Tohru Funahashi

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Kamada Yoshihiro; Nakamura Tadashi; Funahashi Tohru; Ryo Miwa; Nishizawa Hitoshi; Okauchi Yukiyoshi; Fukushima Juichi; Yoshida Yuichi; Kiso Shinichi; Shimomura Iichiro; Hayashi Norio
Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction: An epidemiologic study of 3827 Japanese subjects.
Tsujimura Akira; Takada Shingo; Matsuoka Yasuhiro; Nakayama Jiro; Takao Tetsuya; Miyagawa Yasushi; Sonoda Mina; Nishizawa Hitoshi; Iwahashi Hiromi; Funahashi Tohru; Nonomura Norio; Okuyama Akihiko
Adiponectin and testosterone in patients with symptoms of late-onset hypogonadism: is there a link?
Hirata Ayumu; Maeda Norikazu; Hiuge Aki; Hibuse Toshiyuki; Fujita Koichi; Okada Takuya; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice.

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2009: Kamada Yoshihiro; Nakamura Tadashi; Funahashi Tohru; Ryo Miwa; Nishizawa Hitoshi; Okauchi Yukiyoshi; Fukushima Juichi; Yoshida Yuichi; Kiso Shinichi; Shimomura Iichiro; Hayashi Norio
Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction: An epidemiologic study of 3827 Japanese subjects.
Journal of clinical gastroenterology 2009;43(10):995-1000.
2009: Tsujimura Akira; Takada Shingo; Matsuoka Yasuhiro; Nakayama Jiro; Takao Tetsuya; Miyagawa Yasushi; Sonoda Mina; Nishizawa Hitoshi; Iwahashi Hiromi; Funahashi Tohru; Nonomura Norio; Okuyama Akihiko
Adiponectin and testosterone in patients with symptoms of late-onset hypogonadism: is there a link?
International journal of urology : official journal of the Japanese Urological Association 2009;16(10):830-5.
2009: Hirata Ayumu; Maeda Norikazu; Hiuge Aki; Hibuse Toshiyuki; Fujita Koichi; Okada Takuya; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice.
Cardiovascular research 2009;84(1):164-72.
2009: Fukushima Juichi; Kamada Yoshihiro; Matsumoto Hitoshi; Yoshida Yuichi; Ezaki Hisao; Takemura Takayo; Saji Yukiko; Igura Takumi; Tsutsui Shusaku; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro; Tamura Shinji; Kiso Shinichi; Hayashi Norio
Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(7):724-38.
2009: Hibuse Toshiyuki; Maeda Norikazu; Nakatsuji Hideaki; Tochino Yoshihiro; Fujita Koichi; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator.
Cardiovascular research 2009;83(1):34-41.
2009: Tsukamoto Osamu; Fujita Masashi; Kato Mahoto; Yamazaki Satoru; Asano Yoshihiro; Ogai Akiko; Okazaki Hidetoshi; Asai Mitsutoshi; Nagamachi Yoko; Maeda Norikazu; Shintani Yasunori; Minamino Tetsuo; Asakura Masanori; Kishimoto Ichiro; Funahashi Tohru; Tomoike Hitonobu; Kitakaze Masafumi
Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure.
Journal of the American College of Cardiology 2009;53(22):2070-7.
2009: Nakagawa Yasuhiko; Kishida Ken; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling.
Biochemical and biophysical research communications 2009;382(1):183-8.
2009: Nishida Makoto; Funahashi Tohru
[Validity of indices (BMI, Rohrer index, Broca method) for assessment of obesity]
Nippon rinsho. Japanese journal of clinical medicine 2009;67(2):301-6.
2009: Ezaki Hisao; Yoshida Yuichi; Saji Yukiko; Takemura Takayo; Fukushima Juichi; Matsumoto Hitoshi; Kamada Yoshihiro; Wada Akira; Igura Takumi; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro; Tamura Shinji; Kiso Shinichi; Hayashi Norio
Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice.
Biochemical and biophysical research communications 2009;378(1):68-72.
2009: Okauchi Yukiyoshi; Nammo Takao; Iwahashi Hiromi; Kizu Takashi; Hayashi Isao; Okita Kohei; Yamagata Kazuya; Uno Sae; Katsube Fumie; Matsuhisa Munehide; Kato Ken; Aozasa Katsuyuki; Kim Tonsok; Osuga Keigo; Nakamori Shoji; Tamaki Yasuhiro; Funahashi Tohru; Miyagawa Jun-ichiro; Shimomura Iichiro
Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
Internal medicine (Tokyo, Japan) 2009;48(12):1025-30.
2008: Okauchi Yukiyoshi; Iwahashi Hiromi; Okita Kohei; Yuan Ming; Matsuda Morihiro; Tanaka Toshiya; Miyagawa Junichiro; Funahashi Tohru; Horikawa Yukio; Shimomura Iichiro; Yamagata Kazuya
PGC-1alpha Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men.
Endocrine journal 2008;55(6):991-7.
2008: Nishihara Tamao; Baba Miyako; Matsuda Morihiro; Inoue Masahiro; Nishizawa Yasuko; Fukuhara Atsunori; Araki Hiroshi; Kihara Shinji; Funahashi Tohru; Tamura Shinji; Hayashi Norio; Iishi Hiroyasu; Shimomura Iichiro
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice.
World journal of gastroenterology : WJG 2008;14(42):6473-80.
2008: Maeda Norikazu; Funahashi Tohru; Shimomura Iichiro
Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9.
Nature clinical practice. Endocrinology & metabolism 2008;4(11):627-34.
2008: Araki H; Nishihara T; Matsuda M; Fukuhara A; Kihara S; Funahashi T; Kataoka T R; Kamada Y; Kiyohara T; Tamura S; Hayashi N; Shimomura I
Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet.
Gut 2008;57(10):1431-40.
2008: Ohara Takahiro; Kim Jiyoong; Asakura Masanori; Asanuma Hiroshi; Nakatani Satoshi; Hashimura Kazuhiko; Kanzaki Hideaki; Funahashi Tohru; Tomoike Hitonobu; Kitakaze Masafumi
Plasma adiponectin is associated with plasma brain natriuretic peptide and cardiac function in healthy subjects.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(5):825-31.
2008: Fujita Koichi; Maeda Norikazu; Sonoda Mina; Ohashi Koji; Hibuse Toshiyuki; Nishizawa Hitoshi; Nishida Makoto; Hiuge Aki; Kurata Akifumi; Kihara Shinji; Shimomura Iichiro; Funahashi Tohru
Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):863-70.
2008: Nakagawa Yasuhiko; Kishida Ken; Kihara Shinji; Sonoda Mina; Hirata Ayumu; Yasui Atsutaka; Nishizawa Hitoshi; Nakamura Tadashi; Yoshida Ryoko; Shimomura Iichiro; Funahashi Tohru
Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome.
American journal of physiology. Endocrinology and metabolism 2008;294(4):E778-84.
2008: Tokunaga Ayumi; Miura Atsuko; Okauchi Yukiyoshi; Segawa Katsumori; Fukuhara Atsunori; Okita Kohei; Takahashi Masahiko; Funahashi Tohru; Miyagawa Jun-Ichiro; Shimomura Iichiro; Yamagata Kazuya
The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects.
Endocrine journal 2008;55(1):205-12.
2008: Okada Takuya; Nishizawa Hitoshi; Kurata Akifumi; Tamba Sachiko; Sonoda Mina; Yasui Atsutaka; Kuroda Yohei; Hibuse Toshiyuki; Maeda Norikazu; Kihara Shinji; Hadama Tohru; Tobita Kazuki; Akamatsu Suguru; Maeda Kazuhisa; Shimomura Iichiro; Funahashi Tohru
URB is abundantly expressed in adipose tissue and dysregulated in obesity.
Biochemical and biophysical research communications 2008;367(2):370-6.
2008: Fukuda-Akita Etsuko; Okita Kohei; Okauchi Yukiyoshi; Ryo Miwa; Nakamura Tadashi; Funahashi Tohru; Iwahashi Hiromi; Shimomura Iichiro; Miyagawa Junichiro; Yamagata Kazuya
Impaired early insulin secretion in Japanese type 2 diabetes with metabolic syndrome.
Diabetes research and clinical practice 2008;79(3):482-9.
2008: Komura Noriyuki; Kihara Shinji; Sonoda Mina; Kumada Masahiro; Fujita Koichi; Hiuge Aki; Okada Takuya; Nakagawa Yasuhiko; Tamba Sachiko; Kuroda Yohei; Hayashi Noriyuki; Sumitsuji Satoru; Kawamoto Toshiharu; Matsumoto Satoru; Ouchi Noriyuki; Arita Yukio; Okamoto Yoshihisa; Shimomura Iichiro; Funahashi Tohru; Matsuzawa Yuji;
Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(1):23-8.
2008: Fujisawa Tomomi; Ikegami Hiroshi; Kasayama Soji; Matsuhisa Munehide; Yamasaki Yoshimitsu; Miyagawa Jun-ichiro; Funahashi Tohru; Shimomura Iichiro
Age-dependent difference in factors affecting choice of system for self-monitoring of blood glucose.
Diabetes research and clinical practice 2008;79(1):103-7.
2008: Takagi Toshiyuki; Matsuda Morihiro; Abe Manabu; Kobayashi Hironori; Fukuhara Atsunori; Komuro Ryutaro; Kihara Shinji; Caslake Muriel J; McMahon Alex; Shepherd James; Funahashi Tohru; Shimomura Iichiro
Effect of pravastatin on the development of diabetes and adiponectin production.
Atherosclerosis 2008;196(1):114-21.
2008: Tamba Sachiko; Nishizawa Hitoshi; Funahashi Tohru; Okauchi Yukiyoshi; Ogawa Tomoko; Noguchi Midori; Fujita Koichi; Ryo Miwa; Kihara Shinji; Iwahashi Hiromi; Yamagata Kazuya; Nakamura Tadashi; Shimomura Iichiro; Matsuzawa Yuji
Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men.
Internal medicine (Tokyo, Japan) 2008;47(13):1175-80.
2007: Yasui Atsutaka; Nishizawa Hitoshi; Okuno Yosuke; Morita Kentaro; Kobayashi Hironori; Kawai Kenichiro; Matsuda Morihiro; Kishida Ken; Kihara Shinji; Kamei Yasutomi; Ogawa Yoshihiro; Funahashi Tohru; Shimomura Iichiro
Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.
Biochemical and biophysical research communications 2007;364(2):358-65.
2007: Fukuhara Atsunori; Matsuda Morihiro; Nishizawa Masako; Segawa Katsumori; Tanaka Masaki; Kishimoto Kae; Matsuki Yasushi; Murakami Mirei; Ichisaka Tomoko; Murakami Hiroko; Watanabe Eijiro; Takagi Toshiyuki; Akiyoshi Megumi; Ohtsubo Tsuguteru; Kihara Shinji; Yamashita Shizuya; Makishima Makoto; Funahashi Tohru; Yamanaka Shinya; Hiramatsu Ryuji; Matsuzawa Yuji; Shimomura Iichiro
Retraction.
Science (New York, N.Y.) 2007;318(5850):565.
2007: Kamada Yoshihiro; Matsumoto Hitoshi; Tamura Shinji; Fukushima Juichi; Kiso Shinichi; Fukui Koji; Igura Takumi; Maeda Norikazu; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Shimomura Iichiro; Hayashi Norio
Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model.
Journal of hepatology 2007;47(4):556-64.
2007: Ohashi Koji; Iwatani Hirotsugu; Kihara Shinji; Nakagawa Yasuhiko; Komura Noriyuki; Fujita Koichi; Maeda Norikazu; Nishida Makoto; Katsube Fumie; Shimomura Iichiro; Ito Takahito; Funahashi Tohru
Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(9):1910-7.
2007: Okauchi Yukiyoshi; Nishizawa Hitoshi; Funahashi Tohru; Ogawa Tomoko; Noguchi Midori; Ryo Miwa; Kihara Shinji; Iwahashi Hiromi; Yamagata Kazuya; Nakamura Tadashi; Shimomura Iichiro; Matsuzawa Yuji
Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men.
Diabetes care 2007;30(9):2392-4.
2007: Hayashi Noriyuki; Funahashi Tohru
[Hyperlipidemia in endocrine disease]
Nippon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 7():417-20.
2007: Funahashi Tohru
[Definition of metabolic syndrome in Japan--concept and perspective]
Nippon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 7():84-90.
2007: Matsuhisa Munehide; Yamasaki Yoshimitsu; Emoto Masanori; Shimabukuro Michio; Ueda Shinichiro; Funahashi Tohru; Matsuzawa Yuji
A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects.
Diabetes research and clinical practice 2007;77(1):151-4.
2007: Nishida Makoto; Funahashi Tohru; Shimomura Iichiro
Pathophysiological significance of adiponectin.
Medical molecular morphology 2007;40(2):55-67.
2007: Fujita Koichi; Funahashi Tohru
[Adipocytokine]
Nippon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():191-5.
2007: Hiuge Aki; Tenenbaum Alexander; Maeda Norikazu; Benderly Michal; Kumada Masahiro; Fisman Enrique Z; Tanne David; Matas Zipora; Hibuse Toshiyuki; Fujita Koichi; Nishizawa Hitoshi; Adler Yehuda; Motro Michael; Kihara Shinji; Shimomura Iichiro; Behar Solomon; Funahashi Tohru
Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(3):635-41.
2007: Funahashi Tohru; Matsuzawa Yuji
Metabolic syndrome: clinical concept and molecular basis.
Annals of medicine 2007;39(7):482-94.
2007: Nakamura Tadashi; Okauchi Yukiyoshi; Ryo Miwa; Funahashi Tohru; Shimomura Iichiro
Clinical diagnosis of metabolic syndrome 3. Diagnostic criteria for metabolic syndrome in Japan and its clinical significance.
Internal medicine (Tokyo, Japan) 2007;46(16):1287.
2006: Ryo Miwa; Funahashi Tohru
[Global diagnosis definition of the metabolic syndrome and its management]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():463-9.
2006: Ryo Miwa; Funahashi Tohru
[Definition and characteristics of the metabolic syndrome in Japan]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():457-62.
2006: Maeda Norikazu; Funahashi Tohru
[Gene mutations of adipocytokine associated with metabolic syndrome]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():330-3.
2006: Maeda Norikazu; Hibuse Toshiyuki; Funahashi Tohru
[Aquaporin adipose (AQPap)]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():277-81.
2006: Matsuda Morihiro; Funahashi Tohru
[Adiponectin, visfatin, PAI-1]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():212-6.
2006: Maeda Norikazu; Funahashi Tohru
[Fat distribution and its regulation]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 9():188-91.
2006: Iwashima Yoshio; Horio Takeshi; Kumada Masahiro; Suzuki Yoshihiko; Kihara Shinji; Rakugi Hiromi; Kawano Yuhei; Funahashi Tohru; Ogihara Toshio
Adiponectin and renal function, and implication as a risk of cardiovascular disease.
The American journal of cardiology 2006;98(12):1603-8.
2006: Fujita Koichi; Nishizawa Hitoshi; Funahashi Tohru; Shimomura Iichiro; Shimabukuro Michio
Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(11):1437-42.
2006: Kurata A; Nishizawa H; Kihara S; Maeda N; Sonoda M; Okada T; Ohashi K; Hibuse T; Fujita K; Yasui A; Hiuge A; Kumada M; Kuriyama H; Shimomura I; Funahashi T
Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation.
Kidney international 2006;70(10):1717-24.
2006: Komura Noriyuki; Funahashi Tohru
[Obesity]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 7():705-8.
2006: Segawa Katsumori; Fukuhara Atsunori; Hosogai Naomi; Morita Kentaro; Okuno Yosuke; Tanaka Masaki; Nakagawa Yasuhiko; Kihara Shinji; Funahashi Tohru; Komuro Ryutaro; Matsuda Morihiro; Shimomura Iichiro
Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism.
Biochemical and biophysical research communications 2006;349(3):875-82.
2006: Iwashima Yoshio; Horio Takeshi; Suzuki Yoshihiko; Kihara Shinji; Rakugi Hiromi; Kangawa Kenji; Funahashi Tohru; Ogihara Toshio; Kawano Yuhei
Adiponectin and inflammatory markers in peripheral arterial occlusive disease.
Atherosclerosis 2006;188(2):384-90.
2006: Ohashi Koji; Funahashi Tohru
[Mutations and polymorphisms in adiponectin gene]
Nippon rinsho. Japanese journal of clinical medicine 2006;Suppl 3():264-8.
2006: Nishihara Tamao; Matsuda Morihiro; Araki Hiroshi; Oshima Kazuya; Kihara Shinji; Funahashi Tohru; Shimomura Iichiro
Effect of adiponectin on murine colitis induced by dextran sulfate sodium.
Gastroenterology 2006;131(3):853-61.
2006: Funahashi Tohru; Matsuzawa Yuji
Hypoadiponectinemia: a common basis for diseases associated with overnutrition.
Current atherosclerosis reports 2006;8(5):433-8.
2006: Hibuse Toshiyuki; Maeda Norikazu; Nagasawa Azumi; Funahashi Tohru
Aquaporins and glycerol metabolism.
Biochimica et biophysica acta 2006;1758(8):1004-11.
2006: Ohashi Koji; Funahashi Tohru
[Adiponectin]
Nippon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():163-7.
2006: Matsumoto Hitoshi; Tamura Shinji; Kamada Yoshihiro; Kiso Shinichi; Fukushima Juichi; Wada Akira; Maeda Norikazu; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Shimomura Iichiro; Hayashi Norio
Adiponectin deficiency exacerbates lipopolysaccharide/D-galactosamine-induced liver injury in mice.
World journal of gastroenterology : WJG 2006;12(21):3352-8.
2006: Ohashi Koji; Kihara Shinji; Ouchi Noriyuki; Kumada Masahiro; Fujita Koichi; Hiuge Aki; Hibuse Toshiyuki; Ryo Miwa; Nishizawa Hitoshi; Maeda Norikazu; Maeda Kazuhisa; Shibata Rei; Walsh Kenneth; Funahashi Tohru; Shimomura Iichiro
Adiponectin replenishment ameliorates obesity-related hypertension.
Hypertension 2006;47(6):1108-16.
2006: Ujiie Hidetoshi; Oritani Kenji; Kato Hisashi; Yokota Takafumi; Takahashi Isao; Maeda Tetsuo; Masaie Hiroaki; Ichii Michiko; Kamada Yoshihiro; Tamura Shinji; Kihara Shinji; Funahashi Tohru; Tomiyama Yoshiaki; Kanakura Yuzuru
Identification of amino-terminal region of adiponectin as a physiologically functional domain.
Journal of cellular biochemistry 2006;98(1):194-207.
2006: Okamoto Yoshihisa; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Libby Peter
Adiponectin: a key adipocytokine in metabolic syndrome.
Clinical science (London, England : 1979) 2006;110(3):267-78.
2006: Miyoshi Yasuo; Funahashi Tohru; Tanaka Sachiyo; Taguchi Tetsuya; Tamaki Yasuhiro; Shimomura Iichiro; Noguchi Shinzaburo
High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels.
International journal of cancer. Journal international du cancer 2006;118(6):1414-9.
2006: Hibuse Toshiyuki; Funahashi Tohru
[Adipocytokines and diabetes in the elderly]
Nippon rinsho. Japanese journal of clinical medicine 2006;64(1):2-5.
2006: Kato Hisashi; Kashiwagi Hirokazu; Shiraga Masamichi; Tadokoro Seiji; Kamae Tsuyoshi; Ujiie Hidetoshi; Honda Shigenori; Miyata Shigeki; Ijiri Yoshinobu; Yamamoto Junichiro; Maeda Norikazu; Funahashi Tohru; Kurata Yoshiyuki; Shimomura Iichiro; Tomiyama Yoshiaki; Kanakura Yuzuru
Adiponectin acts as an endogenous antithrombotic factor.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(1):224-30.
2006: Funahashi T; Nagasawa A; Hibuse T; Maeda N
Impact of glycerol gateway molecule in adipocytes.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(7):40-5.
2005: Liao Yulin; Takashima Seiji; Maeda Norikazu; Ouchi Noriyuki; Komamura Kazuo; Shimomura Iichiro; Hori Masatsugu; Matsuzawa Yuji; Funahashi Tohru; Kitakaze Masafumi
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism.
Cardiovascular research 2005;67(4):705-13.
2005: Ryo Miwa; Funahashi Tohru
[Adiponectin]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 8():595-9.
2005: Hibuse Toshiyuki; Maeda Norikazu; Funahashi Tohru; Yamamoto Kaori; Nagasawa Azumi; Mizunoya Wataru; Kishida Ken; Inoue Kazuo; Kuriyama Hiroshi; Nakamura Tadashi; Fushiki Tohru; Kihara Shinji; Shimomura Iichiro
Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):10993-8.
2005: Horio Takeshi; Suzuki Masaaki; Suzuki Kazutaka; Takamisawa Itaru; Hiuge Aki; Kamide Kei; Takiuchi Shin; Iwashima Yoshio; Kihara Shinji; Funahashi Tohru; Yoshimasa Yasunao; Kawano Yuhei
Pioglitazone improves left ventricular diastolic function in patients with essential hypertension.
American journal of hypertension 2005;18(7):949-57.
2005: Iwashima Yoshio; Katsuya Tomohiro; Ishikawa Kazuhiko; Kida Iwao; Ohishi Mitsuru; Horio Takeshi; Ouchi Noriyuki; Ohashi Koji; Kihara Shinji; Funahashi Tohru; Rakugi Hiromi; Ogihara Toshio
Association of hypoadiponectinemia with smoking habit in men.
Hypertension 2005;45(6):1094-100.
2005: Yamamoto K; Kiyohara T; Murayama Y; Kihara S; Okamoto Y; Funahashi T; Ito T; Nezu R; Tsutsui S; Miyagawa J-I; Tamura S; Matsuzawa Y; Shimomura I; Shinomura Y
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease.
Gut 2005;54(6):789-96.
2005: Ryo Miwa; Maeda Kazuhisa; Onda Tomohiro; Katashima Mitsuhiro; Okumiya Akiko; Nishida Makoto; Yamaguchi Tohru; Funahashi Tohru; Matsuzawa Yuji; Nakamura Tadashi; Shimomura Iichiro
A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance.
Diabetes care 2005;28(2):451-3.
2005: Fukuhara Atsunori; Matsuda Morihiro; Nishizawa Masako; Segawa Katsumori; Tanaka Masaki; Kishimoto Kae; Matsuki Yasushi; Murakami Mirei; Ichisaka Tomoko; Murakami Hiroko; Watanabe Eijiro; Takagi Toshiyuki; Akiyoshi Megumi; Ohtsubo Tsuguteru; Kihara Shinji; Yamashita Shizuya; Makishima Makoto; Funahashi Tohru; Yamanaka Shinya; Hiramatsu Ryuji; Matsuzawa Yuji; Shimomura Iichiro
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Science (New York, N.Y.) 2005;307(5708):426-30.
2004: Maeda Norikazu; Funahashi Tohru; Hibuse Toshiyuki; Nagasawa Azumi; Kishida Ken; Kuriyama Hiroshi; Nakamura Tadashi; Kihara Shinji; Shimomura Iichiro; Matsuzawa Yuji
Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(51):17801-6.
2004: Ryo Miwa; Nakamura Tadashi; Kihara Shinji; Kumada Masahiro; Shibazaki Satomi; Takahashi Mihoko; Nagai Masaki; Matsuzawa Yuji; Funahashi Tohru
Adiponectin as a biomarker of the metabolic syndrome.
Circulation journal : official journal of the Japanese Circulation Society 2004;68(11):975-81.
2004: Maeda Norikazu; Funahashi Tohru
[Adiponectin knockout mice]
Nippon rinsho. Japanese journal of clinical medicine 2004;62(6):1067-76.
2004: Iwashima Yoshio; Katsuya Tomohiro; Ishikawa Kazuhiko; Ouchi Noriyuki; Ohishi Mitsuru; Sugimoto Ken; Fu Yuxiao; Motone Masaharu; Yamamoto Kouichi; Matsuo Akiko; Ohashi Koji; Kihara Shinji; Funahashi Tohru; Rakugi Hiromi; Matsuzawa Yuji; Ogihara Toshio
Hypoadiponectinemia is an independent risk factor for hypertension.
Hypertension 2004;43(6):1318-23.
2004: Kumada Masahiro; Kihara Shinji; Ouchi Noriyuki; Kobayashi Hideki; Okamoto Yoshihisa; Ohashi Koji; Maeda Kazuhisa; Nagaretani Hiroyuki; Kishida Ken; Maeda Norikazu; Nagasawa Azumi; Funahashi Tohru; Matsuzawa Yuji
Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages.
Circulation 2004;109(17):2046-9.
2004: Ohashi Koji; Ouchi Noriyuki; Kihara Shinji; Funahashi Tohru; Nakamura Tadashi; Sumitsuji Satoru; Kawamoto Toshiharu; Matsumoto Satoru; Nagaretani Hiroyuki; Kumada Masahiro; Okamoto Yoshihisa; Nishizawa Hitoshi; Kishida Ken; Maeda Norikazu; Hiraoka Hisatoyo; Iwashima Yoshio; Ishikawa Kazuhiko; Ohishi Mitsuru; Katsuya Tomohiro; Rakugi Hiromi; Ogihara Toshio; Matsuzawa Yuji
Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease.
Journal of the American College of Cardiology 2004;43(7):1195-200.
2004: Kumada Masahiro; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji
[High sensitivity C-reactive protein analysis in th diagnosis of arteriosclerosis]
Nippon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 3():292-5.
2004: Kobayashi Hideki; Ouchi Noriyuki; Kihara Shinji; Walsh Kenneth; Kumada Masahiro; Abe Yuki; Funahashi Tohru; Matsuzawa Yuji
Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin.
Circulation research 2004;94(4):e27-31.
2004: Matsuzawa Yuji; Funahashi Tohru; Kihara Shinji; Shimomura Iichiro
Adiponectin and metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):29-33.
2003: Kamada Yoshihiro; Tamura Shinji; Kiso Shinichi; Matsumoto Hitoshi; Saji Yukiko; Yoshida Yuichi; Fukui Koji; Maeda Norikazu; Nishizawa Hitoshi; Nagaretani Hiroyuki; Okamoto Yoshihisa; Kihara Shinji; Miyagawa Jun-Ichiro; Shinomura Yasuhisa; Funahashi Tohru; Matsuzawa Yuji
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.
Gastroenterology 2003;125(6):1796-807.
2003: Ouchi Noriyuki; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Walsh Kenneth
Obesity, adiponectin and vascular inflammatory disease.
Current opinion in lipidology 2003;14(6):561-6.
2003: Miyoshi Yasuo; Funahashi Tohru; Kihara Shinji; Taguchi Tetsuya; Tamaki Yasuhiro; Matsuzawa Yuji; Noguchi Shinzaburo
Association of serum adiponectin levels with breast cancer risk.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5699-704.
2003: Nagasawa Azumi; Fukui Kensuke; Kojima Makiko; Kishida Ken; Maeda Norikazu; Nagaretani Hiroyuki; Hibuse Toshiyuki; Nishizawa Hitoshi; Kihara Shinji; Waki Masako; Takamatsu Kiyoharu; Funahashi Tohru; Matsuzawa Yuji
Divergent effects of soy protein diet on the expression of adipocytokines.
Biochemical and biophysical research communications 2003;311(4):909-14.
2003: Kishida Ken; Moriwaki Makoto; Miyagawa Jun-ichiro; Okita Kohei; Kondo Takashi; Itoh Kimiko; Umemura Satoshi; Kozawa Junji; Iwahashi Hiromi; Yoshizumi Tohru; Imagawa Akihisa; Yamagata Kazuya; Maruyama Takao; Toyoshima Hiroyuki; Kurokawa Eiji; Funahashi Tohru; Matsuzawa Yuji
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome.
Internal medicine (Tokyo, Japan) 2003;42(10):996-1005.
2003: Iwahashi H; Funahashi T; Kurokawa N; Sayama K; Fukuda E; Okita K; Imagawa A; Yamagata K; Shimomura I; Miyagawa J-I; Matsuzawa Y
Plasma adiponectin levels in women with anorexia nervosa.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(9):537-40.
2003: Ouchi Noriyuki; Ohishi Mitsuru; Kihara Shinji; Funahashi Tohru; Nakamura Tadashi; Nagaretani Hiroyuki; Kumada Masahiro; Ohashi Koji; Okamoto Yoshihisa; Nishizawa Hitoshi; Kishida Ken; Maeda Norikazu; Nagasawa Azumi; Kobayashi Hideki; Hiraoka Hisatoyo; Komai Norio; Kaibe Masaharu; Rakugi Hiromi; Ogihara Toshio; Matsuzawa Yuji
Association of hypoadiponectinemia with impaired vasoreactivity.
Hypertension 2003;42(3):231-4.
2003: Iwaki Masanori; Matsuda Morihiro; Maeda Norikazu; Funahashi Tohru; Matsuzawa Yuji; Makishima Makoto; Shimomura Iichiro
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors.
Diabetes 2003;52(7):1655-63.
2003: Kishida Ken; Nagaretani Hiroyuki; Kondo Hidehiko; Kobayashi Hideki; Tanaka Sachiyo; Maeda Norikazu; Nagasawa Azumi; Hibuse Toshiyuki; Ohashi Koji; Kumada Masahiro; Nishizawa Hitoshi; Okamoto Yoshihisa; Ouchi Noriyuki; Maeda Kazuhisa; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji
Disturbed secretion of mutant adiponectin associated with the metabolic syndrome.
Biochemical and biophysical research communications 2003;306(1):286-92.
2003: Ouchi Noriyuki; Kihara Shinji; Funahashi Tohru; Nakamura Tadashi; Nishida Makoto; Kumada Masahiro; Okamoto Yoshihisa; Ohashi Koji; Nagaretani Hiroyuki; Kishida Ken; Nishizawa Hitoshi; Maeda Norikazu; Kobayashi Hideki; Hiraoka Hisatoyo; Matsuzawa Yuji
Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue.
Circulation 2003;107(5):671-4.
2003: Kumada Masahiro; Kihara Shinji; Sumitsuji Satoru; Kawamoto Toshiharu; Matsumoto Satoru; Ouchi Noriyuki; Arita Yukio; Okamoto Yoshihisa; Shimomura Iichiro; Hiraoka Hisatoyo; Nakamura Tadashi; Funahashi Tohru; Matsuzawa Yuji;
Association of hypoadiponectinemia with coronary artery disease in men.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):85-9.
2003: Matsuzawa Yuji; Shimomura Iichiro; Kihara Shinji; Funahashi Tohru
Importance of adipocytokines in obesity-related diseases.
Hormone research 2003;60 Suppl 3():56-9.
2002: Nagasawa A; Fukui K; Funahashi T; Maeda N; Shimomura I; Kihara S; Waki M; Takamatsu K; Matsuzawa Y
Effects of soy protein diet on the expression of adipose genes and plasma adiponectin.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):635-9.
2002: Okamoto Yoshihisa; Kihara Shinji; Ouchi Noriyuki; Nishida Makoto; Arita Yukio; Kumada Masahiro; Ohashi Koji; Sakai Naohiko; Shimomura Iichiro; Kobayashi Hideki; Terasaka Naoki; Inaba Toshimori; Funahashi Tohru; Matsuzawa Yuji
Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice.
Circulation 2002;106(22):2767-70.
2002: Kuriyama Hiroshi; Shimomura Iichiro; Kishida Ken; Kondo Hidehiko; Furuyama Naoki; Nishizawa Hitoshi; Maeda Norikazu; Matsuda Morihiro; Nagaretani Hiroyuki; Kihara Shinji; Nakamura Tadashi; Tochino Yoshihiro; Funahashi Tohru; Matsuzawa Yuji
Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.
Diabetes 2002;51(10):2915-21.
2002: Matsuda Morihiro; Shimomura Iichiro; Sata Masataka; Arita Yukio; Nishida Makoto; Maeda Norikazu; Kumada Masahiro; Okamoto Yoshihisa; Nagaretani Hiroyuki; Nishizawa Hitoshi; Kishida Ken; Komuro Ryutaro; Ouchi Noriyuki; Kihara Shinji; Nagai Ryozo; Funahashi Tohru; Matsuzawa Yuji
Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis.
The Journal of biological chemistry 2002;277(40):37487-91.
2002: Nishizawa Hitoshi; Shimomura Iichiro; Kishida Ken; Maeda Norikazu; Kuriyama Hiroshi; Nagaretani Hiroyuki; Matsuda Morihiro; Kondo Hidehiko; Furuyama Naoki; Kihara Shinji; Nakamura Tadashi; Tochino Yoshihiro; Funahashi Tohru; Matsuzawa Yuji
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein.
Diabetes 2002;51(9):2734-41.
2002: Imagawa Akihisa; Funahashi Tohru; Nakamura Tadashi; Moriwaki Makoto; Tanaka Sachiyo; Nishizawa Hitoshi; Sayama Kouichi; Uno Sae; Iwahashi Hiromi; Yamagata Kazuya; Miyagawa Jun-Ichiro; Matsuzawa Yuji
Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes.
Diabetes care 2002;25(9):1665-6.
2002: Funahashi Tohru; Matsuzawa Yuji
[Adiponectin as a key molecule of the metabolic syndrome]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():583-92.
2002: Kondo Hidehiko; Shimomura Iichiro; Matsukawa Yuko; Kumada Masahiro; Takahashi Masahiko; Matsuda Morihiro; Ouchi Noriyuki; Kihara Shinji; Kawamoto Toshiharu; Sumitsuji Satoru; Funahashi Tohru; Matsuzawa Yuji
Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.
Diabetes 2002;51(7):2325-8.
2002: Maeda Norikazu; Shimomura Iichiro; Kishida Ken; Nishizawa Hitoshi; Matsuda Morihiro; Nagaretani Hiroyuki; Furuyama Naoki; Kondo Hidehiko; Takahashi Masahiko; Arita Yukio; Komuro Ryutaro; Ouchi Noriyuki; Kihara Shinji; Tochino Yoshihiro; Okutomi Keiichi; Horie Masato; Takeda Satoshi; Aoyama Toshifumi; Funahashi Tohru; Matsuzawa Yuji
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Nature medicine 2002;8(7):731-7.
2002: Arita Yukio; Kihara Shinji; Ouchi Noriyuki; Maeda Kazuhisa; Kuriyama Hiroshi; Okamoto Yoshihisa; Kumada Masahiro; Hotta Kikuko; Nishida Makoto; Takahashi Masahiko; Nakamura Tadashi; Shimomura Iichiro; Muraguchi Masahiro; Ohmoto Yasukazu; Funahashi Tohru; Matsuzawa Yuji
Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell.
Circulation 2002;105(24):2893-8.
2002: Kondo Hidehiko; Shimomura Iichiro; Kishida Ken; Kuriyama Hiroshi; Makino Yasunaka; Nishizawa Hitoshi; Matsuda Morihiro; Maeda Norikazu; Nagaretani Hiroyuki; Kihara Shinji; Kurachi Yoshihisa; Nakamura Tadashi; Funahashi Tohru; Matsuzawa Yuji
Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.
European journal of biochemistry / FEBS 2002;269(7):1814-26.
2002: Matsumoto Satoru; Kishida Ken; Shimomura Iichiro; Maeda Norikazu; Nagaretani Hiroyuki; Matsuda Morihiro; Nishizawa Hitoshi; Kihara Shinji; Funahashi Tohru; Matsuzawa Yuji; Yamada A; Yamashita S; Tamura S; Kawata S
Increased plasma HB-EGF associated with obesity and coronary artery disease.
Biochemical and biophysical research communications 2002;292(3):781-6.
2002: Matsuzawa Yuji; Funahashi Tohru; Nakamura Tadashi
Molecular mechanism of vascular disease in metabolic syndrome X.
Journal of diabetes and its complications 2002;16(1):17-8.
2002: Nishizawa Hitoshi; Yamagata Kazuya; Shimomura Iichiro; Takahashi Masahiko; Kuriyama Hiroshi; Kishida Ken; Hotta Kikuko; Nagaretani Hiroyuki; Maeda Norikazu; Matsuda Morihiro; Kihara Shinji; Nakamura Tadashi; Nishigori Hidekazu; Tomura Hideaki; Moore David D; Takeda Jun; Funahashi Tohru; Matsuzawa Yuji
Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation.
The Journal of biological chemistry 2002;277(2):1586-92.
2001: Nagaretani H; Nakamura T; Funahashi T; Kotani K; Miyanaga M; Tokunaga K; Takahashi M; Nishizawa H; Kishida K; Kuriyama H; Hotta K; Yamashita S; Matsuzawa Y
Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance.
Diabetes care 2001;24(12):2127-33.
2001: Nakamura T; Funahashi T; Yamashita S; Nishida M; Nishida Y; Takahashi M; Hotta K; Kuriyama H; Kihara S; Ohuchi N; Nishimura T; Kishino B I; Ishikawa K; Kawamoto T; Tokunaga K; Nakagawa C; Mineo I; Watanabe F; Tarui S; Matsuzawa Y
Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial.
Diabetes research and clinical practice 2001;54(3):181-90.
2001: Kishida K; Shimomura I; Nishizawa H; Maeda N; Kuriyama H; Kondo H; Matsuda M; Nagaretani H; Ouchi N; Hotta K; Kihara S; Kadowaki T; Funahashi T; Matsuzawa Y
Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma.
The Journal of biological chemistry 2001;276(51):48572-9.
2001: Maeda N; Takahashi M; Funahashi T; Kihara S; Nishizawa H; Kishida K; Nagaretani H; Matsuda M; Komuro R; Ouchi N; Kuriyama H; Hotta K; Nakamura T; Shimomura I; Matsuzawa Y
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Diabetes 2001;50(9):2094-9.
2001: Kishida K; Shimomura I; Kondo H; Kuriyama H; Makino Y; Nishizawa H; Maeda N; Matsuda M; Ouchi N; Kihara S; Kurachi Y; Funahashi T; Matsuzawa Y
Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.
The Journal of biological chemistry 2001;276(39):36251-60.
2001: Hotta K; Funahashi T; Matsukawa Y; Takahashi M; Nishizawa H; Kishida K; Matsuda M; Kuriyama H; Kihara S; Nakamura T; Tochino Y; Bodkin N L; Hansen B C; Matsuzawa Y
Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity.
The Journal of biological chemistry 2001;276(36):34089-97.
2001: Takahashi M; Nagaretani H; Funahashi T; Nishizawa H; Maeda N; Kishida K; Kuriyama H; Shimomura I; Maeda K; Hotta K; Ouchi N; Kihara S; Nakamura T; Yamashita S; Matsuzawa Y
The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease.
Obesity research 2001;9(7):388-93.
2001: Hotta K; Funahashi T; Bodkin N L; Ortmeyer H K; Arita Y; Hansen B C; Matsuzawa Y
Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.
Diabetes 2001;50(5):1126-33.
2001: Kobayashi H; Nakamura T; Miyaoka K; Nishida M; Funahashi T; Yamashita S; Matsuzawa Y
Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men.
Japanese circulation journal 2001;65(3):193-9.
2001: Kishida K; Kuriyama H; Funahashi T; Matsuzawa Y
[Molecular mechanism of energy regulation in adipose tissues]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():483-8.
2001: Ouchi N; Kihara S; Arita Y; Nishida M; Matsuyama A; Okamoto Y; Ishigami M; Kuriyama H; Kishida K; Nishizawa H; Hotta K; Muraguchi M; Ohmoto Y; Yamashita S; Funahashi T; Matsuzawa Y
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages.
Circulation 2001;103(8):1057-63.
2001: Nakamura T; Tsubono Y; Kameda-Takemura K; Funahashi T; Yamashita S; Hisamichi S; Kita T; Yamamura T; Matsuzawa Y;
Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees: a case-control study.
Japanese circulation journal 2001;65(1):11-7.
2000: Ouchi N; Kihara S; Arita Y; Okamoto Y; Maeda K; Kuriyama H; Hotta K; Nishida M; Takahashi M; Muraguchi M; Ohmoto Y; Nakamura T; Yamashita S; Funahashi T; Matsuzawa Y
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway.
Circulation 2000;102(11):1296-301.
2000: Yokota T; Oritani K; Takahashi I; Ishikawa J; Matsuyama A; Ouchi N; Kihara S; Funahashi T; Tenner A J; Tomiyama Y; Matsuzawa Y
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.
Blood 2000;96(5):1723-32.
2000: Takahashi M; Arita Y; Yamagata K; Matsukawa Y; Okutomi K; Horie M; Shimomura I; Hotta K; Kuriyama H; Kihara S; Nakamura T; Yamashita S; Funahashi T; Matsuzawa Y
Genomic structure and mutations in adipose-specific gene, adiponectin.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(7):861-8.
2000: Kishida K; Kuriyama H; Funahashi T; Shimomura I; Kihara S; Ouchi N; Nishida M; Nishizawa H; Matsuda M; Takahashi M; Hotta K; Nakamura T; Yamashita S; Tochino Y; Matsuzawa Y
Aquaporin adipose, a putative glycerol channel in adipocytes.
The Journal of biological chemistry 2000;275(27):20896-902.
2000: Hotta K; Funahashi T; Arita Y; Takahashi M; Matsuda M; Okamoto Y; Iwahashi H; Kuriyama H; Ouchi N; Maeda K; Nishida M; Kihara S; Sakai N; Nakajima T; Hasegawa K; Muraguchi M; Ohmoto Y; Nakamura T; Yamashita S; Hanafusa T; Matsuzawa Y
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(6):1595-9.
2000: Komuro R; Yamashita S; Sumitsuji S; Hirano K; Maruyama T; Nishida M; Matsuura F; Matsuyama A; Sugimoto T; Ouchi N; Sakai N; Nakamura T; Funahashi T; Matsuzawa Y
Tangier disease with continuous massive and longitudinal diffuse calcification in the coronary arteries : demonstration by the sagittal images of intravascular ultrasonography.
Circulation 2000;101(20):2446-8.
2000: Okamoto Y; Arita Y; Nishida M; Muraguchi M; Ouchi N; Takahashi M; Igura T; Inui Y; Kihara S; Nakamura T; Yamashita S; Miyagawa J; Funahashi T; Matsuzawa Y
An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(2):47-50.
2000: Hotta K; Matsukawa Y; Nishida M; Kotani K; Takahashi M; Kuriyama H; Nakamura T; Wada K; Yamashita S; Funahashi T; Matsuzawa Y
Mutation in bombesin receptor subtype-3 gene is not a major cause of obesity in the Japanese.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(1):33-4.
1999: Ouchi N; Kihara S; Arita Y; Maeda K; Kuriyama H; Okamoto Y; Hotta K; Nishida M; Takahashi M; Nakamura T; Yamashita S; Funahashi T; Matsuzawa Y
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.
Circulation 1999;100(25):2473-6.
1999: Matsuzawa Y; Funahashi T; Nakamura T
Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances.
Annals of the New York Academy of Sciences 1999;892():146-54.
1999: Arita Y; Kihara S; Ouchi N; Takahashi M; Maeda K; Miyagawa J; Hotta K; Shimomura I; Nakamura T; Miyaoka K; Kuriyama H; Nishida M; Yamashita S; Okubo K; Matsubara K; Muraguchi M; Ohmoto Y; Funahashi T; Matsuzawa Y
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Biochemical and biophysical research communications 1999;257(1):79-83.
1999: Funahashi T; Nakamura T; Shimomura I; Maeda K; Kuriyama H; Takahashi M; Arita Y; Kihara S; Matsuzawa Y
Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity.
Internal medicine (Tokyo, Japan) 1999;38(2):202-6.
1999: Matsuura F; Yamashita S; Hirano K; Ishigami M; Hiraoka H; Tamura R; Nakagawa T; Nishida M; Sakai N; Nakamura T; Nozaki S; Funahashi T; Matsumoto C; Higashiyama M; Yoshikawa K; Matsuzawa Y
Activation of monocytes in vivo causes intracellular accumulation of lipoprotein-derived lipids and marked hypocholesterolemia--a possible pathogenesis of necrobiotic xanthogranuloma.
Atherosclerosis 1999;142(2):355-65.
1998: Nakagawa T; Nozaki S; Nishida M; Yakub J M; Tomiyama Y; Nakata A; Matsumoto K; Funahashi T; Kameda-Takemura K; Kurata Y; Yamashita S; Matsuzawa Y
Oxidized LDL increases and interferon-gamma decreases expression of CD36 in human monocyte-derived macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(8):1350-7.
1998: Matsuura F; Yamashita S; Nakamura T; Nishida M; Nozaki S; Funahashi T; Matsuzawa Y
Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity.
Metabolism: clinical and experimental 1998;47(8):929-33.
1998: Shinohara E; Kihara S; Ouchi N; Funahashi T; Nakamura T; Yamashita S; Kameda-Takemura K; Matsuzawa Y
Troglitazone suppresses intimal formation following balloon injury in insulin-resistant Zucker fatty rats.
Atherosclerosis 1998;136(2):275-9.
1998: Kuriyama H; Yamashita S; Shimomura I; Funahashi T; Ishigami M; Aragane K; Miyaoka K; Nakamura T; Takemura K; Man Z; Toide K; Nakayama N; Fukuda Y; Lin M C; Wetterau J R; Matsuzawa Y
Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation.
Hepatology (Baltimore, Md.) 1998;27(2):557-62.
1998: Kihara S; Ouchi N; Funahashi T; Shinohara E; Tamura R; Yamashita S; Matsuzawa Y
Troglitazone enhances glucose uptake and inhibits mitogen-activated protein kinase in human aortic smooth muscle cells.
Atherosclerosis 1998;136(1):163-8.
1997: Ouchi N; Kihara S; Yamashita S; Higashiyama S; Nakagawa T; Shimomura I; Funahashi T; Kameda-Takemura K; Kawata S; Taniguchi N; Matsuzawa Y
Role of membrane-anchored heparin-binding epidermal growth factor-like growth factor and CD9 on macrophages.
The Biochemical journal 1997;328 ( Pt 3)():923-8.
1997: Kotani K; Nishida M; Yamashita S; Funahashi T; Fujioka S; Tokunaga K; Ishikawa K; Tarui S; Matsuzawa Y
Two decades of annual medical examinations in Japanese obese children: do obese children grow into obese adults?
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(10):912-21.
1997: Yanagi K; Yamashita S; Kihara S; Nakamura T; Nozaki S; Nagai Y; Funahashi T; Kameda-Takemura K; Ueyama Y; Jiao S; Kubo M; Tokunaga K; Matsuzawa Y
Characteristics of coronary artery disease and lipoprotein abnormalities in patients with heterozygous familial hypercholesterolemia associated with diabetes mellitus or impaired glucose tolerance.
Atherosclerosis 1997;132(1):43-51.
1997: Nakamura T; Kobayashi H; Yanagi K; Nakagawa T; Nishida M; Kihara S; Hiraoka H; Nozaki S; Funahashi T; Yamashita S; Kameda-Takemura K; Matsuzawa Y
Importance of intra-abdominal visceral fat accumulation to coronary atherosclerosis in heterozygous familial hypercholesterolaemia.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(7):580-6.
1997: Yanagi K; Yamashita S; Hiraoka H; Ishigami M; Kihara S; Hirano K; Sakai N; Nozaki S; Funahashi T; Kameda-Takemura K; Kubo M; Tokunaga K; Matsuzawa Y
Increased serum remnant lipoproteins in patients with apolipoprotein E7 (apo E Suita).
Atherosclerosis 1997;131(1):49-58.
1996: Takahashi M; Funahashi T; Shimomura I; Miyaoka K; Matsuzawa Y
Plasma leptin levels and body fat distribution.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(12):751-2.
1996: Arai T; Yamashita S; Sakai N; Hirano K; Okada S; Ishigami M; Maruyama T; Yamane M; Kobayashi H; Nozaki S; Funahashi T; Kameda-Takemura K; Nakajima N; Matsuzawa Y
A novel nonsense mutation (G181X) in the human cholesteryl ester transfer protein gene in Japanese hyperalphalipoproteinemic subjects.
Journal of lipid research 1996;37(10):2145-54.
1996: Shimomura I; Funahashi T; Takahashi M; Maeda K; Kotani K; Nakamura T; Yamashita S; Miura M; Fukuda Y; Takemura K; Tokunaga K; Matsuzawa Y
Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity.
Nature medicine 1996;2(7):800-3.
1996: Shimomura I; Takahashi M; Tokunaga K; Keno Y; Nakamura T; Yamashita S; Takemura K; Yamamoto T; Funahashi T; Matsuzawa Y
Rapid enhancement of acyl-CoA synthetase, LPL, and GLUT-4 mRNAs in adipose tissue of VMH rats.
The American journal of physiology 1996;270(6 Pt 1):E995-1002.
1996: Maeda K; Okubo K; Shimomura I; Funahashi T; Matsuzawa Y; Matsubara K
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).
Biochemical and biophysical research communications 1996;221(2):286-9.
1996: Funahashi T; Yamashita S; Maruyama T; Ueyama Y; Menju M; Nagai Y; Takemura K; Miyake Y; Tajima S; Matsuzawa Y
A compound heterozygote for familial hypercholesterolaemia with a homozygous mother.
Journal of internal medicine 1996;239(2):187-90.
1995: Funahashi T; Shimomura I; Hiraoka H; Arai T; Takahashi M; Nakamura T; Nozaki S; Yamashita S; Takemura K; Tokunaga K
Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats.
Biochemical and biophysical research communications 1995;211(2):469-75.
1995: Sakai N; Yamashita S; Hirano K; Ishigami M; Arai T; Kobayashi K; Funahashi T; Matsuzawa Y
Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency.
European journal of clinical investigation 1995;25(5):332-9.
1995: Nakagawa T; Ueyama Y; Nozaki S; Yamashita S; Menju M; Funahashi T; Kameda-Takemura K; Kubo M; Tokunaga K; Tanaka T
Marked hypocholesterolemia in a case with adrenal adenoma--enhanced catabolism of low density lipoprotein (LDL) via the LDL receptors of tumor cells.
The Journal of clinical endocrinology and metabolism 1995;80(1):92-6.
1993: Sakai N; Yamashita S; Ueyama Y; Kawamoto T; Nakamura T; Funahashi T; Kameda-Takemura K; Kawata S; Kubo M; Tokunaga K
Extralysosomal degradation of high-density lipoproteins in a human hepatoma cell line, Mahlavu.
Biochimica et biophysica acta 1993;1169(2):169-75.
1993: Shimomura I; Tokunaga K; Kotani K; Keno Y; Yanase-Fujiwara M; Kanosue K; Jiao S; Funahashi T; Kobatake T; Yamamoto T
Marked reduction of acyl-CoA synthetase activity and mRNA in intra-abdominal visceral fat by physical exercise.
The American journal of physiology 1993;265(1 Pt 1):E44-50.
1993: Hirano K; Yamashita S; Funahashi T; Sakai N; Menju M; Ishigami M; Hiraoka H; Kameda-Takemura K; Tokunaga K; Hoshino T
Frequency of intron 14 splicing defect of cholesteryl ester transfer protein gene in the Japanese general population--relation between the mutation and hyperalphalipoproteinemia.
Atherosclerosis 1993;100(1):85-90.
1992: Hirano K; Matsuzawa Y; Sakai N; Hiraoka H; Nozaki S; Funahashi T; Yamashita S; Kubo M; Tarui S
Polydisperse low-density lipoproteins in hyperalphalipoproteinemic chronic alcohol drinkers in association with marked reduction of cholesteryl ester transfer protein activity.
Metabolism: clinical and experimental 1992;41(12):1313-8.
1992: Hirano K; Yamashita S; Sakai N; Hiraoka H; Ueyama Y; Funahashi T; Matsuzawa Y
Low-density lipoproteins in hyperalphalipoproteinemic heavy alcohol drinkers have reduced affinity for the low-density lipoprotein receptor.
Clinical biochemistry 1992;25(5):357-62.
1992: Nozaki S; Shimomura I; Funahashi T; Menju M; Kubo M; Matsuzawa Y
Stimulation of the activity and mRNA level of hepatic triacylglycerol lipase by triiodothyronine in HepG2 cells.
Biochimica et biophysica acta 1992;1127(3):298-302.
1992: Shimomura I; Tokunaga K; Jiao S; Funahashi T; Keno Y; Kobatake T; Kotani K; Suzuki H; Yamamoto T; Tarui S
Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa).
Biochimica et biophysica acta 1992;1124(2):112-8.
1992: Nakamura T; Ueyama Y; Funahashi T; Yamashita S; Takemura K K; Kubo M; Yamada K; Matsuzawa Y
Non-macrophage-related accumulation of cholesterol during probucol treatment in familial hypercholesterolemia: report of two cases.
Atherosclerosis 1992;92(2-3):193-202.
1990: Ueyama Y; Matsuzawa Y; Yamashita S; Funahashi T; Sakai N; Nakamura T; Kubo M; Tarui S
Hypocholesterolaemic factor from gallbladder cancer cells.
Lancet 1990;336(8717):707-9.
1989: Kihara S; Matsuzawa Y; Kubo M; Nozaki S; Funahashi T; Yamashita S; Sho N; Tarui S
Autoimmune hyperchylomicronemia.
The New England journal of medicine 1989;320(19):1255-9.
1988: Nakajima T; Nakamura T; Funahashi T; Kanai H; Kurata Y; Matsuzawa Y; Tarui S
A novel system of LDL apheresis combining a centrifugal plasma separator with a specific LDL adsorption column.
Atherosclerosis 1988;73(2-3):143-8.
1988: Matsuzawa Y; Yamashita S; Funahashi T; Yamamoto A; Tarui S
Selective reduction of cholesterol in HDL2 fraction by probucol in familial hypercholesterolemia and hyperHDL2 cholesterolemia with abnormal cholesteryl ester transfer.
The American journal of cardiology 1988;62(3):66B-72B.
1988: Nakamura T; Matsuzawa Y; Okano M; Kitano Y; Funahashi T; Yamashita S; Tarui S
Characterization of low-density lipoproteins from patients with recessive X-linked ichthyosis.
Atherosclerosis 1988;70(1-2):43-52.
1987: Yamashita S; Kawamoto T; Ueyama Y; Funahashi T; Hara H; Hirobe K; Matsuzawa Y; Yamamoto A; Tarui S
Relationship between LDL receptor activity and development of coronary heart disease in Japanese cases with heterozygous familial hypercholesterolemia.
Artery 1987;15(1):24-43.

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