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Jon Fukuto

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Christopher H Switzer; Thomas W Miller; Patrick J Farmer; Jon M Fukuto
Synthesis and characterization of lithium oxonitrate (LiNO).
Nestor E Francoleon; Samantha J Carrington; Jon M Fukuto
The reaction of H(2)S with oxidized thiols: generation of persulfides and implications to H(2)S biology.
Wilmarie Flores-Santana; Debra J Salmon; Sonia Donzelli; Christopher H Switzer; Debashree Basudhar; Lisa A Ridnour; Robert Cheng; Sharon Anneve Glynn; Nazareno Paolocci; Jon M Fukuto; Katrina M Miranda; David A Wink
The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.

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All Publications

2013: Christopher H Switzer; Thomas W Miller; Patrick J Farmer; Jon M Fukuto
Synthesis and characterization of lithium oxonitrate (LiNO).
Journal of inorganic biochemistry 2013;118():128-33.
2011: Nestor E Francoleon; Samantha J Carrington; Jon M Fukuto
The reaction of H(2)S with oxidized thiols: generation of persulfides and implications to H(2)S biology.
Archives of biochemistry and biophysics 2011;516(2):146-53.
2011: Wilmarie Flores-Santana; Debra J Salmon; Sonia Donzelli; Christopher H Switzer; Debashree Basudhar; Lisa A Ridnour; Robert Cheng; Sharon Anneve Glynn; Nazareno Paolocci; Jon M Fukuto; Katrina M Miranda; David A Wink
The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
Antioxidants & redox signaling 2011;14(9):1659-74.
2010: Alexis D Ostrowski; Sherine J Deakin; Bilal Azhar; Thomas W Miller; Nestor Franco; Melisa M Cherney; Andrea J Lee; Judith N Burstyn; Jon M Fukuto; Ian L Megson; Peter C Ford
Nitric oxide photogeneration from trans-Cr(cyclam)(ONO)(2)(+) in a reducing environment. activation of soluble guanylyl cyclase and arterial vasorelaxation.
Journal of medicinal chemistry 2010;53(2):715-22.
2009: Matthew I Jackson; Tae H Han; Laura Serbulea; Andrew Dutton; Eleonora Ford; Katrina M Miranda; K N Houk; David A Wink; Jon M Fukuto
Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications.
Free radical biology & medicine 2009;47(8):1130-9.
2009: Thomas W Miller; Melisa M Cherney; Andrea J Lee; Nestor E Francoleon; Patrick J Farmer; S Bruce King; Adrian J Hobbs; Katrina M Miranda; Judith N Burstyn; Jon M Fukuto
The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols.
The Journal of biological chemistry 2009;284(33):21788-96.
2009: Wilmarie Flores-Santana; Christopher H Switzer; Lisa A Ridnour; Debashree Basudhar; Daniele Mancardi; Sonia Donzelli; Douglas D Thomas; Katrina M Miranda; Jon M Fukuto; David A Wink
Comparing the chemical biology of NO and HNO.
Archives of pharmacal research 2009;32(8):1139-53.
2009: Christopher H Switzer; Wilmarie Flores-Santana; Daniele Mancardi; Sonia Donzelli; Debashree Basudhar; Lisa A Ridnour; Katrina M Miranda; Jon M Fukuto; Nazareno Paolocci; David A Wink
The emergence of nitroxyl (HNO) as a pharmacological agent.
Biochimica et biophysica acta 2009;1787(7):835-40.
2008: Henry Jay Forman; Jon M Fukuto; Tom Miller; Hongqiao Zhang; Alessandra Rinna; Smadar Levy
The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal.
Archives of biochemistry and biophysics 2008;477(2):183-95.
2008: Alberto Bindoli; Jon M Fukuto; Henry Jay Forman
Thiol chemistry in peroxidase catalysis and redox signaling.
Antioxidants & redox signaling 2008;10(9):1549-64.
2008: Shehla Pervin; An H Tran; Shaghayegh Zekavati; Jon M Fukuto; Rajan Singh; Gautam Chaudhuri
Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.
Cancer research 2008;68(12):4862-74.
2008: Andrew J Norris; Maryam R Sartippour; Ming Lu; Taylor Park; Jian Yu Rao; Matthew I Jackson; Jon M Fukuto; Mai N Brooks
Nitroxyl inhibits breast tumor growth and angiogenesis.
International journal of cancer. Journal international du cancer 2008;122(8):1905-10.
2008: Jon M Fukuto; Matthew I Jackson; Nina Kaludercic; Nazareno Paolocci
Examining nitroxyl in biological systems.
Methods in enzymology 2008;440():411-31.
2007: Brenda E Lopez; David A Wink; Jon M Fukuto
The inhibition of glyceraldehyde-3-phosphate dehydrogenase by nitroxyl (HNO).
Archives of biochemistry and biophysics 2007;465(2):430-6.
2007: Brenda E Lopez; masaru shinyashiki; Tae H Han; Jon M Fukuto
Antioxidant actions of nitroxyl (HNO).
Free radical biology & medicine 2007;42(4):482-91.
2007: Nazareno Paolocci; Matthew I Jackson; Brenda E Lopez; Katrina M Miranda; Carlo G Tocchetti; David A Wink; Adrian J Hobbs; Jon M Fukuto
The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO.
Pharmacology & therapeutics 2007;113(2):442-58.
2007: Jon M Fukuto; Michael D Collins
Interactive endogenous small molecule (gaseous) signaling: implications for teratogenesis.
Current pharmaceutical design 2007;13(29):2952-78.
2006: Melanie Madhani; Apurba K Patra; Thomas W Miller; Aura A Eroy-Reveles; Adrian J Hobbs; Jon M Fukuto; Pradip Mascharak
Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta.
Journal of medicinal chemistry 2006;49(25):7325-30.
2006: William A Pryor; Kendall N Houk; Christopher S Foote; Jon M Fukuto; Louis J Ignarro; Giuseppe Squadrito; Kelvin J A Davies
Free radical biology and medicine: it's a gas, man!
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(3):R491-511.
2006: Andrew S Dutton; Christopher P Suhrada; Katrina M Miranda; David A Wink; Jon M Fukuto; Kendall N Houk
Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations.
Inorganic chemistry 2006;45(6):2448-56.
2006: Sonia Donzelli; Michael G Espey; Douglas D Thomas; Daniele Mancardi; Carlo G Tocchetti; Lisa A Ridnour; Nazareno Paolocci; S Bruce King; Katrina M Miranda; Giuseppe Lazzarino; Jon M Fukuto; David A Wink
Discriminating formation of HNO from other reactive nitrogen oxide species.
Free radical biology & medicine 2006;40(6):1056-66.
2005: Katrina M Miranda; Tatsuo Katori; Claudia L Torres de Holding; Lynta Thomas; Lisa A Ridnour; William J McLendon; Stephanie M Cologna; Andrew S Dutton; Hunter C Champion; Daniele Mancardi; Carlo G Tocchetti; Joseph E Saavedra; Larry K Keefer; Kendall N Houk; Jon M Fukuto; David A Kass; Nazareno Paolocci; David A Wink
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.
Journal of medicinal chemistry 2005;48(26):8220-8.
2005: Brenda E Lopez; Chester E Rodriguez; Mochtar Pribadi; Natalie M Cook; masaru shinyashiki; Jon M Fukuto
Inhibition of yeast glycolysis by nitroxyl (HNO): mechanism of HNO toxicity and implications to HNO biology.
Archives of biochemistry and biophysics 2005;442(1):140-8.
2005: Matthew Alan Wallace; Sasaneh Bailey; Jon M Fukuto; Joan Selverstone Valentine; Edith Butler Gralla
Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of superoxide in the toxicity of redox-cycling compounds.
Chemical research in toxicology 2005;18(8):1279-86.
2005: Chester E Rodriguez; Jon M Fukuto; Keiko Taguchi; John R Froines; Arthur K Cho
The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions.
Chemico-biological interactions 2005;155(1-2):97-110.
2005: Andrew S Dutton; Jon M Fukuto; Kendall N Houk
Theoretical reduction potentials for nitrogen oxides from CBS-QB3 energetics and (C)PCM solvation calculations.
Inorganic chemistry 2005;44(11):4024-8.
2005: Jon M Fukuto; Michael D Bartberger; Andrew S Dutton; Nazareno Paolocci; David A Wink; Kendall N Houk
The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide.
Chemical research in toxicology 2005;18(5):790-801.
2005: Jon M Fukuto; Andrew S Dutton; Kendall N Houk
The chemistry and biology of nitroxyl (HNO): a chemically unique species with novel and important biological activity.
Chembiochem : a European journal of chemical biology 2005;6(4):612-9.
2005: Katrina M Miranda; Andrew S Dutton; Lisa A Ridnour; Christian A Foreman; Eleonora Ford; Nazareno Paolocci; Tatsuo Katori; Carlo G Tocchetti; Daniele Mancardi; Douglas D Thomas; Michael G Espey; Kendall N Houk; Jon M Fukuto; David A Wink
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
Journal of the American Chemical Society 2005;127(2):722-31.
2005: masaru shinyashiki; Brenda E Lopez; Chester E Rodriguez; Jon M Fukuto
Yeast model systems for examining nitrogen oxide biochemistry/signaling.
Methods in enzymology 2005;396():301-16.
2005: Andrew S Dutton; Jon M Fukuto; Kendall N Houk
Quantum mechanical determinations of reaction mechanisms, acid base, and redox properties of nitrogen oxides and their donors.
Methods in enzymology 2005;396():26-44.
2005: Jon M Fukuto; Christopher H Switzer; Katrina M Miranda; David A Wink
Nitroxyl (HNO): chemistry, biochemistry, and pharmacology.
Annual review of pharmacology and toxicology 2005;45():335-55.
2004: Angelica P Olcott; Georges Tocco; Jide Tian; Dan Zekzer; Jon M Fukuto; Louis J Ignarro; Daniel L Kaufman
A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection.
Diabetes 2004;53(10):2574-80.
2004: Chester E Rodriguez; masaru shinyashiki; John R Froines; Rong Chun Yu; Jon M Fukuto; Arthur K Cho
An examination of quinone toxicity using the yeast Saccharomyces cerevisiae model system.
Toxicology 2004;201(1-3):185-96.
2004: Michael P Bova; Matthew N Mattson; Stefan Vasile; Danny Tam; Leslie Holsinger; Meire Bremer; Terence Hui; Gerald McMahon; Audie Rice; Jon M Fukuto
The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.
Archives of biochemistry and biophysics 2004;429(1):30-41.
2004: masaru shinyashiki; Chuan-Ju G Pan; Brenda E Lopez; Jon M Fukuto
Inhibition of the yeast metal reductase heme protein fre1 by nitric oxide (NO): a model for inhibition of NADPH oxidase by NO.
Free radical biology & medicine 2004;37(5):713-23.
2004: Chuan-Ju G Pan; Debra A Schmitz; Arthur K Cho; John R Froines; Jon M Fukuto
Inherent redox properties of diesel exhaust particles: catalysis of the generation of reactive oxygen species by biological reductants.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):225-32.
2004: Henry Jay Forman; Jon M Fukuto; Martine Torres
Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers.
American journal of physiology. Cell physiology 2004;287(2):C246-56.
2004: Andrew S Dutton; Jon M Fukuto; Kendall N Houk
Mechanisms of HNO and NO production from Angeli's salt: density functional and CBS-QB3 theory predictions.
Journal of the American Chemical Society 2004;126(12):3795-800.
2004: Tae H Han; Jon M Fukuto; James C Liao
Reductive nitrosylation and S-nitrosation of hemoglobin in inhomogeneous nitric oxide solutions.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2004;10(2):74-82.
2004: Andrew S Dutton; Jon M Fukuto; Kendall N Houk
The mechanism of NO formation from the decomposition of dialkylamino diazeniumdiolates: density functional theory and CBS-QB3 predictions.
Inorganic chemistry 2004;43(3):1039-45.
2004: Lisa A Ridnour; Douglas D Thomas; Daniele Mancardi; Michael G Espey; Katrina M Miranda; Nazareno Paolocci; Martin Feelisch; Jon M Fukuto; David A Wink
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations.
Biological chemistry 2004;385(1):1-10.
2003: David A Wink; Katrina M Miranda; Tatsuo Katori; Daniele Mancardi; Douglas D Thomas; Lisa A Ridnour; Michael G Espey; Martin Feelisch; Carol A. Colton; Jon M Fukuto; Pasquale Pagliaro; David A Kass; Nazareno Paolocci
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2264-76.
2003: Jennifer Y Cho; Andrew S Dutton; Tom Miller; Kendall N Houk; Jon M Fukuto
Oxidation of N-hydroxyguanidines by copper(II): model systems for elucidating the physiological chemistry of the nitric oxide biosynthetic intermediate N-hydroxyl-L-arginine.
Archives of biochemistry and biophysics 2003;417(1):65-76.
2003: Katrina M Miranda; Nazareno Paolocci; Tatsuo Katori; Douglas D Thomas; Eleonora Ford; Michael D Bartberger; Michael G Espey; David A Kass; Martin Feelisch; Jon M Fukuto; David A Wink
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9196-201.
2003: Nazareno Paolocci; Tatsuo Katori; Hunter C Champion; Marcus E St John; Katrina M Miranda; Jon M Fukuto; David A Wink; David A Kass
Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5537-42.
2003: Natalie M Cook; masaru shinyashiki; Matthew I Jackson; Felipe A Leal; Jon M Fukuto
Nitroxyl-mediated disruption of thiol proteins: inhibition of the yeast transcription factor Ace1.
Archives of biochemistry and biophysics 2003;410(1):89-95.
2003: Katrina M Miranda; Raymond W Nims; Douglas D Thomas; Michael G Espey; Deborah Citrin; Michael D Bartberger; Nazareno Paolocci; Jon M Fukuto; Martin Feelisch; David A Wink
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.
Journal of inorganic biochemistry 2003;93(1-2):52-60.
2002: Michael D Bartberger; Wei Liu; Eleonora Ford; Katrina M Miranda; Christopher H Switzer; Jon M Fukuto; Patrick J Farmer; David A Wink; Kendall N Houk
The reduction potential of nitric oxide (NO) and its importance to NO biochemistry.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):10958-63.
2002: Tae H Han; Daniel R Hyduke; Mark W Vaughn; Jon M Fukuto; James C Liao
Nitric oxide reaction with red blood cells and hemoglobin under heterogeneous conditions.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7763-8.
2002: Henry Jay Forman; Martine Torres; Jon M Fukuto
Redox signaling.
Molecular and cellular biochemistry 2002;234-235(1-2):49-62.
2001: masaru shinyashiki; Chuan-Ju G Pan; Christopher H Switzer; Jon M Fukuto
Mechanisms of nitrogen oxide-mediated disruption of metalloprotein function: an examination of the copper-responsive yeast transcription factor Ace1.
Chemical research in toxicology 2001;14(12):1584-9.
2001: PM Bauer; Georgette M Buga; Jon M Fukuto; Anthony E Pegg; Louis J Ignarro
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme.
The Journal of biological chemistry 2001;276(37):34458-64.
2001: Nazareno Paolocci; Walter F Saavedra; Katrina M Miranda; C Martignani; Takayoshi Isoda; Joshua M Hare; Michael G Espey; Jon M Fukuto; Martin Feelisch; David A Wink; David A Kass
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10463-8.
2001: Michael D Bartberger; Jon M Fukuto; Kendall N Houk
On the acidity and reactivity of HNO in aqueous solution and biological systems.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2194-8.
2001: Katrina M Miranda; Michael G Espey; Kenichi Yamada; M Krishna; N Ludwick; S Kim; David Jourd'heuil; Matthew B Grisham; Martin Feelisch; Jon M Fukuto; David A Wink
Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion.
The Journal of biological chemistry 2001;276(3):1720-7.
2000: KT Chiang; Christopher H Switzer; K O Akali; Jon M Fukuto
The role of oxygen and reduced oxygen species in nitric oxide-mediated cytotoxicity: studies in the yeast Saccharomyces cerevisiae model system.
Toxicology and applied pharmacology 2000;167(1):30-6.
2000: KT Chiang; masaru shinyashiki; Christopher H Switzer; Joan Selverstone Valentine; Edith Butler Gralla; D J Thiele; Jon M Fukuto
Effects of nitric oxide on the copper-responsive transcription factor Ace1 in Saccharomyces cerevisiae: cytotoxic and cytoprotective actions of nitric oxide.
Archives of biochemistry and biophysics 2000;377(2):296-303.
2000: masaru shinyashiki; KT Chiang; Christopher H Switzer; Edith Butler Gralla; Joan Selverstone Valentine; D J Thiele; Jon M Fukuto
The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2491-6.
2000: Michael G Espey; Katrina M Miranda; Martin Feelisch; Jon M Fukuto; M B Grisham; Michael P. Vitek; David A Wink
Mechanisms of cell death governed by the balance between nitrosative and oxidative stress.
Annals of the New York Academy of Sciences 2000;899():209-21.
1999: Xin L Ma; Feng Gao; GL Liu; Bernard L Lopez; Theodore A Christopher; Jon M Fukuto; D A Wink; Martin Feelisch
Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14617-22.
1999: J Hyun; G Chaudhuri; Jon M Fukuto
The reductive metabolism of nitric oxide in hepatocytes: possible interaction with thiols.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(9):1005-9.
1999: PM Bauer; Jon M Fukuto; Georgette M Buga; Anthony E Pegg; Louis J Ignarro
Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation.
Biochemical and biophysical research communications 1999;262(2):355-8.
1999: P S Wong; Jon M Fukuto
Reaction of organic nitrate esters and S-nitrosothiols with reduced flavins: a possible mechanism of bioactivation.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(4):502-9.
1999: Jon M Fukuto; D A Wink
Nitric oxide (NO): formation and biological roles in mammalian systems.
Metal ions in biological systems 1999;36():547-95.
1998: Georgette M Buga; Liu Hua Wei; PM Bauer; Jon M Fukuto; Louis J Ignarro
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms.
The American journal of physiology 1998;275(4 Pt 2):R1256-64.
1998: P S Wong; J Hyun; Jon M Fukuto; Frances N Shirota; Eugene G DeMaster; Don W Shoeman; Herbert T Nagasawa
Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry.
Biochemistry 1998;37(16):5362-71.
1998: David A Wink; Martin Feelisch; Jon M Fukuto; D Chistodoulou; David Jourd'heuil; Matthew B Grisham; Y Vodovotz; John A Cook; M Krishna; William DeGraff; S Kim; Janet Gamson; James B Mitchell
The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO.
Archives of biochemistry and biophysics 1998;351(1):66-74.
1995: J Yoo; Jon M Fukuto
Oxidation of N-hydroxyguanidine by nitric oxide and the possible generation of vasoactive species.
Biochemical pharmacology 1995;50(12):1995-2000.
1995: T Hayashi; Jon M Fukuto; Louis J Ignarro; Gautam Chaudhuri
Gender differences in atherosclerosis: possible role of nitric oxide.
Journal of cardiovascular pharmacology 1995;26(5):792-802.
1995: Herbert T Nagasawa; S P Kawle; J A Elberling; Eugene G DeMaster; Jon M Fukuto
Prodrugs of nitroxyl as potential aldehyde dehydrogenase inhibitors vis-a-vis vascular smooth muscle relaxants.
Journal of medicinal chemistry 1995;38(11):1865-71.
1995: Y Komori; J Hyun; K Chiang; Jon M Fukuto
The role of thiols in the apparent activation of rat brain nitric oxide synthase (NOS).
Journal of biochemistry 1995;117(4):923-7.
1995: J Hyun; Y Komori; Gautam Chaudhuri; Louis J Ignarro; Jon M Fukuto
The protective effect of tetrahydrobiopterin on the nitric oxide-mediated inhibition of purified nitric oxide synthase.
Biochemical and biophysical research communications 1995;206(1):380-6.
1995: Jon M Fukuto
Chemistry of nitric oxide: biologically relevant aspects.
Advances in pharmacology (San Diego, Calif.) 1995;34():1-15.
1995: Jon M Fukuto; Gautam Chaudhuri
Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition.
Annual review of pharmacology and toxicology 1995;35():165-94.
1994: Y Komori; G C Wallace; Jon M Fukuto
Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs.
Archives of biochemistry and biophysics 1994;315(2):213-8.
1994: A J Hobbs; Jon M Fukuto; Louis J Ignarro
Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10992-6.
1994: J M Griscavage; Jon M Fukuto; Y Komori; Louis J Ignarro
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
The Journal of biological chemistry 1994;269(34):21644-9.
1994: Jon M Fukuto; P Gulati; Herbert T Nagasawa
Involvement of nitroxyl (HNO) in the cyanamide-induced vasorelaxation of rabbit aorta.
Biochemical pharmacology 1994;47(5):922-4.
1993: Y Komori; K T Chiang; Jon M Fukuto
The effect of nonionic detergents on the activity and/or stability of rat brain nitric oxide synthase.
Archives of biochemistry and biophysics 1993;307(2):311-5.
1993: Jon M Fukuto; A J Hobbs; Louis J Ignarro
Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO.
Biochemical and biophysical research communications 1993;196(2):707-13.
1993: Jon M Fukuto; Dennis J Stuehr; P L Feldman; Michael P Bova; P Wong
Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase.
Journal of medicinal chemistry 1993;36(18):2666-70.
1993: Louis J Ignarro; Jon M Fukuto; J M Griscavage; NE Rogers; R E Byrns
Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8103-7.
1992: T Hayashi; Jon M Fukuto; Louis J Ignarro; Gautam Chaudhuri
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11259-63.
1992: Jon M Fukuto; K Chiang; R Hszieh; P Wong; Gautam Chaudhuri
The pharmacological activity of nitroxyl: a potent vasodilator with activity similar to nitric oxide and/or endothelium-derived relaxing factor.
The Journal of pharmacology and experimental therapeutics 1992;263(2):546-51.
1992: Jon M Fukuto; R Hszieh; P Gulati; K T Chiang; Herbert T Nagasawa
N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties.
Biochemical and biophysical research communications 1992;187(3):1367-73.
1992: Jon M Fukuto; G C Wallace; R Hszieh; Gautam Chaudhuri
Chemical oxidation of N-hydroxyguanidine compounds. Release of nitric oxide, nitroxyl and possible relationship to the mechanism of biological nitric oxide generation.
Biochemical pharmacology 1992;43(3):607-13.
1991: J F Brady; H Ishizaki; Jon M Fukuto; M C Lin; A Fadel; J M Gapac; Chung S Yang
Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites.
Chemical research in toxicology 1991;4(6):642-7.
1991: Jon M Fukuto; Y Kumagai; Arthur K Cho
Determination of the mechanism of demethylenation of (methylenedioxy)phenyl compounds by cytochrome P450 using deuterium isotope effects.
Journal of medicinal chemistry 1991;34(9):2871-6.
1991: N Patel; Y Kumagai; S E Unger; Jon M Fukuto; Arthur K Cho
Transformation of dopamine and alpha-methyldopamine by NG108-15 cells: formation of thiol adducts.
Chemical research in toxicology 1991;4(4):421-6.
1991: G C Wallace; Jon M Fukuto
Synthesis and bioactivity of N omega-hydroxyarginine: a possible intermediate in the biosynthesis of nitric oxide from arginine.
Journal of medicinal chemistry 1991;34(5):1746-8.
1991: G C Wallace; P Gulati; Jon M Fukuto
N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery.
Biochemical and biophysical research communications 1991;176(1):528-34.
1991: J F Brady; Mong-Heng Wang; JY Hong; F Xiao; Y Li; J S Yoo; S M Ning; Mao-Jung Lee; Jon M Fukuto; J M Gapac
Modulation of rat hepatic microsomal monooxygenase enzymes and cytotoxicity by diallyl sulfide.
Toxicology and applied pharmacology 1991;108(2):342-54.
1991: Georgette M Buga; M E Gold; Jon M Fukuto; Louis J Ignarro
Shear stress-induced release of nitric oxide from endothelial cells grown on beads.
Hypertension 1991;17(2):187-93.
1991: J N Burstyn; M Iskandar; J F Brady; Jon M Fukuto; Arthur K Cho
Comparative studies of N-hydroxylation and N-demethylation by microsomal cytochrome P-450.
Chemical research in toxicology 1991;4(1):70-6.
1990: Louis J Ignarro; P A Bush; Georgette M Buga; K S Wood; Jon M Fukuto; Jacob Rajfer
Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle.
Biochemical and biophysical research communications 1990;170(2):843-50.
1990: M E Gold; K S Wood; R E Byrns; Jon M Fukuto; Louis J Ignarro
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4430-4.
1990: Jon M Fukuto; K S Wood; R E Byrns; Louis J Ignarro
NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation.
Biochemical and biophysical research communications 1990;168(2):458-65.
1986: Jon M Fukuto; J F Brady; J N Burstyn; R B VanAtta; J S Valentine; Arthur K Cho
Direct formation of complexes between cytochrome P-450 and nitrosoarenes.
Biochemistry 1986;25(9):2714-9.
1985: Jon M Fukuto; E W Di Stefano; J N Burstyn; J S Valentine; Arthur K Cho
Mechanism of oxidation of N-hydroxyphentermine by superoxide.
Biochemistry 1985;24(15):4161-7.