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Yasushi Fukushima

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Phosphorylation

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Insulin Resistance

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Publications

TOP 3
Aikou Susumu; Fukushima Yasushi; Ogawa Masako; Nozaki Koji; Saito Toshihito; Matsui Toshimitsu; Goldenring James R; Kaminishi Michio; Nomura Sachiyo
Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice.
Koketsu Yuko; Sakoda Hideyuki; Fujishiro Midori; Kushiyama Akifumi; Fukushima Yasushi; Ono Hiraku; Anai Motonobu; Kikuchi Takako; Fukuda Takeshi; Kamata Hideaki; Horike Nanao; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.
Fujio Junko; Kushiyama Akifumi; Sakoda Hideyuki; Fujishiro Midori; Ogihara Takehide; Fukushima Yasushi; Anai Motonobu; Horike Nanao; Kamata Hideaki; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
Regulation of gut-derived resistin-like molecule beta expression by nutrients.

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All Publications

2009: Aikou Susumu; Fukushima Yasushi; Ogawa Masako; Nozaki Koji; Saito Toshihito; Matsui Toshimitsu; Goldenring James R; Kaminishi Michio; Nomura Sachiyo
Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice.
Digestive diseases and sciences 2009;54(8):1625-35.
2008: Koketsu Yuko; Sakoda Hideyuki; Fujishiro Midori; Kushiyama Akifumi; Fukushima Yasushi; Ono Hiraku; Anai Motonobu; Kikuchi Takako; Fukuda Takeshi; Kamata Hideaki; Horike Nanao; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.
American journal of physiology. Endocrinology and metabolism 2008;294(4):E719-25.
2008: Fujio Junko; Kushiyama Akifumi; Sakoda Hideyuki; Fujishiro Midori; Ogihara Takehide; Fukushima Yasushi; Anai Motonobu; Horike Nanao; Kamata Hideaki; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
Regulation of gut-derived resistin-like molecule beta expression by nutrients.
Diabetes research and clinical practice 2008;79(1):2-10.
2007: Ono Hiraku; Sakoda Hideyuki; Fujishiro Midori; Anai Motonobu; Kushiyama Akifumi; Fukushima Yasushi; Katagiri Hideki; Ogihara Takehide; Oka Yoshitomo; Kamata Hideaki; Horike Nanao; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.
American journal of physiology. Cell physiology 2007;293(5):C1576-85.
2006: Viana Amelia Y I; Sakoda Hideyuki; Anai Motonobu; Fujishiro Midori; Ono Hiraku; Kushiyama Akifumi; Fukushima Yasushi; Sato Yuzo; Oshida Yoshiharu; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.
Diabetes research and clinical practice 2006;73(2):135-42.
2006: Tateishi Keisuke; Ohta Miki; Guleng Bayasi; Kanai Fumihiko; Tanaka Yasuo; Asaoka Yoshinari; Jazag Amarsanaa; Imamura Jun; Imamura Takaaki; Ijichi Hideaki; Ikenoue Tsuneo; Kawakami Takayuki; Fukushima Yasushi; Washida Miwa; Sata Masataka; Miyagishi Makoto; Taira Kazunari; Yoshida Haruhiko; Kawabe Takao; Omata Masao
TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors.
International journal of cancer. Journal international du cancer 2006;118(9):2237-46.
2005: Kushiyama Akifumi; Shojima Nobuhiro; Ogihara Takehide; Inukai Kouichi; Sakoda Hideyuki; Fujishiro Midori; Fukushima Yasushi; Anai Motonobu; Ono Hiraku; Horike Nanao; Viana Amelia Y I; Uchijima Yasunobu; Nishiyama Koichi; Shimosawa Tatsuo; Fujita Toshiro; Katagiri Hideki; Oka Yoshitomo; Kurihara Hiroki; Asano Tomoichiro
Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.
The Journal of biological chemistry 2005;280(51):42016-25.
2005: Nakaya Muneo; Fukushima Yasushi; Takeuchi Naonobu; Kaga Kimitaka
Nasal allergic response mediated by histamine H3 receptors in murine allergic rhinitis.
The Laryngoscope 2005;115(10):1778-84.
2005: Guleng Bayasi; Tateishi Keisuke; Kanai Fumihiko; Jazag Amarsanaa; Ohta Miki; Asaoka Yoshinari; Ijichi Hideaki; Tanaka Yasuo; Imamura Jun; Ikenoue Tsuneo; Fukushima Yasushi; Morikane Keita; Miyagishi Makoto; Taira Kazunari; Kawabe Takao; Omata Masao
Cancer-derived VEGF plays no role in malignant ascites formation in the mouse.
World journal of gastroenterology : WJG 2005;11(35):5455-9.
2005: Sakoda Hideyuki; Fujishiro Midori; Fujio Junko; Shojima Nobuhiro; Ogihara Takehide; Kushiyama Akifumi; Fukushima Yasushi; Anai Motonobu; Ono Hiraku; Kikuchi Masatoshi; Horike Nanao; Viana Amelia Y I; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.
American journal of physiology. Endocrinology and metabolism 2005;289(3):E474-81.
2005: Guleng Bayasi; Tateishi Keisuke; Ohta Miki; Kanai Fumihiko; Jazag Amarsanaa; Ijichi Hideaki; Tanaka Yasuo; Washida Miwa; Morikane Keita; Fukushima Yasushi; Yamori Takao; Tsuruo Takashi; Kawabe Takao; Miyagishi Makoto; Taira Kazunari; Sata Masataka; Omata Masao
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner.
Cancer research 2005;65(13):5864-71.
2005: Ishikawa Takashi; Fukushima Yasushi; Shiobara Yujiro; Kishimoto Tsuyoshi; Tanno Sakiko; Shoji Ikuo; Suzuki Tetsuro; Matsui Tamano; Shimada Yasushi; Ohyama Takaaki; Nagai Ryozo; Miyamura Tatsuo
Outbreak of hepatitis C virus infection in an outpatient clinic.
Journal of gastroenterology and hepatology 2005;20(7):1087-93.
2005: Shojima N; Ogihara T; Inukai K; Fujishiro M; Sakoda H; Kushiyama A; Katagiri H; Anai M; Ono H; Fukushima Y; Horike N; Viana A Y I; Uchijima Y; Kurihara H; Asano T
Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.
Diabetologia 2005;48(5):984-92.
2005: Anai Motonobu; Shojima Nobuhiro; Katagiri Hideki; Ogihara Takehide; Sakoda Hideyuki; Onishi Yukiko; Ono Hiraku; Fujishiro Midori; Fukushima Yasushi; Horike Nanao; Viana Amelia; Kikuchi Masatoshi; Noguchi Noriko; Takahashi Shinichiro; Takata Kuniaki; Oka Yoshitomo; Uchijima Yasunobu; Kurihara Hiroki; Asano Tomoichiro
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
The Journal of biological chemistry 2005;280(18):18525-35.
2004: Fukushima Yasushi; Matsui Toshimitsu; Saitoh Toshihito; Ichinose Masao; Tateishi Keisuke; Shindo Takayuki; Fujishiro Midori; Sakoda Hideyuki; Shojima Nobuhiro; Kushiyama Akifumi; Fukuda Satoru; Anai Motonobu; Ono Hiraku; Oka Masashi; Shimizu Yasuhito; Kurihara Hiroki; Nagai Ryozo; Ishikawa Takashi; Asano Tomoichiro; Omata Masao
Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.
European journal of pharmacology 2004;502(3):243-52.
2004: Ogihara T; Asano T; Katagiri H; Sakoda H; Anai M; Shojima N; Ono H; Fujishiro M; Kushiyama A; Fukushima Y; Kikuchi M; Noguchi N; Aburatani H; Gotoh Y; Komuro I; Fujita T
Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.
Diabetologia 2004;47(5):794-805.
2004: Fukushima Yasushi
[Functional analyses of gastric mucosa using mice deficient in both histamine H2 receptor and CCKB/gastrin receptor]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(3):551-5.
2003: Ono Hiraku; Shimano Hitoshi; Katagiri Hideki; Yahagi Naoya; Sakoda Hideyuki; Onishi Yukiko; Anai Motonobu; Ogihara Takehide; Fujishiro Midori; Viana Amelia Y I; Fukushima Yasushi; Abe Miho; Shojima Nobuhiro; Kikuchi Masatoshi; Yamada Nobuhiro; Oka Yoshitomo; Asano Tomoichiro
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Diabetes 2003;52(12):2905-13.
2003: Sakoda Hideyuki; Gotoh Yukiko; Katagiri Hideki; Kurokawa Mineo; Ono Hiraku; Onishi Yukiko; Anai Motonobu; Ogihara Takehide; Fujishiro Midori; Fukushima Yasushi; Abe Miho; Shojima Nobuhiro; Kikuchi Masatoshi; Oka Yoshitomo; Hirai Hisamaru; Asano Tomoichiro
Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity.
The Journal of biological chemistry 2003;278(28):25802-7.
2003: Fukushima Yasushi; Shindo Takayuki; Anai Motonobu; Saitoh Toshihito; Wang Yuhui; Fujishiro Midori; Ohashi Yoshio; Ogihara Takehide; Inukai Kouichi; Ono Hiraku; Sakoda Hideyuki; Kurihara Yukiko; Honda Miho; Shojima Nobuhiro; Fukushima Harumi; Haraikawa-Onishi Yukiko; Katagiri Hideki; Shimizu Yasuhito; Ichinose Masao; Ishikawa Takashi; Omata Masao; Nagai Ryozo; Kurihara Hiroki; Asano Tomoichiro
Structural and functional characterization of gastric mucosa and central nervous system in histamine H2 receptor-null mice.
European journal of pharmacology 2003;468(1):47-58.
2003: Fujishiro Midori; Ogihara Takehide; Tsukuda Katsunori; Shojima Nobuhiro; Fukushima Yasushi; Kimura Satoshi; Oka Yoshitomo; Asano Tomoichiro
A case showing an association between type 1 diabetes mellitus and Kabuki syndrome.
Diabetes research and clinical practice 2003;60(1):25-31.
2003: Fujishiro Midori; Gotoh Yukiko; Katagiri Hideki; Sakoda Hideyuki; Ogihara Takehide; Anai Motonobu; Onishi Yukiko; Ono Hiraku; Abe Miho; Shojima Nobuhiro; Fukushima Yasushi; Kikuchi Masatoshi; Oka Yoshitomo; Asano Tomoichiro
Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2003;17(3):487-97.
2003: Fukushima Yasushi; Ishikawa Takashi; Saitoh Toshihito; Tateishi Keisuke; Ogihara Takehide; Fujishiro Midori; Shojima Nobuhiro; Honda Miho; Kushiyama Akifumi; Anai Motonobu; Sakoda Hideyuki; Ono Hiraku; Onishi Yukiko; Otsuka Hiroko; Katagiri Hideki; Nagai Ryozo; Omata Masao; Asano Tomoichiro
Extremely early onset of ranitidine action on human histamine H2 receptors expressed in HEK293 cells.
Digestion 2003;68(2-3):145-52.
2002: Ogihara Takehide; Asano Tomoichiro; Ando Katsuyuki; Chiba Yuko; Sakoda Hideyuki; Anai Motonobu; Shojima Nobuhiro; Ono Hiraku; Onishi Yukiko; Fujishiro Midori; Katagiri Hideki; Fukushima Yasushi; Kikuchi Masatoshi; Noguchi Noriko; Aburatani Hiroyuki; Komuro Issei; Fujita Toshiro
Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling.
Hypertension 2002;40(6):872-9.
2002: Song Haiyan; Shojima Nobuhiro; Sakoda Hideyuki; Ogihara Takehide; Fujishiro Midori; Katagiri Hideki; Anai Motonobu; Onishi Yukiko; Ono Hiraku; Inukai Kouichi; Fukushima Yasushi; Kikuchi Masatoshi; Shimano Hitoshi; Yamada Nobuhiro; Oka Yoshitomo; Asano Tomoichiro
Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules.
Biochemical and biophysical research communications 2002;299(2):291-8.
2002: Shindo Takayuki; Manabe Ichiro; Fukushima Yasushi; Tobe Kazuyuki; Aizawa Kenichi; Miyamoto Saku; Kawai-Kowase Keiko; Moriyama Nobuo; Imai Yasushi; Kawakami Hayato; Nishimatsu Hiroaki; Ishikawa Takashi; Suzuki Toru; Morita Hiroyuki; Maemura Koji; Sata Masataka; Hirata Yasunobu; Komukai Masayuki; Kagechika Hiroyuki; Kadowaki Takashi; Kurabayashi Masahiko; Nagai Ryozo
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Nature medicine 2002;8(8):856-63.
2002: Saito Makiko; Fukushima Yasushi; Tatsumi Ken; Bei Lin; Fujiki Yukio; Iwamori Masao; Igarashi Takashi; Sakakihara Yoichi
Molecular cloning of Chinese hamster ceramide glucosyltransferase and its enhanced expression in peroxisome-defective mutant Z65 cells.
Archives of biochemistry and biophysics 2002;403(2):171-8.
2002: Ogihara Takehide; Asano Tomoichiro; Ando Katsuyuki; Sakoda Hideyuki; Anai Motonobu; Shojima Nobuhiro; Ono Hiraku; Onishi Yukiko; Fujishiro Midori; Abe Miho; Fukushima Yasushi; Kikuchi Masatoshi; Fujita Toshiro
High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats.
Hypertension 2002;40(1):83-9.
2002: Shojima Nobuhiro; Sakoda Hideyuki; Ogihara Takehide; Fujishiro Midori; Katagiri Hideki; Anai Motonobu; Onishi Yukiko; Ono Hiraku; Inukai Kouichi; Abe Miho; Fukushima Yasushi; Kikuchi Masatoshi; Oka Yoshitomo; Asano Tomoichiro
Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
Diabetes 2002;51(6):1737-44.
2002: Sakoda Hideyuki; Ogihara Takehide; Anai Motonobu; Fujishiro Midori; Ono Hiraku; Onishi Yukiko; Katagiri Hideki; Abe Miho; Fukushima Yasushi; Shojima Nobuhiro; Inukai Kouichi; Kikuchi Masatoshi; Oka Yoshitomo; Asano Tomoichiro
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1239-44.
2001: Onishi-Haraikawa Y; Funaki M; Gotoh N; Shibuya M; Inukai K; Katagiri H; Fukushima Y; Anai M; Ogihara T; Sakoda H; Ono H; Kikuchi M; Oka Y; Asano T
Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.
Biochemical and biophysical research communications 2001;288(2):476-82.
2001: Ono H; Katagiri H; Funaki M; Anai M; Inukai K; Fukushima Y; Sakoda H; Ogihara T; Onishi Y; Fujishiro M; Kikuchi M; Oka Y; Asano T
Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1411-22.
2001: Fukushima Y; Saitoh T; Anai M; Ogihara T; Inukai K; Funaki M; Sakoda H; Onishi Y; Ono H; Fujishiro M; Ishikawa T; Takata K; Nagai R; Omata M; Asano T
Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting.
Biochimica et biophysica acta 2001;1539(3):181-91.
2001: Fujishiro M; Gotoh Y; Katagiri H; Sakoda H; Ogihara T; Anai M; Onishi Y; Ono H; Funaki M; Inukai K; Fukushima Y; Kikuchi M; Oka Y; Asano T
MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression.
The Journal of biological chemistry 2001;276(23):19800-6.
2001: Ogihara T; Asano T; Ando K; Chiba Y; Sekine N; Sakoda H; Anai M; Onishi Y; Fujishiro M; Ono H; Shojima N; Inukai K; Fukushima Y; Kikuchi M; Fujita T
Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats.
Diabetes 2001;50(3):573-83.
2001: Inukai K; Funaki M; Anai M; Ogihara T; Katagiri H; Fukushima Y; Sakoda H; Onishi Y; Ono H; Fujishiro M; Abe M; Oka Y; Kikuchi M; Asano T
Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.
FEBS letters 2001;490(1-2):32-8.
2001: Fukushima Y; Saitoh T; Anai M; Tsukuda K; Onishi Y; Sakoda H; Inukai K; Ogihara T; Funaki M; Ono H; Fujishiro M; Ishikawa T; Nagai R; Omata M; Asano T
G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure.
The pharmacogenomics journal 2001;1(1):78-83.
2001: Fukushima Y; Otsuka H; Ishikawa M; Asano T; Anai M; Katsube T; Ogawa K; Kajiwara T; Ohkawa S; Ishikawa T; Omata M; Saitoh T
Potent and long-lasting action of lafutidine on the human histamine H(2) receptor.
Digestion 2001;64(3):155-60.
2000: Sakoda H; Ogihara T; Anai M; Funaki M; Inukai K; Katagiri H; Fukushima Y; Onishi Y; Ono H; Fujishiro M; Kikuchi M; Oka Y; Asano T
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.
Diabetes 2000;49(10):1700-8.
2000: Asano T; Kanda A; Katagiri H; Nawano M; Ogihara T; Inukai K; Anai M; Fukushima Y; Yazaki Y; Kikuchi M; Hooshmand-Rad R; Heldin C H; Oka Y; Funaki M
p110beta is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity.
The Journal of biological chemistry 2000;275(23):17671-6.
2000: Inukai K; Funaki M; Nawano M; Katagiri H; Ogihara T; Anai M; Onishi Y; Sakoda H; Ono H; Fukushima Y; Kikuchi M; Oka Y; Asano T
The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin.
The Biochemical journal 2000;346 Pt 2():483-9.
1999: Fukushima Y; Ohmachi Y; Asano T; Nawano M; Funaki M; Anai M; Ogihara T; Inukai K; Onishi Y; Sakoda H; Saitoh T; Matsuhashi N; Yazaki Y; Sugano K
Localization of the histamine H(2) receptor, a target for antiulcer drugs, in gastric parietal cells.
Digestion 1999;60(6):522-7.
1999: Nawano M; Anai M; Funaki M; Kobayashi H; Kanda A; Fukushima Y; Inukai K; Ogihara T; Sakoda H; Onishi Y; Kikuchi M; Yazaki Y; Oka Y; Asano T
Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.
Metabolism: clinical and experimental 1999;48(10):1248-55.
1999: Funaki M; Katagiri H; Kanda A; Anai M; Nawano M; Ogihara T; Inukai K; Fukushima Y; Ono H; Yazaki Y; Kikuchi M; Oka Y; Asano T
p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring.
The Journal of biological chemistry 1999;274(31):22019-24.
1999: Sakoda H; Ogihara T; Anai M; Funaki M; Inukai K; Katagiri H; Fukushima Y; Onishi Y; Ono H; Yazaki Y; Kikuchi M; Oka Y; Asano T
No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes.
Diabetes 1999;48(7):1365-71.
1999: Anai M; Funaki M; Ogihara T; Kanda A; Onishi Y; Sakoda H; Inukai K; Nawano M; Fukushima Y; Yazaki Y; Kikuchi M; Oka Y; Asano T
Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats.
Diabetes 1999;48(1):158-69.
1998: Anai M; Ono H; Funaki M; Fukushima Y; Inukai K; Ogihara T; Sakoda H; Onishi Y; Yazaki Y; Kikuchi M; Oka Y; Asano T
Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2.
The Journal of biological chemistry 1998;273(45):29686-92.
1998: Terasaki J; Anai M; Funaki M; Shibata T; Inukai K; Ogihara T; Ishihara H; Katagiri H; Onishi Y; Sakoda H; Fukushima Y; Yazaki Y; Kikuchi M; Oka Y; Asano T
Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet.
Diabetologia 1998;41(4):400-9.
1998: Anai M; Funaki M; Ogihara T; Terasaki J; Inukai K; Katagiri H; Fukushima Y; Yazaki Y; Kikuchi M; Oka Y; Asano T
Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats.
Diabetes 1998;47(1):13-23.
1997: Ogihara T; Isobe T; Ichimura T; Taoka M; Funaki M; Sakoda H; Onishi Y; Inukai K; Anai M; Fukushima Y; Kikuchi M; Yazaki Y; Oka Y; Asano T
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
The Journal of biological chemistry 1997;272(40):25267-74.
1997: Kadowaki H; Takahashi Y; Ando A; Momomura K; Kaburagi Y; Quin J D; MacCuish A C; Koda N; Fukushima Y; Taylor S I; Akanuma Y; Yazaki Y; Kadowaki T
Four mutant alleles of the insulin receptor gene associated with genetic syndromes of extreme insulin resistance.
Biochemical and biophysical research communications 1997;237(3):516-20.
1997: Fukushima Y; Asano T; Takata K; Funaki M; Ogihara T; Anai M; Tsukuda K; Saitoh T; Katagiri H; Aihara M; Matsuhashi N; Oka Y; Yazaki Y; Sugano K
Role of the C terminus in histamine H2 receptor signaling, desensitization, and agonist-induced internalization.
The Journal of biological chemistry 1997;272(31):19464-70.
1997: Fukushima Y; Asano T; Saitoh T; Anai M; Funaki M; Ogihara T; Katagiri H; Matsuhashi N; Yazaki Y; Sugano K
Oligomer formation of histamine H2 receptors expressed in Sf9 and COS7 cells.
FEBS letters 1997;409(2):283-6.
1997: Ogihara T; Shin B C; Anai M; Katagiri H; Inukai K; Funaki M; Fukushima Y; Ishihara H; Takata K; Kikuchi M; Yazaki Y; Oka Y; Asano T
Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells.
The Journal of biological chemistry 1997;272(19):12868-73.
1997: Takahashi Y; Kadowaki H; Momomura K; Fukushima Y; Orban T; Okai T; Taketani Y; Akanuma Y; Yazaki Y; Kadowaki T
A homozygous kinase-defective mutation in the insulin receptor gene in a patient with leprechaunism.
Diabetologia 1997;40(4):412-20.
1997: Inukai K; Takata K; Asano T; Katagiri H; Ishihara H; Nakazaki M; Fukushima Y; Yazaki Y; Kikuchi M; Oka Y
Targeting of GLUT1-GLUT5 chimeric proteins in the polarized cell line Caco-2.
Molecular endocrinology (Baltimore, Md.) 1997;11(4):442-9.
1997: Inukai K; Funaki M; Ogihara T; Katagiri H; Kanda A; Anai M; Fukushima Y; Hosaka T; Suzuki M; Shin B C; Takata K; Yazaki Y; Kikuchi M; Oka Y; Asano T
p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.
The Journal of biological chemistry 1997;272(12):7873-82.
1997: Takahashi Y; Tobe K; Kadowaki H; Katsumata D; Fukushima Y; Yazaki Y; Akanuma Y; Kadowaki T
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.
Endocrinology 1997;138(2):741-50.
1996: Fukushima Y; Asano T; Katagiri H; Aihara M; Saitoh T; Anai M; Funaki M; Ogihara T; Inukai K; Matsuhashi N; Oka Y; Yazaki Y; Sugano K
Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells.
The Biochemical journal 1996;320 ( Pt 1)():27-32.
1996: Fukushima Y; Sugano K
[Structural analysis of the histamine H2 receptor]
Nippon rinsho. Japanese journal of clinical medicine 1996;54(4):1144-8.
1996: Inukai K; Anai M; Van Breda E; Hosaka T; Katagiri H; Funaki M; Fukushima Y; Ogihara T; Yazaki Y; Kikuchi; Oka Y; Asano T
A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene.
The Journal of biological chemistry 1996;271(10):5317-20.
1995: Fukushima Y; Oka Y; Saitoh T; Katagiri H; Asano T; Matsuhashi N; Takata K; van Breda E; Yazaki Y; Sugano K
Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action.
The Biochemical journal 1995;310 ( Pt 2)():553-8.
1995: Katagiri H; Terasaki J; Murata T; Ishihara H; Ogihara T; Inukai K; Fukushima Y; Anai M; Kikuchi M; Miyazaki J
A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells.
The Journal of biological chemistry 1995;270(10):4963-6.
1994: Fukushima Y; Matsuhashi N; Saitoh T; Mori H; Kodama T; Sugano K; Yazaki Y
Expression of histamine H2 receptor in Chinese hamster ovary cells: a probe to study the desensitization mechanism.
Journal of gastroenterology 1994;29 Suppl 7():68-72.
1993: Sugano K; Yoshida Y; Fukushima Y; Katoh M; Matsuhashi N; Yazaki Y; Fukuchi S
Negative feedback regulation of acid secretion: linkage of acid secretion and mucosal defense.
Gastroenterologia Japonica 1993;28 Suppl 5():118-21.
1993: Fukushima Y; Oka Y; Katagiri H; Saitoh T; Asano T; Ishihara H; Matsuhashi N; Kodama T; Yazaki Y; Sugano K
Desensitization of canine histamine H2 receptor expressed in Chinese hamster ovary cells.
Biochemical and biophysical research communications 1993;190(3):1149-55.

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