsayed I. Salim; Masaharu Moku; Kenichiro Doi; Makoto Mitsuhashi; Chikayoshi Masuda; Jun Shen; Anna Kakehashi; Shoji Fukushima
Lack of preventive efficacy of FK228, a histone deacetylase inhibitor, against N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in p53+/- and p53+/+ mice.
Anticancer research 2004;24(2B):785-90.
2004: Masako Okina; Kaoru Yoshida; Koichi Kuroda; Hideki Wanibuchi; Shoji Fukushima; Ginji Endo
Determination of trivalent methylated arsenicals in rat urine by liquid chromatography-inductively coupled plasma mass spectrometry after solvent extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;799(2):209-15.
2004: Toru Mukohara; Shinzoh Kudoh; Kuniomi Matsuura; Setsuko Yamauchi; Tatsuo Kimura; Naruo Yoshimura; Hiroshi Kanazawa; Kazuto Hirata; Kiyotoshi Inoue; Hideki Wanibuchi; Shoji Fukushima; Junichi Yoshikawa
Activated Akt expression has significant correlation with EGFR and TGF-alpha expressions in stage I NSCLC.
Anticancer research 2004;24(1):11-7.
2003: Jun Shen; Hideki Wanibuchi; Elsayed I. Salim; Min Wei; Kenichiro Doi; Kaoru Yoshida; Ginji Endo; Keiichirou Morimura; Shoji Fukushima
Induction of glutathione S-transferase placental form positive foci in liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks.
Toxicology and applied pharmacology 2003;193(3):335-45.
2003: Min Wei; Keiichirou Morimura; Hideki Wanibuchi; Jun Shen; Kenichiro Doi; Makoto Mitsuhashi; Masaharu Moku; Elsayed I. Salim; Shoji Fukushima
Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis.
Cancer letters 2003;202(1):11-6.
2003: Makoto Mitsuhashi; Hideki Wanibuchi; Keiichirou Morimura; Ken'ichiro Doi; Min Wei; Seiji Wada; Tatsuya Nakatani; Shoji Fukushima
Significance of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Cancer science 2003;94(12):1052-8.
2003: Jun Shen; Hideki Wanibuchi; Elsayed I. Salim; Min Wei; Anna Kakehashi; Kaoru Yoshida; Ginji Endo; Shoji Fukushima
Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats--association with oxidative DNA damage and enhanced cell proliferation.
Carcinogenesis 2003;24(11):1827-35.
2003: Kaoru Yoshida; Koichi Kuroda; Xu Zhou; Yoshinori Inoue; Yukiko Date; Hideki Wanibuchi; Shoji Fukushima; Ginji Endo
Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats.
Chemical research in toxicology 2003;16(9):1124-9.
2003: Toru Mukohara; Shinzoh Kudoh; Setsuko Yamauchi; Tatsuo Kimura; Naruo Yoshimura; Hiroshi Kanazawa; Kazuto Hirata; Hideki Wanibuchi; Shoji Fukushima; Kiyotoshi Inoue; Junichi Yoshikawa
Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC).
Lung cancer (Amsterdam, Netherlands) 2003;41(2):123-30.
2003: Anna Kakehashi; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Jun Shen; Susumu Imaoka; Yoshihiko Funae; Shoji Fukushima
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.
Carcinogenesis 2003;24(8):1389-99.
2003: Motome Ogawa; Hideki Wanibuchi; Takayuki Nishkawa; Yoshihisa Yano; Shuzo Otani; Yukari Totsuka; Keiji Wakabayashi; Dai Nakae; Shoji Fukushima
Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
Osaka city medical journal 2003;49(1):21-30.
2003: Takayuki Nishikawa; Elsayed I. Salim; Keiichirou Morimura; Masahiro Kaneko; Motome Ogawa; Anna Kakehashi; Harushi Osugi; Hiroaki Kinoshita; Shoji Fukushima
High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine.
Cancer letters 2003;194(1):45-54.
2003: Alina Romanenko; Keiichirou Morimura; Hideki Wanibuchi; Min Wei; Wadim K Zaparin; Wladimir I Vinnichenko; Anna Kakehashi; Alexander Vozianov; Shoji Fukushima
Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation.
Cancer science 2003;94(4):328-33.
2003: M Rezaul Karim; Hideki Wanibuchi; Min Wei; Keiichirou Morimura; Elsayed I. Salim; Shoji Fukushima
Enhancing risk of ethanol on MeIQx-induced rat hepatocarcinogenesis is accompanied with increased levels of cellular proliferation and oxidative stress.
Cancer letters 2003;192(1):37-47.
2003: Noritaka Seike; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Takayuki Nishikawa; Kazuto Hirata; Junichi Yoshikawa; Shoji Fukushima
Enhancement of lung carcinogenesis by nonylphenol and genistein in a F344 rat multiorgan carcinogenesis model.
Cancer letters 2003;192(1):25-36.
2003: Shoji Fukushima; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Dai Nakae; Yoichi Konishi; Hiroyuki Tsuda; Nobuo Takasuka; Katsumi Imaida; Tomoyuki Shirai; Masae Tatematsu; Tetsuya Tsukamoto; Masao Hirose; Fumio Furukawa
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Cancer letters 2003;191(1):35-40.
2003: Elsayed I. Salim; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Makoto Mitsuhashi; Kaoru Yoshida; Ginji Endo; Shoji Fukushima
Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice.
Carcinogenesis 2003;24(2):335-42.
2003: Shoji Fukushima; Malcolm A Moore; Hiroyuki Tsuda
Appropriate models and an understanding of carcinogenic mechanisms--requirements for hazard risk assessment.
Asian Pacific journal of cancer prevention : APJCP 2003;4(1):75-8.
2003: Makoto Mitsuhashi; Hideki Wanibuchi; Min Wei; Ken'ichro Doi; Keiichirou Morimura; Chikayoshi Masuda; Seiji Wada; Tatsuya Nakatani; Tadao Kakizoe; Shoji Fukushima
No inhibition of urinary bladder carcinogenesis in rats with intravesical instillation of alpha-galactosylceramide.
Asian Pacific journal of cancer prevention : APJCP 2003;4(1):45-50.
2002: Shoji Fukushima; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Dai Nakae; Yoichi Konishi; Hiroyuki Tsuda; Nobuaki Uehara; Katsumi Imaida; Tomoyuki Shirai; Masae Tatematsu; Tetsuya Tsukamoto; Masao Hirose; Fumio Furukawa; Keiji Wakabayashi; Yukari Totsuka
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.
Japanese journal of cancer research : Gann 2002;93(10):1076-82.
2002: Masahiro Kaneko; Keiichirou Morimura; Takayuki Nishikawa; Hideki Wanibuchi; Nobuyasu Takada; Harushi Osugi; Hiroaki Kinoshita; Shoji Fukushima
Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens.
Carcinogenesis 2002;23(10):1729-35.
2002: Elsayed I. Salim; Hideki Wanibuchi; Keiichirou Morimura; Takashi Murai; Susumu Makino; Taisei Nomura; Shoji Fukushima
Induction of tumors in the colon and liver of the immunodeficient (SCID) mouse by 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ)-modulation by long-chain fatty acids.
Carcinogenesis 2002;23(9):1519-29.
2002: Alina Romanenko; Keiichirou Morimura; Min Wei; Wadim K Zaparin; Alexander Vozianov; Shoji Fukushima
DNA damage repair in bladder urothelium after the Chernobyl accident in Ukraine.
The Journal of urology 2002;168(3):973-7.
2002: Min Wei; Hideki Wanibuchi; Keiichirou Morimura; Shuji Iwai; Kaoru Yoshida; Ginji Endo; Dai Nakae; Shoji Fukushima
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.
Carcinogenesis 2002;23(8):1387-97.
2002: Takayuki Nishikawa; Hideki Wanibuchi; Motome Ogawa; Anna Kakehashi; Keiichirou Morimura; Toyoko Hiroi; Yoshihiko Funae; Hideki Kishida; Dai Nakae; Shoji Fukushima
Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism.
International journal of cancer. Journal international du cancer 2002;100(2):136-9.
2002: Shuji Iwai; Rezaul Karim; Mitsuaki Kitano; Tokuo Sukata; Wei Min; Keiichirou Morimura; Hideki Wanibuchi; Shuichi Seki; Shoji Fukushima
Role of oxidative DNA damage caused by carbon tetrachloride-induced liver injury -- enhancement of MeIQ-induced glutathione S-transferase placental form-positive foci in rats.
Cancer letters 2002;179(1):15-24.
2002: Yukio Mori; Akihiro Koide; Yoshinori Kobayashi; Keiichirou Morimura; Masahiro Kaneko; Shoji Fukushima
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.
Mutagenesis 2002;17(3):251-6.
2002: Tokuo Sukata; Satoshi Uwagawa; Keisuke Ozaki; Motome Ogawa; Takayuki Nishikawa; Syuji Iwai; Anna Kakehashi; Hideki Wanibuchi; Susumu Imaoka; Yoshihiko Funae; Yasuyoshi Okuno; Shoji Fukushima
Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effect.
International journal of cancer. Journal international du cancer 2002;99(1):112-8.
2002: Masakazu Kakuni; Keiichirou Morimura; Hideki Wanibuchi; Motome Ogawa; Wei Min; Shuji Hayashi; Shoji Fukushima
Food restriction inhibits the growth of intestinal polyps in multiple intestinal neoplasia mouse.
Japanese journal of cancer research : Gann 2002;93(3):236-41.
2002: Anna Kakehashi; Hideki Wanibuchi; Susumu Imaoka; Motome Ogawa; Chikayoshi Masuda; Keiichirou Morimura; Yoshihiko Funae; Shoji Fukushima
Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.
Carcinogenesis 2002;23(2):341-9.
2002: Noritaka Seike; Hideki Wanibuchi; Keiichirou Morimura; Takayuki Nishikawa; Hideki Kishida; Dai Nakae; Kazuto Hirata; Shoji Fukushima
Lack of promoting effect due to oral administration of dimethylarsinic acid on rat lung carcinogenesis initiated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer letters 2002;175(2):113-9.
2002: Rezaul Karim; Shuji Iwai; Keiichirou Morimura; Hideki Wanibuchi; Reiko Tanaka; Shunyo Matsunaga; Akira Yoshitake; Shoji Fukushima
Lack of modification of rat hepatocarcinogenesis by fernane-type triterpenoids, isolated from a Euphorbia genus.
Teratogenesis, carcinogenesis, and mutagenesis 2002;22(4):293-9.
2001: H Gen; Shigeo Yamamoto; Keiichirou Morimura; Wei Min; Makoto Mitsuhashi; Takashi Murai; Satoru Mori; M Hosono; T Oohara; Susumu Makino; Hideki Wanibuchi; Shoji Fukushima
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
Japanese journal of cancer research : Gann 2001;92(12):1278-83.
2001: Shoji Fukushima; Hideki Wanibuchi; W Li
Inhibition by ginseng of colon carcinogenesis in rats.
Journal of Korean medical science 2001;16 Suppl():S75-80.
2001: Yukio Mori; Akihiro Koide; K Fuwa; Hideki Wanibuchi; Shoji Fukushima
Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53+/- knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Mutagenesis 2001;16(5):377-83.
2001: Shoji Fukushima
Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
Mutation research 2001;477(1-2):125-30.
2001: M Vijayaraghavan; Hideki Wanibuchi; Rezaul Karim; Shigeo Yamamoto; Chikayoshi Masuda; Dai Nakae; Yoichi Konishi; Shoji Fukushima
Dimethylarsinic acid induces 8-hydroxy-2'-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats.
Cancer letters 2001;165(1):11-7.
2001: Shoji Fukushima; Nobuyasu Takada; Hideki Wanibuchi; Taka-Aki Hori; Wei Min; Motome Ogawa
Suppression of chemical carcinogenesis by water-soluble organosulfur compounds.
The Journal of nutrition 2001;131(3s):1049S-53S.
2001: Chikayoshi Masuda; Hideki Wanibuchi; K Otori; Min Wei; Shigeo Yamamoto; Toyoko Hiroi; Susumu Imaoka; Yoshihiko Funae; Shoji Fukushima
Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats.
Cancer letters 2001;163(2):179-85.
2001: Keiichirou Morimura; T Hori; Masahiro Kaneko; Takayuki Nishikawa; A Nishikawa; Hideki Wanibuchi; Nobuyasu Takada; Harushi Osugi; Shoji Fukushima
Promotion of chemically induced rat esophageal tumorigenesis with post-initiation ethanol modification.
Teratogenesis, carcinogenesis, and mutagenesis 2001;21(4):295-301.
2001: Ikko Higaki; Kazuhiro Hirohashi; Shoji Fukushima; Hideki Wanibuchi; Noritaka Seike; T Yamane; Shoji Kubo; Hiromu Tanaka; Taichi Shuto; Takatsugu Yamamoto; Hiroaki Kinoshita
Renal pelvic carcinoma producing granulocyte colony-stimulating factor: report of a case.
Surgery today 2001;31(3):266-8.
2001: Shuji Iwai; Min Wei; Keiichirou Morimura; Hideki Wanibuchi; R Tanaka; Shunyo Matsunaga; A Yoshitake; Shuichi Seki; Shoji Fukushima
Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver.
Teratogenesis, carcinogenesis, and mutagenesis 2001;21(3):223-9.
2000: Min Wei; Hideki Wanibuchi; Shigeo Yamamoto; Shuji Iwai; Keiichirou Morimura; Taisei Nomura; R Takayama; Shoji Fukushima
Chemopreventive effects of S-methylcysteine on rat hepatocarcinogenesis induced by concurrent administration of sodium nitrite and morpholine.
Cancer letters 2000;161(1):97-103.
2000: M Vijayaraghavan; Hideki Wanibuchi; Nobuyasu Takada; Yoshihisa Yano; Shuzo Otani; Shigeo Yamamoto; Shoji Fukushima
Inhibitory effects of S-methylcysteine and cysteine on the promoting potential of sodium phenobarbital on rat liver carcinogenesis.
Japanese journal of cancer research : Gann 2000;91(8):780-5.
2000: Mitsuaki Kitano; Hideki Wanibuchi; Hiroe Kikuzaki; Nobuji Nakatani; Susumu Imaoka; Yoshihiko Funae; Shuji Hayashi; Shoji Fukushima
Chemopreventive effects of coumaperine from pepper on the initiation stage of chemical hepatocarcinogenesis in the rat.
Japanese journal of cancer research : Gann 2000;91(7):674-80.
2000: Alina Romanenko; Keiichirou Morimura; Hideki Wanibuchi; Elsayed I. Salim; Anna Kakehashi; M Kaneko; Alexander Vozianov; Shoji Fukushima
Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident.
International journal of cancer. Journal international du cancer 2000;86(6):790-8.
2000: Chikayoshi Masuda; Hideki Wanibuchi; K Sekine; Yoshihisa Yano; Shuzo Otani; Taketoshi Kishimoto; Hiroyuki Tsuda; Shoji Fukushima
Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis.
Japanese journal of cancer research : Gann 2000;91(6):582-8.
2000: T Morikawa; Hideki Wanibuchi; Keiichirou Morimura; Motome Ogawa; Shoji Fukushima
Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice.
Japanese journal of cancer research : Gann 2000;91(6):579-81.
2000: H Ohtani; Masakazu Yashiro; Naoyoshi Onoda; Nobuaki Nishioka; Yasuyuki Kato; S Yamamoto; Shoji Fukushima; Kosei Hirakawa-YS Chung
Synchronous multiple primary gastrointestinal cancer exhibits frequent microsatellite instability.
International journal of cancer. Journal international du cancer 2000;86(5):678-83.
2000: Shigeo Yamamoto; M Tada; Chyi-Chia Richard Lee; Chikayoshi Masuda; Hideki Wanibuchi; R Yoshimura; S Wada; K Yamamoto; Taketoshi Kishimoto; Shoji Fukushima
p53 status in multiple human urothelial cancers: assessment for clonality by the yeast p53 functional assay in combination with p53 immunohistochemistry.
Japanese journal of cancer research : Gann 2000;91(2):181-9.
2000: Elsayed I. Salim; Hideki Wanibuchi; Keiichirou Morimura; S Kim; Yoshihisa Yano; Shigeo Yamamoto; Shoji Fukushima
Inhibitory effects of 1,3-diaminopropane, an ornithine decarboxylase inhibitor, on rat two-stage urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis 2000;21(2):195-203.
2000: T Taniyama; Hideki Wanibuchi; Elsayed I. Salim; Yoshihisa Yano; Shuzo Otani; Yoshiki Nishizawa; Hirotoshi Morii; Shoji Fukushima
Chemopreventive effect of 24R,25-dihydroxyvitamin D(3) in N, N'-dimethylhydrazine-induced rat colon carcinogenesis.
Carcinogenesis 2000;21(2):173-8.
2000: Takashi Murai; Satoru Mori; M Hosono; Y Iwakura; A Takashima; T Oohara; Susumu Makino; R Takeda; Shoji Fukushima
Induction of hepatocellular carcinoma with high metastatic potential in WS/Shi rats: discovery of an inbred strain highly susceptible to the liver carcinogen N-nitrosomorpholine.
Oncology research 2000;12(3):121-6.
2000: W Li; Hideki Wanibuchi; Elsayed I. Salim; Min Wei; Shigeo Yamamoto; H Nishino; Shoji Fukushima
Inhibition by ginseng of 1,2-dimethylhydrazine induction of aberrant crypt foci in the rat colon.
Nutrition and cancer 2000;36(1):66-73.
2000: Tokuo Sukata; Keisuke Ozaki; Satoshi Uwagawa; Takaki Seki; Hideki Wanibuchi; Shigeo Yamamoto; Yasuyoshi Okuno; Shoji Fukushima
Organ-specific, carcinogen-induced increases in cell proliferation in p53-deficient mice.
Cancer research 2000;60(1):74-9.
1999: TX Chen; Hideki Wanibuchi; Min Wei; Keiichirou Morimura; Shigeo Yamamoto; Shuji Hayashi; Shoji Fukushima
Concentration dependent promoting effects of sodium L-ascorbate with the same total dose in a rat two-stage urinary bladder carcinogenesis.
Cancer letters 1999;146(1):67-71.
1999: Shoji Fukushima
Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment.
Cancer letters 1999;143(2):157-9.
1999: Min Wei; Hideki Wanibuchi; Shigeo Yamamoto; W Li; Shoji Fukushima
Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats.
Carcinogenesis 1999;20(9):1873-6.
1999: Chyi-Chia Richard Lee; Toshio Ichihara; Shigeo Yamamoto; Hideki Wanibuchi; K Sugimura; Seiji Wada; Taketoshi Kishimoto; Shoji Fukushima
Reduced expression of the CDK inhibitor p27(KIP1) in rat two-stage bladder carcinogenesis and its association with expression profiles of p21(WAF1/Cip1) and p53.
Carcinogenesis 1999;20(9):1697-708.
1999: T Chen; Y Na; Hideki Wanibuchi; Shigeo Yamamoto; Chyi-Chia Richard Lee; Shoji Fukushima
Loss of heterozygosity in (LewisxF344)F1 rat urinary bladder tumors induced with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by dimethylarsinic acid or sodium L-ascorbate.
Japanese journal of cancer research : Gann 1999;90(8):818-23.
1999: Shigeo Yamamoto; Alina Romanenko; Min Wei; Chikayoshi Masuda; Wadim K Zaparin; Wladimir I Vinnichenko; Alexander Vozianov; Chyi-Chia Richard Lee; Keiichirou Morimura; Hideki Wanibuchi; M Tada; Shoji Fukushima
Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident.
Cancer research 1999;59(15):3606-9.
1999: Chyi-Chia Richard Lee; Hideki Wanibuchi; S Yamamoto; M Hirose; Y Hayashi; Shoji Fukushima
Molecular cytogenetic identification of cyclin D1 gene amplification in a renal pelvic tumor attributed to phenacetin abuse.
Pathology international 1999;49(7):648-52.
1999: Toshio Ichihara; Hideki Wanibuchi; T Taniyama; Y Okai; Yoshihisa Yano; Shuzo Otani; Susumu Imaoka; Yoshihiko Funae; Shoji Fukushima
Inhibition of liver glutathione S-transferase placental form-positive foci development in the rat hepatocarcinogenesis by Porphyra tenera (Asakusa-nori).
Cancer letters 1999;141(1-2):211-8.
1999: E M Youssef; Hideki Wanibuchi; Satoru Mori; Elsayed I. Salim; Shuji Hayashi; Shoji Fukushima
Elevation of urinary enzyme levels in rat bladder carcinogenesis.
Carcinogenesis 1999;20(7):1247-52.
1999: K Otori; Chikayoshi Masuda; Hideki Wanibuchi; A Nakanishi; K Kawabata; Hirotsugu Ohashi; Shoji Fukushima
An autopsy report of graft-versus-host disease (GVHD) following blood transfusion.
Osaka city medical journal 1999;45(1):37-43.
1999: Keiichirou Morimura; Elsayed I. Salim; Shigeo Yamamoto; Hideki Wanibuchi; Shoji Fukushima
Dose-dependent induction of aberrant crypt foci in the colons but no neoplastic lesions in the livers of heterozygous p53-deficient mice treated with low dose 2-amino-3-methylimidazo [4,5-f]quinoline.
Cancer letters 1999;138(1-2):81-5.
1999: Keiichirou Morimura; Shigeo Yamamoto; Takashi Murai; Satoru Mori; TX Chen; Hideki Wanibuchi; Shoji Fukushima
LOH and mutational analysis of p53 alleles in mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.
Carcinogenesis 1999;20(4):715-8.
1999: Alina Romanenko; Chyi-Chia Richard Lee; Shigeo Yamamoto; T Hori; Hideki Wanibuchi; Wadim K Zaparin; Wladimir I Vinnichenko; Alexander Vozianov; Shoji Fukushima
Urinary bladder lesions after the Chernobyl accident: immunohistochemical assessment of p53, proliferating cell nuclear antigen, cyclin D1 and p21WAF1/Cip1.
Japanese journal of cancer research : Gann 1999;90(2):144-53.
1999: Toshio Ichihara; Hideki Wanibuchi; Chyi-Chia Richard Lee; K Nakajima; Yoshihisa Yano; T Taniyama; Shuzo Otani; Y Shimizu; Shoji Fukushima
Lack of inhibitory effects of the Ju-myo protein on development of glutathione S-transferase placental form-positive foci in the male F344 rat liver.
The Journal of toxicological sciences 1999;24(1):27-31.
1999: Shigeo Yamamoto; Wei Min; Chyi-Chia Richard Lee; Elsayed I. Salim; Hideki Wanibuchi; Tokuo Sukata; Shoji Fukushima
Enhancement of urinary bladder carcinogenesis in nullizygous p53-deficient mice by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Cancer letters 1999;135(2):137-44.
1999: Elsayed I. Salim; Hideki Wanibuchi; Shigeo Yamamoto; K Morimura; S Mori; S Makino; T Nomura; Shoji Fukushima
Low-dose-dependent carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline in the immunodeficient (SCID) mouse colon.
Nutrition and cancer 1999;34(2):220-8.
1999: Shoji Fukushima; T Murai
Calculi, precipitates and microcrystalluria associated with irritation and cell proliferation as a mechanism of urinary bladder carcinogenesis in rats and mice.
IARC scientific publications 1999;(147):159-74.
1999: TX Chen; Hideki Wanibuchi; Takashi Murai; Mitsuaki Kitano; Shigeo Yamamoto; Shoji Fukushima
Promotion by sodium L-ascorbate in rat two-stage urinary bladder carcinogenesis is dependent on the interval of administration.
Japanese journal of cancer research : Gann 1999;90(1):16-22.
1998: W Li; Hideki Wanibuchi; Elsayed I. Salim; Shigeo Yamamoto; Kaoru Yoshida; Ginji Endo; Shoji Fukushima
Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound.
Cancer letters 1998;134(1):29-36.
1998: Keisuke Ozaki; Tokuo Sukata; Shigeo Yamamoto; Satoshi Uwagawa; Takaki Seki; H Kawasaki; A Yoshitake; Hideki Wanibuchi; A Koide; Y Mori; Shoji Fukushima
High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.
Cancer research 1998;58(17):3806-11.
1998: Mitsuaki Kitano; Toshio Ichihara; T Matsuda; Hideki Wanibuchi; S Tamano; A Hagiwara; Susumu Imaoka; Yoshihiko Funae; Tomoyuki Shirai; Shoji Fukushima
Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.
Carcinogenesis 1998;19(8):1475-80.
1998: Kaoru Yoshida; Yoshinori Inoue; Koichi Kuroda; H Chen; Hideki Wanibuchi; Shoji Fukushima; Ginji Endo
Urinary excretion of arsenic metabolites after long-term oral administration of various arsenic compounds to rats.
Journal of toxicology and environmental health. Part A 1998;54(3):179-92.
1998: C C Lee; Shoji Fukushima
Review article Alterations in cyclin D1, p53, and the cell cycle related elements Implications for distinct genetic pathways of urinary bladder carcinogenesis.
Urologic oncology 1998;4(3):58-72.
1998: Shigeo Yamamoto; Masae Tatematsu; M Yamamoto; H Fukami; Shoji Fukushima
Clonal analysis of urothelial carcinomas in C3H/HeN<-->BALB/c chimeric mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis 1998;19(5):855-60.
1998: Nobuyasu Takada; Yoshihisa Yano; K Otori; Shuzo Otani; S Nomura; Y Kitamura; Shoji Fukushima
Expression and localization of ornithine decarboxylase in reversible papillomatosis induced by uracil in rat bladder.
Japanese journal of cancer research : Gann 1998;89(4):377-84.
1998: Taka-Aki Hori; Hideki Wanibuchi; Yoshihisa Yano; Shuzo Otani; A Nishikawa; Harushi Osugi; Hiroaki Kinoshita; Shoji Fukushima
Epithelial cell proliferation in the digestive tract induced by space restriction and water-immersion stress.
Cancer letters 1998;125(1-2):141-8.
1998: Chyi-Chia Richard Lee; Chikayoshi Masuda; S Yamamoto; Hideki Wanibuchi; Shinichi Ikemoto; K Sugimura; T Nakatani; S Wada; T Kishimoto; Shoji Fukushima
Assessment of cell cycle-related elements p53, p21WAF1/Cip1, cyclin D1 and PCNA in a mixed transitional cell carcinoma and adenocarcinoma of the renal pelvis: a case report.
Japanese journal of clinical oncology 1998;28(3):227-32.
1998: T Chen; Shigeo Yamamoto; H Gen; Takashi Murai; Satoru Mori; T Oohara; Susumu Makino; Hideki Wanibuchi; Shoji Fukushima
Infrequent involvement of microsatellite instability in urinary bladder carcinomas of the NON/Shi mouse treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Cancer letters 1998;123(1):41-5.
1998: T Chen; Shigeo Yamamoto; Mitsuaki Kitano; Takashi Murai; Hideki Wanibuchi; S Matsukuma; Yoko Nakatsuru; T Ishikawa; Shoji Fukushima
Possible rare involvement of O6-methylguanine formation as a significant mutational factor in mouse urinary bladder carcinogenesis models.
Teratogenesis, carcinogenesis, and mutagenesis 1998;18(3):101-10.
1998: Satoru Mori; Takashi Murai; M Hosono; H Yamashita; T Oohara; Susumu Makino; M Doteuchi; Shoji Fukushima
F344/Shi rats bearing type b catalase-1 locus are sensitive to sodium L-ascorbate promotion of two-stage urinary bladder carcinogenesis.
Teratogenesis, carcinogenesis, and mutagenesis 1998;18(1):27-33.
1998: A Shigesawa; Naoyoshi Onoda; Y S Chung; Yoshihisa Yano; Shuzo Otani; Shoji Fukushima; Michio Sowa
Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.
Oncology reports 1998;5(1):125-9.
1997: Hideki Wanibuchi; Taka-Aki Hori; V Meenakshi; Toshio Ichihara; Shigeo Yamamoto; Yoshihisa Yano; Shuzo Otani; Dai Nakae; Yoichi Konishi; Shoji Fukushima
Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: association with elevated ornithine decarboxylase activity and formation of 8-hydroxydeoxyguanosine in the liver.
Japanese journal of cancer research : Gann 1997;88(12):1149-54.
1997: Elsayed I. Salim; Hideki Wanibuchi; T Taniyama; Yoshihisa Yano; Keiichirou Morimura; Shigeo Yamamoto; Shuzo Otani; Yoshiki Nishizawa; Hirotoshi Morii; Shoji Fukushima
Inhibition of development of N,N'-dimethylhydrazine-induced rat colonic aberrant crypt foci by pre, post and simultaneous treatments with 24R,25-dihydroxyvitamin D3.
Japanese journal of cancer research : Gann 1997;88(11):1052-62.
1997: Chyi-Chia Richard Lee; Shigeo Yamamoto; Hideki Wanibuchi; Seiji Wada; K Sugimura; Taketoshi Kishimoto; Shoji Fukushima
Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation.
Cancer research 1997;57(21):4765-76.
1997: Shigeo Yamamoto; T Chen; Takashi Murai; Satoru Mori; Keiichirou Morimura; T Oohara; Susumu Makino; Masae Tatematsu; Hideki Wanibuchi; Shoji Fukushima
Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis 1997;18(10):1877-82.
1997: Mitsuaki Kitano; Nobuyasu Takada; T Chen; H Ito; Taisei Nomura; Hiroyuki Tsuda; C P Wild; Shoji Fukushima
Carcinogenicity of methylurea or morpholine in combination with sodium nitrite in rat multi-organ carcinogenesis bioassay.
Japanese journal of cancer research : Gann 1997;88(9):797-806.
1997: Satoru Mori; Takashi Murai; M Hosono; S Machino; Susumu Makino; C Chou; Shoji Fukushima
Lack of promotion of urinary bladder carcinogenesis by sodium bicarbonate and/or L-ascorbic acid in male ODS/Shi-od/od rats synthesizing alpha 2 mu-globulin but not L-ascorbic acid.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(8):783-7.
1997: K Otori; Yoshihisa Yano; Nobuyasu Takada; Chyi-Chia Richard Lee; Shuji Hayashi; Shuzo Otani; Shoji Fukushima
Reversibility and apoptosis in rat urinary bladder papillomatosis induced by uracil.
Carcinogenesis 1997;18(8):1485-9.
1997: Shigeo Yamamoto; Hideki Wanibuchi; Taka-Aki Hori; Yoshihisa Yano; Isao Matsui-Yuasa; Shuzo Otani; H Chen; Kaoru Yoshida; Koichi Kuroda; Ginji Endo; Shoji Fukushima
Possible carcinogenic potential of dimethylarsinic acid as assessed in rat in vivo models: a review.
Mutation research 1997;386(3):353-61.
1997: Nobuyasu Takada; Yoshihisa Yano; Hideki Wanibuchi; Shuzo Otani; Shoji Fukushima
S-methylcysteine and cysteine are inhibitors of induction of glutathione S-transferase placental form-positive foci during initiation and promotion phases of rat hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1997;88(5):435-42.
1997: H Iwata; Shigeo Yamamoto; Yoshihisa Yano; S Ohtani; Shoji Fukushima
Dose-dependent amplification by L-ascorbic acid of NaHCO3 promotion of rat urinary bladder carcinogenesis.
Toxicologic pathology 1997;25(3):284-90.
1997: Kaoru Yoshida; H Chen; Yoshinori Inoue; Hideki Wanibuchi; Shoji Fukushima; Koichi Kuroda; Ginji Endo
The urinary excretion of arsenic metabolites after a single oral administration of dimethylarsinic acid to rats.
Archives of environmental contamination and toxicology 1997;32(4):416-21.
1997: Takashi Murai; Satoru Mori; M Hosono; A Takashima; S Machino; T Oohara; H Yamashita; Susumu Makino; T Matsuda; Hideki Wanibuchi; Shoji Fukushima
Strain differences in sensitivity to the promoting effect of sodium L-ascorbate in a two-stage rat urinary bladder carcinogenesis model.
Japanese journal of cancer research : Gann 1997;88(3):245-53.
1997: Shoji Fukushima; N Takada; T Hori; Hideki Wanibuchi
Cancer prevention by organosulfur compounds from garlic and onion.
Journal of cellular biochemistry. Supplement 1997;27():100-5.
1997: E M Youssef; Tadayoshi Hasuma; Yoshihiro Morishima; Nobuyasu Takada; Harushi Osugi; M Higashino; Shuzo Otani; Shoji Fukushima
Overexpression of cyclin D1 in rat esophageal carcinogenesis model.
Japanese journal of cancer research : Gann 1997;88(1):18-25.
1996: Hideki Wanibuchi; Shigeo Yamamoto; H Chen; Kaoru Yoshida; Ginji Endo; Taka-Aki Hori; Shoji Fukushima
Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats.
Carcinogenesis 1996;17(11):2435-9.
1996: Shoji Fukushima; Y Kurata; M A Shibata
Tumours of the urinary bladder, renal pelvis, ureter and urethra.
IARC scientific publications 1996;(126):243-59.
1996: Seiji Wada; Y Kinoshita; M Kamizuru; Y Asai; H Iwata; Shinichi Ikemoto; Fumihiko Hato; Taketoshi Kishimoto; Shoji Fukushima
A study of antitumor effects of thymosin on rat and mouse urinary bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Oncology research 1996;8(3):139-44.
1995: Nobuyasu Takada; Yoshihisa Yano; T Matsuda; Shuzo Otani; Harushi Osugi; Masayuki Higashino; Hiroaki Kinoshita; Shoji Fukushima
Expression of immunoreactive human hepatocyte growth factor in human esophageal squamous cell carcinomas.
Cancer letters 1995;97(2):145-8.
1995: T Matsuda; Susumu Imaoka; Yoshihiko Funae; K Otori; Shoji Fukushima
Induction of CYP isoenzymes in various organs of rats by 3-methylcholanthrene or beta-naphthoflavone.
Cancer letters 1995;97(2):137-43.
1995: T Otoshi; H Iwata; Mitsuaki Kitano; Yoshiki Nishizawa; Hirotoshi Morii; Yoshihisa Yano; Shuzo Otani; Shoji Fukushima
Inhibition of intestinal tumor development in rat multi-organ carcinogenesis and aberrant crypt foci in rat colon carcinogenesis by 22-oxa-calcitriol, a synthetic analogue of 1 alpha, 25-dihydroxyvitamin D3.
Carcinogenesis 1995;16(9):2091-7.
1995: E M Youssef; T Matsuda; Nobuyasu Takada; Harushi Osugi; Masayuki Higashino; H Kinoshita; T Watanabe; Y Katsura; Hideki Wanibuchi; Shoji Fukushima
Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus.
Cancer 1995;76(3):358-66.
1995: Hideki Wanibuchi; H Iwata; H Washida; K Tozawa; Y Yamada; K Kang; S Hayakawa; Shoji Fukushima
A case report of inflammatory pseudotumor of the urinary bladder.
Osaka city medical journal 1995;41(1):31-9.
1995: Shigeo Yamamoto; Y Konishi; T Matsuda; Takashi Murai; M A Shibata; Isao Matsui-Yuasa; Shuzo Otani; Koichi Kuroda; Ginji Endo; Shoji Fukushima
Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens.
Cancer research 1995;55(6):1271-6.
1995: H Iwata; T Otoshi; Nobuyasu Takada; Takashi Murai; S Tamano; T Watanabe; Y Katsura; Shoji Fukushima
Validation of silver-stained nucleolar organizer regions for evaluation of invasive character of urinary bladder carcinoma in rats and mice.
Urological research 1995;23(1):27-32.
1994: T Matsuda; Nobuyasu Takada; Yoshihisa Yano; Hideki Wanibuchi; Shuzo Otani; Shoji Fukushima
Dose-dependent inhibition of glutathione S-transferase placental form-positive hepatocellular foci induction in the rat by methyl propyl disulfide and propylene sulfide from garlic and onions.
Cancer letters 1994;86(2):229-34.
1994: Nobuyasu Takada; Mitsuaki Kitano; T Chen; Yoshihisa Yano; Shuzo Otani; Shoji Fukushima
Enhancing effects of organosulfur compounds from garlic and onions on hepatocarcinogenesis in rats: association with increased cell proliferation and elevated ornithine decarboxylase activity.
Japanese journal of cancer research : Gann 1994;85(11):1067-72.
1994: T Otoshi; H Iwata; Nobuyasu Takada; Y Nishisawa; Hirotoshi Morii; Shoji Fukushima
22-Oxa-1,25(OH)2vitamin D3, a synthetic analogue of vitamin D3, has no promoting activity in a rat liver medium-term bioassay.
Cancer letters 1994;83(1-2):69-74.
1994: Nobuyasu Takada; T Matsuda; T Otoshi; Yoshihisa Yano; Shuzo Otani; T Hasegawa; D Nakae; Y Konishi; Shoji Fukushima
Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver.
Cancer research 1994;54(11):2895-9.
1994: Takashi Murai; Satoru Mori; M Hosono; Y Takeuchi; T Ohhara; Susumu Makino; Y Hayashi; R Takeda; Shoji Fukushima
Influences of aging and sex on renal pelvic carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice.
Cancer letters 1994;76(2-3):147-53.
1994: Takashi Murai; Satoru Mori; M Hosono; Y Takeuchi; T Oohara; Susumu Makino; R Takeda; Shoji Fukushima
Effect of phenacetin pretreatment on renal pelvic carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice of both sexes.
Teratogenesis, carcinogenesis, and mutagenesis 1994;14(4):193-201.
1993: T Otoshi; H Iwata; Shigeo Yamamoto; Takashi Murai; S Yamaguchi; Isao Matsui-Yuasa; Shuzo Otani; Shoji Fukushima
Severity of promotion by sodium salts of succinic acid in rat urinary bladder carcinogenesis correlates with sodium ion concentration under conditions of equal urinary pH.
Carcinogenesis 1993;14(11):2277-81.
1993: Takashi Murai; H Iwata; T Otoshi; Ginji Endo; S Horiguchi; Shoji Fukushima
Renal lesions induced in F344/DuCrj rats by 4-weeks oral administration of dimethylarsinic acid.
Toxicology letters 1993;66(1):53-61.
1992: Isao Matsui-Yuasa; Shuzo Otani; Yoshihisa Yano; Nobuyasu Takada; M A Shibata; Shoji Fukushima
Spermidine/spermine N1-acetyltransferase, a new biochemical marker for epithelial proliferation in rat bladder.
Japanese journal of cancer research : Gann 1992;83(10):1037-40.