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Yoshihiko Funae

Research Profile

Chemicals & Drugs

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Masayuki Shiota; Masako Tanaka; Yoshihiko Funae; Yuko Hikita; Yasukatsu Izumi; Yukiko Kawamoto; Hiromi Kusakabe; Katsuyuki Miura; Takafumi Nakao; Hiroshi Iwao
Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2.
Tomoka Wachi; Noriyuki Yoshida; Yoshihiko Funae; Gregory G Germino; Shinji Hirotsune; Munehisa Ueno; Nobuhiro Deguchi
Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice.
Ami Oguro; Koichi Sakamoto; Yoshihiko Funae; Susumu Imaoka
Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.

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2012: Masayuki Shiota; Masako Tanaka; Yoshihiko Funae; Yuko Hikita; Yasukatsu Izumi; Yukiko Kawamoto; Hiromi Kusakabe; Katsuyuki Miura; Takafumi Nakao; Hiroshi Iwao
Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2.
Journal of cellular and molecular medicine 2012;16(9):2001-9.
2012: Tomoka Wachi; Noriyuki Yoshida; Yoshihiko Funae; Gregory G Germino; Shinji Hirotsune; Munehisa Ueno; Nobuhiro Deguchi
Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1(-/-) mice.
Biochemical and biophysical research communications 2012;425(2):212-8.
2011: Ami Oguro; Koichi Sakamoto; Yoshihiko Funae; Susumu Imaoka
Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.
Drug metabolism and pharmacokinetics 2011;26(4):407-15.
2010: Atsushi Nakahira; Yukiko Minamiyama; Shigekazu Takemura; Hidekazu Hirai; Yasuyuki Sasaki; Shigeru Okada; Yoshihiko Funae; Shigefumi Suehiro
Coadministration of carvedilol attenuates nitrate tolerance by preventing cytochrome p450 depletion.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(8):1711-7.
2010: Masayuki Shiota; Hiromi Kusakabe; Yasukatsu Izumi; Yuko Hikita; Takafumi Nakao; Yoshihiko Funae; Katsuyuki Miura; Hiroshi Iwao
Heat shock cognate protein 70 is essential for Akt signaling in endothelial function.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):491-7.
2010: Ryo Komurasaki; Susumu Imaoka; Naomichi Tada; Kazushi Okada; Shuhei Nishiguchi; Yoshihiko Funae
LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6.
Drug metabolism and pharmacokinetics 2010;25(1):84-92.
2009: Kazushi Okada; Shoko Hashimoto; Yoshihiko Funae; Susumu Imaoka
Hydroxylated polychlorinated biphenyls (PCBs) interact with protein disulfide isomerase and inhibit its activity.
Chemical research in toxicology 2009;22(5):899-904.
2009: Shizuo Narimatsu; Daichi Kazamori; Kazufumi Masuda; Takashi Katsu; Yoshihiko Funae; Shinsaku Naito; Hironori Nakura; Shigeru Yamano; Nobumitsu Hanioka
The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol.
Biochemical pharmacology 2009;77(5):920-31.
2008: Taisuke Baba; Masuhiro Nishimura; Yoshikazu Kuwahara; Nobuhiko Ueda; Shinsaku Naitoh; Makoto Kume; Yuzo Yamamoto; Jun Fujita; Yoshihiko Funae; Manabu Fukumoto
Analysis of gene and protein expression of cytochrome P450 and stress-associated molecules in rat liver after spaceflight.
Pathology international 2008;58(9):589-95.
2008: Sachiko Suzuki; Ami Oguro; Mayuko Osada-Oka; Yoshihiko Funae; Susumu Imaoka
Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells.
Journal of pharmacological sciences 2008;108(1):79-88.
2008: Shizuo Narimatsu; Kimio Kiryu; Rei Yonemoto; Manabu Yoshino; Mitsuko Kobatake; Daichi Kazamori; Saori Hagino; Kazufumi Masuda; Takashi Katsu; Masato Asanuma; Takuya Kumamoto; Tsutomu Ishikawa; Yoshihiko Funae; Shigeru Yamano; Nobumitsu Hanioka; Shinsaku Naito
The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2.
Chemico-biological interactions 2008;172(1):11-21.
2008: Toshiro Niwa; Kazushi Okada; Toyoko Hiroi; Susumu Imaoka; Shizuo Narimatsu; Yoshihiko Funae
Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain.
Biological & pharmaceutical bulletin 2008;31(3):348-51.
2008: Shigekazu Takemura; Yukiko Minamiyama; Shinya Toyokuni; Susumu Imaoka; Seikan Hai; Shoji Kubo; Kazuhiro Hirohashi; Yoshihiko Funae; Shigeru Okada
Overexpression of CYP3A aggravates endotoxin-induced liver injury in hypophysectomized female rats.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(1):70-8.
2007: Kazushi Okada; Susumu Imaoka; Shoko Hashimoto; Toyoko Hiroi; Yoshihiko Funae
Over-expression of protein disulfide isomerase reduces the release of growth hormone induced by bisphenol A and/or T3.
Molecular and cellular endocrinology 2007;278(1-2):44-51.
2007: Tsutomu Shimada; Norie Murayama; Kazushi Okada; Yoshihiko Funae; Hiroshi Yamazaki; F Peter Guengerich
Different mechanisms for inhibition of human cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic inhibitors.
Chemical research in toxicology 2007;20(3):489-96.
2007: Yukiko Minamiyama; Shigekazu Takemura; Susumu Imaoka; Yoshihiko Funae; Shigeru Okada
Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates.
Drug metabolism and pharmacokinetics 2007;22(1):15-9.
2007: Yukiko Minamiyama; Shigekazu Takemura; Seikan Hai; Shigefumi Suehiro; Shigeru Okada; Yoshihiko Funae
Nicorandil elevates tissue cGMP levels in a nitric-oxide-independent manner.
Journal of pharmacological sciences 2007;103(1):33-9.
2006: Miki Nakajima; Masahiro Itoh; Haruko Sakai; Tatsuki Fukami; Miki Katoh; Hiroshi Yamazaki; Fred F Kadlubar; Susumu Imaoka; Yoshihiko Funae; Tsuyoshi Yokoi
CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.
International journal of cancer. Journal international du cancer 2006;119(11):2520-6.
2006: Rawiwan Puatanachokchai; Keiichirou Morimura; Hideki Wanibuchi; Mayuko Oka; Anna Kakehashi; Fukui Mitsuru; Shuji Yamaguchi; Yoshihiko Funae; Shoji Fukushima
Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes.
Cancer letters 2006;240(1):102-13.
2006: Shigekazu Takemura; Yukiko Minamiyama; Kazuhiro Hirohashi; Shoji Kubo; Yoshihiko Funae; Hiroaki Kinoshita
Recovery of hepatic function determined by cytochrome P450-dependent drug metabolism lags after compensatory hepatic volume changes after portal vein ligation in rats.
The Journal of surgical research 2006;134(2):285-91.
2006: Toyoko Hiroi; Kazushi Okada; Susumu Imaoka; Mayuko Osada; Yoshihiko Funae
Bisphenol A binds to protein disulfide isomerase and inhibits its enzymatic and hormone-binding activities.
Endocrinology 2006;147(6):2773-80.
2005: Kazushi Okada; Toyoko Hiroi; Susumu Imaoka; Yoshihiko Funae
Inhibitory effects of environmental chemicals on protein disulfide isomerase in vitro.
Osaka city medical journal 2005;51(2):51-63.
2005: Susumu Imaoka; Takanori Hashizume; Yoshihiko Funae
Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs.
Drug metabolism and pharmacokinetics 2005;20(6):478-84.
2005: Susumu Imaoka; Noriko Obata; Toyoko Hiroi; Mayuko Osada-Oka; Rie Hara; Shuhei Nishiguchi; Yoshihiko Funae
A new epitope of CYP2D6 recognized by liver kidney microsomal autoantibody from japanese patients with autoimmune hepatitis.
Biological & pharmaceutical bulletin 2005;28(12):2240-3.
2005: Nagako Tanaka; Raku Shinkyo; Toshiyuki Sakaki; Masahiko Kasamastu; Susumu Imaoka; Yoshihiko Funae; Hiroshi Yokota
Cytochrome P450 2E polymorphism in feline liver.
Biochimica et biophysica acta 2005;1726(2):194-205.
2005: Masahiko Kushida; Hideki Wanibuchi; Keiichirou Morimura; Anna Kakehashi; Jin Seok Kang; Rawiwan Puatanachokchai; Min Wei; Yoshihiko Funae; Shoji Fukushima
Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold.
Cancer science 2005;96(11):747-57.
2005: Noriaki Sakai; Konomu Saito; Hyung-Sub Kim; Akio Kazusaka; Mayumi Ishizuka; Yoshihiko Funae; Shoichi Fujita
Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(11):1657-60.
2005: Masafumi Miyazaki; Hiroshi Yamazaki; Hijiri Takeuchi; Kousuke Saoo; Masanao Yokohira; Ken-ichi Masumura; Takehiko Nohmi; Yoshihiko Funae; Katsumi Imaida; Tetsuya Kamataki
Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
Carcinogenesis 2005;26(11):1947-55.
2005: Takashi Isobe; Hiroyuki Hichiya; Nobumitsu Hanioka; Shigeo Yamamoto; Sumio Shinoda; Yoshihiko Funae; Tetsuo Satoh; Shigeru Yamano; Shizuo Narimatsu
Different effects of desipramine on bufuralol 1''-hydroxylation by rat and human CYP2D enzymes.
Biological & pharmaceutical bulletin 2005;28(4):634-40.
2004: Shizuo Narimatsu; Kazuo Imoto; Takashi Isobe; Kimio Kiryu; Shinsaku Naito; Hiroyuki Hichiya; Yoshihiko Funae; Nobumitsu Hanioka; Shigeo Yamamoto
The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.
Biochemical and biophysical research communications 2004;324(2):627-33.
2004: Toshiro Niwa; Toyoko Hiroi; Daisuke Tsuzuki; Shigeo Yamamoto; Shizuo Narimatsu; Tsuyoshi Fukuda; Junichi Azuma; Yoshihiko Funae
Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6.
Brain research. Molecular brain research 2004;129(1-2):117-23.
2004: Mayuko Osada; Susumu Imaoka; Yoshihiko Funae
Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein.
FEBS letters 2004;575(1-3):59-63.
2004: Yukiko Minamiyama; Shigekazu Takemura; Shinya Toyokuni; Susumu Imaoka; Yoshihiko Funae; Kazuhiro Hirohashi; Toshikazu Yoshikawa; Shigeru Okada
CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats.
Free radical biology & medicine 2004;37(5):703-12.
2004: Tomoko Kubo; Nobuhiro Maezawa; Mayuko Osada; Shigeo Katsumura; Yoshihiko Funae; Susumu Imaoka
Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha.
Biochemical and biophysical research communications 2004;318(4):1006-11.
2004: Motonobu Furukawa; Masuhiro Nishimura; Daisuke Ogino; Ryoji Chiba; Iwao Ikai; Nobuhiko Ueda; Shinsaku Naito; Shunji Kuribayashi; Mohsen A Moustafa; Takafumi Uchida; Hideki Sawada; Tetsuya Kamataki; Yoshihiko Funae; Manabu Fukumoto
Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver.
Cancer science 2004;95(6):520-9.
2004: Yukiko Minamiyama; Shigekazu Takemura; Keiichi Yamasaki; Seikan Hai; Kazuhiro Hirohashi; Yoshihiko Funae; Shigeru Okada
Continuous administration of organic nitrate decreases hepatic cytochrome P450.
The Journal of pharmacology and experimental therapeutics 2004;308(2):729-35.
2004: Wataru Kishimoto; Toyoko Hiroi; Masakazu Shiraishi; Mayuko Osada; Susumu Imaoka; Shiro Kominami; Takashi Igarashi; Yoshihiko Funae
Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain.
Endocrinology 2004;145(2):699-705.
2004: Susumu Imaoka; Mayuko Osada; Yukiko Minamiyama; Tokihito Yukimura; Shinya Toyokuni; Shigekazu Takemura; Toyoko Hiroi; Yoshihiko Funae
Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation.
Cancer letters 2004;203(2):117-25.
2003: Takashi Yoneda; Toyoko Hiroi; Mayuko Osada; Akira Asada; Yoshihiko Funae
Non-genomic modulation of dopamine release by bisphenol-A in PC12 cells.
Journal of neurochemistry 2003;87(6):1499-508.
2003: Anna Kakehashi; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Jun Shen; Susumu Imaoka; Yoshihiko Funae; Shoji Fukushima
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.
Carcinogenesis 2003;24(8):1389-99.
2003: Tadaaki Hanatani; Tsuyoshi Fukuda; Sachi Onishi; Yoshihiko Funae; Junichi Azuma
No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3.
European journal of clinical pharmacology 2003;59(3):233-5.
2003: Dai Mizuno; Yoshiki Takahashi; Toyoko Hiroi; Susumu Imaoka; Tetsuya Kamataki; Yoshihiko Funae
A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.
Biochimica et biophysica acta 2003;1627(2-3):121-8.
2003: Dai Mizuno; Toyoko Hiroi; Pohshing Ng; Wataru Kishimoto; Susumu Imaoka; Yoshihiko Funae
Regulation of CYP2D expression in rat brain by toluene.
Osaka city medical journal 2003;49(1):49-56.
2003: Kazuhide Ayajiki; Hideyuki Fujioka; Noboru Toda; Shigeru Okada; Yukiko Minamiyama; Susumu Imaoka; Yoshihiko Funae; Shuji Watanabe; Akio Nakamura; Tomio Okamura
Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(3):237-43.
2003: Jennifer Venhorst; Antonius Marinus ter Laak; Jan N M Commandeur; Yoshihiko Funae; Toyoko Hiroi; Nico P E Vermeulen
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
Journal of medicinal chemistry 2003;46(1):74-86.
2003: Yoshihiko Funae; Wataru Kishimoto; Toshio Cho; Toshiro Niwa; Toyoko Hiroi
CYP2D in the brain.
Drug metabolism and pharmacokinetics 2003;18(6):337-49.
2003: Poh-Sing Ng; Susumu Imaoka; Toyoko Hiroi; Mayuko Osada; Toshio Niwa; Tetsuya Kamataki; Yoshihiko Funae
Production of inhibitory polyclonal antibodies against cytochrome P450s.
Drug metabolism and pharmacokinetics 2003;18(3):163-72.
2002: Toyoko Hiroi; Toshio Chow; Susumu Imaoka; Yoshihiko Funae
Catalytic specificity of CYP2D isoforms in rat and human.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(9):970-6.
2002: Takayuki Nishikawa; Hideki Wanibuchi; Motome Ogawa; Anna Kakehashi; Keiichirou Morimura; Toyoko Hiroi; Yoshihiko Funae; Hideki Kishida; Dai Nakae; Shoji Fukushima
Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism.
International journal of cancer. Journal international du cancer 2002;100(2):136-9.
2002: Mayuko Osada; Susumu Imaoka; Toshikado Sugimoto; Toyoko Hiroi; Yoshihiko Funae
NADPH-cytochrome P-450 reductase in the plasma membrane modulates the activation of hypoxia-inducible factor 1.
The Journal of biological chemistry 2002;277(26):23367-73.
2002: Tokuo Sukata; Satoshi Uwagawa; Keisuke Ozaki; Motome Ogawa; Takayuki Nishikawa; Syuji Iwai; Anna Kakehashi; Hideki Wanibuchi; Susumu Imaoka; Yoshihiko Funae; Yasuyoshi Okuno; Shoji Fukushima
Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effect.
International journal of cancer. Journal international du cancer 2002;99(1):112-8.
2002: Anna Kakehashi; Hideki Wanibuchi; Susumu Imaoka; Motome Ogawa; Chikayoshi Masuda; Keiichirou Morimura; Yoshihiko Funae; Shoji Fukushima
Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.
Carcinogenesis 2002;23(2):341-9.
2002: Kazuhito Watanabe; Tamihide Matsunaga; Toshiyuki Kimura; Tatsuya Funahashi; Yoshihiko Funae; Tohru Ohshima; Ikuo Yamamoto
Major cytochrome P450 enzymes responsible for microsomal aldehyde oxygenation of 11-oxo-Delta8-tetrahydrocannabinol and 9-anthraldehyde in human liver.
Drug metabolism and pharmacokinetics 2002;17(6):516-21.
2002: Takahiro Kamada; Toshio Chow; Toyoko Hiroi; Susumu Imaoka; Kazuhiko Morimoto; Hironori Ohde; Yoshihiko Funae
Metabolism of selegiline hydrochloride, a selective monoamine b-type inhibitor, in human liver microsomes.
Drug metabolism and pharmacokinetics 2002;17(3):199-206.
2002: Yoshitaka Yamaguchi; Shirou Kirita; Hiroshi Hasegawa; Junko Aoyama; Susumu Imaoka; Sachiko Minamiyama; Yoshihiko Funae; Takahiko Baba; Takashi Matsubara
Contribution of CYP4A8 to the formation of 20-hydroxyeicosatetraenoic acid from arachidonic acid in rat kidney.
Drug metabolism and pharmacokinetics 2002;17(2):109-16.
2002: Yoshitane Kojima; Yoshikawa Yutaka; Eriko Ueda; Mayuko Kondo; Saeko Takahashi; Takefumi Matsukura; Hiromu Sakurai; Toyoko Hiroi; Susumu Imaoka; Yoshihiko Funae
Blood glucose lowering and toxicological effects of zinc (II) complexes with maltol, threonine, and picolinic acid.
Research communications in molecular pathology and pharmacology 2002;112(1-4):91-104.
2002: Takanori Hashizume; Susumu Imaoka; Masashi Mise; Yoshiaki Terauchi; Toshihiko Fujii; Hisashi Miyazaki; Tetsuya Kamataki; Yoshihiko Funae
Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes.
The Journal of pharmacology and experimental therapeutics 2002;300(1):298-304.
2001: Yukiko Minamiyama; Susumu Imaoka; Shigekazu Takemura; S Okada; Masayasu Inoue; Yoshihiko Funae
Escape from tolerance of organic nitrate by induction of cytochrome P450.
Free radical biology & medicine 2001;31(11):1498-508.
2001: Daisuke Tsuzuki; Chie Takemi; Shigeo Yamamoto; Keietsu Tamagake; S Imaoka; Yoshihiko Funae; Hiroyuki Kataoka; Sumio Shinoda; Shizuo Narimatsu
Functional evaluation of cytochrome P450 2D6 with Gly42Arg substitution expressed in Saccharomyces cerevisiae.
Pharmacogenetics 2001;11(8):709-18.
2001: Toyoko Hiroi; Wataru Kishimoto; Toshio Chow; Susumu Imaoka; Takashi Igarashi; Yoshihiko Funae
Progesterone oxidation by cytochrome P450 2D isoforms in the brain.
Endocrinology 2001;142(9):3901-8.
2001: Susumu Imaoka; K Hayashi; Toyoko Hiroi; Y Yabusaki; Tetsuya Kamataki; Yoshihiko Funae
A transgenic mouse expressing human CYP4B1 in the liver.
Biochemical and biophysical research communications 2001;284(3):757-62.
2001: Takanori Hashizume; Masashi Mise; Satoshi Matsumoto; Yoshiaki Terauchi; Toshihiko Fujii; Susumu Imaoka; Yoshihiko Funae; Tetsuya Kamataki; Hisashi Miyazaki
A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(6):798-805.
2001: Susumu Imaoka; Y Yoneda; T Sugimoto; Shinichi Ikemoto; Toyoko Hiroi; K Yamamoto; T Nakatani; Yoshihiko Funae
Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction.
Cancer letters 2001;166(2):119-23.
2001: Yutaka Oda; Naoya Hamaoka; Toyoko Hiroi; Susumu Imaoka; Ichiro Hase; Kazuo Tanaka; Yoshihiko Funae; T Ishizaki; Akira Asada
Involvement of human liver cytochrome P4502B6 in the metabolism of propofol.
British journal of clinical pharmacology 2001;51(3):281-5.
2001: Chikayoshi Masuda; Hideki Wanibuchi; K Otori; Min Wei; Shigeo Yamamoto; Toyoko Hiroi; Susumu Imaoka; Yoshihiko Funae; Shoji Fukushima
Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats.
Cancer letters 2001;163(2):179-85.
2001: Takanori Hashizume; Susumu Imaoka; Toyoko Hiroi; Yoshiaki Terauchi; Toshihiko Fujii; Hisashi Miyazaki; Tetsuya Kamataki; Yoshihiko Funae
cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine.
Biochemical and biophysical research communications 2001;280(4):1135-41.
2001: T Hanatani; Tsuyoshi Fukuda; M Ikeda; S Imaoka; Toyoko Hiroi; Yoshihiko Funae; Junichi Azuma
CYP2C9*3 influences the metabolism and the drug-interaction of candesartan in vitro.
The pharmacogenomics journal 2001;1(4):288-92.
2000: Susumu Imaoka; Y Yoneda; T Sugimoto; Toyoko Hiroi; K Yamamoto; T Nakatani; Yoshihiko Funae
CYP4B1 is a possible risk factor for bladder cancer in humans.
Biochemical and biophysical research communications 2000;277(3):776-80.
2000: Tsuyoshi Fukuda; Yuko Nishida; S Imaoka; Toyoko Hiroi; Masakazu Naohara; Yoshihiko Funae; Junichi Azuma
The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6.
Archives of biochemistry and biophysics 2000;380(2):303-8.
2000: T Nakamoto; Ichiro Hase; Susumu Imaoka; Toyoko Hiroi; Yutaka Oda; Akira Asada; Yoshihiko Funae
Quantitative RT-PCR for CYP3A4 mRNA in human peripheral lymphocytes: induction of CYP3A4 in lymphocytes and in liver by rifampicin.
Pharmacogenetics 2000;10(6):571-5.
2000: Mitsuaki Kitano; Hideki Wanibuchi; Hiroe Kikuzaki; Nobuji Nakatani; Susumu Imaoka; Yoshihiko Funae; Shuji Hayashi; Shoji Fukushima
Chemopreventive effects of coumaperine from pepper on the initiation stage of chemical hepatocarcinogenesis in the rat.
Japanese journal of cancer research : Gann 2000;91(7):674-80.
2000: Ichiro Hase; Susumu Imaoka; Yutaka Oda; Toyoko Hiroi; T Nakamoto; Akira Asada; Yoshihiko Funae
Area under the plasma concentration-time curve of inorganic fluoride following sevoflurane anesthesia correlates with CYP2E1 mRNA level in mononuclear cells.
Anesthesiology 2000;92(6):1661-6.
2000: Susumu Imaoka; Yoshihiko Funae
[Arachidonic acid metabolites (HETEs and EETs) produced by cytochrome P450s].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():107-12.
2000: N Ishiguro; C Senda; Wataru Kishimoto; K Sakai; Yoshihiko Funae; Takashi Igarashi
Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(1):71-80.
1999: Kazuhide Ayajiki; Tomio Okamura; Hideyuki Fujioka; S Imaoka; Yoshihiko Funae; Noboru Toda
Involvement of CYP3A-derived arachidonic acid metabolite(s) in responses to endothelium-derived K+ channel opening substance in monkey lingual artery.
British journal of pharmacology 1999;128(3):802-8.
1999: Toshio Chow; Toyoko Hiroi; Susumu Imaoka; K Chiba; Yoshihiko Funae
Isoform-selective metabolism of mianserin by cytochrome P-450 2D.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(10):1200-4.
1999: Toshio Ichihara; Hideki Wanibuchi; T Taniyama; Y Okai; Yoshihisa Yano; Shuzo Otani; Susumu Imaoka; Yoshihiko Funae; Shoji Fukushima
Inhibition of liver glutathione S-transferase placental form-positive foci development in the rat hepatocarcinogenesis by Porphyra tenera (Asakusa-nori).
Cancer letters 1999;141(1-2):211-8.
1999: Yukiko Minamiyama; Shigekazu Takemura; T Akiyama; S Imaoka; M Inoue; Yoshihiko Funae; S Okada
Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels.
FEBS letters 1999;452(3):165-9.
1999: Shigekazu Takemura; Yukiko Minamiyama; Susumu Imaoka; Yoshihiko Funae; Kazuhiro Hirohashi; Masayasu Inoue; Hiroaki Kinoshita
Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
Journal of hepatology 1999;30(6):1035-44.
1999: Toshio Chow; Susumu Imaoka; Toyoko Hiroi; Yoshihiko Funae
Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):188-92.
1998: Toyoko Hiroi; Susumu Imaoka; Yoshihiko Funae
Dopamine formation from tyramine by CYP2D6.
Biochemical and biophysical research communications 1998;249(3):838-43.
1998: Mitsuaki Kitano; Toshio Ichihara; T Matsuda; Hideki Wanibuchi; S Tamano; A Hagiwara; Susumu Imaoka; Yoshihiko Funae; Tomoyuki Shirai; Shoji Fukushima
Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.
Carcinogenesis 1998;19(8):1475-80.
1998: Yukiko Minamiyama; Shigekazu Takemura; Susumu Imaoka; Yoshihiko Funae; Masayasu Inoue
[Inhibition of cytochrome P450 by nitric oxide].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112(1):33-41.
1998: Susumu Imaoka; Yoshihiko Funae
[The physiological role of P450-derived arachidonic acid metabolites].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1998;112(1):23-31.
1998: Susumu Imaoka; J Wan; Toshio Chow; Toyoko Hiroi; R Eyanagi; H Shigematsu; Yoshihiko Funae
Cloning and characterization of the CYP2D1-binding protein, retinol dehydrogenase.
Archives of biochemistry and biophysics 1998;353(2):331-6.
1998: Toyoko Hiroi; Susumu Imaoka; Toshio Chow; Yoshihiko Funae
Tissue distributions of CYP2D1, 2D2, 2D3 and 2D4 mRNA in rats detected by RT-PCR.
Biochimica et biophysica acta 1998;1380(3):305-12.
1998: M Nakamura; Susumu Imaoka; E Tanaka; S Misawa; Yoshihiko Funae
cis-Diamminedichloroplatinum induces peroxisomes as well as CYP4A1 in rat kidney.
Research communications in molecular pathology and pharmacology 1998;99(1):23-32.
1997: J Wan; Susumu Imaoka; Toshio Chow; Toyoko Hiroi; Y Yabusaki; Yoshihiko Funae
Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity.
Archives of biochemistry and biophysics 1997;348(2):383-90.
1997: Wataru Kishimoto; Toyoko Hiroi; K Sakai; Yoshihiko Funae; Takashi Igarashi
Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine.
Research communications in molecular pathology and pharmacology 1997;98(3):273-92.
1997: Yukiko Minamiyama; Shigekazu Takemura; Susumu Imaoka; Yoshihiko Funae; Y Tanimoto; Masayasu Inoue
Irreversible inhibition of cytochrome P450 by nitric oxide.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1479-85.
1997: Susumu Imaoka; Y Yoneda; T Matsuda; M Degawa; S Fukushima; Yoshihiko Funae
Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa.
Biochemical pharmacology 1997;54(6):677-83.
1997: Toyoko Hiroi; Susumu Imaoka; Toshio Chow; Y Yabusaki; Yoshihiko Funae
Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6.
Biochemical pharmacology 1997;53(12):1937-9.
1997: T Nakamoto; Y Oda; Susumu Imaoka; Yoshihiko Funae; M Fujimori
Effect of phenobarbital on the pharmacokinetics of lidocaine, monoethylglycinexylidide and 3-hydroxylidocaine in the rat: correlation with P450 isoform levels.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(3):296-300.
1997: Y Maeda; K Morita; T Tasaki; Yoshihiko Funae; S Imaoka; Akio Kazusaka; Shoichi Fujita
Strain differences in age-associated change in testosterone 6β-hydroxylation in Wistar and Dark Agouti rats.
Environmental toxicology and pharmacology 1997;3(1):1-6.
1997: S Kunitoh; Susumu Imaoka; Toyoko Hiroi; Y Yabusaki; T Monna; Yoshihiko Funae
Acetaldehyde as well as ethanol is metabolized by human CYP2E1.
The Journal of pharmacology and experimental therapeutics 1997;280(2):527-32.
1997: T Yamada; Susumu Imaoka; Norifumi Kawada; Shuichi Seki; Tetsuo Kuroki; Keiko Kobayashi; T Monna; Yoshihiko Funae
Expression of cytochrome P450 isoforms in rat hepatic stellate cells.
Life sciences 1997;61(2):171-9.
1997: Y Tamura; S Imaoka; Munekazu Gemba; Yoshihiko Funae
Effects of ischemia-reperfusion on individual cytochrome P450 isoforms in the rat kidney.
Life sciences 1997;60(2):143-9.
1996: Toshio Chow; Susumu Imaoka; Toyoko Hiroi; Yoshihiko Funae
Reductive metabolism of halothane by cytochrome P450 isoforms in rats and humans.
Research communications in molecular pathology and pharmacology 1996;93(3):363-74.
1996: H Asai; Susumu Imaoka; T Kuroki; T Monna; Yoshihiko Funae
Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s.
The Journal of pharmacology and experimental therapeutics 1996;277(2):1004-9.
1996: Susumu Imaoka; T Yamada; Toyoko Hiroi; K Hayashi; T Sakaki; Y Yabusaki; Yoshihiko Funae
Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat.
Biochemical pharmacology 1996;51(8):1041-50.
1996: S Kunitoh; H Asai; Susumu Imaoka; Yoshihiko Funae; T Monna
Metabolism of acetaldehyde to acetate by rat hepatic P-450s: presence of different metabolic pathway from acetaldehyde dehydrogenase system.
Alcoholism, clinical and experimental research 1996;20(1 Suppl):22A-24A.
1995: T Matsuda; Susumu Imaoka; Yoshihiko Funae; K Otori; Shoji Fukushima
Induction of CYP isoenzymes in various organs of rats by 3-methylcholanthrene or beta-naphthoflavone.
Cancer letters 1995;97(2):137-43.
1995: Susumu Imaoka; Toyoko Hiroi; Y Tamura; H Yamazaki; T Shimada; M Komori; M Degawa; Yoshihiko Funae
Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1.
Archives of biochemistry and biophysics 1995;321(1):255-62.
1995: Toyoko Hiroi; Y Miyazaki; Y Kobayashi; Susumu Imaoka; Yoshihiko Funae
Induction of hepatic P450s in rat by essential wood and leaf oils.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(5):457-67.
1995: Toyoko Hiroi; N Ohishi; Susumu Imaoka; Y Yabusaki; H Fukui; Yoshihiko Funae
Mepyramine, a histamine H1 receptor antagonist, inhibits the metabolic activity of rat and human P450 2D forms.
The Journal of pharmacology and experimental therapeutics 1995;272(2):939-44.
1994: N Ohishi; Susumu Imaoka; Yoshihiko Funae
Changes in content of P450 isozymes in hepatic and renal microsomes of the male rat treated with cis-diamminedichloroplatinum.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(9):873-80.
1994: K Tanaka; Yutaka Oda; Akira Asada; M Fujimori; Yoshihiko Funae
Metabolism of lidocaine by rat pulmonary cytochrome P450.
Biochemical pharmacology 1994;47(6):1061-6.
1993: Susumu Imaoka; M Nakamura; T Ishizaki; N Shimojo; N Ohishi; S Fujii; Yoshihiko Funae
Regulation of renal cytochrome P450s by thyroid hormone in diabetic rats.
Biochemical pharmacology 1993;46(12):2197-200.
1993: N Ohishi; Susumu Imaoka; T Suzuki; Yoshihiko Funae
Characterization of two P-450 isozymes placed in the rat CYP2D subfamily.
Biochimica et biophysica acta 1993;1158(3):227-36.
1993: N Shimojo; T Ishizaki; Susumu Imaoka; Yoshihiko Funae; S Fujii; K Okuda
Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes.
Biochemical pharmacology 1993;46(4):621-7.
1993: Susumu Imaoka; T Sugiyama; N Taniguchi; Yoshihiko Funae
Expression of cytochrome P450 in LEC rats during the development of hereditary hepatitis and hepatoma.
Carcinogenesis 1993;14(1):117-21.
1993: S Kunitoh; T Tanaka; Susumu Imaoka; Yoshihiko Funae; Y Monna
Contribution of cytochrome P450s to MEOS (microsomal ethanol-oxidizing system): a specific and sensitive assay of MEOS activity by HPLC with fluorescence labeling.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1993;1B():63-8.
1992: Susumu Imaoka; Y Yamazoe; R Kato; Yoshihiko Funae
Hormonal regulation of rat renal cytochrome P450s by androgen and the pituitary.
Archives of biochemistry and biophysics 1992;299(1):179-84.
1992: Susumu Imaoka; Y Imai; T Shimada; Yoshihiko Funae
Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity.
Biochemistry 1992;31(26):6063-9.
1992: Shinichi Ikemoto; Susumu Imaoka; N Hayahara; M Maekawa; Yoshihiko Funae
Expression of hepatic microsomal cytochrome P450s as altered by uremia.
Biochemical pharmacology 1992;43(11):2407-12.
1991: Susumu Imaoka; Yoshihiko Funae
Induction of cytochrome P450 isozymes in rat liver by methyl n-alkyl ketones and n-alkylbenzenes. Effects of hydrophobicity of inducers on inducibility of cytochrome P450.
Biochemical pharmacology 1991;42 Suppl():S143-50.
1991: Susumu Imaoka; S Fujita; Yoshihiko Funae
Age-dependent expression of cytochrome P-450s in rat liver.
Biochimica et biophysica acta 1991;1097(3):187-92.
1991: Susumu Imaoka; Yoshihiko Funae
Hepatic and renal cytochrome P-450s in spontaneously hypertensive rats.
Biochimica et biophysica acta 1991;1074(1):209-13.
1990: Susumu Imaoka; K Enomoto; Y Oda; A Asada; M Fujimori; T Shimada; S Fujita; F P Guengerich; Yoshihiko Funae
Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1385-91.
1990: Susumu Imaoka; Y Yamaguchi; Yoshihiko Funae
Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation.
Biochimica et biophysica acta 1990;1036(1):18-23.
1990: Susumu Imaoka; Yoshihiko Funae
Purification and characterization of rat pulmonary cytochrome P-450.
Journal of biochemistry 1990;108(1):33-6.
1990: S Tanaka; Susumu Imaoka; Emi Kusunose; Masamichi Kusunose; M Maekawa; Yoshihiko Funae
Omega- and (omega-1)-hydroxylation of arachidonic acid, lauric acid and prostaglandin A1 by multiple forms of cytochrome P-450 purified from rat hepatic microsomes.
Biochimica et biophysica acta 1990;1043(2):177-81.
1990: Susumu Imaoka; Y Terano; Yoshihiko Funae
Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation.
Archives of biochemistry and biophysics 1990;278(1):168-78.
1990: Susumu Imaoka; K Nagashima; Yoshihiko Funae
Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450.
Archives of biochemistry and biophysics 1990;276(2):473-80.
1989: Yutaka Oda; Susumu Imaoka; Y Nakahira; Akira Asada; M Fujimori; S Fujita; Yoshihiko Funae
Metabolism of lidocaine by purified rat liver microsomal cytochrome P-450 isozymes.
Biochemical pharmacology 1989;38(24):4439-44.
1989: Yasushi Kikuta; Emi Kusunose; S Matsubara; Yoshihiko Funae; Susumu Imaoka; I Kubota; Masamichi Kusunose
Purification and characterization of hepatic microsomal prostaglandin omega-hydroxylase cytochrome P-450 from pregnant rabbits.
Journal of biochemistry 1989;106(3):468-73.
1989: Susumu Imaoka; Y Terano; Yoshihiko Funae
Expression of four phenobarbital-inducible cytochrome P-450s in liver, kidney, and lung of rats.
Journal of biochemistry 1989;105(6):939-45.
1989: Susumu Imaoka; S Tanaka; Yoshihiko Funae
Omega- and (omega-1)-hydroxylation of lauric acid and arachidonic acid by rat renal cytochrome P-450.
Biochemistry international 1989;18(4):731-40.
1988: Susumu Imaoka; Y Terano; Yoshihiko Funae
Constitutive testosterone 6 beta-hydroxylase in rat liver.
Journal of biochemistry 1988;104(3):481-7.
1988: Susumu Imaoka; K Inoue; Yoshihiko Funae
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
Archives of biochemistry and biophysics 1988;265(1):159-70.
1988: Susumu Imaoka; N Shimojo; Yoshihiko Funae
Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats.
Biochemical and biophysical research communications 1988;152(2):680-7.
1988: Yoshihiko Funae; Susumu Imaoka; N Shimojo
Purification and characterization of diabetes-inducible cytochrome P-450.
Biochemistry international 1988;16(3):503-9.
1987: Susumu Imaoka; Y Terano; Yoshihiko Funae
Purification and characterization of two constitutive cytochromes P-450 (F-1 and F-2) from adult female rats: identification of P-450F-1 as the phenobarbital-inducible cytochrome P-450 in male rat liver.
Biochimica et biophysica acta 1987;916(3):358-67.
1987: Yoshihiko Funae; Susumu Imaoka
Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats.
Biochimica et biophysica acta 1987;926(3):349-58.
1987: Susumu Imaoka; T Kamataki; Yoshihiko Funae
Purification and characterization of six cytochromes P-450 from hepatic microsomes of immature female rats.
Journal of biochemistry 1987;102(4):843-51.