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Wai-Ping Fung-Leung

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Jeffery M Cowden; Paul J Dunford; Wai-Ping Fung-Leung; Jing-Feng Huang; Sunhwa Kim; Jing Ying Ma; Jason P Riley; Fuqu Yu; Mai Zhang; Mamatha Challapalli; Robin Thurmond
Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo.
Wai-Ping Fung-Leung
Phosphoinositide 3-kinase gamma in T cell biology and disease therapy.
Wai-Ping Fung-Leung
Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function.

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2013: Jeffery M Cowden; Paul J Dunford; Wai-Ping Fung-Leung; Jing-Feng Huang; Sunhwa Kim; Jing Ying Ma; Jason P Riley; Fuqu Yu; Mai Zhang; Mamatha Challapalli; Robin Thurmond
Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2013;62(6):599-607.
2013: Wai-Ping Fung-Leung
Phosphoinositide 3-kinase gamma in T cell biology and disease therapy.
Annals of the New York Academy of Sciences 2013;1280():40-3.
2011: Wai-Ping Fung-Leung
Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function.
Cellular signalling 2011;23(4):603-8.
2010: Jennifer D Venable; Michael K Ameriks; Jonathan M Blevitt; Robin L Thurmond; Wai-Ping Fung-Leung
Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease.
Recent patents on inflammation & allergy drug discovery 2010;4(1):1-15.
2008: Sridevi Gottipati; Navin L Rao; Wai-Ping Fung-Leung
IRAK1: a critical signaling mediator of innate immunity.
Cellular signalling 2008;20(2):269-76.
2006: Miguel A Sanjuan; Navin Rao; Kuei-Tai A Lai; Yin Gu; Siquan Sun; Anja Fuchs; Wai-Ping Fung-Leung; Marco COLONna; Lars Karlsson
CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.
The Journal of cell biology 2006;172(7):1057-68.
2005: Navin Rao; Steven Nguyen; Karen Ngo; Wai-Ping Fung-Leung
A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.
Molecular and cellular biology 2005;25(15):6521-32.
2004: Wai-Ping Fung-Leung; Robin Thurmond; Ping Ling; Lars Karlsson
Histamine H4 receptor antagonists: the new antihistamines?
Current opinion in investigational drugs (London, England : 2000) 2004;5(11):1174-83.
2004: Ping Ling; Karen Ngo; Steven Nguyen; Robin Thurmond; James P Edwards; Lars Karlsson; Wai-Ping Fung-Leung
Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.
British journal of pharmacology 2004;142(1):161-71.
2004: Robin Thurmond; Pragnya J Desai; Paul J Dunford; Wai-Ping Fung-Leung; Claudia L Hofstra; Wendy Jiang; Steven Nguyen; Jason P Riley; Siquan Sun; Kacy N Williams; James P Edwards; Lars Karlsson
A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties.
The Journal of pharmacology and experimental therapeutics 2004;309(1):404-13.
2003: Claudia L Hofstra; Pragnya J Desai; Robin Thurmond; Wai-Ping Fung-Leung
Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1212-21.
2003: Motohiro Koyama; Nahid Seyedi; Wai-Ping Fung-Leung; Timothy W Lovenberg; Roberto Levi
Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors.
Molecular pharmacology 2003;63(2):378-82.
2002: Susanne I Mayr; Riaz I Zuberi; Min Zhang; Jean de Sousa-Hitzler; Karen Ngo; Yasuko Kuwabara; Lan Yu; Wai-Ping Fung-Leung; Fu-Tong Liu
IgE-dependent mast cell activation potentiates airway responses in murine asthma models.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):2061-8.
2002: Hiroshi Toyota; Christine Dugovic; Muriel Koehl; Aaron D Laposky; China Weber; Karen Ngo; Ying Wu; Doo H Lee; Kazuhiko Yanai; Eiko Sakurai; Takehiko Watanabe; Changlu Liu; Jingcai Chen; Ann J Barbier; Fred W Turek; Wai-Ping Fung-Leung; Timothy W Lovenberg
Behavioral characterization of mice lacking histamine H(3) receptors.
Molecular pharmacology 2002;62(2):389-97.
2002: Miranda van Eck; I Sophie T Bos; Wolfgang E Kaminski; Evelyn Orsó; Gregor Rothe; Jaap Twisk; Alfred Böttcher; Edwin S Van Amersfoort; Trudy A Christiansen-Weber; Wai-Ping Fung-Leung; Theo Van berkel; Gerd Schmitz
Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6298-303.
2000: Trudy A Christiansen-Weber; J R Voland; Ying Wu; Karen Ngo; Barbara Roland; Steven Nguyen; PA Peterson; Wai-Ping Fung-Leung
Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency.
The American journal of pathology 2000;157(3):1017-29.
2000: P Shier; Claudia L Hofstra; X J Ma; Ying Wu; Karen Ngo; Wai-Ping Fung-Leung
Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells.
Immunogenetics 2000;51(10):771-8.
2000: Daniel K Hsu; Ri-Yao Yang; Z Pan; Lan Yu; D R Salomon; Wai-Ping Fung-Leung; Fu-Tong Liu
Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.
The American journal of pathology 2000;156(3):1073-83.
1999: T Preckel; Wai-Ping Fung-Leung; Z Cai; Antonella Vitiello; L Salter-Cid; Ola Winqvist; Tom Wolfe; M Von Herrath; Ana Angulo; Peter Ghazal; J D Lee; AM Fourie; Ying Wu; J Pang; Karen Ngo; PA Peterson; Klaus J Frueh; yang robin
Impaired immunoproteasome assembly and immune responses in PA28-/- mice.
Science (New York, N.Y.) 1999;286(5447):2162-5.
1999: Christopher Alfonso; M Liljedahl; Ola Winqvist; Charles D Surh; PA Peterson; Wai-Ping Fung-Leung; Lars Karlsson
The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation.
Immunological reviews 1999;172():255-66.
1999: P Shier; Karen Ngo; Wai-Ping Fung-Leung
Defective CD8+ T cell activation and cytolytic function in the absence of LFA-1 cannot be restored by increased TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(9):4826-32.
1999: P Kanakaraj; Karen Ngo; Ying Wu; Ana Angulo; Peter Ghazal; CA Harris; John Siekierka; PA Peterson; Wai-Ping Fung-Leung
Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice.
The Journal of experimental medicine 1999;189(7):1129-38.
1999: Bruce Damiano; Wai-Man Cheung; Rosemary J Santulli; Wai-Ping Fung-Leung; Karen Ngo; Richard D Ye; Andrew L Darrow; Claudia K Derian; Lawrence de Garavilla; Patricia Andrade-Gordon
Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1.
The Journal of pharmacology and experimental therapeutics 1999;288(2):671-8.
1998: P Kanakaraj; PH Schafer; Druie Cavender; Ying Wu; Karen Ngo; P F Grealish; S A Wadsworth; PA Peterson; John Siekierka; CA Harris; Wai-Ping Fung-Leung
Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.
The Journal of experimental medicine 1998;187(12):2073-9.
1998: M Liljedahl; Ola Winqvist; Charles D Surh; P Wong; Karen Ngo; Luc Teyton; PA Peterson; AB Brunmark; A Y Rudensky; Wai-Ping Fung-Leung; Lars Karlsson
Altered antigen presentation in mice lacking H2-O.
Immunity 1998;8(2):233-43.
1997: Charles D Surh; DS Lee; Wai-Ping Fung-Leung; Lars Karlsson; Jonathan Sprent
Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.
Immunity 1997;7(2):209-19.
1996: P Shier; G Otulakowski; Karen Ngo; J Panakos; E Chourmouzis; L Christjansen; C Y Lau; Wai-Ping Fung-Leung
Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5375-86.
1996: Andrew L Darrow; Wai-Ping Fung-Leung; Richard D Ye; Rosemary J Santulli; Wai-Man Cheung; Claudia K Derian; C L Burns; Bruce Damiano; L Zhou; C M Keenan; P A Peterson; Patricia Andrade-Gordon
Biological consequences of thrombin receptor deficiency in mice.
Thrombosis and haemostasis 1996;76(6):860-6.
1996: M Liljedahl; T Kuwana; Wai-Ping Fung-Leung; MR Jackson; PA Peterson; Lars Karlsson
HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.
The EMBO journal 1996;15(18):4817-24.
1996: A H Dalloul; E Chmouzis; Karen Ngo; Wai-Ping Fung-Leung
Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4114-9.
1996: Wai-Ping Fung-Leung; Charles D Surh; M Liljedahl; J Pang; D Leturcq; PA Peterson; SR Webb; Lars Karlsson
Antigen presentation and T cell development in H2-M-deficient mice.
Science (New York, N.Y.) 1996;271(5253):1278-81.
1996: A H Dalloul; Karen Ngo; Wai-Ping Fung-Leung
CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice.
European journal of immunology 1996;26(1):213-8.
1996: L Zhou; B L Pope; E Chourmouzis; Wai-Ping Fung-Leung; C Y Lau
Tepoxalin blocks neutrophil migration into cutaneous inflammatory sites by inhibiting Mac-1 and E-selectin expression.
European journal of immunology 1996;26(1):120-9.
1996: Wai-Ping Fung-Leung; J De Sousa-Hitzler; A Ishaque; L Zhou; J Pang; Karen Ngo; J A Panakos; E Chourmouzis; Fu-Tong Liu; C Y Lau
Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions.
The Journal of experimental medicine 1996;183(1):49-56.
1995: L Zhang; Wai-Ping Fung-Leung; Richard G Miller
Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3464-71.
1995: D R Koh; A Ho; Amin Rahemtulla; Wai-Ping Fung-Leung; H Griesser; Tak W Mak
Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.
European journal of immunology 1995;25(9):2558-62.
1995: Wai-Ping Fung-Leung; B L Pope; E Chourmouzis; J A Panakos; C Y Lau
Tepoxalin, a novel immunomodulatory compound, synergizes with CsA in suppression of graft-versus-host reaction and allogeneic skin graft rejection.
Transplantation 1995;60(4):362-8.
1995: Wai-Ping Fung-Leung; Kenji Kishihara; D Gray; H S Teh; C Y Lau; Tak W Mak
Intestinal T cells in CD8 alpha knockout mice and T cell receptor transgenic mice.
Advances in experimental medicine and biology 1995;371A():121-4.
1994: Wai-Ping Fung-Leung; TM Kündig; Karen Ngo; J Panakos; J De Sousa-Hitzler; E Wang; Pamela S Ohashi; Tak W Mak; C Y Lau
Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.
The Journal of experimental medicine 1994;180(3):959-67.
1994: T Lin; Goro Matsuzaki; H Kenai; Kenji Kishihara; S Nabeshima; Wai-Ping Fung-Leung; T W Mak; Kikuo Nomoto
Characteristics of fetal thymus-derived T cell receptor gamma delta intestinal intraepithelial lymphocytes.
European journal of immunology 1994;24(8):1792-8.
1994: G Otulakowski; L Zhou; Wai-Ping Fung-Leung; G J Gendimenico; S E Samuel; C Y Lau
Use of a human skin-grafted nude mouse model for the evaluation of topical retinoic acid treatment.
The Journal of investigative dermatology 1994;102(4):515-8.
1993: J Pang; G R Taylor; D G Munroe; A Ishaque; Wai-Ping Fung-Leung; C Y Lau; Fu-Tong Liu; L Zhou
Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6166-74.
1993: Wai-Ping Fung-Leung; M C Louie; A Limmer; Pamela S Ohashi; Karen Ngo; L Chen; K Kawai; Elizabeth Lacy; D Y Loh; Tak W Mak
The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes.
European journal of immunology 1993;23(11):2834-40.
1993: I T Chan; A Limmer; M C Louie; E D Bullock; Wai-Ping Fung-Leung; Tak W Mak; D Y Loh
Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association.
Science (New York, N.Y.) 1993;261(5128):1581-4.
1993: M W Schilham; Wai-Ping Fung-Leung; Amin Rahemtulla; T Kuendig; L Zhang; J Potter; Richard G Miller; H Hengartner; Tak W Mak
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.
European journal of immunology 1993;23(6):1299-304.
1993: Wai-Ping Fung-Leung; V A Wallace; D Gray; W C Sha; Hanspeter Pircher; H S Teh; D Y Loh; Tak W Mak
CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny.
European journal of immunology 1993;23(1):212-6.
1992: V A Wallace; Wai-Ping Fung-Leung; E Timms; D Gray; Kenji Kishihara; D Y Loh; Josef M Penninger; Tak W Mak
CD45RA and CD45RBhigh expression induced by thymic selection events.
The Journal of experimental medicine 1992;176(6):1657-63.
1992: L I Zhang; D R Martin; Wai-Ping Fung-Leung; H S Teh; Richard G Miller
Peripheral deletion of mature CD8+ antigen-specific T cells after in vivo exposure to male antigen.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):3740-5.
1992: D R Koh; Wai-Ping Fung-Leung; A Ho; D Gray; H Acha-Orbea; Tak W Mak
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.
Science (New York, N.Y.) 1992;256(5060):1210-3.
1992: Wai-Ping Fung-Leung; T W Mak
Embryonic stem cells and homologous recombination.
Current opinion in immunology 1992;4(2):189-94.
1992: Tak W Mak; Amin Rahemtulla; M Schilham; D R Koh; Wai-Ping Fung-Leung
Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
Journal of autoimmunity 1992;5 Suppl A():55-9.
1992: Tak W Mak; Amin Rahemtulla; M Schilham; D R Koh; Wai-Ping Fung-Leung
Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting.
Advances in experimental medicine and biology 1992;323():73-7.
1991: Wai-Ping Fung-Leung; TM Kündig; Rolf M Zinkernagel; Tak W Mak
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.
The Journal of experimental medicine 1991;174(6):1425-9.
1991: Amin Rahemtulla; Wai-Ping Fung-Leung; M W Schilham; TM Kündig; S R Sambhara; A Narendran; A Arabian; Andrew Wakeham; Christopher J Paige; Rolf M Zinkernagel
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
Nature 1991;353(6340):180-4.
1991: Wai-Ping Fung-Leung; M W Schilham; Amin Rahemtulla; TM Kündig; M Vollenweider; J Potter; W van Ewijk; Tak W Mak
CD8 is needed for development of cytotoxic T cells but not helper T cells.
Cell 1991;65(3):443-9.